{"id":3278,"date":"2020-11-28T21:19:45","date_gmt":"2020-11-28T13:19:45","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2020\/11\/28\/pd-1-pd-l1%e9%98%bb%e6%96%ad%e5%89%82%e6%b2%bb%e7%96%97%e8%82%bf%e7%98%a4%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e4%b8%8e%e9%9d%a2%e4%b8%b4%e7%9a%84%e6%8c%91%e6%88%98\/"},"modified":"2020-11-28T21:19:45","modified_gmt":"2020-11-28T13:19:45","slug":"pd-1-pd-l1%e9%98%bb%e6%96%ad%e5%89%82%e6%b2%bb%e7%96%97%e8%82%bf%e7%98%a4%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e4%b8%8e%e9%9d%a2%e4%b8%b4%e7%9a%84%e6%8c%91%e6%88%98","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2020\/11\/28\/pd-1-pd-l1%e9%98%bb%e6%96%ad%e5%89%82%e6%b2%bb%e7%96%97%e8%82%bf%e7%98%a4%e7%9a%84%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e4%b8%8e%e9%9d%a2%e4%b8%b4%e7%9a%84%e6%8c%91%e6%88%98\/","title":{"rendered":"PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218"},"content":{"rendered":"
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    \u4f17\u6240\u5468\u77e5\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u80fd\u591f\u589e\u5f3a\u6548\u5e94T\u7ec6\u80de\u529f\u80fd\uff0c\u4f7f\u8bb8\u591a\u60a3\u8005\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\u3002\u5728\u8fc7\u53bb\u7684\u5341\u51e0\u5e74\u4e2d\uff0cICI \u5f7b\u5e95\u6539\u53d8\u4e86\u665a\u671f\u6076\u6027\u80bf\u7624\u7684\u4e34\u5e8a\u6cbb\u7597\u65b9\u5f0f\uff0c\u4e5f\u6781\u5927\u5730\u626d\u8f6c\u4e86\u4f9d\u8d56\u653e\u7597\uff0c\u5316\u7597\u548c\u624b\u672f\u7b49\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\u7684\u73b0\u72b6\u3002\u7a0b\u5e8f\u6027\u6b7b\u4ea11\uff08PD-1\uff09\u5728\u6d3b\u5316\u7684T\u7ec6\u80de\u4e0a\u8868\u8fbe\u5e76\u8d1f\u8d23\u8c03\u63a7T\u7ec6\u80de\u53cd\u5e94\uff0c\u662f\u80bf\u7624\u8bf1\u5bfc\u514d\u75ab\u6291\u5236\u4e2d\u5173\u952e\u7684\u68c0\u67e5\u70b9\u5206\u5b50\u3002\u73b0\u5df2\u8bc1\u660e\u53ef\u901a\u8fc7\u963b\u65adPD-1\u53ca\u5176\u914d\u4f53PD-L1\u6216PD-L2\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u589e\u5f3aT\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u9776\u5411PD-1 \/ PD-L1\u68c0\u67e5\u70b9\u7684\u6297\u4f53\u53ef\u901a\u8fc7\u6253\u7834\u514d\u75ab\u6291\u5236\u72b6\u6001\u6765\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u4ece\u800c\u4f7f\u80bf\u7624\u5904\u4e8e\u53d7\u63a7\u72b6\u6001\u3002\u8fd9\u79cd\u7b56\u7565\u5df2\u7ecf\u6210\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\uff0c\u5e76\u4e14\u5728\u6cbb\u7597\u6076\u6027\u80bf\u7624\u4e2d\u8d77\u7740\u8d8a\u6765\u8d8a\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n

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\u56fe1. PD-1 \/ PD-L1\u6291\u5236\u5242\u514d\u75ab\u7597\u6cd5\u793a\u610f\u56fe<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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    \u5c3d\u7ba1\u8bb8\u591a\u6076\u6027\u80bf\u7624\u60a3\u8005\u53d7\u76ca\u4e8e\u4f7f\u7528PD-1 \/ PD-L1\u6291\u5236\u5242\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u4f46\u76ee\u524d\u4ecd\u6ca1\u6709\u6709\u6548\u7684\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u6765\u6307\u5bfc\u4e34\u5e8a\u7cbe\u51c6\u7528\u836f\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u3002\u4e0e\u514d\u75ab\u7597\u6cd5\u76f8\u5173\u7684\u9884\u6d4b\u6307\u6807\u7684\u7814\u7a76\u548c\u9274\u5b9a\u53ef\u4ee5\u4fc3\u8fdb\u80bf\u7624\u7684\u7cbe\u51c6\u6cbb\u7597\u5e76\u5e2e\u52a9\u514b\u670d\u8010\u836f\u6027\u6216\u4e0d\u826f\u53cd\u5e94\u3002\u8fd9\u7bc7\u7efc\u8ff0\u7740\u91cd\u4e8e\u4ecb\u7ecdPD-1 \/ PD-L1\u6291\u5236\u5242\u7684\u529f\u6548\u6539\u5584\u4ee5\u53ca\u5bf9\u60a3\u8005\u7684\u6709\u6548\u7b5b\u67e5\u53ef\u4ee5\u6700\u5927\u7a0b\u5ea6\u5730\u51cf\u5c11\u526f\u4f5c\u7528\u65b9\u9762\u7684\u6700\u65b0\u8fdb\u5c55\uff1b\u603b\u7ed3\u4e86\u9884\u6d4bPD-1 \/ PD-L1\u6cbb\u7597\u7684\u7597\u6548\uff0c\u5e38\u89c1\u526f\u4f5c\u7528\u548c\u539f\u56e0\u4ee5\u53ca\u8054\u5408\u6cbb\u7597\u7b56\u7565\u7684\u4e00\u4e9b\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n<\/section>\n<\/section>\n

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1.<\/strong><\/em><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1 \/ PD-L1\u963b\u6ede\u6cbb\u7597\u7684\u5e94\u7b54\u9884\u6d4b\u548c\u5f71\u54cd\u56e0\u7d20<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1.1 \u57fa\u56e0\u7a81\u53d8<\/strong><\/p>\n<\/section>\n

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    \u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u57fa\u56e0\u7ec4\u6539\u53d8\u4e0e\u80bf\u7624\u53d1\u751f\u548c\u5bf9PD-1\u6cbb\u7597\u7684\u5e94\u7b54\u5bc6\u5207\u76f8\u5173\u3002\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u662f\u8bc4\u4f30\u80bf\u7624\u514d\u75ab\u539f\u6027\u7684\u91cd\u8981\u6307\u6807\uff0c\u4e5f\u662f\u9884\u6d4b\u7ec6\u80de\u6bd2\u6027\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff08CTLA-4\uff09\u548cPD-1\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u6548\u679c\u7684\u65b0\u5174\u751f\u7269\u6807\u5fd7\u7269\u3002TMB\u4e0e\u6297PD-1 \/ PD-L1\u514d\u75ab\u7597\u6cd5\u53cd\u5e94\u4e4b\u95f4\u7684\u76f8\u5173\u7cfb\u6570\u4e3a0.74\uff0c\u8fd9\u4e2a\u6570\u636e\u8868\u660e\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\uff08ORR\uff09\u5dee\u5f02\u670955\uff05\u7684\u53ef\u80fd\u4e0eTMB\u6709\u5173\u3002\u5c3d\u7ba1\u53ef\u80fd\u6ca1\u6709\u7edf\u4e00\u7684\u6807\u51c6\u6765\u5b9a\u4e49\u9ad8TMB\uff0c\u4f46\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08MMR-d\uff09\u548c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u7684\u80bf\u7624\u5bf9ICI\u6cbb\u7597\u8868\u73b0\u51fa\u660e\u663e\u7684\u53cd\u5e94\u3002\u5e26\u6709MMR-d\u7684\u80bf\u7624\u53ef\u901a\u8fc7\u5fae\u536b\u661f\u4e2d\u7684\u5e8f\u5217\u6539\u53d8\u79ef\u805a\u6210\u5343\u4e0a\u4e07\u7684\u7a81\u53d8\uff0c\u8fd9\u4f7f\u80bf\u7624\u5177\u6709\u514d\u75ab\u539f\u6027\u5e76\u5bf9ICI\u6cbb\u7597\u654f\u611f\u3002\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u4e8e2017\u5e74\u6279\u51c6\u5c06Pembrolizumab\u548cNivolumab\u7528\u4e8e\u6cbb\u7597MSI\u9ad8\u6216MMR-d\u9ad8\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1.2 PD-1\u914d\u4f53\u7684\u8868\u8fbe<\/strong><\/p>\n<\/section>\n

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    \u9776\u5411PD-1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5305\u62ec\u9488\u5bf9PD-1\u7684\u6297\u4f53\uff0c\u8fd9\u79cd\u6297\u4f53\u53ef\u963b\u65adPD-1\u4e0e\u5176\u914d\u4f53PD-L1\u548cPD-L2\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5df2\u6709\u62a5\u9053\u79f0PD-1\u914d\u4f53\u5728\u5b9e\u4f53\u7624\u4e2d\u7684\u8868\u8fbe\u662fPD-1\/PD-L1\u6291\u5236\u5242\u53d6\u5f97\u8f83\u597d\u7597\u6548\u7684\u751f\u7269\u9884\u6d4b\u6807\u5fd7\u7269\u3002PD-1\u914d\u4f53\u5728\u591a\u80bf\u7624\u7ec6\u80de\u548c\u9aa8\u9ad3\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\uff0c\u5e76\u4e14\u5bf9\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u8fdb\u884c\u7814\u7a76\u540e\u53d1\u73b0PD-L1\u8fc7\u8868\u8fbe\u4e0eICI\u5e94\u7b54\u76f8\u5173\u3002FDA\u5df2\u7ecf\u6279\u51c6PD-L1\u514d\u75ab\u7ec4\u5316\u4f5c\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u6297PD-1\u6cbb\u7597\u7684\u8f85\u52a9\u8bca\u65ad\u6307\u6807\u3002\u4e5f\u6709\u6587\u732e\u62a5\u9053\u6765\u81ea\u67d0\u4e9b\u80bf\u7624\u91ca\u653e\u7684PD-1\u5916\u6ccc\u4f53\u7684PD-1\u914d\u4f53\u53c2\u4e0e\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u9003\u9038\u3002\u5728\u5927\u80a0\u764c\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u8054\u5408\u4f7f\u7528PD-L1\u6297\u4f53\u548c\u6291\u5236PD-L1\u5916\u6ccc\u4f53\u5206\u6ccc\u7684\u836f\u7269\u53ef\u4ee5\u8fbe\u5230\u6291\u5236\u80bf\u7624\u7684\u4f5c\u7528\u3002PD-L1\u5916\u6ccc\u4f53\u4e5f\u662f\u4e00\u4e2a\u6f5c\u5728\u7684\u514d\u75ab\u6cbb\u7597\u9776\u70b9\uff0c\u53ef\u4ee5\u89e3\u51b3\u76ee\u524dPD-L1\u6297\u4f53\u6cbb\u7597\u7684\u8010\u836f\u6027\u3002PD-L1\u5916\u6ccc\u4f53\u6c34\u5e73\u53ef\u9884\u793a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6fc0\u6d3bT\u7ec6\u80de\u7684\u6c34\u5e73\uff0c\u4e5f\u53ef\u4f5c\u4e3a\u4e00\u4e2a\u9884\u540e\u6307\u6807\u3002PD-1\u7684\u53e6\u4e00\u79cd\u5df2\u77e5\u914d\u4f53PD-L2\u7684\u9633\u6027\u8868\u8fbe\u6e05\u6670\u5730\u9884\u6d4b\u4e86Pembrolizumab\u7684\u4e34\u5e8a\u7597\u6548\uff0c\u5f53\u7136\u8fd8\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u6765\u786e\u5b9aPD-L2\u5728PD-1\u963b\u65ad\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1.3 \u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u7684\u5f02\u8d28\u6027<\/strong><\/p>\n<\/section>\n

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    \u80bf\u7624\u5fae\u73af\u5883\u662f\u4e00\u4e2a\u7531\u4e0d\u540c\u7ec6\u80de\u548c\u5206\u5b50\u7ec4\u6210\u7684\u5177\u6709\u5f02\u8d28\u6027\u7684\u514d\u75ab\u6291\u5236\u6027\u7684\u73af\u5883\u3002\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de(TILs)\u7684\u5bc6\u5ea6\u3001\u8868\u578b\u548c\u591a\u6837\u6027\u5bf9ICI\u53cd\u5e94\u81f3\u5173\u91cd\u8981\u3002\u5bf9\u4e8e\u67d0\u4e9b\u7c7b\u578b\u7684\u80bf\u7624\uff0cTIL\u6c34\u5e73\u662fICI\u5e94\u7b54\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002\u8bb8\u591a\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u4e5f\u53ef\u80fd\u5f71\u54cd\u6297PD-1\/PD-L1\u6cbb\u7597\u7684\u7597\u6548\u3002\u4eba\u9ed1\u7d20\u7624\u523a\u6fc0\u6027\u6811\u7a81\u72b6\u7ec6\u80de\uff08SDC\uff09\u7684\u6570\u91cf\u53ef\u4ee5\u9884\u6d4b\u60a3\u8005\u7684\u514d\u75ab\u53cd\u5e94\u548c\u603b\u751f\u5b58\u7387\uff08OS\uff09\uff0c\u800cSDC\u4e30\u5ea6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50\u6709\u5173\uff0c\u5c24\u5176\u662f\u4eba\u7c7b\u80bf\u7624\u4e2d\u7684\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u80bf\u7624\u4e2dNK\u7ec6\u80de\u7684\u5b58\u5728\u4e0eSDCs\u6570\u91cf\u7684\u589e\u52a0\u548c\u60a3\u8005\u5bf9PD-1\u6297\u4f53\u7684\u957f\u671f\u5e94\u7b54\u6709\u5173\u3002\u5728\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de(TAMs)\u7684\u5b58\u5728\u4e0e\u6297PD-1\u5e94\u7b54\u8f83\u5dee\u6709\u5173\u3002\u5c3d\u7ba1\u6297PD-1\u6297\u4f53\u6700\u521d\u53ef\u4ee5\u50cf\u9884\u671f\u7684\u90a3\u6837\u4e0eT\u7ec6\u80de\u7ed3\u5408\uff0c\u4f46TAMs\u5f88\u5feb\u4f1a\u5c06\u8fd9\u4e9b\u6297\u4f53\u4eceT\u7ec6\u80de\u4e2d\u79fb\u9664\uff0c\u4ece\u800c\u4f7f\u5176\u5931\u6d3b\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u6df1\u5165\u4e86\u89e3\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u7684\u5f02\u8d28\u6027\u5bf9\u4e8e\u5f00\u53d1\u7075\u654f\u7684\u65b9\u6cd5\u6216\u53d1\u73b0\u6f5c\u5728\u7684\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u4ee5\u63d0\u4f9b\u80bf\u7624\u5fae\u73af\u5883\u7684\u5168\u90e8\u6307\u7eb9\u56fe\u8c31\uff0c\u8fdb\u800c\u63d0\u9ad8\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.<\/strong><\/em><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n
\n

\u7cfb\u7edf\u6027\u6548\u5e94<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n

2.1 \u80a5\u80d6<\/strong><\/p>\n<\/section>\n

\n
\n
\n

    \u80a5\u80d6\u4fc3\u8fdb\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\uff0c\u5e76\u4f34\u6709\u66f4\u9ad8\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u548c\u6f5c\u5728\u7684\u526f\u4f5c\u7528\u3002\u5728\u6d89\u53ca\u764c\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u80a5\u80d6\u4e5f\u88ab\u8bc1\u660e\u4e0ePD-1\/PD-L1\u963b\u6ede\u5242\u7684\u7597\u6548\u589e\u52a0\u6709\u5173\u3002\u4e00\u9879\u56de\u987e\u6027\u7814\u7a76\u53d1\u73b0\uff0c\u764c\u75c7\u60a3\u8005\u80a5\u80d6\u4e0eICIs\u7597\u6548\u6709\u5173\uff0c\u8d85\u91cd\/\u80a5\u80d6\u60a3\u8005\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u663e\u8457\u9ad8\u4e8e\u975e\u8d85\u91cd\u60a3\u8005\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u80a5\u80d6\u4e0e\u8377\u7624\u5c0f\u9f20\u548c\u4e34\u5e8a\u764c\u75c7\u60a3\u8005\u5bf9PD-L1\u53d7\u4f53\u963b\u6ede\u5242\u7597\u6548\u7684\u63d0\u9ad8\u6709\u5173\u3002\u4e73\u817a\u764c\u4e34\u5e8a\u524d\u8bd5\u9a8c\u53d1\u73b0\uff0c\u8102\u80aa\u7ec6\u80de\u8fc7\u5ea6\u8868\u8fbePD-L1\uff0c\u5f71\u54cd\u4e73\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u548c\u9884\u540e\uff0c\u5728\u6291\u5236\u8102\u80aa\u751f\u6210\u540e\u53ef\u9009\u62e9\u6027\u5730\u964d\u4f4e\u5c0f\u9f20\u8102\u80aa\u7ec4\u7ec7\u4e2dPD-L1\u7684\u8868\u8fbe\uff0c\u589e\u5f3aPD-L1\u6216PD-1\u6297\u4f53\u5728\u4e73\u817a\u764c\u6a21\u578b\u4e2d\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\uff0c\u4f53\u91cd\u6307\u6570(BMI) \u2265 25kg\/m2\u7684NSCLC\u60a3\u8005\u63a5\u53d7PD-L1\u6297\u4f53\u6cbb\u7597\u540e\uff0c\u6b7b\u4ea1\u7387\u663e\u8457\u964d\u4f4e(\u5c24\u5176\u662f\u5728PD-L1\u9ad8\u8868\u8fbe\u7684\u60c5\u51b5\u4e0b)\u3002\u6b64\u5916\uff0c\u53ef\u80fd\u8fd8\u6709\u5176\u4ed6\u672a\u77e5\u56e0\u7d20\u5f71\u54cd\u80a5\u80d6\u60a3\u8005\u5bf9ICI\u6cbb\u7597\u7684\u53cd\u5e94\uff0c\u6bd4\u5982\u514d\u75ab\u7ec6\u80de\u7684\u529f\u80fd\u548c\u4ee3\u8c22\u72b6\u6001\uff0c\u8fd9\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.2 \u80a0\u9053\u5fae\u751f\u7269\u7fa4<\/strong><\/p>\n<\/section>\n

\n
\n
\n

    \u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\u8fdb\u884c\u7684\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u4e34\u5e8a\u524d\u8bd5\u9a8c\u8868\u660e\uff0c\u5fae\u751f\u7269\u7fa4\u53ef\u80fd\u4f1a\u5f71\u54cd\u67d0\u4e9b\u7c7b\u578b\u764c\u75c7\u6cbb\u7597\u7684\u7597\u6548\uff0c\u7279\u522b\u662f\u514d\u75ab\u6cbb\u7597\u3002\u7814\u7a76\u4eba\u5458\u5206\u6790\u4e86\u63a5\u53d7\u6297PD-1\u514d\u75ab\u6cbb\u7597\u7684\u6709\u5e94\u7b54\u548c\u65e0\u5e94\u7b54\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u7caa\u4fbf\u5fae\u751f\u7269\uff0c\u53d1\u73b0\u4e24\u7ec4\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u7684\u591a\u6837\u6027\u548c\u4e30\u5bcc\u6027\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u53d1\u73b0\uff0c\u5e94\u7b54\u60a3\u8005\u7ec4\u7684\u80a0\u9053\u83cc\u7fa4\u589e\u5f3a\u4e86\u7cfb\u7edf\u514d\u75ab\u548c\u6297\u80bf\u7624\u514d\u75ab\uff1b\u540c\u65f6\uff0c\u63a5\u53d7\u5e94\u7b54\u60a3\u8005\u7caa\u83cc\u79fb\u690d\u7684\u65e0\u83cc\u5c0f\u9f20\u80bf\u7624\u6d88\u9000\u8fdb\u5c55\u826f\u597d\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u7caa\u83cc\u79fb\u690d\u53ef\u80fd\u4f1a\u6539\u5584PD-1\u7684\u7597\u6548\u4ee5\u53ca\u672a\u6765\u4e0e\u8010\u836f\u6027\u76f8\u5173\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

2.3 \u4e2d\u6027\u7c92\u7ec6\u80de\/\u6dcb\u5df4\u7ec6\u80de\u6bd4\u7387<\/strong><\/p>\n<\/section>\n

\n
\n
\n

    \u5728\u8bb8\u591a\u80bf\u7624\u6cbb\u7597\u4e2d\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de-\u6dcb\u5df4\u7ec6\u80de\u6bd4\u7387(NLR)\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u9884\u540e\u6807\u8bb0\u7269\uff1b\u8f83\u9ad8\u7684NLR\u8868\u660e\u5bbf\u4e3b\u708e\u75c7\uff0c\u5728\u4e00\u4e9b\u80bf\u7624\u7c7b\u578b\u4e2d\u4e0e\u8f83\u77ed\u7684\u603b\u751f\u5b58\u7387\u76f8\u5173\u3002\u5bf9\u6bd4PD-1\/PD-L1\u6291\u5236\u5242\u6cbb\u7597\u524d\u540eNLR\u503c\u53d1\u73b0\uff0cNLR\u578b\u2265 4\u60a3\u8005\u6cbb\u7597\u524d\u603b\u751f\u5b58\u7387\u548c\u75be\u75c5\u65e0\u8fdb\u5c55\u65f6\u95f4\u8f83\u77ed\uff0c\u6cbb\u75976\u5468\u540e\u7684NLR\u662f\u63a5\u53d7\u6297PD-1\u6297\u4f53\u6cbb\u7597\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u9884\u540e\u6307\u6807\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u6cbb\u7597\u540e\u9ad8NLR\u5355\u72ec\u6216\u4e0e\u5176\u4ed6\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\u8054\u5408\u4f7f\u7528\u53ef\u4f5c\u4e3aICI\u6cbb\u7597\u4e2d\u603b\u751f\u5b58\u7387\u548c\u65e0\u8fdb\u5c55\u751f\u5b58(PFS)\u7684\u6709\u7528\u6307\u6807\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

2.4 \u7efc\u5408\u6cbb\u7597\u7b56\u7565<\/strong><\/p>\n<\/section>\n

\n
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    \u6700\u5e38\u89c1\u7684\u4e09\u79cd\u8054\u5408\u6cbb\u7597\u7b56\u7565\u662fPD1\/PD-L1\u6291\u5236\u5242\u8054\u5408CTLA-4\u5355\u6297\u3001\u5316\u7597\u548c\u9776\u5411\u6cbb\u7597\u3002FDA\u6279\u51c6\u4e86\u56db\u79cd\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff1a\u4e24\u79cd\u7528\u4e8e\u80be\u764c[Pembrolizumab (PD-1\u6297\u4f53)+Axitinib (VEGFR\/PDGFR\u6291\u5236\u5242)\u548cAvelumab(PD-L1\u6297\u4f53)+Axitinib]\uff0c\u4e00\u79cd\u7528\u4e8e\u5b50\u5bab\u5185\u819c\u764c[Pembrolizumab + lenvatinib (VEGFR\/FGFR\u6291\u5236\u5242)]\uff0c\u53e6\u4e00\u79cd\u7528\u4e8eNSCLC (Atezolizumab,  Bevacizumab\u548c\u5316\u7597)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

2.5 \u4e0eCTLA-4\u5355\u6297\u7ed3\u5408<\/strong><\/p>\n<\/section>\n

\n
\n
\n

    \u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff08CTLA-4\uff09\u5df2\u88ab\u8bc1\u660e\u5728\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u53cd\u5e94\u4e2d\u6709\u5f88\u5f3a\u7684\u6291\u5236\u4f5c\u7528\u3002\u7834\u574fCTLA-4-CD80\/CD86\u4e0e\u6297CTLA-4\u6297\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u901a\u8fc7\u589e\u5f3aT\u7ec6\u80de\u6548\u5e94\u53cd\u5e94\u800c\u5bfc\u81f4\u80bf\u7624\u6392\u65a5\u53cd\u5e94\u3002\u5173\u4e8e\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684III\u671f\u8bd5\u9a8cCheckMate067\u5728Nivolumab(PD-1\u6297\u4f53)+Ipilimumab(CTLA-4\u6297\u4f53)\u7ec4\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u548c\u603b\u751f\u5b58\u7387\u663e\u8457\u6539\u5584\u3002\u4e0eCTLA-4\u548cPD-1\u5355\u72ec\u6cbb\u7597\u76f8\u6bd4\uff0c\u4e24\u79cd\u836f\u7269\u8054\u5408\u6cbb\u7597\u7684\u6b7b\u4ea1\u98ce\u9669\u5206\u522b\u964d\u4f4e46%\u548c35%\u3002\u5728\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\uff0c21%\u7684\u60a3\u8005\u75c5\u7076\u5b8c\u5168\u6d88\u5931\u5b9e\u73b0\u4e86\u5b8c\u5168\u7f13\u89e3\uff0c37%\u7684\u60a3\u8005\u75c5\u7076\u51cf\u5c11\u4e8630%\u5e76\u5b9e\u73b0\u4e86\u90e8\u5206\u7f13\u89e3\u3002\u4f46\u662f\uff0c\u8054\u5408\u6cbb\u7597\u7ec459%\u7684\u60a3\u8005\u62a5\u544a\u4e863-4\u6b21\u4e0d\u826f\u53cd\u5e94\u3002\u5728KEYNOTE-006\u7814\u7a76\u4e2d\uff0cKeytruda\u8054\u5408\u6cbb\u7597\u7ec4\u548cIpilimumab\u5355\u836f\u6cbb\u7597\u76845\u5e74\u751f\u5b58\u7387\u5206\u522b\u4e3a38.7%\u548c31%\u3002\u4e24\u79cd\u514d\u75ab\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u7684\u6548\u679c\u66f4\u597d\uff0c\u4f46\u6cbb\u7597\u8d39\u7528\u53ca\u526f\u4f5c\u7528\u5747\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

2.6 \u8054\u5408\u5316\u7597\u548c\u653e\u7597<\/strong><\/p>\n<\/section>\n

\n
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    \u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u5316\u7597\u548c\u653e\u7597\u5177\u6709\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u30022018\u5e74\uff0c\u7f8e\u56fdFDA\u6b63\u5f0f\u6279\u51c6PD-1\u6297\u4f53Keytruda\u7ed3\u5408\u5316\u7597\u4f5c\u4e3aNSCLC\u7684\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\uff0c\u4e0d\u8003\u8651\u60a3\u8005\u7684PD-L1\u8868\u8fbe\u6c34\u5e73\uff08\u4e0d\u5305\u62ecEGFR\u7a81\u53d8\u548cALK\u878d\u5408\u7684\u60a3\u8005)\u3002\u5728616\u540d\u60a3\u8005\u4e2d\uff0c410\u540d\u60a3\u8005\u63a5\u53d7\u4e86PD-1\u8054\u5408\u6cbb\u7597\uff0c\u4f7f\u7528Keytruda+\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u836f\u7269\uff1b\u5176\u4f59206\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u5b89\u6170\u5242+\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\u836f\u7269\u7684\u5316\u7597\u3002\u7ecf\u8fc710.5\u4e2a\u6708\u7684\u968f\u8bbf\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u5728\u5404\u65b9\u9762\u5747\u5177\u6709\u538b\u5012\u6027\u4f18\u52bf\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u9ad8\u8fbe47.6%\uff0c\u800c\u5316\u7597\u7ec4\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u4e3a18.9%\uff0c\u8054\u5408\u6cbb\u7597\u5c06\u75be\u75c5\u8fdb\u5c55\u7684\u98ce\u9669\u964d\u4f4e\u4e8648%\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u65e0\u8bbaPD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u60a3\u8005\u751f\u5b58\u671f\u5747\u660e\u663e\u5ef6\u957f\u3002\u540c\u65f6\uff0c\u8bb8\u591a\u4e0ePD-1\u6291\u5236\u5242\u8054\u5408\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u53d6\u5f97\u4e86\u8bb8\u591a\u4ee4\u4eba\u632f\u594b\u7684\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

2.7 \u4e0e\u9776\u5411\u6cbb\u7597\u76f8\u7ed3\u5408<\/strong><\/p>\n<\/section>\n

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    \u9776\u5411\u836f\u7269\u9ad8\u6548\u4f46\u5bb9\u6613\u4ea7\u751f\u8010\u836f\u6027\u3002\u56e0\u6b64\uff0c\u9776\u5411\u836f\u7269\u4e0eICIs\u8054\u5408\u5e94\u7528\u53ef\u53d6\u5f97\u9ad8\u6548\u3001\u957f\u6548\u7684\u6cbb\u7597\u6548\u679c\u3002\u7f8e\u56fdFDA\u6279\u51c6PD-1\u6297\u4f53Keytruda\u4e0eAxitinib\u8054\u5408\u6cbb\u7597\u665a\u671f\u80be\u764c\u3002\u8fd9\u662f\u9996\u4f8bPD-1\u6297\u4f53\u4e0e\u9776\u5411\u6cbb\u7597\u8054\u5408\u7597\u6cd5\uff0c\u6b63\u5f0f\u5f00\u542f\u4e86\u80bf\u7624\u6cbb\u7597\u201c\u514d\u75ab+\u9776\u5411\u201d\u65b0\u7eaa\u5143\u3002KEYNOTE-426\u7684\u7b2c\u4e09\u4e34\u5e8a\u9636\u6bb5\u5b9e\u9a8c\u62db\u52df\u4e86\u4e16\u754c\u591a\u4e2a\u56fd\u5bb6\u7684\u80be\u764c\u60a3\u8005\uff0c\u66f4\u8fdb\u4e00\u6b65\u8bc4\u4f30Keytruda\u8054\u5408Axitinib\u7684\u7597\u6548\uff0c\u5176\u4e2dAxitinib\u662f\u9009\u62e9\u6027\u6291\u5236\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(VEGFR-1\u3001VEGFR-2\u3001VEGFR-3)\u7b2c\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002Pembrolizumab+Axitinib\u7ec4\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u9ad8\u8fbe59.3%\uff0c\u800cSunitinib\uff08\u8212\u5c3c\u66ff\u5c3c\uff09\u7ec4\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\u4ec5\u4e3a35.7%\u3002Sunitinib\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\u591a\u9776\u70b9\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002Sunitinib\u7ec4\u548c\u8054\u5408\u7528\u836f\u7ec4\u7684PFS\u5206\u522b\u4e3a11.1\u4e2a\u6708\u548c15.1\u4e2a\u6708\uff0c\u6b7b\u4ea1\u6216\u8fdb\u5c55\u7684\u98ce\u9669\u964d\u4f4e\u4e8631%\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u548cSunitinib\u7ec4\u768412\u4e2a\u6708\u5b58\u6d3b\u7387\u5206\u522b\u4e3a89.9%\u548c78.3%\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8647%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.<\/strong><\/em><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

PD-1\/PD-L1\u53d7\u4f53\u963b\u65ad\u5242\u7684\u526f\u4f5c\u7528\u53ca\u8010\u836f\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

    PD-1\/PD-L1\u6297\u4f53\u6cbb\u7597\u9762\u4e34\u7684\u65b0\u6311\u6218\u662f\u4e0d\u540c\u7a0b\u5ea6\u7684\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6(irAEs)\uff0c\u5176\u4e2d\u5305\u62ec\u5fc3\u810f\u6bd2\u6027\uff0c\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff0c\u5fc3\u808c\u708e\uff0c\u80ba\u708e\uff0c\u809d\u708e\uff0c\u7532\u72b6\u817a\u708e\uff0c\u5185\u5206\u6ccc\u529f\u80fd\u969c\u788d\uff0c\u75b2\u52b3\u3001\u76ae\u75b9\u548c\u8179\u6cfb\uff0c\u4ee5\u53ca\u98ce\u6e7f\u6027\u591a\u808c\u75db\/\u5de8\u7ec6\u80de\u52a8\u8109\u708e\u3002\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u901a\u5e38\u8d77\u6e90\u4e8e\u76ae\u80a4\u3001\u80c3\u80a0\u9053\u3001\u809d\u810f\u548c\u5185\u5206\u6ccc\u7cfb\u7edf\uff0c\u5c3d\u7ba1\u5176\u4ed6\u5668\u5b98\u7cfb\u7edf\u4e5f\u53ef\u80fd\u53d7\u5230\u5f71\u54cd\uff0cMartins\u7b49\u4eba\u603b\u7ed3\u4e86\u4e0d\u540c\u7c7b\u578b\u7684irAEs\uff0c\u5e76\u8ba8\u8bba\u8fd9\u4e9b\u4e0d\u826f\u4e8b\u4ef6\u7684\u6d41\u884c\u75c5\u5b66\u548c\u52a8\u529b\u5b66\u3001\u5371\u9669\u56e0\u7d20\u3001\u4e9a\u578b\u3001\u75c5\u7406\u751f\u7406\u5b66\u4ee5\u53ca\u7b5b\u67e5\u548c\u76d1\u6d4b\u7b56\u7565\uff0c\u5e76\u5f3a\u8c03\u4e86\u76d1\u7ba1irAEs\u7684\u91cd\u8981\u4f5c\u7528\u3002\u76ee\u524d\u5df2\u7ecf\u6709\u51e0\u4e2a\u5173\u4e8eirAEs\u76d1\u7ba1\u7684\u6307\u5357\u3002<\/p>\n

    \u5c3d\u7ba1\u514d\u75ab\u7597\u6cd5\u662f\u4e00\u79cd\u957f\u6548\u7597\u6cd5\uff0c\u4f46\u5b83\u4e5f\u4f1a\u4ea7\u751f\u8010\u836f\u6027\u3002\u5728\u4e00\u9879\u9488\u5bf9205\u4f8b\u4f7f\u7528Keytruda\u6709\u6548\u7684\u60a3\u8005\u7684\u7814\u7a76\u4e2d\uff0c\u7ecf\u8fc721\u4e2a\u6708\u7684\u968f\u8bbf\uff0c\u53d1\u73b074%\u7684\u60a3\u8005\u4ecd\u7136\u6709\u6548\uff0c\u800c26%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u8010\u836f\u6027\u3002\u540c\u6837\uff0c\u5728\u5bf942\u4f8bPD-1\u80fd\u6709\u6548\u6cbb\u7597\u7684\u6076\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8fdb\u884c\u957f\u671f\u968f\u8bbf\u540e\uff0c15\u4f8b\u60a3\u8005\u51fa\u73b0\u4e86\u8010\u836f\u6027\uff0c\u8010\u836f\u7387\u4e3a35%\u3002CMP-001(Checkmate\u5236\u836f\u516c\u53f8\uff0c\u4e2d\u56fd\u8fde\u4e91\u6e2f)\u662f\u4e00\u79cd\u6b63\u5728\u7814\u7a76\u4e2d\u7684TLR9\u6fc0\u52a8\u5242\uff0c\u5b83\u53ef\u80fd\u4f1a\u51cf\u8f7b\u8fd9\u79cd\u8010\u836f\u6027\uff0c\u5e76\u4e14\u6709\u6548\u7387\u9ad8\u8fbe22%\uff0c\u5305\u62ec\u90e8\u5206\u80bf\u7624\u75c5\u7076\u7684\u6d88\u5931\u3002<\/p>\n

    \u9664\u4e86FDA\u6279\u51c6\u7684\u65b9\u6cd5\u4e4b\u5916\uff0c\u8fd8\u6709\u8bb8\u591a\u6f5c\u5728\u7684\u53d1\u73b0\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u83b7\u5f97\u53ef\u559c\u7684\u7ed3\u679c\u3002Ipilimumab\u4e0eNivolumab\u8054\u5408\u514d\u75ab\u6cbb\u7597\u540e\u7ed3\u80a0\u708e\u60a3\u8005\u80a0\u9053\u4e2d\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09\u7684\u4e0a\u8c03\u3002\u5728\u4eba\u5de5\u8bf1\u5bfc\u7684\u5c0f\u9f20\u708e\u75c7\u6027\u80a0\u75c5\u6a21\u578b\u4e2d\uff0c\u6297CTLA-4\u548c\u6297PD-1\u53cc\u91cd\u6cbb\u7597\u4f1a\u52a0\u91cd\u708e\u75c7\u53cd\u5e94\u3002\u9884\u9632\u6027TNF\u6297\u4f53\u6216TNF\u6291\u5236\u5242(TNFR2-IgG)\u53ef\u663e\u8457\u51cf\u5c11\u7531\u53cc\u91cd\u68c0\u67e5\u70b9\u963b\u65ad\u6240\u81f4\u7684\u7ed3\u80a0\u708e\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u53d1\u73b0\uff0c\u963b\u65adTNF\u53ef\u8fdb\u4e00\u6b65\u589e\u5f3a\u6297PD-1\u548c\u6297CTLA-4\u5355\u6297\u8054\u5408\u6cbb\u7597\u5f15\u8d77\u7684\u80bf\u7624\u7279\u5f02\u6027CD8+T\u7ec6\u80de\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7684\u6d78\u6da6\u548c\u6dcb\u5df4\u5f15\u6d41\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e00\u9879I\u671f\u4e34\u5e8a\u5b9e\u9a8c\u6765\u6d4b\u8bd5\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n

4.<\/strong><\/em><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u7ed3\u675f\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

    \u4f7f\u7528PD1\/PD-L1\u6297\u4f53\u5df2\u6210\u4e3a10\u4f59\u79cd\u80bf\u7624\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u76ee\u524d\uff0c\u5df2\u67099\u79cd\u6297\u4f53\u88ab\u6279\u51c6\u5728\u5168\u7403\u4e0a\u5e02\uff0c\u5927\u91cf\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8bc4\u4f30PD-1\/PD-L1\u6297\u4f53\u4f5c\u4e3a\u5355\u836f\u6216\u8054\u5408\u4f7f\u7528\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u4e2a\u4f53\u5316\u6cbb\u7597\u7684\u5b58\u5728\u7ed9\u901a\u8fc7\u5355\u4e00\u8bca\u65ad\u6307\u6807\u9884\u6d4b\u63a5\u53d7ICIs\u6cbb\u7597\u7684\u60a3\u8005\u7684\u9884\u540e\u6216\u5b58\u6d3b\u7387\u5e26\u6765\u4e86\u5de8\u5927\u7684\u56f0\u96be\uff0c\u9700\u8981\u7efc\u5408\u591a\u79cd\u4fe1\u606f\u7684\u65b0\u6807\u8bb0\u7269\u6216\u7ec4\u7fa4\u6765\u9884\u6d4b\u6297PD-1\/PD-L1\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u3002\u514d\u75ab\u6cbb\u7597\u9700\u8981\u5b9e\u65f6\u8ffd\u8e2a\u514d\u75ab\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u975e\u4fb5\u5165\u6027\u68c0\u6d4b\u7684\u65b9\u6cd5\u8bc4\u4f30\u80bf\u7624\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u5e94\u7b54\u3002\u76ee\u524d\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u6d3b\u68c0\u6216\u624b\u672f\u5207\u9664\u80bf\u7624\u6837\u672c\u8fdb\u884c\u68c0\u6d4b\uff0c\u5982\u679c\u80fd\u5728\u8840\u6db2\u4e2d\u627e\u5230\u76f8\u5173\u7684\u68c0\u6d4b\u56e0\u7d20\uff0c\u5bf9\u4e8e\u786e\u5b9a\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u6709\u6548\u6027\u548c\u53cd\u5e94\u6027\u5c06\u5177\u6709\u91cd\u5927\u610f\u4e49\u3002\u4f53\u5916\u7814\u7a76\u6a21\u578b\u9700\u8981\u66f4\u63a5\u8fd1\u4eba\u4f53\u7684\u72b6\u6001\uff0c\u6bd4\u5982\u7ed3\u5408\u514d\u75ab\u5fae\u73af\u5883\u7684\u6709\u673a\u5316\u5408\u7269\u3002\u540c\u65f6\uff0c\u6709\u673a\u5316\u5408\u7269\u53ef\u4ee5\u66f4\u597d\u5730\u63ed\u793a\u80bf\u7624\u7684\u8fdb\u5c55\u548c\u8010\u836f\u6027\uff0c\u4e3a\u672a\u6765\u7684\u6297\u764c\u836f\u7269\u7b5b\u9009\u505a\u51fa\u8d21\u732e\u3002<\/p>\n

    \u514d\u75ab\u7597\u6cd5\u4e3a\u7cbe\u51c6\u6cbb\u7597\u6076\u6027\u80bf\u7624\u5f00\u8f9f\u4e86\u9053\u8def\u3002\u76ee\u524dICIs\u9700\u8981\u514b\u670d\u7684\u95ee\u9898\u5305\u62ec\uff1a\u5bf9\u654f\u611f\u4eba\u7fa4\u7684\u51c6\u786e\u7b5b\u67e5\uff0c\u5f00\u5c55\u5b9e\u65f6\u52a8\u6001\u7597\u6548\u76d1\u6d4b\u7cfb\u7edf\uff0c\u53d1\u5c55\u8f85\u52a9\u8bca\u65ad\u6280\u672f\u548c\u65b9\u6cd5\u7684\uff0c\u5f00\u53d1\u9ad8\u901a\u91cf\u591a\u5206\u5b50\u591a\u56e0\u7d20\u7efc\u5408\u5206\u6790\u65b9\u6cd5\uff0c\u4ee5\u53ca\u5e8f\u8d2f\u6cbb\u7597\u7684\u53d1\u5c55\u7b49\u3002\u6539\u5584PD-1\u963b\u6ede\u6cbb\u7597\u7684\u5173\u952e\u662f\u53d1\u5c55\u8054\u5408\u6cbb\u7597\uff0c\u5305\u62ecT\u7ec6\u80de\u6216\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u7684\u5176\u4ed6\u68c0\u67e5\u70b9\uff0c\u5982CTLA-4\u548cNKG2D\u3002\u6b64\u5916\uff0c\u8fd8\u9700\u8981\u63a2\u7d22\u5206\u5b50\u6807\u5fd7\u7269\u4ee5\u6307\u5bfc\u4e34\u5e8a\u6cbb\u7597\uff0c\u4f8b\u5982PD-L1\u3001TMB\u3001MSI\u548cTIL\u3002\u514d\u75ab\u80bf\u7624\u5b66\u7684\u4e0b\u4e00\u6b65\u7814\u7a76\uff1a\u901a\u8fc7\u9009\u62e9\u5408\u9002\u7684\u60a3\u8005\u548c\u5408\u7406\u8bbe\u8ba1\u7684\u8054\u5408\u4f5c\u7528\u6765\u63d0\u9ad8\u6297\u80bf\u7624\u6548\u679c\u3002\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7684\u5e94\u7528\u63ed\u793a\u4e86\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f02\u8d28\u6027\uff0c\u8fd9\u6709\u52a9\u4e8e\u66f4\u597d\u5730\u4e86\u89e3\u80bf\u7624\u7684\u53d1\u5c55\u548c\u514d\u75ab\u9003\u9038\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n

5.<\/strong><\/em><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u58f0\u660e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

    \u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\uff0c<\/span>\u5982\u9700\u8f6c\u8f7d\u8bf7\u8054\u7cfb\u672c\u516c\u4f17\u53f7\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/span><\/p>\n

<\/span><\/section>\n

\u2014 THE  END \u2014<\/span><\/p>\n

\u6765\u6e90 | <\/strong><\/span>Front Immunol.<\/span><\/section>\n
\u6267\u884c\u7f16\u8f91 | <\/strong>\u5f90\u66fc\u65af \u848b\u4fca\u535a \u7f57\u4f73\u4f73 \u90d1\u68a6\u6021<\/span><\/section>\n
\u8d23\u4efb\u7f16\u8f91 |<\/strong> \u949f\u96ea\u83b9
<\/span><\/section>\n
\u5ba1\u6838 | <\/strong>\u5b8b  \u4e50<\/span><\/section>\n
\u5ba1\u5b9a |<\/strong> \u738b  \u5764<\/span><\/section>\n

<\/section>\n
\u5f80\u671f\u6587\u7ae0\u63a8\u8350<\/strong>
<\/section>\n
\n
\n
\n
\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a> <\/span><\/p>\n

\u79d1\u7814 | Cell Metab.\uff1a\u8102\u8d28\u4ee3\u8c22\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528<\/a>
<\/span><\/p>\n

\u7efc\u8ff0 | \u5fae\u751f\u7269-\u80a0-\u8111\u8f74\uff1a\u4e2d\u67a2\u795e\u7ecf\u75be\u75c5\u65b0\u7684\u6cbb\u7597\u601d\u8def<\/a>
<\/span><\/p>\n

BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a><\/p>\n

BD Accuri C5\u6d41\u5f0f\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a>
<\/p>\n

BD FACSJAZZ\u6d41\u5f0f\u7ec6\u80de\u5206\u9009\u4eea\u57fa\u672c\u53c2\u6570\u53ca\u5e94\u7528\u7b80\u4ecb<\/span><\/a>
<\/p>\n

BD Accuri C5\u6d41\u5f0f\u7ec6\u80de\u4eea\u4f7f\u7528\u89c4\u8303\u53ca\u64cd\u4f5c\u6d41\u7a0b<\/span><\/a>
<\/p>\n

\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a><\/p>\n

WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a>
<\/p>\n

Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a>
<\/p>\n

\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a>
<\/p>\n

ZESS Axio Observer3\u5012\u7f6e\u8367\u5149\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/span><\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/span><\/a>
<\/p>\n

Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/span><\/a>
<\/p>\n

\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/span><\/a>
<\/p>\n

PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/span><\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/span><\/a>
<\/p>\n

\u5982\u4f55\u6d4b\u91cfWestern Blot\u6761\u5e26\u7070\u5ea6\u503c\uff1f(GelPro\u8f6f\u4ef6\u4f7f\u7528\u65b9\u6cd5)<\/span><\/a>
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