{"id":3289,"date":"2020-11-18T18:47:31","date_gmt":"2020-11-18T10:47:31","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2020\/11\/18\/%e7%a7%91%e7%a0%94-cell-metab-%ef%bc%9a%e8%84%82%e8%b4%a8%e4%bb%a3%e8%b0%a2%e5%9c%a8%e7%99%8c%e7%97%87%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8\/"},"modified":"2022-05-01T22:17:26","modified_gmt":"2022-05-01T14:17:26","slug":"%e7%a7%91%e7%a0%94-cell-metab-%ef%bc%9a%e8%84%82%e8%b4%a8%e4%bb%a3%e8%b0%a2%e5%9c%a8%e7%99%8c%e7%97%87%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2020\/11\/18\/%e7%a7%91%e7%a0%94-cell-metab-%ef%bc%9a%e8%84%82%e8%b4%a8%e4%bb%a3%e8%b0%a2%e5%9c%a8%e7%99%8c%e7%97%87%e4%b8%ad%e7%9a%84%e4%bd%9c%e7%94%a8\/","title":{"rendered":"\u79d1\u7814 | Cell Metab.\uff1a\u8102\u8d28\u4ee3\u8c22\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528"},"content":{"rendered":"<div class=\"wxsyncmain\">\n<p style=\"text-align: center; color: #333333; clear: both; box-sizing: border-box; background-color: #ffffff;\">\n<p style=\"text-align: left; color: #333333; clear: both; box-sizing: border-box; background-color: #ffffff;\">\n<section style=\"color: #333333; box-sizing: border-box; background-color: #ffffff;\" data-id=\"85559\" data-tools=\"135\u7f16\u8f91\u5668\">\n<section style=\"border-color: #8dadaa; margin: 30px auto 0px; padding: 0px 10px 5px; border-radius: 15px; text-align: center; color: #fefefe; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #8dadaa;\"><span style=\"margin: 0px; padding: 0px; color: #000000; letter-spacing: 0.54px; font-family: \u5b8b\u4f53; font-size: 16px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\u5bfc\u8bfb<\/span><\/p>\n<section style=\"border-color: #8dadaa; margin: 0px 0px 5px; padding: 10px; border-radius: 15px; text-align: left; color: inherit; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #fefefe;\" data-style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-align: left; text-indent: 2em;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u8102\u8d28<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u662f\u4e00\u7c7b\u9ad8\u5ea6\u590d\u6742\u7684\u751f\u7269\u5206\u5b50\uff0c\u4e0d\u4ec5\u662f\u6784\u6210\u751f\u7269\u819c\u7684\u57fa\u7840\u7ed3\u6784\uff0c\u800c\u4e14\u8fd8\u662f\u4fe1\u53f7\u5206\u5b50\u548c\u80fd\u91cf\u6765\u6e90\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u8102\u8d28\u4ee3\u8c22\u6539\u53d8\u662f\u764c\u75c7\u4e2d\u6700\u7a81\u51fa\u7684\u4ee3\u8c22\u6539\u53d8\u4e4b\u4e00\uff0c<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u8102\u8d28\u5408\u6210\u6216\u6444\u53d6\u7684\u589e\u5f3a\u6709\u52a9\u4e8e\u764c\u7ec6\u80de\u7684\u5feb\u901f\u751f\u957f\u548c\u80bf\u7624\u7684\u5f62\u6210\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u672c\u7efc\u8ff0\u603b\u7ed3\u4e86\u8102\u8d28\u4ee3\u8c22\u6539\u53d8\u6d89\u53ca\u5230\u7684\u4e0d\u540c\u764c\u75c7\u8868\u578b\u7684\u6700\u65b0\u7814\u7a76\uff0c\u63a2\u8ba8\u9776\u5411\u8102\u8d28\u4ee3\u8c22\u4e3a\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u6cbb\u7597\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left; color: #333333; text-indent: 0em; clear: both; box-sizing: border-box; background-color: #ffffff;\"><\/section>\n<section style=\"color: #333333; box-sizing: border-box; background-color: #ffffff;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; box-sizing: border-box;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px; padding: 0px; text-indent: 0em; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<section style=\"margin: 0px 10px; padding: 0px; display: flex; max-width: 100%; box-sizing: border-box; justify-content: center; overflow-wrap: break-word;\">\n<section style=\"border-width: 5px 1px 1px; border-style: solid; border-color: #959595; margin: 0px; padding: 5px 20px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\">\n<p style=\"margin: 0px; padding: 0px; text-align: left; letter-spacing: 1.5px; clear: both; min-height: 1em; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"box-sizing: border-box; color: #021eaa; font-family: \u5b8b\u4f53; font-size: 16px; letter-spacing: 0.54px; max-width: 100%; overflow-wrap: break-word; padding: 0px; margin: 0px;\">\u8bba\u6587ID<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><span style=\"color: #021eaa; padding: 0px; margin: 0px;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-size: 16px; padding: 0px; margin: 0px;\">\u539f\u540d\uff1a<\/span><\/strong><\/span><span style=\"color: #000000; font-size: 12pt; text-indent: 0em; line-height: 1.6;\">Greasing\u00a0the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer<\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><span style=\"color: #021eaa; padding: 0px; margin: 0px;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-size: 16px; padding: 0px; margin: 0px;\">\u8bd1\u540d\uff1a<\/span><\/strong><\/span><span style=\"color: black; font-size: 12pt;\">\u8102\u8d28\u4ee3\u8c22\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528<\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><span style=\"color: #021eaa; padding: 0px; margin: 0px;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-size: 16px; padding: 0px; margin: 0px;\">\u671f\u520a\uff1a<\/span><\/strong><\/span><span style=\"color: #000000; font-size: 16px;\"><span lang=\"EN-US\" style=\"font-size: 12.0pt;\"><span style=\"font-size: 16px;\">Cell Metabolism<\/span><\/span><\/span><span style=\"color: #000000; font-size: 16px; padding: 0px; margin: 0px;\"><br style=\"padding: 0px; margin: 0px;\" \/><\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\"><strong>IF\uff1a<\/strong><\/span><span style=\"color: #000000; font-size: 12pt;\"><span lang=\"EN-US\" style=\"font-size: 12.0pt;\"><span style=\"font-size: 16px;\">21.56<\/span><\/span><\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><span style=\"color: #021eaa; padding: 0px; margin: 0px;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-size: 16px; padding: 0px; margin: 0px;\">\u53d1\u8868\u65f6\u95f4\uff1a<\/span><\/strong><\/span><span style=\"color: #000000; font-size: 16px; padding: 0px; margin: 0px;\">2020.01<\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><span style=\"color: #021eaa; padding: 0px; margin: 0px;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-size: 16px; padding: 0px; margin: 0px;\">\u901a\u8baf\u4f5c\u8005\uff1a<\/span><\/strong><\/span><span style=\"color: #000000; font-size: 12pt;\"><span lang=\"EN-US\" style=\"font-size: 12.0pt;\">MarteinnThor Snaebjornsson;\u00a0SudhaJanaki-Raman;\u00a0AlmutSchulze<\/span><\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; text-indent: 0em; clear: both;\"><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\"><strong>\u901a\u8baf\u4f5c\u8005\u5355\u4f4d\uff1a<\/strong><\/span><span style=\"font-size: 12pt; text-indent: 0em; line-height: 1.6;\">\u897f\u5965\u591a<\/span><span style=\"font-size: 12pt; text-indent: 0em; line-height: 1.6;\">\u00b7<\/span><span style=\"font-size: 12pt; text-indent: 0em; line-height: 1.6;\">\u6ce2\u7ef4\u91cc\u7814\u7a76\u6240<\/span><span style=\"font-size: 12pt; text-indent: 0em; line-height: 1.6;\">;<\/span><span style=\"font-size: 12pt; text-indent: 0em; line-height: 1.6;\">\u5fb7\u56fd\u80bf\u7624\u7814\u7a76\u4e2d\u5fc3<\/span><span style=\"font-size: 12pt; text-indent: 0em; line-height: 1.6;\">&#8211;<\/span><span style=\"font-size: 12pt; text-indent: 0em; line-height: 1.6;\">\u80bf\u7624\u4ee3\u8c22\u548c\u5fae\u73af\u5883\u90e8<\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; text-align: left; color: #333333; text-indent: 2em; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u00a0<\/span><\/section>\n<section style=\"background-color: #ffffff; box-sizing: border-box; color: #333333;\">\n<section style=\"box-sizing: border-box; max-width: 100%; overflow-wrap: break-word; text-indent: 0em; padding: 0px; margin: 5px 0px 0px 0px;\">\n<section style=\"box-sizing: border-box; display: flex; justify-content: center; max-width: 100%; overflow-wrap: break-word; padding: 0px; margin: 0px 10px 0px 10px;\">\n<section style=\"box-sizing: border-box; max-width: 100%; overflow-wrap: break-word; border-width: 5px 1px 1px 1px; border-color: #959595; border-style: solid; padding: 5px 20px 5px 20px; margin: 0px;\">\n<p style=\"margin: 0px; padding: 0px; text-align: left; letter-spacing: 1.5px; clear: both; min-height: 1em; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"color: #021eaa; font-family: \u5b8b\u4f53; 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color: #333333; clear: both; box-sizing: border-box; margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word; background-color: #ffffff;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-family: \u5b8b\u4f53; font-size: 14px; line-height: 150%; padding: 0px; margin: 0px;\">PDH\uff1a\u4e19\u916e\u9178\u8131\u6c22\u9176\uff1bIDH\uff1a\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176\uff1bACLY\uff1aATP-\u67e0\u6aac\u9178\u88c2\u89e3\u9176\uff1bACSS2\uff1a\u4e59\u9170\u8f85\u9176A\u5408\u6210\u9176\uff1bACACA\uff1a\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176A\uff1bFASN\uff1a\u8102\u80aa\u9178\u5408\u9176\uff1bSCD\uff1a\u786c\u8102\u9170\u8f85\u9176A\u53bb\u9971\u548c\u9176\uff08\u03949\uff09\uff1bELOVL\uff1a\u8102\u80aa\u9178\u5ef6\u4f38\u9176\uff1bELOVL6\uff1a\u8102\u80aa\u9178\u5ef6\u4f38\u91766\uff1bLDLR\uff1a\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\uff1bFABP\uff1a\u8102\u80aa\u9178\u7ed3\u5408\u86cb\u767d\uff1bCD36\uff1a\u8102\u80aa\u9178\u8f6c\u4f4d\u9176\/\u6e05\u9664\u53d7\u4f53\uff1bFADS\uff1a\u8102\u80aa\u9178\u53bb\u9971\u548c\u9176\uff08\u03945\u6216\u03946\uff09\uff1bCOX\uff1a\u73af\u6c27\u5408\u9176\/\u524d\u5217\u817a\u7d20-\u5185\u8fc7\u6c27\u5316\u7269\u5408\u9176\uff1bGPAT\uff1a3-\u78f7\u9178\u7518\u6cb9\u9170\u57fa\u8f6c\u79fb\u9176\uff1bAGPAT\uff1a1-\u9170\u57fa\u7518\u6cb9-3-\u78f7\u9178O-\u9170\u57fa\u8f6c\u79fb\u9176\uff1bLPIN\uff1a\u78f7\u8102\u9178\u78f7\u9178\u9176LPIN1\uff1bDGAT\uff1a\u4e8c\u9170\u57fa\u7518\u6cb9O-\u9170\u57fa\u8f6c\u79fb\u9176\uff1bLPCAT\uff1a\u6eb6\u8840\u78f7\u8102\u9170\u80c6\u78b1\u9170\u57fa\u8f6c\u79fb\u9176\uff1bHSL\uff1a\u6fc0\u7d20\u654f\u611f\u6027\u8102\u80aa\u9176\uff1bPLA2\uff1a\u78f7\u8102\u9176A2\uff1bATX\uff1a\u6838\u82f7\u9178\u7126\u78f7\u9178\u91762\uff1bFA\uff1a\u8102\u80aa\u9178\uff1bSFA\uff1a\u9971\u548c\u8102\u80aa\u9178\uff1bMUFA\uff1a\u5355\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff1bPUFA\uff1a\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff1bAA\uff1a\u82b1\u751f\u56db\u70ef\u9178\uff1bDHA\uff1a\u4e8c\u5341\u4e8c\u78b3\u516d\u70ef\u9178\uff1bEPA\uff1a\u4e8c\u5341\u78b3\u4e94\u70ef\u9178\uff1bG3P\uff1a3-\u78f7\u9178\u7518\u6cb9\uff1bLPA\uff1a\u6eb6\u8840\u78f7\u8102\u9178\uff1bPA\uff1a\u78f7\u8102\u9178\uff1bDAG\uff1a\u4e8c\u9170\u57fa\u7518\u6cb9\uff1bTAG\uff1a\u4e09\u9170\u57fa\u7518\u6cb9\uff1bcytoC\uff1a\u7ec6\u80de\u8272\u7d20c;\u00a0 PC\uff1a\u78f7\u8102\u9170\u80c6\u78b1\uff1bPS\uff1a\u78f7\u8102\u9170\u4e1d\u6c28\u9178\uff1bPE\uff1a\u78f7\u8102\u9170\u4e59\u9187\u80fa\uff1bCL\uff1a\u5fc3\u78f7\u8102\uff1bLPC\uff1a\u6eb6\u8840\u78f7\u8102\u9170\u80c6\u78b1\uff1bPI\uff1a\u78f7\u8102\u9170\u808c\u9187\u3002<\/span><\/strong><\/p>\n<p><span style=\"font-size: 16px; font-family: \u5b8b\u4f53;\">\u00a0<\/span><\/p>\n<p><span style=\"font-size: 16px; font-family: \u5b8b\u4f53;\">\u00a0\u00a0 <\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">FAs\u5728\u819c\u7ed3\u6784\u3001\u80fd\u91cf\u4ee3\u8c22\u548c\u4fe1\u53f7\u4f20\u5bfc\u4e2d\u7684\u591a\u91cd\u4f5c\u7528\u51f8\u663e\u4e86\u63a7\u5236\u764c\u7ec6\u80deFA\u6c34\u5e73\u7684\u91cd\u8981\u6027\uff0cFA\u6c34\u5e73\u80fd\u901a\u8fc7FA\u5408\u6210\u3001\u4fee\u9970\u3001\u6444\u53d6\u3001\u4ee5\u53caFA\u4ece\u5176\u4ed6\u8102\u8d28\u7269\u79cd\u91ca\u653e\u6765\u8c03\u8282\u3002\u5728\u4ee5\u4e0b\u5404\u8282\u4e2d\uff0c\u6211\u4eec\u5c06\u8ba8\u8bba\u63a7\u5236\u764c\u7ec6\u80de\u4e2dFA\u4e30\u5ea6\u7684\u4e0d\u540c\u673a\u5236\u3002<\/span><\/p>\n<p><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">1. \u764c\u75c7\u4e2d\u7684\u8102\u8d28\u4f9b\u5e94<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u5927\u591a\u6570\u4f53\u7ec6\u80de\u6216\u4ece\u98df\u7269\u4e2d\u83b7\u53d6\u8102\u8d28\uff0c\u6216\u901a\u8fc7\u809d\u810f\u5408\u6210\u8102\u8d28\uff0c\u4f46\u7814\u7a76\u53d1\u73b0\u5404\u79cd\u764c\u75c7\u81ea\u8eab\u80fd\u91cd\u65b0\u6fc0\u6d3b\u8102\u80aa\u751f\u6210\uff0c\u4f7f\u5b83\u4eec\u66f4\u4e0d\u4f9d\u8d56\u4e8e\u5916\u90e8\u63d0\u4f9b\u7684\u8102\u8d28\u3002<\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u00a0<\/span><\/section>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">2.\u00a0\u8102\u80aa\u9178\u7684\u5408\u6210\uff0c\u4fee\u9970\u548c\u6444\u53d6<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">FAs\u662f\u7531\u7ec6\u80de\u8d28\u7684\u4e59\u9170\u8f85\u9176A\u5408\u6210\uff0c\u4e59\u9170\u8f85\u9176A\u662f\u7531\u8461\u8404\u7cd6\uff0c\u8c37\u6c28\u9170\u80fa\u6216\u918b\u9178\u76d0\u751f\u6210\uff0c\u4e59\u9170\u8f85\u9176A\u88ab\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176\uff08ACC1 \/ 2\uff0c\u4e5f\u79f0\u4e3aACACA \/ B\uff09\u6fc0\u6d3b\u5f62\u6210\u4e19\u4e8c\u9170\u8f85\u9176A\uff1b\u968f\u540e\u7531\u8102\u80aa\u9178\u5408\u9176\uff08FASN\uff09\u50ac\u5316\uff0c\u5f62\u621016\u78b3\u7684\u9971\u548cFA\u68d5\u6988\u9178\u916f\uff0c\u68d5\u6988\u9178\u916f\u7136\u540e\u901a\u8fc7\u8102\u80aa\u9178\u5ef6\u7533\u9176\uff08ELOVL1\u20137\uff09\u5ef6\u7533\uff0c\u5e76\u901a\u8fc7\u786c\u8102\u9170\u8f85\u9176A\u53bb\u9971\u548c\u9176\uff08\u5728\u4eba\u4e2d\u4e3aSCD\u548cSCD5\uff09\u6216\u8102\u80aa\u9178\u53bb\u9971\u548c\u9176\uff08FADS1\u20133\uff09\u53bb\u9971\u548c\uff0c\u5f62\u6210\u5305\u62ec18-\u78b3\u5355\u4e0d\u9971\u548cFA\u6cb9\u9178\u916f\uff08C18\uff1a1\uff09\uff08\u56fe1\uff09\u5728\u5185\u7684\u975e\u5fc5\u9700FAs\u7ec6\u80de\u6c60\u3002<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u4e0d\u540c\u764c\u75c7\u4e2dFA\u5408\u6210\u7684\u591a\u9879\u8bb0\u5f55\u548c\u7814\u7a76\u8868\u660e\uff0c\u8102\u80aa\u751f\u6210\u5bf9\u4e8e\u80bf\u7624\u751f\u957f\u81f3\u5173\u91cd\u8981\uff0c\u5e76\u4e14\uff0c\u591a\u79cd\u81f4\u764c\u4fe1\u53f7\u901a\u8def\u96c6\u4e2d\u5728FA\u5408\u6210\u4e0a\u3002PI3K \/ Akt\u4fe1\u53f7\u901a\u8def\u589e\u52a0\u4e86FA\u5408\u6210\u6240\u9700\u7684\u9176\u7684\u8868\u8fbe\uff08\u5728\u4e0b\u6587\u4e2d\u6709\u66f4\u8be6\u7ec6\u7684\u8ba8\u8bba\uff09\uff0c\u4f46\u540c\u65f6\u4e5f\u589e\u52a0\u4e86ATP-\u67e0\u6aac\u9178\u88c2\u89e3\u9176\uff08ACLY\uff09\u7684\u78f7\u9178\u5316\u548c\u6fc0\u6d3b\uff0cACLY\u80fd\u50ac\u5316\u7ec6\u80de\u8d28\u67e0\u6aac\u9178\u4ea7\u751f\u4e59\u9170\u8f85\u9176A\u3002\u76f8\u53cd\uff0c\u7531STK11 \/ LKB1\u80bf\u7624\u6291\u5236\u9014\u5f84\u63a7\u5236\u7684AMP\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff08AMPK\uff09\u901a\u8fc7\u4f7fACC\u78f7\u9178\u5316\u6765\u963b\u65adFA\u5408\u6210\u3002<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u5c3d\u7ba1\u65e9\u671f\u7814\u7a76\u8bc1\u660e\u764c\u75c7\u4e2d\u80fd\u4ece\u5934\u5408\u6210FA\uff0c\u4f46\u764c\u7ec6\u80de\u8fd8\u5fc5\u987b\u4ece\u7ec6\u80de\u5916\u73af\u5883\u4e2d\u83b7\u53d6\u4e00\u4e9b\u8102\u8d28\u3002\u8102\u8d28\u6444\u53d6\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u6765\u5b9e\u73b0\uff0c\u5982Goldstein\u548cBrown\u7814\u7a76\u9610\u660e\uff0c\u53ef\u901a\u8fc7\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\uff08LDLR\uff09\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u5b9e\u73b0\u3002\u6b64\u5916\uff0cFFA\u901a\u8fc7CD36\u8102\u80aa\u9178\u8f6c\u5ea7\u9176\u6216\u8102\u80aa\u9178\u8f6c\u8fd0\u86cb\u767d\u8f93\u5165\u3002\u8102\u80aa\u9178\u7ed3\u5408\u86cb\u767d\uff08FABPs\uff09\u4e5f\u6709\u52a9\u4e8eFA\u7684\u5438\u6536\uff0cFABP\u662f\u4e00\u7c7b\u6d89\u53caFA\u5438\u6536\u548c\u8fd0\u8f93\u7684\u86cb\u767d\u8d28\u5bb6\u65cf\u3002<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u764c\u7ec6\u80de\u4ece\u5934\u5408\u6210FA\u7684\u589e\u52a0\u4f1a\u6539\u53d8\u7ec6\u80de\u8102\u8d28\u7ec4\u6210\uff0c\u8fd9\u4e00\u7279\u6027\u53ef\u7528\u4e8e\u533b\u5b66\u8bca\u65ad\u3002\u764c\u7ec6\u80de\u4ece\u5934\u5408\u6210FA\u51cf\u5c11\u4e86\u901a\u8fc7\u5916\u90e8\u6444\u53d6\u83b7\u5f97\u7684\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178\u7684\u76f8\u5bf9\u6570\u91cf\uff0c\u4f46\u589e\u52a0\u4e86\u819c\u8102\u8d28\u4e2d\u9971\u548c\u8102\u80aa\u9178\u548c\u5355\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff08MUFA\uff09\u7684\u6570\u91cf\u3002\u764c\u7ec6\u80de\u7684\u8fd9\u79cd\u7279\u5f81\u80fd\u9632\u6b62\u8102\u8d28\u8fc7\u6c27\u5316\uff0c\u800c\u8102\u8d28\u8fc7\u6c27\u5316\u662f\u7531\u5b58\u5728\u6d3b\u6027\u6c27\uff08ROS\uff09\u65f6PUFA\u7684\u8fc7\u6c27\u5316\u5f15\u8d77\u3002\u5728\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528Soraphen A\u6d88\u8017\u6216\u6291\u5236FA\u5408\u6210\u4f1a\u6539\u53d8\u819c\u52a8\u529b\u5b66\uff0c\u5e76\u4f7f\u764c\u7ec6\u80de\u66f4\u5bb9\u6613\u53d7\u5230\u6c27\u5316\u5e94\u6fc0\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002\u7136\u800c\uff0cFA\u7684\u6444\u53d6\u5bf9\u4e8e\u764c\u75c7\u4e5f\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\uff0c\u5df2\u8bc1\u660e\u6444\u53d6\u7ec6\u80de\u5916\u5305\u62ec\u68d5\u6988\u9178\u5728\u5185\u7684FA\u4f1a\u4fc3\u8fdb\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u8f6c\u79fb\u3002\u540c\u6837\uff0c\u901a\u8fc7CD36\u963b\u65adFA\u6444\u53d6\u5728\u524d\u5217\u817a\u764c\u7684\u4e34\u5e8a\u6a21\u578b\u4e2d\u5177\u6709\u6cbb\u7597\u4f5c\u7528\u3002\u4f46\u662f\uff0c\u4ece\u5934\u5408\u6210\u548c\u6444\u53d6\u7684\u76f8\u5bf9\u4f5c\u7528\u8fd8\u53d6\u51b3\u4e8e\u5bf9\u7ec6\u80de\u5916\u73af\u5883\u4e2d\u4e0d\u540c\u8102\u8d28\u79cd\u7c7b\u7684\u5229\u7528\uff0c\u8fd9\u53ef\u80fd\u4f1a\u53d7\u5230\u996e\u98df\u4e2d\u8102\u8d28\u6210\u5206\u7684\u5f71\u54cd\uff0c\u4f46\u7531\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f02\u8d28\u6027\uff0c\u4f1a\u5bf9\u5c40\u90e8\u8102\u8d28\u7684\u5229\u7528\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">3. \u80c6\u56fa\u9187\u751f\u7269\u5408\u6210<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u80c6\u56fa\u9187\u662f\u751f\u7269\u819c\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u7531\u7532\u7f9f\u620a\u9178\u9014\u5f84\u4e2d\u7684\u7c7b\u5f02\u620a\u4e8c\u70ef\u524d\u4f53\u4ea7\u751f\u3002\u7532\u7f9f\u620a\u9178\u9014\u5f84\u50ac\u5316\u4e24\u4e2a\u78b3\u5355\u5143\u4ece\u4e59\u9170\u57fa-CoA\u4f9d\u6b21\u7f29\u5408\u5f62\u62103-\u7f9f\u57fa-3-\u7532\u57fa\u620a\u4e8c\u9170\u8f85\u9176A\uff0c\u968f\u540e\u88ab\u8fd8\u539f\u6210\u7532\u7f9f\u620a\u9178\u916f\u3002\u4e4b\u540e\u53cd\u5e94\u5f62\u6210\u7c7b\u5f02\u620a\u4e8c\u70ef\u6cd5\u5c3c\u57fa\u78f7\u9178\u7126\u78f7\u9178\u916f\uff08FPP\uff09\uff0cFPP\u53ef\u7528\u4e8e\u86cb\u767d\u8d28\u5f02\u620a\u4e8c\u70ef\u5316\u548c\u6cdb\u918c\uff08\u8f85\u9176Q10\uff09\u3001\u8840\u7ea2\u7d20A\u6216\u591a\u73af\u9187\u7684\u5408\u6210\u3002<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u591a\u9879\u7814\u7a76\u8868\u660e\uff0c\u6291\u5236\u80c6\u56fa\u9187\u5408\u6210\u5bf9\u764c\u7ec6\u80de\u6709\u5bb3\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u4ed6\u6c40\u7c7b\u836f\u7269\uff08\u4e00\u79cd\u6291\u5236HMG-CoA\u8fd8\u539f\u9176\u7684\u5316\u5408\u7269\uff0c\u662f\u7532\u7f9f\u620a\u9178\u9014\u5f84\u7684\u9650\u901f\u9176\uff09\u5bf9\u80c6\u56fa\u9187\u7684\u6291\u5236\u4f5c\u7528\u5df2\u7ecf\u518d\u6297\u764c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u867d\u7136\u4e00\u4e9b\u7814\u7a76\u62a5\u544a\u7532\u7f9f\u620a\u9178\u9014\u5f84\u6291\u5236\u5242\u5728\u964d\u4f4e\u764c\u75c7\u98ce\u9669\u4e2d\u7684\u76ca\u5904\uff0c\u4f46\u5176\u4ed6\u7814\u7a76\u672a\u80fd\u8bc1\u660e\u4ed6\u6c40\u7c7b\u836f\u7269\u5728\u764c\u75c7\u9884\u9632\u6216\u8f85\u52a9\u6cbb\u7597\u65b9\u9762\u7684\u660e\u663e\u6548\u679c\u3002<\/span><span style=\"color: #000000; 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color: #333333; clear: both; box-sizing: border-box; margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word; background-color: #ffffff;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-family: \u5b8b\u4f53; font-size: 14px; line-height: 150%; padding: 0px; margin: 0px;\">\uff08B\uff09\u63a7\u5236\u8102\u80aa\u9178\u548c\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u57fa\u56e0\u8868\u8fbe\u7684\u8f6c\u5f55\u8c03\u8282\u56e0\u5b50\u662f\u56fa\u9187\u8c03\u8282\u5143\u4ef6\u7ed3\u5408\u86cb\u767d\uff08SREBP1\u548cSREBP2\uff09\uff0c\u5b83\u4eec\u4ee5\u4e8c\u805a\u4f53\u7684\u5f62\u5f0f\u4e0e\u5176\u9776\u57fa\u56e0\u542f\u52a8\u5b50\u4e2d\u56fa\u9187\u8c03\u8282\u5143\u4ef6\uff08SREs\uff09\u7ed3\u5408\u3002\u809dX\u53d7\u4f53\u03b2\uff08LXR\u03b2\uff0c\u4e5f\u79f0\u4e3a\u6838\u53d7\u4f53\u4e9a\u5bb6\u65cf1 H\u7fa4\u6210\u54582\uff0cNR1H2\uff09\u4f5c\u4e3a\u5f02\u4e8c\u805a\u4f53\u4e0e\u7c7b\u7ef4\u751f\u7d20X\u53d7\u4f53\uff08RXR\uff09\u7ed3\u5408\u6765\u4fdd\u5b58SREBF1a\u548cABCA1\u542f\u52a8\u5b50\u57fa\u56e0\u4e2dLXR\u53cd\u5e94\u5143\u4ef6\uff08LXRE\uff09\uff0c\u4ee5\u4fc3\u8fdb\u8102\u8d28\u5408\u6210\u548c\u80c6\u56fa\u9187\u8f6c\u8fd0\u3002<\/span><\/strong><\/p>\n<p style=\"text-align: center; color: #333333; clear: both; box-sizing: border-box; margin: 0px; padding: 0px; max-width: 100%; overflow-wrap: break-word; background-color: #ffffff;\"><strong style=\"padding: 0px; margin: 0px;\"><span style=\"font-family: \u5b8b\u4f53; font-size: 14px; line-height: 150%; padding: 0px; margin: 0px;\">\u00a0<\/span><\/strong><\/p>\n<p><span style=\"font-size: 16px; font-family: \u5b8b\u4f53;\">\u00a0\u00a0 <\/span><span style=\"font-size: 16px;\">\u00a0<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u80c6\u56fa\u9187\u6c34\u5e73\u8fd8\u53d7LDL\u9897\u7c92\u6444\u53d6\u548c\u901a\u8fc7\u8102\u86cb\u767d\u5206\u6ccc\u80c6\u56fa\u9187\u6765\u63a7\u5236\u3002\u4f8b\u5982\uff0c\u7814\u7a76\u8868\u660e\u809d\u810fX\u53d7\u4f53\uff08LXR\uff09\u6fc0\u52a8\u5242LXR-623\u901a\u8fc7\u8bf1\u5bfc\u80c6\u56fa\u9187\u5916\u6d41\u6765\u964d\u4f4e\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e2d\u7684\u764c\u7ec6\u80de\u5b58\u6d3b\u7387\u548c\u80bf\u7624\u751f\u957f\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px; font-family: \u5b8b\u4f53;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">4. \u8102\u80aa\u9178\u548c\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u7684\u8f6c\u5f55\u8c03\u63a7<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u8102\u80aa\u751f\u6210\u589e\u52a0\u548c\u7532\u7f9f\u620a\u9178\u9014\u5f84\u6fc0\u6d3b\u662f\u7531\u5c5e\u4e8e\u8fd9\u4e9b\u9014\u5f84\u7684\u9176\u7684\u8868\u8fbe\u589e\u5f3a\u5bfc\u81f4\uff0c\u800c\u8fd9\u4e9b\u9176\u662f\u7531\u56fa\u9187\u8c03\u8282\u5143\u4ef6\u7ed3\u5408\u86cb\u767d\uff08SREBPs\uff09\u8c03\u8282\uff08\u56fe2B\uff09\u3002SREBP\u5bb6\u65cf\u7684\u87ba\u65cb-\u73af-\u87ba\u65cb\u4eae\u6c28\u9178\u62c9\u94fe\uff08HLH-LZ\uff09\u8f6c\u5f55\u56e0\u5b50\u5bb6\u65cf\u7531\u4e09\u79cd\u4e9a\u578b\u7ec4\u6210\uff1aSREBF1\u57fa\u56e0\u7f16\u7801\u7684SREBP1a\u548cSREBP1c\uff0c\u4ee5\u53ca\u7531SREBF2\u57fa\u56e0\u7f16\u7801\u7684SREBP2\u3002SREBPs\u662f\u5b58\u5728\u4e8e\u5185\u8d28\u7f51\u819c\u4e2d\u4ee5\u8de8\u819c\u86cb\u767d\u5f62\u5f0f\u5b58\u5728\u7684\u65e0\u6d3b\u6027\u524d\u4f53\uff0c\u5e76\u4e0e\u4f34\u4fa3\u5206\u5b50SREBP\u88c2\u89e3\u6fc0\u6d3b\u86cb\u767d\uff08SCAP\uff09\u7ed3\u5408\u3002SREBPs\u6839\u636e\u7ec6\u80de\u56fa\u9187\u7684\u6d53\u5ea6\u51b3\u5b9a\u662f\u4fdd\u7559\u5728\u5185\u8d28\u7f51\u4e2d\u8fd8\u662f\u8f6c\u8fd0\u5230\u9ad8\u5c14\u57fa\u4f53\u4e2d,\u5728\u9ad8\u5c14\u57fa\u4f53\u4e2d\u901a\u8fc7\u4e24\u6b65\u86cb\u767d\u6c34\u89e3\u8fc7\u7a0b\u91ca\u653e\u51faN\u7aef\u4e00\u534a\u7684\u86cb\u767d\u8d28\uff0c\u7136\u540e\uff0c\u6210\u719f\u7684SREBPs\u6613\u4f4d\u81f3\u7ec6\u80de\u6838\uff0c\u5e76\u4ee5\u4e8c\u805a\u4f53\u7684\u5f62\u5f0f\u7ed3\u5408\u5230\u5176\u9776\u57fa\u56e0\u542f\u52a8\u5b50\u5185\u7684\u56fa\u9187\u8c03\u8282\u5143\u4ef6\uff08SRE\uff09\u548c\u589e\u5f3a\u76d2\u4e0a\u3002\u867d\u7136\u6240\u6709SREBP\u4e9a\u578b\u90fd\u53ef\u4ee5\u7ed3\u5408SRE\uff0c\u4f46\u5b83\u4eec\u5bf9\u4e0d\u540c\u7684\u542f\u52a8\u5b50\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u504f\u7231\uff0c\u5176\u4e2dSREBP1\u4e3b\u8981\u8c03\u8282\u53c2\u4e0eFA\u5408\u6210\u7684\u57fa\u56e0\uff0c\u800c\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u9014\u5f84\u7684\u57fa\u56e0\u5219\u4f18\u5148\u7531SREBP2\u63a7\u5236\u3002\u6b64\u5916\uff0c\u4e0d\u540c\u7684SREBP\u4e9a\u578b\u8868\u73b0\u51fa\u7ec4\u7ec7\u7279\u5f02\u6027\uff0c\u5176\u4e2dSREBP1c\u4e3b\u8981\u5b58\u5728\u4e8e\u809d\u810f\u4e2d\uff0c\u800cSREBP2\u4e3b\u8981\u5b58\u5728\u4e8e\u809d\u810f\u548c\u767d\u8272\u8102\u80aa\u7ec4\u7ec7\u4e2d\u3002Srebf2\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u7684\u6700\u65b0\u7814\u7a76\u8868\u660e\uff0cSREBP2\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u80a2\u4f53\u6a21\u5f0f\u4e2d\u5177\u6709\u4f5c\u7528\uff0c\u5e76\u4e14SREBP2\u5177\u6709\u8bf1\u5bfcSREBP1a\u548cSREBP1c\u8868\u8fbe\u7684\u80fd\u529b\u3002<\/span><\/section>\n<section style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u51e0\u9879\u7814\u7a76\u53d1\u73b0\uff0cSREBPs\u5728\u81f4\u764c\u4fe1\u53f7\u901a\u8def\u7684\u4e0b\u6e38PI3K \/ Akt \/ mTORC1\u4fe1\u53f7\u901a\u8def\u4e0a\u88ab\u6fc0\u6d3b\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u5b9e\u9645\u4e0a\uff0cmTORC1\u4fc3\u8fdb\u6210\u719f\u7684SREBP1\u6838\u79ef\u7d2f\uff0c\u4ece\u800c\u5728\u7ec6\u80de\u751f\u957f\u8fc7\u7a0b\u4e2d\u9a71\u52a8\u8102\u8d28\u5408\u6210\uff0c\u800cSREBP\u8bf1\u5bfc\u662fmTORC1\u9014\u5f84\u7684\u4e3b\u8981\u8f6c\u5f55\u4ea7\u7269\uff0cSREBP\u8bf1\u5bfc\u8c03\u8282\u7684\u57fa\u7840\u53ef\u80fd\u662fmTORC1\u4f7fCREB\u8c03\u8282\u7684\u8f6c\u5f55\u5171\u6fc0\u6d3b\u56e0\u5b502\uff08CRTC2\uff09\u78f7\u9178\u5316\u548c\u5931\u6d3b\uff0c\u4ece\u800c\u5bfc\u81f4SREBP \/ SCAP\u590d\u5408\u7269\u7684\u5185\u8d28\u7f51-\u9ad8\u5c14\u57fa\u4f53\u8f6c\u8fd0\u589e\u5f3a\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u6b64\u5916\uff0cmTORC1\u901a\u8fc7\u78f7\u8102\u9178\u78f7\u9178\u9176LPIN1\u7684\u78f7\u9178\u5316\u548c\u80de\u8d28\u4fdd\u7559\u6765\u8c03\u8282\u6210\u719fSREBP1\u7684\u4e9a\u6838\u5b9a\u4f4d\uff0cLPIN1\u5728\u975e\u78f7\u9178\u5316\u72b6\u6001\u4e0b\u901a\u8fc7\u5c06SREBP1\u9694\u79bb\u5728\u6838\u5916\u56f4\u6765\u6291\u5236SREBP1\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u4f46\u662f\uff0c\u4e5f\u5b58\u5728\u63a7\u5236SREBP\u548cAkt\u4e0b\u6e38\u809d\u810f\u8102\u80aa\u5f62\u6210\u7684mTORC1\u72ec\u7acb\u9014\u5f84\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u6b64\u5916\uff0c\u7814\u7a76\u8868\u660e\uff0c\u6291\u5236\u9ed1\u7d20\u7624\u4e2d\u81f4\u764c\u7684BRAF\u4f1a\u963b\u65adSREBP1\uff0c\u5e76\u4e14\u6301\u7eed\u7684\u8102\u8d28\u5408\u6210\u4e0e\u8be5\u75be\u75c5\u7684\u6cbb\u7597\u8010\u836f\u6027\u76f8\u5173\uff0c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8102\u8d28\u5408\u6210\u5728\u764c\u75c7\u4e2d\u7684\u91cd\u8981\u6027\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u8c03\u63a7\u8102\u8d28\u5408\u6210\u4e5f\u662f\u6784\u5efaMyc\u81f4\u764c\u57fa\u56e0\u76f8\u5173\u8f6c\u5f55\u56e0\u5b50\u7f51\u7edc\u7684\u5173\u952e\u6b65\u9aa4\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\"> MondoA\uff08\u4e5f\u79f0\u4e3aMLXIP\uff09\u662fMyc\u8d85\u5bb6\u65cf\u7684\u4e00\u5458\uff0c\u5b83\u901a\u8fc7SREBP1\u8c03\u8282\u8102\u80aa\u751f\u6210\uff0c\u8bc1\u660eMyc\u4f9d\u8d56\u6027\u80bf\u7624\u53d1\u751f\u662f\u5fc5\u9700\u7684\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u6b64\u5916\uff0c\u7814\u7a76\u8868\u660eMyc\u4e0eSREBP1\u534f\u540c\u4f5c\u7528\u5728\u591a\u79cd\u764c\u75c7\u6a21\u578b\u7684\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u9a71\u52a8\u8102\u80aa\u751f\u6210\u3002<\/span><\/section>\n<p style=\"margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; text-align: left; text-indent: 2em; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u5982\u4e0a\u6240\u8ff0\uff0cSREBP\u7684\u52a0\u5de5\u53d7\u7ec6\u80de\u56fa\u9187\u6d53\u5ea6\u63a7\u5236\uff0c\u6e38\u79bb\u80c6\u56fa\u9187\u6c34\u5e73\u7684\u53d8\u5316\u53ef\u6539\u53d8SREBP\u6d3b\u6027\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0cp53\u8bf1\u5bfcATP\u7ed3\u5408\u76d2\u8f6c\u8fd0\u86cb\u767d\uff08ABCA1\uff09\u589e\u52a0\u4e86\u80c6\u56fa\u9187\u4ece\u8d28\u819c\u5411\u5185\u8d28\u7f51\u7684\u9006\u884c\u8f6c\u8fd0\uff0c\u4ece\u800c\u963b\u6b62SREBP2\u6210\u719f\u3002\u4f46\u662f\uff0c\u7531\u4e8eABCA1\u4ecb\u5bfc\u80c6\u56fa\u9187\u5916\u6392\uff0c\u5e76\u4e14\u81ea\u8eab\u53d7SREBP2\u57fa\u56e0\u5185\u542b\u5b50\u7f16\u7801\u7684microRNA\u63a7\u5236\uff0c\u4f7f\u5f97\u8fd9\u4e00\u60c5\u51b5\u66f4\u52a0\u590d\u6742\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u56fa\u9187O-\u9170\u57fa\u8f6c\u79fb\u91761\uff08SOAT1\uff0c\u4e5f\u79f0\u4e3aACAT1\uff09\u8c03\u8282\u80c6\u56fa\u9187\u916f\u5316\u548c\u50a8\u5b58\uff0c\u53ef\u63a7\u5236SREBP\u7684\u6d3b\u6027\u548c\u63a7\u5236\u524d\u5217\u817a\u764c\u7ec6\u80de\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u764c\u7ec6\u80de\u5b58\u6d3b\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px;\">\u00a0 \u00a0 \u00a0\u00a0<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u901a\u8fc7\u8c03\u8282F-Box\u548cWD\u91cd\u590d\u7ed3\u6784\u57df\u86cb\u767d7\uff08FBXW7\uff09\u7684\u6cdb\u7d20\u4f9d\u8d56\u6027\uff0c\u53ef\u4ee5\u4e25\u683c\u63a7\u5236\u6210\u719fSREBP\u7684\u7a33\u5b9a\u6027\u3002\u6240\u6709SREBP\u4e9a\u578b\u90fd\u5305\u542b\u4e00\u4e2a\u80fd\u88abFBXW7 \/ SCF\u590d\u5408\u4f53\u8bc6\u522b\u7684\u4fdd\u5b88\u7684\u78f7\u9178\u8131\u6c22\u57fa\u5e8f\uff08CPD\uff09\u3002\u5728SREBPs\u4e2d\uff0c\u7cd6\u539f\u5408\u9176\u6fc0\u91763\uff08GSK3\uff09\u5bf9\u8be5\u57fa\u5e8f\u7684\u78f7\u9178\u5316\u8bf1\u5bfc\u4e86\u5176\u6cdb\u7d20\u5316\u548c\u964d\u89e3\uff0cAKT\u6216mTORC2\u590d\u5408\u7269\u5bf9GSK3\u7684\u6291\u5236\u4f5c\u7528\u5bfc\u81f4\u6210\u719f\u7684SREBP\u66f4\u52a0\u7a33\u5b9a\u3002\u6b64\u5916\uff0c\u7cbe\u6c28\u9178\u7532\u57fa\u8f6c\u79fb\u91765\uff08PRMT5\uff09\u5bf9\u7cbe\u6c28\u9178\u7684\u4e8c\u7532\u57fa\u5316\u53ef\u9632\u6b62SREBP1a\u88abGSK-3beta\u78f7\u9178\u5316\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u9664SREBP\u5916\uff0c\u809dX\u53d7\u4f53\u3001LXR-\u03b1\u548cLXR-\u03b2\uff08\u56fe2B\uff09\u540c\u6837\u662f\u764c\u75c7\u4e2d\u8102\u80aa\u751f\u6210\u7684\u91cd\u8981\u9a71\u52a8\u529b\u3002\u8fd9\u4e9b\u6838\u53d7\u4f53\u4e0e\u7c7b\u7ef4\u751f\u7d20X\u53d7\u4f53\uff08LXR\uff09\u5f62\u6210\u5f02\u6e90\u4e8c\u805a\u4f53\uff0c\u5f02\u6e90\u4e8c\u805a\u4f53\u5728\u4e0d\u540c\u7684\u6c27\u56fa\u9187\u5b58\u5728\u4e0b\u8bf1\u5bfc\u57fa\u56e0\u8868\u8fbe\uff0c\u5176\u4e2d\u6c27\u56fa\u9187\u8d77LXR\u914d\u4f53\u7684\u4f5c\u7528\u3002LXR\u662f\u764c\u75c7\u6cbb\u7597\u7684\u9776\u6807\uff0c\u4f46\u53d1\u73b0LXR\u7684\u6fc0\u6d3b\u548c\u6291\u5236\u5728\u4e0d\u540c\u60c5\u51b5\u4e0b\u90fd\u4e0d\u5229\u4e8e\u764c\u7ec6\u80de\u7684\u751f\u957f\u3002\u7531\u4e8eSREBP1c\u662fLXR\u9776\u57fa\u56e0\u4e4b\u4e00\uff0c\u4f7f\u7528\u53cd\u5411\u6fc0\u52a8\u5242SR9243\u6291\u5236LXR\uff0c\u53d1\u73b0\u662f\u901a\u8fc7\u6291\u5236\u7cd6\u9175\u89e3\u548c\u8102\u80aa\u751f\u6210\u6765\u963b\u6b62\u764c\u7ec6\u80de\u7684\u751f\u957f\u3002\u8fd9\u5bfc\u81f4\u591a\u7cfb\u7edf\u80bf\u7624\u751f\u957f\u51cf\u5c11\uff0c LXR\u6291\u5236\u6210\u4e3a\u4e00\u79cd\u6709\u5438\u5f15\u529b\u7684\u6297\u80bf\u7624\u7b56\u7565\u3002\u76f8\u53cd\uff0c\u5982\u524d\u6240\u8ff0\uff0c\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e2d\u4e0d\u540c\u6fc0\u52a8\u5242\u6fc0\u6d3bLXR\u4e5f\u88ab\u8bc1\u660e\u901a\u8fc7\u4fc3\u8fdb\u80c6\u56fa\u9187\u7684\u8f93\u51fa\u800c\u964d\u4f4e\u764c\u7ec6\u80de\u5b58\u6d3b\u7387\u3002\u8102\u6e90\u6027\u8f6c\u5f55\u56e0\u5b50\u4e0e\u81f4\u764c\u4fe1\u53f7\u7f51\u7edc\u7684\u591a\u79cd\u8054\u7cfb\u673a\u5236\u6e05\u695a\u5730\u8868\u660e\u5b83\u4eec\u5bf9\u4e8e\u764c\u7ec6\u80de\u751f\u957f\u548c\u5b58\u6d3b\u7684\u91cd\u8981\u6027\u3002<\/span><\/p>\n<p style=\"text-indent: 32px;\"><span style=\"font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">5. \u63a8\u52a8\u764c\u75c7\u8868\u578b<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u8102\u8d28\u4fc3\u6210\u8bb8\u591a\u5728\u764c\u75c7\u4e2d\u88ab\u89e3\u9664\u9650\u5236\u7684\u8fc7\u7a0b\u3002\u591a\u9879\u7814\u7a76\u5df2\u7ecf\u63a2\u8ba8\u4e86\u8102\u8d28\u751f\u7269\u5408\u6210\u6291\u5236\u4f5c\u7528\u5bf9\u764c\u7ec6\u80de\u5b58\u6d3b\u548c\u80bf\u7624\u751f\u957f\u7684\u5f71\u54cd\u3002\u9488\u5bf9FASN\u7684\u5316\u5408\u7269\u5df2\u7ecf\u5728\u4e0d\u540c\u7684\u764c\u75c7\u6a21\u578b\u4e2d\u5f00\u53d1\u548c\u6d4b\u8bd5\u3002\u6b64\u5916\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684Kras \/ p53-\/-\u548cKras \/ Stk11-\/-\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u4f7f\u7528\u522b\u6784\u6291\u5236\u5242ND-646\u6291\u5236ACC1\u548cACC2\u65e2\u53ef\u4f5c\u4e3a\u5355\u4e00\u836f\u7269\u4e5f\u53ef\u8054\u5408\u4f7f\u7528\uff0c\u51cf\u7f13\u80bf\u7624\u7684\u751f\u957f\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u8102\u8d28\u9664\u4e86\u5177\u6709\u4f5c\u4e3a\u7ec6\u80de\u819c\u6210\u5206\u7684\u7ed3\u6784\u529f\u80fd\u5916\uff0c\u8fd8\u80fd\u4f5c\u4e3a\u80bf\u7624\u751f\u957f\u7684\u4ecb\u8d28\u53d1\u6325\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u9798\u8102\u662f\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u548c\u751f\u5b58\u7684\u4e3b\u8981\u4ecb\u8d28\u3002\u5728\u4ee5\u4e0b\u5404\u8282\u4e2d\uff0c\u6211\u4eec\u5c06\u4e3b\u8981\u5173\u6ce8FA\u5728\u80fd\u91cf\u4ee3\u8c22\uff0c\u5e94\u6fc0\u53cd\u5e94\u548c\u764c\u75c7\u7ec6\u80de\u5b58\u6d3b\u4e2d\u7684\u4f5c\u7528\u3002\u6211\u4eec\u8fd8\u5c06\u8ba8\u8bba\u6709\u5173\u8102\u8d28\u91cd\u5851\u4e0e\u80a5\u5927\u75c7\u3001\u764c\u7ec6\u80de\u8f6c\u79fb\u3001\u5e72\u7ec6\u80de\u548c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u5f02\u8d28\u6027\u4e4b\u95f4\u7684\u8054\u7cfb\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">6. \u80fd\u91cf\u4ee3\u8c22\u4e2d\u7684\u8102\u8d28<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">FA\u5408\u6210\u7684\u91cd\u65b0\u6fc0\u6d3b\u662f\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff0cFAO\u5bf9\u4e8e\u5404\u79cd\u764c\u75c7\u7684\u764c\u7ec6\u80de\u5b58\u6d3b\u81f3\u5173\u91cd\u8981\u3002\u5728\u8bb8\u591a\u6076\u6027\u80bf\u7624\u4e2d\u53d1\u73b0\u4e86FAO\u9176\u7684\u8fc7\u5ea6\u8868\u8fbe\uff0c\u800c\u5728\u4e00\u4e9b\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u5bf9FAO\u7684\u963b\u65ad\u4f1a\u51cf\u5f31\u80bf\u7624\u7684\u751f\u957f\u901f\u5ea6\u3002\u5728\u539f\u4f4d\u60a3\u8005\u884d\u751f\u7684\u5f02\u79cd\u79fb\u690d\uff08PDX\uff09\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u6a21\u578b\u548c\u539f\u4f4d\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6a21\u578b\u4e2d\uff0c\u6291\u5236FAO\u7684\u9650\u901f\u9176\u8089\u78b1\u68d5\u6988\u9170\u8f6c\u79fb\u91761\uff08CPT1\uff09\u7684\u8868\u8fbe\u53ef\u5ef6\u7f13\u80bf\u7624\u751f\u957f\u5e76\u5ef6\u957f\u751f\u5b58\u671f\u3002CPT1\u4e0a\u6e38\u7684\u9176\u5bf9\u4e8e\u80bf\u7624\u751f\u957f\u81f3\u5173\u91cd\u8981\uff0c\u5982\u9170\u57fa\u8f85\u9176A\u5408\u6210\u9176\u957f\u94fe3\uff08ACSL3\uff09\u5c06FFA\u8f6c\u5316\u4e3a\u8102\u80aa\u9170\u57fa\u8f85\u9176A\uff0c\u53ef\u7528\u4f5c\u8102\u8d28\u5408\u6210\u7684\u5e95\u7269\uff08\u56fe1\uff09\u6216FAO\u3002KrasG12D-\u9a71\u52a8\u80ba\u764c\u8fc7\u8868\u8fbeACSL3\uff0c\u964d\u4f4e\u4e86FA\u6444\u53d6\u91cf\uff0cFAO\u4ea7\u751f\u91cf\u548c\u80bf\u7624\u8d1f\u8377\u3002\u540c\u6837\uff0c\u5728\u4eba\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e2d\uff0c\u4e0e\u4e2d\u94fe\u548c\u957f\u94fe\u8102\u80aa\u9170\u57fa\u8f85\u9176A\u7ed3\u5408\u7684\u9170\u57fa\u8f85\u9176A\u7ed3\u5408\u86cb\u767d\uff08ACBP\uff09\u6210\u4e3a\u8102\u80aa\u9170\u57fa\u8f85\u9176A\u7684\u8f7d\u4f53\u6216\u652f\u67b6\uff0cACBP\u7684\u6d88\u8017\u6291\u5236\u4e86FAO\uff0c\u5bfc\u81f4\u539f\u4f4d\u5f02\u79cd\u79fb\u690d\u548c\u9057\u4f20\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5c0f\u9f20\u6a21\u578b\u7684\u8870\u8001\u3002\u5728\u67d0\u4e9b\u764c\u75c7\u4e2d\uff0cFAO\u88ab\u7279\u5b9a\u7684\u764c\u57fa\u56e0\u6fc0\u6d3b\u6765\u652f\u6301\u7ec6\u80de\u589e\u6b96\uff0c\u4f8b\u5982TNBC\u4e2d\u7684c-Myc\u6216\u80ba\u764c\u4e2d\u7684\u7a81\u53d8Kras\u3002FAO\u5728\u80fd\u91cf\u7d27\u5f20\u671f\u95f4\u4f1a\u63d0\u4f9bNADPH\uff0c\u4f8b\u5982\u5f53\u8461\u8404\u7cd6\u7f3a\u4e4f\u6216\u620a\u7cd6\u78f7\u9178\u9014\u5f84\uff08PPP\uff09\u4ea7\u751f\u7684NADPH\u53d7\u5230\u635f\u5bb3\u65f6\u4f1a\u4e3a\u673a\u4f53\u63d0\u4f9bNADPH\u3002\u4ece\u673a\u7406\u4e0a\u8bb2\uff0c\u8fd9\u4f9d\u8d56\u4e8eAMPK\uff0cAMPK\u4f7fACC\u78f7\u9178\u5316\u5e76\u4f7f\u4e4b\u5931\u6d3b\uff0c\u4ece\u800c\u963b\u65adFA\u7684\u5408\u6210\uff0cFA\u7684\u5408\u6210\u662f\u80de\u8d28NADPH\u7684\u4e3b\u8981\u6d88\u8017\u8005\uff0c\u800c\u4e14FA\u5408\u6210\u8fd8\u53ef\u4ee5\u6fc0\u6d3bFAO\u4f5c\u4e3a\u4e19\u4e8c\u9170\u8f85\u9176A\uff1bACC\u7684\u4ea7\u7269\u662fCPT1\u7684\u53d8\u6784\u6291\u5236\u5242\u3002FAO\u884d\u751f\u7684\u4e59\u9170\u8f85\u9176A\u662f\u5982\u4f55\u88ab\u7528\u6765\u751f\u6210\u80de\u8d28NADPH\u7684\u5c1a\u4e0d\u6e05\u695a,\u76ee\u524d\u5df2\u77e5\u7684\u662f\u5b83\u4ee5\u67e0\u6aac\u9178\u76d0\u7684\u5f62\u5f0f\u8f93\u51fa\u5230\u7ec6\u80de\u8d28\u4e2d\uff0c\u7136\u540e\u88ab\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u91761\uff08IDH1\uff09\u6c27\u5316\u6210\u03b1-\u916e\u620a\u4e8c\u9178\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">7. \u5e94\u6fc0\u53cd\u5e94\u548c\u7ec6\u80de\u5b58\u6d3b<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">FAs\u4e0d\u4ec5\u662fATP\u548cNADPH\u7684\u6765\u6e90\uff0c\u8fd8\u662f\u7ec6\u80de\u4e2d\u91cd\u8981\u7684\u7ed3\u6784\u6210\u5206\u3002\u7ec6\u80de\u4e2d\u6700\u4e30\u5bcc\u7684FA\u4e4b\u4e00\u662fMUFA\u6cb9\u9178\uff08C18\uff1a1\uff09\u3002\u5728\u4ece\u5934\u5408\u6210FA\u7684\u8fc7\u7a0b\u4e2d\uff0cSCD\u50ac\u5316\u786c\u8102\u9178\uff08C18\uff1a0\uff09\u4e2d\u7684\u03949\u4f4d\u5f62\u6210\u53cc\u952e\uff0c\u5e76\u5728\u8f83\u5c0f\u7a0b\u5ea6\u4e0a\u50ac\u5316\u68d5\u6988\u9178\uff08C16\uff1a0\uff09\u5206\u522b\u5f62\u6210\u6cb9\u9178\u548c\u68d5\u6988\u6cb9\u9178\uff08C16\uff1a1\uff09\uff08\u56fe1\uff09\u3002\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u6291\u5236\u8fd9\u79cd\u53cd\u5e94\u4f1a\u5bfc\u81f4\u5728\u8102\u8d28\u8017\u5c3d\u6761\u4ef6\u4e0b\u4f53\u5916\u57f9\u517b\u7684\u764c\u7ec6\u80de\u4e2d\u4ea7\u751f\u5185\u8d28\u7f51\u5e94\u6fc0\u548c\u51cb\u4ea1\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6dfb\u52a0\u5916\u6e90\u6cb9\u9178\u6216\u5176\u4ed6\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff0c\u4f8b\u5982PUFA\u4e9a\u6cb9\u9178\uff08C18\uff1a2\uff09\u6216\u82b1\u751f\u56db\u70ef\u9178\uff08C20\uff1a4\uff09\uff0c\u9632\u6b62\u901a\u8fc7SCD\u6291\u5236\u5bfc\u81f4\u7684\u5185\u8d28\u7f51\u5e94\u6fc0\u548c\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5728\u80c3\u764c\u548c\u7ed3\u80a0\u764c\u7684\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u4f7f\u7528SCD\u6291\u5236\u5242\u6cbb\u7597\u53ef\u51cf\u5c11\u80bf\u7624\u5f62\u6210\uff0c\u5e76\u4e14SCD\u8017\u635f\u80fd\u963b\u6b62\u4eba\u4f53\u5185\u80ba\u764c\u7ec6\u80de\u7684\u80bf\u7624\u751f\u957f\u3002SCD\u6c89\u9ed8\u964d\u4f4e\u4e86\u4eba\u7c7b\u524d\u5217\u817a\u764c\u7ec6\u80de\u5f62\u6210\u539f\u4f4d\u5f02\u79cd\u79fb\u690d\u80bf\u7624\u7684\u80fd\u529b\uff0c\u8868\u660e\u8be5\u5668\u5b98\u4e2d\u5b58\u5728\u7684\u5916\u6e90\u6027\u8102\u8d28\u65e0\u6cd5\u8865\u507fSCD\u529f\u80fd\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u8fd9\u4e9b\u7ed3\u679c\u8bc1\u660eSCD\u5bf9\u80bf\u7624\u751f\u957f\u7684\u91cd\u8981\u6027\uff0c\u4f46\u8102\u80aa\u9971\u548c\u5ea6\u5bfc\u81f4\u5185\u8d28\u7f51\u5e94\u6fc0\u548c\u7ec6\u80de\u51cb\u4ea1\u673a\u7406\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u5df2\u7ecf\u77e5\u9053\u7684\u662f\uff0c\u542b\u6709\u9971\u548c\u8102\u80aa\u9178\u7684\u8102\u8d28\u79ef\u7d2f\u4f1a\u5bfc\u81f4\u8102\u80aa\u6bd2\u6027\u548c\u5185\u8d28\u7f51\u5e94\u6fc0\uff0c\u800c\u542b\u6709\u4e0d\u9971\u548c\u8102\u80aa\u9178\u7684\u8102\u8d28\u53ef\u4ee5\u9006\u8f6c\u8fd9\u4e9b\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u6709\u4eba\u63d0\u51fa\u6539\u53d8\u5185\u8d28\u7f51\u819c\u4e2d\u9971\u548c\u548c\u4e0d\u9971\u548cFA\u7684\u6bd4\u4f8b\uff0c\u4ee5\u589e\u52a0\u9971\u548c\u5ea6\u53c2\u4e0e\u672a\u6298\u53e0\u86cb\u767d\u8d28\u53cd\u5e94\uff08UPR\uff09\u7684\u673a\u4f1a\u3002\u4f46\u662f\uff0c\u6291\u5236\u53bb\u9971\u548c\u4f1a\u635f\u5bb3\u7ebf\u7c92\u4f53\u547c\u5438\u4ece\u800c\u5bfc\u81f4\u6c27\u5316\u5e94\u6fc0\uff0c\u8868\u660e\u5185\u8d28\u7f51\u5e94\u6fc0\u8bf1\u5bfc\u53ef\u80fd\u662f\u95f4\u63a5\u5f15\u8d77\u7684\u3002\u9664\u6cb9\u9178\u5916\uff0c\u6297\u6c27\u5316\u5242\u8fd8\u53ef\u4ee5\u963b\u6b62SCD\u8017\u5c3d\u540e\u8bf1\u5bfc\u7684\u5185\u8d28\u7f51\u5e94\u6fc0\u3002\u5728\u524d\u5217\u817a\u764c\u7ec6\u80de\u4e2d\u663e\u793a\u6291\u5236SCD\u53ef\u51cf\u5c11MUFA\u4e0e\u5fc3\u78f7\u8102\u7684\u7ed3\u5408\uff0c\u5fc3\u78f7\u8102\u662f\u4e00\u79cd\u4ec5\u5b58\u5728\u4e8e\u7ebf\u7c92\u4f53\u5185\u819c\u7684\u7279\u6b8a\u8102\u8d28\u3002\u5728\u6866\u6728\u9178\u53cd\u5e94\u4e2d\u5fc3\u78f7\u8102\u5408\u6210\u4e5f\u6709\u7c7b\u4f3c\u7684\u964d\u4f4e\uff0c\u6866\u6728\u9178\u662f\u4e00\u79cd\u690d\u7269\u6027\u5316\u5408\u7269\uff0c\u53ef\u4ee5\u901a\u8fc7\u6291\u5236SCD\u6765\u963b\u6b62\u764c\u7ec6\u80de\u751f\u957f\u3002\u5fc3\u78f7\u8102\u4e0e\u7ec6\u80de\u8272\u7d20c\u7ed3\u5408\u5e76\u963b\u6b62\u5176\u4ece\u7ebf\u7c92\u4f53\u5185\u819c\u91ca\u653e\uff0c\u4ece\u800c\u63a7\u5236\u5185\u5728\u7684\u7ec6\u80de\u51cb\u4ea1\u9014\u5f84\u3002\u5728\u4e24\u9879\u7814\u7a76\u4e2d\uff0cSCD\u6291\u5236\u4e0e\u7ec6\u80de\u8272\u7d20C\u91ca\u653e\u589e\u52a0\u662f\u540c\u65f6\u53d1\u751f\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">S<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">CD\u6291\u5236\u6216\u6d88\u8017\u4ec5\u5728\u7ec6\u80de\u4e0d\u80fd\u5438\u6536\u5916\u6e90\u6027\u8102\u8d28\u65f6\u624d\u53d1\u6325\u4f5c\u7528\uff0c\u8fd9\u8868\u660e\u7ec6\u80de\u5916\u8102\u8d28\u5145\u8db3\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u764c\u7ec6\u80de\u901a\u8fc7\u6444\u53d6\u6765\u6ee1\u8db3\u5bf9\u4e0d\u9971\u548c\u8102\u80aa\u9178\u7684\u9700\u6c42\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u6b64\u5916\uff0cSCD\u9700\u8981NADPH\u548c\u6c27\u6c14\u53d1\u6325\u529f\u80fd\uff0c\u8fd9\u8868\u660e\u5728\u4f4e\u6c27\u6761\u4ef6\u4e0b\uff0c\u764c\u7ec6\u80de\u4f9d\u8d56\u4e8e\u5916\u6e90\u6027\u4e0d\u9971\u548c\u8102\u80aa\u9178\u7684\u4f9b\u5e94\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">SCD\u7684\u8868\u8fbe\u662f\u7531\u7f3a\u6c27\u5f15\u8d77\u7684\uff0c\u8fd9\u53ef\u80fd\u662f\u4e3a\u4e86\u5f25\u8865\u8fd9\u79cd\u6761\u4ef6\u4e0b\u50ac\u5316\u6d3b\u6027\u7684\u964d\u4f4e\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u6b64\u5916\uff0c\u5728\u6c27\u6c14\u548c\u8102\u8d28\u7f3a\u4e4f\u7684\u6761\u4ef6\u4e0b\u7ef4\u6301SCD\u8868\u8fbe\u4ee5\u4f7fFA\u53bb\u9971\u548c\u662fSREBP1\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7ec6\u80de\u4e2d\u7684\u91cd\u8981\u529f\u80fd\u3002<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px; text-indent: 2em; line-height: 1.6;\">\u764c\u7ec6\u80de\u5229\u7528\u5916\u6e90\u8102\u8d28\u63d0\u4f9b\u4e0d\u9971\u548c\u8102\u80aa\u9178\u7684\u80fd\u529b\u53d6\u51b3\u4e8e\u81f4\u764c\u57fa\u56e0\u8868\u8fbe\u7684\u7c7b\u578b\uff0c\u5e76\u4e14\u5e76\u975e\u6240\u6709\u8102\u8d28\u90fd\u5f97\u5230\u540c\u7b49\u5229\u7528\u3002<\/span><span style=\"color: #000000; 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text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">SCD\u4f5c\u4e3aMUFA\u7684\u63d0\u4f9b\u8005\uff0c\u4f46\u5728\u8102\u8d28\u7f3a\u4e4f\u7684\u60c5\u51b5\u4e0b\u764c\u7ec6\u80de\u7684\u4e9a\u7fa4\u663e\u793a\u51fa\u5bf9SCD\u6291\u5236\u4e0d\u654f\u611f\u3002\u7814\u7a76\u8868\u660e\uff0c\u5f53SCD\u88ab\u6291\u5236\u65f6\uff0c\u8fd9\u4e9b\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7FA\u53bb\u9971\u548c\u91762\uff08FADS2\uff09\u6765\u6ee1\u8db3\u5bf9\u4e0d\u9971\u548cFAs\u7684\u9700\u6c42\u3002FADS2\u901a\u5e38\u662fPUFA\u4e9a\u6cb9\u9178\uff08\u03c9-6\uff09\u548c\u03b1-\u4e9a\u6cb9\u9178\uff08\u03c9-3\uff09\u8f6c\u5316\u4e3a\u5176\u4ed6PUFA\u7684\u5fc5\u8981\u7269\u8d28\u3002\u4f46\u662f\uff0cFADS2\u4e5f\u53ef\u4ee5\u4f7f\u68d5\u6988\u9178\u53bb\u9971\u548c\u751f\u6210\u03946\u4f4d\u5305\u542b\u53cc\u952e\u7684FA sapienate\uff0c\u8fd9\u8ddfSCD\u5408\u6210\u68d5\u6988\u9178\u5728\u03949\u4f4d\u751f\u6210\u53cc\u952e\u7684\u60c5\u51b5\u76f8\u53cd\u3002\u5f53\u68d5\u6988\u9178\u6c34\u5e73\u8f83\u9ad8\u65f6\uff0c\u5373SCD\u88ab\u6291\u5236\u6216\u4e0d\u8868\u8fbe\u65f6\uff08\u5982\u5728\u4eba\u76ae\u8102\u817a\u4e2d\uff09\uff0cSapienate\u7684\u4ea7\u751f\u4f1a\u88ab\u66ff\u4ee3\uff0c\u5728\u8fd9\u4e9b\u6761\u4ef6\u4e0b\uff0c\u68d5\u6988\u9178\u4f1a\u4e0eFADS2\uff0c\u4e9a\u6cb9\u9178\u548c\u03b1-\u4e9a\u9ebb\u9178\u7b49\u5929\u7136\u5e95\u7269\u7ade\u4e89\u3002\u5f53SCD\u88ab\u963b\u65ad\u65f6\uff0c\u5bf9SCD\u6291\u5236\u4e0d\u654f\u611f\u7684\u764c\u7ec6\u80de\u4f1a\u4ea7\u751fsapienate\uff0c\u8fd9\u662f\u7531\u4e8eFADS2\u8017\u5c3d\u4f7f\u8fd9\u4e9b\u7ec6\u80de\u5bf9SCD\u6291\u5236\u654f\u611f\u3002\u540c\u6837\uff0cFADS2\u5f02\u4f4d\u8868\u8fbe\u4e8e\u5bf9SCD\u6291\u5236\u654f\u611f\u7684\u7ec6\u80de\u4e2d\u4e5f\u4f1a\u8bf1\u5bfc\u5bf9SCD\u6291\u5236\u7684\u6297\u6027\u3002\u4e0e\u5065\u5eb7\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u4eba\u7c7b\u809d\u764c\u548c\u80ba\u764c\u4e2d\u7684sapienate\u542b\u91cf\u548cFADS2\u8868\u8fbe\u5747\u5347\u9ad8\uff0c\u5728\u5c0f\u9f20\u809d\u7ec6\u80de\u764c\u6a21\u578b\u4e2d\uff0cFADS2\u548cSCD\u7684\u8054\u5408\u6291\u5236\u5bfc\u81f4\u5c0f\u9f20\u809d\u7ec6\u80de\u764c\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u751f\u957f\u51cf\u5c11\uff0c\u8bc1\u5b9e\u4e86\u81f3\u5c11\u6709\u4e9b\u764c\u75c7\u4f7f\u7528\u8fd9\u79cd\u66ff\u4ee3\u9014\u5f84\u8fdb\u884cFA\u53bb\u9971\u548c\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u9664FA\u5408\u6210\u548c\u6444\u53d6\u5916\uff0c\u819c\u78f7\u8102\u4e2d\u9971\u548c\u548c\u4e0d\u9971\u548cFA\u7684\u76f8\u5bf9\u4e30\u5ea6\u4e5f\u53d7\u6eb6\u8840\u78f7\u8102\u9170\u57fa\u8f6c\u79fb\u9176\uff08LPLAT\uff09\u7684\u8c03\u8282\u3002LPLAT\u4e0e\u78f7\u8102\u9176A2\uff08PLA2\uff09\u5728\u4e00\u7cfb\u5217\u7684\u53bb\u9170\u5316\u548c\u518d\u9170\u5316\u6b65\u9aa4\uff08\u79f0\u4e3aLands\u5faa\u73af\uff09\u4e2d\u91cd\u5851\u7ec6\u80de\u78f7\u8102\uff08\u56fe1\uff09\u3002\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0cPLA2\u6c34\u89e3\u7518\u6cb9\u78f7\u8102\u5728sn-2\u4f4d\u7f6e\u7684\u9170\u57fa\u94fe\u751f\u62101-\u9170\u57fa-\u6eb6\u8840\u78f7\u8102\uff0c\u7136\u540e\u901a\u8fc7LPLATs\u8fdb\u884c\u518d\u9170\u5316\u3002\u7531\u4e8e\u4e0d\u540c\u7684LPLAT\u9176\u5bf9FA\u5e95\u7269\u548c\u6eb6\u8840\u78f7\u8102\u9776\u6807\u7684\u504f\u597d\u4e0d\u540c\uff0c\u56e0\u6b64\u8be5\u8fc7\u7a0b\u4f1a\u4ea7\u751f\u591a\u79cd\u78f7\u8102\u79cd\u7c7b\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u4e00\u79cdLPLAT\u4e9a\u578b&#8211;\u6eb6\u8840\u78f7\u8102\u9170\u80c6\u78b1\u9170\u57fa\u8f6c\u79fb\u91763\uff08LPCAT3\uff0c\u4e5f\u79f0\u4e3aMBOAT5\uff09\uff0c\u5728SCD\u6291\u5236\u5f15\u8d77\u7684\u5185\u8d28\u7f51\u5e94\u6fc0\u8fc7\u7a0b\u4e2d\uff0c\u5bf9\u8c03\u8282\u78f7\u8102\u4e2d\u4e0d\u9971\u548c\u8102\u80aa\u9178\u4e0e\u9971\u548c\u8102\u80aa\u9178\u4e4b\u95f4\u7684\u6bd4\u4f8b\u5177\u6709\u91cd\u8981\u7684\u4f5c\u7528\u3002\u764c\u7ec6\u80de\u4e2dSCD\u7684\u7f3a\u5931\u5f15\u8d77LPCAT3\u7684\u4e0a\u8c03\uff0c\u4f46\u672a\u5f15\u8d77\u5176\u4ed6LPCAT\u4e9a\u578b\u7684\u4e0a\u8c03\u3002\u6b64\u5916\uff0c\u867d\u7136LPCAT3\u8017\u5c3d\u672c\u8eab\u5e76\u4e0d\u4f1a\u5bfc\u81f4\u5185\u8d28\u7f51\u5e94\u6fc0\uff0c\u4f46\u5728SCD1\u8017\u5c3d\u6216\u68d5\u6988\u9178\u66b4\u9732\u540e\u4f1a\u52a0\u5267\u5185\u8d28\u7f51\u5e94\u6fc0\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">LPCAT3\u7684\u4e3b\u8981\u5e95\u7269\u662fPUFAs\uff0cLPCAT3\u7684\u6d88\u8017\u51cf\u5c11\u4e86PUFAs\u4e0e\u78f7\u8102\u9170\u80c6\u78b1\uff08PC\uff09\u7684\u7ed3\u5408\uff0c\u751f\u6210\u66f4\u591a\u7684\u9971\u548c\u819c\u8102\u8d28\u3002\u5728\u809d\u7ec6\u80de\u4e2d\u53d1\u73b0LXR\u4e0b\u6e38\u7684LPCAT3\u8868\u8fbe\u589e\u52a0\u5bf9\u4e8eSREBP1\u6210\u719f\u548c\u6838\u79fb\u4f4d\u81f3\u5173\u91cd\u8981\u3002LPCAT3\u7684\u7f3a\u5931\u964d\u4f4e\u4e86PC\u4e2dPUFA\u7684\u6bd4\u4f8b\uff08\u4e3b\u8981\u662f\u82b1\u751f\u56db\u70ef\u9178\u548c\u4e9a\u6cb9\u9178\uff09\uff0c\u5e76\u4e25\u91cd\u635f\u5bb3\u4e86SREBP1\u7684\u6210\u719f\u5ea6\u3002\u56e0\u6b64 SREBP1\u7684\u52a0\u5de5\u5bf9\u819c\u8102\u8d28\u7684\u53bb\u9971\u548c\u975e\u5e38\u654f\u611f\u3002\u867d\u7136\u5c1a\u4e0d\u80fd\u786e\u5b9a\u542bPUFA\u7684PC\u4fc3\u8fdbSREBP1\u6210\u719f\u7684\u786e\u5207\u673a\u5236\uff0c\u4f46\u53d1\u73b0\u8be5\u8fc7\u7a0b\u662fSCAP\u4f9d\u8d56\u6027\u7684\uff0c\u8fd9\u8868\u660e\u819c\u8102\u8d28\u53bb\u9971\u548c\u53ef\u4ee5\u8c03\u8282ER\u819c\u52a8\u529b\u5b66\u6765\u4fc3\u8fdbSCAP \/ SREBP\u76f8\u4e92\u4f5c\u7528\u6216ER\u5411SREBP\u7684\u9ad8\u5c14\u57fa\u4f53\u79fb\u4f4d\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\">\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">8. \u8102\u8d28\u4ee3\u8c22\u4e0e\u7ec6\u80de\u94c1\u6b7b\u4ea1<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; 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text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u9176ACSL3\u548cACSL4\u53ef\u4ee5\u8c03\u8282\u78f7\u8102\u7684FA\u7ec4\u6210\u548c\u5bf9\u94c1\u6b7b\u4ea1\u7684\u654f\u611f\u6027\u3002\u5b83\u4eec\u6fc0\u6d3bFAs\u4ee5\u8fdb\u5165\u8102\u8d28\uff08\u56fe1\uff09\uff0c\u800c\u4e0d\u540c\u7684ACSLs\u5177\u6709\u4e0d\u540c\u7684\u5e95\u7269\u504f\u597d\u3002ACSL4\u5bf9PUFA\u5177\u6709\u5f3a\u70c8\u7684\u504f\u597d\u6027\uff0c\u5e76\u4e14\u5728\u4e73\u817a\u764c\u7ec6\u80de\u7cfb\u4e2d\u6291\u5236\u8c37\u80f1\u7518\u80bd\u8fc7\u6c27\u5316\u7269\u91764\uff08GPX4\uff09\u540e\u5176\u8868\u8fbe\u4e0e\u94c1\u6b7b\u4ea1\u654f\u611f\u6027\u76f8\u5173\u3002GPX4\u7528\u4e8e\u53bb\u9664\u819c\u8102\u4e2d\u7684\u8102\u8d28\u8fc7\u6c27\u5316\u7269\uff0c\u5bf9GPX4\u7684\u6291\u5236\u6216\u6d88\u8017\u53ef\u5f15\u8d77\u94c1\u6b7b\u4ea1\u3002\u5c3d\u7ba1ACSL4-\/-\u7ec6\u80de\u5bf9GPX4\u6291\u5236\u6709\u6297\u6027\uff0c\u4f46\u5728\u5916\u6e90PUFA\u5b58\u5728\u4e0b\u57f9\u517b\u65f6\uff0c\u5b83\u4eec\u53ef\u4ee5\u518d\u81f4\u654f\u5316\u3002\u8fd9\u53ef\u80fd\u662f\u7531ACSL3\u9020\u6210\u7684\uff0c\u56e0\u4e3a\u53ea\u6709ACSL3\u548cACSL4\u6709\u6548\u5730\u5229\u7528PUFA\u4f5c\u4e3a\u5e95\u7269\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u5916\u6e90\u6027MUFA\u901a\u8fc7\u4ece\u819c\u78f7\u8102\u4e2d\u7f6e\u6362PUFA\u6765\u9884\u9632\u94c1\u6b7b\u4ea1\u3002\u8fd9\u53d6\u51b3\u4e8eACSL3\uff0c\u56e0\u4e3aACSL3\u7684\u6d88\u8017\u4f1a\u6d88\u9664\u7531MUFA\u8bf1\u5bfc\u7684\u6297\u94c1\u6b7b\u4ea1\u3002ACSL4\u66f4\u559c\u6b22PUFA\u4f5c\u4e3a\u5e95\u7269\uff0c\u800cACSL3\u53ef\u4ee5\u6fc0\u6d3b\u8fd9\u4e24\u79cd\u7c7b\u578b\u7684FA\uff0c\u56e0\u6b64\uff0c\u5728ACSL3\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u7ec6\u80de\u78f7\u8102\u7684FA\u7ec4\u6210\u53ef\u4ee5\u53cd\u6620\u51fa\u6444\u53d6\u548c\u4ece\u5934\u5408\u6210\u83b7\u5f97\u7684MUFA \/ PUFA\u6bd4\u503c\u3002\u5728\u6ca1\u6709ACSL3\u7684\u60c5\u51b5\u4e0b\uff0c\u7531\u4e8eACSL4\u6210\u4e3aFA\u6fc0\u6d3b\u7684\u4e3b\u8981\u9176\uff0c\u56e0\u6b64\u8be5\u6bd4\u4f8b\u504f\u5411PUFA\u3002\u867d\u7136\u5916\u6e90\u6027MUFA\u4ecb\u5bfc\u7684\u94c1\u6b7b\u4ea1\u4fdd\u62a4\u4f5c\u7528\u662fACSL3\u4f9d\u8d56\u6027\u7684\uff0c\u4f46\u5bf9\u4e8e\u8102\u80aa\u6bd2\u6027\u5374\u4e0d\u662f\uff0c\u5728\u6ca1\u6709ACLS3\u7684\u60c5\u51b5\u4e0b\uff0c\u6cb9\u9178\u53ef\u9632\u6b62\u5916\u6e90\u6027\u68d5\u6988\u9178\u5f15\u8d77\u7684\u7ec6\u80de\u51cb\u4ea1\u3002\u8fd9\u8868\u660e\uff0c\u867d\u7136\u9700\u8981ACSL3\u7528MUFA\u4ee3\u66ffPUFA\u4ece\u800c\u964d\u4f4e\u94c1\u6b7b\u4ea1\u7684\u654f\u611f\u6027\uff0c\u4f46\u5176\u4ed6\u9176\u53ef\u4ee5\u5c06MUFA\u5f15\u5165\u78f7\u8102\u4e2d\u4ece\u800c\u964d\u4f4e\u603b\u9971\u548c\u5ea6\uff0c\u4e14\u4e0d\u4f1a\u5f71\u54cdPUFA\u78f7\u8102\u7684\u91cf\u3002FA\u53bb\u9971\u548c\u4e0e\u7ec6\u80de\u5e94\u6fc0\u53cd\u5e94\u9014\u5f84\u548c\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u7684\u63a7\u5236\u9519\u7efc\u590d\u6742\u5730\u8054\u7cfb\u5728\u4e00\u8d77\uff0c\u56e0\u6b64\uff0c\u7ef4\u6301\u7a33\u5b9a\u7684FA\u53bb\u9971\u548c\u72b6\u6001\u5bf9\u4e8e\u764c\u7ec6\u80de\u5b58\u6d3b\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">9. \u764c\u7ec6\u80de\u6269\u6563\u548c\u8f6c\u79fb<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u764c\u7ec6\u80de\u8f6c\u79fb\u662f\u4e00\u4e2a\u590d\u6742\u7684\u8fc7\u7a0b\uff0c\u6d89\u53ca\u764c\u7ec6\u80de\u4ece\u539f\u53d1\u80bf\u7624\u5411\u8840\u6db2\u6216\u6dcb\u5df4\u7cfb\u7edf\u7684\u6269\u6563\u3001\u5411\u5176\u4ed6\u5668\u5b98\u7684\u8f6c\u79fb\u4ee5\u53ca\u7ee7\u53d1\u6027\u80bf\u7624\u5728\u5176\u4ed6\u90e8\u4f4d\u7684\u6269\u6563\u3002\u5c3d\u7ba1\u8f6c\u79fb\u662f\u9020\u6210\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u4f46\u5176\u673a\u5236\u4ecd\u662f\u672a\u89e3\u4e4b\u8c1c\u3002\u7136\u800c\uff0c\u6700\u65b0\u53d1\u73b0\u8868\u660e\u8102\u8d28\u4ee3\u8c22\u5728\u8f6c\u79fb\u4e2d\u8d77\u4e3b\u8981\u4f5c\u7528\u3002\u4f8b\u5982\uff0c FASN\u6291\u5236\u4f5c\u7528\u963b\u6b62\u4e86\u5728\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u505c\u836f\u540e\u7684\u8f6c\u79fb\u5f62\u6210\uff0c\u4f46\u8fd9\u4e00\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002SREBP1\u901a\u8fc7\u5411E-\u9499\u7c98\u86cb\u767d\u542f\u52a8\u5b50\u52df\u96c6SNAIL \/ HDAC1 \/ 2\u963b\u904f\u590d\u5408\u7269\u6765\u9a71\u52a8\u4e73\u817a\u764c\u4e2d\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\u7684\u8f6c\u5f55\u7a0b\u5e8f\u3002\u7136\u800c\uff0cSREBP1\u7684\u8fd9\u79cd\u529f\u80fd\u662f\u901a\u8fc7\u5176\u76f4\u63a5\u7ed3\u5408E-\u9499\u7c98\u86cb\u767d\u542f\u52a8\u5b50\u800c\u4e0d\u662f\u901a\u8fc7\u5bf9FA\u5408\u6210\u7684\u8c03\u8282\u6765\u5b9e\u73b0\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0cFAs\u76f4\u63a5\u5730\u53c2\u4e0e\u4e86\u8f6c\u79fb\uff0c\u5982\u4fb5\u88ad\u6027\u764c\u7ec6\u80de\u7cfb\uff0c\u5373\u90a3\u4e9b\u5177\u6709\u8f83\u9ad8\u8fc1\u79fb\u80fd\u529b\u548c\u80bf\u7624\u751f\u957f\u80fd\u529b\u7684\u764c\u7ec6\u80de\u7cfb\uff0c\u5b83\u80fd\u9ad8\u6c34\u5e73\u8868\u8fbe\u5355\u9170\u57fa\u7518\u6cb9\u8102\u80aa\u9176\uff08MAGL\uff09\uff0c\u5728\u8102\u6c34\u89e3\u8fc7\u7a0b\u4e2d\u4ece\u5355\u9170\u57fa\u7518\u6cb9\u4e2d\u91ca\u653eFFA\u3002MAGL\u7684\u8868\u8fbe\u8bf1\u5bfc\u4e86\u4e00\u79cd\u80fd\u9884\u793a\u6076\u6027\u75be\u75c5\u53d1\u751f\u7684\u7279\u5f02\u6027\u8102\u8d28\u4fe1\u53f7\uff0c\u5728\u7f3a\u4e4f\u8fd9\u79cd\u4fe1\u53f7\u7684\u60c5\u51b5\u4e0b\uff0c\u53ef\u901a\u8fc7\u9ad8\u8102\u996e\u98df\uff08HFD\uff09\u6062\u590d\u80bf\u7624\u7684\u751f\u957f\uff0c\u8868\u660e\u5916\u6e90\u6027FA\u53ef\u4ee5\u4fc3\u8fdb\u75be\u75c5\u7814\u7a76\u8fdb\u5c55\u3002\u540c\u6837\uff0c\u7531\u4e8eSOAT1\u7684\u80c6\u56fa\u9187\u916f\u5f62\u6210\u589e\u52a0\uff0cPTEN-\/-\u524d\u5217\u817a\u764c\u4e2d\u7684\u8f6c\u79fb\u589e\u52a0\u4e0eLDLR\u7684\u6301\u7eed\u8868\u8fbe\u53ca\u5fc5\u9700\u7684FA\u6444\u53d6\u589e\u52a0\u6709\u5173\u3002\u901a\u8fc7FA\u8f6c\u8fd0\u86cb\u767dCD36\u6444\u53d6FFA\u7684\u91cf\u589e\u52a0\u53ef\u4fc3\u8fdb\u809d\u7ec6\u80de\u764c\u7684EMT\uff0c\u8fd9\u4e3b\u8981\u5f52\u56e0\u4e8e\u68d5\u6988\u9178\u916f\u548c\u6cb9\u9178\u916f\u7684\u6444\u53d6\u800c\u4e0d\u662f\u5fc5\u9700\u7684FAs\u3002\u6e90\u81ea\u9cde\u72b6\u7ec6\u80de\u764c\uff08\u4e00\u79cd\u9ad8\u5ea6\u4fb5\u88ad\u6027\u53e3\u8154\u764c\uff09\u7684\u8f6c\u79fb\u8d77\u59cb\u7ec6\u80de\uff08MIC\uff09\u80fd\u9ad8\u6c34\u5e73\u8868\u8fbeCD36\u548c\u8102\u8d28\u4ee3\u8c22\u4fe1\u53f7\u57fa\u56e0\uff0cCD36\u7684\u6291\u5236\u6216\u8017\u7aed\u5bf9\u539f\u53d1\u6027\u80bf\u7624\u7684\u751f\u957f\u5f71\u54cd\u4e0d\u5927\uff0c\u4f46\u8f6c\u79fb\u5374\u5927\u5927\u51cf\u5c11\uff0c\u8fd9\u8868\u660eFA\u7684\u5438\u6536\u548c\u4ee3\u8c22\u4fc3\u8fdb\u4e86\u764c\u7ec6\u80de\u7684\u6269\u6563\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u5c06\u5c0f\u9f20\u66b4\u9732\u4e8e\u68d5\u6988\u9178\u6216\u5c06\u5b83\u4eec\u7f6e\u4e8eHFD\u4e0a\uff0c\u53ef\u4ee5\u4ee5CD36\u4f9d\u8d56\u6027\u65b9\u5f0f\u589e\u5f3a\u8f6c\u79fb\u3002\u5c3d\u7ba1\u5728\u8be5\u7cfb\u7edf\u4e2d\u5c1a\u672a\u5b8c\u5168\u89e3\u51b3\u5916\u6e90FA\u7684\u786e\u5207\u4f5c\u7528\uff0c\u4f46\u6709\u8bc1\u636e\u8868\u660e\uff0cMICs\u4f7f\u7528FA\u6765\u901a\u8fc7FAO\u53d1\u7535\u3002\u7528\u6297CD36\u4e2d\u548c\u6297\u4f53\u6cbb\u7597\u5c0f\u9f20\u53e3\u8154\u539f\u4f4d\u80bf\u7624\uff0c\u53ef\u4ee5\u6d88\u9664\u8f6c\u79fb\u7684\u5f62\u6210\uff0c\u4e3a\u764c\u75c7\u6cbb\u7597\u63d0\u51fa\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u7b56\u7565\u3002\u7c7b\u4f3c\u5730\uff0c\u53d1\u73b0\u6fc0\u6d3bSREBP\u4f9d\u8d56\u7684\u8102\u80aa\u751f\u6210\u7a0b\u5e8f\u53ef\u4ee5\u9a71\u52a8PTEN\u548cPML\u7f3a\u5931\u7684\u524d\u5217\u817a\u764c\u7684\u8f6c\u79fb\u3002\u5e76\u4e14HFD\u8db3\u4ee5\u9a71\u52a8\u975e\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u6a21\u578b\u4e2d\u7684\u8f6c\u79fb\u5f62\u6210\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\u5916\u6e90\u6027FA\u4e0e\u764c\u75c7\u7814\u7a76\u8fdb\u5c55\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u9664FAs\u5916\uff0c\u7532\u7f9f\u620a\u9178\u9014\u5f84\u4e5f\u4e0e\u7ec4\u7ec7\u7ed3\u6784\u7684\u4e27\u5931\u548c\u764c\u75c7\u7684\u8fdb\u5c55\u6709\u5173\u3002\u7a81\u53d8\u578bp53\u901a\u5e38\u5728\u4fb5\u88ad\u6027\u764c\u75c7\u4e2d\u53d1\u73b0\uff0c\u5b83\u80fd\u7ed3\u5408SREBP2\u5e76\u6fc0\u6d3b\u4e73\u817a\u764c\u7ec6\u80de\u4e2d\u7532\u7f9f\u620a\u9178\u9014\u5f84\u7684\u9176\u8868\u8fbe\u3002\u7532\u7f9f\u620a\u9178\u9014\u5f84\u6fc0\u6d3b\u5bfc\u81f4FPP\u7684\u5f62\u6210\uff0cFPP\u662f\u5c0fG\u86cb\u767d\uff08\u5305\u62ecRas\u548cRhoA\uff09\u7684\u5f02\u620a\u4e8c\u70ef\u5316\u6240\u5fc5\u9700\u7684\u3002\u56e0\u6b64\uff0c\u4ee3\u8c22\u9014\u5f84\u7684\u6fc0\u6d3b\u53ef\u4ee5\u9a71\u52a8\u764c\u7ec6\u80de\u8fc1\u79fb\u548c\u4fb5\u88ad\u6240\u5fc5\u9700\u7684\u4fe1\u53f7\u4f20\u5bfc\u7a0b\u5e8f\u3002\u76ee\u524d\u5df2\u7ecf\u7814\u7a76\u4e86\u7528\u4e8e\u6cbb\u7597\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u7684\u7532\u7f9f\u620a\u9178\u9014\u5f84\u6291\u5236\u5242\u4f5c\u4e3a\u6297\u764c\u836f\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u4e34\u5e8a\u6570\u636e\u9664\u4e86\u8868\u660e\u8102\u8d28\u5728\u764c\u7ec6\u80de\u8f6c\u79fb\u4e2d\u4f5c\u7528\u7684\uff0c\u8fd8\u663e\u793a\u51fa\u8f6c\u79fb\u6027\u764c\u7ec6\u80de\u5728\u8102\u8d28\u4ee3\u8c22\u4e2d\u53d1\u751f\u7684\u6539\u53d8\u3002\u764c\u7ec6\u80de\u4ece\u79f0\u4e3a\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff08CTC\uff09\u7684\u539f\u53d1\u6027\u80bf\u7624\u90e8\u4f4d\u5411\u8840\u6db2\u4e2d\u4f20\u64ad\u662f\u8f6c\u79fb\u6027\u80bf\u7624\u6240\u8868\u73b0\u51fa\u7684\u7279\u6027\u3002\u4f7f\u7528\u65e0\u6807\u8bb0\u76f8\u5e72\u6297\u7126\u6591\u62c9\u66fc\u6563\u5c04\u663e\u5fae\u955c\u5bf9\u524d\u5217\u817a\u764c\u60a3\u8005\u8fdb\u884c\u7684\u4e00\u9879\u7814\u7a76\u663e\u793a\uff0cCTC\u4e2d\u8102\u8d28\u6444\u5165\u91cf\u9ad8\uff0c\u7ec6\u80de\u5185\u8102\u8d28\u79ef\u7d2f\u4e5f\u589e\u52a0\u3002\u4e00\u9879\u4e13\u95e8\u9488\u5bf9\u4fb5\u88ad\u6027\u80bf\u7624\u60a3\u8005\u7684\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff08TCGA\uff09\u6cdb\u764c\u6570\u636e\u7684\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u663e\u793a\uff0c\u4e0eFA\u6444\u53d6\u548c\u4ece\u5934\u8102\u8d28\u5408\u6210\u76f8\u5173\u7684\u57fa\u56e0\u7684\u6269\u589e\u9891\u7387\u66f4\u9ad8\u3002\u53c2\u4e0eFA\u5408\u6210\u3001\u6444\u53d6\u548c\u4ee3\u8c22\u6709\u5173\u7684\u57fa\u56e0\u7684\u8868\u8fbe\u7279\u5f81\u4e5f\u4e0eEMT\u6570\u636e\u76f8\u5173\u8054\uff0c\u4ee5\u8bc6\u522b\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u4e4b\u95f4\u5e38\u89c1\u7684\u4e0e\u8f6c\u79fb\u76f8\u5173\u7684\u4ee3\u8c22\u7a0b\u5e8f\u3002\u867d\u7136\u8fd9\u4e9b\u7814\u7a76\u7a81\u51fa\u4e86\u8102\u8d28\u5728\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u4f46\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u4ee5\u63cf\u8ff0FA\u5408\u6210\u5728\u764c\u7ec6\u80de\u8f6c\u79fb\u4e2d\u7684\u786e\u5207\u4f5c\u7528\uff0c\u5e76\u8bc4\u4f30\u8102\u8d28\u4ee3\u8c22\u5728\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u786e\u5207\u4f5c\u7528\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">10. \u80bf\u7624\u5e72\u7ec6\u80de\u7684\u8102\u8d28\u4ee3\u8c22<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u80bf\u7624\u5e72\u7ec6\u80de\uff08CSCs\uff09\u6216\u80bf\u7624\u8d77\u59cb\u7ec6\u80de\uff08TICs\uff09\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u4e9a\u7fa4\uff0c\u662f\u4e0d\u540c\u4e8e\u5f02\u8d28\u6027\u80bf\u7624\u7684\u5176\u4ed6\u7ec6\u80de\u7fa4\u3002CSCs\u5177\u6709\u5f88\u9ad8\u7684\u81ea\u6211\u66f4\u65b0\u80fd\u529b\uff0c\u662f\u80bf\u7624\u53d1\u751f\u3001\u8010\u836f\u6cbb\u7597\u548c\u590d\u53d1\u7684\u672c\u8d28\u539f\u56e0\uff0c\u6240\u4ee5\u627e\u5230\u9488\u5bf9CSC\u7684\u6cbb\u7597\u7b56\u7565\u5907\u53d7\u91cd\u89c6\u3002\u4e0e\u975eCSC\u76f8\u6bd4\uff0cCSC\u8868\u73b0\u51fa\u72ec\u7279\u7684\u4ee3\u8c22\u7279\u5f81\uff0c\u5176\u4e2d\u4e4b\u4e00\u662f\u8102\u8d28\u4ee3\u8c22\u6539\u53d8\uff0c\u8fd9\u4e3a\u9274\u5b9a\u8be5\u7ec6\u80de\u7fa4\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">FASN\u8868\u8fbe\u6c34\u5e73\u7684\u63d0\u9ad8\u548cFA\u5408\u6210\u7684\u589e\u52a0\u4e0e\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e2d\u5e72\u7ec6\u80de\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u76f8\u5173\uff0c\u5e76\u4e14FASN\u6d3b\u6027\u7684\u964d\u4f4e\u53ef\u4ecb\u5bfc\u767d\u85dc\u82a6\u9187\u5bf9\u4e73\u817a\u764cCSC\u751f\u957f\u7684\u6291\u5236\u4f5c\u7528\u3002\u5728\u7b5b\u9009\u6d88\u9664\u4eba\u7c7b\u591a\u529f\u80fd\u5e72\u7ec6\u80de\u7684\u5316\u5408\u7269\u7684\u7b5b\u9009\u4e2d\u9274\u5b9a\u51faFA\u53bb\u9971\u548c\u6291\u5236\u5242\uff0c\u5e76\u4e14SCD\u6291\u5236\u4f5c\u7528\u53ef\u8bf1\u5bfc\u5185\u8d28\u7f51\u5e94\u6fc0\uff0c\u6709\u6548\u9632\u6b62\u80bf\u7624\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624CSC\u4e2d\u7684\u751f\u957f\u3002\u795e\u7ecf\u80f6\u8d28\u7624\u5e72\u7ec6\u80de\u8d85\u7ea7\u589e\u5f3a\u5b50\u53ef\u9a71\u52a8ELOVL2\u7684\u8868\u8fbe\uff0c\u4ee5\u4fc3\u8fdb\u542bPUFA\u7684\u819c\u8102\u8d28\u7684\u5408\u6210\u3001\u589e\u52a0\u819c\u6d41\u52a8\u6027\u548c\u589e\u5f3a\u4e0a\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u7684\u6d3b\u6027\u3002\u5728\u5375\u5de2\u764cCSCs\u4e2d\uff0c\u4f7f\u7528\u62c9\u66fc\u5149\u8c31\u6cd5\u53d1\u73b0\u4e0d\u9971\u548c\u8102\u80aa\u9178\u4e0e\u9971\u548c\u8102\u80aa\u9178\u7684\u6bd4\u4f8b\u589e\u52a0\u3002\u8fd9\u662f\u56e0\u4e3a\u03949\u53bb\u9971\u548c\u4f7f SCD\u7684\u6291\u5236\u964d\u4f4e\u4e86\u5375\u5de2\u764c\u7ec6\u80de\u5728\u4f53\u5185\u5f62\u6210\u7403\u4f53\u548c\u5f62\u6210\u80bf\u7624\u7684\u80fd\u529b\u3002\u589e\u5f3a\u7684FA\u53bb\u9971\u548c\u5ea6\u8fd8\u4e0e\u6d89\u53caNF-kB\u9014\u5f84\u7684\u6b63\u53cd\u9988\u56de\u8def\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u9a71\u52a8\u5375\u5de2\u764c\u4e2d\u5e72\u7ec6\u80de\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">FA\u53bb\u9971\u548c\u5bf9\u5e72\u7ec6\u80de\u529f\u80fd\u7684\u5f71\u54cd\u673a\u5236\u53ef\u80fd\u901a\u8fc7\u5bf9Wnt \/\u03b2-catenin\u4fe1\u53f7\u901a\u8def\u7684\u63a7\u5236\u3002Wnt \/\u03b2-catenin\u4fe1\u53f7\u901a\u8def\u7684\u6d3b\u6027\u53d6\u51b3\u4e8e\u8c6a\u732aO-\u9170\u57fa\u8f6c\u79fb\u9176\uff08PORCN\uff09\u5bf9Wnt\u86cb\u767d\u7684\u7ffb\u8bd1\u540e\u9170\u5316\u4f5c\u7528\uff0cPORCN\u5c06\u9170\u57fa\u94fe\u8f6c\u79fb\u5230Wnt\u86cb\u767d\u7684\u4fdd\u5b88\u534a\u80f1\u6c28\u9178\u548c\u4e1d\u6c28\u9178\u6b8b\u57fa\u4e0a\u3002Wnt\u9170\u5316\u5bf9\u5176\u4e9a\u7ec6\u80de\u5b9a\u4f4d\u53ca\u5176\u5206\u6ccc\u5230\u7ec6\u80de\u5916\u7a7a\u95f4\u975e\u5e38\u91cd\u8981\uff0c\u901a\u8fc7\u5229\u7528\u6807\u8bb0\u548c\u8d28\u8c31\u6cd5\u53d1\u73b0Wnt-3a\u4e2d\u4e1d\u6c28\u9178209\u5904\u7684\u9170\u57fa\u5e26\u6709MUFA\u68d5\u6988\u6cb9\u9178\uff0cPORCN\u4f7f\u7528\u5355\u4e0d\u9971\u548c\u9170\u57fa\u8f85\u9176A\u4f5c\u4e3aWnt\u9170\u5316\u7684\u5e95\u7269\uff0cMUFA\u7684\u5f2f\u66f2\u6784\u8c61\u53ef\u80fd\u6709\u52a9\u4e8e\u5355\u4e0d\u9971\u548c\u9170\u57fa\u8f85\u9176A\u63d2\u5165\u5377\u66f2\u53d7\u4f53\u7684\u758f\u6c34\u69fd\u4e2d\u3002\u56e0\u6b64\uff0c\u68d5\u6988\u6cb9\u9178\u916f\u7684\u6709\u6548\u6027\u53ef\u4ee5\u786e\u5b9aWnt\u9014\u5f84\u7684\u6d3b\u6027\uff0c\u5e76\u901a\u8fc7\u03b2-catenin\u7a33\u5b9a\u8c03\u8282\u5176\u4e0b\u6e38\u4fe1\u53f7\u4f20\u5bfc\u3002\u7136\u800c\uff0c\u4e0d\u9971\u548c\u8102\u80aa\u9178\u4e5f\u53ef\u4ee5\u901a\u8fc7\u6d89\u53caFAS\u76f8\u5173\u56e0\u5b501\uff08FAF1\uff09\u7684\u7b2c\u4e8c\u79cd\u673a\u5236\u8c03\u8282\u03b2-catenin\uff0c\u8be5\u56e0\u5b50\u4e0e\u03b2-catenin\u7ed3\u5408\u52a0\u901f\u5176\u964d\u89e3\uff0cFAF1\u4e0e\u4e0d\u9971\u548cFA\u7ed3\u5408\u4f1a\u7834\u574f\u5176\u4e0e\u03b2-catenin\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u4f7fFAF1\u7a33\u5b9a\u5e76\u9a71\u52a8ccRCC\u589e\u6b96\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u9664FA\u4e4b\u5916\uff0c\u78f7\u8102\u91cd\u5851\u4e5f\u5728CSC\u529f\u80fd\u4e2d\u8d77\u4f5c\u7528\uff0c\u800c\u5728\u80a0\u5e72\u7ec6\u80de\uff08ISCs\uff09\u4e2dLPCAT3\u7684\u7f3a\u5931\u4f1a\u5bfc\u81f4\u6210\u719f\u6838SREBP2\u7684\u589e\u52a0\u548c\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u9176\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u800c\u53c2\u4e0eFA\u7684SREBP1\u9776\u70b9\u7684\u8868\u8fbe\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4e0d\u53d7\u5f71\u54cd\u3002\u5728APC\u5c0f\u9f20\u4e2d\uff0cLPCAT3\u7f3a\u5931\u5bfc\u81f4ISC\u8fc7\u5ea6\u589e\u6b96\uff0c\u80bf\u7624\u5f62\u6210\u589e\u5f3a\u5e76\u964d\u4f4e\u4e86\u5b58\u6d3b\u7387\u3002\u8fd9\u4e00\u9014\u5f84\u53ef\u4ee5\u901a\u8fc7\u4ed6\u6c40\u7c7b\u836f\u7269\u6216\u7f8a\u6bdb\u753e\u9187\u5408\u9176\uff08LSS\uff09\u6291\u5236\u6765\u963b\u65ad\uff0c\u5e76\u901a\u8fc7\u8fc7\u8868\u8fbe\u6210\u719fSREBP2\u6765\u663e\u578b\u5316\uff0c\u8868\u660e\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u589e\u5f3a\u662fLPCAT3\u7f3a\u5931\u5f15\u8d77\u7684\u80a0\u9053\u80bf\u7624\u5f62\u6210\u7684\u539f\u56e0\u3002\u6b64\u5916\uff0c\u7532\u7f9f\u620a\u9178\u9014\u5f84\u57fa\u56e0\u53c2\u4e0e\u4e86MYC\u8bf1\u5bfc\u7684\u8111\u80bf\u7624\u8d77\u59cb\u7ec6\u80de\u7684\u81ea\u6211\u66f4\u65b0\u548c\u81f4\u7624\u6027\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660eFA\u548c\u80c6\u56fa\u9187\u7684\u5408\u6210\u662fCSC\u8868\u578b\u7684\u91cd\u8981\u9a71\u52a8\u529b\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px;\">\u00a0<\/span><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">11. \u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5f02\u578b\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/strong><\/p>\n<p style=\"margin: 0px; padding: 0px; color: #333333; clear: both; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; background-color: #ffffff;\"><strong><span style=\"margin: 0px; padding: 0px; color: #021eaa; font-size: 16px;\">\u00a0<\/span><\/strong><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u8102\u8d28\u9664\u4e86\u8c03\u8282\u7ec6\u80de\u7684\u5185\u5728\u8fc7\u7a0b\u5916\uff0c\u8fd8\u53c2\u4e0e\u7ec6\u80de\u95f4\u7684\u901a\u8baf\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5f02\u578b\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u662f\u764c\u75c7\u53d1\u5c55\u7684\u91cd\u8981\u9a71\u52a8\u529b\u3002\u6d89\u53ca\u8102\u8d28\u7684\u5f02\u578b\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u8303\u56f4\u53ef\u4ee5\u4ece\u5438\u5f15\u6216\u6392\u65a5\u4e0d\u540c\u57fa\u8d28\u7ec6\u80de\u7c7b\u578b\u7684\u4fe1\u53f7\u4f20\u9012\u5230\u590d\u6742\u7684\u4ee3\u8c22\u5076\u8054\u56de\u8def\uff0c\u4e3a\u764c\u7ec6\u80de\u63d0\u4f9b\u989d\u5916\u7684\u71c3\u6599\u6765\u6e90\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u8102\u8d28\u4fe1\u53f7\u6216\u8102\u8d28\u4ecb\u8d28\u7684\u4ea7\u751f\u548c\u91ca\u653e\u53d7\u5230\u8102\u8d28\u4fee\u9970\u9176\u7684\u4e25\u683c\u63a7\u5236\u3002\u5176\u4e2d\u5305\u62ecPLA2\u4e9a\u578b\uff0c\u5b83\u53ef\u5728sn-2\u4f4d\u7f6e\u88c2\u89e3\u819c\u78f7\u8102\u4ee5\u91ca\u653e\u6e38\u79bb\u7684PUFA\uff08\u56fe1\uff09\u3002\u4e00\u4e9b\u78f7\u8102\u9176\u662f\u5206\u6ccc\u86cb\u767d\uff0c\u8868\u660e\u764c\u7ec6\u80de\u79ef\u6781\u5730\u4fee\u9970\u80bf\u7624\u5fae\u73af\u5883\u8102\u8d28\u4f53\u3002\u8fd9\u4e9b\u5206\u6ccc\u7684\u78f7\u8102\u9176\u4ea7\u751f\u7684\u6eb6\u8840\u78f7\u8102\u53ef\u4ee5\u901a\u8fc7\u7ec6\u80de\u5916ATX\/ENPP2\u8fdb\u4e00\u6b65\u8f6c\u5316\u4e3a\u4fe1\u53f7\u5206\u5b50LPA\uff0c\u4ea7\u751f\u4fc3\u8fdb\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u6269\u6563\u7684\u8d8b\u5316\u68af\u5ea6\u3002\u6700\u8fd1\u53d1\u73b0\u80f0\u817a\u661f\u72b6\u7ec6\u80de\u91ca\u653e\u6eb6\u8840\u78f7\u8102\uff0c\u6eb6\u8840\u78f7\u8102\u88abATX \/ ENPP2\u8f6c\u5316\u4e3aLPA\u5e76\u4fc3\u8fdb\u80f0\u817a\u764c\u7684\u53d1\u751f\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u867d\u7136\u8102\u8d28\u4fee\u9970\u9176\uff08\u4f8b\u5982PLA2\u548cATX \/ ENPP2\uff09\u63a7\u5236\u67d0\u4e9b\u8102\u8d28\u4ecb\u8d28\u7684\u4ea7\u751f\uff0c\u4f46\u764c\u7ec6\u80de\u4e2dFA\u5408\u6210\u548c\u6444\u53d6\u7684\u6539\u53d8\u53ef\u80fd\u6709\u52a9\u4e8e\u5f62\u6210\u7279\u5b9a\u7c7b\u522b\u7684\u4fe1\u53f7\u8102\u8d28\uff0c\u5982\u901a\u8fc7\u66f4\u6539\u5177\u6709\u7279\u5b9a\u94fe\u957f\u548c\u9971\u548c\u5ea6\u7684FA\u6765\u5b9e\u73b0\u5b83\u7684\u53ef\u7528\u6027\u3002\u7814\u7a76\u8868\u660e\uff0c\u764c\u7ec6\u80de\u4f7f\u7528\u5916\u6e90\u6027\u68d5\u6988\u9178\u916f\u4e0d\u4ec5\u53ef\u4ee5\u4ea7\u751f\u7ed3\u6784\u6027\u8102\u8d28\uff0c\u8fd8\u9009\u62e9\u6027\u5730\u5c06\u8be5FA\u6574\u5408\u5230LPA\u5206\u5b50\u4e2d\u3002\u7ed3\u6784\u7814\u7a76\u8868\u660e\uff0c\u5355\u4e2aLPA\u53d7\u4f53\u5bf9\u5e26\u6709\u7279\u5b9a\u9170\u57fa\u94fe\u7684LPA\u5206\u5b50\u5177\u6709\u4e0d\u540c\u7684\u504f\u597d\uff0c\u6539\u53d8\u7684FA\u5408\u6210\u548c\u4fee\u9970\u4e5f\u53ef\u4ee5\u5851\u9020\u764c\u7ec6\u80de\u7684\u8102\u8d28\u5206\u6ccc\u4f53\uff0c\u4ece\u800c\u901a\u8fc7\u8102\u8d28\u4ecb\u8d28\u4fc3\u8fdb\u81ea\u5206\u6ccc\u548c\u65c1\u5206\u6ccc\u4fe1\u53f7\u4f20\u5bfc\u3002<\/span><\/p>\n<section style=\"text-align: left; text-indent: 2em;\"><span style=\"font-size: 16px;\">\u00a0<\/span><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u5728\u78f7\u8102\u964d\u89e3\u4e3a\u6eb6\u8840\u78f7\u8102\u7684\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u80de\u8d28\u548c\u5206\u6ccc\u7684PLA2\u4e9a\u578b\u91ca\u653e\u51fa\u5148\u524d\u7ed3\u5408\u5728sn-2\u4f4d\u7f6e\u7684\u9170\u57fa\uff0c\u6210\u4e3aFFAs\uff08\u56fe1\uff09\u3002\u8fd9\u4f7f\u5f97\u4e00\u5927\u7c7b\u4e3b\u8981\u53c2\u4e0e\u708e\u75c7\u8c03\u8282\u7684\u8102\u8d28\u4ecb\u8d28\u7684\u5408\u6210\u6210\u4e3a\u53ef\u80fd\u3002\u5176\u4e2d\u4e4b\u4e00\u7684PGE2\u662f\u7531\u82b1\u751f\u56db\u70ef\u9178\u901a\u8fc7\u73af\u6c27\u5408\u9176\uff08PTGS1 \/ COX1\u548cPTGS2 \/ COX2\uff09\u751f\u4ea7\u7684\uff0c\u5f53PGE2\u5206\u6ccc\u65f6\uff0c\u80fd\u4fc3\u8fdb\u764c\u7ec6\u80de\u589e\u6b96\u3001\u8fc1\u79fb\u548c\u8840\u7ba1\u751f\u6210\u7684\u591a\u79cd\u4fe1\u53f7\u7684\u4f20\u5bfc\u3002\u6700\u8fd1\u8bc1\u660e\u4e86COX2\u4ea7\u751f\u7684PGE2\u901a\u8fc7\u8bf1\u5bfc\u9ad3\u7cfb\u7ec6\u80de\u4ea7\u751fIL-6\uff0cCXCL1\u548cG-CSF\u4ece\u800c\u4fc3\u8fdb\u5f62\u6210\u80bf\u7624\u5fae\u73af\u5883\uff0c\u540c\u65f6\u963b\u65ad\u4e86I\u578b\u5e72\u6270\u7d20\u7684\u4ea7\u751f\uff0c\u963b\u6b62\u4e86T\u7ec6\u80de\u4f9d\u8d56\u6027\u80bf\u7624\u7684\u6d88\u9664\u3002<\/span><\/section>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u82b1\u751f\u56db\u70ef\u9178\u662f\u7531ELOVL2\u548cELOVL5\u4ee5\u53ca\u03945\u548c\u03946\u53bb\u9971\u548c\u9176FADS1\u548cFADS2\u5916\u6e90\u4e9a\u6cb9\u9178\u4ea7\u751f\u7684\uff0c\u56e0\u6b64\u8fd9\u4e9b\u9176\u7684\u8868\u8fbe\u589e\u52a0\u5e94\u4fc3\u8fdb\u764c\u7ec6\u80de\u4e2d\u7c7b\u82b1\u751f\u9178\u7684\u4ea7\u751f\u3002ELOVL2\u88ab\u9274\u5b9a\u4e3a\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e2dPUFA\u7684\u4ee3\u8c22\u4ecb\u8d28\u3002\u7814\u7a76\u8868\u660e\uff0cFADS2\u53ef\u4ee5\u4fc3\u8fdb\u4e73\u817a\u764c\u4e2d\u7c7b\u82b1\u751f\u9178\u7684\u5408\u6210\u3002\u5982\u524d\u6240\u8ff0\uff0cFADS2\u8fd8\u53ef\u4ee5\u4ece\u68d5\u6988\u9178\u916f\u4e2d\u751f\u4ea7MUFA sapienate\u3002\u8fd9\u79cd\u66ff\u4ee3\u7684\u4ee3\u8c22\u9014\u5f84\u53ef\u786e\u4fdd\u5728SCD\u53d7\u5230\u6291\u5236\u65f6\u4ea7\u751fMUFA\u3002\u4f46\u662f\uff0c\u8fd9\u79cd\u7531\u68d5\u6988\u9178\u916f\u79ef\u7d2f\u4fc3\u8fdb\u7684\u5e95\u7269\u8f6c\u6362\u4e5f\u51cf\u5c11\u4e86\u03b3-\u4e9a\u9ebb\u9178\u7684\u4ea7\u751f\uff0c\u5e76\u53ef\u80fd\u635f\u5bb3\u4fe1\u53f7\u8102\u8d28\uff08\u5305\u62ec\u7c7b\u82b1\u751f\u9178\u548cDHA\uff09\u7684\u4ea7\u751f\u3002FADS1\u548cFADS2\u662fSREBP\u9776\u57fa\u56e0\uff0c\u8868\u660e\u8fd9\u4e9b\u8f6c\u5f55\u56e0\u5b50\u4e5f\u53ef\u4ee5\u8c03\u8282\u8102\u8d28\u4ecb\u8d28\u7684\u4ea7\u751f\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u9664\u4e86\u4fe1\u53f7\u8102\u8d28\u5916\uff0c\u7532\u7f9f\u620a\u9178\u9014\u5f84\u7684\u4ea7\u7269\u4e5f\u53ef\u5f71\u54cd\u764c\u7ec6\u80de\u4e0e\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u6c27\u5316\u56fa\u9187\u4ee3\u8c22\u7269\u7f9f\u57fa\u80c6\u56fa\u9187\u901a\u8fc7\u589e\u52a0\u4fc3\u8fdb\u8f6c\u79fb\u7684\u514d\u75ab\u7ec6\u80de\u6570\u91cf\u540c\u65f6\u963b\u65adT\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u6765\u4ecb\u5bfcHFD\u5bf9\u4e73\u817a\u764c\u8f6c\u79fb\u5f62\u6210\u7684\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u80c6\u56fa\u9187\u542b\u91cf\u7684\u589e\u52a0\u4f1a\u8bf1\u5bfcCD8 + T\u7ec6\u80de\u8870\u7aed\u3002\u56e0\u6b64\uff0c\u764c\u7ec6\u80de\u4ea7\u751f\u7684\u80c6\u56fa\u9187\u589e\u52a0\u53ef\u80fd\u5f62\u6210\u4e00\u4e2a\u5bf9\u514d\u75ab\u7cfb\u7edf\u4e0d\u5229\u7684\u80bf\u7624\u5fae\u73af\u5883\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u5f02\u578b\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u662f\u764c\u7ec6\u80de\u548c\u8102\u80aa\u7ec6\u80de\u7684\u4ee3\u8c22\u5171\u751f\uff0c\u8fd9\u4e9b\u80bf\u7624\u5b9e\u4f53\u5305\u62ec\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u767d\u8840\u75c5\u3002\u764c\u7ec6\u80de\u7684\u5b58\u5728\u8bf1\u5bfc\u8102\u80aa\u7ec6\u80de\u4e2d\u8102\u7c7b\u7684\u5206\u89e3\u548cFAs\u7684\u52a8\u5458\u3002\u8be5\u8fc7\u7a0b\u4f9d\u8d56\u4e8e\u8102\u80aa\u7ec6\u80de\u4e2dFA\u7ed3\u5408\u86cb\u767d4\uff08FABP4\uff09\u7684\u8868\u8fbe\uff0c\u56e0\u4e3aFABP4\u7684\u6291\u5236\u4f1a\u51cf\u5f31\u8102\u8d28\u5206\u89e3\u4f5c\u7528\u548cFAs\u7684\u5206\u6ccc\u3002\u540c\u6837\uff0c\u5728\u4f7f\u7528FABP4\u91ce\u751f\u578b\u6216\u7a7a\u767d\u5c0f\u9f20\u7684\u8f6c\u79fb\u6027\u5375\u5de2\u764c\u539f\u4f4d\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u8bc1\u660e\u8102\u80aa\u7ec6\u80de\u4e2dFABP4\u7684\u8868\u8fbe\u5bf9\u4e8e\u7f51\u819c\uff08\u8179\u90e8\u8102\u80aa\u57ab\u3001\u5375\u5de2\u764c\u8f6c\u79fb\u7684\u4e3b\u8981\u4f4d\u7f6e\uff09\u8f6c\u79fb\u81f3\u5173\u91cd\u8981\u3002\u764c\u7ec6\u80de\u4e0e\u8102\u80aa\u7ec6\u80de\u7684\u5171\u57f9\u517b\u4f1a\u5bfc\u81f4AMPK\u6d3b\u5316\u5e76\u589e\u52a0\u764c\u7ec6\u80de\u4e2d\u7684FAO\u3002\u8fd9\u79cdAMPK\u6fc0\u6d3b\u662f\u7531\u8102\u80aa\u7ec6\u80de\u5206\u6ccc\u7684\u4f9d\u8d56\u4e8eCa2 + \/\u9499\u8c03\u86cb\u767d\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176\uff08CaMKK2\uff09\u4ecb\u5bfc\u7684\u3002\u5728\u4e73\u817a\u764c\u5e72\u7ec6\u80de\uff08BCSC\uff09\u4e2d\uff0cFAO\u548cFA\u7684\u6444\u53d6\u901a\u8fc7\u8102\u80aa\u7ec6\u80de\u5206\u6ccc\u7684\u7626\u7d20\u6fc0\u6d3b\uff0c\u8be5\u673a\u5236\u6fc0\u6d3bJAK \/ STAT3\u4fe1\u53f7\u901a\u8def\uff0c\u8fdb\u800c\u901a\u8fc7STAT3\u4e0eCPT1B\u57fa\u56e0\u542f\u52a8\u5b50\u7684\u7ed3\u5408\u6765\u6fc0\u6d3bFAO\u3002FAO\u5bf9\u8102\u80aa\u7ec6\u80de\u884d\u751f\u7684FAs\u5728\u4e73\u817a\u764c\u5e72\u7ec6\u80de\u7684\u7ef4\u6301\u81f3\u5173\u91cd\u8981\uff0c FAO\u7684\u6291\u5236\u4f5c\u7528\u4f1a\u964d\u4f4eBCSCs\u7684\u589e\u6b96\u548c\u80bf\u7624\u7403\u7684\u5f62\u6210\uff0c\u800cFAO\u7684\u6fc0\u6d3b\u8db3\u4ee5\u6062\u590dSTAT3\u6291\u5236\u7684BCSCs\u7684\u80bf\u7624\u7403\u7684\u5f62\u6210\u3002\u4ee5\u4e0a\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\uff0c\u8102\u80aa\u7ec6\u80de\u884d\u751f\u7684FAs\u662f\u764c\u80bf\u7624\u5e72\u7ec6\u80de\u751f\u6001\u4f4d\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002<\/span><\/p>\n<p style=\"text-align: center; 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text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u6210\u529f\u7684\u6cbb\u7597\u7b56\u7565\u53ef\u80fd\u9700\u8981\u7ed3\u5408\u9488\u5bf9FA\u5408\u6210\u548c\u6444\u53d6\u7684\u6291\u5236\u5242\u3002\u53ef\u4ee5\u4f7f\u7528\u6297\u8840\u7ba1\u751f\u6210\u7597\u6cd5\u6216\u7279\u5b9a\u996e\u98df\u65b9\u6848\u6765\u4f7f\u5916\u6e90\u6027\u8102\u8d28\u7684\u80bf\u7624\u9965\u997f\u5e76\u9632\u6b62\u4ee3\u507f\u3002FASN\u6291\u5236\u5242TVB-2640\u76ee\u524d\u6b63\u5728\u4e0e\u6297\u661f\u5f62\u8840\u7ba1\u7624\uff08NCT03032484\uff09\u4e2d\u7684\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u8d1d\u4f10\u5355\u6297\u8054\u5408\u8fdb\u884c\u4e34\u5e8a\u6d4b\u8bd5\u3002\u9664\u4e86\u672c\u8eab\u963b\u65adFA\u7684\u4f9b\u5e94\u5916\uff0c\u8fd8\u53ef\u4ee5\u9776\u5411\u5c06FAs\u8f6c\u5316\u4e3a\u764c\u75c7\u751f\u957f\u6240\u5fc5\u9700\u7684\u4e0d\u540c\u751f\u7269\u5206\u5b50\u6240\u9700\u7684\u9176\u3002\u901a\u8fc7\u9776\u5411\u9170\u57fa\u8f85\u9176A\u5408\u6210\u9176\u6765\u963b\u6b62FA\u7684\u6fc0\u6d3b\uff0c\u6216\u8005\u901a\u8fc7\u9776\u5411\u9170\u57fa\u8f6c\u79fb\u9176\u6765\u963b\u65ad\u5b83\u4eec\u4e0e\u7518\u6cb9\u4e3b\u94fe\u7684\u8fde\u63a5\uff0c\u8fd9\u5c06\u540c\u65f6\u5f71\u54cd\u5185\u6e90\u6027\u548c\u5916\u6e90\u6027FAs\uff0c\u518d\u6b21\u514b\u670d\u4e86\u8865\u507f\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u5176\u4ed6\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u5229\u7528\u4e86\u9009\u62e9\u6027\u8102\u8d28\u4ee3\u8c22\uff0c\u8fd9\u4e9b\u8102\u8d28\u662f\u7531\u764c\u75c7\u4e2d\u8102\u8d28\u4ee3\u8c22\u6539\u53d8\u6240\u4ea7\u751f\u7684\u3002\u4f8b\u5982\uff0c\u8102\u8d28\u5408\u6210\u589e\u5f3a\u9700\u8981\u51cf\u5c11\u8f85\u56e0\u5b50\uff0c\u5e76\u589e\u52a0\u764c\u7ec6\u80de\u5bf9NADPH\u518d\u751f\u9014\u5f84\u7684\u4f9d\u8d56\u6027\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u963b\u65adPPP\u6216\u82f9\u679c\u9176\u7684\u6d3b\u6027\u964d\u4f4e\u764c\u7ec6\u80de\u4ea7\u751fNADPH\u7684\u80fd\u529b\uff0c\u8fd9\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u663e\u793a\u51fa\u9ad8FA\u751f\u7269\u5408\u6210\u901f\u7387\u800c\u5f15\u8d77\u7ec6\u80de\u6bd2\u6027\u30026-\u78f7\u9178\u8461\u8404\u7cd6\u8131\u6c22\u9176\uff08G6PD\uff09\u7684\u9009\u62e9\u6027\u6291\u5236\u5242polydatin\u901a\u8fc7\u589e\u52a0\u6c27\u5316\u5e94\u6fc0\uff0c\u5728\u8f6c\u79fb\u6027\u820c\u764c\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728VHL\u7f3a\u5931\u7684ccRCC\u7ec6\u80de\u4e2d\uff0c\u6267\u884cFAO\u7684\u80fd\u529b\u964d\u4f4e\u5bfc\u81f4\u8fc7\u591a\u8102\u8d28\u5b58\u50a8\u5bf9\u8c37\u80f1\u7518\u80bd\u751f\u7269\u5408\u6210\u9014\u5f84\u7684\u6291\u5236\u4ea7\u751f\u9009\u62e9\u6027\u654f\u611f\u6027\uff0c\u4ece\u800c\u5bfc\u81f4\u8102\u8d28\u8fc7\u6c27\u5316\u548c\u94c1\u6b7b\u4ea1\u7684\u8bf1\u5bfc\u3002<\/span><\/p>\n<p style=\"text-align: left; text-indent: 2em; margin: 0px; padding: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word; color: #333333; background-color: #ffffff;\"><span style=\"color: #000000; font-family: \u5b8b\u4f53; font-size: 16px;\">\u8102\u8d28\u8c03\u8282\u591a\u79cd\u4fe1\u53f7\u4f20\u5bfc\u8fc7\u7a0b\u5e76\u53c2\u4e0e\u7ec6\u80de\u95f4\u901a\u8baf\u3002\u9776\u5411\u8102\u8d28\u4f9b\u5e94\u53ef\u76f4\u63a5\u5e72\u6270\u8f6c\u5316\u8fc7\u7a0b\u4e2d\u9a71\u52a8\u56e0\u5b50\u7684\u6d3b\u6027\uff0c\u5426\u5219\u53ef\u80fd\u96be\u4ee5\u9776\u5411\u3002CGX1321\u662fWnt\u9170\u57fa\u8f6c\u79fb\u9176PORCN\u7684\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u80c3\u80a0\u9053\u80bf\u7624\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT02675946\u548cNCT03507998\uff09\u3002\u7531\u4e8eWnt\u9170\u5316\u9700\u8981SCD\u4ea7\u751f\u68d5\u6988\u786c\u8102\u9178\uff0c\u56e0\u6b64\u5c06CGX1321\u4e0eFA\u53bb\u9971\u548c\u6291\u5236\u5242\u7ed3\u5408\u4f7f\u7528\u53ef\u4ee5\u66f4\u6709\u6548\u5730\u963b\u6b62Wnt\u6d3b\u6027\uff0c\u4f46\u8fd9\u53ef\u80fd\u4f1a\u589e\u5f3a\u4e0eWnt\u9014\u5f84\u6291\u5236\u76f8\u5173\u7684\u6bd2\u6027\u3002\u8102\u8d28\u53c2\u4e0e\u80bf\u7624\u5185\u4e0d\u540c\u7ec6\u80de\u7fa4\u4f53\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5f3a\u8c03\u4e86\u5728\u5408\u9002\u7684\u4f53\u5185\u6a21\u578b\u4e2d\u7814\u7a76\u5e72\u6270\u8102\u8d28\u4ee3\u8c22\u7f51\u7edc\u5f71\u54cd\u7684\u5fc5\u8981\u6027\uff0c\u56e0\u4e3a\u9776\u5411\u8102\u8d28\u4ee3\u8c22\u53ef\u4ee5\u4fc3\u8fdb\u4e0e\u6297\u68c0\u67e5\u70b9\u6cbb\u7597\u76f8\u7ed3\u5408\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u4e00\u65e6\u9488\u5bf9FA\u548c\u8102\u8d28\u4ee3\u8c22\u7684\u4e0d\u540c\u9636\u6bb5\u5408\u9002\u7684\u836f\u7406\u5b66\u836f\u7269\u95ee\u4e16\uff0c\u5c31\u53ef\u4ee5\u5236\u5b9a\u51fa\u5408\u7406\u7684\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u3002<\/span><\/p>\n<p><span style=\"font-size: 21px; 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word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456245082&amp;idx=1&amp;sn=7cb0b8f302f6746066637f7abfc576ef&amp;chksm=8d748c9bba03058d81ec66f0da9a87ebbff4088e871524e32cf318c3dbe67fb1e1b2de6ad417&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244984&amp;idx=1&amp;sn=9203285637478abe17fea957bb4a4b3c&amp;chksm=8d748d39ba03042fceb79cdd77d520d07e613fc04f9be12fb7a759b7fb11b0581066a81689e0&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244984&amp;idx=2&amp;sn=ca672f89970541c6688cbb47d25ee379&amp;chksm=8d748d39ba03042f5707584ba5568c835db80604229d09f6bc322ef9f567bac3005ba771b06c&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">BD Accuri C5\u6d41\u5f0f\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244479&amp;idx=1&amp;sn=7b577b34dc059d84b6330ca9d307e813&amp;chksm=8d748f3eba030628f0525ced9a39e1d8333288be7d4886ff71cb9c0d3354bcdeee99c9126fe4&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">BD FACSJAZZ\u6d41\u5f0f\u7ec6\u80de\u5206\u9009\u4eea\u57fa\u672c\u53c2\u6570\u53ca\u5e94\u7528\u7b80\u4ecb<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244468&amp;idx=1&amp;sn=f21f2d1f9b0c28d542d9cc22ab188c8f&amp;chksm=8d748f35ba0306231171b9b0483f6f8529290597e4838c97e7facca928ab176b05d1aa0ed2e2&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">BD Accuri C5\u6d41\u5f0f\u7ec6\u80de\u4eea\u4f7f\u7528\u89c4\u8303\u53ca\u64cd\u4f5c\u6d41\u7a0b<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456245067&amp;idx=1&amp;sn=f6c737e518a915bb049d238672b3bbbc&amp;chksm=8d748c8aba03059c25cf2438f49a31f98a497aaab659b840076649f8a652e4b1797ca5ce8c05&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456245033&amp;idx=1&amp;sn=b366528abeb3829a731382b3978109f6&amp;chksm=8d748ce8ba0305fefcc4b8cf17c9c5b5ff3ebbfc663c3fbf51c276b7fd75895c7a13affe6d81&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456245098&amp;idx=1&amp;sn=0faf5a71d7f4a2df2dd10b0dd3515e47&amp;chksm=8d748cabba0305bdb52ba683d76a20f5494cf029fe18895a5c875825223e6feeb7d2b381cd9b&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244905&amp;idx=1&amp;sn=9e75242aa7a3bbc991e76d7987f0b503&amp;chksm=8d748d68ba03047e146a11c1337eb57a148665f60dc7c4bb429d3abe72b6241f430444142218&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244905&amp;idx=2&amp;sn=12a088d6ecc91e9b33a922c3df9a14c6&amp;chksm=8d748d68ba03047ee6e4930be21e0962aca15fce3e345da23debe4d6d92589928b09d2e769ac&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">ZESS Axio Observer3\u5012\u7f6e\u8367\u5149\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244252&amp;idx=1&amp;sn=0ac461362a91fa5205f559c5199a95c2&amp;chksm=8d748fddba0306cb105aea2a797a676fd3b9d54955ea9a5fb0676b052a90ef121543e7c840c4&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244231&amp;idx=1&amp;sn=ed16d5ceefbca27277c98714731bb110&amp;chksm=8d748fc6ba0306d06624388772e689e81cc362698ef1096324683f46d7761c20de6d827fbdaa&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244183&amp;idx=1&amp;sn=aa2a848ab67d620f93862060b9955562&amp;chksm=8d749016ba031900d1c894b33982017d26a937119e20a96ff078189dec736f2b97e1059f22fe&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244176&amp;idx=1&amp;sn=7f10fabdcf7f0d950a46240ec5fe15fb&amp;chksm=8d749011ba031907790577f28948aed880b0363c1347a4277d1c18fa771defb097ef9edb188f&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244088&amp;idx=1&amp;sn=21d68a70f7bca71bfdde72c0d67f2a98&amp;chksm=8d7490b9ba0319af09932fbe11d466d7c89a0b0a075a6452872b5de237d1bc7b1ecaae24dc81&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244084&amp;idx=1&amp;sn=b88786b622f65d63e362f4c5c77bbeaf&amp;chksm=8d7490b5ba0319a34e65c5d39d2bffa07bf8950cb53409465a4889520feceed2f70519d6f84e&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244079&amp;idx=1&amp;sn=7b1487d81a45eec42e9d06c31ee0d24b&amp;chksm=8d7490aeba0319b88635d82077a37c473cf27f9877a4fb7928cfbb26169701804b657cae179f&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\">\u5982\u4f55\u6d4b\u91cfWestern Blot\u6761\u5e26\u7070\u5ea6\u503c\uff1f(GelPro\u8f6f\u4ef6\u4f7f\u7528\u65b9\u6cd5)<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; font-family: -apple-system-font, BlinkMacSystemFont, 'Helvetica Neue', 'PingFang SC', 'Hiragino Sans GB', 'Microsoft YaHei UI', 'Microsoft YaHei', Arial, sans-serif; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; box-sizing: border-box !important; word-wrap: break-word !important;\"><a style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0); cursor: pointer; max-width: 100%; box-sizing: border-box !important; word-wrap: break-word !important;\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456244074&amp;idx=1&amp;sn=f5cbff4aabcf36dce3b6429e52b77305&amp;chksm=8d7490abba0319bd2818ce0a5f6775afd2b2cac8d959ce73bf8040165e5e02b46299438e6e53&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\" data-itemshowtype=\"0\" data-linktype=\"2\"><span style=\"max-width: 100%; font-size: 16px; box-sizing: border-box !important; word-wrap: break-word !important;\">\u5b9e\u9a8c\u4e2d\u5982\u4f55\u6311\u9009\u5230\u4e00\u652f\u597d\u7528\u7684\u6297\u4f53\uff1f<\/span><\/a><\/p>\n<p style=\"max-width: 100%; min-height: 1em; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: medium; text-align: center; line-height: 2em; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%; min-height: 1em; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: medium; text-align: center; line-height: 2em; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\"><span style=\"max-width: 100%; font-size: 12px; color: #595757; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\">\u2014 THE \u00a0END \u2014<\/span><\/p>\n<p style=\"max-width: 100%; min-height: 1em; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: medium; text-align: center; line-height: 2em; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%; min-height: 1em; letter-spacing: 0.544px; white-space: normal; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; background-color: #ffffff; text-align: center; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\"><img decoding=\"async\" class=\"rich_pages\" style=\"box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important; visibility: visible !important; width: 155px !important;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2022\/04\/wxsync-2022-04-02b1fa2647f727640451312635548126.jpeg\" data-ratio=\"1\" data-type=\"jpeg\" data-w=\"258\" data-s=\"300,640\" data-cropsely2=\"155\" data-cropsely1=\"0\" data-cropselx2=\"154\" data-cropselx1=\"0\" \/><\/p>\n<p style=\"max-width: 100%; min-height: 1em; letter-spacing: 0.544px; white-space: normal; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; background-color: #ffffff; text-align: center; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\"><span style=\"max-width: 100%; font-size: 12px; color: #888888; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\">\u5173\u6ce8\u672c\u53f7\u56de\u590d201118\u5373\u53ef\u83b7\u53d6pdf\u539f\u6587~<\/span><\/p>\n<p style=\"max-width: 100%; min-height: 1em; letter-spacing: 0.544px; white-space: normal; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; background-color: #ffffff; text-align: center; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px; margin-left: 8px; max-width: 100%; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 16px; widows: 1; line-height: 2em; text-align: right; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\"><span style=\"max-width: 100%; font-size: 15px; background-color: #f9eda6; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\">\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n<section style=\"margin-right: 8px; margin-left: 8px; max-width: 100%; letter-spacing: 0.544px; white-space: normal; background-color: #ffffff; color: #000000; font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 16px; widows: 1; line-height: 2em; text-align: right; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\"><span style=\"max-width: 100%; font-size: 15px; background-color: #f9eda6; box-sizing: border-box !important; word-wrap: break-word !important; overflow-wrap: break-word !important;\">\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<blockquote><p>\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\u5fae\u79d1\u4eab \uff0c\u4f5c\u8005\u840c\u840c\u5b9d\u513f<\/p><\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bfb \u8102\u8d28\u662f\u4e00\u7c7b\u9ad8\u5ea6\u590d\u6742\u7684\u751f\u7269\u5206\u5b50\uff0c\u4e0d\u4ec5\u662f\u6784\u6210\u751f\u7269\u819c\u7684\u57fa\u7840\u7ed3\u6784\uff0c\u800c\u4e14\u8fd8\u662f\u4fe1\u53f7\u5206\u5b50\u548c\u80fd\u91cf\u6765\u6e90\u3002\u8102\u8d28\u4ee3\u8c22\u6539\u53d8\u662f\u764c\u75c7\u4e2d\u6700\u7a81\u51fa\u7684\u4ee3\u8c22\u6539\u53d8\u4e4b\u4e00\uff0c\u8102\u8d28\u5408\u6210\u6216\u6444\u53d6\u7684\u589e\u5f3a\u6709\u52a9\u4e8e\u764c\u7ec6\u80de\u7684\u5feb\u901f\u751f\u957f\u548c\u80bf&hellip;<\/p>\n","protected":false},"author":1,"featured_media":3286,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[57],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3289"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3289"}],"version-history":[{"count":1,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3289\/revisions"}],"predecessor-version":[{"id":4324,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3289\/revisions\/4324"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3286"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3289"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}