{"id":3538,"date":"2021-05-24T13:56:15","date_gmt":"2021-05-24T05:56:15","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2021\/05\/24\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac15%e7%ab%a0%ef%bc%9at%e7%bb%86%e8%83%9e%e7%9a%84%e5%8f%91%e8%82%b2\/"},"modified":"2021-05-24T13:56:15","modified_gmt":"2021-05-24T05:56:15","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac15%e7%ab%a0%ef%bc%9at%e7%bb%86%e8%83%9e%e7%9a%84%e5%8f%91%e8%82%b2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2021\/05\/24\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac15%e7%ab%a0%ef%bc%9at%e7%bb%86%e8%83%9e%e7%9a%84%e5%8f%91%e8%82%b2\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2"},"content":{"rendered":"
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T\u6dcb\u5df4\u7ec6\u80de\u5728\u80f8\u817a\u4e2d\u4ea7\u751f\uff0c\u5176\u53d1\u80b2\u6d89\u53ca\u591a\u4e2a\u6b65\u9aa4\u5e76\u4f9d\u8d56\u4e8e\u51e0\u4e2a\u5185\u7f6e\u68c0\u67e5\u70b9\u6765\u786e\u4fddT\u7ec6\u80de\u7684\u6b63\u5e38\u5206\u5316\u3002\u5728\u5efa\u7acbT\u6dcb\u5df4\u7ec6\u80de\u5e93\u7684\u8fc7\u7a0b\u4e2d\uff0c\u53ea\u6709\u5c0f\u90e8\u5206\u7956T\u7ec6\u80de\uff08\u80f8\u817a\u7ec6\u80de\uff09\u53d1\u80b2\u4e3a\u6210\u719fT\u7ec6\u80de\u8fdb\u5165\u5916\u5468\u8840\u6db2\u548c\u5916\u5468\u6dcb\u5df4\u7ec4\u7ec7\uff1b\u5176\u4f59\u5927\u90e8\u5206\u7956T\u7ec6\u80de(>98%)\u5728\u9009\u62e9\u7684\u8fc7\u7a0b\u4e2d\u6b7b\u4ea1\u3002\u80f8\u817a\u7684\u9009\u62e9\u8fc7\u7a0b\u4f7f\u673a\u4f53\u80fd\u591f\u5f62\u6210\u5177\u6709\u81ea\u8eab\u8010\u53d7\u4f46\u53c8\u81ea\u6211\u9650\u5236\u7684T\u6dcb\u5df4\u7ec6\u80de\u5e93(\u7b2c\u516b\u7ae0<\/span>)\u3002\u8fd9\u610f\u5473\u7740\u88ab\u9009\u62e9\u540e\u53d1\u80b2\u6210\u719f\u7684T\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u4e0e\u81ea\u8eabMHC\u5206\u5b50\u7ed3\u5408\u7684\u975e\u81ea\u8eab\u6297\u539f\u80bd\uff0c\u4e14\u901a\u5e38\u4e0d\u8bc6\u522b\u81ea\u8eab\u591a\u80bd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7b2c13\u7ae0<\/span>\u4ecb\u7ecd\u4e86\u80f8\u817a\u7684\u7ed3\u6784\uff0c\u80f8\u817a\u5206\u4e3a\u4e09\u4e2a\u4e3b\u8981\u533a\u57df\uff1a\u88ab\u819c\u4e0b\u533a\u3001\u76ae\u8d28\u5c42\u548c\u9ad3\u8d28(Fig. 15.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 15.1<\/span> \u80f8\u817a\u7ec4\u7ec7\u7684\u7b80\u5316\u793a\u610f\u56fe\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 15.2<\/span> \u80f8\u817a\u7ec6\u80de\u6210\u719f\u7684\u4e0d\u540c\u9014\u5f84\u6982\u8ff0\u3002<\/span><\/p>\n

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\u7136\u800c\uff0c\u5927\u591a\u6570DN\u7ec6\u80de\u8868\u8fbeTCR\u03b2\u94fe\u3002\u4e00\u65e6\u6709\u529f\u80fd\u7684TCR\u03b2\u94fe\u5728\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff0c\u5b83\u5c31\u4e0e\u6052\u5b9a\u7684pre-T\u03b1\u94fe\u548cCD3\u5206\u5b50(\u7b2c7\u7ae0\u300111\u7ae0<\/span>)\u7edc\u5408\uff0c\u5f62\u6210Pre-TCR\u590d\u5408\u4f53(\u7b2c7\u7ae0\u300111\u7ae0)<\/span>\u3002pre-TCR(TCR\u524d\u4f53\uff09\u7684\u8868\u8fbe\u53ef\u4fc3\u4f7f\u4fe1\u53f7\u8f6c\u5bfc\u7684(\u7b2c11\u7ae0<\/span>)\uff0c\u6765\u81eapre-TCR\u7684\u4fe1\u53f7\u53ef\u963b\u6b62\u03b2\u94fe\u8fdb\u4e00\u6b65\u91cd\u6392\uff0c\u5e76\u4f7f\u5f97DP T\u7ec6\u80de\u589e\u6b96\u3002\u91cd\u7ec4\u9176\u8868\u8fbe\u540e\uff0c\u7ec6\u80de\u7684\u589e\u6b96\u8fdb\u4e00\u6b65\u4fc3\u8fdbTCR \u03b1\u94fe\u91cd\u6392\u3002\u56e0\u6b64\uff0c\u4e0epre-B\u7ec6\u80de\u53d7\u4f53\u7684\u4f5c\u7528\u7c7b\u4f3c(\u7b2c14\u7ae0<\/span>)\uff0cpre-T\u7ec6\u80de\u53d7\u4f53\u7684\u8868\u8fbe\u662f\u03b1\u03b2TCR\u7ec4\u88c5\u548c\u03b1\u03b2T\u7ec6\u80de\u7fa4\u5f62\u6210\u7684\u5173\u952e\u6b65\u9aa4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

MHC-\u81ea\u8eab\u80bd\u5728\u80f8\u817a\u4e2d\u7684\u8868\u8fbe<\/p>\n<\/section>\n

\n
\n
\n

\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\uff0c\u672a\u6210\u719f\u7684T\u7ec6\u80de\u4f1a\u9047\u5230\u5404\u79cd\u8868\u8fbeMHC-\u81ea\u8eab\u80bd\u7684\u7ec6\u80de\u7fa4\u3002\u672a\u6210\u719f\u7684T\u7ec6\u80de\u9996\u5148\u4f1a\u9047\u5230\u53c2\u4e0e\u9633\u6027\u9009\u62e9\u7684\u80f8\u817a\u76ae\u8d28\u4e0a\u76ae\u7ec6\u80de\uff0c\u5f53\u5176\u8fc1\u79fb\u5230\u9ad3\u8d28\u65f6\uff0c\u4f1a\u9047\u5230\u53c2\u4e0e\u9634\u6027\u9009\u62e9\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u3001\u4e0a\u76ae\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\uff0c\u6240\u6709\u8fd9\u4e9b\u7ec6\u80de\u7fa4\u90fd\u5728\u4e3b\u52a8\u5411\u672a\u6210\u719f\u7684T\u7ec6\u80de\u9012\u5448\u6297\u539f\u80bd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u6ca1\u6709\u611f\u67d3\u7684\u60c5\u51b5\u4e0b\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u901a\u8fc7\u7b2c10\u7ae0<\/span>\u6240\u8ff0\u7684\u9014\u5f84\u5904\u7406\u548c\u5448\u9012\u81ea\u8eab\u591a\u80bd\u3002\u8fd9\u610f\u5473\u7740\u6b63\u5e38\u7684\u7ec6\u80de\u8d28\u86cb\u767d\u88ab\u86cb\u767d\u9176\u6d88\u5316\uff0c\u5e76\u5411MHC I\u7c7b\u5206\u5b50\u5448\u9012\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u80de\u5916\u86cb\u767d\u5728\u5185\u4f53\u4e2d\u88ab\u6d88\u5316\uff0c\u5411MHC \u2161\u7c7b\u5206\u5b50\u5448\u9012\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u80f8\u817a\u9ad3\u8d28\u4e2d\u7684\u7ec6\u80de\u80fd\u591f\u8868\u8fbe\u901a\u5e38\u5728\u5176\u4ed6\u5668\u5b98\u4e2d\u8868\u8fbe\u7684\u86cb\u767d\u8d28\u3002\u4f8b\u5982\uff0c\u901a\u5e38\u8ba4\u4e3a\u53ea\u6709\u80f0\u5c9b\u03b2\u7ec6\u80de\u80fd\u5206\u6ccc\u80f0\u5c9b\u7d20\uff0c\u80f8\u817a\u9ad3\u7ec6\u80de\u4e5f\u80fd\u5206\u6ccc\uff0c\u8fd9\u4e9b\u80f0\u5c9b\u7d20\u88ab\u52a0\u5de5\u6210\u591a\u80bd\uff0c\u5448\u9012\u5728MHC II\u7c7b\u5206\u5b50\u4e0a\u3002\u81ea\u8eab\u514d\u75ab\u8c03\u8282\u56e0\u5b50AIRE\uff08\u4e00\u79cd\u7279\u6b8a\u7684\u8f6c\u5f55\u56e0\u5b50\uff09\uff0c\u53ef\u4f7f\u80f8\u817a\u9ad3\u8d28\u7ec6\u80de\u8868\u8fbe\u901a\u5e38\u4ec5\u5728\u5176\u4ed6\u5668\u5b98\u4e2d\u8868\u8fbe\u7684\u86cb\u767d\u8d28\u3002AIRE\u57fa\u56e0\u7a81\u53d8\u5c06\u5bfc\u81f4\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u95ee\u9898\uff0c\u5982\u81ea\u8eab\u514d\u75ab\u6027\u591a\u5185\u5206\u6ccc\u817a\u75c5-\u5ff5\u73e0\u83cc\u75c5-\u5916\u80da\u5c42\u8425\u517b\u4e0d\u826f\u7efc\u5408\u5f81(APECED) (Box 15.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u9633\u6027\u9009\u62e9\uff1a\u81ea\u8eab\u9650\u5236\u6027\u7684\u5f62\u6210<\/p>\n<\/section>\n

\n
\n
\n

\u4e3a\u4e86\u80fd\u591f\u7ee7\u7eed\u53d1\u80b2\uff0cDP\u7ec6\u80de\u5fc5\u987b\u5148\u548c\u80f8\u817a\u76ae\u8d28\u4e0a\u76ae\u7ec6\u80de\u4e0a\u7684MHC\u5206\u5b50\u6210\u529f\u7ed3\u5408\u3002\u5927\u591a\u6570DP\u7ec6\u80de\u5728\u80f8\u817a\u76ae\u8d28\u5c42\u51cb\u4ea1\uff0c\u56e0\u4e3a\u5b83\u4eec\u7f3a\u4e4f\u80fd\u591f\u4e0e\u81ea\u8eabMHC\u5206\u5b50\u7ed3\u5408\u7684TCR\u3002\u53ea\u6709\u5177\u6709TCR\uff0c\u5e76\u4e14\u80fd\u4ee5\u9002\u5f53\u4eb2\u548c\u529b\u8bc6\u522b\u81ea\u8eabMHC\u7684DP\u7ec6\u80de\u624d\u80fd\u5b58\u6d3b\u3002\u9633\u6027\u9009\u62e9\u540e\u7684\u7ec6\u80de\u53d7\u5230\u81ea\u8eabMHC\u7684\u9650\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u9634\u6027\u9009\u62e9\uff1a\u81ea\u8eab\u514d\u75ab\u8010\u53d7\u7684\u5f62\u6210<\/p>\n<\/section>\n

\n
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\n

\u7ecf\u8fc7\u9633\u6027\u9009\u62e9\u7684\u7ec6\u80de\u7fa4\u53d7\u81ea\u8eabMHC\u9650\u5236\uff0c\u4f46\u5176\u4e2d\u4e5f\u5305\u62ec\u4e00\u4e9b\u80fd\u8bc6\u522b\u81ea\u8eab\u591a\u80bd\u548cMHC\u7684\u81ea\u8eab\u53cd\u5e94\u6027\u7ec6\u80de\u3002\u8fd9\u4e9b\u81ea\u8eab\u53cd\u5e94\u6027\u7ec6\u80de\u5fc5\u987b\u88ab\u6e05\u9664\uff0c\u5426\u5219\u5bbf\u4e3b\u5c31\u4f1a\u6709\u60a3\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u98ce\u9669\uff0c\u8fd9\u6d89\u53ca\u5230\u9634\u6027\u9009\u62e9\u8fc7\u7a0b\u3002 (Fig. 15.3<\/span>)<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 15.3<\/span> \u53cc\u9633\u6027(DP)\u80f8\u817a\u7ec6\u80de\u4e0e\u80f8\u817a\u6297\u539f\u63d0\u5448\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u53ef\u80fd\u4ea7\u751f\u7684\u4e0d\u540c\u7ed3\u679c\u3002TCR\u8bc6\u522bMHC-\u81ea\u8eab\u80bd\u590d\u5408\u7269\u7684\u4eb2\u548c\u529b\u51b3\u5b9a\u4e86\u8fd9\u4e9b\u7ed3\u679c\u3002DP\uff0c\u53cc\u9633\u6027\uff1bNT reg\uff0c\u81ea\u7136T\u8c03\u8282\u7ec6\u80de\uff1bSP\uff0c\u5355\u9633\u6027\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u5728\u80f8\u817a\u9ad3\u8d28\u53d1\u80b2\u7684DP T\u7ec6\u80de\u66b4\u9732\u5728\u4e00\u7cfb\u5217\u5728\u4f53\u5185\u8868\u8fbe\u7684\u591a\u80bd\u4e4b\u95f4\uff0c\u9634\u6027\u9009\u62e9\u8fc7\u7a0b\u4e2d\uff0c\u4e0e\u81ea\u8eab\u591a\u80bd\u53cd\u5e94\u975e\u5e38\u5f3a\u70c8(\u9ad8\u4eb2\u548c\u529b)\u7684DP\u7ec6\u80de\u88ab\u6dd8\u6c70\uff0c\u4ee5\u6b64\u5f62\u6210\u4e00\u79cd\u81ea\u8eab\u8010\u53d7\u72b6\u6001\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
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\u63a5\u4e0b\u6765\u662fDP\u7ec6\u80de\u80fd\u5426\u8bc6\u522b\u5448\u9012\u5728MHC I\u7c7b\u6216II\u7c7b\u5206\u5b50\u4e0a\u7684\u81ea\u8eab\u6297\u539f\u3002\u8bf7\u8bb0\u4f4f\uff0cCD8\u5206\u5b50\u8bc6\u522bMHC I\u7c7b\uff0c\u800cCD4\u5206\u5b50\u8bc6\u522bMHC II\u7c7b\u3002\u8bc6\u522bMHC\u2160\u7c7b\u5206\u5b50\u4e0a\u7684\u7ec6\u80de\u81ea\u8eab\u6297\u539f\u7684DP\u7ec6\u80de\u505c\u6b62\u8868\u8fbeCD4\uff0c\u8f6c\u5316\u4e3a\u5355\u9633\u6027(SP)CD8+<\/sup>\u7ec6\u80de\u3002\u76f8\u53cd\uff0c\u8bc6\u522bMHC\u2161\u7c7b\u5206\u5b50\u4e0a\u7684\u7ec6\u80de\u81ea\u8eab\u6297\u539f\u7684DP\u7ec6\u80de\u505c\u6b62\u8868\u8fbeCD8\uff0c\u8f6c\u5316\u4e3aCD4+<\/sup>\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728SP\u7684CD4+<\/sup>\u7ec6\u80de\u4e2d\uff0c10%\u5bf9MHC\u2161\u7c7b\u81ea\u8eab\u6297\u539f\u5177\u6709\u6700\u9ad8\u4eb2\u548c\u529b\u7684\u7ec6\u80de\u6fc0\u6d3b\u4e00\u79cd\u540d\u4e3aFOXP3\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u8be5\u8f6c\u5f55\u56e0\u5b50\u4f7f\u8fd9\u4e9b\u7ec6\u80de\u8fdb\u5165\u4e0d\u540c\u7684\u5206\u5316\u9014\u5f84\uff0c\u5e76\u6700\u7ec8\u6210\u719f\u4e3a\u81ea\u7136\u8c03\u8282\u7ec6\u80de(nTregs)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u9634\u6027\u9009\u62e9\u662f\u901a\u8fc7TCR\u4ecb\u5bfc\u7684\u4fe1\u53f7\u8f6c\u5bfc\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002\u51cb\u4ea1\u7684\u7ec6\u80de\u7531\u80f8\u817a\u5de8\u566c\u7ec6\u80de\u541e\u566c\u6e05\u9664\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u636e\u4f30\u8ba1\uff0c\u5728\u76ae\u8d28\u4e2d\u901a\u8fc7\u9633\u6027\u9009\u62e9\u5b58\u6d3b\u4e0b\u6765\u7684\u7ec6\u80de\u4e2d\u6709\u4e09\u5206\u4e4b\u4e8c\u968f\u540e\u5728\u9ad3\u8d28\u4e2d\u7ecf\u8fc7\u9634\u6027\u9009\u62e9\u540e\u51cb\u4ea1\u3002\u56e0\u6b64\uff0c\u53ea\u6709\u5c11\u91cf\u7684\u521d\u59cb\u80f8\u817a\u7ec6\u80de\u53d1\u80b2\u4e3a\u6210\u719f\u7684T\u7ec6\u80de\u8fdb\u5165\u5916\u5468\u8840\u6db2\u548c\u6dcb\u5df4\u7ec4\u7ec7\uff08\u521d\u59cbT\u7ec6\u80de\uff0cantigen-naive, T cells\uff09\u3002\u201cnaive\u201d\u6307\u7684\u662f\u8fd9\u4e9b\u7ec6\u80de\u8fd8\u6ca1\u6709\u9047\u5230\u4e0e\u5b83\u4eec\u7684TCR\u201c\u5339\u914d\u201d\u7684\u5916\u6765\u7684\u3001\u975e\u81ea\u8eab\u7684\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

T\u7ec6\u80de\u53d7\u4f53\u5728\u9633\u6027\u9009\u62e9\u53ca\u9634\u6027\u9009\u62e9\u4e2d\u7684\u4fe1\u53f7\u8f6c\u5bfc<\/p>\n<\/section>\n

\n
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TCR\u4e0eMHC-\u591a\u80bd\u6297\u539f\u590d\u5408\u7269\u7684\u7ed3\u5408\u65e2\u4ecb\u5bfc\u9633\u6027\u9009\u62e9\u53c8\u4ecb\u5bfc\u9634\u6027\u9009\u62e9(\u89c1Fig. 15.3)<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u540c\u6837\u7c7b\u578b\u7684\u53d7\u4f53-\u914d\u4f53\u76f8\u4e92\u4f5c\u7528\u600e\u4e48\u4f1a\u4ea7\u751f\u622a\u7136\u4e0d\u540c\u7684\u7ed3\u679c\uff1f\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0cTCRs\u548cMHC\u80bd\u590d\u5408\u7269\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u4e0d\u540c\u4eb2\u548c\u529b\u4ea7\u751f\u4e0d\u540c\u7684\u7ec6\u80de\u5185\u4fe1\u53f7\u3002\u8fd9\u4e9b\u4fe1\u53f7\u53ef\u80fd\u5728\u6570\u91cf\u4e0a\u6216\u8d28\u91cf\u4e0a\u4e0d\u540c\u3002\u8fd9\u4e9b\u4fe1\u53f7\u7684\u6027\u8d28\u8fd8\u5728\u7814\u7a76\u4e2d\uff0c\u76ee\u524d\u6839\u636e\u73b0\u6709\u6570\u636e\u53ef\u7ed9\u51fa\u7684\u4e00\u4e2a\u7b80\u5355\u89e3\u91ca\u662f\uff0cTCR\u4e0e\u80f8\u817a\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684MHC\u5206\u5b50\u4ee5\u9ad8\u4eb2\u548c\u529b\u7ed3\u5408\u7684\u7ec6\u80de\u53d1\u751f\u51cb\u4ea1\uff0c\u800cTCR\u548cMHC\u5206\u5b50\u4ee5\u8f83\u4f4e\u4eb2\u548c\u529b\uff08\u4f46\u4e5f\u4e0d\u662f\u592a\u4f4e\uff09\u5373\u201c\u4e2d\u7b49\u4eb2\u548c\u529b\u7ed3\u5408\u201d\u7684\u7ec6\u80de\u80fd\u591f\u5b58\u6d3b\u5e76\u7ee7\u7eed\u53d1\u80b2\u6210\u719f\uff0cB\u7ec6\u80de\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u4e5f\u4f1a\u51fa\u73b0\u7c7b\u4f3c\u7684\u73b0\u8c61\u3002\u9aa8\u9ad3\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u8bc6\u522b\u5927\u91cf\u7684\u819c\u81ea\u8eab\u6297\u539f\u7684B\u7ec6\u80de\u4e5f\u4f1a\u5728\u7c7b\u4f3c\u7684\u9634\u6027\u9009\u62e9\u8fc7\u7a0b\u4e2d\u53d1\u751f\u51cb\u4ea1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u5916\u5468\uff1a\u6297\u539f\u5bf9\u521d\u59cbT\u7ec6\u80de\u7684\u6fc0\u6d3b<\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u79bb\u5f00\u80f8\u817a\u7684\u6210\u719fT\u7ec6\u80de\u8fd8\u6ca1\u6709\u9047\u5230\u7279\u5f02\u6027\u6297\u539f\u65f6\u88ab\u79f0\u4e3a\u5e7c\u7a1a\u7684\u6210\u719fT\u7ec6\u80de\uff08\u521d\u59cbT\u7ec6\u80de\uff09\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u9047\u5230\u6297\u539f\u6216\u6b7b\u4ea1\u4e4b\u524d\uff0c\u4f1a\u5728\u8840\u6db2\u4e0e\u4e2d\u592e\u6dcb\u5df4\u5668\u5b98(\u5982\u813e\u3001\u6dcb\u5df4\u7ed3\u3001Peyer\u6591\u5757)\u95f4\u5faa\u73af\u8fbe\u6570\u5e74\u4e4b\u4e45\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 15.4 <\/span>\u6fc0\u6d3b\u521d\u59cbT\u7ec6\u80de<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5916\u5468T\u7ec6\u80de\u8010\u53d7\u6027<\/strong><\/p>\n<\/section>\n

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\u5982\u4e0a\u6240\u8ff0\uff0c\u9634\u6027\u9009\u62e9\u4ea7\u751f\u5177\u6709\u81ea\u6211\u8010\u53d7\u6027\u7684\u6210\u719fT\u7ec6\u80de\u7fa4\u4f53\u3002\u5728\u80f8\u817a\u4e2d\u53d1\u751f\u7684\u9634\u6027\u9009\u62e9\u88ab\u79f0\u4e3a\u4e2d\u67a2\u8010\u53d7\u7684\u8bf1\u5bfc\u3002\u7136\u800c\uff0c\u7531\u4e8e\u4e0d\u662f\u6240\u6709\u7684\u81ea\u8eab\u6297\u539f\u90fd\u80fd\u5728\u80f8\u817a\u4e2d\u9047\u5230\uff0c\u4e00\u4e9b\u81ea\u8eab\u53cd\u5e94\u6027\u7ec6\u80de\u53ef\u80fd\u4f1a\u4ece\u80f8\u817a\u201c\u9003\u9038\u201d\uff0c\u51fa\u73b0\u5728\u80f8\u817a\u4e4b\u5916\u3002\u5728\u5916\u5468\u6709\u51e0\u79cd\u673a\u5236\u53d1\u6325\u4f5c\u7528\uff0c\u4ee5\u786e\u4fdd\u9003\u79bb\u90a3\u91cc\u7684\u6f5c\u5728\u7684\u81ea\u8eab\u53cd\u5e94\u6027T\u7ec6\u80de\u7684\u589e\u6b96\u5f97\u5230\u63a7\u5236\uff0c\u5e76\u4f7f\u5176\u5bf9\u4eba\u4f53\u65e0\u5bb3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f8b\u5982\uff1a<\/p>\n

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2.\u5982\u679c\u4e00\u4e2aT\u7ec6\u80de\u5bf9\u4e00\u79cd\u5e38\u89c1\u7684\u5916\u5468\u6297\u539f\u662f\u7279\u5f02\u7684\uff0c\u9ad8\u6c34\u5e73\u3001\u6301\u7eed\u7684\u6297\u539f\u523a\u6fc0\u5bfc\u81f4T\u7ec6\u80de\u88ab\u53cd\u590d\u6d3b\u5316\uff0c\u90a3\u4e48\u8fd9\u4e2aT\u7ec6\u80de\u5c31\u4f1a\u53d1\u751f\u51cb\u4ea1\u3002\u8fd9\u79cd\u673a\u5236\u88ab\u79f0\u4e3a\u6d3b\u5316\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

3.\u5982\u679c\u523a\u6fc0T\u7ec6\u80de\u53cd\u5e94\u6240\u9700\u7684\u4e00\u4e2a\u6210\u5206\u7f3a\u5931\uff0cT\u7ec6\u80de\u5c31\u4e0d\u4f1a\u5bf9\u6297\u539f\u4ea7\u751f\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u5982\u679c\u76f8\u5173\u7ec4\u7ec7\u4e2d\u6ca1\u6709MHC\u8868\u8fbe\u6216\u7f3a\u5c11\u5171\u523a\u6fc0\u4fe1\u53f7(\u5982CD80\/CD28\uff1b\u89c1Fig15.3<\/span>)\uff0cT\u7ec6\u80de\u5c06\u5904\u4e8e\u529f\u80fd\u4e0d\u6d3b\u8dc3\u72b6\u6001\u3002\u8fd9\u79cd\u673a\u5236\u88ab\u79f0\u4e3a\u201c\u514b\u9686\u5931\u80fd\u201d\u3002<\/p>\n

4.\u5177\u6709\u81ea\u8eab\u6297\u539f\u7279\u5f02\u6027\u7684\u8c03\u8282\u6027T\u7ec6\u80de\u7fa4\u201c\u4fdd\u536b\u201d\u5916\u5468\uff0c\u9632\u6b62\u4efb\u4f55\u81ea\u8eab\u53cd\u5e94\u3002<\/p>\n

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\u6210\u719fT\u7ec6\u80de\u7684\u53cd\u5e94\u548c\u529f\u80fd<\/p>\n<\/section>\n

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\u5e7c\u7a1a\u6210\u719fT\u7ec6\u80de\u9047\u5230\u5176\u540c\u6e90MHC\u6297\u539f\u590d\u5408\u7269\u5e76\u63a5\u6536\u5230\u6765\u81ea\u4e13\u804cAPC\u7684\u5171\u523a\u6fc0\u4fe1\u53f7\u540e\u4f1a\u589e\u6b96\u5e76\u5206\u5316\u4e3a\u6548\u5e94\u7ec6\u80de\uff0c\u7136\u540eCD8+<\/sup>\u548cCD4+<\/sup>T\u7ec6\u80de\u4e9a\u7fa4\u53ef\u4ee5\u4ea7\u751f\u4e0d\u540c\u7684\u6548\u5e94\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7531\u4e8eCD4+<\/sup>\u548cCD8+<\/sup>\u6548\u5e94T\u7ec6\u80de\u7684\u4e0d\u540c\u7279\u5f02\u6027\uff0c\u514d\u75ab\u5e94\u7b54\u53ef\u4ee5\u72ec\u7acb\u5730\u76d1\u6d4b\u7ec6\u80de\u5916\u75c5\u539f\u4f53(\u5982\u7ec6\u83cc)\u548c\u7ec6\u80de\u5185\u75c5\u539f\u4f53(\u5982\u75c5\u6bd2)\u3002CD4+<\/sup>T\u7ec6\u80de\u76d1\u6d4bMHC II\u7c7b\u5206\u5b50\uff0c\u5b83\u63d0\u5448\u5185\u4f53\u4ea7\u751f\u7684\u591a\u80bd(\u4f8b\u5982\uff0c\u6765\u81ea\u541e\u566c\u4f5c\u7528\u7684\u7ec6\u80de\u5916\u75c5\u539f\u4f53)\uff0cCD8+<\/sup>T\u7ec6\u80de\u76d1\u6d4bMHC I\u7c7b\u5206\u5b50\uff0c\u5b83\u63d0\u5448\u7ec6\u80de\u8d28\u4e2d\u4ea7\u751f\u7684\u591a\u80bd(\u4f8b\u5982\u6765\u81ea\u7ec6\u80de\u5185\u75c5\u539f\u4f53-\u5728\u7ec6\u80de\u8d28\u4e2d\u590d\u5236\u7684\u75c5\u6bd2\u7b49)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CD4+<\/sup>T\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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CD4+<\/sup>T\u7ec6\u80de\u8bc6\u522bMHC II\u7c7b\u5206\u5b50\u4e0a\u7684\u6297\u539f\u3002\u6b63\u5982\u5728\u7b2c16\u7ae0<\/span>\u4e2d\u8be6\u7ec6\u8ba8\u8bba\u7684\u90a3\u6837\uff0cCD4+T\u7ec6\u80de\u53ef\u4ee5\u5206\u5316\u4e3a\u4e00\u7cfb\u5217\u4e9a\u7fa4\uff0c\u5305\u62ec\u8f85\u52a9\u6027\u4e9a\u7fa4\uff0c\u5b83\u4eec\u4fc3\u8fdb\u7279\u5b9a\u7c7b\u578b\u7684T\u8f85\u52a9\u7ec6\u80de(TH) (\u901a\u8fc7TH1\u3001TH2\u548cTH17)\u548c\u8c03\u8282\u6027T\u7ec6\u80de\u5e94\u7b54\u3002\u5e7c\u7a1aT\u7ec6\u80de\u5206\u5316\u4e3a\u54ea\u79cd\u7ec6\u80de\u53d6\u51b3\u4e8e\u5b83\u6240\u5904\u7684\u73af\u5883\u4ee5\u53ca\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u7684\u5371\u9669\u4fe1\u53f7\u3002\u4f8b\u5982\uff0c\u5f53\u5b58\u5728\u5371\u9669\u4fe1\u53f7\u65f6\uff0cIL-12\u5bf9\u611f\u67d3\u505a\u51fa\u53cd\u5e94\uff0c\u90a3\u4e48\u4ea7\u751f\u5e94\u7b54\u7684T\u7ec6\u80de\u5f88\u53ef\u80fd\u53d1\u80b2\u6210TH1\u7ec6\u80de\u3002n Tregs\uff08\u81ea\u7136\u8c03\u8282\u6027T\u7ec6\u80de\uff09\u662fTCR\u548cMHC \u2161\u7c7b\u81ea\u8eab\u591a\u80bd\u4e4b\u95f4\u9ad8\u4eb2\u548c\u529b\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c\uff0c\u4f46\u53c8\u4e0d\u8db3\u4ee5\u5f15\u8d77\u9634\u6027\u9009\u62e9\u3002\u7b2c\u4e8c\u79cd\u8c03\u8282\u6027T\u7ec6\u80de\u662f\u9002\u5e94\u6027\u8c03\u8282\u6027T\u7ec6\u80de \uff08iTregs\uff09\u3002\u8fd9\u4e9b\u7ec6\u80de\u662f\u5728\u9002\u5f53\u7684\u73af\u5883\u4e2d\u4ece\u5e7c\u7a1a\u7684CD4+<\/sup>T\u7ec6\u80de\u4e2d\u8bf1\u5bfc\u4ea7\u751f\u7684\u3002\u8c03\u8282\u6027T\u7ec6\u80de\u5c06\u5728\u7b2c18\u7ae0<\/span>\u4e2d\u8be6\u7ec6\u8ba8\u8bba\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CD8+<\/sup>T\u7ec6\u80de\uff1a\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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CD8+<\/sup>T\u7ec6\u80de\u5728\u80f8\u817a\u751f\u6210\u3002\u5b83\u4eec\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u6d3b\u5316\u548c\u5206\u5316\u624d\u80fd\u6210\u4e3a\u6548\u5e94T\u7ec6\u80de\uff0c\u6548\u5e94T\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u88ab\u75c5\u6bd2\u611f\u67d3\u7684\u9776\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de(Box 15.3<\/span>)\u3002CD8+<\/sup>T\u7ec6\u80de\u8bc6\u522bMHC I\u7c7b\u5206\u5b50\u4e0a\u7684\u6297\u539f\u3002MHC I\u7c7b\u5206\u5b50\u51e0\u4e4e\u5b58\u5728\u4e8e\u4eba\u4f53\u6240\u6709\u6709\u6838\u7ec6\u80de\u4e2d\uff0c\u6240\u4ee5CD8+<\/sup>T\u7ec6\u80de\u53ef\u4ee5\u76d1\u6d4b\u6240\u6709\u7ec6\u80de\u7684\u611f\u67d3\u8ff9\u8c61\u3002CD8+<\/sup>T\u7ec6\u80de\u88ab\u6fc0\u6d3b\u6210\u4e3a\u6548\u5e94T\u7ec6\u80de\u7684\u65b9\u5f0f\u6709\u4e24\u79cd\uff0c\u4e00\u79cd\u662f\u9047\u5230\u4e13\u804cAPC\u4e0a\u7684\u6297\u539f\u5e76\u540c\u65f6\u63a5\u53d7\u6765\u81eaMHC-I\u7c7b\u5206\u5b50\uff08\u7b2c\u4e00\u4fe1\u53f7\uff09\u548c\u5171\u523a\u6fc0\u5206\u5b50(\u5982CD80\uff0c\u7b2c\u4e8c\u4fe1\u53f7)\u7684\u6fc0\u6d3b\u4fe1\u53f7\uff0c\u53e6\u4e00\u79cd\u662f\u9047\u5230\u975eAPC\u9776\u7ec6\u80de\u4e0a\u7684\u6297\u539f\u5e76\u4eceCD4+<\/sup>T\u8f85\u52a9\u7ec6\u80de\u91ca\u653e\u7684\u7ec6\u80de\u56e0\u5b50\u90a3\u91cc\u63a5\u6536\u201c\u7b2c\u4e8c\u4fe1\u53f7\u201d\u3002CD8+<\/sup>T\u7ec6\u80de\u901a\u8fc7\u591a\u79cd\u673a\u5236\u6291\u5236\u7ec6\u80de\u5185\u611f\u67d3\uff0c\u8bf1\u5bfc\u611f\u67d3\u7ec6\u80de\u51cb\u4ea1\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u03b3\u03b4T\u7ec6\u80de\u4e9a\u7fa4<\/p>\n<\/section>\n

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\u5982\u672c\u7ae0\u524d\u9762\u6240\u8ff0\uff0c\u8868\u8fbe\u03b3\u03b4TCR\u7684T\u7ec6\u80de\u5360\u6240\u6709T\u7ec6\u80de\u4e2d\u7684\u4e00\u5c0f\u90e8\u5206(<5%)\uff0c\u5e76\u4e14\u4e0e\u03b1\u03b2T\u7ec6\u80de\u662f\u4e0d\u540c\u7684\u8c31\u7cfb\u3002\u03b3\u03b4TCR\u8bc6\u522b\u6297\u539f\u7684\u65b9\u5f0f\u4e0e\u03b1\u03b2TCR\u4e0d\u540c\uff0c\u56e0\u4e3a\u03b3\u03b4TCR\u53ef\u4ee5\u5728\u6ca1\u6709MHC\u2160\u7c7b\u6216\u2161\u7c7b\u5206\u5b50\u7684\u60c5\u51b5\u4e0b\u8bc6\u522b\u5230\u67d0\u4e9b\u672a\u7ecf\u5904\u7406\u7684\u80bd\u548c\u975e\u80bd\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u03b3\u03b4T\u7ec6\u80de\u4f5c\u4e3a\u7b2c\u4e00\u9053\u9632\u7ebf\u7684\u4e00\u90e8\u5206\uff0c\u4e3b\u8981\u8bc6\u522b\u76ae\u80a4\u548c\u80a0\u9053\u7c98\u819c\u4e2d\u7684\u5fae\u751f\u7269\u5165\u4fb5\u8005\u3002\u5b83\u4eec\u80fd\u8bc6\u522b\u5e38\u89c1\u7684\u5fae\u751f\u7269\u75c5\u539f\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5b83\u4eec\u4e0d\u9700\u8981\u52a0\u5de5\u548c\u5448\u9012\u5c31\u80fd\u8bc6\u522b\u4e00\u4e9b\u5e38\u89c1\u7684\u5fae\u751f\u7269\u86cb\u767d\u548c\u975e\u86cb\u767d\u6297\u539f\uff0c\u5982\u7ec6\u83cc\u7ec6\u80de\u58c1\u78f7\u8102\uff0c\u8fd9\u6709\u522b\u4e8e\u03b1\u03b2T\u7ec6\u80de\uff0c\u5e76\u4f7f\u5f97\u5b83\u4eec\u5728\u62b5\u5fa1\u5fae\u751f\u7269\u5165\u4fb5\u7684\u7b2c\u4e00\u9053\u9632\u7ebf\u4e2d\u5177\u6709\u72ec\u7279\u7684\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
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BOX 15.1 \u4e0d\u5b8c\u5168\u6027Di George\u7efc\u5408\u5f81<\/span><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

\u4e00\u4e2a\u5a74\u513f\u88ab\u8bca\u65ad\u51fa\u98df\u9053\u548c\u6c14\u7ba1\u4e4b\u95f4\u6709\u7618\u9053\uff0c\u5e76\u4e14\u7531\u4e8e\u4f4e\u9499\u53d1\u751f\u4e86\u62bd\u6410\u3002\u9762\u90e8\u4e94\u5b98\u53d1\u80b2\u4e0d\u826f\uff0c\u80f8\u90e8X\u7ebf\u7247\u663e\u793a\u80f8\u817a\u7f3a\u5931\uff0c\u8fd9\u4e9b\u662fDi George\u7efc\u5408\u5f81\u7684\u5e38\u89c1\u75c7\u72b6\u3002\u5728\u8be5\u7efc\u5408\u75c7\u4e2d\uff0c\u7b2c\u4e09\u548c\u7b2c\u56db\u54bd\u56ca\u7684\u7ed3\u6784\u53d1\u80b2\u4e0d\u826f<\/span>\uff0c\u5305\u62ec\u63a7\u5236\u8840\u6db2\u9499\u6c34\u5e73\u7684\u80f8\u817a\u548c\u7532\u72b6\u65c1\u817a\u3002\u5e78\u8fd0\u7684\u662f\u8fd9\u540d\u5a74\u513f\u6ca1\u6709\u5fc3\u810f\u7f3a\u9677\uff08\u5fc3\u810f\u7f3a\u9677\u662fDi George \u7efc\u5408\u5f81\u53e6\u4e00\u79cd\u4e3b\u8981\u5f02\u5e38\u75c7\u72b6\uff09\u3002\u8fdb\u4e00\u6b65\u7684\u68c0\u6d4b\u663e\u793a\u5979\u768422\u53f7\u67d3\u8272\u4f53\u6709\u4e00\u90e8\u5206\u7f3a\u5931\uff0c\u8fd9\u4e5f\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u8bca\u65ad\u3002<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

Fig 15.5 <\/span>\u4e00\u4f8b\u60a3\u6709Di George\u7efc\u5408\u5f81\u5973\u5a74\u7684\u6dcb\u5df4\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790\u3002\u5c3d\u7ba1T\u7ec6\u80de\u6570\u91cf\u5f88\u4f4e\uff0c\u8fd9\u4e2a\u5a74\u513f\u8fd8\u662f\u5b58\u6d3b\u4e86\u4e0b\u6765\u3002<\/span><\/p>\n<\/section>\n

\n
\n

\u867d\u7136\u89c2\u5bdf\u5230CD3+<\/sup>T\u7ec6\u80de\u6570\u91cf\u51cf\u5c11\uff0c\u4f46\u8be5\u5a74\u513f\u7684\u53d1\u80b2\u4ecd\u8f83\u6b63\u5e38(Fig. 15.5<\/span>)\u3002\u5979\u7684\u514d\u75ab\u7403\u86cb\u767d\u6c34\u5e73\u662f\u6b63\u5e38\u7684\u3002\u56e0\u6b64\u5f88\u597d\u5730\u62b5\u5fa1\u4e86\u6b63\u5e38\u7684\u513f\u7ae5\u65f6\u671f\u611f\u67d3\uff0c\u6ca1\u6709\u63a5\u53d7\u4efb\u4f55\u7279\u6b8a\u7684\u514d\u75ab\u6cbb\u7597\u3002\u5728\u6210\u5e74\u521d\u671f\uff0c\u5979\u8fc7\u7740\u6b63\u5e38\u7684\u751f\u6d3b\uff08Fig. 15.6<\/span>\uff09\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

Fig 15.6<\/span> Di George\u7efc\u5408\u5f81\u60a3\u8005\u8868\u73b0\u51fa\u8fd9\u79cd\u5fae\u5999\u7684\u201c\u5c0f\u7cbe\u7075\u6837\u201d\u8868\u60c5<\/span><\/p>\n<\/section>\n

\n
\n

\u4e0d\u5b8c\u5168\u6027Di George\u7efc\u5408\u5f81\u7684\u513f\u7ae5\u5728\u6ca1\u6709\u5176\u4ed6\u76f8\u5173\u7684\u75be\u75c5\uff0c\u5982\u5fc3\u810f\u7f3a\u9677\u7684\u60c5\u51b5\u4e0b\u5f80\u5f80\u80fd\u591f\u53d1\u80b2\u6b63\u5e38\uff0c\u5c31\u50cf\u6211\u4eec\u6b63\u5e38\u4eba\u4e00\u6837\u3002\u800c\u5b8c\u5168\u6027Di George\u7efc\u5408\u5f81\u60a3\u8005\u4e0e\u60a3\u6709\u4e25\u91cd\u8054\u5408\u514d\u75ab\u7f3a\u9677\u75be\u75c5\u7684\u60a3\u8005(SCID\uff1b\u7b2c32\u7ae0<\/span>)\u4e00\u6837\uff0c\u5bb9\u6613\u53d1\u751f\u673a\u4f1a\u6027\u611f\u67d3\uff0c\u5982\u771f\u83cc\u548c\u75c5\u6bd2\u611f\u67d3\u7b49\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\n
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\n
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BOX 15.2<\/span>\u81ea\u8eab\u514d\u75ab\u6027\u591a\u5185\u5206\u6ccc\u817a\u75c5-\u5ff5\u73e0\u83cc\u75c5-\u5916\u80da\u5c42\u8425\u517b\u4e0d\u826f\u7efc\u5408\u5f81(APECED)<\/span><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

\u4e00\u540d4\u5c81\u7537\u5b69\u6709\u8179\u6cfb\u3001\u4f53\u91cd\u51cf\u8f7b\u3001\u4f4e\u8840\u538b\u53ca\u5b66\u9f84\u524d\u969c\u788d\u7b49\u75c7\u72b6\u3002\u8bca\u65ad\u51fa\u60a3\u6709\u4e73\u7cdc\u6cfb(\u7b2c28\u7ae0<\/span>)\uff0c\u4f46\u5f00\u59cb\u65e0\u9eb8\u8d28\u996e\u98df\u540e\uff0c\u75c5\u60c5\u6ca1\u6709\u6539\u5584\u3002\u968f\u540e\uff0c\u8bca\u65ad\u80be\u4e0a\u817a\u529f\u80fd\u8870\u7aed\u3001\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u548c\u53e3\u8154\u5ff5\u73e0\u83cc\u611f\u67d3\u3002\u4ed6\u7684\u54e5\u54e5\u4e5f\u6709\u7532\u72b6\u817a\u75be\u75c5\u3002\u8fd9\u4e9b\u7279\u5f81\u63d0\u793a\u4ed6\u53ef\u80fd\u60a3\u6709\u81ea\u8eab\u514d\u75ab\u6027\u591a\u5185\u5206\u6ccc\u817a\u75c5-\u5ff5\u73e0\u83cc\u75c5-\u5916\u80da\u5c42\u8425\u517b\u4e0d\u826f\u7efc\u5408\u5f81\u3002\u968f\u540e\u5bf9\u4ed6\u8fdb\u884c\u4e86\u57fa\u56e0\u68c0\u6d4b\u5e76\u53d1\u73b0AIRE\u57fa\u56e0\u7684\u7eaf\u5408\u5b50\u7a81\u53d8\uff0c\u8fd9\u8bc1\u5b9e\u4e86\u4ed6\u60a3\u6709APECED\u3002\u4e34\u5e8a\u4e0a\uff0c\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u548c\u80be\u4e0a\u817a\u529f\u80fd\u8870\u7aed\u53ef\u7528\u6fc0\u7d20\u66ff\u4ee3\u6cbb\u7597\uff0c\u5ff5\u73e0\u83cc\u611f\u67d3\u4e5f\u5f97\u5230\u4e86\u6cbb\u7597\u3002\u60a3\u6b64\u7c7b\u75be\u75c5\u7684\u75c5\u4eba\u5bb9\u6613\u5728\u5e74\u8f7b\u7684\u65f6\u5019\u5c31\u53d1\u751f\u5168\u79c3\uff08\u5e76\u53d1\u75c7\uff09(Fig. 15.7<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

Fig 15.7<\/span> \u81ea\u8eab\u514d\u75ab\u6027\u591a\u5185\u5206\u6ccc\u817a\u75c5-\u5ff5\u73e0\u83cc\u75c5-\u5916\u80da\u5c42\u53d1\u80b2\u4e0d\u826f\u7efc\u5408\u5f81\u60a3\u8005<\/span><\/p>\n<\/section>\n

\n

APECED\u662f\u7531AIRE\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\uff0c\u80f8\u817a\u7ec6\u80de\u4e0d\u80fd\u8868\u8fbe\u5176\u4ed6\u5668\u5b98\u5982\u7532\u72b6\u817a\u7684\u86cb\u767d\u8d28\u3002\u7531\u4e8e\u8fd9\u4e00\u7f3a\u9677\uff0c\u4f7f\u5f97\u8bc6\u522b\u6765\u81ea\u8fd9\u4e9b\u86cb\u767d\u8d28\u7684\u80bd\u7684\u80f8\u817a\u7ec6\u80de\u6ca1\u6709\u51cb\u4ea1\uff0c\u4f7f\u81ea\u8eab\u53cd\u5e94\u6027T\u7ec6\u80de\u79bb\u5f00\u80f8\u817a\u800c\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/span>\u7b2c16\u7ae0<\/span>\u89e3\u91ca\u4e86\u5ff5\u73e0\u83cc\u611f\u67d3\u7684\u539f\u56e0\u3002<\/span>
<\/p>\n

APECED\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u662f\u81ea\u8eab\u8010\u53d7\u6ca1\u6709\u5f62\u6210\u6240\u9020\u6210\u7684\u4e25\u91cd\u540e\u679c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/span><\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |   \u949f\u96ea\u83b9 \u5f90\u66fc\u65af<\/span><\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u848b\u4fca\u535a<\/span><\/span><\/span><\/section>\n
\u521d\u5ba1 | \u9648\u79cb<\/span>\u8c37<\/span> \u5b8b\u4e50<\/span><\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/section>\n

<\/section>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
<\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n


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\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u4e3a\u4e86\u4fdd\u62a4\u5bbf\u4e3b\u514d\u53d7\u611f\u67d3\uff0cT\u7ec6\u80de\u5fc5\u987b\u5305\u542b\u9488\u5bf9\u5404\u79cd\u5404\u6837\u6297\u539f\u7684TCR\uff08T cell receptor\uff09\u7684\u4e9a\u7fa4\u3002\u6bcf\u4e2a\u5355\u72ec\u7684T\u7ec6\u80de\u90fd\u8868\u8fbe\u4e00\u79cd\u72ec\u7279\u7684\u53d7\u4f53\uff0c\u8fd9\u79cd\u53d7\u4f53\u80fd\u591f\u8bc6\u522b\u7531\u81ea\u8eab\u4e3b\u8981\u7ec4\u7ec7\u76f8…<\/p>\n","protected":false},"author":1,"featured_media":3529,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[58],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3538"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3538"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3538\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3529"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3538"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}