{"id":3442,"date":"2021-02-15T13:09:00","date_gmt":"2021-02-15T05:09:00","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2021\/02\/15\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac7%e7%ab%a0%ef%bc%9at%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93tcr%e6%a6%82%e8%bf%b0\/"},"modified":"2021-02-15T13:09:00","modified_gmt":"2021-02-15T05:09:00","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac7%e7%ab%a0%ef%bc%9at%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93tcr%e6%a6%82%e8%bf%b0","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2021\/02\/15\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac7%e7%ab%a0%ef%bc%9at%e7%bb%86%e8%83%9e%e5%8f%97%e4%bd%93tcr%e6%a6%82%e8%bf%b0\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0"},"content":{"rendered":"
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\u5bfc \u8bfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7ae0\u4ecb\u7ecdT\u7ec6\u80de\u7684\u6297\u539f\u8bc6\u522b\u5206\u5b50\uff0c\u5373T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u3002\u4e0a\u56fe\u6982\u8ff0\u4e86TCR\u7ec4\u88c5\u7684\u4e3b\u8981\u6b65\u9aa4\u3002\u5982\u7b2c2\u7ae0<\/span>\u6240\u8ff0\uff0cTCRs\u8bc6\u522b\u80bd\u6297\u539f\u6709\u4e00\u4e2a\u5fc5\u8981\u6761\u4ef6\uff0c\u90a3\u5c31\u662f\u8be5\u6297\u539f\u9700\u8981\u7531\u81ea\u8eab\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff08MHC\uff09\u5206\u5b50\u8fdb\u884c\u5c55\u793a\uff0c\u6ca1\u6709\u4e0eMHC\u7ed3\u5408\u7684\u6297\u539f\u662f\u4e0d\u80fd\u88abTCR\u8bc6\u522b\u7684\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0c\u5b83\u4eec\u5177\u6709\u53cc\u91cd\u7279\u5f02\u6027\u3002\u8fd9\u4e0eB\u7ec6\u80de\u6297\u539f\u8bc6\u522b\u5206\u5b50\uff08\u6297\u4f53\uff09\u4e0d\u540c\uff0c\u6297\u4f53\u662f\u76f4\u63a5\u7ed3\u5408\u5404\u79cd\u80bd\u548c\u975e\u80bd\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7ae0\u6700\u540e\u8ba8\u8bba\u4e86TCR\u548cMHC\u6297\u539f\u4e4b\u95f4\u5982\u4f55\u901a\u8fc7\u76f8\u4e92\u4f5c\u7528\u5f62\u6210\u514d\u75ab\u7a81\u89e6\u7684\u4e00\u90e8\u5206\u3002\u5c3d\u7ba1\u6297\u539f\u8bc6\u522b\u673a\u5236\u4e0d\u540c\uff0c\u4f46TCR\u5728\u7ed3\u6784\u4e0a\u4e0e\u514d\u75ab\u7403\u86cb\u767d\u76f8\u4f3c\uff08Fig 7.1<\/span>\uff09\u3002\u50cfB\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u4e00\u6837\uff0cTCR\u4e5f\u662f\u5448\u514b\u9686\u5206\u5e03\u3002T\u7ec6\u80de\u7684\u6bcf\u4e2a\u514b\u9686\u90fd\u8868\u8fbe\u4e0d\u540c\u7684\u6297\u539f\u53d7\u4f53\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 7.1<\/span> T\u7ec6\u80de\u53d7\u4f53(TCR)\u7684\u7ed3\u6784\u4e0e\u514d\u75ab\u7403\u86cb\u767d\u7684\u6bd4\u8f83 <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T\u7ec6\u80de\u53d7\u4f53\u7684\u7ed3\u6784<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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TCR\u662f\u5f02\u4e8c\u805a\u4f53\u819c\u86cb\u767d\u3002TCR\u5305\u62ec\u4e24\u79cd\u7c7b\u578b\u7684\u53d7\u4f53\uff0c\u5206\u522b\u662f\u03b1\u03b2\u94fe\u53d7\u4f53\u548c\u03b3\u03b4\u94fe\u53d7\u4f53\uff0c\u643a\u5e26\u6709\u4e24\u79cd\u53d7\u4f53\u7684T\u6dcb\u5df4\u7ec6\u80de\u7684\u6bd4\u4f8b\u5206\u522b\u7ea6\u5360\u4eba\u7c7b\u603bT\u6dcb\u5df4\u7ec6\u80de\u768495%\u548c5%\u3002\u8fd9\u4e9b\u53d7\u4f53\u4e2d\u7684\u6bcf\u4e00\u4e2a\u94fe\u7684\u5206\u5b50\u91cf\u90fd\u572840,000\u81f360,000\u4e4b\u95f4\u3002\u6bcf\u6761\u94fe\u7684\u7ec6\u80de\u5916\u90e8\u5206\u7531\u4e24\u4e2a\u57df\u7ec4\u6210\uff08\u89c1Fig 7.1<\/span>\uff09\u3002\u6574\u4f53\u7ed3\u6784\u7c7b\u4f3c\u4e8e\u514d\u75ab\u7403\u86cb\u767d\uff08Ig\uff09\u7684\u6297\u539f\u7ed3\u5408\u7247\u6bb5\uff08Fab\uff09\u7684\u7ed3\u6784\u3002\u8ddd\u819c\u6700\u8fdc\u7684TCR\u57df\u4e0eIg\u53ef\u53d8\uff08V\uff09\u533a\u57df\u76f8\u4f3c\uff0c\u800c\u8ddd\u819c\u6700\u8fd1\u7684TCR\u57df\u4e0eIg\u6052\u5b9a\uff08C\uff09\u533a\u57df\u76f8\u4f3c\u3002\u6297\u539f\u7ed3\u5408\u7531\u03b1\u03b2\u6216\u03b3\u03b4\u94fe\u7684V\u7ed3\u6784\u57df\u4ea7\u751f\u7684\u4f4d\u70b9\u8fdb\u884c\u3002\u5df2\u7ecf\u786e\u5b9aTCR\u7ec6\u80de\u5916\u90e8\u5206\u7684\u4e09\u7ef4\uff083-D\uff09\u7ed3\u6784\uff08Fig 7.2<\/span>\uff09\uff0c\u4e0eIg\u5177\u6709\u5f88\u5927\u76f8\u4f3c\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig7.2 <\/span>T\u7ec6\u80de\u53d7\u4f53(TCR)\u7684\u4e09\u7ef4\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bb8\u591a\u5177\u6709\u4e0d\u540c\u7279\u5f02\u6027\u7684TCRs\u5df2\u83b7\u5f97\u86cb\u767d\u8d28\u548c\u6838\u9178\u5e8f\u5217\u6570\u636e\u3002\u8fd9\u4e9b\u5e8f\u5217\u7684\u5206\u6790\u7ed3\u679c\u8868\u660e\u5728\u53ef\u53d8\u533a\u4e2d\u5b58\u5728\u4e09\u4e2a\u9ad8\u53d8\uff08hv\uff09\u533a\u30023-D\u7ed3\u6784\u8868\u660e\uff0c\u8fd9\u4e9b\u9ad8\u53d8\u533a\u6392\u5217\u4e3a\u76f8\u5bf9\u5e73\u5766\u7684\u8868\u9762\uff08\u89c1Fig 7.2<\/span>\uff09\uff0c\u8be5\u8868\u9762\u540c\u65f6\u4e0eMHC\u5206\u5b50\u548c\u6297\u539f\u80bd\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u63a5\u89e6\u3002<\/p>\n<\/section>\n

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\u03b1\u03b2 T\u7ec6\u80de\u53d7\u4f53<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u03b1\u03b2 TCR\u662f\u5728\u5177\u6709MHC\u9650\u5236\u6027T\u7ec6\u80de\u4e0a\u53d1\u73b0\u7684\u4e3b\u8981TCR\uff0895\uff05\uff09\u3002\u901a\u5e38\u6211\u4eec\u63d0\u5230TCR\uff0c\u6307\u7684\u662f\u03b1\u03b2 TCR\u3002\u4e0d\u540c\u7c7b\u578b\u7684\u8f85\u52a9T\u7ec6\u80de\u4e5f\u662f\u03b1\u03b2 T\u7ec6\u80de\uff0c\u5927\u591a\u6570\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u4e5f\u662f\u5982\u6b64\u3002\u03b1\u03b2 TCR\u8bc6\u522b\u7531MHC\u5206\u5b50\u5448\u9012\u7684\u80bd\u6297\u539f\uff08\u7b2c2\u30013\u30019\u548c10\u7ae0<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u03b3\u03b4 T\u7ec6\u80de\u53d7\u4f53<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u03b3\u03b4 TCR\u5b58\u5728\u4e8e\u5c11\u6570\uff085\uff05\uff09\u4ebaT\u7ec6\u80de\u4e0a\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u80f8\u817a\u4e2d\u4f5c\u4e3a\u4e0e\u8868\u8fbe\u03b1\u03b2 TCR\u5206\u5b50\u7684\u7ec6\u80de\u4e0d\u540c\u7684\u7ec6\u80de\u8c31\u884d\u751f\uff08\u7b2c15\u7ae0<\/span>\uff09\u3002\u5728\u67d0\u4e9b\u4e0a\u76ae\u7ec4\u7ec7\u4e2d\uff0c\u03b3\u03b4 T\u7ec6\u80de\u6570\u91cf\u66f4\u591a\uff0c\u8fd9\u5bfc\u81f4\u4e86\u4ee5\u4e0b\u5047\u8bbe\uff1a\u5b83\u4eec\u662f\u7b2c\u4e00\u9053\u9632\u7ebf\uff0c\u5e76\u53ef\u80fd\u5f15\u53d1\u5bf9\u4e0a\u76ae\u8fb9\u754c\uff0c\u5982\u76ae\u80a4\uff0c\u7ecf\u5e38\u9047\u5230\u7684\u5fae\u751f\u7269\u7684\u53cd\u5e94\u3002\u540c\u6837\uff0c\u03b3\u03b4 T\u7ec6\u80de\u4e0e\u03b1\u03b2 T\u7ec6\u80de\u5728\u4e24\u4e2a\u91cd\u8981\u65b9\u9762\u6709\u6240\u4e0d\u540c\u3002\u9996\u5148\uff0c\u4ed6\u4eec\u65e2\u53ef\u4ee5\u8bc6\u522b\u8102\u8d28\u5206\u5b50\u4e5f\u53ef\u4ee5\u8bc6\u522b\u80bd\u3002\u7b2c\u4e8c\uff0c\u4ed6\u4eec\u4e0d\u80fd\u603b\u662f\u8bc6\u522bMHC\uff0c\u4e0d\u662fMHC\u9650\u5236\u6027\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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T\u7ec6\u80de\u53d7\u4f53\u57fa\u56e0\u591a\u6837\u6027\u7684\u4ea7\u751f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f16\u7801TCR\u94fe\u7684\u57fa\u56e0\u7247\u6bb5\u7684\u7ed3\u6784\u975e\u5e38\u7c7b\u4f3c\u4e8eIg\u91cd\u94fe\u548c\u8f7b\u94fe\u57fa\u56e0\u533a\u6bb5\u7684\u7ed3\u6784\u3002\u5982Fig 7.3<\/span>\u6240\u793a\uff0c\u03b1\u548c\u03b3\u94fe\u7684\u57fa\u56e0\u4e0eIg \u03ba\u548c\u03bb\u8f7b\u94fe\u7684\u57fa\u56e0\u7c7b\u4f3c\uff0c\u56e0\u4e3a\u5b83\u4eec\u4ec5\u4f7f\u7528V\u548cJ\u6bb5\u3002\u03b2\u548c\u03b4\u94fe\u7684\u57fa\u56e0\u7c7b\u4f3c\u4e8eIg\u91cd\u94fe\u57fa\u56e0\uff0c\u5b83\u4eec\u4f7f\u7528V\uff0cD\u548cJ\u57fa\u56e0\u6bb5\u3002\u4e0eIg\u57fa\u56e0\u7684\u4e0d\u540c\u4e4b\u5904\u5728\u4e8e\uff0cTCR C\u533a\u57df\u57fa\u56e0\u8f83\u5c11\u3002\u4f8b\u5982\uff0c\u53ea\u6709\u4e00\u4e2aC\u03b1\u57fa\u56e0\uff0c\u6709\u4e24\u4e2aC\u03b2\u57fa\u56e0\uff0c\u4f46\u5b83\u4eec\u5728\u529f\u80fd\u4e0a\u4f3c\u4e4e\u662f\u76f8\u540c\u7684\u3002\u8fd9\u4e0e\u5176\u4e2dC\u533a\u5305\u62ec\u00b5\uff0c\u03b4\uff0c\u03b3\uff0c\u03b5\u548c\u03b1\u7c7b\u4ee5\u53ca\u03bb\u4e9a\u578b\uff08\u03bb1\u81f3\u03bb4\uff09\u7b49\u7684Igs\u76f8\u53cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 7.3 <\/span>\u4eba\u7c7bT\u7ec6\u80de\u53d7\u4f53\u57fa\u56e0\u7684\u7ec4\u7ec7<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6297\u539f\u523a\u6fc0T\u7ec6\u80de\u4e4b\u524d\u4ea7\u751f\u591a\u6837\u6027\u7684\u673a\u5236\u4e0eB\u7ec6\u80de\u4e2d\u4ea7\u751f\u591a\u6837\u6027\u7684\u673a\u5236\u76f8\u540c\uff08\u7b2c6\u7ae0<\/span>\uff09\u3002\u4f46\u5728\u6297\u539f\u523a\u6fc0\u540e\uff0cT\u7ec6\u80de\u5185\u9014\u5f84\u4e0eB\u7ec6\u80de\u5b8c\u5168\u4e0d\u540c\u3002\u6297\u539f\u523a\u6fc0\u540e\uff0cIg\u57fa\u56e0\u7ee7\u7eed\u591a\u6837\u5316\uff08\u4f8b\u5982\u901a\u8fc7\u4f53\u7ec6\u80de\u8d85\u7a81\u53d8\u548c\u7c7b\u522b\u8f6c\u6362\uff0c\u5c06V\u533a\u8fde\u63a5\u5230\u53e6\u4e00\u4e2aC\u533a\uff09\uff0c\u800cTCR\u7684\u57fa\u56e0\u4fdd\u6301\u4e0d\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TCR\u57fa\u56e0\u5728\u80f8\u817a\u91cd\u6392\uff08\u7b2c15\u7ae0<\/span>\uff09\u3002\u5408\u6210TCR\u94fe\u7684\u57fa\u672c\u5206\u5b50\u6b65\u9aa4\u4e0e\u9488\u5bf9Ig\u8f7b\u94fe\u548c\u91cd\u94fe\u6240\u8ff0\u7684\u5206\u5b50\u6b65\u9aa4\u975e\u5e38\u76f8\u4f3c\uff08Fig 7.4<\/span>\uff09\u3002\u5bf9\u4e8eB\u6dcb\u5df4\u7ec6\u80de\u4e2d\u7684Ig\u57fa\u56e0\uff0c\u5305\u62ecRAG-1\u548cRAG-2\u9176\u5728\u5185\u7684V\uff08D\uff09J\u91cd\u7ec4\u9176\u4e0eTCR\u57fa\u56e0\u91cd\u6392\u6709\u5173\uff0c\u8fd9\u4e9b\u529f\u80fd\u7684\u7f3a\u9677\u4f1a\u5f71\u54cdB\u7ec6\u80de\u548cT\u7ec6\u80de\uff08BOX 7.1<\/span>\uff09\u3002\u5bf9\u4e8e\u03b1\u94fe\uff0cV\u57fa\u56e0\u533a\u6bb5\uff08\u5982V\u03b12\uff09\u548cJ\u57fa\u56e0\u533a\u6bb5\uff08\u5982J\u03b15\uff09\u91cd\u7ec4\u4ee5\u5f62\u6210V\u533a\u5916\u663e\u5b50\uff08\u5982V\u03b12 J\u03b15\uff09\u3002V\u533a\u7684\u8f6c\u5f55\u548cC\u03b1\u5916\u663e\u5b50\u4e00\u8d77\u4ea7\u751f\u521d\u7ea7RNA\u8f6c\u5f55\u672c\u3002\u8be5RNA\u7684\u526a\u63a5\u4ea7\u751f\u4e00\u4e2a\u4fe1\u4f7fRNA\uff08mRNA\uff09\uff0c\u8be5\u4fe1\u4f7fRNA\u5728\u7ffb\u8bd1\u65f6\u4f1a\u4ea7\u751fTCR \u03b1\u94fe\u86cb\u767d\uff08\u53c2\u89c1Fig 7.4<\/span>\uff09\uff0c\u5176\u65b9\u5f0f\u7c7b\u4f3c\u4e8eFig 6.3A<\/span>\u548cFig 6.4<\/span>\u4e2d\u9488\u5bf9Ig\u8f7b\u94fe\u6240\u8ff0\u65b9\u5f0f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 7.4 <\/span>\u4eba\u03b1\u03b2T\u7ec6\u80de\u53d7\u4f53\u7684\u5408\u6210\u4e0e\u8868\u8fbe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u03b2\u94fe\u7684\u7ec4\u88c5\u4e0eIg\u91cd\u94fe\u7684\u7ec4\u88c5\u76f8\u4f3c\uff0c\u9996\u5148\u5c06\u03b1D\u548c\u03b1J\u57fa\u56e0\u7247\u6bb5\u7ec4\u5408\u5728\u4e00\u8d77\uff0c\u7136\u540e\u5c06\u8be5DJ\u5355\u5143\u7ec4\u5408\u5230V\u57fa\u56e0\u7247\u6bb5\u4e0a\uff0c\u5982Fig 7.4<\/span>\u4e2dD\u03b21\uff0cJ\u03b21\u548cV\u03b23\u3002\u7136\u540e\uff0c\u5b8c\u6574\u7684V\u533a\u5916\u663e\u5b50\u4e0eC\u03b21\u4e00\u8d77\u8f6c\u5f55\uff0c\u5f62\u6210\u4e00\u7ea7RNA\u8f6c\u5f55\u7269\u3002RNA\u526a\u63a5\u4ea7\u751fmRNA\uff0c\u7ffb\u8bd1\u540e\u4ea7\u751fTCR\u7684\u03b2\u94fe\uff08\u53c2\u89c1Fig 7.4<\/span>\uff09\uff0c\u65b9\u5f0f\u7c7b\u4f3c\u4e8eFig 6.3B\u548cFig 6.5\u4e2d\u9488\u5bf9Ig\u91cd\u94fe\u3002\u03b1\u548c\u03b2\u94fe\u50cf\u5176\u4ed6\u4e0e\u819c\u7ed3\u5408\u86cb\u767d\u4e00\u6837\u5728\u7c97\u9762\u5185\u8d28\u7f51\u4e2d\u7ffb\u8bd1\uff0c\u7ecf\u8fc7\u5185\u8d28\u7f51\u548c\u9ad8\u5c14\u57fa\u4f53\u5904\u7406\u540e\u5728\u7ec6\u80de\u8868\u9762\u819c\u4e0a\u8868\u8fbe\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e\u514d\u75ab\u7403\u86cb\u767d\u4e00\u6837\uff0cTCR\u591a\u6837\u6027\u4ea7\u751f\u7684\u673a\u5236\u5305\u62ec\uff1a\uff081\uff09\u5b58\u5728\u591a\u4e2aV\u533a\u57fa\u56e0\uff0c\uff082\uff09\u672b\u7aef\u8131\u6c27\u6838\u82f7\u9178\u8f6c\u79fb\u9176\uff08TdT\uff09\u7684\u4e0d\u7cbe\u786e\u8fde\u63a5\u548c\u6838\u82f7\u9178\u6dfb\u52a0\u800c\u4ea7\u751f\u7684\u8fde\u63a5\u591a\u6837\u6027\uff0c\uff083\uff09\u968f\u673a\u4ea7\u751f\u94fe\u6761\u7ec4\u5408\u3002\u4e0eIg\u4e0d\u540c\uff0cTCR\u57fa\u56e0\u4e2d\u6ca1\u6709\u4f53\u7ec6\u80de\u8d85\u7a81\u53d8\u3002\u4f46\u662f\uff0c\u603b\u7684\u6f5c\u5728B\u7ec6\u80de\u548cT\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u79cd\u7c7b\u76f8\u4f3c\uff0c\u56e0\u4e3a\u7f3a\u4e4f\u4f53\u7ec6\u80de\u8d85\u7a81\u53d8\u88abTCR\u57fa\u56e0\u4e2d\u66f4\u5927\u7684\u8fde\u63a5\u591a\u6837\u6027\u7684\u62b5\u6d88\u4e86\uff08\u7b2c9\u7ae0<\/span>\uff09\u3002\u4ece\u7406\u8bba\u4e0a\u8bb2\uff0cTCR\u6570\u76ee\u53ef\u80fd\u9ad8\u8fbe1016<\/sup>\u81f31018<\/sup>\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u662f\u7531\u591a\u6837\u6027\u4ea7\u751f\u3002TCR\u8fde\u63a5\u591a\u6837\u6027\u7684\u4e00\u4e2a\u4f8b\u8bc1\u662fTCR \u03b1\u94fe\u53ef\u7528\u7684J\u7247\u6bb5\u6570\u91cf\u662fIg \u03ba\u548c\u03bb\u8f7b\u94fe\u768410\u500d\u4ee5\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6297\u539f\u7684\u8bc6\u522b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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TCR\u4ec5\u51fa\u73b0\u5728\u7ec6\u80de\u8868\u9762\u3002T\u7ec6\u80de\u6ca1\u6709\u50cfB\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u90a3\u6837\u8868\u8fbe\u53e6\u4e00\u79cd\u5206\u6ccc\u5f62\u5f0f\u7684\u6f5c\u529b\u3002Fig 7.5<\/span>\u663e\u793aTCR\u5982\u4f55\u4e0e\u81ea\u8eabMHC\u5206\u5b50\u5448\u9012\u6297\u539f\u80bd\u76f8\u4e92\u4f5c\u7528\u3002\u5904\u7406\u540e\uff08\u7b2c10\u7ae0<\/span>\uff09\u7684\u5927\u591a\u6570\u80bd\u6297\u539f\u90fd\u663e\u793a\u5728MHC\u51f9\u69fd\uff08\u7b2c2\u30013\u548c8\u7ae0<\/span>\uff09\u4e2d\u4e0eTCR\u7ed3\u5408\u3002\u5c11\u6570\u88ab\u79f0\u4e3a\u8d85\u6297\u539f\u7684\u7269\u8d28\u53ef\u72ec\u7acb\u4e8e\u6297\u539f\u52a0\u5de5\u548c\u5448\u9012\u800c\u6fc0\u6d3bT\u7ec6\u80de\u3002\u8fd9\u4e9b\u8d85\u6297\u539f\u540c\u65f6\u7ed3\u5408MHC II\u7c7b\u5206\u5b50\u548c\u5177\u6709\u67d0\u4e9b\u7279\u5b9a\u03b2\u94fe\u7684TCR\u3002\u901a\u8fc7\u8fd9\u6837\u505a\uff0c\u5b83\u4eec\u6fc0\u6d3b\u5e26\u6709\u8be5V\u03b2\u533a\u57df\u7684T\u7ec6\u80de\uff0c\u5e76\u5f15\u8d77\u5927\u89c4\u6a21\u7684\u514d\u75ab\u53cd\u5e94\uff08BOX 7.2<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 7.5 <\/span>T\u7ec6\u80de\u53d7\u4f53(TCR)\u4e0e\u80bd\u548c\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\u7684\u76f8\u4e92\u4f5c\u7528 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bf9TCR-\u80bd-MHC\u590d\u5408\u7269\u8fdb\u884c\u4e863-D\u7ed3\u6784\u5206\u6790\u3002Fig 7.6<\/span>\u663e\u793a\u4e86MHC I\u7c7b\u5206\u5b50\uff08HLA-A2\uff09\uff0c\u75c5\u6bd2\u80bd\u548c\u7279\u5f02\u6027TCR\uff0c\u8be5TCR V\u533a\u7684\u9ad8\u53d8\u5e8f\u5217\u4ea7\u751f\u4e00\u4e2a\u201c\u5e73\u5766\u201d\u7684\u8868\u9762\uff0c\u8be5\u8868\u9762\u4e0e\u6297\u539f\u80bd\u7684\u6b8b\u57fa\u4ee5\u53ca\u4f4d\u4e8eMHC\u5206\u5b50\u03b11\u548c\u03b12\u57df\u4e2d\u7684\u4e00\u4e9b\u591a\u6001\u6c28\u57fa\u9178\u6b8b\u57fa\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 7.6 <\/span>MHC-\u80bd-T\u7ec6\u80de\u53d7\u4f53(TCR)\u590d\u5408\u7269\u7684\u4e09\u7ef4\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6d89\u53caT\u7ec6\u80de\u529f\u80fd\u7684\u8f85\u52a9\u5206<\/strong>\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982Fig 7.7<\/span>\u6240\u793a\uff0c\u51e0\u79cd\u5206\u5b50\u53c2\u4e0eT\u7ec6\u80de\u529f\u80fd\u3002\u8fd9\u4e9b\u5206\u5b50\u5f62\u6210\u514d\u75ab\u7a81\u89e6\u7684\u4e00\u4fa7\uff0cT\u7ec6\u80de\u5229\u7528\u514d\u75ab\u7a81\u89e6\u4e0e\u5176\u4ed6\u7ec6\u80de\u901a\u8baf\u3002\u672c\u7ae0\u4e3b\u8981\u5173\u6ce8\u7ed3\u5408\u6297\u539f\u7684TCR \u03b1\u03b2\u548c\u03b3\u03b4\u94fe\u3002TCR\u6ca1\u6709CD3\u590d\u5408\u7269\uff08\u7531\u56db\u4e2a\u4e0d\u540c\u7684\u8de8\u819c\u86cb\u767d\u94fe\uff1a\u03b3\uff0c\u03b4\uff0c\u03b5\u548c\u03b6\uff09\u5219\u65e0\u6cd5\u6b63\u5e38\u53d1\u6325\u53d7\u4f53\u529f\u80fd\u3002\u5728TCR\u7ed3\u5408\u6297\u539f\u540e\uff0cCD3\u5206\u5b50\u901a\u8fc7\u4fe1\u53f7\u8f6c\u5bfc\u81f3\u7ec6\u80de\u8d28\uff08\u7b2c11\u7ae0<\/span>\uff09\u4ece\u800c\u4f7fT\u7ec6\u80de\u6d3b\u5316\u3002\u5176\u4ed6\u5206\u5b50\uff0c\u5982CD11a\u7b49\u6574\u5408\u7d20\uff0c\u53c8\u79f0\u767d\u7ec6\u80de\u529f\u80fd\u76f8\u5173\u6297\u539f1\uff08LFA-1\uff09\uff0c\u5728T\u7ec6\u80de\u4e0e\u5176\u9776\u7ec6\u80de\u8d77\u9ecf\u9644\u4f5c\u7528\uff08\u89c1Fig 7.7<\/span>\uff09\uff0c\u800c\u53e6\u4e00\u4e9b\u5728\u9ecf\u9644\u53ca\u4fe1\u53f7\u8f6c\u5bfc\u4e2d\u8d77\u4f5c\u7528\u3002\u5176\u4e2d\u6700\u91cd\u8981\u7684\u662fCD4\u548cCD8\uff0c\u5b83\u4eec\u901a\u8fc7\u5206\u522b\u4e0eII\u7c7b\u6216I\u7c7bMHC\u5206\u5b50\u7ed3\u5408\u6765\u7a33\u5b9aTCR-\u80bd-MHC\u590d\u5408\u7269\uff0c\u4ee5\u53ca\u901a\u8fc7\u5c06\u916a\u6c28\u9178\u6fc0\u9176(Src\u5bb6\u65cf\u7684\u6210\u5458Lck)\u5e26\u5230CD3\u548c\u03b6\u86cb\u767d\u7684\u7ec6\u80de\u8d28\u5c3e\u90e8\u9644\u8fd1\u4ece\u800c\u4fc3\u8fdb\u4fe1\u53f7\u8f6c\u5bfc\u548c\u7ec6\u80de\u6fc0\u6d3b\uff0c\u589e\u5f3a\u7279\u5b9aT\u7ec6\u80de\u5e94\u7b54\u3002\u643a\u5e26CD4\u7684T\u7ec6\u80de\u88ab\u79f0\u4e3aT\u8f85\u52a9\u7ec6\u80de\uff0c\u56e0\u4e3a\u5b83\u4eec\u901a\u5e38\u4fc3\u8fdb\u5176\u4ed6\u7ec6\u80de\u5e94\u7b54\u3002\u7136\u800c\uff0cT\u8f85\u52a9\u7ec6\u80de\u7684\u4e00\u4e2a\u5b50\u96c6\uff0c\u79f0\u4e3a\u8c03\u8282\u6027T\u7ec6\u80de(Tregs)\uff0c\u80fd\u591f\u6291\u5236\u5176\u4ed6T\u7ec6\u80de\u3002\u643a\u5e26CD8\u7684T\u7ec6\u80de\u5177\u6709\u6740\u4f24\u529f\u80fd\uff0c\u5982\u8bf1\u5bfc\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u51cb\u4ea1\uff0c\u4e5f\u88ab\u79f0\u4e3a\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de(CTL)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 7.7 <\/span>\u53c2\u4e0eT\u7ec6\u80de\u529f\u80fd\u7684\u8f85\u52a9\u5206\u5b50 <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7a81\u89e6\u4e0e\u795e\u7ecf\u7a81\u89e6\u7684\u4e0d\u540c\u4e4b\u5904\u5728\u4e8e\u5b83\u662f\u4e00\u4e2a\u77ac\u65f6\u7ed3\u6784\u3002\u4f8b\u5982\uff0c\u5f53T\u7ec6\u80de\u8bc6\u522b\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u4e0a\u7684\u80bd\u6297\u539f\u65f6\uff0c\u7a81\u89e6\u4f1a\u5f62\u6210\u51e0\u4e2a\u5c0f\u65f6\u3002\u5728\u6b64\u671f\u95f4\uff0c\u4e24\u4e2a\u7ec6\u80de\u4e4b\u95f4\u53cc\u5411\u901a\u4fe1\u3002\u4e00\u65e6T\u7ec6\u80de\u5bf9\u6297\u539f\u4ea7\u751f\u53cd\u5e94\uff0c\u7a81\u89e6\u5c31\u4f1a\u5206\u89e3\u5e76\u91ca\u653eT\u7ec6\u80de\u4e0e\u5176\u4ed6\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u5bf9\u6297\u539f\u4ea7\u751f\u53cd\u5e94\uff08Fig 7.8<\/span>\uff09\u3002\u8fd9\u4e9b\u8fc7\u7a0b\u5c06\u5728\u7b2c16\u7ae0<\/span>\u4e2d\u8fdb\u4e00\u6b65\u63cf\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 7.8 <\/span>\u8be5\u56fe\u663e\u793a\u4e86CD4+T\u7ec6\u80de\u548c\u6297\u539f\u63d0\u5448\u7ec6\u80de\u4e4b\u95f4\u7684\u514d\u75ab\u7a81\u89e6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 7.1 <\/span>\u91cd\u7ec4\u6fc0\u6d3b\u57fa\u56e0\uff08RAG-1\uff0cRAG-2\uff09\u4ea7\u7269\u7f3a\u9677\uff0c\u5bfc\u81f4\u5e38\u67d3\u8272\u4f53\u9690\u6027\u91cd\u75c7\u8054\u5408\u514d\u75ab\u7f3a\u9677<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

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\u4e00\u4e2a\u4e09\u5468\u5927\u7684\u5973\u5b69\u88ab\u5979\u7684\u7236\u6bcd\u5e26\u5230\u533b\u9662\u3002\u81ea\u51fa\u751f\u540e\u5a74\u513f\u4f53\u91cd\u51cf\u8f7b\u4e8610\uff05\uff0c\u547c\u5438\u56f0\u96be\u3002\u7236\u6bcd\u88ab\u8ba4\u4e3a\u662f\u8fd1\u4eb2\uff0c\u6ca1\u6709\u5176\u4ed6\u503c\u5f97\u6ce8\u610f\u7684\u4e1c\u897f\u3002\u7ecf\u68c0\u67e5\uff0c\u5a74\u513f\u5b58\u5728\u5e7f\u6cdb\u7684\u5ff5\u73e0\u83cc\u76ae\u80a4\u611f\u67d3\u3001\u547c\u5438\u8870\u7aed\u3002\u80f8\u7247\u663e\u793a\u8036\u6c0f\u80ba\u5b62\u5b50\u866b\u80ba\u708e\u7684\u7279\u5f81\u6027\u8868\u73b0\uff0c\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u8f83\u4f4e\u3002\u5f53\u4f7f\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\uff08\u7b2c5\u7ae0<\/span>\uff09\u8ba1\u6570\u5404\u79cd\u7c7b\u578b\u7684\u6dcb\u5df4\u7ec6\u80de\u65f6\u53d1\u73b0T\u7ec6\u80de\u548cB\u7ec6\u80de\u5b8c\u5168\u7f3a\u5931\u3002\u6709\u4e00\u4e9b\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u3002\u57fa\u56e0\u6d4b\u8bd5\u786e\u8ba4\u7531RAG1\u548cRAG2\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u5e38\u67d3\u8272\u4f53\u9690\u6027\u91cd\u75c7\u8054\u5408\u514d\u75ab\u7f3a\u9677\uff08ARSCID\uff09\u3002\u5a74\u513f\u88ab\u8f6c\u8bca\u5e72\u7ec6\u80de\u79fb\u690d\u3002<\/p>\n

\u91cd\u7ec4\u6fc0\u6d3b\u57fa\u56e0\uff08RAG\uff09\u9176\u542f\u52a8B\u7ec6\u80de\u4e2d\u7684\u514d\u75ab\u7403\u86cb\u767d\u57fa\u56e0\u91cd\u6392\uff08\u7b2c6\u7ae0\u548c<\/span>\u7b2c14\u7ae0<\/span>\uff09\u3002\u5982\u672c\u7ae0\u6240\u8ff0\uff0c\u5b83\u4eec\u5728T\u7ec6\u80de\u4e2d\u5bf9\u4e8eT\u7ec6\u80de\u53d7\u4f53\u57fa\u56e0\u91cd\u6392\u4e5f\u5f88\u91cd\u8981\uff08\u7b2c15\u7ae0<\/span>\uff09\u3002RAG-1\u6216RAG-2\u7684\u7f3a\u9677\u5bfc\u81f4AR-SCID\uff0c\u8fd9\u4e00\u4e8b\u5b9e\u8bc1\u660e\u5176\u91cd\u8981\u6027\u3002\u7531RAG1\u548cRAG2\u7a81\u53d8\u5f15\u8d77\u7684AR-SCID\u5f62\u5f0f\u4e0e\u8be5\u75be\u75c5\u7684\u5176\u4ed6\u5f62\u5f0f\u4e0d\u540c\uff0c\u56e0\u4e3aT\u548cB\u7ec6\u80de\u5b8c\u5168\u7f3a\u4e4f\u3002\u4f46\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u53d1\u73b0\u4e86NK\u7ec6\u80de\u3002\u56e0\u6b64\u8fd9\u79cd\u75be\u75c5\u79f0\u4e3aTB-SCID\u3002<\/p>\n

TB-SCID\u662f\u4e00\u79cd\u7f55\u89c1\u7efc\u5408\u5f81\uff0c\u5982\u679c\u6ca1\u6709\u6765\u81ea\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\uff08HLA\uff09\u517c\u5bb9\u4f9b\u4f53\u7684\u9aa8\u9ad3\u79fb\u690d\uff08BMT\uff09\uff0c2\u5c81\u65f6\u4f1a\u81f4\u547d\u3002\u8be5\u75c5\u5728\u6700\u521d\u51e0\u5468\u5185\u4ee5\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u548c\u53cd\u590d\u611f\u67d3\u7684\u5f62\u5f0f\u51fa\u73b0\u5728\u5a74\u513f\u4e2d\uff0c\u53ea\u80fd\u68c0\u6d4b\u5230\u5f88\u5c0f\u7684\u80f8\u817a\u3002\u8fd9\u4e9b\u5a74\u513f\u53cd\u590d\u53d1\u4f5c\u80ba\u708e\uff0c\u4e2d\u8033\u708e\u548c\u76ae\u80a4\u611f\u67d3\uff0c\u5e76\u6301\u7eed\u611f\u67d3\u673a\u4f53\u5982\u767d\u8272\u5ff5\u73e0\u83cc\u548c\u8036\u6c0f\u5047\u4e1d\u9175\u6bcd\u83cc\u3002\u5bf9\u4e8e\u7236\u6bcd\u548c\u513f\u79d1\u533b\u751f\u6765\u8bf4\u5b69\u5b50\u5904\u4e8e\u6781\u5927\u7684\u5371\u9669\u4e4b\u4e2d\u3002\u4f46\u662f\uff0c\u5982\u679c\u8db3\u591f\u65e9\u5730\u8fdb\u884cBMT\uff0c\u8d85\u8fc780\uff05\u7684\u513f\u7ae5\u53ef\u4ee5\u5b58\u6d3b\u3002SCID\u4f5c\u4e3a\u4e00\u79cd\u7efc\u5408\u75c7\u5f88\u5c11\u89c1\uff0cTB-SCID\u66f4\u4e3a\u7f55\u89c1\u3002\u76ee\u524dBMT\u4e4b\u540e\u6709\u6570\u767e\u4e2a\u4eba\u8fd8\u6d3b\u7740\uff0c\u53ef\u4ee5\u7ea0\u6b63\u5404\u79cd\u5f62\u5f0f\u7684SCID\u3002BMT\u5c06\u5728\u7b2c34\u7ae0<\/span>\u4e2d\u8fdb\u4e00\u6b65\u8ba8\u8bba\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 7.2<\/strong><\/span> \u8d85\u6297\u539f\u548c\u4e2d\u6bd2\u6027\u4f11\u514b\u7efc\u5408\u75c7<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
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<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u4e00\u540d23\u5c81\u7684\u5973\u6027\u5728\u5de5\u4f5c\u4e2d\u6655\u5012\u540e\u88ab\u9001\u5f80\u6025\u8bca\u3002\u60a3\u8005\u51fa\u73b0\u5927\u9762\u79ef\u7ea2\u75b9\uff0c\u9ad8\u6e29\uff0838.9\u00b0C\uff09\u548c\u4f4e\u8840\u538b\uff08\u6536\u7f29\u538b\u4e3a86\u6beb\u7c73\u6c5e\u67f1\uff09\u3002\u636e\u6089\uff0c\u5979\u5728\u6708\u7ecf\u671f\u95f4\u4f7f\u7528\u4e86\u536b\u751f\u68c9\u6761\u3002\u6025\u67e5\u8840\u5e38\u89c4\u663e\u793a\u5979\u6709\u6025\u6027\u80be\u529f\u80fd\u8870\u7aed\u548c\u809d\u708e\uff0c\u5bf9\u4e2d\u6bd2\u6027\u4f11\u514b\u7efc\u5408\u75c7\u8fdb\u884c\u4e86\u521d\u6b65\u8bca\u65ad\u3002\u62ff\u53bb\u68c9\u6761\uff0c\u8865\u6db2\u4f7f\u60a3\u8005\u82cf\u9192\u5e76\u6062\u590d\u5065\u5eb7\u3002\u5728\u63a5\u4e0b\u6765\u7684\u51e0\u5929\u4e2d\uff0c\u8840\u57f9\u517b\u4e3a\u9634\u6027\u30022\u5468\u540e\u5979\u7684\u624b\u638c\u76ae\u80a4\u8131\u76ae\u3002\u8fd9\u4e9b\u7279\u5f81\u53ef\u4ee5\u786e\u8ba4\u4e2d\u6bd2\u6027\u4f11\u514b\u7efc\u5408\u5f81\u7684\u56de\u987e\u6027\u8bca\u65ad\u3002<\/p>\n

\u67d0\u4e9b\u7ec6\u83cc\u548c\u75c5\u6bd2\u4ea7\u751f\u7684\u67d0\u4e9b\u86cb\u767d\u8d28\u65e0\u9700\u52a0\u5de5\u5373\u53ef\u88ab\u8868\u8fbe\u03b1\u03b2 T\u7ec6\u80de\u53d7\u4f53\uff08TCRs\uff09\u7684T\u7ec6\u80de\u8bc6\u522b\u3002\u5b83\u4eec\u76f4\u63a5\uff08\u4f46\u5728\u6297\u539f\u8bc6\u522b\u4f4d\u70b9\u4e4b\u5916\uff09\u4e0e\u8bb8\u591aTCR V\u03b2\u5e8f\u5217\u7ed3\u5408\u6fc0\u6d3bT\u7ec6\u80de\u3002\u5b83\u4eec\u8fd8\u4e0eMHC II\u7c7b\u5206\u5b50\u7684\u5916\u8868\u9762\u7ed3\u5408\uff08Fig 7.9<\/span>\uff09\u3002\u7531\u4e8e\u5b83\u4eec\u4e0e\u8bb8\u591aT\u7ec6\u80de\u7684TCR V\u03b2\u533a\u7684\u7ed3\u5408\uff0c\u8d85\u6297\u539f\u80fd\u591f\u6fc0\u6d3b1\uff05-20\uff05\u7684T\u7ec6\u80de\uff0c\u5e76\u5bfc\u81f4\u8840\u6db2\u4e2d\u5b58\u5728\u9ad8\u6c34\u5e73\u7684\u7ec6\u80de\u56e0\u5b50\u3002\u9ad8\u6c34\u5e73\u7684\u7ec6\u80de\u56e0\u5b50\u88ab\u79f0\u4e3a\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\uff0c\u4f1a\u5bfc\u81f4\u4ee5\u4e2d\u6bd2\u6027\u4f11\u514b\u7efc\u5408\u75c7\u4e3a\u7279\u5f81\u7684\u4f4e\u8840\u538b\u548c\u591a\u5668\u5b98\u8870\u7aed\u3002\u8bf7\u6ce8\u610f\u5c40\u90e8\u611f\u67d3\uff08\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\u4e3a\u53d7\u611f\u67d3\u7684\u68c9\u6761\uff09\u5f15\u8d77\u5a01\u80c1\u751f\u547d\u7684\u75c7\u72b6\u3002\u611f\u67d3\u6027\u4f11\u514b\u662f\u5f15\u8d77\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u548c\u8840\u538b\u964d\u4f4e\u7684\u53e6\u4e00\u4e2a\u539f\u56e0\uff08\u7b2c21\u7ae0<\/span>\uff09\u3002\u5728\u611f\u67d3\u6027\u4f11\u514b\u7684\u60c5\u51b5\u4e0b\uff0c\u611f\u67d3\u901a\u5e38\u5f88\u666e\u904d\uff0c\u8840\u57f9\u517b\u901a\u5e38\u662f\u9633\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 7.9  <\/span>MHC II\u7c7b\u5206\u5b50\u548cT\u7ec6\u80de\u53d7\u4f53TCR<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 7.3 <\/span>\u5206\u5316\u5206\u5b50\u7c07<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

\n
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<\/svg><\/section>\n<\/section>\n
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\u5728\u514d\u75ab\u5b66\u4e2d\uff0c\u7ec6\u80de\u8868\u9762\u5206\u5b50\u79f0\u4e3aCD\uff0c\u5982CD3\u3002\u8be5\u7f29\u5199\u4ee3\u8868\u5206\u5316\u7c07\uff0c\u662f\u53d1\u73b0\u8fd9\u4e9b\u5206\u5b50\u65f6\u9996\u5148\u4f7f\u7528\u7684\u672f\u8bed\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5df2\u7ecf\u63cf\u8ff0\u4e86\u6570\u767e\u79cdCD\u5206\u5b50\u3002\u6700\u8457\u540d\u7684\u662fCD4\uff0c\u5b83\u662fHIV\u9644\u7740\u4e8eT\u7ec6\u80de\u7684\u7ec6\u80de\u53d7\u4f53\u3002\u68c0\u6d4bCD4+<\/sup>T\u7ec6\u80de\u7684\u6570\u91cf\u53ef\u4ee5\u4ee5\u8bc4\u4f30HIV\u4ecb\u5bfc\u7684\u514d\u75ab\u7f3a\u9677\u75be\u75c5\u7684\u75c5\u60c5\u8fdb\u5c55\uff08\u7b2c33\u7ae0<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/section>\n<\/section>\n

<\/section>\n

\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |  \u9648\u4f73\u8587 \u5f20\u6587\u9759 \u848b\u4fca\u535a<\/span><\/span> <\/span> <\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u7f57\u4f73\u4f73<\/span><\/span><\/section>\n
\u5ba1\u6838 |  \u738b\u5764 \u5b8b\u4e50<\/span><\/section>\n

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<\/p>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/span><\/a><\/a><\/a>
<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

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BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/section>\n
\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a><\/span><\/section>\n
\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/span><\/a>
<\/section>\n
PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/span><\/a>
<\/section>\n
\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/span><\/a>
<\/section>\n
\u5982\u4f55\u6d4b\u91cfWestern Blot\u6761\u5e26\u7070\u5ea6\u503c\uff1f(GelPro\u8f6f\u4ef6\u4f7f\u7528\u65b9\u6cd5)<\/span><\/a>
<\/section>\n

\u5b9e\u9a8c\u4e2d\u5982\u4f55\u6311\u9009\u5230\u4e00\u652f\u597d\u7528\u7684\u6297\u4f53\uff1f<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/mpprofile><\/section>\n
\u70b9\u51fb\u4e0a\u65b9\u540d\u7247\u5173\u6ce8\u672c\u53f7\u5373\u53ef\u83b7\u53d6\u540e\u7eed\u66f4\u591a\u7cbe\u5f69\u5185\u5bb9~<\/span><\/section>\n
\u7531\u4e8e\u5fae\u4fe1\u8ba2\u9605\u53f7\u63a8\u9001\u89c4\u5219\u66f4\u65b0\uff0c\u5efa\u8bae\u60a8\u5c06\u201cOncoLab\u5b9e\u9a8c\u5ba4\u201d\u8bbe\u4e3a\u661f\u6807\uff0c\u4fbf\u53ef\u5728\u6d88\u606f\u680f\u4e2d\u4fbf\u6377\u5730\u627e\u5230\u6211\u4eec\uff0c\u53ca\u65f6\u83b7\u53d6\u6700\u65b0\u6587\u7ae0\u5185\u5bb9\uff01<\/span><\/section>\n


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<\/p>\n

\u987a\u624b\u70b9\u4e2a\u201c\u8d5e\u201d\u548c\u201c\u5728\u770b\u201d\u5427\uff0c\u611f\u8c22\uff01<\/span><\/section>\n<\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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