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\u8fd1\u5e74\u6765\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/strong><\/span>\uff08CIT\uff09<\/span>\u7684\u6cbb\u7597\u8fdb\u5c55\u8fc5\u901f\uff0c\u53cd\u6620\u51fa\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u4e0e\u80bf\u7624\u76f8\u4e92\u4f5c\u7528\u7684\u91cd\u8981\u6027\u3002\u5c3d\u7ba1CIT\u5728\u5e7f\u6cdb\u7684\u4eba\u7c7b\u80bf\u7624\u4e2d\u5f97\u5230\u4e86\u6210\u529f\u7684\u5e94\u7528\uff0c\u4f46\u53ea\u6709\u5c11\u6570\u665a\u671f\u80bf\u7624\u60a3\u8005\u901a\u8fc7\u8fd9\u4e9b\u6cbb\u7597\u5f97\u5230\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5e94\u7b54\u548c\u751f\u5b58\u3002<\/span>
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2020\u5e74\u521d\uff0c<\/span> Immunity <\/strong><\/em><\/span>\u4e0a\u7684\u4e00\u7bc7\u6587\u7ae0\uff0c\u5217\u4e3e\u4e86<\/span>\u76ee\u524d\u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/strong><\/span><\/span><\/strong>\uff08CIT\uff09<\/span>\u9762\u4e34\u7684\u5341\u5927\u6311\u6218<\/strong><\/span>\u3002\u5e94\u5bf9\u8fd9\u4e9b\u6311\u6218\u9700\u8981\u57fa\u7840\u79d1\u7814\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u5e08\u7684\u5171\u540c\u52aa\u529b\uff0c\u52a0\u901f\u4e86\u89e3\u80bf\u7624\u4e0e\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u590d\u6742\u5173\u7cfb\uff0c\u4ece\u800c\u4e3a\u80bf\u7624\u60a3\u8005\u5f00\u53d1\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/span>
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\u53e6\u5916\u7684\u6311\u6218\u6765\u81ea\u4e8e\u514d\u75ab\u7cfb\u7edf\u672c\u8eab\u7684\u590d\u6742\u6027\uff0c\u5b83\u4f9d\u8d56\u4e8e\u80bf\u7624\u5fae\u73af\u5883(TME)\u4e2d\u4f17\u591a\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u6765\u53d1\u6325\u529f\u80fd\uff0c\u56e0\u800c\u4e0d\u80fd\u5728\u5355\u4e00\u7ec6\u80de\u7c7b\u578b\u4e2d\u8f7b\u6613\u590d\u5236\u3002\u5176\u4e2d\u4e00\u4e9b\u590d\u6742\u6027\u53cd\u6620\u5728\u514d\u75ab\u6d78\u6da6\u4e2d\uff0c\u4eba\u4f53\u80bf\u7624\u53ef\u4ee5\u6392\u5217\u5728\u80bf\u7624\u514d\u75ab\u8fde\u7eed\u4f53\u4e0a\uff0c\u5e76\u6839\u636e\u514d\u75ab\u7ec6\u80de\u76f8\u5bf9\u4e8e\u80bf\u7624\u7684\u7a7a\u95f4\u5b9a\u4f4d\u548c\u95f4\u8d28\u533a\u5206\u5212\u5206\u4e3a\u708e\u6027\u3001\u514d\u75ab\u6c99\u6f20\u578b\u6216\u514d\u75ab\u6392\u65a5\u578b\u3002<\/span><\/section>\n

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\u6311\u6218\u4e8c\uff1a\u80bf\u7624\u514d\u75ab\u7684\u4e3b\u52a8\u9a71\u5bfc<\/span><\/strong><\/section>\n

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\u56fe1. \u80bf\u7624\u514d\u75ab\u8fde\u7eed\u4f53<\/span>
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\u603b\u4f53\u7684\u4e34\u5e8a\u6311\u6218\u4ecd\u7136\u662f\u786e\u5b9a\u708e\u6027\u80bf\u7624\u6216\u9ad8\u6297\u539f\u8d1f\u8377\u80bf\u7624\u7684\u9608\u503c\uff0c\u4ee5\u53ca\u786e\u5b9a\u4e0e\u7279\u5b9a\u8868\u578b\u76f8\u5173\u7684\u7279\u5f02\u6027\u9a71\u52a8\u56e0\u7d20\u3002\u708e\u6027\u80bf\u7624TMB\u7684\u4e34\u754c\u503c\u53ef\u80fd\u4e0e\u975e\u708e\u6027\u80bf\u7624\u4e2dTMB\u7684\u4e34\u754c\u503c\u4e0d\u540c\u3002\u8054\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u8f6c\u5316\u9700\u8981\u786e\u5b9a\u5408\u9002\u7684\u60a3\u8005\u7fa4\u4f53\uff0c\u4ee5\u5c06\u6c99\u6f20\u578b\u6216\u6392\u65a5\u578b\u80bf\u7624\u8f6c\u5316\u4e3a\u708e\u6027\u80bf\u7624\u3002\u91c7\u7528\u9664<\/span>\uff08IHC\uff09<\/span>CD8\u68c0\u6d4b\u5916\u7684\u590d\u6742\u751f\u7269\u6807\u8bb0<\/span>\uff08\u5982TGF\u03b2\u3001\u9ad3\u7cfb\u751f\u7269\u5b66\u6216WNT\/\u03b2-catenin\u6216\u6539\u53d8\u7684\u80bf\u7624\u4ee3\u8c22\uff09<\/span>\u6709\u53ef\u80fd\u5f00\u53d1\u65b0\u7684\u57fa\u56e0\u6807\u7b7e\u3002<\/span><\/section>\n<\/section>\n
\n
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<\/section>\n
\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u7684\u4e3b\u5bfc\u529b\u91cf\u5305\u62ec\u80bf\u7624\u7ec6\u80de\u7684\u5185\u5728\u7279\u6027\u548c\u80bf\u7624\u6240\u5728\u7684\u5668\u5b98\u3002\u5728\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u4e2d\uff0c\u8f6c\u79fb\u5230\u809d\u810f\u7684\u80bf\u7624\u66f4\u6709\u53ef\u80fd\u5bf9\u6cbb\u7597\u8010\u836f\uff0c\u800c\u8f6c\u79fb\u5230\u6dcb\u5df4\u7ed3\u7684\u80bf\u7624\u66f4\u53ef\u80fd\u5bf9CPI\u4ea7\u751f\u5b8c\u5168\u5e94\u7b54\u3002\u56e0\u6b64\uff0c\u90e8\u4f4d\u662f\u4e0e\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u76f8\u5173\u65b9\u5f0f\u7684\u4e00\u4e2a\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002<\/span>
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\u5728\u80bf\u7624\u514d\u75ab\u5b66\u4e2d\uff0c\u7279\u522b\u662f\u4e0e\u6297\u80bf\u7624\u53cd\u5e94\u76f8\u5173\uff0c\u9700\u8981\u66f4\u591a\u5730\u8003\u8651\u4e0d\u540c\u7ec4\u7ec7\u4e2d\u7684\u514d\u75ab\u7ec4\u5206\u548c\u8981\u7d20\u3002\u4f8b\u5982\uff0c\u809d\u810f\u901a\u8fc7\u5404\u79cd\u673a\u5236\u4e0e\u8bf1\u5bfc\u514d\u75ab\u8010\u53d7\u6709\u5173\u3002\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\u3001Kupffer\u7ec6\u80de\u548c\u809d\u6811\u7a81\u72b6\u7ec6\u80de\u4e3b\u8981\u4fc3\u8fdb\u6d3b\u5316\u7684\u514d\u75ab\u6291\u5236\u901a\u8def\u7f51\u7edc\uff0c\u6291\u5236CD8+\u548cCD4+\u6548\u5e94T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002\u5bf9\u809d\u8f6c\u79fb\u7684\u53cd\u5e94\u8bc1\u660e\u4e86\u8fd9\u4e9b\u8010\u53d7\u6027\u673a\u5236\u5728\u80bf\u7624\u4e2d\u7684\u76f8\u5173\u6027\u3002\u6709\u809d\u8f6c\u79fb\u7684\u9ed1\u8272\u7d20\u7624\u6216NSCLC\u60a3\u8005\u5bf9pembrolizumab\u7684\u5e94\u7b54\u964d\u4f4e\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f<\/span>\uff08PFS\uff09<\/span>\u8f83\u77ed\uff0c\u8fd9\u4e0e\u8fb9\u7f18CD8+T\u7ec6\u80de\u6d78\u6da6\u51cf\u5c11\u6709\u5173\uff0c\u5bfc\u81f4\u514d\u75ab\u7cfb\u7edf\u65e0\u6cd5\u6709\u6548\u8fc1\u79fb\u5230\u764c\u7ec6\u80de\u3001\u8bc6\u522b\u764c\u7ec6\u80de\u548c\u6740\u4f24\u764c\u7ec6\u80de\u3002\u809d\u810f\u4e5f\u662f\u4e00\u4e2a\u9ad8\u5ea6\u8840\u7ba1\u5316\u7684\u5668\u5b98\uff0c\u7531MDSCs\u548c\u809d\u661f\u72b6\u7ec6\u80de\u6784\u6210\u809d\u810f\u7684\u7ed3\u6784\u3002\u8fd9\u4e9b\u4e0e\u809d\u810f\u4e2d\u7684\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e00\u8d77\uff0c\u4e3a\u5e38\u9a7bT\u7ec6\u80de\u6709\u6548\u6fc0\u6d3b\u5e76\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u63d0\u4f9b\u4e86\u4e00\u4e2a\u9ad8\u9608\u503c\u3002<\/span><\/section>\n

<\/section>\n
\u809d\u7ec6\u80de\u764c\u662f\u901a\u8fc7\u7531\u4e19\u578b\u809d\u708e\u6216\u4e59\u578b\u809d\u708e\u611f\u67d3\u5bfc\u81f4\u809d\u786c\u5316\uff0c\u5f15\u8d77\u6162\u6027\u809d\u75c5\u7684\u4e00\u79cd\u75be\u75c5\uff0c\u8054\u5408\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50<\/span>\uff08VEGF\uff09<\/span>\u9776\u5411\u6cbb\u7597\uff0c\u76ee\u524d\u5df2\u663e\u793a\u51fa\u5bf9CPI\u7684\u826f\u597d\u53cd\u5e94\u3002VEGF-\u9776\u5411\u6cbb\u7597\u5728\u9006\u8f6c\u4e0d\u53ef\u5207\u9664\u7684\u80be\u7ec6\u80de\u764c\u4e2d\u7684\u9ad3\u7cfb\u708e\u75c7\u4e2d\u7684\u4f5c\u7528\uff0c\u9664\u4e86\u4f7f\u80bf\u7624\u8840\u7ba1\u7cfb\u7edf\u6b63\u5e38\u5316\u5916\uff0c\u8fd8\u5047\u8bbe\u6709\u4e0e\u8fd9\u4e9b\u7597\u6cd5\u53ef\u4ee5\u4ea7\u751f\u534f\u540c\u3002\u8fd9\u4e9b\u8054\u5408\u7597\u6cd5\u662f\u5426\u80fd\u6709\u6548\u6cbb\u7597\u5176\u4ed6\u90e8\u4f4d\u80bf\u7624\u7684\u809d\u8f6c\u79fb\uff0c\u8fd8\u6709\u5f85\u89c2\u5bdf\u3002<\/span><\/section>\n

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\u76ee\u524d\u7684\u4e34\u5e8a\u6cbb\u7597\u6a21\u5f0f\u901a\u5e38\u4e0d\u5305\u62ec\u5668\u5b98\u7279\u5f02\u6027\u6cbb\u7597\u65b9\u6cd5\u3002\u5668\u5b98\u7279\u5f02\u6027\u514d\u75ab\u4e0d\u5c40\u9650\u4e8e\u809d\u810f\u3002\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u5728\u9aa8\u5fae\u73af\u5883\u4e2d\u4e5f\u7279\u522b\u6709\u9650\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u72ec\u7279\u7684\u57fa\u8d28\u76f8\u4e92\u4f5c\u7528<\/span>\uff08\u5982\u80f6\u539f\u86cb\u767d\uff09<\/span>\u3001\u5b58\u5728\u7684\u7ec6\u80de\u56e0\u5b50<\/span>\uff08\u5982TGF\u03b2\uff09<\/span>\u548cMDSC\u7684\u589e\u52a0\u3002\u6b64\u5916\uff0c\u6dcb\u5df4\u7ed3\u3001\u80ba\u548c\u76ae\u80a4\u7b49\u90e8\u4f4d\u901a\u5e38\u53ef\u80fd\u662f\u66f4\u6709\u5229\u7684\u6297\u80bf\u7624\u514d\u75ab\u90e8\u4f4d\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u8fd9\u4e9b\u7279\u5b9a\u5668\u5b98\u4e2d\u5b58\u5728\u76f8\u5bf9\u8f83\u9ad8\u7684\u514d\u75ab\u7ec6\u80de\u3002\u6700\u8fd1\u7684\u6570\u636e\u663e\u793a\u53ef\u4ee5\u91c7\u53d6\u5668\u5b98\u7279\u5f02\u6027\u6cbb\u7597\u65b9\u6cd5\uff0c\u5e76\u4e14\u8054\u5408\u6cbb\u7597\u7684\u5176\u4ed6\u7814\u7a76\u53ef\u4ee5\u9610\u660e\u514d\u75ab\u673a\u5236\u5339\u914d\u6cbb\u7597\u60a3\u8005\u7684\u5177\u4f53\u76ca\u5904\u3002<\/span><\/section>\n<\/section>\n
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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u7814\u7a76\u7ee7\u53d1\u6027\u9003\u9038\u7684\u9a71\u52a8\u56e0\u7d20\u66f4\u5177\u6311\u6218\u6027\uff0c\u4e3b\u8981\u662f\u7531\u4e8e\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u548c\u6cbb\u7597\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u7f3a\u4e4f\u7cfb\u7edf\u7684\u80bf\u7624\u7ec4\u7ec7\u6536\u96c6\u3002\u80bf\u7624\u53ef\u8bf1\u5bfc\u6297\u539f\u5448\u9012\u673a\u5236\u4e2d\u7684\u57fa\u56e0\u53d8\u5316\uff0c\u5305\u62ecJAK-STAT\u4fe1\u53f7\u7684\u7a81\u53d8\u3001\u03b22\u5fae\u7403\u86cb\u767d\u7684\u4e22\u5931\u3001MHC\u8868\u8fbe\u7684\u4e0b\u8c03\u3001\u514d\u75ab\u539f\u6027\u7a81\u53d8\u7684\u4e22\u5931\u6216\u6297\u539f\u4e22\u5931\uff0c\u4ee5\u514b\u670d\u514d\u75ab\u538b\u529b\u3002<\/span><\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
PD-L1\/PD-1\u6291\u5236\u5242\u7684\u53d1\u5c55\u4f7f\u8bb8\u591a\u60a3\u8005\u4ea7\u751f\u4e86\u9ad8\u6548\u7684\u5185\u6e90\u6027\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u4ee5\u6d88\u9664\u764c\u7ec6\u80de\u3002\u8fd9\u79cd\u5185\u6e90\u6027\u514d\u75ab\u53cd\u5e94\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8d56\u4e8e\u5148\u524d\u542f\u52a8\u7684CD8+T\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u80fd\u7279\u5f02\u6027\u8bc6\u522b\u764c\u7ec6\u80de\u3002\u901a\u8fc7\u6291\u5236PD-L1\/PD-1\uff0c\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u53ef\u4ee5\u88ab\u91cd\u65b0\u6fc0\u6d3b\u6216\u6269\u589e\uff0c\u4ece\u800c\u8bc6\u522b\u548c\u6740\u6b7b\u764c\u7ec6\u80de\u3002<\/span><\/section>\n

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\u5408\u6210\u514d\u75ab\u6cbb\u7597\u4e0e\u7edd\u5927\u591a\u6570\u5185\u6e90\u6027\u514d\u75ab\u53cd\u5e94\u76f8\u6bd4\uff0c\uff0c\u5982CAR T\u548cT\u7ec6\u80de\u7ed3\u5408\u6297\u4f53\u4f1a\u5bfc\u81f4\u9ad8\u5ea6\u6025\u6027\u6bd2\u6027\uff0c\u6700\u5e38\u89c1\u7684\u8868\u73b0\u4e3aCRS\u3002\u65e9\u671f\u8bc6\u522bCRS\u548c\u79ef\u6781\u4f7f\u7528\u7c7b\u56fa\u9187\u5bf9\u9884\u96325\u7ea7\u4e8b\u4ef6\u5f88\u91cd\u8981\u3002\u7c7b\u56fa\u9187\u7528\u4e8e\u6cbb\u7597CRS\u4f3c\u4e4e\u4e0d\u4f1a\u660e\u663e\u5f71\u54cd\u5408\u6210\u514d\u75ab\u6240\u4ea7\u751f\u7684\u7597\u6548\u3002\u7136\u800c\uff0c\u7c7b\u56fa\u9187\u7684\u4f7f\u7528\u4e0e\u8fdc\u671f\u7ed3\u5c40<\/span>\uff08\u5982\u591a\u5e74\u7684\u6301\u4e45\u751f\u5b58\uff09<\/span>\u4e4b\u95f4\u7684\u5173\u7cfb\u5c1a\u4e0d\u6e05\u695a\u3002\u867d\u7136\u4e86\u89e3\u514d\u75ab\u6bd2\u6027\u7684\u673a\u5236\u5e76\u4f18\u5316\u5904\u7406\u8fd9\u4e9b\u6bd2\u6027\u7684\u65b9\u6cd5\u662f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5b66\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u4e00\u4e2a\u66f4\u91cd\u8981\u7684\u6311\u6218\u662f\u5982\u4f55\u5f00\u53d1\u51fa\u66f4\u6709\u6548\u548c\u7279\u5f02\u7684CIT\uff0c\u8fd9\u4e9bCIT\u80fd\u591f\u5728\u4e0d\u4ea7\u751f\u81ea\u8eab\u514d\u75ab\u6216\u514d\u75ab\u4ecb\u5bfc\u6bd2\u6027\u7684\u60c5\u51b5\u4e0b\u6d88\u9664\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/section>\n<\/section>\n
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\u6311\u6218\u516b\uff1a\u901a\u8fc7\u590d\u5408\u751f\u7269\u6807\u8bb0\u6700\u4f18\u5316\u4e2a\u4f53\u5316\u6cbb\u7597<\/span><\/strong><\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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CIT\u7684\u751f\u7269\u6807\u8bb0\u7269\u5f00\u53d1\u5b58\u5728\u6311\u6218\u3002\u4e0e\u9776\u5411\u6cbb\u7597\u4e0d\u540c\uff0c\u9776\u5411\u6cbb\u7597\u901a\u5e38\u662f\u9776\u70b9\u81ea\u8eab\u7684\u57fa\u56e0\u5f02\u5e38<\/span>\uff08\u4f8b\u5982Her2\u6269\u589e\u3001EGFR\u7a81\u53d8\u3001ALK\u6613\u4f4d\uff09<\/span>\uff0c\u540e\u8005\u901a\u5e38\u88ab\u5b9a\u4e49\u4e3a\u4e8c\u5143<\/span>\uff08\u662f\u6216\u5426\uff09<\/span>\u68c0\u6d4b\uff0cCIT\u4e2d\u7684\u751f\u7269\u6807\u5fd7\u7269\u901a\u5e38\u9762\u4e34\u5173\u8054\u5ea6\u548c\u8fde\u7eed\u53d8\u91cf\u7684\u95ee\u9898\uff0cPD-L1\u8868\u8fbe\u3001TMB\u548c\u80bf\u7624\u6e90\u6027IFN\u03b3\u57fa\u56e0\u6807\u7b7e\u90fd\u662f\u5982\u6b64\uff0c\u6bcf\u79cd\u5728\u4e0d\u540c\u9002\u5e94\u75c7\u90fd\u6709\u591a\u4e2a\u4e0d\u540c\u7684\u751f\u7269\u6807\u8bb0\u7269\u4e34\u754c\u503c\u3002\u8fd9\u901a\u5e38\u4f7f\u5f97\u5728\u8bbe\u8ba1\u4e34\u5e8a\u8bd5\u9a8c\u65f6\uff0c\u9884\u5148\u786e\u5b9a\u751f\u7269\u6807\u5fd7\u7269\u7684\u4e34\u754c\u503c\u53bb\u533a\u5206\u9ad8\u6216\u4f4e\u503c\u4eba\u7fa4\u5177\u6709\u6311\u6218\u3002\u7ed8\u5236\u53d7\u8bd5\u8005\u5de5\u4f5c\u7279\u5f81<\/span>\uff08ROC\uff09<\/span>\u66f2\u7ebf\u7684\u7edf\u8ba1\u65b9\u6cd5\u53ef\u80fd\u6709\u7528\u3002\u5927\u578b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u7528\u4ee5\u786e\u5b9a\u751f\u7269\u6807\u5fd7\u7269\u57283\u671f\u8bd5\u9a8c\u7684\u4e34\u754c\u503c\uff0c\u5e76\u53ef\u80fd\u6709\u52a9\u4e8e\u4e3a\u80bf\u7624\u60a3\u8005\u8bca\u65ad\u662f\u5426\u4ece\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u5bf9\u751f\u7269\u6807\u5fd7\u7269\u5047\u8bf4\u7528\u7edf\u8ba1\u5b66\u7684\u4e25\u8c28\u6027\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5373\u4f7f\u662f\u56de\u987e\u6027\u5730\u8fdb\u884c\uff0c\u4e5f\u53ef\u80fd\u4fc3\u8fdb\u6cbb\u7597\u7b97\u6cd5\u7684\u53d1\u5c55\u3002<\/span><\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
PD-L1\/PD-1\u6291\u5236\u5242\u7684\u4f20\u7edf\u7edf\u8ba1\u548c\u6279\u51c6\u7684\u76d1\u7ba1\u7ec8\u70b9\u662f\u53ef\u7528\u7684\uff0c\u4f7f\u8bb8\u591a\u6b64\u7c7b\u836f\u7269\u80fd\u591f\u5feb\u901f\u548c\u5e7f\u6cdb\u7684\u8bc4\u4f30\u548c\u6279\u51c6\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7ec8\u70b9\uff0c\u5305\u62ecORR\u3001PFS\u548cOS\uff0c\u5e76\u6ca1\u6709\u88ab\u8bbe\u8ba1\u6216\u5f88\u597d\u5730\u5339\u914d\u7528\u4e8eCIT\u7684\u8bc4\u4f30\u3002\u5927\u591a\u6570\u8f6c\u79fb\u6027\u80bf\u7624\u60a3\u8005\u53ca\u5176\u6cbb\u7597\u533b\u5e08\u7684\u76ee\u6807\u662f\u5b9e\u73b0CIT\u7684\u6301\u4e45\u7597\u6548\u548c\u751f\u5b58\u7387\u3002\u5728\u68c0\u67e5Kaplan-Meier\u751f\u5b58\u66f2\u7ebf\u65f6\uff0c\u6700\u597d\u7528\u201c\u66f2\u7ebf\u5c3e\u90e8\u201d\u6765\u8861\u91cf\u8fd9\u4e00\u70b9\u3002\u7136\u800c\uff0c\u5206\u6790\u52a8\u529b\u4e0d\u8db3\uff0c\u9700\u8981\u957f\u671f\u968f\u8bbf\uff0c\u901a\u5e38\u6301\u7eed\u6570\u5e74\u4f7f\u5f97\u76ee\u524d\u7f3a\u4e4f\u8861\u91cf\u8fd9\u4e00\u76ca\u5904\u7684\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6cd5\u3002<\/span><\/section>\n

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\u8bba\u6587\u94fe\u63a5\uff1a<\/span><\/strong><\/span><\/section>\n
https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(19)30530-8<\/span><\/section>\n

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\u2014 THE  END \u2014<\/span><\/p>\n


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\u7248\u6743\u58f0\u660e\uff1a<\/span><\/strong><\/span>\u672c\u6587\u8f6c\u81ea\u201c Bio\u751f\u7269\u4e16\u754c\u201d\uff08<\/span>ibioworld<\/span>\uff09\uff0c\u7248\u6743\u5f52<\/span><\/span>\u539f\u4f5c\u8005\u6240\u6709\uff0c\u5982\u6709\u4fb5\u6743\uff0c\u8bf7\u8054\u7cfb\u672c\u516c\u4f17\u53f7\u7acb\u5373\u5220\u9664<\/span><\/span>\u3002<\/span><\/span><\/section>\n


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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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