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\u6211\u4eec\u5728\u524d\u4e24\u7ae0\u4e2d\u5df2\u7ecf\u5b66\u4e60\u4e86\u80bf\u7624\u5fae\u73af\u5883<\/span><\/a>\u4ee5\u53ca\u80bf\u7624\u514d\u75ab\u6740\u4f24\u7684\u91cd\u8981\u6267\u884c\u8005-CD8+ <\/sup>T\u7ec6\u80de<\/span><\/a>\uff0c\u8fd9\u8fd9\u4e00\u7ae0\u4e2d\u6211\u4eec\u5c06\u5b66\u4e60\u6fc0\u6d3b\u6297\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u7684\u53e6\u4e00\u4e2a\u5fc5\u8981\u6761\u4ef6-\u80bf\u7624\u7a81\u53d8\u8868\u4f4d\uff0c\u5b83\u4e5f\u662f\u4eba\u4f53\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u7684\u91cd\u8981\u524d\u63d0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u764c\u75c7\u7684\u9776\u5411\u514d\u75ab\u6cbb\u7597\u662f\u4e00\u4e2a\u8fc5\u901f\u53d1\u5c55\u7684\u9886\u57df\uff0c\u5176\u53d1\u5c55\u5386\u53f2\u81f3\u5c11\u5df2\u7ecf\u8de8\u8d8a\u4e8630\u5e74\u7684\u5386\u53f2\u3002\u4ece\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f (TSA)\uff08\u4e0e\u8f6c\u5316\u7ec6\u80de\u5b8c\u5168\u76f8\u5173\u7684\u86cb\u767d\u8d28\u5206\u5b50\uff09\u7684\u9274\u5b9a\u548c\u8868\u5f81\u5f00\u59cb\uff0c\u4ee5\u53ca\u6700\u8fd1\u7531\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u6fc0\u6d3b\u7684\u65b0\u6297\u539f\u7279\u5f02\u6027\u514d\u75ab\u7ec6\u80de\u53cd\u5e94\u6027\u7684\u8bc1\u636e\uff0c\u8bc1\u660e\u4e86\u57fa\u4e8e\u514d\u75ab\u7684\u5e72\u9884\u63aa\u65bd\u5c06\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u5851\u9020\u764c\u75c7\u6cbb\u7597\u7684\u672a\u6765\u3002\u65b0\u6297\u539f\u6765\u81ea\u81ea\u7136\u5904\u7406\u7684\u5bbf\u4e3b\u7a81\u53d8\u86cb\u767d\u5206\u5b50–\u6700\u7ec8\u4ee5\u514d\u75ab\u539f\u6027\u80bd\u7684\u5f62\u5f0f\u5448\u9012\u7ed9\u514d\u75ab\u7cfb\u7edf\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u4e86\u89e3\u8bca\u65ad\u548c\u6cbb\u7597\u5e94\u7528\u4e2d\u7684\u514d\u75ab\u5b66\u548c\u751f\u7269\u5b66\u57fa\u7840\uff0c\u589e\u5f3a\u764c\u75c7\u60a3\u8005\u7684\u533b\u7597\u4fdd\u5065\uff0c\u5bf9\u65b0\u6297\u539f\u7684\u4ea7\u751f\u548c\u8bc6\u522b\u7684\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002<\/p>\n

\u5728\u672c\u7ae0\u4e2d\u6211\u4eec\u7b80\u8981\u5730\u5411\u8bfb\u8005\u4ecb\u7ecd\u4e86\u764c\u75c7\u4e2d\u7684\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012\u673a\u5236\uff0c\u5e76\u7b80\u8981\u63cf\u8ff0\u4e86\u764c\u75c7\u6297\u539f\u7684\u53d1\u73b0\u5386\u53f2\uff0c\u4ee5\u53ca\u4e00\u4e9b\u5f00\u521b\u6027\u7684\u53d1\u73b0\u3002\u6700\u540e\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u91cd\u70b9\u653e\u5728\u4e00\u4e9b\u65b0\u6297\u539f\u5bfc\u5411\u7684\u6cbb\u7597\u7b56\u7565\u4e0a\uff0c\u8fd9\u4e9b\u7b56\u7565\u5728\u4e34\u5e8a\u8f6c\u5316\u548c\u6cbb\u7597\u7684\u80cc\u666f\u4e0b\u53ef\u80fd\u4f1a\u5728\u672a\u6765\u7684\u4e00\u6bb5\u65f6\u95f4\u5185\u5f97\u5230\u6539\u8fdb\u3002\u6211\u4eec\u5c06\u672c\u7ae0\u7684\u5173\u6ce8\u91cd\u70b9\u653e\u5728\u764c\u75c7\u60a3\u8005\u7684\u4e3b\u52a8\u7ec6\u80de\u6cbb\u7597(ACT)\u4e0a\uff0c\u4ee5\u53ca\u5c06\u7a81\u53d8\u8868\u4f4d\u76f8\u5173\u6cbb\u7597\u7b56\u7565\u4e0e\u7ec6\u80de\u6cbb\u7597\u8054\u5408\u4f7f\u7528\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5229\u7528\u65b0\u6297\u539f\u8868\u4f4d\u7279\u5f02\u6027 T \u7ec6\u80de\u4e9a\u7fa4\u7684\u6f5c\u529b\u6765\u6740\u4f24\u80bf\u7624\u7684\u65b9\u6cd5\u975e\u5e38\u6709\u5438\u5f15\u529b\uff0c\u56e0\u4e3a\u5b83\u4eec\u80fd\u591f\u8bc6\u522b\u548c\u54cd\u5e94\u80bf\u7624\u7ec6\u80de\uff0c\u5177\u6709\u8f83\u5c0f\u7684\u8131\u9776\u6bd2\u6027\u4ee5\u53ca\u975e\u5e38\u9ad8\u7684\u6548\u7387\uff0c\u5e76\u4e14\u80fd\u591f\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u6301\u4e45\u7684\u548c\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u6cbb\u7597\u7ed3\u679c\u3002\u8fd9\u79cd\u9488\u5bf9\u8f6c\u5316\u7ec6\u80de\u7684\u6297\u764c\u53cd\u5e94\u672c\u8d28\u4e0a\u662f\u4e00\u79cd\u6709\u9488\u5bf9\u6027\u4e14\u5bcc\u6709\u6210\u6548\u7684\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\uff0c\u4f9d\u8d56\u4e8e\u80fd\u591f\u8bc6\u522b\u7a81\u53d8\u76ee\u6807\u7684T\u7ec6\u80de\u53d7\u4f53(TCR)\u8c31\u7cfb\u7684\u5b58\u5728\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u4e9b\u764c\u75c7\u6297\u539f\u56e0\u5176\u5728\u6076\u6027\/\u8f6c\u5316\u7ec6\u80de\u4e2d\u7684\u9009\u62e9\u6027\u7ec4\u7ec7\u8868\u8fbe\u6216\u8fc7\u5ea6\u8868\u8fbe\u800c\u88ab\u9274\u5b9a\u4e3a\u201c\u764c\u75c7\u6297\u539f\u201d\uff0c\u5982\u95f4\u76ae\u7d20\u6216\u764c-\u777e\u4e38\u6297\u539f(\u5c06\u5728\u672c\u7ae0\u540e\u9762\u8ba8\u8bba)\u3002\u5728\u5176\u4ed6\u60c5\u51b5\u4e0b\uff0c\u53d1\u751f\u5728\u5176\u4ed6\u6b63\u5e38\u8868\u8fbe\u548c\u529f\u80fd\u86cb\u767d\u4e2d\u7684\u7a81\u53d8\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5b83\u4eec\u6210\u4e3a\u81f4\u764c\u56e0\u5b50\u3002\u8fd9\u4e9b\u7a81\u53d8\u7684\u5bbf\u4e3b\u5206\u5b50\u53ef\u80fd\u53c2\u4e0e\u764c\u75c7\u7684\u542f\u52a8(\u81f4\u764c)\u3001\u75be\u75c5\u6301\u7eed<\/span>\u6216\u8f6c\u79fb\u3002\u7531\u4e8e\u67d0\u4e9b\u7a81\u53d8\u5bf9\u4e8e\u6076\u6027\u8f6c\u5316\u548c\u80bf\u7624\u7ec6\u80de\u5b58\u6d3b\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u6b64\u5b83\u4eec\u4e5f\u53ef\u80fd\u4fc3\u4f7f\u514d\u75ab\u9003\u9038\u7684\u53d1\u751f\uff0c\u901a\u8fc7\u4fc3\u8fdb\u80bf\u7624\u7684 T \u7ec6\u80de\u53cd\u5e94\uff0c\u6216 \u901a\u8fc7\u8bf1\u5bfc\u514d\u75ab\u529f\u80fd\u4e27\u5931\u6765\u201c\u81f4\u76f2\u201d\u6297\u764c\u514d\u75ab\u53cd\u5e94,\u6b64\u4e8c\u8005\u5e76\u975e\u76f8\u4e92\u6392\u65a5\uff0c\u53cd\u800c\u76f8\u4e92\u9002\u5e94\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u65b0\u7684\u764c\u75c7\u7814\u7a76\u53d1\u73b0\uff0c\u57fa\u4e8e\u514d\u75ab\u7684\u6cbb\u7597\u7684\u6210\u529f\u9700\u8981\u80fd\u591f\u8bc6\u522b\u7a81\u53d8\u9776\u70b9\u7684T\u7ec6\u80de\u53d7\u4f53\u8c31\u7cfb\u4ee5\u53ca\u6297\u764c\u7684\u7ec6\u80de\u514d\u75ab\u53cd\u5e94(\u4f8b\u5982\u7ec6\u80de\u6bd2\u6027\u53cd\u5e94\uff0cTh1\u578b\u514d\u75ab\u53cd\u5e94\uff0c\u89c1Fig4.1<\/span>)\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u57fa\u4e8eT\u7ec6\u80de\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6b63\u5728\u5feb\u901f\u53d1\u5c55\uff0c\u5f53\u524d\u9488\u5bf9\u5b9e\u4f53\u80bf\u7624\u7684\u6700\u6210\u529f\u7684\u65b0\u578b\u5e72\u9884\u63aa\u65bd\u662f\u4f9d\u8d56\u4e8e\u764c\u75c7\u7279\u5f02\u6027T\u7ec6\u80de\u6d3b\u6027\u53ca\u5176\u5728\u75be\u75c5\u90e8\u4f4d\u7684\u52a8\u5458\u6fc0\u6d3b\uff0c\u5373\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u3001\u5d4c\u5408\u6297\u539f\u53d7\u4f53(CARS<\/sub>)\u548cT\u7ec6\u80de\u53d7\u4f53(TCR)\u4fee\u9970\u7684T\u7ec6\u80de\u4e5f\u5c31\u662fCAR-T\u7597\u6cd5\u3002\u6297\u539f\u7279\u5f02\u6027\u80bf\u7624\u6d78\u6da6\u6027T\u6dcb\u5df4\u7ec6\u80de(TIL)\u7684\u5c40\u90e8\u6fc0\u6d3b\u53ef\u4ee5\u4f7f\u7ec6\u80de\u518d\u5faa\u73af\uff0c\u6709\u529b\u5730\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\uff0c\u51cf\u5c11\u80bf\u7624\u7ec6\u80de\u6570\u91cf\uff0c\u5e76\u5728\u7ec4\u7ec7\u4e2d\u534f\u8c03\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n

\u9488\u5bf9PD-1\u548cCTLA-4\u7684\u5355\u514b\u9686\u6297\u4f53\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u4e86\u9769\u547d\u6027\u7684\u53d8\u5316\uff0c\u6709\u8ff9\u8c61\u8868\u660e\uff0c\u5b83\u4eec\u6709\u53ef\u80fd\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u75c5\u6bd2\u6027\u809d\u708e\u3001\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2(HIV)\u611f\u67d3\u3001\u759f\u75be\u548c\u7ed3\u6838\u75c5\u7b49\u6162\u6027\u4f20\u67d3\u75c5\u3002\u7279\u522b\u662f\u6297 PD-1 \u7597\u6cd5\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u6fc0\u6d3b CD8+<\/sup> T \u7ec6\u80de\uff0c\u8be5\u7ec6\u80de\u5bf9\u4e0e\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u764c\u75c7\u8fdb\u5c55\u76f8\u5173\u7684\u7a81\u53d8\u6297\u539f\uff08\u65b0\u6297\u539f\uff09\u5177\u6709\u7279\u5f02\u6027\u3002\u5728\u514d\u75ab\u6cbb\u7597\u540e\u60a3\u8005\u8840\u6db2\u4e2d\u8868\u73b0\u51fa\u65b0\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de\u6570\u91cf\u7684\u6301\u4e45\u589e\u52a0\uff0c\u8fd9\u63d0\u793a\u4e86\u6297 PD-1 \u6cbb\u7597\u7684\u6f5c\u5728\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4.2 \u80bf\u7624\u4e2d\u7684\u6297\u539f\u52a0\u5de5\u548c\u63d0\u5448<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3\u63a8\u52a8\u6297\u539f\u4ea7\u751f\u548c\u5bf9\u514d\u75ab\u7cfb\u7edf\u201c\u53ef\u89c1\u6027\u201d\u7684\u52a8\u529b\u673a\u5236\uff0c\u6211\u4eec\u6709\u5fc5\u8981\u4e86\u89e3\u4e00\u4e9b\u5173\u4e8e\u6297\u539f\u5904\u7406\u548c\u5448\u9012\u7ed9\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7684\u4e00\u4e9b\u77e5\u8bc6\u3002\u6297\u539f\u5728\u81ea\u7136\u6761\u4ef6\u4e0b\u53ef\u4ee5\u5206\u4e3a\u5185\u6e90\u6027\u7684\u6216\u5916\u6e90\u6027\u7684\uff1b\u5b83\u4eec\u5728\u7ec6\u80de\u5185\u7ecf\u8fc7\u751f\u5316\u5904\u7406\uff0c\u5448\u73b0\u7ed9\u5404\u79cdT\u7ec6\u80de\u4e9a\u7fa4\u3001B\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24(NK)\u7ec6\u80de\u3002\u4e0e\u5411\u514d\u75ab\u7cfb\u7edf\u5448\u9012\u6297\u539f\u76f8\u5173\u7684\u57fa\u672c\u5206\u5b50\u88ab\u79f0\u4e3a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\uff0c\u5728\u4eba\u7c7b\u4f53\u5185\u79f0\u4e3a\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f(HLA)\u3002MHC\/HLA\u7cfb\u7edf\u7684\u529f\u80fd\u662f\u7531Rolf Zinkernagel\u548cPeter Doherty\u572820\u4e16\u7eaa70\u5e74\u4ee3\u521d\u53d1\u73b0\u5e76\u9996\u6b21\u63cf\u8ff0\u7684\uff0c\u8fd9\u9879\u5f00\u521b\u6027\u7684\u5de5\u4f5c\u4f7f\u4ed6\u4eec\u57281996\u5e74\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u533b\u5b66\u548c\u751f\u7406\u5b66\u5956\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig.4.1<\/span> \u4ece\u8f6c\u5316\u7ec6\u80de\u4e2d\u8bc6\u522b\u7a81\u53d8\u8868\u4f4d\u7684\u7b56\u7565\uff0cCSF\uff1a\u8111\u810a\u6db2<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Th1\/Th2\u5e94\u7b54\u4ee5\u53caMHC\u7684\u9650\u5236\u6027<\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n
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Th2\u578bT\u7ec6\u80de\u53cd\u5e94\u672c\u8eab\u53ef\u80fd\u5e76\u4e0d\u610f\u5473\u7740\u6291\u5236\u6027\u548c\u6f5c\u5728\u7684\u201c\u8010\u53d7\u6027\u201d\u514d\u75ab\u53cd\u5e94\uff1b\u6700\u8fd1\u7684\u62a5\u9053\u8868\u660eTh2\u578b\u514d\u75ab\u53cd\u5e94\u4e5f\u53ef\u80fd\u4ecb\u5bfc\u4ea7\u751f\u4e34\u5e8a\u76f8\u5173\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u6297\u539f\u7279\u5f02\u6027Th2\u7ec6\u80de\u5728\u6ca1\u6709CD8T\u7ec6\u80de\u7684\u5e2e\u52a9\u4e0b\u6839\u9664\u4e86\u9aa8\u9ad3\u7624\uff0c\u5bfc\u81f4\u4e86\u80bf\u7624\u90e8\u4f4d\u7684\u5927\u8303\u56f4\u708e\u75c7\u3002\u7814\u7a76\u8868\u660e\uff0cTh2\u4ecb\u5bfc\u7684\u80bf\u7624\u7834\u574f\u4e0e\u539f\u4f4d\u4ea7\u751f\u7684IL-1\u3001TNF-\u03b1(Th1)\u548cTh2\u7ec6\u80de\u56e0\u5b50(IL-4\u3001IL-5\u3001IL-13)\u6709\u5173\uff0c\u800c\u88ab\u52a8\u8f6c\u79fb\u7684Th2\u7ec6\u80de\u80fd\u591f\u4ea7\u751f\u6301\u4e45\u7684\u7ec6\u80de\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u5728Th2\u4ecb\u5bfc\u7684\u514d\u75ab\u5e94\u7b54\u4e2d\uff0cCD8\u975e\u4f9d\u8d56\u6027\u548c\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u662f\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8d8b\u5316\u56e0\u5b50(Eotaxin)\u548cSTAT6\u4f9d\u8d56\u6027\u7684T\u7ec6\u80de\u3002\u800c\u4eba\u7c7b\u764c\u75c7\u4e2d\u7684Th2\u6d78\u6da6\u8fd8\u6ca1\u6709\u5f97\u5230\u5e7f\u6cdb\u7684\u7814\u7a76\uff0c\u4e00\u4e9b\u7814\u7a76\u751a\u81f3\u8868\u660e\u4f7f\u7528Th2\u578b\u7ec6\u80de\u56e0\u5b50\u4f1a\u4ea7\u751f\u66f4\u597d\u7684\u514d\u75ab\u7ed3\u679c\u3002Th2\u53cd\u5e94\u5728\u8bc6\u522b\u7a81\u53d8\u8868\u4f4d\u65b9\u9762\u7684\u5b9e\u8d28\u76ee\u524d\u8fd8\u6ca1\u6709\u5f97\u5230\u5f88\u597d\u7684\u7814\u7a76\u3002CD4-Th2\u53cd\u5e94\u4e4b\u95f4\u7684\u5173\u8054\u4e5f\u53ef\u80fd\u53d7\u76ca\u4e8eT\u7ec6\u80de\u4e0e\u9650\u5236\u6027\u7684MHC II\u7c7b\u5206\u5b50\u7684\u66f4\u5bc6\u5207\u7684\u5173\u8054\u3002\u4f8b\u5982\uff0c\u4ee5\u524d\u7684\u7814\u7a76\u62a5\u9053\uff0c\u5728DPB1*0401\/0402\u9633\u6027\u7684\u5375\u5de2\u764c\u60a3\u8005\u4e2d\uff0cTh1\/Th2 CD4+<\/sup>T\u7ec6\u80de\u5bf9NY-ESO-1\u6709\u53cd\u5e94\u3002\u800c\u66f4\u591a\u7684\u4fe1\u606f\u662f\u5173\u4e8e\u9488\u5bf9\u6765\u81ea\u611f\u67d3\u6027\u75c5\u539f\u4f53\u7684\u76f8\u5bf9\u8f83\u5c11\u53d8\u5f02(\u4e0eHLA-DR\u76f8\u6bd4)\u7684HLA-DP\u5206\u5b50\u6240\u5448\u73b0\u7684\u591a\u80bd\u7684\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u7684\u6027\u8d28\uff0c\u4f8b\u5982\u4e59\u578b\u809d\u708e\u6216MHC II\u7c7b\u5206\u5b50\uff0c\u5b83\u4eec\u4f7f\u4eba\u7c7b\u5bb9\u6613\u60a3\u4e0a\u67d0\u4e9b\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5(\u4f8b\u5982\u9eb8\u8d28\u76f8\u5173\u6027\u7ed3\u80a0\u708e)\u3002\u67d0\u4e9bMHC\u7b49\u4f4d\u57fa\u56e0\u4e0e\u67d0\u4e9b\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u6a21\u5f0f(IL-17\u3001Th1\u3001Th2)\u76f8\u5173\u7684\u53d8\u5f02\u8868\u4f4d\u7684\u5f71\u54cd\u5230\u76ee\u524d\u4e3a\u6b62\u5c1a\u4e0d\u6e05\u695a\u3002Table.4.1<\/span>\u63d0\u4f9b\u4e86\u4ece\u80f6\u8d28\u7624\u60a3\u8005\u7684TIL\u4e2d\u8bc6\u522b\u7684\u91ce\u751f\u578b\u548c\u7a81\u53d8\u578b\u9776\u8868\u4f4d\u7684\u6982\u8ff0\uff0c\u8868\u660e\u9488\u5bf9\u7a81\u53d8\u578b\u8868\u4f4d\u7684\u5355\u4e2a\u60a3\u8005\u7684TCR\u8c31\u7cfb\u4e2d\u5b58\u5728Th2\u53cd\u5e94\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u65b0\u6297\u539f\u7684\u52a0\u5de5\u548c\u5448\u9012\u53ef\u80fd\u4f1a\u4ea7\u751f\u7a81\u53d8\u8868\u4f4d(\u65b0\u8868\u4f4d)\uff0c\u8fd9\u4e9b\u8868\u4f4d\u65e2\u662f\u5171\u4eab\u7684\uff0c\u4e5f\u662f\u60a3\u8005\u7279\u6709\u7684\u3002\u8fd9\u5f53\u7136\u53d6\u51b3\u4e8e\u7a81\u53d8\u7684\u4f4d\u7f6e\uff0c\u5373\u53ef\u80fd\u7834\u574f\u81ea\u7136\u53d1\u751f\u7684\u88c2\u89e3\u4f4d\u70b9\u7684\u70b9\u7a81\u53d8\uff0c\u4ee5\u53ca\u7a81\u53d8\u672c\u8eab\u7684\u6027\u8d28\uff0c\u5373\u70b9\u7a81\u53d8\u3001\u67d3\u8272\u4f53\u7f3a\u5931\u548c\u8fc7\u65e9\u7ec8\u6b62\u5bc6\u7801\u5b50\u3002\u4f7f\u7528\u4ece\u4ee3\u886820\u79cd\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u60a3\u8005\u7684\u80bf\u7624\u548c\u975e\u80bf\u7624\u7ec4\u7ec7\u4e2d\u63d0\u53d6\u7684DNA\uff0c\u5bf9HLA-I\u7c7b\u9014\u5f84\u4e2d\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u8fdb\u884c\u7efc\u5408\u5206\u6790\uff0c\u53d1\u73b0HLA-I\u7c7b\u5206\u5b50\u7684N\u7aef\u53d1\u751f\u529f\u80fd\u4e27\u5931\u7a81\u53d8\u7684\u53ef\u80fd\u6027\u5f88\u9ad8\uff0c\u5b83\u963b\u6b62\u4e86\u591a\u80bd-HLA\u590d\u5408\u7269\u5411\u7ec6\u80de\u8868\u9762\u7684\u8fd0\u8f93\u3002\u6b64\u5916\uff0c\u5728\u6240\u6709\u88ab\u6d4b\u8bd5\u7684\u764c\u75c7\u4e2d\uff0c\u53d1\u73b0\u6700\u5e38\u89c1\u7684\u7a81\u53d8\u53d1\u751f\u5728HLAI\u7c7b\u5206\u5b50\u7684CD8-TCR 3\u533a\u57df\uff0c\u8fd9\u4e00\u7a81\u53d8\u662f\u5728\u514d\u75ab\u7a81\u89e6\u8fc7\u7a0b\u4e2dT\u7ec6\u80de\u4e0a\u7684\u03b1\u5171\u540c\u53d7\u4f53\u7ed3\u5408\u6240\u5fc5\u9700\u7684\uff0c\u901a\u8fc7\u8be5\u7a81\u53d8\u4ece\u800c\u6fc0\u6d3bCD8-TCR\u590d\u5408\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table.4.1<\/span> \u9488\u5bf9\u91ce\u751f\u578b\u548c\u7a81\u53d8\u578b\u8868\u4f4d\u7684TIL-Th1\u548cTh2\u6a21\u5f0f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

4.3 \u80bf\u7624\u6297\u539f\u548c\u8868\u4f4d\uff1a\u4ece\u53d1\u73b0\u5230\u6cbb\u7597\u5e94\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n

\u4eba\u7c7b\u764c\u75c7\uff0c\u7279\u522b\u662f\u9ed1\u8272\u7d20\u7624\u5c0f\u9f20\u6a21\u578b\u7684\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u5728\u80bf\u7624\u6392\u65a5\u7684\u80cc\u666f\u4e0b\uff0c\u63d0\u4f9b\u4e86\u5bf9\u764c\u75c7\u6297\u539f\u53d1\u73b0\u548c\u529f\u80fd\u7279\u5f81\u7684\u7b2c\u4e00\u6b21\u5b9e\u9a8c\u89c2\u5bdf\u3002Thierry Boon\u53ca\u5176\u540c\u4e8b\u572820\u4e16\u7eaa80\u5e74\u4ee3\u672b\u66fe\u8bc1\u660e\uff0c\u5728\u5c0f\u9f20P815\u80bf\u7624\u7ec6\u80de\u4e2d\u5f02\u6e90\u8868\u8fbe\u7684\u80bf\u7624\u6297\u539fP19A(\u4ece\u643a\u5e26\u7532\u57fa\u80c6\u84bd\u8bf1\u5bfc\u7684\u8089\u7624\u7684DBA\/2\u5c0f\u9f20\u4e2d\u5206\u79bb\u51fa\u6765)\u5305\u542b\u4e00\u4e2aHLA-I\u7c7b\u8868\u4f4d(\u4f4d\u4e8e\u4e00\u4e2a\u542b\u6709\u70b9\u7a81\u53d8\u768413\u805a\u4f53\u5e8f\u5217\u4e2d)\uff0c\u80fd\u591f\u5f15\u53d1\u6709\u6548\u7684CTL\u53cd\u5e94\u548c\u9776\u7ec6\u80de\u7684\u88c2\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7531\u6b27\u6d32\u548c\u7f8e\u56fd\u7684\u7814\u7a76\u5c0f\u7ec4\u5e26\u5934\uff0c\u9996\u5148\u4f7f\u7528\u4ece\u4eba\u7c7b\u9ed1\u8272\u7d20\u7624\u75c5\u53d8\u4e2d\u63d0\u53d6\u7684\u80bf\u7624\u7ec4\u7ec7\uff0c\u5728\u4eba\u7c7b\u764c\u75c7\u73af\u5883\u4e2d\u8fdb\u884c\u8868\u4f4d\u6316\u6398\u3002\u6bd4\u5229\u65f6\u5e03\u9c81\u585e\u5c14\u8def\u5fb7\u7ef4\u5e0c\u7814\u7a76\u6240(Ludwig Institute)\u7684\u8482\u57c3\u91cc\u00b7\u5e03\u6069(Thierry Boon)\u3001\u76ae\u57c3\u5c14\u00b7\u5e93\u5229(Pierre Coulie)\u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u4e8e1991\u5e74\u53d1\u73b0\u4e86\u7b2c\u4e00\u4e2a\u80bf\u7624\u76f8\u5173\u6297\u539f(TAA)\uff0c\u88ab\u4e00\u682a\u81ea\u4f53CTL\u682a\u8bc6\u522b\uff0c\u5e76\u8bf1\u5bfc\u8868\u8fbeMAGE-1DNA\u7684\u80bf\u7624\u7ec6\u80de\u682a\u88c2\u89e3\uff0c\u5e76\u53d7\u5230HLA-A1\u7684\u9650\u5236\u3002\u6b64\u524d\u4ed6\u4eec\u4f7f\u7528\u6765\u81ea\u4e00\u4f4d\u60a3\u6709\u8f6c\u79fb\u6027\u75be\u75c5\u7684\u533f\u540d\u60a3\u8005MZ2\u7684\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u682a\u4f53\u5916\u9274\u5b9a\u4e86CTL\u53cd\u5e94\u3002\u8fd9\u79cdTAA\u6700\u521d\u88ab\u6ce8\u91ca\u4e3aMZ2-E\uff0c\u540e\u6765\u66f4\u540d\u4e3a\u9ed1\u8272\u7d20\u7624\u76f8\u5173\u6297\u539f1(MAGE-1\uff0c\u764c\u75c7\u777e\u4e38\u6297\u539f)\u3002\u901a\u8fc7\u5bf9\u540c\u4e00\u60a3\u8005\u7684\u7ec6\u80de\u7cfb\u7684\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u4ed6\u4eec\u53d1\u73b0\u4e86MZ2F\uff0c\u4e5f\u5c31\u662f\u4eca\u5929\u6240\u77e5\u7684G\u6297\u539f1(GAGE-1)\u3002\u5f53\u65f6\u6b63\u5728\u8fdb\u884c\u7684\u5927\u90e8\u5206\u5de5\u4f5c\u96c6\u4e2d\u5728\u53d1\u73b0\u65b0\u7684\u514d\u75ab\u539f\u6027HLA -I\u7c7b\u9650\u5236\u6027\u6297\u539f\uff0c\u8fd9\u4e9b\u6297\u539f\u4ecb\u5bfc\u4e86\u60a3\u8005\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684CTL\u53cd\u5e94\u548c\u6eb6\u89e3\uff0c\u4eba\u4eec\u6709\u6d53\u539a\u7684\u5174\u8da3\u9996\u5148\u4e86\u89e3\u5176\u673a\u5236\u5e76\u5f00\u53d1\u57fa\u4e8e\u514d\u75ab\u7684\u5e72\u9884\u63aa\u65bd\uff1aMAGE-3.A1\u80bd\u514d\u75ab\u60a3\u8005\u4e2d\u7684Melan-A(HLA-A2+\u8868\u4f4d)\u548cMAGE-3(HLA-A1+\u8868\u4f4d)\u7279\u5f02\u6027CTL\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
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\n

\u6b27\u6d32\u548c\u7f8e\u56fd\u7684\u7814\u7a76\u4eba\u5458\u540c\u65f6\u53d1\u73b0\u4e86\u53e6\u4e00\u79cd\u91cd\u8981\u7684\u764c\u75c7\u6297\u539f\u2014\u764c\u75c7\u777e\u4e38\u6297\u539fNY-ESO-1\uff0c\u5b83\u662f\u7528\u4ece\u4eba\u98df\u7ba1\u9cde\u764c\u7ec6\u80de\u5236\u5907\u7684cDNA\u5bf9\u8868\u8fbecDNA\u6587\u5e93(SEREX)\u8fdb\u884c\u8840\u6e05\u5b66\u5206\u6790(\u8868\u660e\u5b58\u5728\u6297\u4f53\u53cd\u5e94)\u800c\u53d1\u73b0\u7684\u3002Elke J\u00e4ger\u548c\u4ed6\u7684\u540c\u4e8b(\u6cd5\u5170\u514b\u798f)\u540e\u6765\u53d1\u73b0NY-ESO-1\u542b\u6709\u5177\u6709\u751f\u7269\u5b66\u529f\u80fd\u7684CD8+<\/sup>(HLA-A2\/B51)\u548cCD4+<\/sup>(HLA-DRB*1)T\u7ec6\u80de\u8868\u4f4d\uff0c\u8fd9\u4e9b\u53d1\u73b0\u662f\u57fa\u4e8e\u5bf9\u4eba\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u548c\u8f6c\u67d3T2\u7ec6\u80de\u7684\u7cbe\u6db2\u7814\u7a76\u3002\u4e0a\u8ff0T2\u7ec6\u80de\u5728\u4e0e\u6297\u539f\u5904\u7406(TAP)\u76f8\u5173\u7684\u8f6c\u8fd0\u4f53\u4e2d\u5b58\u5728\u7f3a\u9677\uff0c\u4ece\u800c\u6291\u5236\u5b83\u4eec\u5448\u9012\u5185\u6e90\u6027\u80de\u6d46\u591a\u80bd(\u9664\u4e86\u4e00\u4e9b\u88c5\u8f7d\u5728HLA-A2\u5206\u5b50\u4e0a\u7684\u524d\u5bfc\u80bd\u5e8f\u5217)\uff0c\u4f46\u5141\u8bb8\u5f15\u5165\u5916\u6e90\u6dfb\u52a0\u7684HLA-I\u7c7b\u8868\u4f4d\u7528\u4e8eCTL\u8bc6\u522b\u8bd5\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53f2\u8482\u6587\u00b7\u7f57\u68ee\u4f2f\u683c(Steven Rosenberg)\u548c\u4ed6\u5728\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240(NCI\uff0cNational Institutes of Health(NIH)\uff0cBethesda\uff0cMD)\u5916\u79d1\u5206\u9662\u7684\u540c\u4e8b\u5bf9\u4eba\u7c7b\u9ed1\u8272\u7d20\u7624\u6297\u539f\u7684\u53d1\u73b0\u505a\u51fa\u4e86\u5173\u952e\u8d21\u732e\uff0c\u7279\u522b\u662f\u53d1\u73b0\u4e86\u4e00\u4e9b\u8bf1\u5bfcTIL\u4e4b\u95f4\u7684\u53cd\u5e94\u6027\u7684\u6297\u539f\uff1a1995\u5e74\u53d1\u73b0\u7531HLA-A31\u5206\u5b50\u9650\u5236\u7684\u916a\u6c28\u9178\u76f8\u5173\u86cb\u767d1(Trp-1)\u6216gp75\uff1bHLA-A31\u9650\u5236\u6027Trp-2\u80bdLLPGGRPYR\uff0c\u5b83\u662fTIL\u8f93\u5165\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u4e3b\u8981\u9776\u70b9\uff0c\u540e\u6765\u7528\u4e8e\u663e\u793a\u75be\u75c5\u6d88\u9000\u7a0b\u5ea6\uff1b\u7531HLA-A31\u548cHLA-A33\u9650\u5236\u7684Trp-1\u548cTrp-2(TRP197-205)\u8868\u4f4d\uff1b\u7531HLA-DR1\u9650\u5236\u7684\u78f7\u9178\u4e19\u7cd6\u5f02\u6784\u9176\u4ea7\u751f\u7684\u7a81\u53d8\u8868\u4f4d\uff0c\u7531CD4+<\/sup>TIL\u548c\u7ec6\u80de\u5206\u88c2\u5468\u671f\u86cb\u767d27\u540c\u7cfb\u7269(CDC27)\u8bc6\u522b\u3002\u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u4e9b\u65e9\u671f\u7684\u7814\u7a76\u52aa\u529b(\u4ece20\u4e16\u7eaa80\u5e74\u4ee3\u672b\u523021\u4e16\u7eaa\u521d\u768415\u5e74\u95f4)\u4e3a\u672a\u6765\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6781\u597d\u7684\u57fa\u7840\uff0c\u8fdb\u4e00\u6b65\u63a8\u52a8\u9776\u5411\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u6269\u5927\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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20\u4e16\u7eaa90\u5e74\u4ee3\u540e\u671f\u5b9e\u65bd\u7684\u5de5\u4f5c\u5c06\u66f4\u591a\u7684\u91cd\u70b9\u653e\u5728\u7814\u7a76\u4eba\u7c7b\u764c\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u86cb\u767d\uff0c\u4ee5\u53ca\u53d1\u73b0\u7531HLA\u9650\u5236\u6027\u5143\u4ef6\u5448\u73b0\u7684\u5177\u6709\u751f\u7269\u5b66\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u7a81\u53d8\u6297\u539f\u51b3\u5b9a\u7c07(\u65b0\u8868\u4f4d)\u5728\u4e34\u5e8a\u514d\u75ab\u6cbb\u7597\u7684\u53ef\u80fd\u6027\u3002\u4e00\u4e2a\u65e9\u671f\u7684\u4f8b\u5b50\u662f\u9ed1\u8272\u7d20\u7624\u65e0\u5904\u4e0d\u5728\u7684\u7a81\u53d81\u86cb\u767d(MUM-1\uff0c\u6700\u521d\u547d\u540d\u4e3aLB33-B\uff0c\u4ee5\u9ed1\u8272\u7d20\u7624\u60a3\u8005LB33\u7684\u540d\u5b57\u547d\u540d)\u4e0a\u7684\u65b0\u8868\u4f4d\uff0c\u8be5\u8868\u4f4d\u53d7HLA-B*44*02\u7b49\u4f4d\u57fa\u56e0\u7684\u9650\u5236\u3002\u8be59\u805a\u4f53\u65b0\u8868\u4f4d\u662f\u5728\u5bf9\u81ea\u4f53\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7cfbLB33-MEL.A-1\u8fdb\u884c\u4f53\u5916\u7ec6\u80de\u6bd2\u6027\u5b9e\u9a8c\u540e\u786e\u5b9a\u7684\uff1b\u800c\u5728\u91ce\u751f\u578b\u591a\u80bd\u5e8f\u5217\u4e2d\u6ca1\u6709\u53d1\u73b0\u6709\u4e0e\u5176\u76f8\u540c\u7684\u7ec6\u80de\u6740\u4f24\u6d3b\u6027\u7684\u8868\u4f4d\u3002\u7a81\u53d8\u7ec6\u80de\u7684\u7ec6\u80de\u5468\u671f\u53d7\u7ec6\u80de\u5468\u671f\u7d20\u4f9d\u8d56\u6027\u6fc0\u91764(CDK4R24C)\u86cb\u767d\u768410\u805a\u4f53\u65b0\u8868\u4f4d(\u6c28\u57fa\u917823-32)\u53d7HLA-A*0201\u9650\u5236\uff0c\u5728\u8f6c\u67d3CDK4R24C cDNA\u7684T2\u7ec6\u80de\u4f5c\u7528\u4e0b\uff0c\u53ef\u901a\u8fc7\u81ea\u4f53CTL\u4ecb\u5bfc\u7ec6\u80de\u6740\u4f24\u6d3b\u6027\uff0c\u4e14\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u800cHLA-B*3503\u9650\u5236\u6027\u534a\u80f1\u6c28\u9178\u5929\u51ac\u6c28\u9178\u86cb\u767d\u91768(Caspase8)\u7a81\u53d8\u80bd\u5bf9\u81ea\u4f53\u5934\u9888\u764c\u7ec6\u80de\u548c\u8f6c\u67d3\u80bf\u7624cDNA\u7684B\u7ec6\u80de\u5177\u6709\u8f83\u5f3a\u7684\u6740\u4f24\u6d3b\u6027\u3002\u8fd9\u4e9b\u7814\u7a76\u8fdb\u4e00\u6b65\u6269\u5927\u4e86\u4ece\u4eba\u764c\u7ec6\u80de\u4e2d\u6316\u6398\u65b0\u8868\u4f4d\u7684\u7814\u7a76\u9886\u57df\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bf9\u4ee3\u886830\u79cd\u4e0d\u540c\u4eba\u7c7b\u764c\u75c7\u7684\u4e34\u5e8a\u80bf\u7624\u6837\u672c\u7684\u6574\u4e2a\u57fa\u56e0\u7ec4\u548c\u5916\u5468DNA\u7684\u9ad8\u901a\u91cf\u5206\u6790\u63ed\u793a\u4e86\u6bcf\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u72ec\u7279\u7684\u7a81\u53d8\u8d1f\u8377\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u764c\u75c7\u7279\u6709\u7684\u7a81\u53d8\u7279\u5f81\u3002\u867d\u7136\u8fd9\u63d0\u4f9b\u4e86\u4eba\u7c7b\u764c\u75c7\u4e2d\u7a81\u53d8\u8d1f\u8377\u7684\u603b\u4f53\u56fe\u8c31\uff0c\u4f46\u6bcf\u4e2a\u60a3\u8005\u7684\u7a81\u53d8\u7279\u5f81\u662f\u4e0d\u540c\u7684-\u56e0\u6b64\u4ea7\u751f\u4e86\u4e00\u4efd\u79c1\u4eba\u7a81\u53d8\u7279\u5f81\u7684\u201c\u6982\u8981\u201d\uff0c\u8fd9\u4e9b\u7a81\u53d8\u7279\u5f81\u4e0d\u4ec5\u6d89\u53ca\u9a71\u52a8\u548c\u7ef4\u6301\u6076\u6027\u8f6c\u5316\uff0c\u800c\u4e14\u6d89\u53ca\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u6269\u589e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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V-Ki-ras2Kirsten\u5927\u9f20\u8089\u7624\u75c5\u6bd2\u764c\u57fa\u56e0\u662f\u5176\u540c\u6e90\u57fa\u56e0\u7684\u7a81\u53d8\u5f62\u5f0f\uff0c\u7b80\u79f0KRAS\uff0c\u662f\u4e00\u79cd\u516c\u8ba4\u7684\u65b0\u6297\u539f\uff0c\u4e0e\u80f0\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u548c\u80ba\u764c\u7684\u53d1\u75c5\u6709\u5173\u3002\u5929\u7136KRAS\u662f1982\u5e74\u5728\u4eba\u7c7b\u80ba\u817a\u764c\u57fa\u56e0\u6d4b\u5e8f\u540e\u53d1\u73b0\u7684\uff0c\u662f\u4e00\u79cd\u53c2\u4e0e\u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\u7684\u9e1f\u560c\u5464\u4e09\u78f7\u9178\u9176\uff1b\u7136\u800c\u517612\u300113\u548c16\u4f4d\u7684\u7a81\u53d8\u4e0e\u80bf\u7624\u7684\u53d1\u751f\u6709\u5173\uff0c\u4ece\u800c\u4f7f\u5176\u6210\u4e3a\u4eba\u7c7b\u7684\u539f\u764c\u57fa\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662(Bethesda\uff0cMD)\u5916\u79d1\u5206\u90e8\u7684Steven Rosenberg\u548c\u4ed6\u7684\u540c\u4e8b\u6700\u8fd1\u5f00\u53d1\u4e86\u4e00\u79cd\u5c16\u7aef\u65b9\u6cd5\uff0c\u4e3a\u4e2a\u522b\u60a3\u8005\u7b5b\u9009\u53ef\u4ee5\u8bc6\u522b\u65b0\u8868\u4f4d\u7684\u65b0\u8868\u4f4d\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u3002\u8fd9\u79cd\u65b9\u6cd5\u88ab\u79f0\u4e3a\u201c\u4e32\u8054\u5fae\u57fa\u56e0(TMG)\u201d\u65b9\u6cd5\uff0c\u5b83\u9996\u5148\u9700\u8981\u4ece\u60a3\u8005\u80bf\u7624\u7ec4\u7ec7\u6837\u672c\u4e2d\u63d0\u53d6\u7684\u57fa\u56e0\u7ec4DNA\u7684\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\u6570\u636e\u3002\u800c\u6d4b\u5e8f\u6570\u636e\u4f1a\u4ea7\u751f\u75c5\u4eba\u57fa\u56e0\u7f16\u7801DNA\u4e2d\u5305\u542b\u7684\u6240\u6709\u975e\u4f53\u7ec6\u80de\u7a81\u53d8\uff0c\u8fd9\u6837\u5c31\u53ef\u4ee5\u6784\u5efa\u4e00\u4e2a\u60a3\u8005\u201c\u79c1\u4eba\u201d\u7a81\u53d8\u7684\u4e2a\u4eba\u6587\u5e93\uff0c\u800c\u8fd9\u4e9b\u7a81\u53d8\u53ef\u80fd\u7f16\u7801\u65b0\u8868\u4f4d\u3002\u7136\u540e\uff0c\u901a\u8fc7\u4eba\u5de5\u628a\u8fd9\u4e9b\u77ed\u57fa\u56e0\u5e8f\u5217\u6784\u5efa\u5728\u4e00\u8d77\uff0c\u5e76\u63d2\u5165\u5230\u8868\u8fbe\u8d28\u7c92\u4e2d\uff0c\u8be5\u8868\u8fbe\u8d28\u7c92\u968f\u540e\u88ab\u8f6c\u67d3\u5230\u6162\u75c5\u6bd2\u8f7d\u4f53\u4e2d\uff0c\u7528\u4e8e\u611f\u67d3APC\uff08\u6765\u81ea\u60a3\u8005\u7684\u6811\u7a81\u72b6\u7ec6\u80de)\u3002\u7136\u540e\uff0c\u5c06\u6765\u81ea\u540c\u4e00\u60a3\u8005\u7684\u81ea\u4f53TIL\u4e0e\u643a\u5e26TMG\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u5171\u57f9\u517b\uff0c\u4ee5\u8bf1\u5bfc\u514d\u75ab\u53cd\u5e94\u3002\u4ee5TIL\u4ea7\u751f\u5e72\u6270\u7d20-\u03b3\u4e3a\u4ee3\u8868\u7684\u9633\u6027\u53cd\u5e94\u5c06\u6807\u5fd7\u7740\u5171\u57f9\u517b\u7684DC\u542b\u6709TMG\uff0c\u8be5TMG\u5305\u62ec\u4e00\u4e2a\u65b0\u7684\u8868\u4f4d\u7f16\u7801\u5e8f\u5217\uff0c\u8be5\u5e8f\u5217\u4f1a\u88ab\u81ea\u7136\u5904\u7406\u5e76\u5448\u9012\u7ed9\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u4e8e\u7a81\u53d8\u8868\u4f4d\u786e\u5b9e\u4f1a\u88ab\u5904\u7406\u5e76\u5448\u9012\u7ed9T\u7ec6\u80de\u7684\u524d\u63d0\u6761\u4ef6\uff0c\u4e0d\u540c\u79cd\u7684\u4f1a\u5bf9\u7a81\u53d8\u4ea7\u751f\u54cd\u5e94\u7684T\u7ec6\u80de\u7fa4\u4f53\u53ef\u80fd\u4f1a\u5bf9\u8be5\u7a81\u53d8\u4ea7\u751f\u4e0d\u540c\u7684\u3001\u4e92\u4e0d\u6392\u65a5\u7684\u5f71\u54cd\uff1a(1)\u65b0\u62db\u52df\u7684T\u7ec6\u80de\u5c06\u7279\u5f02\u6027\u8bc6\u522b\u7a81\u53d8\u5e8f\u5217 (2)\u91ce\u751f\u578b\u548c\u7a81\u53d8\u578b\u8868\u4f4d\u5e8f\u5217\u4e4b\u95f4\u5b58\u5728\u6f5c\u5728\u7684T\u7ec6\u80de\u53d7\u4f53(TCR)\u4ea4\u53c9\u53cd\u5e94(\u5982\u679c\u4e24\u8005\u90fd\u6709\u7a81\u53d8\u8868\u4f4d\uff0c\u5219\u91ce\u751f\u578b\u548c\u7a81\u53d8\u578b\u8868\u4f4d\u4f1a\u76f4\u63a5\u88ab\u5904\u7406\u5e76\u5448\u9012\u7ed9T\u7ec6\u80de)\u3002\u662f\u5426\u5df2\u7ecf\u5b58\u5728\u53ef\u4ee5\u8bc6\u522b\u91ce\u751f\u578b\u8868\u4f4d\u7684\u7ec6\u80de\u548c\u5728\u6076\u6027\u8f6c\u5316\u540e\u8bc6\u522b\u7a81\u53d8\u9776\u70b9\u7684T\u7ec6\u80de\u7fa4\u4f53\u662f\u5426\u5df2\u7ecf\u6269\u5927\uff0c\u8fd9\u4e24\u4e2a\u95ee\u9898\u5728\u751f\u7269\u5b66\u4e0a\u662f\u76f8\u5173\u7684\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u60c5\u51b5\u53ef\u80fd\u5bfc\u81f4\u4e0d\u540c\u7684TCR\u89e6\u53d1\uff0c\u5e76\u968f\u540e\u5bfc\u81f4\u4e0d\u540c\u7684T\u7ec6\u80de\u6548\u5e94\u5668\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u591a\u80bd\u9776\u6807\u5185\u7684\u7a81\u53d8\u53ef\u4ee5\u8bf1\u5bfcTCR\/CD3\u590d\u5408\u7269\u7684\u5dee\u5f02\u78f7\u9178\u5316\uff0c\u5e76\u5177\u6709\u4e0d\u540c\u7684\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u914d\u7f6e\u3002\u56e0\u6b64\uff0c\u5982\u679c\u91ce\u751f\u578b\u591a\u80bd\u4e5f\u80fd\u88ab\u8bc6\u522b\uff0c\u7a81\u53d8\u53ef\u80fd\u5c31\u4f1a\u56e0\u4e3a\u914d\u4f53\u6ca1\u6709\u88ab\u5904\u7406\u548c\u5448\u9012\uff0c\u800c\u5bfc\u81f4T\u7ec6\u80de\u8bc6\u522b\u529f\u80fd\u4e27\u5931\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u4e5f\u53ef\u80fd\u51fa\u73b0T\u7ec6\u80de\u914d\u4f53\u53ef\u4ee5\u88ab\u5f88\u597d\u5730\u5904\u7406\u548c\u5448\u9012\uff0c\u4f46T\u7ec6\u80de\u4fe1\u53f7\u53ef\u80fd\u7531\u4e8e\u7ec6\u80de\u65e0\u80fd\u800c\u88ab\u6e05\u9664\u7684\u73b0\u8c61\u3002\u90e8\u5206\u6fc0\u52a8\u5242\uff0c\u901a\u8fc7\u8bf1\u5bfc\u5355\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\uff0c\u5373\u4f7f\u5728\u91ce\u751f\u578b\u591a\u80bd\u4e0e\u8868\u4f4d\u7684\u76f8\u4f3c\u5242\u91cf\u8303\u56f4\u5185\uff0c\u4ecd\u7136\u80fd\u591f\u523a\u6fc0\u9488\u5bf9\u91ce\u751f\u578b\u591a\u80bd\u7684T\u7ec6\u80de\u53cd\u5e94\uff1a\u5f53\u5e26\u6709\u91ce\u751f\u578bTCR\u914d\u4f53\u7684T\u7ec6\u80de\u4e0e\u589e\u6b96\u3001\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u548c\u7ec6\u80de\u6bd2\u6027\u53cd\u5e94\u65f6\uff0c\u591a\u80bd\u53d8\u4f53\u53ef\u4ee5\u5728\u6ca1\u6709T\u7ec6\u80de\u589e\u6b96\u7684\u60c5\u51b5\u4e0b\u8bf1\u5bfc\u7ec6\u80de\u6bd2\u6027\u548c\u6216\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7c7b\u4f3c\u7684\u89c2\u5bdf\u7ed3\u679c\u53ef\u80fd\u9002\u7528\u4e8e\u9488\u5bf9\u7a81\u53d8\u8868\u4f4d\u7684TCR\uff0c\u8be5\u8868\u4f4d\u4f1a\u4e0e\u5b9a\u6027\u548c\u5b9a\u91cf\u4e0d\u540c\u7684T\u7ec6\u80de\u53cd\u5e94\u6a21\u5f0f\u53d1\u751f\u53cd\u5e94\u3002\u5355\u4e00\u6c28\u57fa\u9178\u4ea4\u6362\u4e5f\u53ef\u80fd\u4f7fT\u7ec6\u80de\u514b\u9686\u4ea7\u751fTh1\u7ec6\u80de\u56e0\u5b50\u8f6c\u53d8\u4e3a\u4ea7\u751fTh2\u7ec6\u80de\u56e0\u5b50\uff0c\u6216\u8005\u5bfc\u81f4T\u7ec6\u80de\u514b\u9686\u505c\u6b62\u4ea7\u751f\u7ec6\u80de\u56e0\u5b50\uff0c\u4f46\u5982\u75c5\u6bd2\u75c5\u539f\u4f53\u6240\u663e\u793a\u7684\u90a3\u6837\uff0cT\u7ec6\u80de\u4ecd\u5177\u6709\u5f3a\u70c8\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u53cd\u5e94\u3002\u9776\u70b9\u7684\u7a81\u53d8\u4e0e\u4e0d\u540c\u7684\u4fe1\u53f7\u4e8b\u4ef6\u76f8\u5173\uff0c\u4e5f\u53ef\u80fd\u5728T\u7ec6\u80de\u5e94\u5bf9\u91ce\u751f\u578b\u548c\u7a81\u53d8\u9776\u70b9\u65f6\u7684\u5206\u5316\u72b6\u6001\u7684\u8c03\u8282\u8d77\u5173\u952e\u4f5c\u7528\uff0c\u8fd9\u4e00\u70b9\u5728\u80f8\u817a\u7ec6\u80de\u5206\u5316\u548c\u6210\u719f\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u6709\u8bf4\u660e\u3002TCR\u7684\u4e0d\u540c\u89e6\u53d1\u4e0eT\u7ec6\u80de\u7684\u6210\u719f\u548c\u5206\u5316\u6709\u5173\uff0c\u800cT\u7ec6\u80de\u7684\u6210\u719f\u548c\u5206\u5316\u8d28\u91cf\u5bf9\u4e8e\u957f\u671f\u514d\u75ab\u8bb0\u5fc6\u3001\u63a5\u89e6(\u80bf\u7624)\u7ec4\u7ec7\u4ee5\u53caT\u7ec6\u80de\u6cbb\u7597\u7684\u4e34\u5e8a\u7597\u6548\u90fd\u662f\u5341\u5206\u91cd\u8981\u7684\u3002<\/p>\n

\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\uff0c\u9488\u5bf9TAA\uff08\u4e00\u79cd\u6709\u673a\u5316\u5408\u7269\uff09\u7684\u514d\u75ab\u7ec6\u80de\u4f1a\u88ab\u52a8\u8f6c\u79fb\uff0c\u540c\u65f6\u53d1\u73b0T\u7ec6\u80de\u4ea7\u7269\u7684\u8f6c\u79fb\u4f1a\u5bfc\u81f4\u4e2d\u592e\u8bb0\u5fc6T\u7ec6\u80de\u7684\u4ea7\u751f\u3002\u63a7\u5236T\u7ec6\u80de\u8bb0\u5fc6\u7684\u751f\u5316\u4fe1\u53f7\u4e0d\u4ec5\u4f9d\u8d56\u4e8e\u7ec6\u80de\u56e0\u5b50\u73af\u5883\uff0c\u8fd8\u4f9d\u8d56\u4e8eTCR-CD8\u94fe\u590d\u5408\u4f53\u4f20\u9012\u7684\u4fe1\u53f7\u5f3a\u5ea6\u3002\u5305\u62ecT\u7ec6\u80de\u8bb0\u5fc6\u5728\u5185\u7684T\u7ec6\u80de\u53cd\u5e94\u7684\u8d28\u91cf\u548c\u6570\u91cf\u7531\u03b6\u80bd-TCR\u76f8\u4e92\u4f5c\u7528\u7684\u5f3a\u5ea6\u663e\u8457\u51b3\u5b9a\uff0c\u8fd9\u4e00\u73b0\u8c61\u53ef\u80fd\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u4e0eCD8+<\/sup>T\u7ec6\u80de\u6709\u5173\u3002\u73b0\u5728\u5df2\u7ecf\u63d0\u51fa\u4e86\u4e00\u4e2a\u964d\u4f4e\u7535\u4f4d\u6a21\u578b\uff0c\u7528\u4e8e\u6d4b\u91cf\u76ee\u6807\u8868\u4f4d\u4f20\u9012\u7ed9\u76f8\u5e94TCR\u7684\u4fe1\u53f7\u5f3a\u5ea6\uff0c\u8be5TCR\u51b3\u5b9aT\u7ec6\u80de\u662f\u5426\u6709\u53ef\u80fd\u8fdb\u5165T\u7ec6\u80de\u5b58\u50a8\u6c60\u3002\u8fd9\u4e2a\u201c\u4fe1\u53f7\u5f3a\u5ea6\u201d\u6a21\u578b\u9700\u8981\u8003\u8651T\u7ec6\u80de\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u4e0eT\u7ec6\u80de\u8fdb\u5165\u8bb0\u5fc6T\u7ec6\u80de\u6c60\u7684\u591a\u6837\u6027\u76f8\u5173\u7684\u4fc3\u708e\u4fe1\u53f7\u3002\u901a\u5e38\uff0c\u8f83\u5f31\u7684TCR\u4fe1\u53f7\u5c31\u8db3\u4ee5\u5c06T\u5355\u5143\u79fb\u52a8\u5230\u5b58\u50a8\u5668T\u5355\u5143\u7f16\u7a0b\u4e2d\u3002TCR\u4fe1\u53f7\u7684\u957f\u5ea6(\u5373\u7f29\u77edTCR\u523a\u6fc0)\u4e5f\u5c06\u51b3\u5b9aT\u7ec6\u80de\u662f\u5426\u8fdb\u5165\u8bb0\u5fc6T\u7ec6\u80de\u6c60\uff0c\u8fd9\u4e24\u79cd\u51b3\u5b9a\u65b9\u5f0f\u662f\u4e0d\u76f8\u4e92\u6392\u65a5\u7684\u3002\u5e76\u4e14\u89c2\u5bdf\u5230\u7531TCR\u4f9d\u8d56\u7684NFKB\u4fe1\u53f7\u4ecb\u5bfc\u7684\u591a\u80bd\u4e2d\u7684\u70b9\u7a81\u53d8\u5f71\u54cd\u4e86\u4e0eTCR\u7684\u63a5\u89e6\uff0c\u8fd9\u4e5f\u635f\u5bb3\u4e86CD8+<\/sup>T\u7ec6\u80de\u7684\u8bb0\u5fc6\u53d1\u80b2\u3002\u8fd9\u53ef\u80fd\u90e8\u5206\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u9488\u5bf9\u76f8\u540c(\u7a81\u53d8)\u80bf\u7624\u8868\u4f4d\u7684T\u7ec6\u80de\u514b\u9686\u5b58\u5728\u5f02\u8d28\u5206\u5316\u72b6\u6001(\u89c1Fig.4.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 4.2<\/span> \u4e0d\u540c\u7684T\u7ec6\u80de\u514b\u9686(A\uff1aVB5.1\uff0cB-D\uff1aVB9)\u8bc6\u522b\u81ea\u4f53\u80f0\u817a\u764c\u7ec6\u80de\u4e0a\u81ea\u7136\u52a0\u5de5\u548c\u5448\u73b0\u7684(\u7a81\u53d8)\u9776\u70b9\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u80bf\u7624\u5bfc\u5411\u7684T\u7ec6\u80de\u514b\u9686\u8868\u8fbe\u4e0d\u540c\u7684T\u7ec6\u80de\u5f52\u5de2\u548c\u5206\u5316\u6807\u5fd7\u7269\uff0c\u7531CD45RA\u548cCCR7\u7684\u8868\u8fbe\u5b9a\u4e49\uff0c\u5373CD45RA+CCR7+T\u7ec6\u80de\u662f\u524d\u4f53T\u7ec6\u80de\uff0cCD45RA-CCR7+\u4e2d\u592e\u8bb0\u5fc6T\u7ec6\u80de\uff0cCD45RA-CCR7-T\u7ec6\u80de\u8bb0\u5fc6\u6548\u5e94T\u7ec6\u80de\u548cCD45RA+CCR7-T\u7ec6\u80de\u4ee3\u8868\u7ec8\u672b\u5206\u5316\u6548\u5e94T\u7ec6\u80de\u3002\u5176\u4e2d\uff0c\u5927\u591a\u6570\u6765\u81ea\u514b\u9686B\u7684\u7ec6\u80de\u4f4d\u4e8e\u4e2d\u592e\u8bb0\u5fc6T\u7ec6\u80de\u4e9a\u7fa4\u4e2d\uff0c\u8be5\u4e9a\u7fa4\u5df2\u88ab\u8bc1\u660e\u4e0e\u764c\u75c7\u7ec6\u80de\u6cbb\u7597\u4e2d\u589e\u5f3a\u7684\u53cd\u5e94\u6027\u6709\u5173\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | Martin Rao, Liu Zhenjiang, Qingda Meng, Georges Sinclair,<\/span>
<\/p>\n

        Ernest Dodoo, and Markus Maeurer<\/span><\/p>\n

\u7ffb\u8bd1 | \u90d1\u68a6\u6021 \u5f90\u66fc\u65af <\/span><\/p>\n

\u7f16\u8f91\u6392\u7248 | \u949f\u96ea\u83b9<\/span><\/span><\/p>\n

\u521d\u5ba1 | \u5b8b\u4e50 \u9648\u79cb\u8c37<\/span><\/p>\n

\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


<\/section>\n

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\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c24\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c23\u7ae0\uff1a\u708e\u75c7\u4e0e\u514d\u75ab<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c22\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u529f\u80fd<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c21\u7ae0\uff1a\u541e\u566c\u7ec6\u80de<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c20\u7ae0\uff1a\u56fa\u6709\u514d\u75ab\u7684\u9632\u5fa1\u4f5c\u7528<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c19\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u751f\u7406\u529f\u80fd\u7b80\u8ff0<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c17\u7ae0\uff1a\u514d\u75ab\u8bb0\u5fc6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7a33\u6001<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c16\u7ae0\uff1aT\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
<\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c3\u7ae0\uff1aCD8+ T\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u548c\u5316\u7597\u4e2d\u7684\u4f5c\u7528\uff08\u4e0b\uff09<\/span><\/a>
<\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c3\u7ae0\uff1aCD8+ T\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u548c\u5316\u7597\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09<\/span><\/a>
<\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0b\uff09<\/span><\/a>
<\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0a\uff09<\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c1\u7ae0\uff1a\u80bf\u7624\u514d\u75ab\u7b80\u53f2<\/a><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/p>\n

TCGA\u514d\u75ab\u6d78\u6da6\u8bc4\u4ef7\u6570\u636e\u5e93<\/a>
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ggplot2|\u8be6\u89e3\u516b\u5927\u57fa\u672c\u7ed8\u56fe\u8981\u7d20<\/a>
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Python\u96c6\u6210\u5f00\u53d1\u73af\u5883PyCharm\u7684\u5b89\u88c5\u4e0e\u6fc0\u6d3b<\/a>
<\/p>\n

Python\u53d1\u884c\u7248Anaconda\u7684\u5b89\u88c5\u4e0e\u4f7f\u7528<\/a><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span>
<\/p>\n

Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

QPCR\u5b9e\u9a8c\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a>
<\/p>\n

\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a>
<\/p>\n

HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a>
<\/p>\n

PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
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Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
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PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
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\u4e2d\u533b\u4e2d\u836f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

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