{"id":3494,"date":"2021-04-14T22:51:39","date_gmt":"2021-04-14T14:51:39","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2021\/04\/14\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac11%e7%ab%a0%ef%bc%9a%e6%b7%8b%e5%b7%b4%e7%bb%86%e8%83%9e%e6%b4%bb%e5%8c%96\/"},"modified":"2021-04-14T22:51:39","modified_gmt":"2021-04-14T14:51:39","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac11%e7%ab%a0%ef%bc%9a%e6%b7%8b%e5%b7%b4%e7%bb%86%e8%83%9e%e6%b4%bb%e5%8c%96","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2021\/04\/14\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac11%e7%ab%a0%ef%bc%9a%e6%b7%8b%e5%b7%b4%e7%bb%86%e8%83%9e%e6%b4%bb%e5%8c%96\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316"},"content":{"rendered":"
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B\u7ec6\u80de\u548cT\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u662f\u7ec6\u80de\u8868\u9762\u591a\u5206\u5b50\u86cb\u767d\u8d28\u590d\u5408\u7269\u7684\u4e00\u90e8\u5206(T\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u5728\u7b2c7\u7ae0<\/span>\u63cf\u8ff0\u8fc7\uff0cB\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u5728\u7b2c4\u7ae0<\/span>\u548c\u7b2c5\u7ae0<\/span>\u63cf\u8ff0\u8fc7)\u3002\u5c3d\u7ba1\u819c\u7ed3\u5408\u514d\u75ab\u7403\u86cb\u767d(Ig)\u548c\u03b1\u03b2(\u6216\u03b3\u03b4)T\u7ec6\u80de\u53d7\u4f53(TCR)\u90fd\u6709\u8de8\u8d8a\u7ec6\u80de\u819c\u5e76\u5ef6\u4f38\u5230\u7ec6\u80de\u8d28\u7684\u86cb\u767d\u8d28\u94fe\uff0c\u4f46\u5b83\u4eec\u7684\u7ec6\u80de\u8d28\u5e8f\u5217\u90fd\u5f88\u77ed\u3002\u8fd9\u4e9b\u77ed\u5c0f\u7684\u7ec6\u80de\u8d28\u201c\u5c3e\u5df4\u201d\u5728\u4e0e\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u7684\u7ec6\u80de\u5185\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u65f6\u662f\u65e0\u6548\u7684\u3002\u56e0\u6b64\uff0c\u5176\u4ed6\u86cb\u767d\u8d28\u5fc5\u987b\u4e0e\u201c\u53d7\u4f53\u201d\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u624d\u80fd\u53d1\u6325\u6709\u6548\u7684\u4fe1\u53f7\u8f6c\u5bfc\u3002\u5728\u529f\u80fd\u4e0a\uff0cB\u7ec6\u80de\u53d7\u4f53(BCR)\u548cTCR\u90fd\u662f\u591a\u5206\u5b50\u86cb\u767d\u8d28\u590d\u5408\u4f53\uff0c\u5176\u4e2d\u5176\u4ed6\u51e0\u79cd\u86cb\u767d\u8d28\u4e0e\u7ec6\u80de\u8868\u819c\u4e0a\u7684\u6297\u539f\u53d7\u4f53\u86cb\u767d\u975e\u5171\u4ef7\u8fde\u63a5\u5728\u4e00\u8d77\u3002BCR\u548cTCR\u590d\u5408\u4f53\u7684\u4e3b\u8981\u86cb\u767d\u8d28\u6210\u5206\u5982Fig11.1<\/span>\u548cFig11.2<\/span>\u6240\u793a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig11.1<\/span> B\u7ec6\u80de\u53d7\u4f53\u591a\u5206\u5b50\u590d\u5408\u7269\u7684\u7ed3\u6784<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 11.2<\/span> T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u591a\u5206\u5b50\u590d\u5408\u7269\u7684\u7ed3\u6784<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ece\u529f\u80fd\u4e0a\uff0cBCR\u662f\u7531\u819c\u7ed3\u5408\u514d\u75ab\u7403\u86cb\u767d(mlg)\u548c\u4e24\u79cd\u4e0d\u53d8\u86cb\u767dIg\u03b1\u548cIg\u03b2\u7ec4\u6210\u7684\u590d\u5408\u4f53\u3002\u5982Fig11.1<\/span>\u6240\u793a\uff0cIg\u03b1\u548cIg\u03b2\u4ee5\u4e8c\u786b\u952e\u8fde\u63a5\u7684\u5f02\u4e8c\u805a\u4f53\u7684\u5f62\u5f0f\u4e0emIg\u7ed3\u5408\u3002Ig\u03b1-Ig\u03b2\u5f02\u6e90\u4e8c\u805a\u4f53\u662fmIg\u5728\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u548c\u4fe1\u53f7\u8f6c\u5bfc\u6240\u5fc5\u9700\u7684\u3002Ig\u03b1\u548cIg\u03b2\u7684\u80de\u5185\u533a\u8db3\u591f\u5927\uff0c\u53ef\u4ee5\u4e0e\u7ec6\u80de\u4fe1\u53f7\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u3002Ig\u03b1\u548cIg\u03b2\u90fd\u542b\u6709\u5728\u51e0\u4e2a\u53d7\u4f53\u5206\u5b50\u4e2d\u53d1\u73b0\u7684\u5e8f\u5217\uff0c\u5305\u62ec\u88ab\u79f0\u4e3a\u514d\u75ab\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u6d3b\u57fa\u5e8f(ITAM)\u7684TCR\u590d\u5408\u4f53\u7684\u86cb\u767d\u8d28\u3002ITAM\u5728B\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u4fe1\u53f7\u8f6c\u5bfc\u4e2d\u90fd\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002ITAM\u5e8f\u5217\u542b\u6709\u916a\u6c28\u9178\uff0c\u5728\u7ec6\u80de\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\u88ab\u916a\u6c28\u9178\u6fc0\u9176(PTKs)\u78f7\u9178\u5316\u3002\u7136\u540e\uff0c\u78f7\u9178\u5316\u7684ITAM\u4e0e\u7ec6\u80de\u8d28\u4fe1\u53f7\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0cITAM\u5c06\u6fc0\u6d3b\u4fe1\u53f7\u4ece\u7ec6\u80de\u8868\u9762\u4f20\u9012\u5230\u7ec6\u80de\u8d28\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u529f\u80fd\u4e0a\uff0cTCR\u590d\u5408\u7269\u7531TCR\u03b1\u03b2(\u6216\u03b3\u03b4)\u94fe\u548c\u5176\u4ed6\u516d\u79cd\u53c2\u4e0e\u4fe1\u53f7\u8f6c\u5bfc\u7684\u86cb\u767d\u8d28\u94fe\u7ec4\u6210\u3002TCR\u03b1\u03b2(\u6216\u03b3\u03b4)\u94fe\u4e0eAPC\u4e0a\u7684MHC-\u6297\u539f\u590d\u5408\u4f53\u7ed3\u5408\uff0c\u4f46\u5b83\u4e0d\u80fd\u5355\u72ec\u6709\u6548\u5730\u5411T\u7ec6\u80de\u53d1\u51fa\u7ed3\u5408\u6297\u539f\u7684\u4fe1\u53f7\u3002\u8fd9\u9700\u8981\u901a\u8fc7\u4e0e\u8f85\u52a9\u86cb\u767d\u94feCD3\u548c\u03b6(zeta)\u5408\u4f5c\u5b9e\u73b0\u3002CD3\u75314\u6761\u94fe\u7ec4\u6210\uff0c\u03b3\u94fe\u548c\u03b4\u94fe\u54041\u6761\uff0c\u03b5\u94fe2\u6761\u3002TCR\u590d\u5408\u4f53\u4e2d\u67092\u4e2a\u03b6\u94fe(\u89c1Fig11.2<\/span>)\u3002CD3\u548c\u03b6\u94fe\u90fd\u6709\u5927\u91cf\u542b\u6709ITAM\u7684\u80de\u5185\u533a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u6fc0\u6d3b\u6709\u51e0\u4e2a\u6761\u4ef6\u3002\u5bf9\u4e8e\u7b2c\u4e00\u4fe1\u53f7\uff0c\u53d7\u4f53\u590d\u5408\u4f53\u5fc5\u987b\u805a\u96c6\u5728\u4e00\u8d77\u3002\u5bf9\u4e8eB\u7ec6\u80de\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u591a\u805a\u6297\u539f\u4f7f\u53d7\u4f53\u5206\u5b50\u4ea4\u8054\u800c\u53d1\u751f\u3002\u4f46\u8fd9\u79cd\u60c5\u51b5\u5728\u53ef\u6eb6\u6027\u86cb\u767d\u6297\u539f\u4e2d\u5f88\u5c11\u53d1\u751f\uff0c\u4e00\u822c\u8fd8\u9700\u8981\u5176\u4ed6\u8868\u9762\u5206\u5b50\u53c2\u4e0e\u6765\u589e\u5f3a\u4fe1\u53f7\u4f20\u9012(\u89c1\u540e\u6587)\u3002B\u548cT\u7ec6\u80de\u90fd\u9700\u8981\u7b2c\u4e8c\u4e2a\u4fe1\u53f7\u624d\u80fd\u6fc0\u6d3b\u3002\u8fd9\u4e9b\u88ab\u79f0\u4e3a\u5171\u523a\u6fc0\u4fe1\u53f7(costimulatory signals<\/em>)\u7684\u7b2c\u4e8c\u79cd\u4fe1\u53f7\u7684\u6027\u8d28\u5c06\u5728\u7b2c16\u7ae0<\/span>\u4e2d\u4ecb\u7ecd\uff0c\u540c\u65f6\u8fd8\u5c06\u4ecb\u7ecdB\u7ec6\u80de\u548cT\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u66f4\u591a\u7ec6\u8282\u3002\u5176\u4ed6\u88ab\u79f0\u4e3a\u5171\u53d7\u4f53\u5206\u5b50(coreceptor molecules<\/em>)\u7684\u7ec6\u80de\u8868\u9762\u5206\u5b50\u4e5f\u53c2\u4e0e\u4e86\u4e3b\u8981\u4fe1\u53f7\u7684\u4f20\u9012\u3002\u5171\u53d7\u4f53\u5206\u5b50\u5728B\u7ec6\u80de\u548cT\u7ec6\u80de\u6fc0\u6d3b\u4e2d\u7684\u4f5c\u7528\u5c06\u5728\u540e\u9762\u89e3\u91ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TCR\u7684\u805a\u96c6\u6d89\u53caTCR\u4e0eAPC\u4e0a\u7684MHC-\u6297\u539f\u590d\u5408\u7269\u7ed3\u5408\u3002\u4f3c\u4e4e\u53ea\u5360\u7528\u51e0\u767e\u4e2aTCRs\u5c31\u8db3\u4ee5\u542f\u52a8\u4e00\u4e2a\u4e3b\u6fc0\u6d3b\u4fe1\u53f7\u3002\u540c\u6837\uff0cT\u7ec6\u80de\u6fc0\u6d3b\u9700\u8981APC\u63d0\u4f9b\u7684\u7b2c\u4e8c\u4e2a\u5171\u523a\u6fc0\u4fe1\u53f7\u3002\u4e0eB\u7ec6\u80de\u4e00\u6837\uff0c\u5171\u53d7\u4f53\u5206\u5b50\u6709\u52a9\u4e8eT\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002CD4\u548cCD8\u5728T\u7ec6\u80de\u4e0a\u8d77\u5171\u53d7\u4f53\u5206\u5b50\u7684\u4f5c\u7528\u3002\u4ed6\u4eec\u7684\u4f5c\u7528\u4e5f\u5c06\u5728\u540e\u9762\u8fdb\u4e00\u6b65\u8ba8\u8bba\u3002\u6700\u540e\uff0c\u6240\u8c13\u7684\u8f85\u52a9\u5206\u5b50(accessory molecules<\/em>)\u4fc3\u8fdbT\u7ec6\u80de-APC\u7684\u63a5\u89e6\u548cTCR-MHC-\u80bd\u7684\u7ed3\u5408\u3002\u8fd9\u4e9b\u8f85\u52a9\u5206\u5b50\u4e3b\u8981\u662f\u4e00\u4e9b\u9ecf\u9644\u5206\u5b50\uff0c\u5982T\u7ec6\u80de\u8868\u9762\u7684CD11a\u6216\u767d\u7ec6\u80de\u529f\u80fd\u76f8\u5173\u6297\u539f1(LFA-1)\uff0c\u5b83\u4eec\u53ef\u4ee5\u4e0eAPC\u4e0a\u7684CD54\u6216\u7ec6\u80de\u95f4\u9ecf\u9644\u5206\u5b501(ICAM-1)\u7ed3\u5408\u3002\u8fd9\u4e9b\u9ecf\u9644\u5206\u5b50\u5c06\u5728\u7b2c13\u7ae0<\/span>\u8fdb\u4e00\u6b65\u8ba8\u8bba\u3002T\u7ec6\u80de\u53d7\u4f53-MHC\u3001\u5171\u53d7\u4f53\u5206\u5b50\u548c\u9ecf\u9644\u5206\u5b50\u4e00\u8d77\u5728APC\u548cT\u7ec6\u80de\u4e4b\u95f4\u5f62\u6210\u514d\u75ab\u7a81\u89e6(\u89c1Fig7.8<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5171\u53d7\u4f53\u5206\u5b50\u5728B\u7ec6\u80de\u6fc0\u6d3b\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u524d\u6240\u8ff0\uff0c\u5982\u679c\u6ca1\u6709Ig\u03b1\/Ig\u03b2\u548cCD3\u7b49\u86cb\u767d\u7684\u5e2e\u52a9\uff0cB\u7ec6\u80de\u548cT\u7ec6\u80de\u4e0a\u7684\u6297\u539f\u7279\u5f02\u6027\u53d7\u4f53\u5c31\u65e0\u6cd5\u4f20\u9012\u4fe1\u53f7\u3002\u7136\u800c\uff0c\u6700\u4f73\u7684\u4fe1\u53f7\u4f20\u9012\u9700\u8981\u66f4\u591a\u7684\u7ec6\u80de\u8868\u9762\u5206\u5b50\u6210\u4e3a\u5171\u53d7\u4f53\u5206\u5b50\u3002B\u7ec6\u80de\u5171\u53d7\u4f53\u5206\u5b50(Fig11.3<\/span>)\u53ef\u4ee5\u4e0eBCR\u805a\u96c6\u5230\u4e00\u8d77\uff0c\u4f7f\u5f97\u4fe1\u53f7\u4f20\u9012\u6548\u7387\u63d0\u9ad8\u6570\u5343\u500d\u3002\u5982Fig11.3<\/span>\u6240\u793a\uff0cB\u7ec6\u80de\u5171\u53d7\u4f53\u7531\u4e09\u79cd\u86cb\u767d\u8d28\u7ec4\u6210:CD21\uff0c\u4e5f\u79f0\u4e3a\u8865\u4f53\u53d7\u4f532(CR2), CD19\u548cCD81\u3002\u4e0e\u8865\u4f53\u6210\u5206C3d\u7ed3\u5408\u7684\u86cb\u767d\u8d28\u6297\u539f(\u89c1\u7b2c20\u7ae0<\/span>)\u53ef\u4ee5\u540c\u65f6\u4e0eCD21\u548cBCR\u7ed3\u5408\u3002CD21-CD19-CD81\u5171\u53d7\u4f53\u590d\u5408\u7269\u80fd\u591f\u4e0eBCR\u805a\u96c6\u548c\u4ea4\u8054\uff0c\u5e76\u8bf1\u5bfcCD19\u7ec6\u80de\u5185\u5c3e\u90e8\u7684\u78f7\u9178\u5316\u53cd\u5e94\u3002\u8fd9\u79cd\u78f7\u9178\u5316\u4f7f\u5c5e\u4e8e\u7c7b\u4f3c\u9176\u5bb6\u65cf(Src\u5bb6\u65cf)\u7684PTKs\u80fd\u591f\u4e0eCD19\u7684\u7ec6\u80de\u8d28\u5c3e\u90e8\u7ed3\u5408\uff0c\u589e\u52a0BCR\u5468\u56f4\u4fe1\u53f7\u5206\u5b50\u7684\u6d53\u5ea6\uff0c\u4ece\u800c\u63d0\u9ad8\u4fe1\u53f7\u4f20\u5bfc\u7684\u6548\u7387(\u89c1Fig11.3<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 11.3<\/span> B\u7ec6\u80de\u53d7\u4f53-\u5171\u53d7\u4f53\u590d\u5408\u7269<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5171\u53d7\u4f53\u5206\u5b50\u5728T\u7ec6\u80de\u6fc0\u6d3b\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u53ea\u6709\u5f53\u5171\u53d7\u4f53\u5206\u5b50\u53c2\u4e0e\u65f6\uff0c\u624d\u80fd\u901a\u8fc7TCR\u53d1\u51fa\u6700\u4f73\u7684\u6fc0\u6d3b\u4fe1\u53f7\u3002TCR\u5171\u53d7\u4f53\u5206\u5b50\u4e3aCD4\u548cCD8(Fig11.4<\/span>)\u3002\u6b63\u5982\u7b2c7\u7ae0<\/span>\u548c\u7b2c10\u7ae0<\/span>\u6240\u8ba8\u8bba\u7684\uff0cCD4\u4e0eMHC II\u7c7b\u5206\u5b50\u7ed3\u5408\uff0cCD8\u4e0eMHC I\u7c7b\u5206\u5b50\u7ed3\u5408\u3002\u4f8b\u5982\uff0c\u5f53TCR\u4e0eAPC\u4e0a\u7684MHC II\u7c7b\u591a\u80bd\u590d\u5408\u7269\u7ed3\u5408\u65f6\uff0cT\u7ec6\u80de\u4e0a\u7684CD4\u4e0eMHC II\u7c7b\u5206\u5b50\u7ed3\u5408(Fig11.6<\/span>)\u3002\u916a\u6c28\u9178\u6fc0\u9176Lck\u662f\u4e00\u79cdSrc\u6fc0\u9176\uff0c\u4e0eCD4(\u548cCD8)\u7684\u80de\u6d46\u7ed3\u6784\u57df\u76f8\u5173\u3002\u56e0\u6b64\uff0c\u5f53CD4\u4e0eMHC II-\u591a\u80bd\u590d\u5408\u7269\u7ed3\u5408\u6216CD8\u4e0eMHC I-\u591a\u80bd\u590d\u5408\u7269\u7ed3\u5408\u65f6\uff0cLck\u4e5f\u4f1a\u5b9a\u4f4d\u4e8eTCR\u590d\u5408\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 11.4<\/span> T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09-\u5171\u53d7\u4f53\u590d\u5408\u7269<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Lck\u5728T\u7ec6\u80de\u7684\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\u4e2d\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\uff0c\u800c\u4e14\u5171\u53d7\u4f53\u5206\u5b50\u7684\u53c2\u4e0e\u589e\u52a0\u4e86\u8fd9\u4e9b\u4fe1\u53f7\u5206\u5b50\u5728TCR\u9644\u8fd1\u7684\u96c6\u4e2d\u3002\u636e\u4f30\u8ba1\uff0cCD4\u6216CD8\u5171\u53d7\u4f53\u7684\u5b58\u5728\u53ef\u4ee5\u5c06\u89e6\u53d1T\u7ec6\u80de\u53cd\u5e94\u6240\u9700\u7684MHC-\u80bd\u590d\u5408\u7269\u7684\u6570\u91cf\u51cf\u5c11\u7ea6\u767e\u500d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4fe1\u53f7\u4f20\u5bfc\u673a\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u5185\u5206\u5b50\uff0c\u4e3b\u8981\u662f PTKs\u548c\u86cb\u767d\u916a\u6c28\u9178\u78f7\u9178\u9176(PTPs)\uff0c\u5f62\u6210\u53d7\u4f53\u6fc0\u6d3b\u548c\u751f\u5316\u901a\u8def\u6fc0\u6d3b\u95f4\u7684\u8054\u7cfb\uff0c\u653e\u5927\u548c\u4f20\u9012\u4fe1\u53f7\u3002\u5728\u4e0eBCR\u4ea4\u8054\u7684\u51e0\u79d2\u949f\u5185\uff0cSrc\u5bb6\u65cf\u7684PTK\u9176(Box11.1<\/span>\uff09<\/span>\u4f7f\u53d7\u4f53\u86cb\u767d\u80de\u8d28\u5c3e\u90e8\u7684ITAM\u78f7\u9178\u5316(Fig11.5<\/span>)\u3002\u53d7\u4f53\u5c3e\u90e8\u7684\u78f7\u9178\u5316\u5c06\u5176\u4ed6\u4fe1\u53f7\u5206\u5b50\u5438\u5f15\u5230\u53d7\u4f53\u7684\u7ec6\u80de\u8d28\u4e00\u4fa7\u3002\u5728B\u7ec6\u80de\u4e2d\uff0c\u5173\u952e\u5206\u5b50\u662f\u53e6\u4e00\u79cd\u88ab\u79f0\u4e3aSyk\u7684PTKs\uff0c\u5b83\u4e0eIg\u03b1\u548cIg\u03b2\u4e2d\u78f7\u9178\u5316\u7684ITAM\u5e8f\u5217\u7ed3\u5408\uff0c\u7136\u540e\u81ea\u8eab\u88ab\u78f7\u9178\u5316\u6fc0\u6d3b\u3002Syk\u53ef\u80fd\u88ab\u4e0eBCR\u76f8\u5173\u7684Src\u5bb6\u65cf\u6fc0\u9176\u78f7\u9178\u5316\uff0c\u5982Fig11.5<\/span>\u6240\u793a\uff0c\u4e5f\u53ef\u80fd\u88ab\u4e0e\u76f8\u90bbBCR\u94fe\u7ed3\u5408\u7684\u53e6\u4e00\u4e2aSyk\u5206\u5b50\u78f7\u9178\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 11.5<\/span> \u6700\u65e9\u7684B\u7ec6\u80de\u6d3b\u5316\u4e8b\u4ef6<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u7cfb\u5217\u76f8\u5173\u6b65\u9aa4\u53d1\u751f\u5728T\u7ec6\u80de\u4e2d\u3002TCR\u3001CD3\u548cCD4\/CD8\u86cb\u767d\u5bf9APC\u4e0aMHC-\u591a\u80bd\u7684\u8bc6\u522b\u4f5c\u7528\u5c06Lck\u5e26\u5165\u53d7\u4f53\u590d\u5408\u4f53(\u89c1Fig11.6<\/span>)\u3002Lck\u4f7fCD3\u548c\u03b6\u94fe\u80de\u8d28\u5e8f\u5217\u4e2d\u7684ITAM\u78f7\u9178\u5316\u3002\u8fd9\u5438\u5f15\u4e86PTK  ZAP-70\uff0cPTK  ZAP-70\u662fT\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24(NK)\u7ec6\u80de\u6240\u72ec\u6709\u7684\u3002ZAP-70\u4e0eSyk\u5c5e\u4e8e\u540c\u4e00\u4e2aPTK\u5bb6\u65cf\uff0c\u5e76\u4e0e\u03be\u94fe\u4e0a\u7684ITAM\u7ed3\u5408\u3002\u6bcf\u4e2a\u03b6\u94fe\u6709\u591a\u4e2aITAM\uff0c\u56e0\u6b64\u53ef\u80fd\u6709\u4e0d\u6b62\u4e00\u4e2aZAP-70\u5206\u5b50\u4e0e\u03b6\u94fe\u7ed3\u5408(\u89c1Fig11.6<\/span>)\u3002\u7136\u540eZAP-70\u88abLck\u78f7\u9178\u5316\uff0c\u78f7\u9178\u5316\u6fc0\u6d3b\u4e86ZAP-70\u7684PTK\u6d3b\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u65e6\u5728B\u6216T\u7ec6\u80de\u4e2d\u5206\u522b\u6fc0\u6d3b\u4e86\u5173\u952e\u6570\u91cf\u7684Syk\u6216ZAP-70\u6fc0\u9176\uff0c\u4fe1\u53f7\u5c31\u4f1a\u4ece\u7ec6\u80de\u819c\u5411\u524d\u4f20\u9012\uff0c\u5e76\u901a\u8fc7\u51e0\u6761\u9014\u5f84\u7684\u6fc0\u6d3b\u800c\u88ab\u653e\u5927\u3002\u5f53\u5b58\u5728\u5f71\u54cdPTK\u529f\u80fd\u7684\u7a81\u53d8\u65f6\uff0c\u5c06\u4f1a\u53d1\u751f\u514d\u75ab\u7f3a\u9677\uff0c\u8fd9\u4e5f\u8868\u660e\u4e86PTKs\u5728\u6dcb\u5df4\u7ec6\u80de\u529f\u80fd\u4e2d\u7684\u91cd\u8981\u4f5c\u7528(Box 11.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6fc0\u6d3b\u4fe1\u53f7\u7684\u653e\u5927<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4fe1\u53f7\u4ece\u7ec6\u80de\u819c\u4f20\u64ad\u5230\u7ec6\u80de\u6838\uff0c\u5728\u90a3\u91cc\u5b83\u53ef\u4ee5\u5bf9\u7ec6\u80de\u53cd\u5e94\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\uff0c\u8fd9\u6d89\u53ca\u5230\u51e0\u79cd\u751f\u5316\u9014\u5f84\uff0c\u8fd9\u4e9b\u9014\u5f84\u5728B\u548cT\u7ec6\u80de\u4e2d\u7c7b\u4f3c\uff0c\u5728\u4f20\u64ad\u4fe1\u53f7\u7684\u540c\u65f6\u53ef\u4ee5\u653e\u5927\u4fe1\u53f7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728B\u7ec6\u80de\u548cT\u7ec6\u80de\u4e2d\uff0c\u6709\u4e09\u6761\u4e3b\u8981\u7684\u4fe1\u53f7\u901a\u8def\u3002\u7b2c\u4e00\u4e2a\u6d89\u53ca\u78f7\u8102\u9176C\u03b3(PLC-\u03b3)\u7684\u78f7\u9178\u5316\u548c\u6fc0\u6d3b\u3002\u8fd9\u662f\u7531Syk\u6216ZAP-70\u89e6\u53d1\u7684(Fig11.7<\/span>\u548cFig11.8<\/span>)\u3002\u6fc0\u6d3b\u7684PLC-\u03b3\u968f\u540e\u6fc0\u6d3b\u4e24\u6761\u901a\u8def\uff0c\u5305\u62ec\u4e8c\u9170\u57fa\u7518\u6cb9(DAG)\u548c\u86cb\u767d\u6fc0\u9176C\uff0c\u4ee5\u53ca1\uff0c4\uff0c5-\u4e09\u78f7\u9178\u808c\u9187(IP3)\u548c\u4e1d\u6c28\u9178-\u82cf\u6c28\u9178\u7279\u5f02\u6027\u7684\u86cb\u767d\u78f7\u9178\u9176-\u9499\u8c03\u795e\u7ecf\u78f7\u9178\u9176(Calcineurin)\u3002\u7b2c\u4e09\u6761\u4e3b\u8981\u9014\u5f84\u6d89\u53caSyk\u6216ZAP-70\u6fc0\u6d3b\u9002\u914d\u86cb\u767d\uff0c\u7136\u540e\u6fc0\u6d3b\u5355\u94fe\u9e1f\u82f7\u4e09\u78f7\u9178(GTP)\u7ed3\u5408\u86cb\u767d(\u5982Ras)\u3002\u7136\u540e\uff0cRas\u86cb\u767d\u5bb6\u65cf\u6fc0\u6d3b\u4fe1\u53f7\u901a\u8def\uff0c\u76f4\u63a5\u901a\u8fc7\u4e1d\u88c2\u539f\u6fc0\u6d3b\u86cb\u767d(MAP)\u6fc0\u9176\u6fc0\u6d3b\u8f6c\u5f55\u56e0\u5b50(\u53c2\u89c1Fig11.7<\/span>\u548cFig11.8<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728B\u7ec6\u80de\u4e2d\uff0cSyk\u4f7fPLC-\u03b3\u78f7\u9178\u5316(\u89c1Fig11.7<\/span>)\uff0c\u5728T\u7ec6\u80de\u4e2d\uff0cZAP-70\u4f7fPLC-\u03b3\u78f7\u9178\u5316(\u89c1Fig11.8<\/span>)\u3002\u5bfc\u81f4PLC-\u03b3\u8fc1\u79fb\u5230\u7ec6\u80de\u819c\u4e0a\uff0c\u5728\u7ec6\u80de\u819c\u4e0a\u50ac\u5316\u78f7\u8102\u9170\u808c\u91874\uff0c5-\u4e8c\u78f7\u9178(PIP2<\/sub>)\u7684\u88c2\u89e3\u751f\u6210DAG\u548cIP3<\/sub>\u3002\u540e\u8005\u5bfc\u81f4\u80de\u6d46\u9499\u79bb\u5b50\u6c34\u5e73\u5347\u9ad8\uff0c\u4ece\u800c\u6fc0\u6d3b\u51e0\u79cd\u9499\u4f9d\u8d56\u6027\u9176\uff0c\u5305\u62ecCalcineurin\uff0c\u5b83\u8d1f\u8d23\u53bb\u78f7\u9178\u5316NF-AT\u5bb6\u65cf\u8f6c\u5f55\u56e0\u5b50\u3002\u5c3d\u7ba1\u540d\u4e3aNF-AT\uff0c\u4f46\u5b83\u662fT\u548cB\u7ec6\u80de\u8868\u8fbe\u7ec6\u80de\u56e0\u5b50\u57fa\u56e0\u90fd\u6240\u5fc5\u9700\u7684\u3002\u4e1d\u6c28\u9178-\u82cf\u6c28\u9178\u6fc0\u9176C\u901a\u8fc7\u4e0e\u8131\u6c27\u6838\u7cd6\u6838\u9178\u76f8\u4e92\u4f5c\u7528\u800c\u88ab\u6fc0\u6d3b\uff0c\u5e76\u78f7\u9178\u5316\u51e0\u79cd\u7ec6\u80de\u86cb\u767d\uff0c\u6700\u7ec8\u5bfc\u81f4\u5305\u62ec\u6838\u56e0\u5b50\u03baB(NF-\u03baB)\u5728\u5185\u7684\u8f6c\u5f55\u56e0\u5b50\u7684\u6fc0\u6d3b\u3002\u7b2c\u4e09\u4e2a\u4fe1\u53f7\u901a\u8def\u6d89\u53caRas\u5bb6\u65cf\u7684\u5c0fGTP\u7ed3\u5408\u86cb\u767d\u7684\u6fc0\u6d3b\u3002\u8fd9\u4e9b\u4fe1\u53f7\u5206\u5b50\u901a\u8fc7\u6fc0\u6d3bMAP\u6fc0\u9176\u5bb6\u65cf\u53d1\u6325\u4f5c\u7528\uff0c\u8fd9\u4e9b\u9176\u6fc0\u6d3b\u51e0\u79cd\u8f6c\u5f55\u56e0\u5b50\uff0c\u5305\u62ec\u4e00\u79cd\u540d\u4e3a\u6fc0\u6d3b\u86cb\u767d1(activation protein 1<\/em>, AP-1)\u7684\u8f6c\u5f55\u56e0\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 11.6<\/span>  T\u7ec6\u80de\u6d3b\u5316\u7684\u6700\u65e9\u4e8b\u4ef6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 11.7<\/span>  B\u7ec6\u80de\u4e2d\u7684\u4e3b\u8981\u4fe1\u53f7\u901a\u8def<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 11.8  T\u7ec6\u80de\u4e2d\u7684\u4e3b\u8981\u4fe1\u53f7\u901a\u8def<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u5e94\u7b54<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0d\u540c\u7684\u8f6c\u5f55\u56e0\u5b50-\u5305\u62ecNF-AT\u3001NF-\u03baB\u548cAP-1-\u4f5c\u7528\u4e8e\u51e0\u4e2a\u6dcb\u5df4\u7ec6\u80de\u57fa\u56e0\u6765\u589e\u5f3a\u5b83\u4eec\u7684\u8f6c\u5f55\u3002\u8fd9\u4e3aT\u548cB\u7ec6\u80de\u7684\u589e\u6b96\u548c\u5206\u5316\u505a\u597d\u4e86\u51c6\u5907\u3002\u7ec6\u80de\u589e\u6b96\u9700\u8981\u5feb\u901f\u5408\u6210\u6838\u82f7\u9178\uff0c\u624d\u80fd\u4ea7\u751f\u65b0\u7684DNA\u3002\u8fd9\u4e5f\u662f\u4e00\u79cd\u514d\u75ab\u6291\u5236\u836f\u7269\u7684\u4f5c\u7528\u9014\u5f84\u3002\u5728B\u7ec6\u80de\u4e2d\uff0c\u514d\u75ab\u7403\u86cb\u767d\u7684\u5206\u6ccc\u53ef\u80fd\u662f\u7ec6\u80de\u6fc0\u6d3b\u7684\u7ed3\u679c\u3002\u5728T\u7ec6\u80de\u4e2d\uff0c\u6fc0\u6d3b\u5bfc\u81f4\u7ec6\u80de\u56e0\u5b50\u7684\u8868\u8fbe\u589e\u5f3a\uff0c\u5982\u767d\u7ec6\u80de\u4ecb\u7d202(IL-2)\uff0c\u5b83\u662f\u6709\u6548\u7684T\u7ec6\u80de\u53cd\u5e94\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u662fT\u7ec6\u80de\u7684\u751f\u957f\u56e0\u5b50\u3002\u514d\u75ab\u6291\u5236\u836f\u7269\u53ef\u4ee5\u8c03\u8282\u8fd9\u79cd\u53cd\u5e94(Box11.3<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u4fdd\u6301\u5185\u7a33\u6001\uff0c\u5fc5\u987b\u8c03\u8282\u5e76\u7ec8\u6b62T\u7ec6\u80de\u7684\u53cd\u5e94\uff0c\u5c3d\u7ba1\u8fd9\u662f\u5982\u4f55\u5b9e\u73b0\u7684\u8fd8\u4e0d\u5b8c\u5168\u4e86\u89e3\u3002\u5f53\u7136\uff0c\u968f\u7740\u6297\u539f(\u75c5\u539f\u4f53)\u88ab\u6210\u529f\u6e05\u9664\uff0c\u523a\u6fc0\u6e90\u4e5f\u88ab\u79fb\u9664\uff0cT\u7ec6\u80de\u7684\u53cd\u5e94\u4e5f\u4f1a\u51cf\u5f31\u3002\u7ec6\u80de\u51cb\u4ea1\u6216\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1(\u89c1\u7b2c17\u7ae0<\/span>)\uff0c\u662f\u4e00\u79cd\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u80fd\u6709\u52a9\u4e8e\u7ec8\u6b62T\u7ec6\u80de\u53cd\u5e94\u7684\u673a\u5236\u3002\u6b64\u5916\uff0c\u5982\u679cT\u7ec6\u80de\u4e0d\u80fd\u63a5\u6536\u5230\u5171\u523a\u6fc0\u4fe1\u53f7(\u4f8b\u5982CD28\u548cCD80\uff1b\u89c1\u7b2c16\u7ae0<\/span>)\uff0c\u5b83\u4eec\u5c31\u4f1a\u8fdb\u5165\u4e00\u79cd\u65e0\u529f\u80fd\u6027\u65e0\u53cd\u5e94\u7684\u72b6\u6001\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 11.1 <\/span>\u7ec6\u80de\u5185\u4fe1\u53f7\u8f6c\u5bfc\uff1a\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u9176\u548c\u86cb\u767d\u916a\u6c28\u9178\u78f7\u9178\u9176\u7684\u4f5c\u7528<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u78f7\u9178\u5316\u662f\u7ec6\u80de\u8c03\u8282\u86cb\u767d\u8d28\u6d3b\u6027\u7684\u5e38\u89c1\u751f\u5316\u673a\u5236\u3002\u86cb\u767d\u6fc0\u9176\u901a\u8fc7\u5728\u86cb\u767d\u8d28\u4e2d\u6dfb\u52a0\u78f7\u9178\u57fa\u56e2\u6765\u5f71\u54cd\u86cb\u767d\u8d28\u7684\u529f\u80fd\u3002\u8fd9\u4e9b\u78f7\u9178\u57fa\u56e2\u901a\u8fc7\u916a\u6c28\u9178\u6fc0\u9176(\u5982ZAP-70)\u52a0\u5230\u916a\u6c28\u9178\u6b8b\u57fa\u4e0a\uff0c\u901a\u8fc7\u4e1d\u6c28\u9178-\u82cf\u6c28\u9178\u6fc0\u9176(\u5982\u86cb\u767d\u6fc0\u9176C)\u52a0\u5230\u4e1d\u6c28\u9178\u6216\u82cf\u6c28\u9178\u6b8b\u57fa\u4e0a\u3002\u78f7\u9178\u57fa\u56e2\u53ef\u88ab\u86cb\u767d\u78f7\u9178\u9176\u53bb\u9664\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u78f7\u9178\u5316\u6fc0\u6d3b\u9176\u7684\u6d3b\u6027\uff0c\u800c\u53bb\u78f7\u9178\u5316\u5931\u6d3b\u9176\u3002<\/p>\n

\u6709\u51e0\u79cd\u86cb\u767d\u6fc0\u9176\u5728\u6dcb\u5df4\u7ec6\u80de\u7684\u4fe1\u53f7\u8f6c\u5bfc\u4e2d\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\uff0c\u8ba4\u8bc6\u5176\u4e2d\u4e00\u4e9b\u91cd\u8981\u7684\u6fc0\u9176\u662f\u975e\u5e38\u5fc5\u8981\u7684\u3002\u4f8b\u5982\uff0cSrc(\u201cSark\u201d)\u5bb6\u65cf\u7684\u53d7\u4f53\u76f8\u5173\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6fc0\u6d3b\u4f1a\u901a\u77e5B\u548cT\u6dcb\u5df4\u7ec6\u80de\u5185\u90e8\u6297\u539f\u53d7\u4f53\u5df2\u88ab\u5360\u7528\u3002\u6dcb\u5df4\u7ec6\u80de\u4e2d\u4e3b\u8981\u7684\u4e24\u79cdSrc\u5bb6\u65cf\u6fc0\u9176\u5206\u522b\u547d\u540d\u4e3aLyn\u548cLck\u3002\u53e6\u4e00\u4e2a\u5728\u6dcb\u5df4\u7ec6\u80de\u4e2d\u7279\u522b\u91cd\u8981\u7684\u916a\u6c28\u9178\u6fc0\u9176\u5bb6\u65cf\u662fSyk\u5bb6\u65cf\u3002\u8fd9\u4e2a\u5bb6\u65cf\u6709\u4e24\u4e2a\u6210\u5458\uff0cSyk\u548cZAP-70\u3002<\/p>\n

\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5982Lyn\u548cLck\uff0c\u5f80\u5f80\u5728\u4fe1\u53f7\u901a\u8def\u7684\u65e9\u671f\u88ab\u6fc0\u6d3b\uff0c\u800c\u4e1d\u6c28\u9178-\u82cf\u6c28\u9178\u6fc0\u9176\uff0c\u5982\u86cb\u767d\u6fc0\u9176C\u548c\u9499\u8c03\u795e\u7ecf\u78f7\u9178\u9176\uff0c\u5f80\u5f80\u5728\u4fe1\u53f7\u901a\u8def\u7684\u540e\u671f\u9636\u6bb5\u8d77\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 11.2<\/span> \u514d\u75ab\u7f3a\u9677\u75be\u75c5\u4e0e\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u9176<\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u4e00\u540d10\u4e2a\u6708\u5927\u7684\u7537\u5a74\u51fa\u73b0\u53cd\u590d\u611f\u67d3\u3002\u81ea6\u4e2a\u6708\u5927\u4ee5\u6765\uff0c\u4ed6\u5df2\u7ecf\u4e24\u6b21\u60a3\u4e0a\u80ba\u708e\uff0c\u6700\u8fd1\u8fd8\u60a3\u4e0a\u4e86\u8111\u819c\u708e\uff0c\u54e5\u54e5\u548c\u53d4\u53d4\u6b7b\u4e8e\u611f\u67d3\u3002\u68c0\u67e5\u7ed3\u679c\u63d0\u793a\u4ed6\u6ca1\u6709\u514d\u75ab\u7403\u86cb\u767d\u4e5f\u6ca1\u6709B\u7ec6\u80de\u3002\u57fa\u56e0\u68c0\u6d4b\u663e\u793a\u4ed6\u7684\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176(BTK)\u57fa\u56e0\u53d1\u751f\u4e86\u7a81\u53d8\u3002\u8fd9\u79cd\u7c7b\u578b\u7684\u7a81\u53d8\u4f1a\u5bfc\u81f4X\u8fde\u9501\u6297\u4f53\u7f3a\u4e4f\u75c7\u3002\u643a\u5e26\u8fd9\u79cd\u7a81\u53d8\u7684\u7537\u5b69\u5927\u7ea6\u57286\u4e2a\u6708\u5927\u7684\u65f6\u5019\u51fa\u73b0\u75c7\u72b6\uff0c\u8fd9\u4e5f\u662f\u80ce\u513f\u671f\u7a7f\u8fc7\u80ce\u76d8\u7684\u6765\u81ea\u4e8e\u6bcd\u4f53\u7684\u514d\u75ab\u7403\u86cb\u767dG(IgG)\u8017\u5c3d\u7684\u65f6\u95f4\u6bb5\u3002\u7528\u514d\u75ab\u7403\u86cb\u767d\u6cbb\u7597\u53ef\u4ee5\u9884\u9632\u8fd9\u4e9b\u611f\u67d3\u3002Fig11.<\/span>9<\/span>\u663e\u793a\u4e00\u4f8bBTK\u9176\u7f3a\u4e4f\u75c7\u60a3\u8005\u63a5\u53d7\u514d\u75ab\u7403\u86cb\u767d\u66ff\u4ee3\u6cbb\u7597\uff0c\u6bcf3\u5468\u9759\u8109\u6ce8\u5c04\u3002\u8fd9\u6837\u7684\u6cbb\u7597\u6709\u52a9\u4e8e\u786e\u4fdd\u5065\u5eb7\u7684\u751f\u6d3b\u3002    <\/span><\/p>\n

\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u9176(PTK)\u5728\u6dcb\u5df4\u7ec6\u80de\u529f\u80fd\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u88ab\u7f16\u7801\u8fd9\u4e9b\u9176(BTK)\u7684\u57fa\u56e0\u7a81\u53d8\u3002<\/p>\n

BTK\u7f3a\u9677\u5bfc\u81f4\u4e00\u79cd\u88ab\u79f0\u4e3aX\u8fde\u9501\u65e0\u4e19\u79cd\u7403\u86cb\u767d\u8840\u75c7\u7684\u75be\u75c5\uff0c\u5728\u8fd9\u79cd\u75be\u75c5\u4e2d\uff0c\u6240\u6709\u7c7b\u522b\u7684\u514d\u75ab\u7403\u86cb\u767d\u90fd\u4e25\u91cd\u8870\u7aed\uff0c\u5e76\u4e14\u65e0\u5faa\u73afB\u7ec6\u80de\u5b58\u5728\u3002BTK\u5728\u524dB\u7ec6\u80de\u7684BCR\u4fe1\u53f7\u8f6c\u5bfc\u8fc7\u7a0b\u4e2d\u53c2\u4e0e\u808c\u9187\u78f7\u8102\u7684\u6c34\u89e3\uff0cBTK\u7684\u7f3a\u9677\u5bfc\u81f4B\u7ec6\u80de\u53d1\u80b2\u53d7\u635f\uff0c\u4ece\u800c\u963b\u788d\u6b63\u5e38\u6297\u4f53\u7684\u4ea7\u751f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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Fig 11.9<\/span> BTK\u7f3a\u9677\u7684\u60a3\u8005\u5bfc\u81f4X\u8fde\u9501\u6027\u4e19\u79cd\u7403\u86cb\u767d\u7f3a\u4e4f\u75c7<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 11.3 <\/span>\u514d\u75ab\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236<\/span><\/p>\n<\/section>\n<\/section>\n

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\u4e00\u540d29\u5c81\u7684\u5973\u6027\u57287\u5e74\u524d\u88ab\u8bca\u65ad\u4e3a\u5fc3\u808c\u75c5\u3002\u76ee\u524d\u8fd8\u6ca1\u6709\u9488\u5bf9\u5979\u7684\u7279\u6548\u836f\uff0c\u5176\u5fc3\u529b\u8870\u7aed\u6b63\u5728\u6076\u5316\u3002\u5728\u8fc7\u53bb\u7684\u4e09\u4e2a\u6708\u91cc\uff0c\u5979\u4e00\u76f4\u5728\u7b49\u5f85\u5fc3\u810f\u79fb\u690d\u3002\u4e00\u65e6\u4ece\u6350\u8d60\u8005\u90a3\u91cc\u83b7\u5f97\u4e86\u5fc3\u810f\uff0c\u5979\u5c31\u4f1a\u63a5\u53d7\u79fb\u690d\u624b\u672f\u3002\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f(HLA)\u914d\u578b(\u7b2c34\u7ae0<\/span>)\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\u901a\u5e38\u662f\u4e0d\u73b0\u5b9e\u7684\uff0c\u56e0\u4e3a\u5fc3\u810f\u79fb\u690d\u63a5\u53d7\u8005\u4e0d\u80fd\u7b49\u5f85\u4e00\u4e2a\u597d\u7684HLA\u914d\u578b\uff0c\u5fc5\u987b\u63a5\u53d7\u53ef\u7528\u914d\u578b\u3002\u5979\u5728\u79fb\u690d\u540e\u7acb\u5373\u63a5\u53d7\u4e86\u4e09\u79cd\u514d\u75ab\u6291\u5236\u836f\u7269\u7684\u8054\u5408\u6cbb\u7597\uff0c\u5e76\u5728\u5979\u7684\u4f59\u751f\u4e2d\u4e00\u76f4\u670d\u7528\u8fd9\u4e9b\u836f\u7269\u3002   <\/p>\n

\u51e0\u79cd\u514d\u75ab\u6291\u5236\u836f\u7269\u7528\u4e8e\u9884\u9632\u540c\u79cd\u5f02\u4f53\u79fb\u690d\u6392\u65a5\u53cd\u5e94(\u7b2c34\u7ae0<\/span>)\u3002\u8fd9\u4e9b\u836f\u7269\u7ed9\u79fb\u690d\u624b\u672f\u9886\u57df\u5e26\u6765\u4e86\u9769\u547d\u6027\u7684\u53d8\u5316\u3002\u5b83\u4eec\u7684\u4f7f\u7528\u62ef\u6551\u4e86\u6210\u5343\u4e0a\u4e07\u7684\u751f\u547d\uff0c\u4f7f\u5668\u5b98\u79fb\u690d\u53d8\u5f97\u201c\u53ef\u884c\u201d\uff0c\u5373\u4f7f\u5728\u6ca1\u6709\u5b8c\u7f8e\u7684HLA\u914d\u578b\u7684\u60c5\u51b5\u4e0b\u3002\u5728\u7f8e\u56fd\uff0c\u8d85\u8fc710\u4e07\u4eba\u5c06\u7ec8\u8eab\u670d\u7528\u8fd9\u4e9b\u836f\u7269\u3002\u6240\u6709\u8fd9\u4e9b\u836f\u7269\u90fd\u53ef\u4ee5\u9632\u6b62\u79fb\u690d\u7269\u6392\u65a5\u53cd\u5e94\uff0c\u4f46\u7f3a\u70b9\u662f\u60a3\u8005\u5bb9\u6613\u611f\u67d3\u4f20\u67d3\u75c5\uff0c\u56e0\u4e3a\u514d\u75ab\u53cd\u5e94\u88ab\u6291\u5236\u4e86\u3002    <\/p>\n

\u73af\u5b62\u7d20\u548c\u4ed6\u514b\u83ab\u53f8\u5747\u901a\u8fc7\u6291\u5236\u6d3b\u5316T\u7ec6\u80de\u6838\u56e0\u5b50(NF-AT)\u4ecb\u5bfc\u7684T\u7ec6\u80de\u56e0\u5b50\u57fa\u56e0\u8f6c\u5f55\u53d1\u6325\u4f5c\u7528\u3002\u5b83\u4eec\u901a\u8fc7\u4e0e\u7ec6\u80de\u8d28\u86cb\u767d\u5f62\u6210\u4e00\u79cd\u53eb\u505a\u514d\u75ab\u4eb2\u548c\u7d20\u7684\u590d\u5408\u4f53\u6765\u5b9e\u73b0\u8fd9\u4e00\u70b9\u3002\u836f\u7269-\u514d\u75ab\u4eb2\u548c\u7d20\u590d\u5408\u4f53\u6291\u5236\u9499\u8c03\u795e\u7ecf\u78f7\u9178\u9176(Calcineurin)\u7684\u4f5c\u7528(\u89c1Fig11.8<\/span>)\u3002\u5982\u679c\u6ca1\u6709\u9499\u8c03\u795e\u7ecf\u78f7\u9178\u9176\u4ecb\u5bfc\u7684\u53bb\u78f7\u9178\u5316\u53cd\u5e94\uff0cNF-AT\u5c31\u65e0\u6cd5\u8fdb\u5165\u7ec6\u80de\u6838\u4fc3\u8fdb\u57fa\u56e0\u8f6c\u5f55\uff0c\u5982\u767d\u7ec6\u80de\u4ecb\u7d202(IL-2)\u57fa\u56e0\u7684\u8f6c\u5f55\u3002\u5728\u7f3a\u4e4f\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u7684\u60c5\u51b5\u4e0b\uff0c\u6dcb\u5df4\u7ec6\u80de\u589e\u6b96\u53d7\u5230\u6291\u5236\uff0c\u514d\u75ab\u53cd\u5e94\u4e5f\u53d7\u5230\u6291\u5236\u3002<\/p>\n

\u53e6\u5916\u4e24\u79cd\u836f\u7269\u53ef\u6291\u5236IL-2\u5bf9T\u7ec6\u80de\u7684\u4f5c\u7528\u3002\u8fd9\u610f\u5473\u7740\uff0c\u5373\u4f7f\u4ea7\u751f\u4e86IL-2\uff0c\u5bf9\u79fb\u690d\u7269\u6709\u5e94\u7b54\u7684T\u7ec6\u80de(\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\u662f\u4f9b\u8005\u5fc3\u810f)\u7684\u6570\u91cf\u4e5f\u4e0d\u80fd\u589e\u957f\u3002\u897f\u7f57\u83ab\u53f8(\u96f7\u5e15\u9709\u7d20)\u662f\u4e00\u79cd\u53e3\u670d\u836f\u7269\uff0c\u53ef\u4ee5\u963b\u65adIL-2\u7684\u4f5c\u7528\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5df4\u5229\u6614\u5355\u6297(basiliximab)\u662f\u4e00\u79cd\u53ef\u4ee5\u963b\u6b62IL-2\u53d7\u4f53\u53d1\u6325\u4f5c\u7528\u7684\u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n

\u6291\u5236\u6838\u82f7\u9178\u5408\u6210\u7684\u836f\u7269\u4e5f\u53ef\u4ee5\u963b\u6b62T\u7ec6\u80de\u7684\u589e\u6b96\u3002\u786b\u5511\u560c\u5464(Azathioprine)\u6291\u5236\u560c\u5464\u7684\u5408\u6210\u3002\u56e0\u4e3a\u5b83\u5728\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u4e2d\u90fd\u5f88\u6d3b\u8dc3\uff0c\u6240\u4ee5\u53ef\u80fd\u4f1a\u6709\u526f\u4f5c\u7528\u3002\u9709\u915a\u9178\u916f(Mycophenolate mofetil)\u662f\u9e1f\u560c\u5464\u5408\u6210\u7684\u6291\u5236\u5242\u3002\u5b83\u4e3b\u8981\u6d3b\u8dc3\u5728\u6dcb\u5df4\u7ec6\u80de\u4e2d\uff0c\u56e0\u6b64\u526f\u4f5c\u7528\u6bd4\u786b\u5511\u560c\u5464\u5c0f\u3002        <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/p>\n


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\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |  \u9648\u6653\u610f \u90d1\u68a6\u6021 \u7f57\u4f73\u4f73<\/span><\/span><\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u7f57\u6e05\u7075<\/span><\/span><\/section>\n
\u5ba1\u6838 |  \u738b\u5764 \u5b8b\u4e50<\/span><\/section>\n

     
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\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

<\/a>\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/span><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/span><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a><\/span><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/section>\n
\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/section>\n
GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/section>\n
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BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/section>\n
\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a><\/span><\/section>\n
\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/span><\/a>
<\/section>\n
PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/span><\/a>
<\/section>\n
\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/span><\/a>
<\/section>\n
\u5982\u4f55\u6d4b\u91cfWestern Blot\u6761\u5e26\u7070\u5ea6\u503c\uff1f(GelPro\u8f6f\u4ef6\u4f7f\u7528\u65b9\u6cd5)<\/span><\/a>
<\/section>\n
\u5b9e\u9a8c\u4e2d\u5982\u4f55\u6311\u9009\u5230\u4e00\u652f\u597d\u7528\u7684\u6297\u4f53\uff1f<\/a><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u5728\u611f\u67d3\u7684\u65e9\u671f\u53cd\u5e94\u4e2d\uff0c\u5148\u5929\u514d\u75ab\u548c\u9002\u5e94\u6027\u514d\u75ab\u53ef\u540c\u65f6\u53d1\u751f\u4f5c\u7528\u3002\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u901a\u8fc7\u4ea7\u751f\u5371\u9669\u4fe1\u53f7\u4f5c\u51fa\u53cd\u5e94\uff0c\u800c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u901a\u8fc7\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u4f5c\u51fa\u53cd\u5e94\u3002\u6297\u539f\u4e0e\u53d7\u4f53\u7ed3\u5408\u53ef\u542f\u52a8\u4fdd\u62a4\u6027\u53cd\u5e94\u3002\u672c\u7ae0…<\/p>\n","protected":false},"author":1,"featured_media":3483,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[58],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3494"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3494"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3494\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3483"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3494"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}