{"id":3471,"date":"2021-04-04T17:10:28","date_gmt":"2021-04-04T09:10:28","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2021\/04\/04\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac10%e7%ab%a0%ef%bc%9a%e6%8a%97%e5%8e%9f%e7%9a%84%e5%a4%84%e7%90%86%e5%92%8c%e5%91%88%e9%80%92\/"},"modified":"2021-04-04T17:10:28","modified_gmt":"2021-04-04T09:10:28","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac10%e7%ab%a0%ef%bc%9a%e6%8a%97%e5%8e%9f%e7%9a%84%e5%a4%84%e7%90%86%e5%92%8c%e5%91%88%e9%80%92","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2021\/04\/04\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac10%e7%ab%a0%ef%bc%9a%e6%8a%97%e5%8e%9f%e7%9a%84%e5%a4%84%e7%90%86%e5%92%8c%e5%91%88%e9%80%92\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012"},"content":{"rendered":"
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\u672c\u7ae0\u8ba8\u8bba\u6297\u539f\u7ecf\u8fc7\u5904\u7406\uff0c\u8fdb\u800c\u5f62\u6210\u6297\u539f\u80bd\u2013MHC\u5206\u5b50\u590d\u5408\u7269\uff0c\u5e76\u5c06\u6297\u539f\u5448\u9012\u7ed9\u03b1\u03b2 T\u7ec6\u80de\u53d7\u4f53\u7684\u8fc7\u7a0b\u3002\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u5916\u6e90\u6027\u6297\u539f\u4e0e\u5185\u6e90\u6027\u6297\u539f\u7684\u5728\u7ec6\u80de\u5185\u7684\u8fd0\u8f93\u9014\u5f84\u662f\u4e0d\u540c\u7684\uff0c\u672c\u7ae0\u4e2d\u5c06\u91cd\u70b9\u63cf\u8ff0MHC I\u7c7b\u5206\u5b50\u6216II\u7c7b\u5206\u5b50\u4ecb\u5bfc\u7684\u8fd9\u4e9b\u9014\u5f84\u5177\u6709\u4ec0\u4e48\u6837\u7684\u4e0d\u540c\u7279\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b63\u5982\u524d\u9762\u8ba8\u8bba\u7684\u90a3\u6837\uff0c\u4eba\u4f53\u5df2\u7ecf\u5f62\u6210\u4e86\u975e\u5e38\u6709\u6548\u7684\u5c4f\u969c\u963b\u6b62\u5916\u6765\u6297\u539f(\u5982\u7ec6\u83cc\u6216\u75c5\u6bd2)\u8fdb\u5165\u800c\u5f15\u53d1\u75be\u75c5\u3002\u5982\u679c\u5916\u6765\u5f02\u7269\u6216\u6297\u539f(\u5982\u6bd2\u7d20)\u8fdb\u5165\u4f53\u5185\uff0c\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7684\u9632\u5fa1\u5c4f\u969c(\u5982\u541e\u566c\u7ec6\u80de)\u53ef\u80fd\u4f1a\u5728B\u6216T\u7ec6\u80de\u9047\u5230\u6297\u539f\u4e4b\u524d\u5c06\u5176\u6467\u6bc1\uff0c\u5e76\u5f15\u53d1\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u3002\u5f88\u5c11\u6709\u5916\u6765\u6297\u539f\u80fd\u5728\u56fa\u6709\u514d\u75ab\u7684\u5bbf\u4e3b\u9632\u5fa1\u7cfb\u7edf\u4e2d\u5b8c\u597d\u65e0\u635f\u5730\u5b58\u6d3b\u3002\u5982\u679c\u6709\uff0c\u4ec5\u9700\u8981\u6781\u5c11\u6570\u7684B\u6216T\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u53c2\u4e0e\u5c31\u80fd\u542f\u52a8\u4fdd\u62a4\u6027\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

B\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u53ef\u4e0e\u5165\u4fb5\u7684\u5fae\u751f\u7269\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528\uff0c\u4f46\u03b1\u03b2 TCRs\u53ea\u80fd\u8bc6\u522b\u201c\u5904\u7406\u8fc7\u7684\u201d\u6297\u539f\u80bd\u3002\u6b64\u5916\uff0c\u03b1\u03b2 TCR\u5bf9\u5916\u6765\u6297\u539f\u7684\u8bc6\u522b\u53ea\u6709\u5728\u5916\u6765\u6297\u539f\u9644\u7740\u5728\u5176\u4ed6\u7ec6\u80de\u7684\u8868\u9762\u65f6\u624d\u80fd\u5b8c\u6210\u3002(\u6297\u539f\u63d0\u5448\u7ec6\u80deAPCs\u6216\u9776\u7ec6\u80de\uff1bFig 10.1<\/span>)<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 10.1<\/span> \u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u5411T\u7ec6\u80de\u63d0\u5448\u6297\u539f<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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APC\u5305\u62ec\u5de8\u566c\u7ec6\u80de\u3001B\u7ec6\u80de\u548c\u5404\u79cd\u6811\u7a81\u72b6\u7ec6\u80de(\u7b2c2\u300112\u548c20\u7ae0<\/span>)\u3002\u6811\u7a81\u72b6\u7ec6\u80de\u662fAPCs\u4e2d\u7684\u4f5c\u7528\u5353\u8d8a\u7684\u4e13\u804c\u6297\u539f\u63d0\u5448\u7ec6\u80de (BOX 10.1\uff1b\u89c1\u7b2c12\u7ae0\u548c\u7b2c20\u7ae0<\/span>)\u3002\u8fd9\u4e9bAPCs\u5728\u541e\u566c\u3001\u5904\u7406\u548c\u5448\u9012\u7ec6\u80de\u5916\u6297\u539f\u65b9\u9762\u975e\u5e38\u6709\u6548\uff0c\u901a\u5e38\u4e0e\u5171\u523a\u6fc0\u5206\u5b50\u4e00\u8d77\u5b8c\u6210\u514d\u75ab\u6fc0\u6d3b\u8fc7\u7a0b\u3002\u6297\u539f\u80bd\u5728APCs\u4e2d\u4e0eMHC II\u7c7b\u5206\u5b50\u7ed3\u5408\u540e\u5448\u9012\u7ed9T\u7ec6\u80de(\u7b2c8\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9776\u7ec6\u80de\u662f\u7ec6\u80de\u5185\u611f\u67d3\u4e86\u75c5\u539f\u4f53\u7684\u4efb\u610f\u6709\u6838\u7ec6\u80de\uff0c\u6076\u6027\u7ec6\u80de\u4e5f\u53ef\u80fd\u6210\u4e3a\u9776\u7ec6\u80de\u3002\u6765\u81ea\u7ec6\u80de\u5185\u75c5\u539f\u4f53\u6216\u80bf\u7624\u7684\u6297\u539f\uff08\u5185\u6e90\u6027\u6297\u539f\uff09\u88ab\u52a0\u5de5\u6210\u591a\u80bd\uff0c\u7136\u540e\u4e0eMHC I\u7c7b\u5206\u5b50\u7ed3\u5408\u540e\u5448\u9012\u7ed9T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T\u6dcb\u5df4\u7ec6\u80de\u5bf9\u6297\u539f\u7684\u8bc6\u522b\u662fMHC\u9650\u5236\u6027\u7684\u3002T\u6dcb\u5df4\u7ec6\u80de\u7684\u4e3b\u8981\u4e9a\u7fa4\uff0c\u8f85\u52a9\u6027T\u7ec6\u80de(CD4+)\u548c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de(CD8+)\u5177\u6709\u4e0d\u540c\u7684MHC\u9650\u5236\u6027\u3002CD4+T\u7ec6\u80de\u4e0eAPC\u7684\u76f8\u4e92\u4f5c\u7528\u662fMHC II\u7c7b\u5206\u5b50\u9650\u5236\u6027\u7684\uff0cCD8+T\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\u662fMHC I\u7c7b\u5206\u5b50\u9650\u5236\u6027\u7684(\u7b2c7\u30018\u548c15\u7ae0<\/span>)\u3002\u6297\u539f\u8f6c\u53d8\u6210\u5408\u9002\u957f\u5ea6\u7684\u591a\u80bd\u5e76\u4e0e\u81ea\u8eabMHC\u5206\u5b50\u7ed3\u5408\u7684\u8fc7\u7a0b\u5c31\u79f0\u4e3a\u6297\u539f\u5904\u7406\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u80de\u8d28\u4e2d\u4ea7\u751f\u7684\u6297\u539f\u80bd\uff0c\u4f8b\u5982\u5728\u80de\u8d28\u4e2d\u590d\u5236\u7684\u75c5\u6bd2\u548c\u7ec6\u83cc\uff0c\u4e0eI\u7c7bMHC\u5206\u5b50\u7ed3\u5408\uff0c\u5448\u9012\u7ed9CD8+T\u7ec6\u80de(\u7b2c7\u7ae0<\/span>)\u3002\u5185\u4f53\u4e2d\u4ea7\u751f\u7684\u6297\u539f\u80bd\u662f\u7531\u7ec6\u80de\u5916\u6297\u539f\uff08\u5982\u6bd2\u7d20\uff09\u7684\u5185\u541e\u6444\u53d6\u4ea7\u751f\u7684\uff0c\u6216\u7531\u5185\u4f53\u6355\u83b7\u7684\u5fae\u751f\u7269\uff08\u5982\u5de8\u566c\u7ec6\u80de\u541e\u566c\u67d0\u4e9b\u7ec6\u83cc\uff09\u540e\u4ea7\u751f\u7684\uff0c\u53ef\u4e0eII\u7c7bMHC\u5206\u5b50\u7ed3\u5408\uff0c\u8fdb\u800c\u5448\u9012\u7ed9CD4+T\u7ec6\u80de\u3002\u8fd9\u610f\u5473\u7740CD8+T\u7ec6\u80de\u53ef\u4ee5\u76d1\u6d4b\u7ec6\u80de\u5185\u73af\u5883\uff0c\u800cCD4+T\u7ec6\u80de\u53ef\u4ee5\u76d1\u6d4b\u7ec6\u80de\u5916\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6297\u539f\u6240\u7ecf\u8fc7\u7684\u7ec6\u80de\u5185\u5904\u7406\u9014\u5f84\u662f\u51b3\u5b9a\u6297\u539f\u901a\u8fc7I\u7c7b\u8fd8\u662fII\u7c7bMHC\u5206\u5b50\u5448\u9012\u7684\u4e3b\u8981\u56e0\u7d20\uff0c\u800c\u4e0d\u662f\u7531\u6297\u539f\u672c\u8eab\u7684\u4efb\u4f55\u7279\u6b8a\u6027\u8d28\u51b3\u5b9a\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80de\u5916\u6216\u5916\u6e90\u6027\u6297\u539f\u53ef\u80fd\u662f\u80de\u5916\u86cb\u767d\uff0c\u5982\u86cb\u767d\u8d28\u75ab\u82d7\uff0c\u4e5f\u53ef\u80fd\u662f\u75c5\u539f\u4f53\u88ab\u6444\u53d6\u5230\u5185\u541e\u4f53\u540e\u6d88\u5316\u4ea7\u751f\u7684\u86cb\u767d\u3002\u8fd9\u4e9b\u6297\u539f\u88ab\u52a0\u5de5\u540e\u6700\u7ec8\u4e0eMHC II\u7c7b\u5206\u5b50\u7ed3\u5408\u5448\u9012\u7ed9CD4+T\u6dcb\u5df4\u7ec6\u80de(Fig 10.2A<\/span>)\u3002\u9996\u5148\uff0c\u5b83\u4eec\u5fc5\u987b\u7531APC\u5185\u5316\u3002\u53ef\u6eb6\u6027\u6297\u539f\u88ab\u5b8c\u6574\u5730\u5185\u541e\u3002\u75c5\u539f\u4f53\u901a\u8fc7\u7279\u6b8a\u7684\u541e\u566c\u8fc7\u7a0b\u5185\u5316(\u7b2c21\u7ae0<\/span>)\uff0c\u901a\u8fc7\u8fd9\u4e00\u8fc7\u7a0b\u5b83\u4eec\u8fdb\u5165\u5185\u4f53\u9014\u5f84\u3002\u6709\u4e9b\u751f\u7269\u5df2\u7ecf\u8fdb\u5316\u5230\u53ef\u4ee5\u5728\u5185\u4f53\u4e2d\u751f\u5b58\uff0c\u5982\u7ed3\u6838\u5206\u679d\u6746\u83cc\u3002\u8fd9\u4e9b\u751f\u7269\u4f4d\u4e8e\u7ec6\u80de\u5185\uff0c\u4f46\u5728\u67d0\u79cd\u610f\u4e49\u4e0a\u4ecd\u7136\u662f\u7ec6\u80de\u5916\u7684\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0d\u5b58\u5728\u4e8e\u80de\u6d46\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u968f\u540e\uff0c\u542b\u6709\u6297\u539f\u7684\u5185\u4f53\u4f1a\u9178\u5316\u5e76\u4e0e\u6eb6\u9176\u4f53\u878d\u5408(\u89c1Fig 10.2<\/span>)\uff0c\u7136\u540e\u88ab\u7ec6\u80de\u86cb\u767d\u9176\u964d\u89e3\u4e3a\u4e0d\u540c\u5927\u5c0f\u7684\u591a\u80bd\uff0c\u6700\u7ec8\u964d\u89e3\u4e3a\u6c28\u57fa\u9178\u3002\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u4ea7\u751f\u7684\u80bd\u6bb5(9\u523030+\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa)\u53ef\u4ee5\u4e0eMHC II\u7c7b\u5206\u5b50\u7ed3\u5408\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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APC\u8fd8\u5728\u5185\u8d28\u7f51\u4e2d\u5408\u6210\u65b0MHC II\u7c7b\u5206\u5b50\u3002\u8fd9\u4e9b\u5206\u5b50\u901a\u8fc7\u9ad8\u5c14\u57fa\u4f53\uff0c\u6700\u7ec8\u6210\u4e3a\u56ca\u6ce1\u7684\u4e00\u90e8\u5206\uff0c\u56ca\u6ce1\u4ece\u9ad8\u5c14\u57fa\u4f53\u8131\u79bb\uff0c\u5e76\u53ef\u4e0e\u542b\u6709\u81ea\u80de\u5916\u6216\u56ca\u6ce1\u6765\u6e90\u7684\u6297\u539f\u80bd\u7684\u5185\u4f53\u6ce1\u878d\u5408\u3002\u4ece\u5185\u8d28\u7f51\u5230\u9ad8\u5c14\u57fa\u4f53\u7684\u9014\u5f84\u4e2d\uff0cMHC II\u7c7b\u5206\u5b50\u7684\u7a7a\u7ed3\u5408\u4f4d\u70b9\u53d7\u5230\u6052\u5b9a\u94fe\u5206\u5b50\u7684\u201c\u4fdd\u62a4\u201d\uff0c\u4f7f\u5176\u4e0d\u80fd\u4e0e\u5176\u4ed6\u591a\u80bd(\u5982\u81ea\u8eab\u591a\u80bd)\u7ed3\u5408\u3002\u5728\u5185\u4f53\u7684\u9178\u6027\u73af\u5883\u4e2d\uff0c\u8fd9\u79cd\u4fdd\u62a4\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u4f5c\u7528\u88ab\u6d88\u9664\uff0c\u800c\u5185\u4f53\u4e2d\u4efb\u4f55\u5408\u9002\u7684\u80bd\u90fd\u53ef\u4e0eII\u7c7b\u5206\u5b50\u7ed3\u5408\u4f4d\u70b9\u7ed3\u5408\u3002\u542b\u6709\u88ab\u201c\u5360\u636e\u201d\uff08\u7ed3\u5408\u4e86\u6297\u539f\uff09\u7684MHC II\u7c7b\u5206\u5b50\u7684\u5185\u4f53\u968f\u540e\u88ab\u9001\u5165\u5916\u6ccc\u4f53\u9014\u5f84\uff0c\u5e76\u4e0e\u7ec6\u80de\u819c\u878d\u5408\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u5916\u6765\u6297\u539f\u53ef\u4ee5\u88ab\u5448\u9012\u7ed9\u5bf9\u5e94\u7684TCR\uff0c\u5e76\u8bf1\u5bfc\u76f8\u5e94\u7684T\u7ec6\u80de\u8fdb\u884c\u589e\u6b96(\u89c1Fig 10.2A<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 10.2<\/span> \u7ec6\u80de\u5916\u6297\u539f(A)\u548c\u7ec6\u80de\u5185\u6297\u539f(B)\u7684\u52a0\u5de5\u9014\u5f84<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u5185(\u5185\u6e90\u6027)\u6297\u539f<\/strong><\/p>\n<\/section>\n

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\u7ec6\u80de\u5185\u6216\u5185\u6e90\u6027\u6297\u539f\uff0c\u5982\u75c5\u6bd2\u86cb\u767d\uff0c\u7531\u201c\u9776\u7ec6\u80de\u201d\u5904\u7406\uff0c\u6700\u7ec8\u5728MHC I\u7c7b\u5206\u5b50\u4e0a\u5448\u9012\u7ed9CD8+T\u7ec6\u80de(\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff0c\u89c1Fig 10.2B<\/span>)\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5916\u6e90\u6027\u6297\u539f\u591a\u80bd\u662f\u5728\u7ec6\u80de\u8d28\u4e2d\u4ea7\u751f\u7684\u3002\u5982\u5728\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u7684\u7ec6\u80de\u8d28\u4e2d\u5408\u6210\u548c\u7ec4\u88c5\u7684\u75c5\u6bd2\u86cb\u767d\uff0c\u53ef\u80fd\u901a\u8fc7\u7ec6\u80de\u4e2d\u7684\u86cb\u767d\u964d\u89e3\u901a\u8def\u8fdb\u884c\u5206\u89e3\u3002\u5728Fig 10.2B<\/span>\u4e2d\uff0c\u75c5\u6bd2\u86cb\u767d\u6b63\u5728\u80de\u6d46\u4e2d\u5408\u6210\u3002\u7ec6\u80de\u964d\u89e3\u673a\u5236\u5982\u86cb\u767d\u9176\u4f53\u9014\u5f84\uff0c\u53ef\u80fd\u5bf9\u75c5\u6bd2\u86cb\u767d\u5206\u5b50\u8fdb\u884c\u5207\u5272\uff0c\u76f4\u5230\u5f62\u62108\u523011\u4e2a\u6b8b\u57fa\u7684\u591a\u80bd\uff1b\u8fd9\u79cd\u957f\u5ea6\u7684\u591a\u80bd\u80fd\u591f\u4e0eMHC I\u7c7b\u5206\u5b50\u7ed3\u5408\u3002\u8bb8\u591a\u80bd\u6bb5\u8fdb\u4e00\u6b65\u964d\u89e3\uff0c\u4f7f\u5b83\u4eec\u53d8\u5f97\u6ca1\u6709\u514d\u75ab\u539f\u6027\u3002\u7136\u800c\uff0c\u4e00\u4e9b\u8fdb\u5165\u4e86\u5185\u8d28\u7f51\u7684\u5408\u9002\u957f\u5ea6\u7684\u591a\u80bd\u5c31\u53ef\u4ee5\u4e0eMHC I\u7c7b\u5206\u5b50\u7ed3\u5408\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u4e2d\u542b\u6709\u5404\u79cd\u5404\u6837\u7684\u86cb\u767d\u9176\u4f53\uff0c\u8fd9\u4e9b\u86cb\u767d\u9176\u4f53\u4e0d\u65ad\u5730\u5faa\u73af\u964d\u89e3\u5229\u7528\u7ec6\u80de\u86cb\u767d\u3002\u8d1f\u8d23\u964d\u89e3\u75c5\u539f\u4f53\u86cb\u767d\u7684\u86cb\u767d\u9176\u4f53\u6210\u5206\u7684\u7f16\u7801\u57fa\u56e0\u4f4d\u4e8eMHC\u5927\u578b\u591a\u529f\u80fd\u86cb\u767d\u9176(LMP)\u57fa\u56e0\u4e2d(\u89c1Fig 8.1<\/span>)\u3002\u5728\u611f\u67d3\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u80de\u56e0\u5b50\u5e72\u6270\u7d20\u03b3\u88ab\u91ca\u653e\uff0c\u53ef\u589e\u52a0LMP\u7684\u8f6c\u5f55\uff0c\u56e0\u6b64\uff0c\u5728\u611f\u67d3\u671f\u95f4\uff0c\u75c5\u539f\u4f53\u7684\u86cb\u767d\u8d28\u5206\u89e3\u662f\u589e\u52a0\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u591a\u80bd\u7531\u6297\u539f\u9012\u5448\u76f8\u5173\u8f6c\u8fd0\u86cb\u767d(TAP)\u7684\u53cc\u94fe\u5206\u5b50\u643a\u5e26\u8fdb\u5165\u5185\u8d28\u7f51\uff0c\u5b83\u5141\u8bb8\u591a\u80bd\u7a7f\u8fc7\u5185\u8d28\u7f51\u7684\u53cc\u5c42\u819c\u7ed3\u6784\uff0c\u5e76\u7ed3\u5408\u5728\u5185\u8d28\u7f51\u5408\u6210\u7684\u65b0\u751fMHC I\u7c7b\u5206\u5b50\u7684\u591a\u80bd\u7ed3\u5408\u69fd\u4e2d\u3002\u8fd9\u4e9b\u5c0f\u6297\u539f\u80bd\u7684\u7ed3\u5408\u5bf9\u4e8eMHC I\u7c7b\u5206\u5b50\u6700\u540e\u9636\u6bb5\u7684\u7ec4\u88c5\u81f3\u5173\u91cd\u8981\u3002\u5728\u6ca1\u6709\u80bd\u7684\u60c5\u51b5\u4e0b\uff0cI\u7c7b\u5206\u5b50\u4e0d\u80fd\u6b63\u786e\u6298\u53e0\uff0c\u65e0\u6cd5\u8f6c\u8fd0\u5230\u7ec6\u80de\u8868\u9762\u3002MHC I\u7c7b\u5206\u5b50\u5728\u9ad8\u5c14\u57fa\u4f53\u4e2d\u5b8c\u6210\u751f\u7269\u5408\u6210\uff0c\u5e76\u901a\u8fc7\u80de\u5916\u9014\u5f84\u79fb\u52a8\u5230\u80de\u819c\u3002\u5728\u9ad8\u5c14\u57fa\u4f53\u4e0e\u80de\u819c\u878d\u5408\u540e\uff0c\u6297\u539f\u80bd-MHC I\u7c7b\u5206\u5b50\u590d\u5408\u7269\u53ef\u4e0e\u5e26\u6709\u80fd\u7ed3\u5408\u8fd9\u79cdMHC-\u6297\u539f\u590d\u5408\u4f53\u7684\u53d7\u4f53\u7684T\u6dcb\u5df4\u7ec6\u80de(CD8+\u6216\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de)\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0eMHC I\u8fd8\u662fMHC II\u7ed3\u5408\uff1f<\/strong><\/p>\n<\/section>\n

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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5982Fig 10.2<\/span>\u6240\u793a\uff0c\u6297\u539f\u4e0eMHC I\u7c7b\u6216II\u7c7b\u5206\u5b50\u7ed3\u5408\u7684\u53ef\u80fd\u6027\u5b8c\u5168\u7531\u5176\u901a\u8fc7\u7ec6\u80de\u8f6c\u8fd0\u7684\u9014\u5f84\u51b3\u5b9a\uff0c\u5e76\u975e\u7531\u6297\u539f\u7684\u67d0\u4e9b\u7279\u6b8a\u6027\u8d28\u51b3\u5b9a\u3002\u8fd9\u79cd\u6297\u539f\u5904\u7406\u65b9\u5f0f\u4e5f\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u591a\u7cd6\u3001\u8102\u7c7b\u548c\u6838\u9178\u4e0d\u80fd\u88ab\u03b1\u03b2 T\u7ec6\u80de\u8bc6\u522b\uff1b\u56e0\u4e3a\u5b83\u4eec\u6ca1\u6709\u7ecf\u8fc7\u52a0\u5de5\u5904\u7406\u4f7f\u5176\u53ef\u4ee5\u7ed3\u5408\u5230MHC\u5206\u5b50\u7684\u7ed3\u5408\u69fd\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u80de\u6d46\u6765\u6e90\u548c\u5185\u4f53\u6765\u6e90\u7684\u6297\u539f\uff0c\u5206\u522b\u4e0eMHC I\u7c7b\u6216II\u7c7b\u5206\u5b50\u76f8\u7ed3\u5408\uff0c\u5bfc\u81f4\u4e0d\u540cT\u7ec6\u80de\u4e9a\u7fa4\u7684\u6fc0\u6d3b(Fig 10.3\u548cTABLE 10.1<\/span>)\u3002\u901a\u8fc7MHC II\u7c7b\u5206\u5b50\u63d0\u5448\u7684\u7ec6\u80de\u5916\u6297\u539f\u53ef\u6fc0\u6d3bCD4+T\u7ec6\u80de\u3002CD4+T\u7ec6\u80de\u662f\u8f85\u52a9\u6027\u7684\uff0c\u4f8b\u5982\uff0cCD4+T\u7ec6\u80de\u53ef\u901a\u8fc7\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\u6216\u523a\u6fc0B\u7ec6\u80de\u4ea7\u751f\u6297\u4f53\u6765\u63d0\u4f9b\u5e2e\u52a9(\u89c1Fig  10.3A<\/span>)\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0cCD4+T\u7ec6\u80de\u4e3a\u643a\u5e26\u6297\u539f\u7684\u7ec6\u80de\u63d0\u4f9b\u5e2e\u52a9\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0cMHC I\u7c7b\u5206\u5b50\/\u80de\u5185\u6297\u539f\u590d\u5408\u7269\u53ef\u6fc0\u6d3bCD8+T\u7ec6\u80de\uff0c\u5f62\u6210\u53ef\u6291\u5236\u611f\u67d3\u7684\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u3002\u5982\u679c\u4e0d\u6210\u529f\uff0cCD8+T\u7ec6\u80de\u5c06\u901a\u8fc7\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u6216\u7ec6\u80de\u88c2\u89e3\u6765\u6740\u6b7b\u9776\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 10.3<\/span> \u5c06\u6297\u539f\u5448\u9012\u7ed9T\u7ec6\u80de\u7684\u4e0d\u540c\u4e9a\u7fa4<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u75c5\u539f\u4f53\u5bf9\u52a0\u5de5\u9014\u5f84\u7684\u9003\u907f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u679c\u75c5\u539f\u4f53\u53ef\u4ee5\u907f\u514d\u6297\u539f\u80bd\u88abMHC\u5206\u5b50\u8bc6\u522b\uff0c\u4ed6\u4eec\u5c31\u80fd\u591f\u907f\u514d\u88ab\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u68c0\u6d4b\u5230\u3002\u56e0\u6b64\uff0c\u8bb8\u591a\u75c5\u539f\u4f53\u80fd\u591f\u5e72\u6270\u6297\u539f\u5904\u7406\u7684\u8fc7\u7a0b\u3002\u4f8b\u5982\uff0c\u7ed3\u6838\u5206\u679d\u6746\u83cc\u5df2\u7ecf\u83b7\u5f97\u4e86\u6291\u5236\u541e\u566c\u5c0f\u4f53-\u6eb6\u9176\u4f53\u878d\u5408\u7684\u80fd\u529b\u3002\u8fd9\u6291\u5236\u4e86\u5b83\u4eec\u63a5\u89e6\u6eb6\u9176\u4f53\u86cb\u767d\u9176\uff0c\u51cf\u5c11\u4e86\u5206\u679d\u6746\u83cc\u591a\u80bd\u4e0eMHC\u5206\u5b50\u7ed3\u5408\u5448\u9012\u5230\u7ec6\u80de\u8868\u9762\u7684\u53ef\u80fd\u6027\u3002\u5728\u75c5\u6bd2\u4e2d\uff0c\u5df2\u53d1\u73b0\u6709\u51e0\u79cd\u75c5\u6bd2\u53ef\u901a\u8fc7\u5e72\u6270\u4e0eMHC I\u7c7b\u5206\u5b50\u7684\u7ed3\u5408\u6765\u5e72\u6270\u6297\u539f\u5904\u7406\u8fc7\u7a0b\u3002\u4f8b\u5982\uff0c\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2(HSV)\u53ef\u4e0eTAP\u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236\u591a\u80bd\u8fdb\u5165\u5185\u8d28\u7f51\uff0c\u5bfc\u81f4\u53ef\u4e0eMHC I\u7c7b\u5206\u5b50\u7ed3\u5408\u7684HSV\u591a\u80bd\u53d8\u5c11\u3002\u67d0\u4e9b\u817a\u75c5\u6bd2\u682a\u8868\u8fbe\u4e00\u79cd\u6291\u5236I\u7c7bMHC\u5206\u5b50\u8f6c\u5f55\u7684\u86cb\u767d\uff0c\u4ece\u800c\u51cf\u5c11\u4e86\u5411CD8+\u6dcb\u5df4\u7ec6\u80de\u5448\u9012\u817a\u75c5\u6bd2\u591a\u80bd\u7684MHC I\u7c7b\u5206\u5b50\u6570\u91cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5df2\u7ecf\u53d1\u73b0\u7684\u4e00\u4e9b\u75c5\u539f\u4f53\u9003\u907f\u5bbf\u4e3b\u9632\u5fa1\u7cfb\u7edf\u68c0\u6d4b\u7684\u65b9\u5f0f\u53cd\u6620\u4e86\u5bbf\u4e3b\u548c\u5fae\u751f\u7269\u4e4b\u95f4\u7684\u52a8\u6001\u4ea4\u4e92\uff0c\u56e0\u4e3a\u4e24\u8005\u90fd\u8bd5\u56fe\u751f\u5b58\u6216\u7e41\u884d\u3002\u540c\u6837\uff0c\u533b\u5b66\u7814\u7a76\u4e5f\u6b63\u5229\u7528\u5bf9\u6297\u539f\u5448\u9012\u8fc7\u7a0b\u7684\u4e86\u89e3\uff0c\u4e3a\u75c5\u539f\u4f53\u4ecb\u5bfc\u7684\u75be\u75c5\u5f00\u53d1\u66f4\u597d\u7684\u7597\u6cd5(BOX 10.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 10.1<\/span><\/strong> \u6811\u7a81\u72b6\u7ec6\u80de\uff1a\u5353\u8d8a\u7684\u6297\u539f\u63d0\u5448\u7ec6\u80de<\/span><\/p>\n<\/section>\n<\/section>\n

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\u6811\u7a81\u72b6\u7ec6\u80de(DC)\u6784\u6210\u4e86\u4e00\u4e2a\u5bf9\u514d\u75ab\u5e94\u7b54\uff0c\u7279\u522b\u662fT\u7ec6\u80de\u4ecb\u5bfc\u514d\u75ab\u81f3\u5173\u91cd\u8981\u7684\u7ec6\u80de\u7cfb\u7edf\u3002DC\u53ef\u6bd4\u5176\u4ed6\u7c7b\u578b\u7ec6\u80de\u66f4\u6709\u6548\u5730\u5448\u9012\u6297\u539f\u7ed9T\u7ec6\u80de\u3002\u7ecf\u5178DC(cDCs)\u548c\u6d46\u7ec6\u80de\u6837DC(pDCs)\u662fDC\u7684\u4e24\u79cd\u4e9a\u578b\u3002\u4e3a\u4e86\u6210\u4e3a\u597d\u7684\u6297\u539f\u63d0\u5448\u8005\uff0cDC\u7ecf\u5386\u4e86\u4ee5\u4e0b\u9002\u5e94\u6027\u7684\u8c03\u6574\uff1a<\/span><\/p>\n

1.DC\u5177\u6709\u5e7f\u6cdb\u7684\u4e0d\u65ad\u5f62\u6210\u548c\u6536\u7f29\u7684\u201c\u6811\u7a81\u201d(\u89c1Fig2.5<\/span>)\u3002\u8fd9\u589e\u52a0\u4e86\u5bf9\u7ec6\u80de\u5916\u6297\u539f\u8fdb\u884c\u6444\u53d6\u4ee5\u53ca\u4e0eT\u7ec6\u80de\u63a5\u89e6\u7684\u8868\u9762\u79ef\u3002<\/span><\/p>\n

2.DC\u5177\u6709\u8fd0\u52a8\u6027\uff0c\u5b83\u4eec\u4ece\u9aa8\u9ad3\u8fc1\u79fb\u5230\u5468\u56f4\u7ec4\u7ec7\uff0c\u5728\u90a3\u91cc\u83b7\u53d6\u7ec6\u80de\u5916\u6297\u539f\u3002DC\u5229\u7528Toll\u6837\u53d7\u4f53\u68c0\u6d4b\u611f\u67d3\u3002\u53d1\u73b0\u611f\u67d3\u65f6\uff0cDC\u4f1a\u4ece\u5916\u5468\u5668\u5b98\u8fc1\u79fb\u5230\u6dcb\u5df4\u5668\u5b98\uff0c\u7279\u522b\u662f\u5668\u5b98\u7684T\u7ec6\u80de\u533a\u57df\uff0c\u6bd4\u5982\u6dcb\u5df4\u7ed3\u3002<\/span><\/p>\n

3.DC\u8868\u8fbe\u975e\u5e38\u9ad8\u6c34\u5e73\u7684\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)II\u7c7b\uff0c\u8fd9\u6709\u52a9\u4e8e\u5b83\u4eec\u5411CD4+T\u7ec6\u80de\u5448\u9012\u6297\u539f\u3002<\/span><\/p>\n

4.DC\u53ef\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\uff0c\u5982cDCs\u5206\u6ccc\u767d\u4ecb\u7d2012(IL-12)\u6fc0\u6d3bT\u7ec6\u80de\u7684T-helper 1\u4e9a\u7fa4(TH1)\u3002pDC\u5206\u6ccc\u5e72\u6270\u7d20-\u03b1\uff0c\u5177\u6709\u6297\u75c5\u6bd2\u4f5c\u7528\u3002<\/span><\/p>\n

DC\u4f5c\u4e3a\u6297\u539f\u63d0\u5448\u7ec6\u80de\u7684\u91cd\u8981\u6027\u4fc3\u4f7f\u4e86\u76f8\u5173\u4e34\u5e8a\u7814\u7a76\u7684\u53d1\u5c55\uff0c\u4ee5\u63a2\u7d22\u5b83\u4eec\u5728\u80bf\u7624\u6297\u539f\u75ab\u82d7\u4e2d\u7684\u5e94\u7528\u3002\u4f8b\u5982\uff0c\u8377\u8f7d\u4e86\u80bf\u7624\u6297\u539f\u7684DC\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 10.2<\/span><\/strong> \u6297\u539f\u63d0\u5448\u76f8\u5173\u8f6c\u8fd0\u86cb\u767dTAP\u7f3a\u4e4f<\/p>\n<\/section>\n<\/section>\n

\n
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<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u5185\u8d28\u7f51\u819c\u4e0a\u53d1\u73b0\u7684\u80bd\u8f6c\u8fd0\u86cb\u767dTAP\u7531\u4e24\u4e2a\u57fa\u56e0TAP-1\u548cTAP-2\u8fdb\u884c\u7f16\u7801\uff0c\u5b83\u4eec\u4f4d\u4e8eMHC II\u7c7b\u533a\u57df\u3002\u8f6c\u8fd0\u86cb\u767d\u662f\u4e24\u79cd\u86cb\u767d\u8d28TAP-1\u548cTAP-2\u7684\u5f02\u6e90\u4e8c\u805a\u4f53\u3002\u4e00\u4e9b\u7f55\u89c1\u7684\u7a81\u53d8\u53ef\u6539\u53d8TAP\u7684\u529f\u80fd\uff0c\u963b\u6b62\u591a\u80bd\u6709\u6548\u5730\u8fdb\u5165\u5185\u8d28\u7f51\u8154\u3002\u5728\u6ca1\u6709\u591a\u80bd\u6297\u539f\u7684\u60c5\u51b5\u4e0b\uff0cMHC I\u7c7b\u5206\u5b50\u662f\u4e0d\u7a33\u5b9a\u7684\uff0c\u53ea\u6709\u4e00\u5c0f\u90e8\u5206\u53ef\u901a\u8fc7\u80de\u5916\u9014\u5f84\u8fd0\u8f93\u5230\u7ec6\u80de\u8868\u9762\uff0c\u4ece\u800c\u5bfc\u81f4MHC I\u7c7b\u5206\u5b50\u7684\u8868\u8fbe\u51cf\u5c11\uff0c\u4e5f\u5e72\u6270\u4e86\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u7684\u5f62\u6210\u3002<\/span><\/p>\n

\u5728\u643a\u5e26TAP-1\u6216TAP-2\u7a81\u53d8\u7684\u4eba\u7c7b\u4e2d\uff0c\u53ef\u4ee5\u89c2\u5bdf\u5230\u6162\u6027\u4e0a\u547c\u5438\u9053\u611f\u67d3\u3002\u8fd9\u4e9b\u60a3\u8005\u7684\u4f53\u6db2\u514d\u75ab\u662f\u5b8c\u6574\u7684\uff0c\u7ec6\u80de\u514d\u75ab\u7684\u67d0\u4e9b\u65b9\u9762\u4e5f\u662f\u6b63\u5e38\u7684\uff0c\u5982\u60a3\u8005\u7684CD4+T\u7ec6\u80de\u53ef\u4ee5\u5bf9\u6297\u539f\u505a\u51fa\u53cd\u5e94\u3002\u7136\u800c\uff0c\u7f3a\u4e4fI\u7c7bMHC\u5206\u5b50\u7684\u8868\u8fbe\u5bfc\u81f4\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6570\u91cf\u7684\u51cf\u5c11,\u96be\u4ee5\u5bf9\u67d0\u4e9b\u547c\u5438\u9053\u75c5\u6bd2\u4ea7\u751f\u9002\u5f53\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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BOX 10.3<\/span><\/strong> DNA\u75ab\u82d7<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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\u5927\u591a\u6570\u75ab\u82d7\u5b58\u5728\u8fd9\u6837\u7684\u5c40\u9650\u6027\uff0c\u9664\u975e\u75ab\u82d7\u4e2d\u5305\u542b\u6d3b\u7684\u6709\u673a\u4f53\uff0c\u5426\u5219\u6297\u539f\u88ab\u6ce8\u5c04\u5230\u7ec6\u80de\u5916\u7a7a\u95f4\uff0c\u8fd9\u610f\u5473\u7740\u4e0d\u4f1a\u51fa\u73b0MHC I\u7c7b\u5206\u5b50\u7684\u6297\u539f\u63d0\u5448\uff0cCD8+T\u7ec6\u80de\u4e5f\u4e0d\u4f1a\u6fc0\u6d3b\u3002DNA\u75ab\u82d7\u662f\u6807\u51c6\u75ab\u82d7\u6280\u672f\u7684\u66ff\u4ee3\u54c1\uff0c\u7531\u4e92\u8865DNA (cDNA)\u5e8f\u5217\u7ec4\u6210\uff0c\u7f16\u7801\u53ef\u4ee5\u6fc0\u6d3b\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u7684\u86cb\u767d\u6297\u539f(\u5982\u75c5\u6bd2\u86cb\u767d\u6216\u80bf\u7624\u6297\u539f)\u3002\u201c\u57fa\u56e0\u67aa\u201d\u88ab\u7528\u6765\u5c06DNA\u6ce8\u5c04\u5230\u76ae\u4e0b\u7ec4\u7ec7\u7684\u7ec6\u80de\u4e2d\uff0ccDNA\u88ab\u8f6c\u5f55\u548c\u7ffb\u8bd1\uff0c\u86cb\u767d\u8d28\u5206\u5b50\u6700\u7ec8\u88ab\u5206\u89e3\u6210\u6297\u539f\u80bd\u3002\u4e00\u4e9b\u80bd\u8fdb\u5165\u5185\u8d28\u7f51\uff0c\u5e76\u4e0eMHC I\u7c7b\u5206\u5b50\u7ed3\u5408\u3002\u5728\u8f6c\u8fd0\u5230\u7ec6\u80de\u8868\u9762\u540e\uff0cT\u7ec6\u80de\u53ef\u5728APC\u8868\u9762\u68c0\u6d4b\u5230\u5b83\u4eec\u3002\u76ee\u524dDNA\u75ab\u82d7\u7597\u6cd5\u6b63\u5728\u8fdb\u884c\u8bc4\u4f30\uff0c\u4ee5\u5bfb\u627e\u9488\u5bf9HIV\u7684\u65b0\u7597\u6cd5\u3002\u65e9\u671f\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u5bf9\u67d0\u4e9b\u6297\u539f\u4ea7\u751f\u5f3a\u70c8\u800c\u6301\u4e45\u7684\u514d\u75ab\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u7f16\u7801cDNA\u7684\u86cb\u767d\u8d28\u5728\u80de\u6d46\u4e2d\u5408\u6210\uff0c\u8fd9\u53ef\u63d0\u4f9b\u4e00\u79cd\u5c06\u6297\u539f\u5f15\u5165\u7ec6\u80de\u5185\u8fdb\u884c\u5904\u7406\u7684\u9014\u5f84\uff0c\u4ece\u800c\u5f15\u53d1I\u7c7bMHC\u5206\u5b50\u7684\u5448\u9012\uff0c\u6fc0\u53d1CTL\u53cd\u5e94\u3002\u6807\u51c6\u7684\u75ab\u82d7\u65b9\u6cd5\uff0c\u5982\u808c\u8089\u6ce8\u5c04\u86cb\u767d\u8d28\u75ab\u82d7\uff0c\u5c06\u5bfc\u81f4\u86cb\u767d\u8d28\u88ab\u5f15\u5165\u5185\u541e\/II\u7c7b\u9014\u5f84\uff0c\u6700\u7ec8\u5448\u9012\u7ed9CD4+T\u7ec6\u80de\uff0c\u5e76\u6709\u53ef\u80fd\u523a\u6fc0\u4ea7\u751f\u6297\u4f53\u53cd\u5e94\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u53ef\u4ee5\u4ea7\u751f\u5176\u4ed6\u514d\u75ab\u7cfb\u7edf\u589e\u5f3a\u5242\u5982\u7ec6\u80de\u56e0\u5b50\u7684cDNAs\u6784\u5efa\u8d77\u6765\u4e5f\u76f8\u5bf9\u5bb9\u6613\uff0c\u5c06\u4ea7\u751f\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u7684cDNAs\u4e0e\u53ef\u4ea7\u751f\u6297\u539f\u86cb\u767d\u7684cDNAs\u7684\u8054\u5408\u8d77\u6765\u4f7f\u7528\u53ef\u80fd\u662f\u4e00\u79cd\u4e0d\u9519\u7684\u7597\u6cd5\uff0c\u5728\u672a\u6765\u6709\u53ef\u80fd\u5e7f\u6cdb\u63a8\u5e7f\u5e94\u7528\u3002DNA\u75ab\u82d7\u6b63\u5728\u8fdb\u5165\u4e73\u817a\u764c\u3001\u7ed3\u80a0\u764c\u548c\u524d\u5217\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4ed6\u80bf\u7624\u76f8\u5173\u7684DNA\u75ab\u82d7\u65e0\u7591\u4e5f\u5c06\u7d27\u968f\u5176\u540e\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/p>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |  \u848b\u4fca\u535a \u949f\u96ea\u83b9 \u5f90\u66fc\u65af<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u7f57\u4f73\u4f73<\/span><\/span><\/section>\n
\u5ba1\u6838 |  \u738b\u5764 \u5b8b\u4e50<\/span><\/section>\n


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\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n


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\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u672c\u7ae0\u8ba8\u8bba\u6297\u539f\u7ecf\u8fc7\u5904\u7406\uff0c\u8fdb\u800c\u5f62\u6210\u6297\u539f\u80bd\u2013MHC\u5206\u5b50\u590d\u5408\u7269\uff0c\u5e76\u5c06\u6297\u539f\u5448\u9012\u7ed9\u03b1\u03b2 T\u7ec6\u80de\u53d7\u4f53\u7684\u8fc7\u7a0b\u3002\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u5916\u6e90\u6027\u6297\u539f\u4e0e\u5185\u6e90\u6027\u6297\u539f\u7684\u5728\u7ec6\u80de\u5185\u7684\u8fd0\u8f93\u9014\u5f84\u662f\u4e0d\u540c\u7684\uff0c\u672c\u7ae0\u4e2d\u5c06\u91cd\u70b9\u63cf…<\/p>\n","protected":false},"author":1,"featured_media":3464,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[58],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3471"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3471"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3471\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3464"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3471"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3471"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}