{"id":3572,"date":"2021-07-26T23:10:48","date_gmt":"2021-07-26T15:10:48","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2021\/07\/26\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac18%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e8%b0%83%e8%8a%82\/"},"modified":"2021-07-26T23:10:48","modified_gmt":"2021-07-26T15:10:48","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac18%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e8%b0%83%e8%8a%82","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2021\/07\/26\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac18%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e8%b0%83%e8%8a%82\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282"},"content":{"rendered":"
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\u5bfc \u8bfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7cfb\u7edf\u4e0d\u4ec5\u80fd\u591f\u9884\u9632\u548c\u62b5\u5fa1\u4e25\u91cd\u611f\u67d3\u3002\u5982\u7b2c35\u7ae0<\/span>\u6240\u8ff0\uff0c\u5b83\u8fd8\u53ef\u4ee5\u5bf9\u6297\u80bf\u7624\u3002\u4e3a\u5b9e\u73b0\u8fd9\u4e9b\u76ee\u6807\uff0c\u514d\u75ab\u7cfb\u7edf\u5f62\u6210\u4e86\u5f3a\u6709\u529b\u7684\u6548\u5e94\u673a\u5236\u3002\u56e0\u6b64\u514d\u75ab\u7cfb\u7edf\u5931\u63a7\u4f1a\u9020\u6210\u76f8\u5f53\u5927\u7684\u635f\u5bb3\uff0c\u800c\u81ea\u8eab\u7684\u514d\u75ab\u5e94\u7b54\u5931\u63a7\u4e5f\u4f1a\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u4f8b\u5982\uff0cI\u578b\u7cd6\u5c3f\u75c5\u548c\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff0c\u90fd\u4f1a\u51fa\u73b0\u4e25\u91cd\u75c7\u72b6\u751a\u81f3\u5a01\u80c1\u751f\u547d\u3002\u6b64\u5916\uff0c\u5bf9\u4e00\u4e9b\u65e0\u5bb3\u73af\u5883\u7269\u8d28\u7684\u514d\u75ab\u53cd\u5e94\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8fc7\u654f\u3002\u5728\u7f8e\u56fd\uff0c\u6700\u4e25\u91cd\u7684\u8fc7\u654f\u53cd\u5e94\u6bcf\u5e74\u90fd\u4f1a\u5bfc\u81f4\u6570\u767e\u4eba\u6b7b\u4ea1\u3002\u8fd9\u4e9b\u4f8b\u5b50\u8bf4\u660e\u4e86\u5f53\u514d\u75ab\u53cd\u5e94\u4e0d\u53d7\u8c03\u63a7\u65f6\u4f1a\u51fa\u73b0\u4e25\u91cd\u7684\u540e\u679c\u3002\u672c\u7ae0\u7684\u5176\u4f59\u90e8\u5206\u5219\u63cf\u8ff0\u4e86\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7cfb\u7edf\u5bf9\u81ea\u8eab\u6297\u539f\u548c\u65e0\u5bb3\u7684\u73af\u5883\u6297\u539f\u5177\u6709\u8010\u53d7\u6027\u3002\u8010\u53d7\u6027\u53ef\u4ee5\u88ab\u5b9a\u4e49\u4e3a\u201c\u514d\u75ab\u7cfb\u7edf\u5bf9\u5176\u80fd\u591f\u8bc6\u522b\u548c\u653b\u51fb\u7684\u5206\u5b50\u5904\u4e8e\u65e0\u53cd\u5e94\u72b6\u6001\u201d\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u867d\u7136\u8868\u8fbe\u81ea\u8eab\u6216\u65e0\u5bb3\u73af\u5883\u6297\u539f\u53d7\u4f53\u7684\u7ec6\u80de\u5728\u53d7\u4f53\u57fa\u56e0\u91cd\u6392\u8fc7\u7a0b\u4e2d\u4ea7\u751f\uff0c\u4f46\u8fd9\u4e9b\u7ec6\u80de\u4f1a\u88ab\u6740\u6b7b\u6216\u65e0\u6cd5\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6211\u4eec\u673a\u4f53\u5185\u6d89\u53ca\u591a\u4e2a\u201c\u68c0\u67e5\u7ad9\u201d\uff0c\u4ee5\u9632\u6b62\u81ea\u8eab\u514d\u75ab\u6216\u8fc7\u654f\u7684\u7834\u574f\u6027\u5f71\u54cd\u3002\u5982\u4e0a\u56fe\uff1a<\/p>\n

\u2460\u5bf9\u81ea\u8eab\u6297\u539f\u7684\u8010\u53d7\u662f\u901a\u8fc7\u80f8\u817a\u548c\u9aa8\u9ad3\u7684\u4e2d\u67a2\u8010\u53d7\u548c\u6240\u6709\u5176\u4ed6\u7ec4\u7ec7\u7684\u5916\u5468\u8010\u53d7\u6765\u5b9e\u73b0\u7684\u3002\u5916\u5468\u8010\u53d7\u6d89\u53ca\u591a\u79cd\u4e0d\u540c\u7684\u673a\u5236\uff0c\u7b2c15\u7ae0<\/span>\u4ecb\u7ecd\u4e86\u5176\u4e2d\u4e00\u4e9b\u673a\u5236\u3002<\/p>\n

\u2461\u65e0\u5bb3\u7684\u73af\u5883\u6297\u539f\u5728\u80f8\u817a\u6216\u9aa8\u9ad3\uff08\u4e2d\u67a2\u514d\u75ab\u5668\u5b98\uff09\u4e2d\u4e0d\u8868\u8fbe\uff0c\u56e0\u6b64\u5bf9\u8fd9\u4e9b\u6297\u539f\u7684\u8010\u53d7\u662f\u901a\u8fc7\u5916\u5468\u673a\u5236\u5b9e\u73b0\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u8010\u53d7\u673a\u5236\u7565\u6709\u4e0d\u540c\u3002\u8010\u53d7\u673a\u5236\u5728Table 18.1<\/span>\u4e2d\u8fdb\u884c\u4e86\u603b\u7ed3\u3002\u53d1\u751f\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5982\u7cd6\u5c3f\u75c5\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u8fc7\u654f\u662f\u5f88\u5e38\u89c1\u7684\uff0c\u8fd9\u8868\u660e\u4e2d\u67a2\u548c\u5916\u5468\u8010\u53d7\u673a\u5236\u5931\u5e38\u7684\u9891\u7387\u76f8\u5f53\u9ad8\u3002\u4e86\u89e3\u8fd9\u4e9b\u673a\u5236\u6709\u52a9\u4e8e\u4e86\u89e3\u8fd9\u4e9b\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u672c\u7ae0\u56de\u987e\u5e76\u8ba8\u8bba\u4e86\u4e2d\u67a2\u8010\u53d7\u4ee5\u53ca\u5916\u5468\u8010\u53d7\u7684\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table18.1<\/span> B\u7ec6\u80de\u548cT\u7ec6\u80deT\u7ec6\u80de\u8010\u53d7\u7684\u4e3b\u8981\u7279\u5f81<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e2d\u67a2\u8010\u53d7<\/p>\n<\/section>\n

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\u9aa8\u9ad3\u4e2d\u8bc6\u522b\u81ea\u8eab\u6297\u539f\u7684\u672a\u6210\u719fB\u7ec6\u80de\u7ecf\u5386\u9634\u6027\u9009\u62e9\u540e\u53d1\u751f\u51cb\u4ea1\u3002\u800c\u5bf9\u4e8e\u80f8\u817a\u4e2dT\u7ec6\u80de\u6765\u8bf4\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u66f4\u4e3a\u590d\u6742\u3002<\/p>\n

\u2460\u4e0d\u8bc6\u522b\u81ea\u8eabMHC\u7684\u80f8\u817a\u7ec6\u80de\u4e0d\u80fd\u6210\u529f\u5730\u88ab\u9633\u6027\u9009\u62e9\u800c\u51cb\u4ea1\u3002\uff08\u5373\u53ea\u6709\u8bc6\u522bMHC\u7684\u80f8\u817a\u7ec6\u80de\u624d\u5b58\u6d3b\uff09<\/p>\n

\u2461\u5927\u591a\u6570\u4ee5\u9ad8\u4eb2\u548c\u529b\u8bc6\u522b\u81ea\u8eab\u591a\u80bd\u548c\u81ea\u8eabMHC\u7684\u80f8\u817a\u7ec6\u80de\u4e5f\u4f1a\u6b7b\u4e8e\u51cb\u4ea1(\u9634\u6027\u9009\u62e9)\u3002<\/p>\n

\u2462\u4e00\u4e9b\u8bc6\u522b\u81ea\u8eab\u80bd\u548c\u81ea\u8eabMHC\u7684CD4+\u80f8\u817a\u7ec6\u80de\u6210\u4e3aT\u8c03\u8282\u7ec6\u80de(Tregs)(Fig. 15.3<\/span>)\u3002<\/p>\n

\u901a\u8fc7\u8fd9\u4e9b\u673a\u5236\uff0c95%\u523099%\u7684\u80f8\u817a\u7ec6\u80de\u5728\u80f8\u817a\u7684\u9009\u62e9\u8fc7\u7a0b\u4e2d\u6b7b\u4ea1\u3002\u79bb\u5f00\u80f8\u817a\u7684\u7ec6\u80de\u4e0d\u80fd\u4ee5\u9ad8\u4eb2\u548c\u529b\u8bc6\u522b\u81ea\u8eab\u591a\u80bd\u548c\u81ea\u8eabMHC\uff0c\u9664\u975e\u662f\u8c03\u8282\u6027T\u7ec6\u80de\u3002<\/p>\n

\u79bb\u5f00\u80f8\u817a\u7684\u5e7c\u7a1aT\u7ec6\u80de\u53d7\u5230\u7b2c\u4e8c\u4e2a\u68c0\u67e5\u70b9\u7684\u5f71\u54cd\uff1a\u5916\u5468\u8010\u53d7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5916\u5468\u8010\u53d7<\/p>\n<\/section>\n

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\u514d\u75ab\u7279\u6743\u90e8\u4f4d<\/p>\n<\/section>\n

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\u514d\u75ab\u7279\u6743\u90e8\u4f4d\u662f\u6307\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u514d\u75ab\u7ec6\u80de\u672a\u63a5\u89e6\u8fc7\u90e8\u4f4d\u3002\u2460T\u7ec6\u80de\u4e0d\u4f1a\u5728\u514d\u75ab\u7279\u6743\u7ec4\u7ec7\u4e2d\u5faa\u73af\u3002\u2461\u514d\u75ab\u7403\u86cb\u767d(Ig)\u4e5f\u53ef\u80fd\u4e0d\u80fd\u5728\u663e\u8457\u6c34\u5e73\u4e0a\u6269\u6563\u5230\u8fd9\u4e9b\u7ec4\u7ec7\u4e2d\u3002\u2462\u514d\u75ab\u7279\u6743\u7ec4\u7ec7\u5305\u62ec\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3001\u773c\u775b\u548c\u751f\u6b96\u5668\u5b98\u7b49\u5bf9\u514d\u75ab\u7cfb\u7edf\u6709\u4e00\u5b9a\u7269\u7406\u969c\u788d\u7684\u5668\u5b98\u7ec4\u7ec7\u3002\u4f8b\u5982\uff0cIg\u5206\u5b50\u5f88\u96be\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u6269\u6563\uff0c\u56e0\u6b64\u8111\u810a\u6db2(CSF)\u4e2d\u7684IgG\u6c34\u5e73\u4e0d\u5230\u8840\u6db2\u4e2d\u7684\u767e\u5206\u4e4b\u4e00\u3002\u2463\u5171\u523a\u6fc0\u5206\u5b50\u7684\u6c34\u5e73\u5f88\u4f4e\uff0cT\u7ec6\u80de\u4e0d\u80fd\u88ab\u6fc0\u6d3b\u3002\u2464\u6700\u540e\uff0cFas\u914d\u4f53(FasL)\u5728\u67d0\u4e9b\u514d\u75ab\u4f18\u52bf\u90e8\u4f4d\u8868\u8fbe\uff0cFasL\u8bf1\u5bfc\u8fdb\u5165\u8fd9\u4e9b\u7ec4\u7ec7\u7684T\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7279\u514d\u6743\u53ea\u5728\u52a8\u6001\u5e73\u8861\u4e2d\u8d77\u4f5c\u7528\u3002\u5982\u679c\u8fd9\u4e9b\u5668\u5b98\u4e2d\u7684\u4efb\u4f55\u4e00\u4e2a\u56e0\u521b\u4f24\u800c\u53d7\u635f\uff0c\u6216\u8005\u56e0\u611f\u67d3\u5f15\u53d1\u708e\u75c7\uff0c\u8be5\u5668\u5b98\u7684\u5de8\u566c\u7ec6\u80de\u4f1a\u5c06\u6297\u539f\u4ece\u7ec4\u7ec7\u8fd0\u9001\u5230\u6240\u5c5e\u7684\u6dcb\u5df4\u7ed3\uff0c\u4ece\u800c\u5f15\u53d1\u6f5c\u5728\u7684\u514d\u75ab\u53cd\u5e94\u3002\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u5f15\u53d1\u7684\u708e\u75c7\u4f1a\u5f71\u54cd\u7ec6\u80de\u9ecf\u9644\u5206\u5b50(CAM)\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4f7fT\u7ec6\u80de\u5f00\u59cb\u5728\u8fd9\u4e9b\u7ec4\u7ec7\u4e2d\u5faa\u73af\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80ce\u76d8\u548c\u80ce\u513f\u662f\u4e00\u79cd\u7279\u6b8a\u7c7b\u578b\u7684\u514d\u75ab\u7279\u6743\u7ec4\u7ec7\u3002\u5982\u679cT\u7ec6\u80de\u8fdb\u5165\u80ce\u76d8\uff0c\u5c31\u4f1a\u88ab\u963b\u6b62\u53d1\u6325\u4f5c\u7528\uff0c\u800cIgG\u5219\u901a\u8fc7\u80ce\u76d8\u4fdd\u62a4\u53d1\u80b2\u4e2d\u7684\u80ce\u513f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7b2c16\u7ae0\u4e2d\u8bb2\u89e3\u5230<\/span><\/span>\uff0cT\u7ec6\u80de\u9700\u8981\u534f\u540c\u523a\u6fc0\u624d\u80fd\u88ab\u6fc0\u6d3b\u3002\u5171\u523a\u6fc0\u4f5c\u7528\u901a\u5e38\u7531APC\u6216\u9644\u8fd1\u5bf9\u611f\u67d3\u6709\u53cd\u5e94\u7684\u5176\u4ed6\u7ec6\u80de\u63d0\u4f9b\u3002\u5982\u679cT\u7ec6\u80de\u5728\u6ca1\u6709\u5171\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\u8bc6\u522bMHC\u5206\u5b50\u4e0a\u7684\u6297\u539f\uff0cT\u7ec6\u80de\u5c06\u4e0d\u4f1a\u6709\u53cd\u5e94\uff0c\u5e76\u5c06\u8fdb\u5165\u4e00\u79cd\u88ab\u79f0\u4e3a\u65e0\u80fd\u7684\u4f11\u7720\u72b6\u6001(Fig. 18.1A<\/span>)\u3002
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\u4f11\u7720\u7684T\u7ec6\u80de\u5e76\u6ca1\u6709\u6b7b\u4ea1\u5e76\u4e14\u53ef\u4ee5\u5b58\u6d3b\u4e00\u6bb5\u65f6\u95f4\u3002\u5982\u679c\u5728\u672a\u6765\u7684\u67d0\u4e2a\u65f6\u5019\u63d0\u4f9b\u5171\u523a\u6fc0\u56e0\u5b50\uff0c\u53ef\u4ee5\u9006\u8f6c\u5176\u4f11\u7720\u72b6\u6001\u800c\u88ab\u6fc0\u6d3b\u3002\u8fd9\u4e2a\u673a\u5236\u5bf9\u75ab\u82d7\u7684\u53d1\u5c55\u6709\u91cd\u8981\u610f\u4e49\uff0c\u91cd\u7ec4\u86cb\u767d\u75ab\u82d7\u6548\u679c\u4e0d\u662f\u5f88\u597d\uff0c\u867d\u7136\u86cb\u767d\u8d28\u662f\u7531APC\u5904\u7406\u5e76\u88abCD4+T\u7ec6\u80de\u8bc6\u522b\uff0c\u4f46\u7531\u4e8e\u7f3a\u4e4f\u534f\u540c\u523a\u6fc0\u4f5c\u7528\uff0c\u4e0d\u4f1a\u53d1\u751f\u514d\u75ab\u53cd\u5e94\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e00\u70b9\uff0c\u75ab\u82d7\u4e2d\u52a0\u5165\u4e86\u4e00\u79cd\u4f50\u5242\u3002\u4f50\u5242\u662f\u4e00\u79cd\u80fd\u591f\u523a\u6fc0\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4ece\u800c\u63d0\u4f9b\u534f\u540c\u523a\u6fc0\u7684\u7269\u8d28\u4ece\u800c\u63d0\u9ad8\u75ab\u82d7\u7684\u201c\u514d\u75ab\u539f\u6027\u201d\u3002\u8bb8\u591a\u75ab\u82d7\u4f7f\u7528\u975e\u5e38\u6e29\u548c\u7684\u4f50\u5242\uff0c\u4f8b\u5982\uff0c\u6c22\u6c27\u5316\u94dd(\u660e\u77fe)\u7528\u4e8e\u4e59\u809d\u75ab\u82d7\u3002\u5728\u672a\u6765\uff0c\u5c06\u5f00\u53d1\u66f4\u6709\u6548\u7684\u4f50\u5242\u6765\u5236\u9020\u66f4\u591a\u7684\u5177\u6709\u514d\u75ab\u539f\u6027\u7684\u75ab\u82d7(\u7b2c25\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0d\u4f9d\u8d56T\u7ec6\u80de\u8f85\u52a9\u7684B\u7ec6\u80de\u53ef\u4ee5\u5728\u6ca1\u6709T\u7ec6\u80de\u5e2e\u52a9\u7684\u60c5\u51b5\u4e0b\u5bf9\u591a\u7cd6\u4ea7\u751f\u53cd\u5e94(\u7b2c14\u7ae0<\/span>)\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u5bf9\u86cb\u767d\u8d28\u6297\u539f\u6709\u53cd\u5e94\u7684B\u7ec6\u80de\u5982\u679c\u6ca1\u6709\u63a5\u53d7T\u7ec6\u80de\u7684\u5e2e\u52a9\uff0c\u529f\u80fd\u5c31\u4f1a\u4e27\u5931(Fig. 18.1B<\/span>)\u3002\u56e0\u6b64\uff0c\u5982\u679cT\u8f85\u52a9\u7ec6\u80de\u56e0\u4e3a\u8010\u53d7\u673a\u5236\u800c\u4e0d\u518d\u80fd\u591f\u63d0\u4f9b\u5e2e\u52a9\uff0c\u90a3\u4e48\u53c2\u4e0e\u4efb\u4f55\u540c\u4e00\u514d\u75ab\u53cd\u5e94\u7684B\u7ec6\u80de\u4e5f\u5c06\u65e0\u6cd5\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6d3b\u5316\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1<\/p>\n<\/section>\n

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\u6d3b\u5316\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1(AICD)\u53d1\u751f\u5728\u53cd\u590d\u66b4\u9732\u4e8e\u540c\u4e00\u6297\u539f\u7684T\u7ec6\u80de\u4e2d\u3002\u8fd9\u4e9bT\u7ec6\u80de\u4f1a\u540c\u65f6\u8868\u8fbeFas\u548cFasL\uff0c\u4e4b\u540e\u8981\u4e48\u81ea\u6740\uff0c\u8981\u4e48\u88ab\u90bb\u8fd1\u7ec6\u80de\u6740\u6b7b\u3002\u8fd9\u4e9bT\u7ec6\u80de\u5c06\u6c38\u8fdc\u4eceT\u7ec6\u80de\u8c31\u7cfb\u4e2d\u6d88\u5931(Fig.18.2<\/span>)\u3002\u6700\u7ec8\uff0c\u5e94\u7b54T\u7ec6\u80de\u7684\u514b\u9686\u88ab\u6c38\u4e45\u6e05\u9664\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig18.1<\/span>T\u7ec6\u80de(A)\u548cB\u7ec6\u80de(B)\u7684\u7f3a\u4e4f\u5206\u522b\u4f1a\u5bfc\u81f4\u7ec6\u80de\u56e0\u7f3a\u4e4f\u5171\u523a\u6fc0\u6216T\u7ec6\u80de\u5e2e\u52a9\u800c\u4e27\u5931\u529f\u80fd<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8c03\u8282\u6027T\u7ec6\u80de<\/p>\n<\/section>\n

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\u8c03\u8282\u6027T\u7ec6\u80de\u4ee5\u6297\u539f\u7279\u5f02\u6027\u7684\u65b9\u5f0f\u65bd\u52a0\u5916\u5468\u8010\u53d7\u3002\u548c\u5176\u4ed6CD4+T\u7ec6\u80de\u4e00\u6837\uff0c\u5b83\u4eec\u4e5f\u6709\u9488\u5bf9MHC II\u7c7b\u548c\u6297\u539f\u80bd\u7684\u6297\u539f\u53d7\u4f53\u3002\u8c03\u8282\u6027T\u7ec6\u80de\u5bf9\u81ea\u8eab\u6297\u539f\u548c\u65e0\u5bb3\u7684\u73af\u5883\u6297\u539f\u90fd\u6709\u7279\u5f02\u6027\uff0c\u56e0\u6b64\u5728\u9884\u9632\u81ea\u8eab\u514d\u75ab\u548c\u8fc7\u654f\u53cd\u5e94\u65b9\u9762\u6709\u4e00\u5b9a\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Figure 18.3<\/span>\u663e\u793a\u4e86\u4e24\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u8c03\u8282\u6027T\u7ec6\u80de\u3002T\u7ec6\u80de\u5728\u80f8\u817a\u6210\u719f\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u81ea\u7136\u8c03\u8282T\u7ec6\u80de(nTregs)\u3002\u80f8\u817a\u7ec6\u80de\u4ee5\u9ad8\u4eb2\u548c\u529b\u8bc6\u522b\u81ea\u8eab\u6297\u539f\u548cMHCII\u7c7b\u5206\u5b50(Fig.15.3<\/span>)\uff0c\u4e3b\u8981\u7684\u8f6c\u5f55\u56e0\u5b50FOXP3\u88ab\u6fc0\u6d3b\uff0c\u5f15\u5bfc\u7ec6\u80de\u671d\u7740\u8c03\u8282\u6027T\u7ec6\u80de\u5206\u5316\u3002\u867d\u7136\u81ea\u7136\u8c03\u8282T\u7ec6\u80de\u5728\u80f8\u817a\u53d1\u80b2\uff0c\u4f46\u5b83\u4eec\u4e5f\u53c2\u4e0e\u5916\u5468\u7684\u8010\u53d7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bf1\u5bfc\u6027\u8c03\u8282T\u7ec6\u80de\u662f\u5728\u7279\u5b9a\u6761\u4ef6\u4e0b\u7531\u5916\u5468\u539f\u59cbT\u7ec6\u80de\u5206\u5316\u800c\u6765\u7684\u4e00\u79cd\u8c03\u8282\u6027T\u7ec6\u80de\u3002\u4f8b\u5982\uff0c\u5728\u80c3\u80a0\u9053\u4e2d\uff0c\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2(TGF-\u03b2)\u7531\u4e0a\u76ae\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u5206\u6ccc\u3002\u5982\u679c\u80a0\u7cfb\u819c\u6dcb\u5df4\u7ed3\u4e2d\u7684\u5e7c\u7a1aT\u7ec6\u80de\u5728\u6297\u539f\u523a\u6fc0\u8fc7\u7a0b\u4e2d\u66b4\u9732\u4e8e\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\uff0c\u5b83\u53ef\u80fd\u4f1a\u6210\u719f\u4e3a\u8bf1\u5bfc\u6027\u8c03\u8282T\u7ec6\u80de\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u88ab\u79f0\u4e3a\u8010\u53d7(\u89c1Box18.2<\/span>)\u3002\u8fd9\u6837\u5728\u8fdb\u5316\u4e0a\u7684\u597d\u5904\u662f\uff0c\u4ece\u98df\u7269\u6216\u65e0\u5bb3\u80a0\u9053\u7ec6\u83cc\u4e2d\u63d0\u53d6\u7684\u591a\u80bd\u4e0d\u4f1a\u5f15\u53d1\u514d\u75ab\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u5f53\u6297\u539f\u91cd\u590d\u66b4\u9732\u65f6\uff0c\u5b83\u4e5f\u53ef\u4ee5\u88ab\u8bf1\u5bfc\u3002\u5728\u5176\u4ed6\u60c5\u51b5\u4e0b\uff0c\u514d\u75ab\u6291\u5236\u836f\u7269\u4f1a\u201c\u8feb\u4f7f\u201d\u7b2c\u4e00\u6b21\u8bc6\u522b\u6297\u539f\u7684\u5e7c\u7a1aT\u7ec6\u80de\u6210\u4e3a\u5b83\u7684\u8c03\u8282\u8005\u3002\u8fd9\u5728\u79fb\u690d\u4e2d\u6709\u76f8\u5f53\u5927\u7684\u597d\u5904\uff0c\u5bf9\u5176\u4ed6\u533b\u5b66\u5206\u652f\u4e5f\u6709\u5f71\u54cd\uff0c\u5728\u8fd9\u4e9b\u5206\u652f\u4e2d\uff0c\u6291\u5236\u514d\u75ab\u53cd\u5e94\u662f\u53ef\u53d6\u7684\uff0c\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u5bf9\u8bf1\u5bfc\u6027\u8c03\u8282T\u7ec6\u80de\u7684\u7814\u7a76\u53d1\u5c55\u8fc5\u901f\u3002\u5c3d\u7ba1\u8fd9\u91cc\u6ca1\u6709\u8be6\u7ec6\u63cf\u8ff0\u5b83\u4eec\uff0c\u4f46\u4f60\u53ef\u4ee5\u5728\u5176\u4ed6\u5730\u65b9\u8bfb\u5230\u5173\u4e8eTh3\u548cTr1 \u7ec6\u80de\u7684\u4fe1\u606f\uff0c\u5b83\u4eec\u5f88\u53ef\u80fd\u662f\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u5b50\u96c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 18.2<\/span> \u6fc0\u6d3b\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1(AICD)\u9a71\u52a8T\u7ec6\u80de\u4f7f\u7528Fas\u548cFas\u914d\u4f53(FasL)\u6740\u6b7b\u81ea\u5df1\u6216\u5f7c\u6b64<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 18.3<\/span> \u5de6\u56fe\uff0c\u80f8\u817a\u4ea7\u751f\u81ea\u7136T\u8c03\u8282\u7ec6\u80de(nTreg)\uff0c\u80a0\u7cfb\u819c\u6dcb\u5df4\u7ed3\u4ea7\u751f\u8bf1\u5bfc\u6027T\u8c03\u8282\u7ec6\u80de(iTreg)\u3002\u4e00\u4e2aT reg\u901a\u8fc7\u5206\u6ccc\u767d\u7ec6\u80de\u4ecb\u7d2010(IL-10)\u6765\u6291\u5236\u90bb\u8fd1\u7684T\u8f85\u52a9\u7ec6\u80de(TH)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5f53\u8c03\u8282\u6027T\u7ec6\u80de\u8bc6\u522b\u6297\u539f\u65f6\uff0c\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u767d\u7ec6\u80de\u4ecb\u7d2010(IL-10)\u6216\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\u6765\u6291\u5236\u90bb\u8fd1\u7684T\u7ec6\u80de\u3002\u53ef\u80fd\u8fd8\u6d89\u53ca\u5176\u4ed6\u673a\u5236\uff0c\u4f8b\u5982\uff0c\u8c03\u8282\u6027T\u7ec6\u80de\u4e5f\u80fd\u591f\u901a\u8fc7\u76f4\u63a5\u63a5\u89e6\u6765\u6291\u5236T\u7ec6\u80de\u3002Treg\u9644\u8fd1\u6297\u539f\u7684T\u7ec6\u80de\u5c06\u65e0\u6cd5\u505a\u51fa\u5e94\u7b54<\/span>\u3002\u56e0\u6b64\uff0c\u8c03\u8282\u6027T\u7ec6\u80de\u662f\u4e00\u79cd\u786e\u4fdd\u6297\u539f\u8010\u53d7\u6027\u7684\u6709\u6548\u624b\u6bb5\uff0c\u56e0\u4e3a\u4e00\u4e2a\u8c03\u8282\u6027T\u7ec6\u80de\u80fd\u591f\u6291\u5236\u8bb8\u591a\u90bb\u8fd1\u7684T\u7ec6\u80de\u5bf9\u6297\u539f\u505a\u51fa\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u672c\u7ae0\u4e2d\uff0c\u4e86\u89e3\u4f50\u5242\u5982\u4f55\u5e2e\u52a9\u5236\u9020\u6709\u6548\u75ab\u82d7\u3002Boxes 18.1<\/span>\u548c18.2<\/span>\u63cf\u8ff0\u4e86\u8010\u53d7\u6027\u7684\u66f4\u591a\u4e34\u5e8a\u542b\u4e49\u3002Table 18.2<\/span>\u663e\u793a\u4e86\u6709\u5229\u4e8e\u514d\u75ab\u53cd\u5e94\u6216\u8010\u53d7\u7684\u56e0\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Table 18.2<\/span> \u6709\u5229\u4e8e\u514d\u75abT\u8010\u53d7\u6216\u514d\u75ab\u5e94\u7b54\u7684\u56e0\u7d20<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 18.1<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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5\u5e74\u524d\uff0c\u4e00\u4f4d\u7537\u5b50\u628a\u517b\u8702\u4f5c\u4e3a\u7231\u597d\uff0c\u5728\u82b1\u56ed\u540e\u9762\u517b\u4e86\u4e24\u4e2a\u8702\u7bb1(Fig18.4<\/span>)\u3002\u6709\u65f6\u4ed6\u5fd8\u4e86\u7a7f\u8702\u670d\uff0c\u6bcf\u5e74\u590f\u5929\u4ed6\u90fd\u4f1a\u88ab\u871c\u8702\u8707\u8fd120\u6b21\u3002\u5c3d\u7ba1\u523a\u75db\u662f\u75db\u82e6\u7684\uff0c\u4f46\u4ed6\u5e76\u6ca1\u6709\u91c7\u53d6\u5e72\u9884\u3002\u53bb\u5e74\u590f\u5929\uff0c\u4ed6\u7684\u59bb\u5b50\u5728\u88ab\u871c\u8702\u8707\u540e\u76845\u5206\u949f\u5185\u51fa\u73b0\u5e7f\u6cdb\u76ae\u75b9\u3002\u4eca\u5e74\u518d\u6b21\u88ab\u8707\uff0c\u5267\u70c8\u5934\u6655\uff0c5\u5206\u949f\u540e\u5931\u53bb\u4e86\u77e5\u89c9\u3002\u4e13\u79d1\u533b\u751f\u8bc1\u5b9e\u5979\u5bf9\u8702\u6bd2\u8fc7\u654f(\u7b2c27\u7ae0<\/span>)\u3002\u4e3a\u4ec0\u4e48\u4e00\u4e2a\u4eba\u53ef\u4ee5\u5fcd\u53d7\u9891\u7e41\u7684\u53ee\u54ac\uff0c\u800c\u53e6\u4e00\u4e2a\u4eba\u5374\u4e0d\u80fd\u5fcd\u53d7\u53ee\u54ac\u800c\u5bfc\u81f4\u8fc7\u654f\u53cd\u5e94\uff1f<\/p>\n

\u8702\u6bd2\u8fc7\u654f\u6700\u6709\u53ef\u80fd\u53d1\u751f\u5728\u5f88\u5c11\u88ab\u871c\u8702\u53ee\u54ac\u7684\u4eba\u8eab\u4e0a\u3002\u88ab\u8707\u8fc7\u591a\u6b21\u7684\u4eba\u5bf9\u8702\u6bd2\u8fc7\u654f\u7684\u53ef\u80fd\u6027\u8981\u5c0f\u5f97\u591a\u3002\u8fd9\u4e00\u89c2\u5bdf\u8bf4\u660e\u4e86\u6297\u539f\u7684\u5242\u91cf\u5982\u4f55\u8bf1\u5bfc\u8010\u53d7\u3002\u517b\u8702\u4eba\u7684\u4f34\u4fa3\u53ea\u63a5\u89e6\u4f4e\u5242\u91cf\u7684\u8702\u6bd2\uff0c\u5df2\u7ecf\u4ea7\u751f\u4e86T-Helper 2(TH2)\u7ec6\u80de\uff0c\u8fd9\u79cd\u7ec6\u80de\u523a\u6fc0B\u7ec6\u80de\u4ea7\u751f\u8702\u6bd2\u7279\u5f02\u6027\u514d\u75ab\u7403\u86cb\u767dE(IgE)\u3002IgE\u4f1a\u5f15\u8d77\u8fc7\u654f\u75c7\u72b6\uff08\u7b2c27\u7ae0\uff09\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u6211\u4eec\u7684\u517b\u8702\u4eba\u53cd\u590d\u7ecf\u5386\u7684\u523a\u75db\u6b63\u5728\u523a\u6fc0\u4ed6\u4ea7\u751f\u8c03\u8282\u6027T\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u5206\u6ccc\u767d\u7ec6\u80de\u4ecb\u7d2010(IL-10)\u6765\u56de\u5e94\u8702\u6bd2\uff0c\u5e76\u6291\u5236TH2\u7ec6\u80de\uff0c\u51cf\u5c11IgE\u7684\u4ea7\u751f\u3002\u9664\u4e86\u514d\u75ab\u8010\u53d7\u5916\uff0c\u53cd\u590d\u7684\u53ee\u54ac\u4e5f\u4f1a\u5bfc\u81f4\u4ee5TH2\u4e3a\u4e3b\u7684TH1\u53cd\u5e94\uff0c\u5373<\/span>\u514d\u75ab\u504f\u5dee\u3002\u7531\u4e8e\u5e72\u6270\u7d20-\u03b3\u5728TH1\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u5206\u6ccc\uff0c\u4fc3\u4f7f\u4ea7\u751f\u6297\u8702\u6bd2\u514d\u75ab\u7403\u86cb\u767d\uff0c\u4ece\u800c\u5bfc\u81f4\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n

\u53cd\u590d\u6297\u539f\u523a\u6fc0\u5bfc\u81f4\u514d\u75ab\u8010\u53d7\u548c\u514d\u75ab\u504f\u5dee\uff0c\u4fdd\u62a4\u6211\u4eec\u7684\u517b\u8702\u4eba\u3002\u7c7b\u4f3c\u7684\u8fc7\u7a0b\u4e5f\u7528\u4e8e\u4e34\u5e8a\u8fc7\u654f\u539f\u514d\u75ab\u6cbb\u7597\uff0c\u5982\u7b2c27\u7ae0<\/span>\u6240\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

Fig 18.4 <\/span>\u517b\u8702\u4eba\u5728\u590f\u5929\u591a\u6b21\u88ab\u8707\u6ca1\u6709\u4efb\u4f55\u53cd\u5e94\u3002\u59bb\u5b50\u88ab\u8707\u7684\u9891\u7387\u4f4e\uff0c\u4f46\u5df2\u6709\u4e25\u91cd\u7684\u53cd\u5e94<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

BOX 18.2<\/span>\u53e3\u670d\u8010\u53d7<\/span><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

\u53e3\u670d\u8010\u53d7\u662f\u901a\u8fc7\u53e3\u670d\u9014\u5f84\u9884\u5148\u7ed9\u4e88\u6297\u539f\u5bf9\u514d\u75ab\u53cd\u5e94\u7684\u7279\u5f02\u6027\u6291\u5236\u3002\u4eba\u7684\u80a0\u9053\u6bcf\u5929\u90fd\u5bb9\u7eb3\u5927\u91cf\u7684\u86cb\u767d\u3002\u5176\u4e2d\u5305\u62ec\u996e\u98df\u4e2d\u7684\u86cb\u767d\u8d28\uff0c\u4ee5\u53ca\u6765\u81ea\u751f\u6d3b\u5728\u80a0\u9053\u4e2d\u7684\u6570\u4e07\u4ebf\u79cd\u65e0\u5bb3\u5171\u751f\u7ec6\u83cc\u7684\u86cb\u767d\u8d28\u3002\u8fd9\u4e9b\u86cb\u767d\u8d28\u4e2d\u7684\u8bb8\u591a\u5728\u80a0\u8154\u5185\u4e0d\u80fd\u5b8c\u5168\u6d88\u5316\u6210\u6c28\u57fa\u9178\uff0c\u5b83\u4eec\u53ef\u4ee5\u86cb\u767d\u8d28\u6216\u591a\u80bd\u7684\u5f62\u5f0f\u88ab\u5438\u6536\u3002\u5bf9\u514d\u75ab\u7cfb\u7edf\u6765\u8bf4\uff0c\u8010\u53d7\u8fd9\u4e9b\u65e0\u5bb3\u7684\u6f5c\u5728\u6297\u539f\u662f\u5f88\u91cd\u8981\u7684\u3002<\/p>\n

\u80a0\u9053\u76f8\u5173\u6dcb\u5df4\u7ec4\u7ec7(GALT)\u4e0e\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u7684\u6dcb\u5df4\u7ec4\u7ec7\u4e0d\u540c\u3002\u80a0\u9053\u4e0a\u76ae\u7ec6\u80de\u4e0e\u65e0\u5bb3\u7684\u80a0\u9053\u7ec6\u83cc\u63a5\u89e6\u540e\u4f1a\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2(TGF-\u03b2)\u3002\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u5728\u80a0\u9053\u4e2d\u6709\u4e24\u4e2a\u91cd\u8981\u4f5c\u7528\u3002\u4e00\u65b9\u9762\uff0c\u5728\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u80a0\u9053\u6216\u80a0\u7cfb\u819c\u6dcb\u5df4\u7ed3\u4e2d\u7684\u5e7c\u7a1aT\u7ec6\u80de\u5728\u6297\u539f\u7684\u523a\u6fc0\u4e0b\u4f1a\u6210\u719f\u4e3a\u8bf1\u5bfcT\u8c03\u8282\u7ec6\u80de(iTregs)\u3002\u8fd9\u4f1a\u6291\u5236T\u7ec6\u80de\u5bf9\u6297\u539f\u7684\u53cd\u5e94\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u672a\u6210\u719f\u7684B\u7ec6\u80de\u5728\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\u5bf9\u80a0\u9053\u4e2d\u7684\u6297\u539f\u4ea7\u751f\u6297\u4f53\uff0c\u8f6c\u5411\u514d\u75ab\u7403\u86cb\u767dA\u7684\u5206\u6ccc\u3002(\u7b2c13\u7ae0<\/span>)IgA\u5728\u4fdd\u62a4\u7c98\u819c\u8868\u9762\u514d\u53d7\u611f\u67d3\u65b9\u9762\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5927\u591a\u6570\u75c5\u539f\u4f53\u90fd\u662f\u901a\u8fc7\u80a0\u9053\u8fdb\u5165\u4eba\u4f53\u7684\uff0c\u800cIgA\u5219\u8d77\u5230\u4e86\u963b\u6321\u8fd9\u4e9b\u75c5\u539f\u4f53\u7684\u4f5c\u7528\u3002\u4e0e\u5176\u4ed6\u7c7b\u522b\u7684\u6297\u4f53\u4e0d\u540c\uff0cIgA\u53ef\u4ee5\u9632\u6b62\u75c5\u539f\u4f53\u5165\u4fb5\u4eba\u4f53\u4e14\u4e0d\u4f1a\u5f15\u53d1\u592a\u591a\u7684\u5168\u8eab\u514d\u75ab\u53cd\u5e94\u3002\u56e0\u6b64\uff0cGALT\u5bf9\u6297\u539f\u7684\u53cd\u5e94\u662f\u901a\u8fc7\u4ea7\u751fiTregs\u548cIgA\uff0c\u800c\u4e0d\u662f\u901a\u8fc7\u523a\u6fc0\u6f5c\u5728\u5371\u9669\u7684\u5168\u8eab\u53cd\u5e94\u3002\u8fd9\u662f\u53e3\u670d\u8010\u53d7\u6027\u7684\u57fa\u7840\u3002<\/p>\n

\u7531\u4e8e\u5176\u5b89\u5168\u6027\u3001\u6613\u7ed9\u836f\u548c\u6297\u539f\u7279\u5f02\u6027\uff0c\u53e3\u670d\u8010\u53d7\u6027\u4f5c\u4e3a\u4e00\u79cd\u8bf1\u5bfc\u8010\u53d7\u6027\u7684\u624b\u6bb5\u5728\u4e34\u5e8a\u4e2d\u5df2\u88ab\u5e7f\u6cdb\u5e94\u7528\u3002\u4f8b\u5982\uff0c\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u963b\u65ad\u5bf9\u81ea\u8eab\u6297\u539f\u7684\u53cd\u5e94\u6216\u5728\u8fc7\u654f\u4e2d\u963b\u65ad\u5bf9\u73af\u5883\u6297\u539f\u7684\u53cd\u5e94\u3002\u5b83\u8fd8\u6709\u52a9\u4e8e\u8bf1\u5bfc\u5bf9\u7528\u4e8e\u6cbb\u7597\u7684\u86cb\u767d\u8d28\u7684\u8010\u53d7\u6027(\u4f8b\u5982\u7528\u4e8e\u6cbb\u7597\u8840\u53cb\u75c5\u7684\u56e0\u5b50VIII)\u3002<\/p>\n

\u5728\u52a8\u7269\u8eab\u4e0a\u8fdb\u884c\u7684\u5b9e\u9a8c\u663e\u793a\u51fa\u4e86\u5f88\u5927\u7684\u5e0c\u671b\u3002\u7136\u800c\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5728\u4eba\u4f53\u4e0a\u8fdb\u884c\u7684\u5927\u91cf\u4e34\u5e8a\u8bd5\u9a8c\u663e\u793a\u7684\u76ca\u5904\u5374\u975e\u5e38\u6709\u9650\u3002\u4f8b\u5982\uff0c\u5f53\u820c\u4e0b\u6ce8\u5c04\u8349\u82b1\u7c89(\u820c\u4e0b\u514d\u75ab\u7597\u6cd5\uff1b\u7b2c27\u7ae0<\/span>)\u65f6\uff0c\u82b1\u7c89\u70ed(T-helper 2[TH2]\u4ecb\u5bfc\u7684\u8349\u82b1\u7c89\u8fc7\u654f)\u53ef\u4ee5\u88ab\u963b\u65ad\u3002\u8fd9\u90e8\u5206\u662f\u7531iTregs\u4ecb\u5bfc\u7684\uff0c\u90e8\u5206\u662f\u901a\u8fc7\u5c06TH2\u7684\u53cd\u5e94\u5207\u6362\u5230TH1(\u514d\u75ab\u7f3a\u9677)\u6765\u5b9e\u73b0\u7684\u3002\u4eba\u7c7b\u53e3\u670d\u8010\u53d7\u7684\u53e6\u4e00\u4e2a\u4f8b\u5b50\u662f\u7ed9\u65e9\u671f1\u578b(\u80f0\u5c9b\u7d20\u4f9d\u8d56\u578b)\u7cd6\u5c3f\u75c5\u60a3\u8005\u53e3\u670d\u80f0\u5c9b\u7d20(\u7b2c28\u7ae0<\/span>)\u3002\u5728\u53e3\u670d\u80f0\u5c9b\u7d20\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4e00\u4e9b\u60a3\u8005\u8868\u73b0\u51fa\u7cd6\u5c3f\u75c5\u8fdb\u5c55\u5ef6\u8fdf\u7684\u8bc1\u636e\uff0c\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u8fd8\u9700\u8981\u5728\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |   \u738b\u60e0\u742a  \u9648\u6653\u610f<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u90d1\u68a6\u6021<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u9648\u79cb\u8c37 \u5b8b\u4e50<\/span><\/section>\n
\u7ec8\u5ba1 | \u738b\u5764<\/span> \u8096\u5efa\u52c7<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

<\/span><\/strong><\/section>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c17\u7ae0\uff1a\u514d\u75ab\u8bb0\u5fc6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7a33\u6001<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c16\u7ae0\uff1aT\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
<\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5373\u5c06\u5f00\u59cb\uff0c\u656c\u8bf7\u671f\u5f85\uff01<\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/span><\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span>
<\/p>\n

Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

QPCR\u5b9e\u9a8c\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a>
<\/p>\n

\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a>
<\/p>\n

\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a>
<\/p>\n

HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a>
<\/p>\n

PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
<\/p>\n

Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
<\/p>\n

\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a>
<\/p>\n

PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a><\/span><\/p>\n


<\/p>\n


<\/p>\n

\n
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\n
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\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u514d\u75ab\u7cfb\u7edf\u4e0d\u4ec5\u80fd\u591f\u9884\u9632\u548c\u62b5\u5fa1\u4e25\u91cd\u611f\u67d3\u3002\u5982\u7b2c35\u7ae0\u6240\u8ff0\uff0c\u5b83\u8fd8\u53ef\u4ee5\u5bf9\u6297\u80bf\u7624\u3002\u4e3a\u5b9e\u73b0\u8fd9\u4e9b\u76ee\u6807\uff0c\u514d\u75ab\u7cfb\u7edf\u5f62\u6210\u4e86\u5f3a\u6709\u529b\u7684\u6548\u5e94\u673a\u5236\u3002\u56e0\u6b64\u514d\u75ab\u7cfb\u7edf\u5931\u63a7\u4f1a\u9020\u6210\u76f8\u5f53\u5927\u7684\u635f\u5bb3\uff0c\u800c\u81ea\u8eab\u7684\u514d\u75ab\u5e94\u7b54\u5931…<\/p>\n","protected":false},"author":1,"featured_media":3564,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[58],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3572"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3572"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3572\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3564"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3572"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}