{"id":3295,"date":"2020-11-17T18:41:15","date_gmt":"2020-11-17T10:41:15","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2020\/11\/17\/%e7%bb%bc%e8%bf%b0-%e5%be%ae%e7%94%9f%e7%89%a9-%e8%82%a0-%e8%84%91%e8%bd%b4%ef%bc%9a%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%96%be%e7%97%85%e6%96%b0%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%9d%e8%b7%af\/"},"modified":"2020-11-17T18:41:15","modified_gmt":"2020-11-17T10:41:15","slug":"%e7%bb%bc%e8%bf%b0-%e5%be%ae%e7%94%9f%e7%89%a9-%e8%82%a0-%e8%84%91%e8%bd%b4%ef%bc%9a%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%96%be%e7%97%85%e6%96%b0%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%9d%e8%b7%af","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2020\/11\/17\/%e7%bb%bc%e8%bf%b0-%e5%be%ae%e7%94%9f%e7%89%a9-%e8%82%a0-%e8%84%91%e8%bd%b4%ef%bc%9a%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%96%be%e7%97%85%e6%96%b0%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%9d%e8%b7%af\/","title":{"rendered":"\u7efc\u8ff0 | \u5fae\u751f\u7269-\u80a0-\u8111\u8f74\uff1a\u4e2d\u67a2\u795e\u7ecf\u75be\u75c5\u65b0\u7684\u6cbb\u7597\u601d\u8def"},"content":{"rendered":"
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\u4f20\u7edf\u7684\u836f\u7406\u5b66\u548c\u6bd2\u7406\u5b66\u9886\u57df\u5f00\u59cb\u8003\u8651\u6211\u4eec\u7684\u80a0\u9053\u83cc\u7fa4\u5bf9\u5bbf\u4e3b\u751f\u7406\u5b66\u7684\u5b9e\u8d28\u6027\u5f71\u54cd\u3002\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u6b63\u5728\u6210\u4e3a\u4e00\u4e2a\u7279\u6b8a\u7684\u611f\u5174\u8da3\u9886\u57df\u548c\u6709\u6548\u6cbb\u7597\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u6f5c\u5728\u65b0\u6cbb\u7597\u9776\u70b9\uff0c\u6b64\u5916\u4e5f\u662f\u836f\u7269\u526f\u4f5c\u7528\u7684\u6f5c\u5728\u539f\u56e0\u3002\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u4fe1\u53f7\u53ef\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u53d1\u751f\uff0c\u5305\u62ec\u901a\u8fc7\u514d\u75ab\u7cfb\u7edf\u3001\u52df\u96c6\u5bbf\u4e3b\u795e\u7ecf\u5316\u5b66\u4fe1\u53f7\u3001\u76f4\u63a5\u80a0\u795e\u7ecf\u7cfb\u7edf\u9014\u5f84\u548c\u8ff7\u8d70\u795e\u7ecf\u4ee5\u53ca\u4ea7\u751f\u7ec6\u83cc\u4ee3\u8c22\u7269\u3002\u5728\u51e0\u79cd\u7cbe\u795e\u75be\u75c5\u548c\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e2d\u63cf\u8ff0\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u7684\u6539\u53d8\u3002\u76ee\u524d\u6b63\u5728\u7814\u7a76\u5c06\u7cbe\u795e\u751f\u7269\u5236\u5242\u3001\u6d3b\u4f53\u751f\u7269\u6cbb\u7597\u836f\u7269\u6216\u5bf9\u5927\u8111\u6709\u76ca\u4f5c\u7528\u901a\u8fc7\u7ec6\u83cc\u4ecb\u5bfc\u7684\u7269\u8d28\u4f5c\u4e3a\u7cbe\u795e\u75be\u75c5\u548c\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u4ee5\u53ca\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08\u53ef\u80fd\uff09\u7684\u76f4\u63a5\u548c<\/span>\/<\/span>\u6216\u8f85\u52a9\u6cbb\u7597\uff0c\u5b83\u4eec\u53ef\u80fd\u6210\u4e3a\u8111\u75be\u75c5\u4e34\u5e8a\u7ba1\u7406\u4e2d\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u539f\u540d<\/span><\/strong>\uff1a<\/span><\/span>Microbiota-gut-brain axis: new therapeutic opportunities<\/span><\/span><\/p>\n

\u8bd1\u540d<\/span><\/strong>\uff1a\u4e2d\u67a2\u795e\u7ecf\u75be\u75c5\u65b0\u7684\u6cbb\u7597\u601d\u8def\u2014\u2014\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74<\/span><\/span><\/p>\n

\u671f\u520a<\/span><\/span><\/strong><\/span>\uff1a<\/span><\/span>Annual review ofpharmacology and toxicology<\/span><\/p>\n

IF<\/span>\uff1a<\/span><\/strong>11.25<\/span><\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4<\/span>\uff1a<\/span><\/strong>2019.09<\/span><\/span>
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\u901a\u8baf\u4f5c\u8005<\/span><\/strong>\uff1a<\/span><\/span>John F Cryan<\/span><\/p>\n

\u4f5c\u8005\u5355\u4f4d<\/span>\uff1a<\/span><\/span><\/strong><\/span>\u79d1\u514b\u5927\u5b66<\/span>APC<\/span>\u7231\u5c14\u5170\u5fae\u751f\u7269\u7ec4<\/span>&<\/span>\u89e3\u5256\u5b66\u548c\u795e\u7ecf\u79d1\u5b66\u7cfb<\/span><\/p>\n


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1 \u5fae\u751f\u7269-\u80a0-\u8111\u8f74<\/span><\/strong><\/p>\n

1.1 \u80a0\u9053\u5fae\u751f\u7269<\/span><\/strong><\/p>\n

\u5c31\u9965\u997f\u548c\u9971\u8179\u611f\u4fe1\u53f7\u7684\u4e2d\u67a2\u63a7\u5236\u800c\u8a00\uff0c\u53cc\u5411\u80a0<\/span>–<\/span>\u8111\u4ea4\u6d41\u7684\u5b58\u5728\u4f3c\u4e4e\u786e\u5b9e\u5b58\u5728\u3002\u5e76\u4e14\uff0c\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0c\u8fd9\u79cd\u4ea4\u6d41\u66f4\u5e7f\u6cdb\u5730\u6d89\u53ca\u8ba4\u77e5\u3001\u793e\u4f1a\u884c\u4e3a\u3001\u6050\u60e7\u8868\u8fbe\u548c\u5e94\u6fc0\u53cd\u5e94\u3002\u5305\u62ec\u53ef\u4e0e\u80c3\u80a0\u9053\u75be\u75c5\u548c\u529f\u80fd\u6027\u80c3\u80a0\u9053\u75be\u75c5\uff08\u4e0d\u5b58\u5728\u660e\u663e\u80c3\u80a0\u9053\u75c5\u7406\u5b66\u4f46\u5177\u6709\u8f83\u9ad8\u5fc3\u7406\u6210\u5206\u7684\u75be\u75c5\uff09\u76f8\u5173\uff0c\u5e76\u53ef\u5bfc\u81f4\u91cd\u5ea6\u80c3\u80a0\u9053\u4e0d\u9002\u3002\u6b64\u5916\uff0c\u6025\u6027\u548c\u6162\u6027\u5e94\u6fc0\u3001\u7126\u8651\u548c\u6291\u90c1\u5747\u53d7\u5230\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u7684\u5f71\u54cd\u3002\u8be5\u9886\u57df\u7684\u5927\u591a\u6570\u5b66\u8005\u8ba4\u4e3a\u80a0\u9053\u7684\u5b9a\u690d\u4e3b\u8981\u53d1\u751f\u5728\u51fa\u751f\u65f6\uff0c\u901a\u8fc7\u5256\u8179\u4ea7\u5206\u5a29\u7684\u5a74\u513f\u7684\u80a0\u9053\u83cc\u7fa4\u4e0e\u9634\u9053\u5206\u5a29\u975e\u5e38\u4e0d\u540c\uff0c\u524d\u8005\u5305\u542b\u5b58\u5728\u4e8e\u76ae\u80a4\u548c\u5206\u5a29\u5ba4\u7684\u5fae\u751f\u7269\uff0c\u5e76\u4e14\u8fd9\u4e9b\u5a74\u513f\u7684\u53cc\u6b67\u6746\u83cc\u3001\u62df\u6746\u83cc\u548c\u4e73\u9178\u6746\u83cc\u5b9a\u690d\u8f83\u4f4e\u3002\u540e\u8005\u7684\u7279\u5f81\u66f4\u63a5\u8fd1\u4e8e\u6bcd\u4f53\u9634\u9053\u5fae\u751f\u7269\u7ec4\u3002\u5728\u51fa\u751f\u540e\u7684\u524d\u4e24\u5e74\u5185\uff0c\u5256\u8179\u4ea7\u5a74\u513f\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7279\u5f81\u53d8\u5f97\u66f4\u63a5\u8fd1\u7ecf\u9634\u9053\u5206\u5a29\u5a74\u513f\uff1b\u7136\u800c\uff0c\u4e0d\u540c\u5fae\u751f\u7269\u5b9a\u690d\u7684\u529f\u80fd\u6548\u5e94\u53ef\u80fd\u6301\u7eed\u5b58\u5728\uff0c\u5e76\u88ab\u5047\u5b9a\u4e0e\u513f\u7ae5\u80a5\u80d6\u548c\u54ee\u5598\u7684\u76f8\u5bf9\u98ce\u9669\u589e\u52a0\u76f8\u5173\u3002<\/span><\/p>\n

\u518d\u8005\uff0c\u751f\u547d\u65e9\u671f\u80a0\u9053\u83cc\u7fa4\u7684\u7ec4\u6210\u8fdb\u4e00\u6b65\u4e5f\u53d7\u5230\u591a\u79cd\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u4ea7\u524d\u6297\u751f\u7d20\u4f7f\u7528\u3001\u6bcd\u4e73\u5582\u517b\u3001\u51fa\u751f\u540e\u7b2c\u4e00\u5e74\u7684\u751f\u957f\u548c\u5730\u7406\u7684\u5f71\u54cd\u3002\u5728\u6574\u4e2a\u751f\u547d\u8fc7\u7a0b\u4e2d\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u7ec4\u6210\u8fdb\u4e00\u6b65\u53d7\u5230\u996e\u98df\u3001\u5730\u7406\u3001\u8fd0\u52a8\u6c34\u5e73\u3001\u6297\u751f\u7d20\u548c\u5176\u4ed6\u836f\u7269\u7684\u5f71\u54cd\uff08\u56fe<\/span>1<\/span>\uff09\u3002\u996e\u98df\u5728\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u7ec4\u6210\u548c\u591a\u6837\u6027\u4e2d\u53d1\u6325\u5de8\u5927\u4f5c\u7528\uff0c\u6539\u53d8\u996e\u98df\u4f1a\u8bf1\u53d1\u80a0\u9053\u5fae\u751f\u7269\u8c31\u7684\u5feb\u901f\u53d8\u5316\u3002\u6bd4\u5982\uff0c\u5730\u4e2d\u6d77\u996e\u98df\u4e0e\u7279\u5b9a\u7684\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u548c\u8bb8\u591a\u6709\u76ca\u7684\u5065\u5eb7\u5f71\u54cd\u76f8\u5173\uff1b\u4e0d\u826f\u996e\u98df\uff08\u5305\u62ec\u897f\u65b9\u98ce\u683c\u7684\u996e\u98df\uff09\u5bf9\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u6709\u5bb3\u5f71\u54cd\u4e0e\u4ee3\u8c22\u7efc\u5408\u5f81\u60a3\u75c5\u7387\u7684\u4e0a\u5347\u6709\u5173\u3002<\/span><\/p>\n

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\u56fe<\/span>1 <\/span>\u5f71\u54cd\u80a0\u9053\u83cc\u7fa4\u7279\u5f81\u7684\u56e0\u7d20\u3002\u591a\u79cd\u56e0\u7d20\u53ef\u80fd\u5728\u6574\u4e2a\u751f\u547d\u5468\u671f\u4e2d\u79ef\u6781\u548c\u6d88\u6781\u5730\u5f71\u54cd\u80a0\u9053\u83cc\u7fa4\u8c31\u7684\u7ec4\u6210\u548c\u591a\u6837\u6027\u3002<\/span>
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1.2 \u5fae\u751f\u7269-\u80a0-\u8111\u8f74\u901a\u8baf\u80cc\u540e\u7684\u4fe1\u53f7\u673a\u5236<\/span><\/strong><\/p>\n

\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u7684\u4fe1\u53f7\u53ef\u901a\u8fc7\u591a\u79cd\u673a\u5236\u53d1\u751f\u3002\u80a0\u9053\u5fae\u751f\u7269\u53ef\u4ee5\u4ea7\u751f\u751f\u7269\u6d3b\u6027\u80bd\uff0c\u5305\u62ec\u795e\u7ecf\u9012\u8d28\u3001\u6b21\u7ea7\u80c6\u6c41\u9178\u7684\u8f6c\u5316\u3001\u77ed\u94fe\u8102\u80aa\u9178\uff08<\/span>SCFAs<\/span>\uff09\u3001\u652f\u94fe\u6c28\u57fa\u9178\u548c\u80a0\u9053\u6fc0\u7d20\u3002<\/span>SCFA<\/span>\uff08\u5305\u62ec\u918b\u9178\u76d0\u3001\u4e01\u9178\u76d0\u3001\u4e19\u9178\u76d0\u548c\u4e73\u9178\u76d0\uff09\u53ef\u8fdb\u5165\u5faa\u73af\u7cfb\u7edf\uff0c\u5e76\u53ef\u80fd\u901a\u8fc7\u8be5\u9014\u5f84\u5411\u5927\u8111\u53d1\u51fa\u4fe1\u53f7\u3002\u5fae\u751f\u7269\u4e5f\u53ef\u4ee5\u4ecb\u5bfc\u8272\u6c28\u9178\u7684\u4ee3\u8c22\uff0c\u4ece\u800c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u8c03\u8282<\/span>5-<\/span>\u7f9f\u8272\u80fa\u4fe1\u53f7\u3002\u591a\u5df4\u80fa\u3001\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u3001<\/span>GABA<\/span>\u548c\u4e59\u9170\u80c6\u78b1\u4e5f\u53ef\u7531\u80a0\u9053\u5fae\u751f\u7269\u5408\u6210\u3002\u80a0\u58c1\u7531\u80a0\u795e\u7ecf\u7cfb\u7edf\uff08<\/span>ENS<\/span>\uff09\u652f\u914d\uff0c\u4e3b\u8981\u8d1f\u8d23\u80a0\u9053\u8fd0\u52a8\uff0c\u8fd9\u53ef\u4ee5\u88ab\u795e\u7ecf\u9012\u8d28\u548c<\/span>SCFA<\/span>\u9776\u5411\u8c03\u63a7\u3002\u6b64\u5916\uff0c\u5fae\u751f\u7269\u542b\u6709\u5fae\u751f\u7269\u76f8\u5173\u7684\u5206\u5b50\u6a21\u5f0f\uff0c\u53ef\u88ab<\/span>ENS<\/span>\u4e2d\u7684<\/span>toll<\/span>\u6837\u53d7\u4f53\u8bc6\u522b\u3002\u4e8b\u5b9e\u4e0a\uff0c\u514d\u75ab\u4fe1\u53f7\u662f\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u4fe1\u53f7\u53d1\u751f\u7684\u91cd\u8981\u673a\u5236\u3002\u80a0\u9053\u4e2d\u8fd8\u542b\u6709\u5bc6\u96c6\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u80a0\u9053\u4e0a\u76ae\u7c98\u6db2\u5c42\u7684\u7269\u7406\u5c4f\u969c\u4e4b\u540e\uff0c\u63d0\u4f9b\u4e86\u62b5\u5fa1\u75c5\u539f\u4f53\u7684\u7b2c\u4e8c\u9053\u9632\u7ebf\u3002\u80a0\u9053\u83cc\u7fa4\u53ef\u5f71\u54cd\u4fc3\u708e\u548c\u6297\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u8fdb\u800c\u53ef\u901a\u8fc7\u5faa\u73af\u7cfb\u7edf\u5411\u5927\u8111\u53d1\u51fa\u4fe1\u53f7\u3002<\/span><\/p>\n

\u8ff7\u8d70\u795e\u7ecf\u4e0e\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u4fe1\u53f7\u4f20\u5bfc\u5bc6\u5207\u76f8\u5173\uff0c\u662f\u80a0\u9053\u548c\u5927\u8111\u4e4b\u95f4\u4ea4\u6d41\u7684\u5173\u952e\u6a21\u5f0f\u4e4b\u4e00\u3002\u8ff7\u8d70\u795e\u7ecf\u5207\u65ad\u672f\u662f\u4e00\u79cd\u5916\u79d1\u624b\u672f\uff0c\u5e38\u7528\u4e8e\u6cbb\u7597\u6d88\u5316\u6027\u6e83\u75a1\u75c5\uff0c\u88ab\u62a5\u9053\u5176\u4e0e\u53d1\u751f\u5e15\u91d1\u68ee\u75c5\u7684\u98ce\u9669\u964d\u4f4e\u76f8\u5173\u3002\u6b64\u5916\uff0c\u5728\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u9f20\u674e\u7cd6\u4e73\u6746\u83cc\u7684\u8bb8\u591a\u6709\u76ca\u4f5c\u7528\u5728\u8ff7\u8d70\u795e\u7ecf\u5207\u65ad\u672f\u540e\u88ab\u6d88\u9664\uff0c\u8fd9\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u8868\u660e\u4e86\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u7684\u5b58\u5728\uff0c\u53ca\u8ff7\u8d70\u795e\u7ecf\u7684\u5173\u952e\u4f5c\u7528\u3002\u6700\u8fd1\uff0c\u5229\u7528\u5149\u9057\u4f20\u5b66\u523a\u6fc0\u8bc1\u660e\u4e86\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u5b58\u5728\u8ff7\u8d70\u795e\u7ecf\u80a0<\/span>–<\/span>\u8111\u8f74\u901a\u8def\u3002\u5e76\u4e14\u8bc1\u660e\uff0c\u80a0\u5185\u5206\u6ccc\u7ec6\u80de\u91ca\u653e\u7684\u8c37\u6c28\u9178\u53ef\u6fc0\u6d3b\u8fd9\u4e9b\u8ff7\u8d70\u795e\u7ecf\u7684\u4f20\u5165\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2 \u8111\u90e8\u75be\u75c5\u7684\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u6539\u53d8<\/span><\/strong><\/p>\n

2.1 \u5e94\u6fc0<\/span><\/strong><\/p>\n

\u5e94\u6fc0\u5728\u6539\u53d8\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u6025\u6027\u5e94\u6fc0\u53ef\u76f4\u63a5\u6fc0\u6d3b<\/span>HPA<\/span>\u8f74\uff0c\u4ee5\u4fbf\u5bf9\u5e94\u6fc0\u6e90\u505a\u51fa\u9002\u5f53\u53cd\u5e94\uff1b\u7136\u800c\uff0c\u957f\u671f\u3001\u6162\u6027\u5e94\u6fc0\u53ef\u5f15\u8d77<\/span>HPA<\/span>\u8f74\u6fc0\u6d3b\u7d0a\u4e71\u3002\u6709\u5927\u91cf\u8bc1\u636e\u63cf\u8ff0\u4e86\u5305\u62ec\u556e\u9f7f\u7c7b\u52a8\u7269\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u5728\u5185\u7684\u51e0\u79cd\u5bbf\u4e3b\u4e2d\u5e94\u6fc0\u8bf1\u5bfc\u7684\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u7684\u6539\u53d8\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u6297\u751f\u7d20\u3001\u7f3a\u4e4f\u6bcd\u4e73\u5582\u517b\u3001\u5256\u8179\u4ea7\u3001\u611f\u67d3\u3001\u66b4\u9732\u4e8e\u5e94\u6fc0\u548c\u5176\u4ed6\u73af\u5883\u56e0\u7d20\uff0c\u4ee5\u53ca\u5bbf\u4e3b\u9057\u4f20\u6539\u53d8\u751f\u547d\u65e9\u671f\u5fae\u751f\u7269\u7279\u5f81\uff0c\u53ef\u5f71\u54cd\u5e94\u6fc0\u76f8\u5173\u7684\u751f\u7406\u548c\u884c\u4e3a\u3002\u8bb8\u591a\u7814\u7a76\u63cf\u8ff0\u4e86\u80a0\u6613\u6fc0\u7efc\u5408\u5f81\uff08<\/span>IBS<\/span>\uff09\u7684\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u7684\u6539\u53d8\u3002\u9664\u540e\u671f\u5a74\u513f\u80c3\u80a0\u9053\u75c7\u72b6\u548c\u8fc7\u654f\u53cd\u5e94\u5916\uff0c\u6709\u4ea7\u524d\u5e94\u6fc0\u7684\u5973\u6027\u4e5f\u4f1a\u5bfc\u81f4\u5a74\u513f\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u6539\u53d8\u3002\u901a\u8fc7\u4e0d\u826f\u751f\u6d3b\u4e60\u60ef\u66b4\u9732\u4e8e\u538b\u529b\u548c\u7126\u8651\u4e5f\u4f1a\u5f71\u54cd\u538b\u529b\u76f8\u5173\u7684\u6291\u90c1\u72b6\u6001\uff0c\u5176\u80a0\u9053\u83cc\u7fa4\u7279\u5f81\u76ee\u524d\u4e5f\u5728\u7814\u7a76\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2.2 \u91cd\u5ea6\u6291\u90c1\u75c7<\/span><\/strong><\/p>\n

\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u91cd\u5ea6\u6291\u90c1\u75c7\uff08<\/span>MDD<\/span>\uff09\u60a3\u8005\u4e0e\u5065\u5eb7\u5bf9\u7167\u7ec4\u76f8\u6bd4\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u6539\u53d8\uff0c\u7caa\u4fbf\u5fae\u751f\u7269\u4e30\u5bcc\u5ea6\u964d\u4f4e\u3002\u6709\u7814\u7a76\u901a\u8fc7\u7caa\u83cc\u79fb\u690d\u4f7f\u7126\u8651\u548c\u6291\u90c1\u8868\u578b\u5728\u53d7\u8bd5\u8005\u4e2d\u8868\u73b0\uff0c\u8fd9\u8868\u660e\u80a0\u9053\u83cc\u7fa4\u5728<\/span>MDD<\/span>\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u6700\u8fd1\u4e00\u9879\u5bf9<\/span>Flemish<\/span>\u80a0\u9053\u83cc\u7fa4\u7684\u5927\u89c4\u6a21\u7814\u7a76\u9879\u76ee\u4e5f\u786e\u5b9a\u4e86\u6291\u90c1\u4eba\u7fa4\u4e2d\u80a0\u9053\u83cc\u7fa4\u7279\u5f81\u5b58\u5728\u5dee\u5f02\uff0c\u5728\u53bb\u9664\u6297\u6291\u90c1\u836f\u7269\u7684\u6df7\u6742\u6548\u5e94\u540e\uff0c\u5dee\u5f02\u4ecd\u7136\u5b58\u5728\u3002\u4f46\u65b0\u53d1\u73b0\u662f\u6291\u90c1\u4eba\u7fa4\u4e2d\u4e0d\u5b58\u5728<\/span>Coprococcus<\/span><\/em>\u548c<\/span>Dialister<\/span><\/em>\uff0c\u800c\u5b83\u4eec\u5728\u975e\u6291\u90c1\u4eba\u7fa4\u4e2d\u7684\u5b58\u5728\u4e0e\u751f\u6d3b\u8d28\u91cf\u8bc4\u5206\u5448\u6b63\u76f8\u5173\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\u80a0\u9053\u5fae\u751f\u7269\u5728\u8c03\u8282\u7cbe\u795e\u75be\u75c5\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2.3 \u5e15\u91d1\u68ee\u75c5<\/span><\/strong><\/p>\n

\u76ee\u524d\u5927\u91cf\u7814\u7a76\u5747\u63cf\u8ff0\u4e86\u60a3<\/span>PD<\/span>\u7684\u60a3\u8005\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u4f1a\u6539\u53d8\u3002\u5728<\/span>PD<\/span>\u60a3\u8005\u7684\u75c5\u60c5\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u5305\u62ec\u4e0e\u80a0\u9053\u76f8\u5173\u7684\u75c7\u72b6\uff08\u4e3b\u8981\u662f\u4fbf\u79d8\uff09\uff0c\u56e0\u800c\u6709\u5b66\u8005\u5047\u8bbe<\/span>PD<\/span>\u7684\u53d1\u751f\u59cb\u4e8e\u80a0\u9053\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4ece<\/span>PD<\/span>\u60a3\u8005\u5230<\/span>PD<\/span>\u5c0f\u9f20\u6a21\u578b\u7684\u7caa\u83cc\u79fb\u690d\u5747\u5bfc\u81f4\u8fd0\u52a8\u7f3a\u9677\u548c\u795e\u7ecf\u708e\u75c7\uff0c\u8fd9\u4e3a\u80a0\u9053\u83cc\u7fa4\u4e0e<\/span>PD<\/span>\u76f8\u5173\u63d0\u4f9b\u4e86\u8bc1\u636e\u3002\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8868\u660e\uff0c\u63a5\u53d7\u8ff7\u8d70\u795e\u7ecf\u5207\u65ad\u672f\u6cbb\u7597\u6d88\u5316\u6027\u6e83\u75a1\u75c5\u7684\u4e2a\u4f53\u968f\u7740\u5e74\u9f84\u589e\u957f\u53d1\u751f<\/span>PD<\/span>\u7684\u98ce\u9669\u964d\u4f4e\uff0c\u8bf4\u660e\u80a0\u9053\u83cc\u7fa4\u8bf1\u5bfc<\/span>PD<\/span>\u7684\u53d1\u751f\u53ef\u80fd\u4e0e\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u4fe1\u53f7\u7684\u4f20\u5bfc\u6709\u5173\u3002\u6b64\u5916\uff0c\u6700\u8fd1\u7684\u4e00\u9879\u835f\u8403\u5206\u6790\u4e5f\u5df2\u7ecf\u786e\u5b9a\u6839\u9664\u5e7d\u95e8\u87ba\u6746\u83cc\u5728\u6539\u5584<\/span>PD<\/span>\u75c7\u72b6\u65b9\u9762\u6709\u660e\u663e\u7684\u83b7\u76ca\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2.4 \u963f\u5c14\u8328\u6d77\u9ed8\u75c5<\/span><\/strong><\/p>\n

AD<\/span>\u4e5f\u88ab\u8ba4\u4e3a\u4e0e\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u6539\u53d8\u76f8\u5173\uff0c\u5728\u6781\u8f7b\u5ea6\u81f3\u8f7b\u5ea6<\/span>AD<\/span>\u60a3\u8005\u4e2d\u53d1\u73b0\u80a0\u9053\u83cc\u7fa4\u7684\u4e30\u5bcc\u5ea6\u548c\u591a\u6837\u6027\u964d\u4f4e\uff0c\u539a\u58c1\u83cc\u95e8\uff1a\u62df\u6746\u83cc\u95e8\u6bd4\u7387\u53d1\u751f\u6539\u53d8\uff0c\u8fd9\u4e9b\u75c7\u72b6\u5728\u80a5\u80d6\u7684\u7814\u7a76\u4e2d\u5e7f\u6cdb\u5b58\u5728\uff0c\u56e0\u800c\u8868\u660e<\/span>AD<\/span>\u548c<\/span>2<\/span>\u578b\u7cd6\u5c3f\u75c5\uff08<\/span>T2DM<\/span>\uff09\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u8054\u7cfb\u3002\u4e0e\u8ba4\u77e5\u529f\u80fd\u6b63\u5e38\u7684\u8001\u5e74\u4eba\u76f8\u6bd4\uff0c<\/span>AD<\/span>\u60a3\u8005\u548c\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u8840\u6e05\u4e2d\u6b21\u7ea7\u80c6\u6c41\u9178\uff08\u7531\u80a0\u9053\u83cc\u7fa4\u4ece\u521d\u7ea7\u80c6\u6c41\u9178\u4ee3\u8c22\u800c\u6765\uff09\u7684\u6c34\u5e73\u51fa\u73b0\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u7684\u6539\u53d8\u4e0e\u8001\u5e74\u4eba\u7684\u8ba4\u77e5\u969c\u788d\u4ee5\u53ca\u6dc0\u7c89\u6837\u86cb\u767d<\/span>-\u03b2<\/span>\u8d1f\u8377\u76f8\u5173\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2.5 \u5176\u4ed6\u8111\u90e8\u75be\u75c5<\/span><\/strong><\/p>\n

\u5173\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u4e0e\u80a0\u9053\u83cc\u7fa4\u76f8\u5173\u7684\u7814\u7a76\u8f83\u5c11\uff0c\u4f46\u7cbe\u795e\u5206\u88c2\u75c7\u786e\u5b9e\u5b58\u5728\u80a0\u9053\u5408\u5e76\u75c7\u7684\u5e76\u53d1\u75c7\u3002\u4e5f\u6709\u8bc1\u636e\u521d\u6b65\u8868\u660e\uff0c\u767d\u8272\u5ff5\u73e0\u83cc\u7684\u5b58\u5728\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u7537\u6027\u60a3\u8005\u7cbe\u795e\u75c7\u72b6\u53d8\u5dee\u76f8\u5173\u3002\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u63cf\u8ff0\u4e86\u7279\u5b9a\u7684\u5206\u7c7b\u7fa4\uff0c\u5305\u62ec<\/span>Veillonellaceae<\/span><\/em>\u548c<\/span>Lachnospiraceae<\/span><\/em>\uff0c\u5b83\u4eec\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u4e25\u91cd\u7a0b\u5ea6\u76f8\u5173\u3002\u6b64\u5916\uff0c\u4ece\u8fd9\u4e9b\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u5230\u65e0\u83cc\u5c0f\u9f20\u7684\u7caa\u83cc\u79fb\u690d\u9664\u4e86\u6539\u53d8\u8c37\u6c28\u9178\u76d0\u4fe1\u53f7\u5916\uff0c\u8fd8\u5728\u52a8\u7269\u4e2d\u5f15\u8d77\u7cbe\u795e\u5206\u88c2\u75c7\u8868\u578b\u3002<\/span><\/p>\n

\u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\uff08<\/span>ASD<\/span>\uff09\u60a3\u8005\u7ecf\u5e38\u4e5f\u8868\u73b0\u51fa\u80a0\u9053\u76f8\u5173\u5408\u5e76\u75c7\u3002\u51e0\u9879\u7814\u7a76\u63cf\u8ff0\u4e86<\/span>ASD<\/span>\u513f\u7ae5\u80a0\u9053\u5fae\u751f\u7269\u8c31\u7684\u6539\u53d8\uff0c\u53d1\u73b0\u6709\u76ca\u83cc\uff08\u7279\u522b\u662f\u53cc\u6b67\u6746\u83cc\uff09\u4e30\u5ea6\u7684\u964d\u4f4e\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0\u4e86\u68ad\u72b6\u82bd\u5b62\u6746\u83cc\uff08\u4e00\u79cd\u6f5c\u5728\u81f4\u75c5\u83cc\u5c5e\uff09\u7684\u4e30\u5ea6\u589e\u52a0\u3002\u5728\u4e00\u9879\u77ed\u671f\u7814\u7a76\u4e2d\uff0c\u4e07\u53e4\u9709\u7d20\uff08\u4e00\u79cd\u5e7f\u8c31\u6297\u751f\u7d20\uff09\u6cbb\u7597\u5bfc\u81f4\u884c\u4e3a\u75c7\u72b6\u7684\u9633\u6027\u6539\u53d8\uff0c\u8fdb\u4e00\u6b65\u5f3a\u8c03\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7279\u5f81\u5f02\u5e38\u6539\u53d8\u5728<\/span>ASD<\/span>\u4e2d\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u5728\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u5c06\u5065\u5eb7\u4e2a\u4f53\u7684\u80a0\u9053\u5fae\u751f\u7269\u7eb3\u5165<\/span>ASD<\/span>\u60a3\u8005\uff0c\u53ef\u4f7f<\/span>ASD<\/span>\u60a3\u8005\u4e2d\u80a0\u9053\u5408\u5e76\u75c7\u548c\u884c\u4e3a\u5747\u5f97\u5230\u6539\u5584\u3002\u5728\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u5c06\u5065\u5eb7\u4e2a\u4f53\u7684\u80a0\u9053\u5fae\u751f\u7269\u7eb3\u5165<\/span>ASD<\/span>\u60a3\u8005\uff0c\u53ef\u4f7f<\/span>ASD<\/span>\u60a3\u8005\u4e2d\u80a0\u9053\u5408\u5e76\u75c7\u548c\u3002\u884c\u4e3a\u5747\u5f97\u5230\u6539\u5584<\/span><\/p>\n

 <\/span><\/p>\n

3 \u9488\u5bf9\u5fae\u751f\u7269-\u80a0\u9053-\u8111\u8f74\u7684\u6cbb\u7597<\/span><\/strong><\/p>\n

\u8003\u8651\u5230\u80a0\u9053\u83cc\u7fa4\u5728\u8fd9\u4e9b\u5927\u8111\u76f8\u5173\u75be\u75c5\u4e2d\u53d1\u6325\u4f5c\u7528\u7684\u65b0\u8bc1\u636e\uff0c\u90a3\u4e48\u901a\u8fc7\u6539\u53d8\u80a0\u9053\u83cc\u7fa4\u9776\u5411\u4ecb\u5bfc\u5927\u8111\u7684\u624b\u6bb5\u5c31\u4e0d\u8db3\u4e3a\u5947\u4e86\u3002\u201c\u7cbe\u795e\u751f\u7269\u8d28\u201d\u4e00\u8bcd\u7531<\/span>Dinan<\/span>\u7b49\u4eba\u4e8e<\/span>2013<\/span>\u5e74\u63d0\u51fa\uff0c\u662f\u4e00\u7c7b\u65b0\u578b\u7cbe\u795e\u836f\u7269\uff0c\u88ab\u5b9a\u4e49\u4e3a\u201c\u5f53\u6444\u5165\u8db3\u91cf\u65f6\uff0c\u5bf9\u7cbe\u795e\u75be\u75c5\u60a3\u8005\u4ea7\u751f\u5065\u5eb7\u83b7\u76ca\u7684\u6d3b\u751f\u7269\u4f53\u201d\u3002\u6b64\u540e\uff0c\u8be5\u5b9a\u4e49\u88ab\u6269\u5c55\u81f3\u5305\u62ec\u201c\u5bf9\u5927\u8111\u7684\u5f71\u54cd\u662f\u7ec6\u83cc\u4ecb\u5bfc\u7684\u4efb\u4f55\u5916\u6e90\u6027\u5f71\u54cd\u201d\u3002\u56e0\u6b64\uff0c\u5fc3\u7406\u751f\u7269\u5236\u5242\u53ef\u4ee5\u5305\u62ec\u4e00\u7cfb\u5217\u5f71\u54cd\u5fae\u751f\u7269<\/span>–<\/span>\u80a0\u8111\u8f74\u4fe1\u53f7\u7684\u7269\u8d28\uff0c\u5305\u62ec\u76ca\u751f\u83cc\u3001\u76ca\u751f\u5143\u3001\u5408\u751f\u5143\u548c\u540e\u751f\u5143\uff08\u56fe<\/span>2<\/span>\uff09\u3002\u8fd9\u4e9b\u7269\u8d28\u53ef\u4ee5\u901a\u8fc7\u8865\u5145\u5242\u3001\u529f\u80fd\u6027\u98df\u7269\u548c\u6539\u5584\u996e\u98df\u6444\u5165\u6765\u63d0\u4f9b\u3002<\/span><\/p>\n

 <\/span><\/p>\n

<\/p>\n

\u56fe<\/span>2 <\/span>\u6f5c\u5728\u7684\u5fc3\u7406\u751f\u7269\u5236\u5242\u3002\u5305\u62ec\u76ca\u751f\u83cc\u3001\u6d3b\u751f\u7269\u6cbb\u7597\u836f\u3001\u76ca\u751f\u5143\u3001\u5408\u751f\u5143\u3001\u526f\u76ca\u751f\u83cc\u3001\u76ca\u751f\u7d20\u3001\u53d1\u9175\u98df\u54c1\u7b49\u3002<\/span>
<\/p>\n

 <\/span><\/strong><\/p>\n

3.1 \u76ca\u751f\u83cc\uff1a\u6d3b\u751f\u7269\u6cbb\u7597\u836f\u7269<\/span><\/strong><\/p>\n

\u76ca\u751f\u83cc\u88ab\u5b9a\u4e49\u4e3a\u201c\u8db3\u91cf\u7ed9\u836f\u65f6\u5bf9\u5bbf\u4e3b\u5177\u6709\u5065\u5eb7\u76ca\u5904\u7684\u6d3b\u5fae\u751f\u7269\u201d\u3002\u73b0\u5728\u6709\u5927\u91cf\u7684\u7814\u7a76\u663e\u793a\u4e86\u591a\u79cd\u76ca\u751f\u83cc\u83cc\u682a\u5728\u6d88\u9664\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u7684\u5e94\u6fc0\u3001\u6291\u90c1\u548c\u7126\u8651\u6837\u884c\u4e3a\u65b9\u9762\u7684\u76ca\u5904\uff0c\u6b64\u5916\u8fd8\u6709\u5927\u91cf\u7684\u6210\u529f\u7684\u4eba\u7c7b\u7814\u7a76\u3002\u5e76\u4e0d\u662f\u6240\u6709\u7684\u76ca\u751f\u83cc\u90fd\u5177\u6709\u5927\u8111\u6709\u76ca\u7684\u4f5c\u7528\u3002\u76ca\u751f\u83cc\u4e00\u822c\u4e0d\u4f1a\u9a7b\u7559\u5728\u80a0\u9053\u4e2d\uff0c\u5373\u76ca\u751f\u83cc\u5236\u5242\u9700\u8981\u6bcf\u5929\u98df\u7528\u624d\u80fd\u7ef4\u6301\u79ef\u6781\u4f5c\u7528\u3002\u4e00\u822c\u800c\u8a00\uff0c\u76ca\u751f\u83cc\u662f\u98df\u54c1\u7684\u6210\u5206\u6216\u4f5c\u4e3a\u98df\u54c1\u8865\u5145\u5242\u9012\u9001\u3002\u65b0\u4e00\u4ee3\u76ca\u751f\u83cc\uff0c\u5305\u62ec\u5728\u7f8e\u56fd\u6b63\u5f0f\u8ba4\u5b9a\u4e3a\u6d3b\u751f\u7269\u6cbb\u7597\u836f\u7269\u7684\u76ca\u751f\u83cc\u548c\u6ca1\u6709\u4f7f\u7528\u53f2\u4f46\u53ef\u80fd\u6709\u5065\u5eb7\u76ca\u5904\u7684\u76ca\u751f\u83cc\uff0c\u53ef\u80fd\u901a\u8fc7\u66f4\u4f20\u7edf\u7684\u836f\u7269\u9014\u5f84\u800c\u4e0d\u662f\u901a\u8fc7\u98df\u7269\u9012\u9001\u9012\u9001\u53d1\u6325\u6709\u76ca\u4f5c\u7528\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3.1.1 \u7cbe\u795e\u75c5\u76f8\u5173\u7814\u7a76<\/span><\/strong><\/p>\n

\u5927\u91cf\u7814\u7a76\u8bc1\u660e\u76ca\u751f\u83cc\u5728\u6539\u5584\u60c5\u7eea\u548c\u6291\u90c1\u72b6\u6001\u65b9\u9762\u6709\u4e00\u5b9a\u7684\u7597\u6548\u3002\u5176\u4e2d\uff0c\u4f7f\u7528\u542b\u6709\u5e72\u916a\u4e73\u6746\u83cc\u7684\u996e\u6599\u6cbb\u7597\u53ef\u6539\u5584\u8001\u5e74\u4eba\u7684\u60c5\u7eea\u8bc4\u5206\uff0c\u5728\u57fa\u7ebf\u65f6\u60c5\u7eea\u8bc4\u5206\u6700\u4f4e\u7684\u53c2\u4e0e\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u83b7\u76ca\u6700\u5927\u3002\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8fdb\u4e00\u6b65\u63cf\u8ff0\u4e86\u690d\u7269\u4e73\u6746\u83cc\u5728\u538b\u529b\u4f46\u5176\u4ed6\u65b9\u9762\u5065\u5eb7\u7684\u6210\u4eba\u4e2d\u7684\u591a\u79cd\u76ca\u5904\uff0c\u5305\u62ec\u51cf\u8f7b\u538b\u529b\u548c\u7126\u8651\u63aa\u65bd\u4ee5\u53ca\u6539\u5584\u8bb0\u5fc6\u548c\u8ba4\u77e5\u7684\u591a\u4e2a\u65b9\u9762\uff0c\u589e\u5f3a<\/span>5-<\/span>\u7f9f\u8272\u80fa\u80fd\u4fe1\u53f7\uff0c\u4ee5\u53ca\u51cf\u5c11\u76ae\u8d28\u9187\u548c\u4fc3\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u3002\u5728\u4e00\u4e2a\u96be\u6cbb\u6027\u6291\u90c1\u75c7\u961f\u5217\u4e2d\uff0c\u76ca\u751f\u83cc\u4e5f\u88ab\u4f5c\u4e3a\u4e0e\u6297\u6291\u90c1\u836f\u7269\u8054\u5408\u4f7f\u7528\u7684\u6f5c\u5728\u8f85\u52a9\u6cbb\u7597\uff0c\u5728\u4e00\u9879\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u4e00\u5b9a\u7684\u5229\u7528\u524d\u666f\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u4e00\u4e9b\u7814\u7a76\u672a\u80fd\u663e\u793a\u8865\u5145\u76ca\u751f\u83cc\u5bf9<\/span>MDD<\/span>\u60a3\u8005\u5728\u6539\u5584\u6291\u90c1\u8bc4\u5206\u65b9\u9762\u7684\u4efb\u4f55\u76ca\u5904\uff0c\u8fd9\u8868\u660e\u5e76\u975e\u6240\u6709\u7684\u76ca\u751f\u83cc\u90fd\u5177\u6709\u6539\u5584\u7cbe\u795e\u75be\u75c5\u7684\u751f\u7269\u6d3b\u6027\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3.1.2 \u795e\u7ecf\u5b66\u76f8\u5173\u7814\u7a76<\/span><\/strong><\/p>\n

\u4f7f\u7528\u76ca\u751f\u83cc\u5e72\u9884\u8bd5\u56fe\u6539\u5584<\/span>AD<\/span>\u5bfc\u81f4\u7684\u4e00\u4e9b\u8ba4\u77e5\u7f3a\u9677\u7684\u7814\u7a76\u6570\u91cf\u6709\u9650\u3002\u5728\u4e00\u9879\u6b64\u7c7b<\/span>RCT<\/span>\u4e2d\uff0c\u5728\u4e73\u996e\u6599\u4e2d\u4f7f\u7528\u591a\u83cc\u682a\u76ca\u751f\u83cc\uff08\u55dc\u9178\u4e73\u6746\u83cc\u3001\u5e72\u916a\u4e73\u6746\u83cc\u3001\u53cc\u6b67\u6746\u83cc\u3001\u53d1\u9175\u4e73\u6746\u83cc\uff09\u5bfc\u81f4\u60a3\u8005\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\u8bc4\u5206\u6539\u5584\u3002\u7136\u800c\uff0c\u5728\u540c\u4e00\u7ec4\u7684\u53e6\u4e00\u9879<\/span>RCT<\/span>\u4e2d\uff0c\u4f7f\u7528\u5176\u4ed6\u4e73\u9178\u6746\u83cc\u548c\u53cc\u6b67\u6746\u83cc\u83cc\u682a\uff0c\u5728\u91cd\u5ea6<\/span>AD<\/span>\u961f\u5217\u4e2d\u672a\u89c2\u5bdf\u5230\u8ba4\u77e5\u6539\u5584\uff0c\u8fd9\u4e00\u7ed3\u679c\u518d\u6b21\u5f3a\u8c03\u4e86\u4e0d\u540c\u83cc\u682a\u5728\u6539\u5584\u75be\u75c5\u65b9\u9762\u7684\u5dee\u5f02\uff0c\u5e76\u5f3a\u8c03\u9700\u8981\u660e\u786e\u6cbb\u7597\u5e72\u9884\u75be\u75c5\u8fdb\u5c55\u7684\u6700\u4f73\u65f6\u95f4\u3002\u67d0\u4e9b\u76ca\u751f\u83cc\u83cc\u682a\u5728\u6539\u5584<\/span>ASD<\/span>\u4e34\u5e8a\u524d\u6a21\u578b\u7684\u884c\u4e3a\u548c\u795e\u7ecf\u5316\u5b66\u6270\u52a8\u65b9\u9762\u663e\u793a\u51fa\u5e0c\u671b\u3002\u4eba\u7c7b\u5bf9\u76ca\u751f\u83cc\u5728<\/span>ASD<\/span>\u4e2d\u5e94\u7528\u7684\u7814\u7a76\u5c1a\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u91cd\u70b9\u662f\u6539\u5584\u80a0\u9053\u76f8\u5173\u5408\u5e76\u75c7\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3.2 \u76ca\u751f\u5143<\/span><\/strong><\/p>\n

\u901a\u8fc7\u5c06\u6d3b\u7684\u5fae\u751f\u7269\u2014\u2014\u76ca\u751f\u83cc\u5f15\u5165\u7cfb\u7edf\uff0c\u8bd5\u56fe\u76f4\u63a5\u8c03\u8282\u80a0\u9053\u83cc\u7fa4\u5df2\u7ecf\u505a\u4e86\u5f88\u591a\u5de5\u4f5c\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5b58\u5728\u8bb8\u591a\u6280\u672f\u548c\u8fd0\u7528\u96be\u9898\u3002\u8fd9\u4e9b\u95ee\u9898\u5305\u62ec\u5982\u4f55\u786e\u4fdd\u76ca\u751f\u83cc\u5728<\/span>pH<\/span>\u6c34\u5e73\u6539\u53d8\u7684\u73af\u5883\u4e2d\u751f\u5b58\uff0c\u4ece\u80c3\u9178\u5230\u78b1\u6027\u80c6\u76d0\u73af\u5883\uff0c\u518d\u5230\u80a0\u9053\u4e2d\u80fd\u591f\u53d1\u6325\u6f5c\u5728\u6cbb\u7597\u4f5c\u7528\u7684\u4f4d\u7f6e\uff1b\u53d1\u9175\u7684\u96be\u6613\u7a0b\u5ea6\u4ee5\u53ca\u6279\u91cf\u751f\u4ea7\u7684\u8fde\u7eed\u6027\u548c\u4e00\u81f4\u6027\u95ee\u9898\u7b49\u3002\u53e6\u5916\uff0c\u9776\u5411\u6709\u76ca\u7684\u5bbf\u4e3b\u5fae\u751f\u7269\u7fa4\uff0c\u4fc3\u8fdb\u8fd9\u7c7b\u5fae\u751f\u7269\u7684\u5bcc\u96c6\u662f\u76ee\u524d\u6700\u5e38\u7528\u7684\u4e00\u79cd\u6cbb\u7597\u624b\u6bb5\u3002\u76ca\u751f\u5143\u88ab\u5b9a\u4e49\u4e3a\u201c\u88ab\u8d4b\u4e88\u5065\u5eb7\u76ca\u5904\u7684\u5bbf\u4e3b\u5fae\u751f\u7269\u9009\u62e9\u6027\u5229\u7528\u7684\u5e95\u7269\u201d\u3002\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u76ca\u751f\u5143\u7531\u83ca\u7c89\u3001\u4f4e\u805a\u679c\u7cd6\u3001\u4f4e\u805a\u534a\u4e73\u7cd6\uff08<\/span>GOSs<\/span>\uff09\u548c\u6297\u6027\u6dc0\u7c89\u7b49\u7ea4\u7ef4\u7ec4\u6210\uff0c\u8fd9\u4e9b\u7ea4\u7ef4\u5728\u5c0f\u80a0\u4e2d\u4e0d\u80fd\u88ab\u5438\u6536\uff0c\u88ab\u80a0\u9053\u5fae\u751f\u7269\u9009\u62e9\u6027\u53d1\u9175\u3002\u76ca\u751f\u5143\u5b58\u5728\u4e8e\u5404\u79cd\u5404\u6837\u7684\u6c34\u679c\u3001\u852c\u83dc\u548c\u8c37\u7269\u4e2d\u3002\u76ca\u751f\u5143\u4e5f\u5b58\u5728\u4e8e\u4eba\u4e73\u4e2d\uff08\u4eba\u4e73\u5be1\u7cd6\uff09\u3002\u4e0e\u4f7f\u7528\u5355\u83cc\u682a\u6216\u591a\u83cc\u682a\u76ca\u751f\u83cc\u76f8\u6bd4\uff0c\u4f7f\u7528\u76ca\u751f\u5143\u5e72\u9884\u7684\u4f18\u52bf\u5728\u4e8e\u53ef\u80fd\u80fd\u591f\u66f4\u5168\u9762\u5730\u6539\u5584\u80a0\u9053\u5fae\u751f\u7269\u72b6\u6001\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3.3 \u5408\u751f\u5143<\/span><\/strong><\/p>\n

\u5408\u751f\u5143\u662f\u76ca\u751f\u83cc\u548c\u76ca\u751f\u5143\u7684\u7ec4\u5408\uff0c\u7531\u4e8e\u76ca\u751f\u5143\u7684\u5f15\u5165\u8fdb\u800c\u63d0\u9ad8\u76ca\u751f\u83cc\u7684\u751f\u5b58\u80fd\u529b\uff0c\u53ef\u63d0\u4f9b\u53ef\u53d1\u9175\u7ea4\u7ef4\u7684\u6765\u6e90\u4ee5\u53ca\u4f5c\u4e3a\u4e00\u822c\u76ca\u751f\u5143\u3002\u5728\u8f7b\u5ea6\u81f3\u4e2d\u5ea6<\/span>MDD<\/span>\u4e2d\uff0c\u7531<\/span>GOS<\/span>\u548c\u53cc\u83cc\u682a\u76ca\u751f\u83cc\uff08<\/span>L. helveticus<\/span><\/em>\u548c<\/span>B. longum<\/span><\/em>\uff09\u7ec4\u6210\u7684\u5408\u751f\u5143\u5bfc\u81f4\u6291\u90c1\u8bc4\u5206\u964d\u4f4e\uff0c\u5e76\u5bf9\u8272\u6c28\u9178\u4fe1\u53f7\u4f20\u5bfc\u4ea7\u751f\u79ef\u6781\u5f71\u54cd\u3002\u6700\u8fd1\u7684\u4e00\u9879\u521d\u6b65\u7814\u7a76\u8868\u660e\uff0c\u4f7f\u7528\u5408\u751f\u5143\uff08\u5a74\u513f\u53cc\u6b67\u6746\u83cc\u52a0\u5be1\u7cd6\uff09\u5728\u6539\u5584\u4e00\u4e9b\u4e0e<\/span>ASD<\/span>\u76f8\u5173\u7684\u80a0\u9053\u76f8\u5173\u5408\u5e76\u75c7\u65b9\u9762\u5177\u6709\u4e00\u5b9a\u7684\u524d\u666f\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3.4 \u76ca\u751f\u7d20<\/span><\/strong><\/p>\n

\u76ca\u751f\u7d20\u662f\u4e00\u79cd\u975e\u6d3b\u6027\u5b9e\u4f53\uff0c\u662f\u7ec6\u83cc\u53d1\u9175\u7684\u4ee3\u8c22\u4ea7\u7269\uff0c\u5305\u62ec\u751f\u7269\u6d3b\u6027\u7269\u8d28\uff0c\u5982<\/span>SCFA<\/span>\u3002\u6700\u8fd1\u63cf\u8ff0\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u548c<\/span>SCFA<\/span>\u5bf9\u4ee3\u8c22\u7279\u5f81\u548c\u75be\u75c5\u7684\u5f71\u54cd\u3002\u5173\u4e8e\u8111\u5065\u5eb7\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u63cf\u8ff0\u4e86<\/span>SCFA<\/span>\u590d\u65b9\u5236\u5242\uff08\u918b\u9178\u76d0\u3001\u4e19\u9178\u76d0\u548c\u4e01\u9178\u76d0\u7684\u6df7\u5408\u7269\uff09\u7ed9\u4e88\u5fc3\u7406\u793e\u4f1a\u5e94\u6fc0\u5c0f\u9f20\u7684\u6297\u7126\u8651\u4f5c\u7528\u3002\u7ed9\u4e88\u5927\u9f20\u4e19\u9178\u53ef\u5bfc\u81f4\u5b64\u72ec\u75c7\u6837\u8868\u578b\u3002\u5728\u4e00\u9879\u4eba\u4f53\u5e72\u9884\u6027\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528\u83ca\u7c89<\/span>–<\/span>\u4e19\u9178\u916f\u53ef\u589e\u52a0\u7ed3\u80a0\u4e2d\u7684\u4e19\u9178\u76d0\u751f\u6210\uff0c\u8fdb\u884c\u8111\u6210\u50cf\u4ee5\u786e\u5b9a\u5bf9\u98df\u7269\u56fe\u7247\u8bc4\u4ef7\u4efb\u52a1\u7684\u53cd\u5e94\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5904\u7406\u7ec4\u7eb9\u72b6\u4f53\u4e2d\u7684\u9884\u671f\u5956\u8d4f\u53cd\u5e94\u51cf\u5c11\u3002\u56e0\u6b64\uff0c\u53ef\u4ee5\u901a\u8fc7\u8865\u5145\u6b64\u7c7b\u751f\u7269\u6d3b\u6027\u6765\u9488\u5bf9\u884c\u4e3a\u662f\u5408\u7406\u7684\u3002<\/span><\/p>\n

\u80a0\u9053\u80bd\u5728\u5f71\u54cd\u884c\u4e3a\u65b9\u9762\u5177\u6709\u660e\u786e\u7684\u4f5c\u7528\uff0c\u5728\u538b\u529b\u3001\u7126\u8651\u548c\u6291\u90c1\u4e2d\u4e5f\u5177\u6709\u4e00\u5b9a\u7684\u4f5c\u7528\u3002\u867d\u7136\u6280\u672f\u95ee\u9898\u53ef\u80fd\u963b\u788d\u76f4\u63a5\u4f7f\u7528\u80a0\u80bd\u4f5c\u4e3a\u80a0<\/span>–<\/span>\u8111\u8f74\u4fe1\u53f7\u7684\u5e72\u9884\uff0c\u4f46\u9776\u5411\u7279\u5b9a\u7684\u5fae\u751f\u7269\u7fa4\u4ee5\u4fbf\u8c03\u8282\u7279\u5b9a\u7684\u80a0\u80bd\u53ef\u80fd\u662f\u4e00\u79cd\u6709\u7528\u7684\u5fc3\u7406\u751f\u7269\u8d28\u7597\u6cd5\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3.5 \u53d1\u9175\u98df\u54c1<\/span><\/strong><\/p>\n

\u53d1\u9175\u98df\u54c1\u542b\u6709\u76ca\u751f\u83cc\u3001\u76ca\u751f\u5143\u548c\u7ec6\u83cc\u6765\u6e90\u7684\u751f\u7269\u6d3b\u6027\u7269\u8d28\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u53d1\u9175\u4e73\u996e\u6599\u5728\u60c5\u7eea\u5904\u7406\u548c\u538b\u529b\u65b9\u9762\u4f1a\u5e26\u6765\u79ef\u6781\u7684\u76ca\u5904\u3002<\/span><\/p>\n

\u4e00\u9879\u5728\u5973\u6027\u4e2d\u8fdb\u884c\u7684\u5927\u961f\u5217\u3001\u6a2a\u65ad\u9762\u7814\u7a76\u53d1\u73b0\uff0c\u66f4\u5065\u5eb7\u7684\u996e\u98df\u6a21\u5f0f\u4e0e\u66f4\u597d\u7684\u4e00\u822c\u5065\u5eb7\u8bc4\u5206\u76f8\u5173\uff0c\u5e76\u964d\u4f4e\u4e86\u7126\u8651\u548c\u6291\u90c1\u7ed3\u5c40\u7684\u53d1\u751f\u7387\u3002<\/span>22<\/span>\u9879\u7814\u7a76\u7684\u835f\u8403\u5206\u6790\u4e5f\u663e\u793a\uff0c\u968f\u7740\u5730\u4e2d\u6d77\u996e\u98df\u4f9d\u4ece\u6027\u7684\u589e\u52a0\uff0c\u6291\u90c1\u548c\u8ba4\u77e5\u969c\u788d\u7684\u98ce\u9669\u964d\u4f4e\uff0c\u5305\u62ec\u60a3<\/span>AD<\/span>\u7684\u98ce\u9669\u3002\u6700\u8fd1\u53d1\u8868\u7684\u4e00\u9879\u5bf9<\/span>14<\/span>\u9879\u89c2\u5bdf\u6027\u7814\u7a76\u7684\u835f\u8403\u5206\u6790\u63cf\u8ff0\u4e86\u6291\u90c1\u98ce\u9669\u4e0e\u575a\u6301\u5730\u4e2d\u6d77\u996e\u98df\u4e4b\u95f4\u65e0\u663e\u8457\u76f8\u5173\u6027\uff0c\u4f46\u5728\u4eba\u7fa4\u4e2d\u786e\u5b9e\u53d1\u73b0\u4e86\u4e0e\u6291\u90c1\u51e0\u7387\u7684\u76f8\u5173\u6027\u3002\u8fd9\u4ecd\u9700\u8981\u5bf9\u5bcc\u542b\u6f5c\u5728\u7cbe\u795e\u751f\u7269\u7684\u996e\u98df\u7684\u76ca\u5904\u8fdb\u884c\u66f4\u591a\u7684\u524d\u77bb\u6027\u996e\u98df\u7814\u7a76\uff0c\u4ee5\u5145\u5206\u9610\u660e\u5173\u4e8e\u538b\u529b\u3001\u7126\u8651\u548c\u6291\u90c1\u7ed3\u679c\u7684\u6f5c\u5728\u76ca\u5904\u3002\u663e\u7136\uff0c\u4eba\u4eec\u5bf9\u5229\u7528\u5065\u5eb7\u996e\u98df\u5bf9\u7cbe\u795e\u75c5\u4eba\u7fa4\u7684\u76ca\u5904\u8d8a\u6765\u8d8a\u611f\u5174\u8da3\u3002\u5730\u4e2d\u6d77\u996e\u98df\u5305\u62ec\u8bb8\u591a\u5bcc\u542b\u7cbe\u795e\u751f\u7269\u7684\u5143\u7d20\uff0c\u7279\u522b\u662f\u76ca\u751f\u5143\u3002\u8fd9\u79cd\u6dfb\u52a0\u53d1\u9175\u98df\u54c1\u548c\u540e\u751f\u5143\u7b49\u7269\u54c1\u7684\u996e\u98df\u7ec4\u5408\u5bf9\u5fae\u751f\u7269<\/span>–<\/span>\u80a0\u8111\u8f74\u4fe1\u53f7\u7684\u8c03\u8282\u6709\u76ca\u3002\u8fd9\u79cd\u996e\u98df\u5728\u51cf\u8f7b\u538b\u529b\u3001\u7126\u8651\u548c\u6291\u90c1\u75c7\u72b6\u65b9\u9762\u7684\u6f5c\u5728\u76ca\u5904\u503c\u5f97\u7814\u7a76\u3002<\/span><\/p>\n

 <\/span><\/p>\n

4 \u836f\u7269\u548c\u5fae\u751f\u7269\u4e92\u76f8\u5f71\u54cd<\/span><\/strong><\/p>\n

\u867d\u7136\u6297\u751f\u7d20\u6cbb\u7597\u5bf9\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u6709\u8f83\u5927\u7684\u5f71\u54cd\uff0c\u4f46\u6700\u8fd1\u7684\u591a\u9879\u7814\u7a76\u5f3a\u8c03\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7814\u7a76\u4e2d\u5176\u4ed6\u836f\u7269\u7684\u6f5c\u5728\u6df7\u6742\u6548\u5e94\u3002\u5c24\u5176\u662f\uff0c\u4e00\u9879\u5173\u4e8e<\/span>T2DM<\/span>\u7684\u7814\u7a76\u786e\u5b9a\uff0c\u4e8c\u7532\u53cc\u80cd\uff08\u4e00\u79cd\u5e38\u7528\u7684\u964d\u7cd6\u836f\u7269\uff09\u662f<\/span>T2DM<\/span>\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u7279\u5f81\u53d1\u751f\u5927\u90e8\u5206\u6539\u53d8\u7684\u539f\u56e0\u3002\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff08<\/span>PPI<\/span>\uff09\u5bf9\u80a0\u9053\u83cc\u7fa4\u7684\u5f71\u54cd\u5df2\u88ab\u5145\u5206\u63cf\u8ff0\u3002\u6b64\u5916\uff0c\u591a\u79cd\u975e\u6297\u751f\u7d20\u836f\u7269\u5df2\u88ab\u786e\u5b9a\u5177\u6709\u6297\u83cc\u7279\u6027\uff0c\u5305\u62ec\u51e0\u79cd\u7cbe\u795e\u836f\u7269\uff0c\u53ef\u80fd\u81f3\u5c11\u90e8\u5206\u901a\u8fc7\u6539\u53d8\u5fae\u751f\u7269\u7279\u5f81\u6216\u901a\u8fc7\u6fc0\u6d3b\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u4fe1\u53f7\u53d1\u6325\u5176\u6709\u76ca\u6216\u4e0d\u826f\u53cd\u5e94\u3002\u603b\u4f53\u800c\u8a00\uff0c\u5728\u4efb\u4f55\u5173\u4e8e\u836f\u7269\u5728\u4f53\u5185\u4f5c\u7528\u673a\u5236\u4ee5\u53ca\u4e0e\u6709\u76ca\u6216\u4e0d\u826f\u53cd\u5e94\u5173\u7cfb\u7684\u7814\u7a76\u4e2d\u90fd\u9700\u8981\u8003\u8651\u80a0\u9053\u83cc\u7fa4\u3002\u53ef\u4ee5\u5229\u7528\u80a0\u9053\u83cc\u7fa4\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u6216\u9650\u5236\u5176\u4ed6\u60c5\u51b5\u4e0b\u7684\u4ee3\u8c22\u526f\u4f5c\u7528\uff0c\u5982\u6297\u7cbe\u795e\u75c5\u836f\u7269\uff0c\u80a0\u9053\u83cc\u7fa4\u751a\u81f3\u53ef\u80fd\u662f\u67d0\u4e9b\u836f\u7269\u5728\u5176\u4ed6\u60c5\u51b5\u4e0b\u7597\u6548\u4e0b\u964d\u7684\u539f\u56e0\u3002<\/span><\/p>\n

 <\/span><\/p>\n

5 \u6f5c\u5728\u5fc3\u7406\u751f\u7269\u5236\u5242\u7684\u7b5b\u67e5<\/span><\/strong><\/p>\n

\u7b5b\u9009\u5fae\u751f\u7269\u7ec4\u4ee5\u9274\u5b9a\u5176\u662f\u5426\u53ef\u8c03\u8282\u795e\u7ecf\u7684\u4f20\u5bfc\u6d89\u53ca\u4e00\u4e2a\u4e0e\u4f20\u7edf\u836f\u7269\u7b5b\u9009\u975e\u5e38\u4e0d\u540c\u7684\u8fc7\u7a0b\uff08\u56fe<\/span>3<\/span>\uff09\u3002\u7b2c\u4e00\u6b65\u662f\u65b0\u9c9c\u7caa\u4fbf\u91c7\u6837\uff0c\u5c06\u6240\u5f97\u65b0\u9c9c\u7ec6\u83cc\u94fa\u677f\u4e8e\u7279\u5b9a\u743c\u8102\u57f9\u517b\u57fa\u4e2d\uff0c\u5e76\u6311\u53d6\u83cc\u843d\u3002\u7136\u540e\u4f7f\u7528\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u9274\u5b9a\u83cc\u682a\u3002\u867d\u7136\u67d0\u4e9b\u83cc\u5c5e\u7684\u83cc\u682a\u5df2\u7ecf\u88ab\u8ba4\u4e3a\u662f\u5b89\u5168\u7684\uff0c\u4f46\u5176\u4ed6\u65b0\u7684\u76ca\u751f\u83cc\u5728\u88ab\u6279\u51c6\u4f7f\u7528\u4e4b\u524d\u9700\u8981\u8fdb\u884c\u5e7f\u6cdb\u7684\u5206\u6790\u3002<\/span><\/p>\n

 <\/span><\/p>\n

<\/p>\n

\u56fe<\/span>3 <\/span>\u7b5b\u9009\u6f5c\u5728\u7684\u7cbe\u795e\u751f\u7269\u8d28\u6cbb\u7597\u3002\u4ece\u9274\u5b9a\u611f\u5174\u8da3\u7684\u83cc\u682a\u5f00\u59cb\uff0c\u7136\u540e\u8fdb\u884c\u4e00\u7ec4\u6d4b\u8bd5\uff0c\u4ee5\u786e\u5b9a\u662f\u5426\u5bf9\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u4fe1\u53f7\u6709\u79ef\u6781\u5f71\u54cd\u3002<\/span>
<\/p>\n

 <\/span><\/p>\n

\u4e00\u65e6\u9009\u62e9\u4e86\u83cc\u682a\uff0c\u9664\u4e86\u4f53\u5916\u7ec6\u80de\u8bd5\u9a8c\u5916\uff0c\u5b83\u4eec\u8fd8\u53ef\u7528\u4e8e\u4e00\u7ec4\u8bd5\u9a8c\uff0c\u5982\u9176\u8bd5\u9a8c\uff0c\u7531\u6b64\u5c06\u76ee\u6807\u7ec6\u80de\u4e0e\u4e0d\u540c\u6d53\u5ea6\u7684\u76ca\u751f\u83cc\u5019\u9009\u7269\u5171\u540c\u5b75\u80b2\u3002\u6839\u636e\u76ee\u6807\u7ec6\u80de\u7c7b\u578b\uff0c\u53ef\u76d1\u6d4b\u7ec6\u80de\u7684\u751f\u957f\u3001\u5f62\u6001\u548c\u6297\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u5176\u4ed6\u751f\u7269\u6d3b\u6027\uff08\u5982<\/span>SCFA<\/span>\u3001\u795e\u7ecf\u9012\u8d28\u548c\u6fc0\u7d20\uff09\u7684\u751f\u6210\u3002\u5982\u679c\u5019\u9009\u76ca\u751f\u83cc\u5728\u8fd9\u4e9b\u56e0\u7d20\u4e2d\u7684\u4efb\u4f55\u4e00\u4e2a\u65b9\u9762\u8868\u73b0\u51fa\u7279\u6b8a\u7684\u76ca\u5904\uff0c\u90a3\u4e48\u76ca\u751f\u83cc\u53ef\u4ee5\u7528\u4e8e\u4e34\u5e8a\u524d\u4f53\u5185\u6d4b\u8bd5\uff0c\u5e76\u53ef\u4ee5\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u5b89\u5168\u6027\u5206\u6790\u3002\u9700\u8981\u4ed4\u7ec6\u8003\u8651\u5e72\u9884\u7684\u65f6\u673a\u548c\u65b9\u5f0f\u3002\u901a\u5e38\u4f1a\u8fdb\u884c\u4e00\u7ec4\u8fdb\u4e00\u6b65\u7684\u884c\u4e3a\u6d4b\u8bd5\uff0c\u4ee5\u786e\u5b9a\u662f\u5426\u53ef\u4ee5\u9610\u660e\u4efb\u4f55\u6297\u7126\u8651\u6216\u6297\u6291\u90c1\u8868\u578b\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
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\n
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\u7ed3\u8bba<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5728\u5927\u91cf\u7684\u795e\u7ecf\u75be\u75c5\u4e2d\u89c2\u5bdf\u5230\u7684\u80a0\u9053\u83cc\u7fa4\u6539\u53d8\u53ef\u80fd\u5728\u75c7\u72b6\u8868\u8fbe\u4e2d\u8d77\u56e0\u679c\u4f5c\u7528\uff0c\u5e76\u4e14\u7528\u4e8e\u6cbb\u7597\u8fd9\u4e9b\u75be\u75c5\u7684\u8bb8\u591a\u836f\u7269\u53ef\u80fd\u5bf9\u6211\u4eec\u7684\u80a0\u9053\u5fae\u751f\u7269\u7684\u591a\u6837\u6027\u6709\u76ca\u6216\u6709\u5bb3\uff0c\u8fd9\u4f7f\u5f97\u6211\u4eec\u5728\u7814\u53d1\u3001\u8bc4\u4ef7\u548c\u9009\u62e9\u836f\u7269\u6cbb\u7597\u75be\u75c5\u65f6\u8003\u8651\u66f4\u591a\u7684\u65b9\u9762\u3002\u6b64\u5916\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\u80a0\u9053\u5fae\u751f\u7269\u4e2d\u542b\u6709\u5927\u91cf\u53ef\u6539\u5584\u5bbf\u4e3b\u7cbe\u795e\u72b6\u6001\u7684\u83cc\u682a\uff0c\u90a3\u4e48\u5bf9\u4e8e\u5176\u662f\u5426\u53ef\u4f5c\u4e3a\u76ca\u751f\u83cc\u7684\u7814\u7a76\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u5b8c\u5584\u3002\u5f53\u7136\uff0c\u76f4\u63a5\u9776\u5411\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u662f\u65b0\u4e00\u4ee3\u6cbb\u7597\u7684\u4e00\u4e2a\u597d\u7684\u9009\u62e9\u3002\u5fae\u751f\u7269<\/span>–<\/span>\u80a0<\/span>–<\/span>\u8111\u8f74\u4fe1\u53f7\u7684\u9776\u5411\u6539\u53d8\u4e3a\u8bb8\u591a\u5fc3\u7406\u548c\u7cbe\u795e\u75be\u75c5\u8f85\u52a9\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6cbb\u7597\u673a\u4f1a\u3002\u6316\u6398\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u4e2d\u6f5c\u5728\u7684\u5fc3\u7406\u751f\u7269\u5236\u5242\u53ef\u80fd\u4e3a\u5f00\u53d1\u8fd9\u4e9b\u65b0\u7684\u5e72\u9884\u63aa\u65bd\u94fa\u5e73\u9053\u8def\u3002<\/span><\/section>\n


<\/p>\n


<\/p>\n

<\/span><\/p>\n

\u5f80\u671f\u6587\u7ae0\u63a8\u8350<\/strong><\/span><\/p>\n

\u764c\u7ec6\u80de\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff1a\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u5173\u952e<\/a><\/span>
<\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

BD Accuri C5\u6d41\u5f0f\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

BD FACSJAZZ\u6d41\u5f0f\u7ec6\u80de\u5206\u9009\u4eea\u57fa\u672c\u53c2\u6570\u53ca\u5e94\u7528\u7b80\u4ecb<\/a>
<\/p>\n

BD Accuri C5\u6d41\u5f0f\u7ec6\u80de\u4eea\u4f7f\u7528\u89c4\u8303\u53ca\u64cd\u4f5c\u6d41\u7a0b<\/a>
<\/p>\n

\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/p>\n

WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

ZESS Axio Observer3\u5012\u7f6e\u8367\u5149\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
<\/p>\n

Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
<\/p>\n

\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a>
<\/p>\n

PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a>
<\/p>\n

\u5982\u4f55\u6d4b\u91cfWestern Blot\u6761\u5e26\u7070\u5ea6\u503c\uff1f(GelPro\u8f6f\u4ef6\u4f7f\u7528\u65b9\u6cd5)<\/a>
<\/p>\n

\u5b9e\u9a8c\u4e2d\u5982\u4f55\u6311\u9009\u5230\u4e00\u652f\u597d\u7528\u7684\u6297\u4f53\uff1f<\/span><\/a>
<\/p>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


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\u5173\u6ce8\u672c\u53f7\u56de\u590d201117\u5373\u53ef\u83b7\u53d6pdf\u539f\u6587~<\/span><\/p>\n


<\/p>\n

\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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