{"id":3482,"date":"2020-12-22T10:17:01","date_gmt":"2020-12-22T02:17:01","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2020\/12\/22\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac2%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e5%9f%ba%e6%9c%ac%e6%a6%82%e5%bf%b5%e5%92%8c%e7%bb%84%e6%88%90\/"},"modified":"2020-12-22T10:17:01","modified_gmt":"2020-12-22T02:17:01","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac2%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e5%9f%ba%e6%9c%ac%e6%a6%82%e5%bf%b5%e5%92%8c%e7%bb%84%e6%88%90","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2020\/12\/22\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac2%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e5%9f%ba%e6%9c%ac%e6%a6%82%e5%bf%b5%e5%92%8c%e7%bb%84%e6%88%90\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210"},"content":{"rendered":"
\n

<\/span><\/p>\n

\n
\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

\u5bbf\u4e3b\u9632\u5fa1\u7cfb\u7edf\u7684\u57fa\u672c\u7279\u5f81\u5305\u62ec\u4f5c\u4e3a\u7b2c\u4e00\u9053\u9632\u7ebf\u7684\u5148\u5929\u7ec4\u6210\u90e8\u5206\u548c\u9700\u8981\u66f4\u957f\u65f6\u95f4\u52a8\u5458\u4f46\u5177\u6709\u7279\u5f02\u6027\u548c\u8bb0\u5fc6\u529b\u7684\u9002\u5e94\u6027\u7ec4\u6210\u90e8\u5206\u3002\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u4e24\u4e2a\u90e8\u5206\u5e76\u975e\u76f8\u4e92\u72ec\u7acb\uff0c\u800c\u4ee5\u5404\u79cd\u5173\u952e\u7684\u65b9\u5f0f\u5728\u529f\u80fd\u4e0a\u76f8\u4e92\u5173\u8054\uff0c\u5982\u901a\u8fc7\u4e00\u4e9b\u53ef\u6eb6\u6027\u7684\u6548\u5e94\u5206\u5b50\u7684\u4f5c\u7528\uff0c\u8fd9\u4e9b\u6548\u5e94\u5206\u5b50\u88ab\u79f0\u4e3a\u7ec6\u80de\u56e0\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

\u5148\u5929\u514d\u75ab<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u5148<\/span>\u5929\u514d\u75ab\u7cfb\u7edf\u5728\u5927\u591a\u6570\u751f\u7269\u4f53\u4e2d\u4ee5\u67d0\u79cd\u5f62\u5f0f\u5b58\u5728\uff0c\u5b83\u7684\u8fd0\u884c\u9075\u5faa\u51e0\u4e2a\u91cd\u8981\u539f\u5219\u3002\u9996\u5148\uff0c\u5b83\u7684\u901f\u5ea6\u5f88\u5feb\u3002\u4e0e\u9700\u8981\u51e0\u5929\u65f6\u95f4\u624d\u80fd\u52a8\u5458\u7684\u9002\u5e94\u6027\u514d\u75ab\u4e0d\u540c\uff0c\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u5404\u4e2a\u65b9\u9762\u90fd\u80fd\u975e\u5e38\u8fc5\u901f\u5730\u52a8\u5458\u8d77\u6765\u3002\u4f8b\u5982\uff0c\u541e\u566c\u7ec6\u80de-\u5c24\u5176\u662f\u9a7b\u7559\u5728\u7ec4\u7ec7\u4e2d\u7684\u5de8\u566c\u7ec6\u80de-\u5c06\u901a\u8fc7\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u68c0\u6d4b\u5165\u4fb5\u5fae\u751f\u7269\u4e0a\u7684\u7ed3\u6784\u6765\u8bc6\u522b\u611f\u67d3\u3002Toll\u6837\u53d7\u4f53(TLRs)\u662f\u5929\u7136\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\u4f7f\u7528\u7684\u4e00\u79cd\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u3002TLR\u53ef\u8bc6\u522b\u5728\u4e00\u7cfb\u5217\u5fae\u751f\u7269\u4e0a\u53d1\u73b0\u7684\u5404\u79cd\u7269\u8d28\uff0c\u4f46\u4e0d\u4f1a\u8bc6\u522b\u5bbf\u4e3b\u7ec6\u80de\u4e0a\u7684\u7269\u8d28\u3002\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u7684\u53e6\u4e00\u4e2a\u4f8b\u5b50\u662f\u8865\u4f53\u7cfb\u7edf\u7684\u7518\u9732\u805a\u7cd6\u7ed3\u5408\u51dd\u96c6\u7d20(MBL)\uff0c\u5b83\u8bc6\u522b\u7ec6\u83cc\u3001\u771f\u83cc\u548c\u75c5\u6bd2\u8868\u9762\u542b\u6709\u7518\u9732\u7cd6\u7684\u7cd6\u5206\u5b50\uff0c\u5e76\u5e2e\u52a9\u6fc0\u6d3b\u8865\u4f53\u7ea7\u8054\u53cd\u5e94\uff08\u89c1\u7b2c20\u7ae0)\u3002MBL\u4ee5\u6eb6\u6db2\u5f62\u5f0f\u5b58\u5728\u4e8e\u8840\u6d46\u4e2d\u3002\u8fd9\u79cd\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u7684\u4f7f\u7528\u662f\u5148\u5929\u7cfb\u7edf\u7684\u4e00\u4e2a\u5173\u952e\u7279\u5f81\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u5148\u5929\u7cfb\u7edf\u9664\u4e86\u5229\u7528\u8865\u4f53\u7cfb\u7edf\u7684\u8840\u6e05\u86cb\u767d\u7b49\u5206\u5b50\u5916\uff0c\u8fd8\u5229\u7528\u541e\u566c\u7ec6\u80de\uff0c\u4e3b\u8981\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\uff0c\u5b83\u4eec\u53ef\u4ee5\u76f4\u63a5\u4e0e\u67d0\u4e9b\u5fae\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u4ee5\u4fdd\u62a4\u5bbf\u4e3b\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u4e00\u4e9b\u5728\u5148\u5929\u53cd\u5e94\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u7684\u7ec6\u80de\uff0c\u5982\u81ea\u7136\u6740\u4f24(NK)\u7ec6\u80de(\u89c1\u7b2c22\u7ae0)\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7\u8bf1\u5bfc\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1(\u51cb\u4ea1)\u6765\u68c0\u6d4b\u548c\u6740\u6b7b\u67d0\u4e9b\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u3002\u53e6\u4e00\u7ec4\u91cd\u8981\u7684\u53ef\u6eb6\u6027\u5206\u5b50\u4e5f\u662f\u5929\u7136\u9632\u5fa1\u7cfb\u7edf\u7684\u4e00\u90e8\u5206\uff0c\u90a3\u5c31\u662f\u5e72\u6270\u7d20(\u89c1\u7b2c20\u7ae0)\u3002\u75c5\u6bd2\u611f\u67d3\u4f1a\u89e6\u53d1\u53d7\u611f\u67d3\u7ec6\u80de\u4ea7\u751f\u5e72\u6270\u7d20\uff0c\u5e72\u6270\u7d20\u53ef\u4ee5\u6291\u5236\u8bb8\u591a<\/span>\u75c5\u6bd2\u7684\u590d\u5236\uff0c\u5e76\u4e14\u4e0d\u662f\u75c5\u539f\u4f53\u7279\u5f02\u6027\u7684\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u8bb8\u591a\u5148\u5929\u7cfb\u7edf\u6210\u5206–\u4f8b\u5982\u8865\u4f53\u3001\u5e72\u6270\u7d20\u3001\u7ec6\u80de\u56e0\u5b50\u6216\u7ec6\u80de\uff0c\u5982\u5de8\u566c\u7ec6\u80de–\u53ef\u4ee5\u5f71\u54cd\u7279\u5b9a\u7684\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u3002\u8fd9\u662f\u53e6\u4e00\u4e2a\u91cd\u8981\u7684\u53d1\u73b0-\u5148\u5929\u7cfb\u7edf\u548c\u9002\u5e94\u6027\u7cfb\u7edf\u662f\u76f8\u4e92\u8054\u7cfb\u548c\u6709\u91cd\u5408\u7684\u3002\u9002\u5e94\u6027\u7cfb\u7edf\u901a\u5e38\u662f\u7531\u5148\u5929\u7cfb\u7edf\u89e6\u53d1\uff0c\u53ea\u6709\u5f53\u5148\u5929\u7cfb\u7edf\u672a\u80fd\u6218\u80dc\u5165\u4fb5\u7684\u5fae\u751f\u7269\uff0c\u6216\u8005\u5165\u4fb5\u7684\u5fae\u751f\u7269\u627e\u5230\u4e86\u907f\u514d\u4e0e\u5148\u5929\u7cfb\u7edf\u76f8\u4e92\u4f5c\u7528\u7684\u65b9\u6cd5\u65f6\uff0c\u9002\u5e94\u7cfb\u7edf\u624d\u4f1a\u53d1\u6325\u4f5c\u7528\u3002\u672c\u4e66\u5bf9\u5148\u5929\u7cfb\u7edf\u548c\u9002\u5e94\u6027\u7cfb\u7edf\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u75c5\u539f\u4f53\u7528\u6765\u907f\u514d\u88ab\u514d\u75ab\u7cfb\u7edf\u68c0\u6d4b\u7684\u673a\u5236\u662f\u540e\u9762\u8ba8\u8bba\u7684\u4e3b\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

\u9002\u5e94\u6027\u514d\u75ab<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf<\/span>\u9996\u6b21<\/span>\u662f\u5728\u810a\u690e\u52a8\u7269<\/span>\u8fdb\u5316\u6811\u4e2d\u89c2\u5bdf\u5230\u7684<\/span>\u3002<\/span>\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u80fd\u591f<\/span>\u7279\u5f02\u6027\u5730\u533a\u5206\u81ea\u6211\u548c\u975e\u6211\u3002<\/span>\u8fd9\u662f\u901a\u8fc7\u521b\u5efa\u5305\u542b\u7279\u5f02\u6027\u8bc6\u522b\u5206\u5b50\u7684\u9884\u671f\u9632\u5fa1\u7cfb\u7edf\u6765\u5b9e\u73b0\u7684\uff0c\u8be5\u8bc6\u522b\u5206\u5b50\u80fd\u4e0e\u5916\u6765\u7684\u975e\u6211\u6297\u539f\u76f8\u4e92\u4f5c\u7528\u3002<\/span>\u810a\u690e\u52a8\u7269\u57fa\u56e0\u7ec4\u5305\u542b\u51e0\u4e2a\u53ef\u4ee5\u7f16\u7801\u6570\u4ee5\u767e\u4e07\u8ba1\u6297\u539f\u8bc6\u522b\u5206\u5b50\u7684\u57fa\u56e0\uff0c<\/span>\u8fd9\u4e9b\u5305\u62ec\u6297\u539f\u53d7\u4f53\u5728\u5185\u7684\u57fa\u56e0\u5bb6\u65cf\u80fd\u591f\u8bc6\u522b\u4efb\u4f55\u7279\u5b9a\u7684\u6297\u539f(<\/span>Fig<\/span>2.1<\/span>)\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672a\u6210\u719f\u7684\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\u201c\u526a\u5207\u5e76\u7c98\u8d34\u201d(\u91cd\u7ec4)\u53d7\u4f53\u57fa\u56e0\u7247\u6bb5\uff0c\u4ece\u800c\u4ea7\u751f\u8fd9\u79cd\u5177\u6709\u5de8\u5927\u591a\u6837\u6027\u7684\u53d7\u4f53(\u89c1\u7b2c6\u7ae0)\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u5206\u5b50\u673a\u5236\u4f7f\u67d0\u4e9b\u53d7\u4f53(\u6216\u6297\u4f53)\u5728\u514d\u75ab\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u80fd\u591f\u5728\u4f53\u7ec6\u80de\u6c34\u5e73\u4e0a\u8fdb\u884c\u4fee\u9970\uff0c\u4ee5\u4ea7\u751f\u66f4\u5408\u9002\u7684\u53d7\u4f53\uff0c\u4e5f\u5c31\u662f\u8bf4\u4f7f\u7ed3\u5408\u66f4\u5177\u7279\u5f02\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig2.1\u4e28\u5177\u6709\u7279\u5f02\u6027\u6297\u539f\u53d7\u4f53\u7684\u6dcb\u5df4\u7ec6\u80de\u5728\u9047\u5230\u6297\u539f\u4e4b\u524d\u5c31\u5b58\u5728<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u810a\u690e\u52a8\u7269\u4ea7\u751f\u9488\u5bf9\u975e\u81ea\u6211\u5b9e\u4f53\u7684\u9884\u671f\u9632\u5fa1\u7cfb\u7edf\u7684\u80fd\u529b\u662f\u901a\u8fc7\u5728\u751f\u6b96\u7cfb\u4e2d\u590d\u5236\u8fd9\u4e9b\u57fa\u56e0\u6765\u589e\u5f3a\u7684\uff0c\u8fd9\u4e9b\u57fa\u56e0\u7f16\u7801\u7684\u86cb\u767d\u8d28\u5177\u6709\u7ed3\u5408\u4f4d\u70b9\u5e76\u53ef\u4f5c\u4e3a\u53d7\u4f53\u53d1\u6325\u529f\u80fd(Fig2.2<\/span>)\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig2.2\u4e28\u6297\u539f\u8bc6\u522b\u5206\u5b50\u548c\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u7684\u6f14\u53d8\u3002Ig\uff1a\u514d\u75ab\u7403\u86cb\u767d\uff1bMHC\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff1bTCR\uff1aT\u7ec6\u80de\u53d7\u4f53<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u8fd9\u4e9b\u57fa\u56e0\u590d\u5236\u7684\u4ea7\u7269\u662f\u7f16\u7801\u6297\u539f\u8bc6\u522b\u5206\u5b50\u7684\u57fa\u56e0\u5bb6\u65cf\uff1a\u6297\u4f53\u3001T\u7ec6\u80de\u53d7\u4f53(TCRs)\u548c\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269(MHC)\u86cb\u767d\u3002\u6bcf\u4e2a\u6dcb\u5df4\u7ec6\u80de\u90fd\u8868\u8fbe\u4e00\u4e2a\u72ec\u7279\u7684\u6297\u539f\u53d7\u4f53\uff0c\u8fd9\u662f\u7406\u89e3\u8fd9\u4e00\u7cfb\u7edf\u5982\u4f55\u5de5\u4f5c\u7684\u91cd\u8981\u4e00\u6b65\u3002\u4e00\u65e6\u6297\u539f\u9047\u5230\u643a\u5e26\u6700\u9002\u5408\u8be5\u6297\u539f\u7684\u53d7\u4f53\u7684\u6dcb\u5df4\u7ec6\u80de\uff0c\u8fd9\u4e2a\u9884\u5148\u5b58\u5728\u7684\u7ec6\u80de\u5c31\u4f1a\u5206\u88c2\u5e76\u4ea7\u751f\u8bb8\u591a\u5b50\u7ec6\u80de(\u514b\u9686)\u3002\u56e0\u6b64\uff0c\u6dcb\u5df4\u7ec6\u80de\u662f\u901a\u8fc7\u514b\u9686\u6027\u6269\u589e\u4f7f\u6297\u539f\u7279\u5f02\u6027\u53d7\u4f53\u589e\u591a\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u643a\u5e26\u6709\u67d0\u79cd\u53d7\u4f53\u7684\u6dcb\u5df4\u7ec6\u80de\u9047\u5230\u53ef\u7279\u5f02\u6027\u7ed3\u5408\u7684\u6297\u539f\u65f6\uff0c\u5148\u524d\u5b58\u5728\u7684\u6dcb\u5df4\u7ec6\u80de\u514b\u9686\u88ab\u9009\u62e9\u6027\u5730\u89e6\u53d1\uff0c\u4ee5\u4ea7\u751f\u66f4\u591a\u53ef\u4e0e\u6240\u9047\u5230\u7684\u6297\u539f\u53d1\u751f\u7cbe\u786e\u76f8\u4e92\u4f5c\u7528\u7684\u53d7\u4f53(\u89c1Fig2.1<\/span>)\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u5177\u6709\u9884\u5148\u5b58\u5728\u7684\u53d7\u4f53\u7684\u9884\u671f\u7cfb\u7edf\u7684\u4e00\u4e2a\u590d\u6742\u4e4b\u5904\u662f\u53ef\u4ee5\u4ea7\u751f\u6297\u81ea\u8eab\u7684\u53d7\u4f53(<\/span>\u89c1<\/span>Fig2.3<\/span>)\uff0c\u643a\u5e26\u8fd9\u4e9b\u6f5c\u5728\u7834\u574f\u6027\u53d7\u4f53\u7684\u7ec6\u80de\u5fc5\u987b\u88ab\u6e05\u9664\u6216\u706d\u6d3b\u3002\u5f53\u9519\u8bef\u53d1\u751f\u5e76\u4e14\u6f5c\u5728\u7684\u81ea\u4f53\u6297\u6027\u7ec6\u80de\u4fdd\u6301\u6d3b\u8dc3\u65f6\uff0c\u5c31\u53ef\u80fd\u4f1a\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u751f(\u89c1\u7b2c28\u7ae0)\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig2.3\u4e28\u81ea\u8eab\u514d\u75ab\u5e94\u7b54\u7684\u7ec6\u80de\u589e\u6b96\u8fc7\u7a0b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u8fd9\u4e2a\u7406\u89e3\u975e\u6211\u5206\u5b50\u8bc6\u522b\u548c\u54cd\u5e94\u80fd\u529b\u53d1\u5c55\u7684\u6a21\u578b\u88ab\u79f0\u4e3a\u514b\u9686\u9009\u62e9\u7406\u8bba(\u89c1Fig1.3<\/span>)\u3002\u7b2c6\u7ae0\u3001\u7b2c7\u7ae0\u3001\u7b2c14\u7ae0\u548c\u7b2c15\u7ae0\u5c06\u8fdb\u4e00\u6b65\u9610\u8ff0\u4e86\u8fd9\u4e00\u7406\u8bba\u7684\u5404\u4e2a\u65b9\u9762\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

\u514d\u75ab\u7cfb\u7edf\u7684\u7ec4\u6210\u90e8\u5206<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u4e3b\u8981\u7279\u5f81\u662f\u7279\u5f02\u6027\u3001\u591a\u6837\u6027\u548c\u8bb0\u5fc6\u6027\u3002\u5b83\u7684\u53cd\u5e94\u662f\u7279\u6b8a\u7684\uff0c\u56e0\u4e3a\u5b83\u533a\u5206\u4e0d\u540c\u7684\u5206\u5b50\u5b9e\u4f53\uff1b\u5b83\u7684\u591a\u6837\u6027\u662f\u56e0\u4e3a\u5b83\u51e0\u4e4e<\/span>\u6709\u80fd\u529b\u5bf9<\/span>\u4efb\u4f55\u53ef\u80fd\u9047\u5230\u7684\u6297\u539f\u505a\u51fa\u53cd\u5e94\uff1b<\/span>\u5b83\u5177\u6709\u8bb0\u5fc6\u6027\u662f\u56e0\u4e3a\u5b83\u53ef\u4ee5\u56de\u5fc6\u8d77\u4ee5\u524d\u4e0e\u6297\u539f\u63a5\u89e6\u7684\u60c5\u51b5\uff0c\u5e76\u5728\u7b2c\u4e8c\u6b21\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u53cd\u5e94\u3002<\/span>\u6700\u540e\u4e00\u4e2a\u7279\u5f81\u662f\u63a5\u79cd\u75ab\u82d7\u7684\u57fa\u7840\uff0c\u5982<\/span>Box2.1<\/span>\u6240\u793a\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u514d\u75ab\u7cfb\u7edf\u5229\u7528\u7ec6\u80de(Fig2.4<\/span>)\u548c\u53ef\u6eb6\u6027\u5206\u5b50\u4f5c\u4e3a\u6548\u5e94\u5668\u6765\u4fdd\u62a4\u5bbf\u4e3b\u3002\u5b83\u7531\u8bb8\u591a\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u7ec4\u6210\uff0c\u4f46\u90fd\u662f\u767d\u7ec6\u80de\uff0c\u5b83\u4eec\u4e13\u95e8\u6267\u884c\u4e0d\u540c\u7684\u529f\u80fd\u3002\u4f8b\u5982\uff0c\u541e\u566c\u7ec6\u80de\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7b49\u88ab\u7528\u6765\u975e\u7279\u5f02\u6027\u5730<\/span>\u7834\u574f\u5165\u4fb5\u7684\u5fae\u751f\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig2.4 A\u4e28\u514d\u75ab\u7cfb\u7edf\u7684\u4e3b\u8981\u7ec6\u80de\uff08\u56fa\u6709\u514d\u75ab\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig2.4 B\u4e28\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\/\u514d\u75ab\u7403\u86cb\u767d<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u6210\u719f\u7ec6\u80de\u53ef\u4ee5\u51fa\u73b0\u5728\u8840\u6db2\u6216\u7ec4\u7ec7\u4e2d\uff0c\u5982\u8840\u6db2\u4e2d\u7684\u6dcb\u5df4\u7ec6\u80de\u548c\u7ec4\u7ec7\u4e2d\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u6dcb\u5df4\u7ec6\u80de(B\u7ec6\u80de\u548cT\u7ec6\u80de)\u63d0\u4f9b\u7279\u5f02\u6027\u514d\u75ab\u3002B\u7ec6\u80de\u7684\u4ea7\u7269-\u6297\u4f53\u662f\u53ef\u6eb6\u6027\u5206\u5b50\uff0c\u6709\u65f6\u88ab\u79f0\u4e3a\u4f53\u6db2\u514d\u75ab\u7cfb\u7edf\u3002\u7ec6\u80de\u5916\u7684\u75c5\u539f\u4f53\u4e3b\u8981\u88ab\u6297\u4f53\u6e05\u9664\uff0c\u800c\u7ec6\u80de\u5185\u7684\u75c5\u539f\u4f53\u5219\u9700\u8981T\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u6765\u6e05\u9664\u3002\u4e0e\u4f53\u6db2\u514d\u75ab\u6216\u6297\u4f53\u4ecb\u5bfc\u7684\u514d\u75ab\u76f8\u6bd4\uff0cT\u7ec6\u80de\u7684\u529f\u80fd\u6709\u65f6\u88ab\u79f0\u4e3a\u7ec6\u80de\u514d\u75ab\u3002\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08Antigen-presenting cells\uff0cAPC)\uff0c\u5982\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de(\u89c1<\/span>Fig2.5<\/span>)\uff0c\u5728\u542f\u52a8B\u548cT\u7ec6\u80de\u7684\u6fc0\u6d3b\u4e2d\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig2.5\u4e28\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08\u6765\u81eaDr.Stella Knight \u7684\u7535\u955c\u626b\u63cf\u7167\u7247\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u5728\u7b2c10\u7ae0\u4e2d\u5c06\u4ecb\u7ecd\u6297\u539f\u7684\u5904\u7406\u548c\u63d0\u5448\u3002\u7b80\u800c\u8a00\u4e4b\uff0cAPC(\u5982\u5de8\u566c\u7ec6\u80de)\u5438\u6536\u6297\u539f\uff0c\u5e76\u4f7f\u5176\u5728\u7ec6\u80de\u7684\u5404\u4e2a\u9694\u5ba4\u4e2d\u53d1\u751f\u86cb\u767d\u6c34\u89e3\u964d\u89e3\u3002\u8fd9\u4e9b\u4e8b\u4ef6\u88ab\u79f0\u4e3a\u6297\u539f\u5904\u7406\uff0c\u5b83\u4eec\u662f\u5fc5\u9700\u7684\uff0c\u56e0\u4e3a\u5c3d\u7ba1B\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u53ef\u4ee5\u76f4\u63a5\u4e0e\u6297\u539f\u7ed3\u5408\uff0c\u4f46T\u7ec6\u80de\u7684\u6297\u539f<\/span>\u53d7\u4f53\u53ea\u80fd\u8bc6\u522bAPC\u8868\u9762\u63d0\u5448\u7684\u5904\u7406\u8fc7\u7684\u6297\u539f\u3002\u6297\u539f\u80bd\u7ed3\u5408\u5728MHC\u5206\u5b50\u7684\u591a\u80bd\u7ed3\u5408\u69fd\u4e2d(\u89c1\u7b2c8\u7ae0)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u4e00\u4e9b\u751f\u7269\u4f53\u8bd5\u56fe\u9003\u907f\u514d\u75ab\u7cfb\u7edf\uff0c\u4f46\u662f\u514d\u75ab\u7cfb\u7edf\u5df2\u7ecf\u53d1\u5c55\u51fa\u4e86\u4e00\u4e9b\u53cd\u51fb\u7684\u65b9\u6cd5(Box2.2<\/span>)<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

\u4e3b\u52a8\u514d\u75ab\u548c\u88ab\u52a8\u514d\u75ab<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u514d\u75ab\u53ef\u88ab\u8fdb\u4e00\u6b65\u5212\u5206\u4e3a\u4e24\u79cd\u3002\u4e3b\u52a8\u514d\u75ab\u53d1\u751f\u5728\u4e2a\u4f53\u5bf9\u6297\u539f\u8d77\u5230\u76f4\u63a5\u4f5c\u7528\u65f6–\u4f8b\u5982\uff0c\u5728\u9047\u5230\u75c5\u6bd2\u4e4b\u540e(\u89c1Box4.1<\/span>)\u3002\u8fd9\u4e0e\u88ab\u52a8\u514d\u75ab\u5f62\u6210\u5bf9\u6bd4\uff0c\u5728\u88ab\u52a8\u514d\u75ab\u4e2d\uff0c\u901a\u8fc7\u5c06\u514d\u75ab\u7ec6\u80de\u6216\u8840\u6e05\u4ece\u514d\u75ab\u4e2a\u4f53\u8f6c\u79fb\u5230\u672a\u514d\u75ab\u4e2a\u4f53\u6765\u8fbe\u5230\u514d\u75ab\u76ee\u7684(\u4f8b\u5982\uff0c\u5728\u88ab\u72d7\u54ac\u4f24\u540e\u6ce8\u5c04\u6297\u72c2\u72ac\u75c5\u6297\u4f53\uff1b\u89c1Box4.2<\/span>)\u3002\u72c2\u72ac\u75c5\u75c5\u6bd2\u7684\u6297\u4f53\u662f\u5728\u5176\u4ed6\u4e2a\u4f53\u8eab\u4e0a\u4ea7\u751f\u7684\uff0c\u4f5c\u7528\u662f\u63d0\u4f9b\u4fdd\u62a4\uff0c\u8fd9\u6bd4\u53d7\u4f24\u4e2a\u4f53\u81ea\u5df1\u5236\u9020\u5fc5\u8981\u7684\u6297\u4f53\u66f4\u5feb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

\u514d\u75ab\u5e94\u7b54\u7684\u9636\u6bb5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u4e3b\u52a8\u514d\u75ab\u5e94\u7b54\u7531\u51e0\u4e2a\u6b65\u9aa4\u6216\u9636\u6bb5\u7ec4\u6210(Fig2.6<\/span>)\u3002\u9996\u5148\u662f\u8bc6\u522b\u6297\u539f\u7684\u8bc6\u522b\u9636\u6bb5-\u6297\u539f\u4e0e\u5e26\u6709\u4e0e\u6297\u539f\u76f8\u5339\u914d\u7684\u53d7\u4f53\u7ec6\u80de\u76f8\u9047\u3002\u7136\u540e\u8fd9\u4e2a\u7ec6\u80de\u5c31\u4f1a\u88ab\u6fc0\u6d3b\u5e76\u589e\u6b96(\u89c1\u7b2c11\u7ae0)\u3002\u63a5\u7740\u4ea7\u751f\u8d8a\u6765\u8d8a\u591a\u7684\u76f8\u540c\u514b\u9686\u7ec6\u80de\uff0c\u8fd9\u662f\u6fc0\u6d3b\u9636\u6bb5\u3002\u8fd9\u4e9b\u7ec6\u80de\u4f1a\u7ecf\u5386\u5404\u79cd\u53d8\u5316\uff0c\u5373\u5206\u5316\uff0c\u4ee5\u4ea7\u751f\u5e94\u7b54\u3002\u4f8b\u5982\uff0cB\u7ec6\u80de\u7ecf\u5386\u4e86\u4e0d\u540c\u7684\u53d1\u80b2\u9636\u6bb5\u540e(\u89c1\u7b2c14\u7ae0)\u5f62\u6210\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u7ec6\u80de\uff0c\u79f0\u4e3a\u6d46\u7ec6\u80de\uff0c\u5b83\u53ef\u4ee5\u5408\u6210\u5e76\u5206\u6ccc\u5927\u91cf\u7528\u4e8e\u6e05\u9664\u6297\u539f<\/span>\u7684\u6297\u4f53\u5206\u5b50\uff0c\u8fd9\u662f\u7b2c\u4e09\u4e2a\u9636\u6bb5\uff0c\u79f0\u4e3a\u6548\u5e94\u9636\u6bb5\u3002\u4e00\u65e6\u6297\u539f\u88ab\u6e05\u9664\uff0c\u5c31\u4f1a\u91c7\u53d6\u5404\u79cd\u6b65\u9aa4\u6765\u964d\u4f4e\u5e94\u7b54\u3002\u8fd9\u4e9b\u6b65\u9aa4\u65e8\u5728\u8c03\u8282\u5e94\u7b54\uff0c\u9632\u6b62\u5e94\u7b54\u5728\u6297\u539f\u6216<\/span>\u5fae\u751f\u7269\u88ab<\/span>\u4e2d\u548c\u6216\u6d88\u9664<\/span>\u540e\u7ee7\u7eed\u8fdb\u884c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig2.6\u4e28B\u7ec6\u80de\u4ea7\u751f\u6297\u4f53\u76f8\u5173\u514d\u75ab\u5e94\u7b54\u7684\u4e09\u4e2a\u9636\u6bb5<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

\u514d\u75ab\u5e94\u7b54\u7c7b\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u5165\u4fb5\u75c5\u539f\u4f53\u53ef\u4ece\u52a8\u7269\u5b66\u4e0a\u5206\u4e3a\u75c5\u6bd2\u3001\u7ec6\u83cc\u3001\u771f\u83cc\u3001\u539f\u751f\u52a8\u7269\u6216\u8815\u866b\u3002\u4f8b\u5982\uff0c\u80a0\u9053\u6216\u547c\u5438\u7cfb\u7edf\u7684\u7ba1\u8154\u8868\u9762\u53ef\u88ab\u8815\u866b\u7684\u5165\u4fb5\uff0c\u76ae\u80a4\u8868\u9762\u53ef\u80fd\u4f1a\u53d7\u5230\u8282\u80a2\u52a8\u7269\u7684\u653b\u51fb\u3002\u7ec6\u80de\u95f4\u7684\u95f4\u9699\u53ef\u80fd\u4f1a\u88ab\u7ec6\u83cc\u6216\u771f\u83cc\u4fb5\u5165\u3002\u6b64\u5916\uff0c\u75c5\u6bd2\u3001\u4e00\u4e9b\u7ec6\u83cc\u548c\u5bc4\u751f\u866b\u751f\u6d3b\u5728\u7ec6\u80de\u5185\u3002\u4e00\u822c\u8bf4\u6765\uff0c\u514d\u75ab\u7cfb\u7edf\u7684\u7ec4\u6210\u90e8\u5206\u53ef\u4ee5\u6839\u636e\u5165\u4fb5\u75c5\u539f\u4f53\u7684\u4e0d\u540c\u6816\u606f\u5730\u4ea7\u751f\u4e09\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u514d\u75ab\u53cd\u5e94\u3002Table2.1<\/span>\u603b\u7ed3\u4e86\u8fd9\u4e09\u79cd\u7c7b\u578b\u7684\u53cd\u5e94\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e09\u79cd\u514d\u75ab\u53cd\u5e94\u90fd\u53ef\u80fd\u5bfc\u81f4\u975e\u5e38\u5e38\u89c1\u75be\u75c5\u3002\u968f\u7740\u5b66\u4e60\u7684<\/span>\u6df1\u5165<\/span>\uff0c\u4f60\u4f1a\u8bfb\u5230\u66f4\u591a\u5173\u4e8e\u8fd9\u4e09\u79cd\u7c7b\u578b\u5e94\u7b54\u7684\u76f8\u5173\u5185\u5bb9\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n

Table2.1<\/span>\u514d\u75ab\u5e94\u7b54\u7684\u8bf8\u591a\u7c7b\u578b<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n

BOX2.1<\/strong>\u4e59\u809d\u75ab\u82d7<\/span><\/p>\n<\/section>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n

\u4e59\u578b\u809d\u708e\u75c5\u6bd2(HBV)\u611f\u67d3\u53ef\u5bfc\u81f4\u77ed\u671f\u75be\u75c5\uff0c\u5982\u5178\u578b\u7684\u9ec4\u75b8\uff0c\u6216\u6162\u6027\u75be\u75c5\u5982\u809d\u786c\u5316\u3001\u809d\u764c\uff0c\u6216\u6b7b\u4ea1\u3002\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u7ea6\u6709125\u4e07\u4eba\u60a3\u6709\u6162\u6027\u4e59\u578b\u809d\u708e\uff0c\u7ea65000\u4eba\u6b7b\u4e8e\u6b64\u75c5\u3002\u540c\u6837\uff0cHBV\u901a\u8fc7\u63a5\u89e6\u611f\u67d3\u8005\u7684\u4f53\u6db2\u4f20\u64ad\u3002\u6709\u4e00\u79cd\u75ab\u82d7\u662f\u7531\u9175\u6bcd\u7ec6\u80de\u4e2d\u7684\u8d28\u7c92\u8868\u8fbe\u800c\u6210\u7684\u91cd\u7ec4\u86cb\u767d(\u4e59\u809d\u8868\u9762\u6297\u539f[HBsAg])\u3002\u5728\u75ab\u82d7\u4e2d\uff0c\u91cd\u7ec4\u7684HBsAg\u86cb\u767d\u81ea\u7ec4\u88c5\u6210\u75c5\u6bd2\u6837\u9897\u7c92(VLPs)\u3002\u5728\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u4e2d\uff0cVLP\u7c7b\u4f3c\u4e8eHBV\uff0c\u4f46\u5b83\u4eec\u4e0d\u542b\u75c5\u6bd2\u57fa\u56e0\uff0c\u4e5f\u4e0d\u80fd\u7e41\u6b96\u3002<\/p>\n

    \u5178\u578b\u7684\u75ab\u82d7\u63a5\u79cd\u8ba1\u5212\u662f\u4e09\u6b21\u808c\u8089\u6ce8\u5c04\uff0c\u901a\u5e38\u5728\u51fa\u751f\u65f6\u30011\u4e2a\u6708\u548c2\u4e2a\u6708\u65f6\u6ce8\u5c04\u3002\u5bf9\u4e8e\u9ad8\u5371\u4eba\u7fa4\uff0c\u5982\u533b\u79d1\u5b66\u751f\uff0c\u5728\u63a5\u79cd\u75ab\u82d7\u540e\u62bd\u53d6\u8840\u6db2\u6837\u672c\uff0c\u4ee5\u786e\u4fdd\u75ab\u82d7\u63a5\u53d7\u8005\u7684\u8840\u6db2\u4e2d\u5b58\u5728\u8db3\u591f\u7684HBsAg\u6297\u4f53\u3002\u5fc5\u987b\u670910mIU\/mL\u7684HBsAg\u6297\u4f53\u624d\u80fd\u8d77\u5230\u4fdd\u62a4\u4f5c\u7528\u3002Fig2.7\u5c55\u793a\u4e86\u4e09\u5242\u91cf\u75ab\u82d7\u5728\u4f53\u5185\u5f15\u8d77\u7684\u6297\u4f53\u542b\u91cf\u53d8\u5316\u7684\u66f2\u7ebf\u56fe\u3002\u5982\u679c\u4e00\u4e2a\u4eba\u4f53\u5185\u6ca1\u670910mIU\/mL\u6216\u66f4\u591a\u7684HBsAg\u6297\u4f53\uff0c\u5c31\u9700\u8981\u91cd\u590d\u63a5\u79cd\u75ab\u82d7\u3002<\/p>\n

     Fig2.7\u8fd8\u8bf4\u660e\u4e86\u521d\u6b21\u66b4\u9732\u548c\u4e8c\u6b21\u66b4\u9732\u6216\u968f\u540e\u66b4\u9732\u4e8e\u6297\u539f\u65f6\u6297\u4f53\u53cd\u5e94\u7684\u5dee\u5f02\u3002\u6700\u521d\uff0c\u521d\u7ea7\u53cd\u5e94\u76f8\u5bf9\u8f83\u6162\uff0c\u6c34\u5e73\u8f83\u4f4e\u3002\u5728\u968f\u540e\u7684\u514d\u75ab\u4e2d\uff0c\u53cd\u5e94\u66f4\u5feb\uff0c\u5e45\u5ea6\u66f4\u5927\u3002<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n

BOX2.2 <\/strong>\u5982\u4f55\u5bf9\u4ed8\u72e1\u733e\u7684\u75c5\u539f\u4f53<\/span><\/p>\n<\/section>\n

\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n

\u5fae\u751f\u7269\u4ee5\u591a\u79cd\u65b9\u5f0f\u8fdb\u5316\u4ee5\u9003\u907f\u514d\u75ab\u7cfb\u7edf\uff0c\u800c\u514d\u75ab\u7cfb\u7edf\u4e5f\u540c\u6837<\/span>\u53d1\u5c55\u51fa\u591a\u79cd\u65b9\u5f0f\u6765\u53cd\u51fb\u3002\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u5305\u62ec\u4e24\u7c7b\u7ec6\u80de\uff0c\u5b83\u4eec\u53ef\u4ee5\u5bf9\u6297\u7279\u6b8a\u7c7b\u578b\u7684\u9003\u907f\u673a\u5236\u3002<\/p>\n

     \u5bc4\u751f\u866b\u5df2\u7ecf\u9002\u5e94\u4e86\u5bc4\u4e3b\u5185\u90e8\u7684\u7c98\u819c\u8868\u9762\uff0c\u5c24\u5176\u662f\u80a0\u9053\u3002\u8fd9\u4e9b\u8868\u9762\u662f\u8bb8\u591a\u514d\u75ab\u7cfb\u7edf\u673a\u5236\u65e0\u6cd5\u89e6\u53ca\u7684\uff0c\u800c\u4e14\u8fd9\u79cd\u5927\u578b\u7684\u591a\u7ec6\u80de\u8815\u866b\u5f88\u96be\u653b\u51fb\u3002\u80a5\u5927\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\uff0c\u5b83\u4eec\u5b58\u5728\u4e8e\u7c98\u819c\u8868\u9762\u6216\u88ab\u62db\u52df\u5230\u7c98\u819c\u8868\u9762\uff0c\u80fd\u591f\u8bc6\u522b\u8815\u866b\u3002\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u5b83\u4eec\u523a\u6fc0\u4e86\u53d7\u5f71\u54cd\u5668\u5b98\u7684\u7c98\u6db2\u5206\u6ccc\u548c\u5e73\u6ed1\u808c\u6536\u7f29\uff0c\u4e8e\u662f\u8815\u866b\u5931\u53bb\u4e86\u6293\u5730\u529b\uff0c\u800c\u88ab\u5bbf\u4e3b\u9a71\u9010\u3002<\/p>\n

     \u6b64\u5916\uff0c\u4e00\u4e9b\u75c5\u6bd2\u8fdb\u5316\u51fa\u4e86\u9003\u907fT\u7ec6\u80de\u8bc6\u522b\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u673a\u5236\u3002\u4f8b\u5982\uff0c\u75b1\u75b9\u75c5\u6bd2\u53ef\u4ee5\u6291\u5236\u611f\u67d3\u7ec6\u80de\u4e2d\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\u5206\u5b50\u7684\u8868\u8fbe\u3002\u56e0\u4e3aT\u7ec6\u80de\u4f7f\u7528MHC\u5206\u5b50\u6765\u68c0\u6d4b\u6297\u539f\uff0c\u6240\u4ee5\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\u53ef\u80fd\u65e0\u6cd5\u8bc6\u522b\u3002\u81ea\u7136\u6740\u4f24(NK)\u7ec6\u5219\u8fdb\u5316\u5230\u80fd\u591f\u68c0\u6d4b\u7ec6\u80de\u4e0aMHC\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u5982\u679c\u7ec6\u80de\u4e0aMHC\u7684\u8868\u8fbe\u51cf\u5c11\uff0cNK\u7ec6\u80de\u5c31\u80fd\u591f\u6740\u6b7b\u8be5\u7ec6\u80de\u3002\u56e0\u6b64\uff0cNK\u7ec6\u6b64\u6709\u52a9\u4e8e\u514b\u670d\u75b1\u75b9\u75c5\u6bd2\u7684\u514d\u75ab\u9003\u907f\u673a\u5236\u3002<\/p>\n

     \u80a5\u5927\u7ec6\u80de\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u548cNK\u7ec6\u80de\u90fd\u5c06\u5728\u7b2c22\u7ae0\u8be6\u7ec6\u63cf\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/section>\n

<\/section>\n

\u2014 THE  END \u2014<\/span><\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |<\/span> \u6731\u6e05\u8f69 \u90d1\u68a6\u6021 \u848b\u4fca\u535a<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> <\/span>\u949f\u96ea\u83b9<\/span><\/span><\/section>\n
\u5ba1\u6838 |  \u738b\u5764 \u5b8b\u4e50<\/span><\/section>\n

<\/span><\/section>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a><\/p>\n

\n
\n
\n
\n
PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/section>\n
Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a>
<\/section>\n
BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/section>\n
\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/section>\n
\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/span><\/a>
<\/section>\n
\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/span><\/a>
<\/section>\n
Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/span><\/a>
<\/section>\n
\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/span><\/a>
<\/section>\n
PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/span><\/a>
<\/section>\n
\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/span><\/a>
<\/section>\n
\u5982\u4f55\u6d4b\u91cfWestern Blot\u6761\u5e26\u7070\u5ea6\u503c\uff1f(GelPro\u8f6f\u4ef6\u4f7f\u7528\u65b9\u6cd5)<\/span><\/a>
<\/section>\n

\u5b9e\u9a8c\u4e2d\u5982\u4f55\u6311\u9009\u5230\u4e00\u652f\u597d\u7528\u7684\u6297\u4f53\uff1f<\/a><\/span><\/p>\n


<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/p>\n

\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u83b7\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u626b\u63cf\u4e8c\u7ef4\u7801\u52a0\u5165\u514d\u75ab\u4ea4\u6d41\u7fa4~<\/span><\/p>\n


<\/p>\n

\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bbf\u4e3b\u9632\u5fa1\u7cfb\u7edf\u7684\u57fa\u672c\u7279\u5f81\u5305\u62ec\u4f5c\u4e3a\u7b2c\u4e00\u9053\u9632\u7ebf\u7684\u5148\u5929\u7ec4\u6210\u90e8\u5206\u548c\u9700\u8981\u66f4\u957f\u65f6\u95f4\u52a8\u5458\u4f46\u5177\u6709\u7279\u5f02\u6027\u548c\u8bb0\u5fc6\u529b\u7684\u9002\u5e94\u6027\u7ec4\u6210\u90e8\u5206\u3002\u5982\u4e0a\u56fe\u6240\u793a\uff0c\u4e24\u4e2a\u90e8\u5206\u5e76\u975e\u76f8\u4e92\u72ec\u7acb\uff0c\u800c\u4ee5\u5404\u79cd\u5173\u952e\u7684\u65b9\u5f0f\u5728\u529f\u80fd\u4e0a\u76f8\u4e92\u5173\u8054\uff0c…<\/p>\n","protected":false},"author":1,"featured_media":2706,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[58],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3482"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3482"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3482\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/2706"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3482"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}