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4.4 \u65b0\u8868\u4f4d\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u7684\u4e34\u5e8a\u610f\u4e49<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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4.5 \u5229\u7528\u57fa\u7840\u514d\u75ab\u5b66\u6539\u8fdb\u4e34\u5e8a\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u80a0\u9053\u5171\u751f\u7ec6\u83cc\u5bf9\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u514d\u75ab\u53cd\u5e94\u7684\u5f62\u6210(\u548c\u91cd\u5851)\u7684\u5f71\u54cd\u4e00\u76f4\u662f\u5f53\u524d\u514d\u75ab\u5b66\u7814\u7a76\u7684\u6838\u5fc3\u3002\u6700\u8fd1\u7814\u7a76\u8868\u660e\uff0c\u5728\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u6297CTLA-4\u6cbb\u7597\u8bf1\u5bfcT\u7ec6\u80de\u5bf9\u90e8\u5206\u201c\u514d\u75ab\u539f\u6027\u201d\u80a0\u9053\u7ec6\u83cc(\u5982Thetaiotaomicron\u548cB.Fragilis)\u4ea7\u751f\u514d\u75ab\u5e94\u7b54\uff0c\u6b64\u8fc7\u7a0b\u4e0e\u4e34\u5e8a\u7597\u6548\u76f8\u5173\u3002\u5728\u5bf9\u80bf\u7624\u9ad8\u5ea6\u654f\u611f\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5f15\u5165\u53cc\u6b67\u6746\u83cc\uff0c\u663e\u8457\u6539\u5584\u4e86\u5bf9\u80bf\u7624\u8d1f\u8377\u7684\u7ec6\u80de\u6bd2\u6027\u6dcb\u5df4\u7ec6\u80de\u4f9d\u8d56\u6027\u7684\u63a7\u5236\u3002\u53cc\u6b67\u6746\u83cc\u63a5\u79cd\u7ed3\u5408\u6297PD-L1\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\uff0c\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4e86\u8fd9\u4e9b\u52a8\u7269\u7684\u80bf\u7624\u63a7\u5236\uff0c\u4ece\u800c\u5f3a\u5316\u4e86\u80a0\u9053\u5fae\u751f\u7269\u533a\u7cfb\u5728\u51b3\u5b9a\u6297\u764c\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u7528\u514d\u75ab\u963b\u65ad\u7597\u6cd5\u6216T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u8865\u5145\u80a0\u9053\u7ec6\u83cc\u4e2d\u7684\u751f\u7269\u6d3b\u6027\u7269\u8d28\u53ef\u80fd\u4f1a\u6f5c\u5728\u5730\u6539\u5584\u665a\u671f\u764c\u75c7\u60a3\u8005\u7684\u65b0\u6297\u539f\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9776\u5411\u6fc0\u6d3bCD8+<\/sup>T\u7ec6\u80de\u8102\u80aa\u9178\u6c27\u5316(FAO)\uff0c\u4fc3\u8fdb\u7ec6\u80de\u8bb0\u5fc6\u7ef4\u6301\u7684\u5c0f\u5206\u5b50\u548c\u7ec6\u80de\u56e0\u5b50\u53ef\u4f5c\u4e3a\u764c\u75c7\u548c\u611f\u67d3\u6027\u75be\u75c5\u4e3b\u6d41\u6cbb\u7597\u65b9\u6848\u7684\u8f85\u52a9\u624b\u6bb5\u3002\u4f8b\u5982\uff0c\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\u4e8c\u7532\u53cc\u80cd\u6fc0\u6d3b\u4e865′-\u817a\u82f7\u4e00\u78f7\u9178\u6d3b\u5316\u86cb\u767d\u6fc0\u9176(AMPK)\uff0c\u5e76\u6539\u5584\u4e86FAO<\/span>\u5728\u8bb0\u5fc6CD8+<\/sup>TIL\u4e2d\u7684\u4f5c\u7528\uff0c\u5728\u5316\u5b66\u8bf1\u5bfc\u7684\u76ae\u80a4\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\u8bc1\u5b9e\u6709\u6548\u3002IL-15\u901a\u8fc7\u4e0a\u8c03\u7ebf\u7c92\u4f53\u751f\u7269\u5408\u6210\u548c\u8bf1\u5bfc\u8089\u78b1\u68d5\u6988\u9170\u8f6c\u79fb\u9176\u7684\u8868\u8fbe\u6765\u4fc3\u8fdb\u8102\u8d28\u4ee3\u8c22\uff0c\u8089\u78b1\u68d5\u6988\u9170\u8f6c\u79fb\u9176\u662f\u7ebf\u7c92\u4f53\u03b2-\u6c27\u5316\u7684\u5173\u952e\u9176\u3002\u8fd9\u4e00\u8fc7\u7a0b\u5df2\u88ab\u8bc1\u660e\u5728\u5c0f\u9f20\u7684\u8bb0\u5fc6CD8+<\/sup>T\u7ec6\u80de\u4e2d\u4e0a\u8c03\uff0c\u5e76\u63d0\u9ad8\u4e86\u5b83\u4eec\u7684\u5b58\u6d3b\u7387\u3002\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\uff0cIL-15\u5df2\u88ab\u8bc4\u4ef7\u4e3a\u4e00\u79cd\u8f85\u52a9\u4f50\u5242\uff0c\u5bf9TIL\u7684\u589e\u6b96\u548c\u589e\u5f3a\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u6709\u663e\u8457\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T\u7ec6\u80de\u7684\u514d\u75ab\u8010\u53d7\u6027\u5bf9\u4e8e\u9884\u9632\u660e\u663e\u7684\u75c5\u7406\u72b6\u6001\u662f\u5fc5\u8981\u7684\uff0c\u800cTreg\u6570\u91cf\u7684\u589e\u52a0\u5bf9\u57fa\u4e8e\u7ec6\u80de\u7684\u514d\u75ab\u7597\u6cd5\u7684\u6210\u529f\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u867d\u7136\u8f93\u6ce8\u95f4\u5145\u8d28\u57fa\u8d28\u7ec6\u80de\u6765\u4e0b\u8c03\u4e25\u91cd\u708e\u75c7\u540e\u4f1a\u4ea7\u751f\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u5e76\u6fc0\u6d3bTreg\uff0c\u4f46\u56de\u8f93\u5230\u80bf\u7624\u60a3\u8005\u4f53\u5185\u7684T\u7ec6\u80de\u4ea7\u54c1\u53ea\u5141\u8bb8\u542b\u6709\u6700\u4f4e\u9650\u5ea6\u7684Treg\u4e9a\u7fa4\uff0c\u4ee5\u4f18\u5316\u764c\u75c7\u7279\u5f02\u6027T\u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u6b64\u5916\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6162\u6027\u708e\u75c7\u65f6\u4ea7\u751f\u7684IL-17\u53ef\u4ee5\u8bf1\u5bfc\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u7684\u4ea7\u751f\uff0c\u6291\u5236CD8+<\/sup>T\u7ec6\u80de\u7684\u53cd\u5e94\u3002TAA\u4e5f\u53ef\u4ee5\u523a\u6fc0Tregs\uff0c\u5373\u7ed9\u4e88NY-ESO-1\/ISCOMATRIXTM<\/sup>\u6cbb\u7597\u6027\u75ab\u82d7\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684NY-ESO-1157-170<\/sub>\u7279\u5f02\u6027Treg\u53cd\u5e94\uff1bNY-ESO-1119-143<\/sub>\u548cTRIG-334-48<\/sub>(\u6765\u6e90\u4e8e\u53e6\u4e00\u79cd\u764c\u75c7\u777e\u4e38\u6297\u539f\uff0c\u764c\u75c7\/\u777e\u4e38\u6297\u539f\u5bb6\u65cf24)\u53ef\u4ee5\u8bf1\u5bfc\u9ed1\u8272\u7d20\u7624\u60a3\u8005Th1\u7ec6\u80de\u548cFoxP3+ Tregs\u7684\u589e\u6b96\uff0c\u4ece\u800c\u4fc3\u8fdb\u514d\u75ab\u5e94\u7b54\u3002\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u6765\u66f4\u597d\u5730\u7406\u89e3\u67d0\u4e9b\u7a81\u53d8\u662f\u5426\u4ee3\u8868\u9488\u5bf9\u764c\u75c7\u7a81\u53d8\u7684Tregs\u7684\u540d\u4e49\u4e0a\u7684\u8868\u4f4d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
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\u57fa\u7840\u7814\u7a76\u4ea7\u751f\u7684\u65b0\u4fe1\u606f\u9700\u8981\u8003\u8651\u7eb3\u5165T\u7ec6\u80de\u4ea7\u54c1\u7684\u4e34\u5e8a\u524d\u8bc4\u4f30\u3002\u4f8b\u5982\uff0cCNC Homolog 2(BACH2)\u662f\u4e00\u79cd\u8f6c\u5f55\u56e0\u5b50\uff0c\u5b83\u53ef\u4fc3\u8fdb\u5bbf\u4e3b\u4e2d\u8c03\u8282\u6027\u548c\u4e2d\u592e\u8bb0\u5fc6\u6027T\u7ec6\u80de\u7684\u751f\u6210\u548c\u7ef4\u62a4\uff0c\u540c\u65f6\u6291\u5236\u514d\u75ab\u6548\u5e94\u5668\u673a\u5236\uff0c\u56e0\u6b64BACH2\u4ee5\u53caBTB\u7ed3\u6784\u57df\u53ef\u80fd\u662f\u8868\u5f81T\u7ec6\u80de\u7fa4\u4f53\u7684\u6709\u7528\u5de5\u5177\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u7fa4\u4f53\u53ef\u80fd\u4f1a\u6301\u7eed\u5b58\u5728\u4e8e\u60a3\u8005\u4f53\u5185\uff0c\u4ee5\u5bf9\u6297\u8f6c\u5316\u7684\u7ec6\u80de\u3002\u7f3a\u4e4fBACH2\u7684\u5c0f\u9f20\u80fd\u591f\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4ea7\u751f\u5f3a\u70c8\u7684T\u7ec6\u80de\u53cd\u5e94(\u4ee5CD4+<\/sup>\u548cCD8+ <\/sup>T\u7ec6\u80de\u589e\u6b96\u548c\u5e72\u6270\u7d20-\u03b3\u4ea7\u751f\u4e3a\u6807\u5fd7)\uff0c\u4f34\u968f\u7740FoxP3+\u8c03\u8282\u6027T\u7ec6\u80de\u6570\u91cf\u7684\u51cf\u5c11\uff0c\u8fd9\u968f\u540e\u5c06\u6539\u5584\u5bf9\u80bf\u7624\u7684\u63a7\u5236\u3002BACH2\u7f3a\u4e4f\u8fd8\u589e\u52a0\u4e86\u9897\u7c92\u9176\u548c\u7a7f\u5b54\u7d20\u7b49\u7ec6\u80de\u6bd2\u5206\u5b50\u7684\u57fa\u56e0\u8f6c\u5f55\u3002\u4ece\u7ffb\u8bd1\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u4e00\u53d1\u73b0\u5bf9\u589e\u5f3a\u9776\u5411\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u4e2dT\u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u6548\u5e94\u6709\u76f4\u63a5\u610f\u4e49\u3002\u8c03\u8282\u75c5\u53d8\u7ec4\u7ec7\u4e2d\u65b0\u6297\u539f\u53cd\u5e94\u6027T\u7ec6\u80de(\u5373TIL)\u548c\u5916\u5468\u8840T\u7ec6\u80de\u4e2dBACH2\u7684\u8868\u8fbe\uff0c\u53ef\u4ee5\u63d0\u9ad8\u514d\u75ab\u7ec6\u80de\u7684\u8d28\u91cf\u548c\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5229\u7528\u65b0\u7684\u6280\u672f\u5e73\u53f0\u5728\u75be\u75c5\u7ec4\u7ec7\u4e2d\u7b5b\u9009\u7279\u5f02\u6027TCR\uff0c\u5373\u6df1\u5ea6(TCR)\u6d4b\u5e8f\u3001\u80bd\u5fae\u9635\u5217\u3001\u7ec6\u80de\u5fae\u9635\u5217\u548cTCR\u8868\u4f4d\u5bf9\u63a5\u7814\u7a76\uff0c\u5bf9\u4e8e\u6211\u4eec\u76ee\u524d\u5bf9\u75be\u75c5\u673a\u5236\u548c\u514d\u75ab\u52a8\u529b\u5b66\u7684\u7814\u7a76\u6709\u5f88\u5927\u8d21\u732e\u3002\u8fd9\u53ef\u80fd\u4f7f\u6211\u4eec\u80fd\u591f\u66f4\u8be6\u7ec6\u5730\u63cf\u8ff0\u5bf9\u6297\u764c\u7684\u957f\u671f\u514d\u75ab\u4fdd\u62a4\u81f3\u5173\u91cd\u8981\u7684\u514d\u75ab\u8c31\u7cfb\u3002\u5c06\u6570\u5b66\u77e5\u8bc6\u548c\u5bf9\u80bf\u7624\u52a8\u529b\u5b66\u4ee5\u53ca\u80bf\u7624\u8fdb\u5c55\u7b97\u6cd5\u7684\u751f\u7269\u5b66\u7406\u89e3\u7ed3\u5408\u8d77\u6765\uff0c\u5c06\u5bf9\u8fd9\u4e00\u9886\u57df\u5927\u6709\u88e8\u76ca\u3002\u6b64\u5916\uff0c\u4f7f\u7528\u8fd9\u4e9b\u6280\u672f\u5bf9\u5065\u5eb7\u4e2a\u4f53\u548c\u60a3\u8005\u7684\u4e0d\u540c\u89e3\u5256\u90e8\u4f4d\u7684\u4e34\u5e8a\u6837\u672c\u8fdb\u884c\u6bd4\u8f83\u7814\u7a76\uff0c\u4e3a\u4e0b\u4e00\u4ee3\u751f\u7269\u7597\u6cd5\u7684\u5f00\u53d1\u63d0\u4f9b\u65b0\u7684\u4fe1\u606f\u3002<\/p>\n

TIL\u548cPBMC\u4e2dTCR\u7684\u5dee\u5f02\uff0c\u4ee5\u53ca\u764c\u75c7\u60a3\u8005\u7684\u7a81\u53d8\u8d1f\u8377\u4e0e\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6210\u6548\u6709\u5173\u3002\u5728\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u5f88\u660e\u663e\uff0c\u4ed6\u4eec\u7684\u7a81\u53d8\u8d1f\u8377\u6700\u9ad8\uff0c\u5bf9\u6297PD-1\u548c\/\u6216\u6297CTLA-4\u6cbb\u7597\u53cd\u5e94\u826f\u597d\u3002\u201c\u6316\u6398\u201d\u9488\u5bf9\u764c\u75c7\u7a81\u53d8\u7684\u751f\u7269\u5b66\u548c\u4e34\u5e8a\u76f8\u5173\u7684TCR\u53ef\u80fd\u5bfc\u81f4\u901a\u8fc7\u514b\u9686\u548c\u8f6c\u79fb\u7279\u5b9a\u7684TCR\u5230PBMC\u6765\u4ea7\u751f\u7528\u4e8e\u6cbb\u7597\u7684T\u7ec6\u80de\u4ea7\u54c1\u3002<\/p>\n

\u8fd9\u4e9b\u4f8b\u5b50\u7a81\u663e\u4e86\u4e00\u4e2a\u5df2\u7ecf\u8ba8\u8bba\u4e86\u51e0\u5341\u5e74\u7684\u8bdd\u9898\u7684\u91cd\u8981\u6027\uff0c\u4f8b\u5982\u5728\u9488\u5bf9HIV\u7684\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u9886\u57df\uff1a\u9488\u5bf9\u7a81\u53d8\u8868\u4f4d\u7684\u5b9a\u5236\u514d\u75ab\u53cd\u5e94\u5e94\u8be5\u7ed9\u4e88\u591a\u5c11\u5173\u6ce8\u548c\u63d0\u4f9b\u591a\u5c11\u591a\u6837\u6027\uff1f\u8003\u8651\u5230(1)\u539f\u53d1\u80bf\u7624\u7684\u7a81\u53d8\u4e0e\u590d\u53d1\u7684\u76f8\u4f3c\u6027\uff1b(2)\u539f\u53d1\u80bf\u7624\u548c\u8fdc\u5904\u8f6c\u79fb\u6240\u8868\u73b0\u51fa\u7684\u7a81\u53d8\u591a\u6837\u6027\uff1b(3)\u57fa\u56e0\u8868\u8fbe\u7684\u201c\u5c40\u90e8\u201d\u5370\u8bb0(\u5e76\u975e\u6240\u6709\u7f16\u7801DNA\u7684\u57fa\u56e0\u90fd\u53ef\u80fd\u5b8c\u5168\u6216\u5728\u67d0\u4e9b\u70b9\u88ab\u7ffb\u8bd1\u6210RNA\uff0c\u7136\u540e\u518d\u8f6c\u5316\u6210\u86cb\u767d\u8d28)\uff0c\u4e0e\u7ec4\u7ec7\u73af\u5883(\u5982\u80ba\u548c\u809d\u8f6c\u79fb)\u6709\u5173\u3002<\/p>\n

\u8fd9\u4e9b\u95ee\u9898\u5c06\u4ee3\u8868\u4e34\u5e8a\u76f8\u5173\u7814\u7a76\u7684\u95ee\u9898\uff0c\u5e76\u5bf9\u751f\u7269\u5b66\u548c\u4e34\u5e8a\u76f8\u5173\u7814\u7a76\u7684\u8bbe\u8ba1\u4ea7\u751f\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u5982\u679cTIL\u5728\u4e34\u5e8a\u68c0\u6d4b\u5230\u590d\u53d1\u65f6\u53ef\u4ee5\u7acb\u5373\u4ece\u539f\u53d1\u80bf\u7624\u83b7\u5f97\uff0c\u90a3\u4e48\u5e94\u8be5\u8003\u8651\u539f\u53d1\u80bf\u7624\u4e0e\u76f8\u5e94\u590d\u53d1\u6076\u6027\u80bf\u7624\u7684\u76f8\u4f3c\u6027\u548c\u5dee\u5f02\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\n
<\/section>\n<\/section>\n
\n
\n
\n

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\n
\n

\u8bc6\u522b\u548c\u9a8c\u8bc1\u4e34\u5e8a\u4e0a\u548c\u751f\u7269\u5b66\u4e0a\u76f8\u5173\u7684\u65b0\u8868\u4f4d\u4ecd\u7136\u662f\u4e00\u4e2a\u6311\u6218\uff0c\u5373\u8868\u4f4d\u662f\u5426\u4ee5\u4ee3\u8868\u6027\u7684\u65b9\u5f0f\u8868\u8fbe\uff0c\u5b83\u4eec\u662f\u5426\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\u88ab\u52a0\u5de5\u548c\u5448\u9012\uff0c\u4ee5\u53ca\u662f\u5426\u6709\u201c\u5408\u9002\u7684\u201dTCR\u8c31\u7cfb\u53ef\u7528\u5e76\u80fd\u591f\u5bf9\u5176\u4ea7\u751f\u53cd\u5e94-\u5bfc\u81f4\u514d\u75ab\u6548\u5e94\u529f\u80fd\uff0c\u4ece\u800c\u6700\u5927\u53ef\u80fd\u5730\u4fc3\u8fdb\u5f3a\u5927\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u4e00\u79cd\u53ef\u80fd\u7684\u65b9\u6cd5\u662f\u6839\u636e\u764c\u75c7\u60a3\u8005\u7684\u5168\u57fa\u56e0\u7ec4\u5e8f\u5217\u8bbe\u8ba1\u548c\u4ea7\u751f\u6f5c\u5728\u7684\u65b0\u8868\u4f4d\u3002\u4e00\u65e6\u8fd9\u4e9b\u65b0\u8868\u4f4d\u88ab\u5316\u5b66\u5408\u6210\uff0c\u5b83\u4eec\u5c31\u53ef\u4ee5\u88ab\u63d0\u4ea4\u7ed9T\u7ec6\u80de\u57f9\u517b\u7684\u5927\u89c4\u6a21\u4f53\u5916\u7b5b\u9009\uff0c\u4ee5\u4fbf\u4ed4\u7ec6\u6311\u9009\u9ad8\u8d28\u91cf\u7684\u7a81\u53d8\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u53ef\u4ee5\u6269\u589e\u5e76\u91cd\u65b0\u6ce8\u5165\u60a3\u8005\u4f53\u5185\u3002\u4ee5\u975e\u4e92\u65a5\u7684\u65b9\u5f0f\uff0c\u53ef\u4ee5\u514b\u9686\u4ec5\u9488\u5bf9\u7a81\u53d8\u578bTAA\u800c\u4e0d\u662f\u91ce\u751f\u578b\u80bd\u7684\u5e8f\u5217\u7684TCR\uff0c\u5e76\u968f\u540e\u5c06\u5176\u8f6c\u79fb\u5230\u53d7\u4f53\u9776\u7ec6\u80de(T\u7ec6\u80de)\u4e2d\uff0c\u7528\u4e8e\u764c\u75c7\u60a3\u8005\u7684\u4e3b\u52a8\u7ec6\u80de\u6cbb\u7597\u3002<\/p>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

PBMC\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u4e2a\u975e\u5e38\u597d\u7684\u8d77\u70b9\u6765\u7b5b\u9009\u60a3\u8005\u4f53\u5185\u5faa\u73af(\u548c\u518d\u5faa\u73af)\u7684\u65b0\u8868\u4f4d\u7279\u5f02\u6027T\u7ec6\u80de\u7fa4\u4f53\u3002\u7f57\u68ee\u4f2f\u683c\u7814\u7a76\u5c0f\u7ec4\u6307\u51fa\uff0c\u5916\u5468T\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u7a81\u53d8\u8868\u4f4d\/\u65b0\u8868\u4f4d\u7684\u4e8b\u5b9e\u662f\uff0cPD-1+<\/sup>T\u7ec6\u80de\u7fa4\u4f53\u5bcc\u542b\u80bf\u7624\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u8fd9\u66f4\u591a\u5730\u53cd\u6620\u4e86\u63a5\u89e6\u8fc7\u6297\u539f\u7684T\u7ec6\u80de\u7684\u8c31\u7cfb\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u201c\u8017\u5c3d\u201d\u7684T\u7ec6\u80de\u3002\u8fd9\u4e0e\u65e9\u671f\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684TIL\u7814\u7a76\u7ed3\u679c\u76f8\u547c\u5e94\uff1aPD1+<\/sup>TIL\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u7a81\u53d8\u3002\u7136\u800c\uff0c\u80bf\u7624\u75c5\u53d8\u7684\u5f02\u8d28\u6027\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u5305\u62ec\u5bf9\u201c\u7a81\u53d8\u4f53\u591a\u6837\u6027\u201d\u7684\u89e3\u5256\u5b66\u7814\u7a76\uff0c\u4ee5\u53ca\u4ece\u5355\u4e2a\u764c\u75c7\u75c5\u53d8\u4e2d\u53ef\u83b7\u5f97\u7684\u76f8\u5e94\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7684\u591a\u6837\u6027\u3002\u9488\u5bf9\u5171\u6709\u6216\u79c1\u6709\u7a81\u53d8\u7684TCR\u8f6c\u79fb\u7684\u4e00\u4e2a\u8981\u70b9\u662f\uff0c\u5448\u73b0\u764c\u75c7\u8868\u4f4d\u7684HLA\u9650\u5236\u6027\u5143\u4ef6\u56e0\u4e2a\u4f53\u4e0d\u540c\u800c\u4e0d\u540c\u3002\u56e0\u6b64\uff0c\u5e76\u4e0d\u662f\u6240\u6709\u7684\u60a3\u8005\u90fd\u80fd\u4ece\u5355\u4e00\u7684TCR-HLA\u5339\u914d\u7684T\u7ec6\u80de\u4ea7\u54c1\/TCR\u8f6c\u79fb\u4e2d\u53d7\u76ca\uff0c\u800c\u662f\u4e00\u79cd\u66f4\u4e2a\u6027\u5316\u7684\u65b9\u6cd5\uff0c\u8003\u8651\u5230\u65b0\u7684\u8868\u4f4d\u7ed3\u6784\u3001\u76f8\u5e94\u7684TCR\u5e8f\u5217\u4ee5\u53caHLA\u9650\u5236\u5143\u4ef6\u3002\u8fd9\u65b9\u9762\u7684\u4e00\u4e2a\u4f8b\u5b50\u662f\u4e0eEB\u75c5\u6bd2(EBV)\u8bf1\u5bfc\u7684\u708e\u6027T\u7ec6\u80de\u53cd\u5e94\u76f8\u5173\u7684PTLD\u7684\u53d1\u751f\u3002\u5177\u6709HLA-A2\u3001A11\u3001B5\u3001B18\u3001B21\u3001Bw22\u548cB35\u80cc\u666f\u7684\u4e2a\u4f53\u6bd4\u5177\u6709HLA-A03\u6216HLA-DR7(CD4+<\/sup>T\u8f85\u52a9\u7ec6\u80de\u53cd\u5e94)\u9057\u4f20\u80cc\u666f\u7684\u4e2a\u4f53\u5728\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u540e\u53d1\u751fPTLD\u7684\u98ce\u9669\u66f4\u5927\uff0c\u800c\u5177\u6709HLA-A1\u3001B8\u6216DR8\u80cc\u666f\u7684\u4e2a\u4f53\u4f3c\u4e4e\u5bf9PTLD\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002\u5728\u4e59\u578b\u809d\u708e\u75c5\u6bd2(HBV)\u8bf1\u5bfc\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u9776\u5411\u514d\u75ab\u6cbb\u7597\u4e2d\uff0c\u4e5f\u8981\u4ed4\u7ec6\u9009\u62e9\u7279\u5f02\u6027TCR\u548cHLA\u9650\u5236\uff0c\u91cd\u70b9\u662fHBV\u7279\u5f02\u6027\u8868\u4f4d\u548c\u6f5c\u5728\u7684\u65b0\u8868\u4f4d\u3002<\/p>\n

\u8377\u5170\u764c\u75c7\u7814\u7a76\u6240\u7684Ton Schumacher\u7814\u7a76\u5c0f\u7ec4\u6700\u8fd1\u8868\u660e\uff0c\u7531\u4e8e\u80bf\u7624\u60a3\u8005\u81ea\u7136\u4ea7\u751f\u7684\u65b0\u8868\u4f4d\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u53ef\u80fd\u4f1a\u88ab\u6c89\u9ed8\uff0c\u800c\u4e14\u4ece\u5065\u5eb7\u4eba\u7684\u5916\u5468\u8840\u6db2\u4e2d\u5206\u79bb\u51fa\u7684T\u7ec6\u80de\u53ef\u80fd\u542b\u6709\u8bc6\u522b\u65b0\u8868\u4f4d\u7684TCR\uff0c\u540e\u4e00\u79cd\u9009\u62e9\u53ef\u80fd\u4ee3\u8868\u7740\u4ea7\u751f\u6297\u7a81\u53d8\u8868\u4f4d\u53cd\u5e94\u6027T\u7ec6\u80de\u7684\u8d77\u70b9\u3002CTL\u7cfb\u8bc6\u522b5\u79cd\u4e0d\u540c\u7684HLAA2\u9650\u5236\u6027\u65b0\u8868\u4f4d\uff0c\u4ece\u4e0d\u540c\u5065\u5eb7\u4f9b\u8005\u7684PBMC\u4e2d\u5efa\u7acb\uff0c\u5e76\u5bf9\u8868\u8fbe\u540c\u6e90(\u7a81\u53d8)T\u7ec6\u80de\u8868\u4f4d\u7684\u60a3\u8005\u6765\u6e90\u7684\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u682a\u4ea7\u751f\u5e72\u6270\u7d20-\u03b3\u548c\/\u6216CD107a\u3002\u6b64\u5916\uff0c\u8bc6\u522b\u65b0\u8868\u4f4d\u7684T\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u8868\u8fbe\u7684\u8868\u4f4d\u8868\u73b0\u51fa\u5f88\u5f3a\u7684\u80bd-\u03b2\u7ed3\u5408\u52a8\u529b(MHC-class I-HLA2\u5fae\u7403\u86cb\u767d-\u8868\u4f4d\u76f8\u4e92\u4f5c\u7528\u7684\u534a\u8870\u671f)\uff0c\u7136\u540e\u53ef\u4ee5\u514b\u9686\u5e76\u5f02\u6e90\u8868\u8fbe\u4e00\u4e2a\u9488\u5bf9\u7a81\u53d8\u7279\u5f02\u6027T\u7ec6\u80de\u91cf\u8eab\u5b9a\u505a\u7684\u201c\u6539\u8fdb\u7684\u201dTCR\u8c31\u7684\u4eba\u7684T\u7ec6\u80de\u3002\u8fd9\u5df2\u7ecf\u5728\u764c\u75c7\u60a3\u8005\u7684PBMC\u4e2d\u88ab\u8bc1\u660e\uff0c\u4f7f\u7528\u6765\u81eaMHC\u578b\u76f8\u5408\u6350\u8d60\u8005\u7684T\u7ec6\u80de\uff0c\u5728\u4e34\u5e8a\u4e0a\u88ab\u8bc1\u660e\u5728\u611f\u67d3\u6027\u75be\u75c5\u7684\u80cc\u666f\u4e0b\u662f\u53ef\u884c\u7684\uff0c\u5373\u901a\u8fc7\u5728\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u5c06CMV\u7279\u5f02\u6027T\u7ec6\u80de\u4ece\u4e0eHLA I\u7c7b\u9650\u5236\u6027\u7b49\u4f4d\u57fa\u56e0\u76f8\u5339\u914d\u7684\u540c\u79cd\u5f02\u4f53\u6350\u8d60\u8005\u8f6c\u79fb\u5230CMV\u611f\u67d3\u60a3\u8005(\u548c\u65e0\u529f\u80fd\u7684\u514d\u75ab\u7cfb\u7edf)\u3002\u6b64\u5916\uff0c\u4f7f\u7528HLA-I\u7c7b\u5339\u914d\u7684TIL(\u89c1Table 4.2<\/span>)\u4e5f\u4ea7\u751f\u4e86\u7c7b\u4f3c\u7684\u89c2\u5bdf\u7ed3\u679c\uff0c\u8fd9\u4e9bTIL\u88ab\u8bc1\u660e\u5bf9\u6765\u81eaHLA-B*2705\u5339\u914d\u60a3\u8005\u7684\u81ea\u4f53\u80bf\u7624\u7ec6\u80de\u4e0a\u8bc6\u522b\u7684\u7a81\u53d8\u7684\u9776\u8868\u4f4d\u6709\u53cd\u5e94\uff08\u5373\u6ca1\u6709\u91cd\u65b0\u523a\u6fc0\u548c\u6269\u589e\uff09\uff0c\u8fd9\u8868\u660e\uff0c\u5373\u4f7f\u5728TIL\u4e2d\uff0c\u524d\u4f53T\u7ec6\u80de\u4e5f\u5b58\u5728\uff0c\u5728\u66b4\u9732\u4e8e\u201c\u9a71\u52a8\u201d\u7a81\u53d8(\u5373KRAS\u3001Smad4\u3001P53\u6216\u751a\u81f3\u662f\u4e2a\u4f53\u4e4b\u95f4\u5171\u540c\u7684\u7a81\u53d8)\u7684\u8868\u4f4d\u4e4b\u540e\uff0c\u5728TIL\u4e2d\u4e5f\u4f1a\u4ea7\u751f\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 4.2 <\/span>MHC-I\u76f8\u5339\u914d\u7684\u4e0d\u540c\u60a3\u8005\u7684TIL\u7a81\u53d8\u8868\u4f4d\u7684\u5171\u540c\u8bc6\u522b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u505a\u597d\u51c6\u5907\uff1a<\/strong>\u589e\u5f3a\u5e94\u5bf9\u7a81\u53d8\u4f53\u9776\u70b9\u7684TCR\u5e93<\/strong><\/p>\n

\u4f7f\u7528\u6807\u51c6\u6297\u764c\u836f\u7269(\u5373\u5409\u897f\u4ed6\u6ee8\u3001\u5730\u897f\u4ed6\u6ee8\u3001\u987a\u94c2\u548c\u963f\u9709\u7d20)\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u53ef\u4ee5\u4fc3\u8fdb\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u7b49\u6297\u539f\u63d0\u5448\u7ec6\u80de\u7684\u6fc0\u6d3b\uff0c\u5e76\u4fc3\u8fdb\u6297\u539f\u5904\u7406\u3001\u6fc0\u53d1\u4fc3\u708e\u514d\u75ab\u53cd\u5e94\uff0c\u5373\u4ea7\u751fIL-12\u3002\u6b64\u5916\uff0c\u5730\u897f\u4ed6\u6ee8\u7684\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u4e5f\u88ab\u8bc1\u660e\u80fd\u8bf1\u5bfcCD8+ <\/sup>T\u7ec6\u80de\u4ecb\u5bfc\u7684\u5f3a\u5927\u7684\u6297\u764c\u7ec6\u80de\u6bd2\u53cd\u5e94\uff0c\u800c\u4e0e\u5355\u72ec\u5316\u7597\u76f8\u6bd4\uff0c\u5b83\u4e0e\u7ec6\u80de\u56e0\u5b50\u6fc0\u6d3b\u7684\u6740\u4f24\u7ec6\u80de\u4e00\u8d77\u7528\u4e8e\u80f0\u817a\u764c\u60a3\u8005\u53ef\u4ee5\u63d0\u9ad8\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u3002\u8f85\u52a9\u764c\u75c7\u6cbb\u7597\u540e\u7684\u65b0\u6297\u539f\u7279\u5f02\u6027\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u7684\u589e\u52a0\u5c1a\u672a\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u4f46\u53ef\u80fd\u662f\u672a\u6765\u8bc4\u4f30\u7684\u91cd\u70b9\u2014\u2014\u65e8\u5728\u63d0\u9ad8\u60a3\u8005\u7a81\u53d8\u4f53\u5bf9\u5176\u514d\u75ab\u8c31\u7cfb\u7684\u201c\u53ef\u89c1\u6027\u201d\u3002\u6297\u764c\u514d\u75ab\u53cd\u5e94\u53ef\u4ee5\u901a\u8fc7\u201c\u6807\u51c6\u6cbb\u7597\u624b\u6cd5\u201d\u589e\u5f3a\u7684\u4e00\u4e2a\u5f3a\u6709\u529b\u7684\u8bba\u70b9\u662f\uff0c\u5728\u63a5\u53d7\u5168\u8111\u653e\u5c04\u6cbb\u7597(WBRT)\u7684\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\uff0c\u514d\u75ab\u53cd\u5e94\u88ab\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u8fdc\u5904\u75c5\u7076\u7684\u80bf\u7624\u6d88\u9000\u3002\u665a\u671f\u9ed1\u8272\u7d20\u7624\u76f8\u5173\u8111\u8f6c\u79fb\u60a3\u8005\u5728WBRT\u7684\u57fa\u7840\u4e0a\u52a0\u7528\u4f0a\u5339\u5355\u6297(\u6297CTLA-4)\u4f3c\u4e4e\u6709\u66f4\u5927\u7684\u751f\u5b58\u4f18\u52bf\u3002\u6cbf\u7740\u8fd9\u4e9b\u601d\u8def\uff0c\u5bf9\u653e\u7597\u8bf1\u5bfc\u7684CTL\u53cd\u5e94\u7684\u4e34\u5e8a\u524d\u8bc4\u4f30\u8868\u660e\uff0c\u968f\u7740HLA-I\u7c7b\u6297\u539f\u5904\u7406\u548c\u5448\u9012\u7684\u6539\u53d8\uff0c\u7a81\u53d8\u7684\u683c\u5c40\u53d1\u751f\u4e86\u53d8\u5316\uff0c\u968f\u540e\u4f34\u968f\u7740\u5bf9\u80bf\u7624\u8d1f\u62c5\u7684\u52a0\u5f3a\u63a7\u5236\u3002<\/p>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

\u4e00\u822c\u800c\u8a00\uff0c\u7535\u79bb\u8f90\u5c04\u53ef\u4fc3\u8fdb\u514d\u75ab\u523a\u6fc0\u4e8b\u4ef6\uff0c\u5982(1)\u589e\u52a0HLA\u5206\u5b50\u8868\u8fbe\uff0cMHC-I\u8868\u8fbe\uff0c(2)\u4ea7\u751f\u4e0e\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u8bc6\u522b\u6709\u5173\u7684\u7279\u5f02\u6027\u591a\u80bd\uff0c(3)\u901a\u8fc7\u91ca\u653e\u80bf\u7624\u76f8\u5173\u6297\u539f\u4fc3\u8fdb\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u6d3b\u6027\u3002\u540e\u4e00\u79cd\u8fc7\u7a0b\u5bfc\u81f4\u6548\u5e94\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u8fd0\u8f93\uff0c\u4fc3\u8fdb\u539f\u4f4d\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\uff0c\u5c3d\u7ba1\u4e5f\u53ef\u80fd\u53d1\u751f\u8fdc\u8ddd\u79bb\u53cd\u5e94\u3002\u5728\u8fd9\u4e2a\u7279\u6b8a\u7684\u80cc\u666f\u4e0b\uff0c\u5242\u91cf\u548c\u5206\u7ea7\u4f3c\u4e4e\u5728\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u6548\u5e94\u65b9\u9762\u8d77\u7740\u51b3\u5b9a\u6027\u7684\u4f5c\u7528\u3002Demaria\u7ec4\u5728\u4e73\u817a\u764c\u548c\u7ed3\u80a0\u764c\u6a21\u578b\u4e0a\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c\u9664CTLA-4\u963b\u65ad\u5916\uff0c\u8054\u5408\u5c40\u90e8\u5206\u5272\u653e\u7597\u65b9\u6848(8gy\u00d73\uff0c6gy\u00d75)\u6709\u660e\u663e\u7684\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u7684\u8ff9\u8c61\uff0c\u5176\u4ed6\u4e34\u5e8a\u524d\/\u4e34\u5e8a\u7814\u7a76\u80fd\u591f\u652f\u6301\u8fd9\u79cd\u8054\u5408\u65b9\u6cd5\u7684\u76f8\u5173\u6027\u3002\u8003\u8651\u5230\u5355\u514b\u9686\u6297\u4f53\u5bf9CTLA-4\u548cPD-1\u8c03\u8282\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u5728\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u80be\u764c\u4e2d\u7684\u6291\u5236\u4f5c\u7528\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u8f90\u5c04\u5bf9\u5c40\u90e8\u548c\u8fdc\u5904\u7684\u6f5c\u5728\u8f85\u52a9\u4f5c\u7528\u662f\u5fc5\u8981\u7684\u3002Postow\u7b49\u4eba\u62a5\u9053\u4e86\u4e00\u4f8b\u88ab\u8bca\u65ad\u4e3a\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u60a3\u8005\uff0c\u7528\u4f0a\u5339\u5355\u6297\u6cbb\u7597\uff1b\u5728\u4e00\u4e2a\u9636\u6bb5\uff0c\u60a3\u8005\u63a5\u53d7\u4e86\u4f4e\u5206\u5272\u653e\u5c04\u6cbb\u7597\uff0c\u4ee5\u6cbb\u7597\u690e\u65c1\u8f6c\u79fb\uff1b\u60a3\u8005\u63a5\u53d7\u4e8628.5Gy\u7684\u6cbb\u7597\uff0c\u52063\u6b21\u8fdb\u884c\uff0c\u4e3a\u671f7\u5929\u30024\u52305\u4e2a\u6708\u540e\uff0c\u690e\u7ba1\u65c1\u80bf\u5757\u548c\u4e00\u7ec4\u5148\u524d\u53d1\u73b0\u7684\u8fdc\u5904\u80ba\u95e8\u6dcb\u5df4\u7ed3\u75c5\u53d8\u548c\u813e\u810f\u75c5\u53d8(\u4e0d\u662f\u653e\u5c04\u9776\u70b9)\u660e\u663e\u51cf\u5c11\u3002\u6cbb\u759710\u4e2a\u6708\u540eCT\u4ecd\u663e\u793a\u75c5\u60c5\u7a33\u5b9a\u3002\u5728\u66f4\u5927\u7684\u60a3\u8005\u7fa4\u4f53\u4e2d\u518d\u73b0\u8fd9\u4e9b\u6548\u5e94\u9700\u8981\u8003\u8651\u8bb8\u591a\u751f\u7269\u5b66\u548c\u4e34\u5e8a\u53d8\u91cf\uff0c\u5176\u4e2d\u5305\u62ec\u80fd\u591f\u63d0\u4f9b\u5173\u4e8e\u8f90\u5c04\u8bf1\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u7684\u5b9a\u6027\u548c\u5b9a\u91cf\u9884\u6d4b\u6570\u636e\u7684\u6570\u5b66\u6a21\u578b\u3002\u751a\u81f3\u53ef\u4ee5\u53cd\u6620\u201c\u7a81\u53d8\u8d1f\u8377\u201d\u548cT\u7ec6\u80de\u6d78\u6da6\u7684\u56fe\u50cf\u5206\u6790\u4e5f\u53ef\u80fd\u63d0\u4f9b\u4e00\u79cd\u9884\u6d4b\u5de5\u5177\uff0c\u540c\u65f6\u4e5f\u662f\u4e00\u79cd\u7528\u6765\u8861\u91cf\u9488\u5bf9\u7a81\u53d8\u6297\u539f\u7684T\u7ec6\u80de\u53cd\u5e94\u5e94\u8be5\u5982\u4f55\u201c\u96c6\u4e2d\u201d\u548c\u7f29\u5c0f\u6216\u6269\u5927\u7684\u5de5\u5177(\u89c1Fig 4.3<\/span>)\uff0c\u4ee5\u4fbf\u63d0\u4f9b\u66f4\u9ad8\u7684\u5b58\u6d3b\u7387\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 4.3 <\/span>\u5bf94\u4f8b\u80f6\u8d28\u7624\u60a3\u8005(WHO\u5206\u7ea7\u4e3a4\u7ea7)\u8fdb\u884cMRI\u626b\u63cf\uff0c\u4ee5(I)\u672f\u540e\u6570\u5929\u7684\u5b58\u6d3b\u65f6\u95f4\u548c(Ii)\u60a3\u8005TIL\u6240\u8bc6\u522b\u7684\u7a81\u53d8\u8868\u4f4d\u6570(\u7531IFN-\u03b3\u4ea7\u751f\u6240\u786e\u5b9a\u7684\u7a81\u53d8\u8868\u4f4d\u6570\u4e0e\u6240\u8bc6\u522b\u7684\u7a81\u53d8\u603b\u6570\u4e4b\u6bd4)\u4e3a\u6307\u6807\u3002\u96c6\u4e2d\u7684TIL\u5e94\u7b54\u4f3c\u4e4e\u4e0e\u63d0\u9ad8\u5b58\u6d3b\u7387\u6709\u5173\uff0c\u8fd9\u4e00\u89c2\u5bdf\u7ed3\u679c\u9700\u8981\u5728\u66f4\u5927\u89c4\u6a21\u7684\u7814\u7a76\u4e2d\u8fdb\u884c\u968f\u8bbf\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u672c<\/span>\u6587<\/span>\u7531<\/span>O<\/span>n<\/span>c<\/span>o<\/span>l<\/span>a<\/span>b<\/span>\u5fae<\/span>\u4fe1<\/span>\u516c<\/span>\u4f17<\/span>\u53f7<\/span>\u7ffb<\/span>\u8bd1<\/span>\u6574<\/span>\u7406<\/span>\u81ea<\/span>O<\/span>n<\/span>c<\/span>o<\/span>i<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>l<\/span>o<\/span>g<\/span>y<\/span>:<\/span> <\/span>A<\/span> <\/span>P<\/span>r<\/span>a<\/span>c<\/span>t<\/span>i<\/span>c<\/span>a<\/span>l<\/span> <\/span>G<\/span>u<\/span>i<\/span>d<\/span>e<\/span> <\/span>f<\/span>o<\/span>r<\/span> <\/span>C<\/span>a<\/span>n<\/span>c<\/span>e<\/span>r<\/span> <\/span>I<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>t<\/span>h<\/span>e<\/span>r<\/span>a<\/span>p<\/span>y<\/span>\uff0c<\/span>\u4ec5<\/span>\u7528<\/span>\u4e8e<\/span>\u5b66<\/span>\u4e60<\/span>\u4ea4<\/span>\u6d41<\/span>\u4f7f<\/span>\u7528<\/span>\uff0c<\/span>\u5982<\/span>\u9700<\/span>\u8d2d<\/span>\u4e70<\/span>\u539f<\/span>\u7248<\/span>\u4e66<\/span>\u7c4d<\/span>\u53ef<\/span>\u70b9<\/span>\u51fb<\/span>\u9605<\/span>\u8bfb<\/span>\u539f<\/span>\u6587<\/span>\u8d2d<\/span>\u4e70<\/span>\u3002<\/span><\/span>
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014<\/span> <\/span>T<\/span>H<\/span>E<\/span> <\/span> <\/span>E<\/span>N<\/span>D<\/span> <\/span>\u2014<\/span><\/span><\/p>\n


<\/p>\n

\u6765<\/span>\u6e90<\/span> <\/span>|<\/span> <\/span>O<\/span>n<\/span>c<\/span>o<\/span>i<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>l<\/span>o<\/span>g<\/span>y<\/span>:<\/span> <\/span>A<\/span> <\/span>P<\/span>r<\/span>a<\/span>c<\/span>t<\/span>i<\/span>c<\/span>a<\/span>l<\/span> <\/span>G<\/span>u<\/span>i<\/span>d<\/span>e<\/span> <\/span><\/span><\/section>\n
f<\/span>o<\/span>r<\/span> <\/span>C<\/span>a<\/span>n<\/span>c<\/span>e<\/span>r<\/span> <\/span>I<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>t<\/span>h<\/span>e<\/span>r<\/span>a<\/span>p<\/span>y<\/span><\/span><\/section>\n
\u4f5c<\/span>\u8005<\/span> <\/span>|<\/span> <\/span><\/span>M<\/span>artin Rao, Liu Zhenjiang, Qingda Meng, Georg<\/span>es Sinclair,<\/span><\/section>\n
        Ernest Dodoo, and Markus Maeurer<\/span><\/section>\n
\u7ffb<\/span>\u8bd1<\/span> <\/span>|<\/span> <\/span> \u5f90\u66fc\u65af <\/span><\/span><\/span><\/section>\n
\u7f16<\/span>\u8f91<\/span>\u6392<\/span>\u7248<\/span> <\/span>|\u7f57\u4f73\u4f73 <\/span><\/span><\/span><\/span><\/span><\/section>\n
\u521d<\/span>\u5ba1<\/span> <\/span>|<\/span> <\/span>\u5b8b<\/span>\u4e50<\/span> <\/span>\u9648<\/span>\u79cb<\/span>\u8c37<\/span><\/span><\/section>\n
\u7ec8<\/span>\u5ba1<\/span> <\/span>|<\/span> \u738b<\/span>\u5764 <\/span><\/span>\u8096<\/span>\u5efa<\/span>\u52c7<\/span><\/span><\/section>\n
\uff08<\/span>\u8f6c<\/span>\u8f7d<\/span>\u8bf7<\/span>\u4fdd<\/span>\u7559<\/span>\u6b64<\/span>\u90e8<\/span>\u5206<\/span>\u5185<\/span>\u5bb9<\/span>\uff09<\/span><\/span><\/strong><\/section>\n

<\/span><\/span><\/strong><\/section>\n

\u2589  \u5f80\u671f\u6587\u7ae0\u76ee\u5f55<\/strong><\/strong><\/span><\/p>\n

\u57fa<\/span>\u7840<\/span>\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u7cfb<\/span>\u5217<\/span><\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c24\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c23\u7ae0\uff1a\u708e\u75c7\u4e0e\u514d\u75ab<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c22\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u529f\u80fd<\/a><\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>2<\/span>1<\/span>\u7ae0<\/span>\uff1a<\/span>\u541e<\/span>\u566c<\/span>\u7ec6<\/span>\u80de<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>2<\/span>0<\/span>\u7ae0<\/span>\uff1a<\/span>\u56fa<\/span>\u6709<\/span>\u514d<\/span>\u75ab<\/span>\u7684<\/span>\u9632<\/span>\u5fa1<\/span>\u4f5c<\/span>\u7528<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>9<\/span>\u7ae0<\/span>\uff1a<\/span>\u514d<\/span>\u75ab<\/span>\u7cfb<\/span>\u7edf<\/span>\u751f<\/span>\u7406<\/span>\u529f<\/span>\u80fd<\/span>\u7b80<\/span>\u8ff0<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>8<\/span>\u7ae0<\/span>\uff1a<\/span>\u514d<\/span>\u75ab<\/span>\u7cfb<\/span>\u7edf<\/span>\u7684<\/span>\u8c03<\/span>\u8282<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>7<\/span>\u7ae0<\/span>\uff1a<\/span>\u514d<\/span>\u75ab<\/span>\u8bb0<\/span>\u5fc6<\/span>\u4e0e<\/span>\u6dcb<\/span>\u5df4<\/span>\u7ec6<\/span>\u80de<\/span>\u7a33<\/span>\u6001<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>6<\/span>\u7ae0<\/span>\uff1a<\/span>T<\/span>\u7ec6<\/span>\u80de<\/span>\u4e0e<\/span>\u5176<\/span>\u4ed6<\/span>\u514d<\/span>\u75ab<\/span>\u7ec6<\/span>\u80de<\/span>\u95f4<\/span>\u7684<\/span>\u76f8<\/span>\u4e92<\/span>\u4f5c<\/span>\u7528<\/span><\/a><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>5<\/span>\u7ae0<\/span>\uff1a<\/span>T<\/span>\u7ec6<\/span>\u80de<\/span>\u7684<\/span>\u53d1<\/span>\u80b2<\/span><\/a><\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>4<\/span>\u7ae0<\/span>\uff1a<\/span>B<\/span>\u7ec6<\/span>\u80de<\/span>\u7684<\/span>\u53d1<\/span>\u80b2<\/span><\/a><\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>3<\/span>\u7ae0<\/span>\uff1a<\/span>\u514d<\/span>\u75ab<\/span>\u7cfb<\/span>\u7edf<\/span>\u7684<\/span>\u5668<\/span>\u5b98<\/span>\u548c<\/span>\u7ec4<\/span>\u7ec7<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>2<\/span>\u7ae0<\/span>\uff1a<\/span>\u9020<\/span>\u8840<\/span>\u529f<\/span>\u80fd<\/span>–<\/span>\u8840<\/span>\u7ec6<\/span>\u80de<\/span>\u751f<\/span>\u6210<\/span><\/a>
<\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>1<\/span>\u7ae0<\/span>\uff1a<\/span>\u6dcb<\/span>\u5df4<\/span>\u7ec6<\/span>\u80de<\/span>\u6d3b<\/span>\u5316<\/span><\/a><\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>0<\/span>\u7ae0<\/span>\uff1a<\/span>\u6297<\/span>\u539f<\/span>\u7684<\/span>\u5904<\/span>\u7406<\/span>\u548c<\/span>\u5448<\/span>\u9012<\/span><\/a><\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>9<\/span>\u7ae0<\/span>\uff1a<\/span>\u6297<\/span>\u539f<\/span>\u8bc6<\/span>\u522b<\/span>\u7814<\/span>\u7a76<\/span>\u8fdb<\/span>\u5c55<\/span><\/a><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>8<\/span>\u7ae0<\/span>\uff1a<\/span>\u4e3b<\/span>\u8981<\/span>\u7ec4<\/span>\u7ec7<\/span>\u76f8<\/span>\u5bb9<\/span>\u6027<\/span>\u590d<\/span>\u5408<\/span>\u7269<\/span>M<\/span>H<\/span>C<\/span><\/a><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>7<\/span>\u7ae0<\/span>\uff1a<\/span>T<\/span>\u7ec6<\/span>\u80de<\/span>\u53d7<\/span>\u4f53<\/span>(<\/span>T<\/span>C<\/span>R<\/span>)<\/span>\u6982<\/span>\u8ff0<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>6<\/span>\u7ae0<\/span>\uff1a<\/span>\u6297<\/span>\u4f53<\/span>\u591a<\/span>\u6837<\/span>\u6027<\/span><\/a><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>5<\/span>\u7ae0<\/span>\uff1a<\/span>\u6297<\/span>\u4f53<\/span>–<\/span>\u6297<\/span>\u539f<\/span>\u76f8<\/span>\u4e92<\/span>\u4f5c<\/span>\u7528<\/span><\/a><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>4<\/span>\u7ae0<\/span>\uff1a<\/span>\u6297<\/span>\u539f<\/span>\u548c<\/span>\u6297<\/span>\u4f53<\/span>\u7ed3<\/span>\u6784<\/span><\/a><\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>3<\/span>\u7ae0<\/span>\uff1a<\/span>\u6297<\/span>\u539f<\/span>\u8bc6<\/span>\u522b<\/span><\/a><\/span><\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>2<\/span>\u7ae0<\/span>\uff1a<\/span>\u514d<\/span>\u75ab<\/span>\u7cfb<\/span>\u7edf<\/span>\u7684<\/span>\u57fa<\/span>\u672c<\/span>\u6982<\/span>\u5ff5<\/span>\u548c<\/span>\u7ec4<\/span>\u6210<\/span><\/a><\/span>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u62fe<\/span>\u9057<\/span>–<\/span>\u7b2c<\/span>1<\/span>\u7ae0<\/span>\uff1a<\/span>\u514d<\/span>\u75ab<\/span>\u7cfb<\/span>\u7edf<\/span>\u7b80<\/span>\u4ecb<\/span><\/a><\/span><\/p>\n

\u80bf<\/span>\u7624<\/span>\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u7cfb<\/span>\u5217<\/span><\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c3\u7ae0\uff1aCD8+ T\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u548c\u5316\u7597\u4e2d\u7684\u4f5c\u7528\uff08\u4e0b\uff09<\/span><\/a>
<\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c3\u7ae0\uff1aCD8+ T\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u548c\u5316\u7597\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09<\/span><\/a>
<\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0b\uff09<\/span><\/a>
<\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0a\uff09<\/a><\/p>\n

\u80bf<\/span>\u7624<\/span>\u514d<\/span>\u75ab<\/span>\u5b66<\/span>–<\/span>\u7b2c<\/span>1<\/span>\u7ae0<\/span>\uff1a<\/span>\u80bf<\/span>\u7624<\/span>\u514d<\/span>\u75ab<\/span>\u7b80<\/span>\u53f2<\/span><\/a>
<\/span><\/p>\n

\u80bf<\/span>\u7624<\/span>\u514d<\/span>\u75ab<\/span>\u5b66<\/span>\u7cfb<\/span>\u5217<\/span>\u66f4<\/span>\u65b0<\/span>\u9884<\/span>\u544a<\/span><\/a>
<\/span><\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>\u7cfb<\/span>\u5217<\/span><\/strong><\/strong><\/span><\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>(<\/span>\u7b2c<\/span>7<\/span>\u5929<\/span>)<\/span>–<\/span>2<\/span>1<\/span>0<\/span>6<\/span>0<\/span>8<\/span><\/a>
<\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>(<\/span>\u7b2c<\/span>6<\/span>\u5929<\/span>)<\/span>–<\/span>2<\/span>1<\/span>0<\/span>6<\/span>0<\/span>7<\/span><\/a>
<\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>(<\/span>\u7b2c<\/span>5<\/span>\u5929<\/span>)<\/span>–<\/span>2<\/span>1<\/span>0<\/span>6<\/span>0<\/span>5<\/span><\/a>
<\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>(<\/span>\u7b2c<\/span>4<\/span>\u5929<\/span>)<\/span>–<\/span>2<\/span>1<\/span>0<\/span>6<\/span>0<\/span>4<\/span><\/a><\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>(<\/span>\u7b2c<\/span>3<\/span>\u5929<\/span>)<\/span>–<\/span>2<\/span>1<\/span>0<\/span>6<\/span>0<\/span>3<\/span><\/a>
<\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>(<\/span>\u7b2c<\/span>1<\/span>\u5929<\/span>)<\/span>–<\/span>2<\/span>0<\/span>2<\/span>1<\/span>0<\/span>5<\/span>3<\/span>1<\/span><\/a><\/span><\/p>\n

\u751f<\/span>\u4fe1<\/span>\u5165<\/span>\u95e8<\/span>\u5b66<\/span>\u4e60<\/span>\u7b14<\/span>\u8bb0<\/span>(<\/span>\u7b2c<\/span>2<\/span>\u5929<\/span>)<\/span>–<\/span>2<\/span>0<\/span>2<\/span>1<\/span>0<\/span>6<\/span>0<\/span>1<\/span><\/a><\/p>\n

T<\/span>C<\/span>G<\/span>A<\/span>\u514d<\/span>\u75ab<\/span>\u6d78<\/span>\u6da6<\/span>\u8bc4<\/span>\u4ef7<\/span>\u6570<\/span>\u636e<\/span>\u5e93<\/span><\/a>
<\/p>\n

g<\/span>g<\/span>p<\/span>l<\/span>o<\/span>t<\/span>2<\/span>|<\/span>\u8be6<\/span>\u89e3<\/span>\u516b<\/span>\u5927<\/span>\u57fa<\/span>\u672c<\/span>\u7ed8<\/span>\u56fe<\/span>\u8981<\/span>\u7d20<\/span><\/a>
<\/p>\n

P<\/span>y<\/span>t<\/span>h<\/span>o<\/span>n<\/span>\u96c6<\/span>\u6210<\/span>\u5f00<\/span>\u53d1<\/span>\u73af<\/span>\u5883<\/span>P<\/span>y<\/span>C<\/span>h<\/span>a<\/span>r<\/span>m<\/span>\u7684<\/span>\u5b89<\/span>\u88c5<\/span>\u4e0e<\/span>\u6fc0<\/span>\u6d3b<\/span><\/a>
<\/p>\n

P<\/span>y<\/span>t<\/span>h<\/span>o<\/span>n<\/span>\u53d1<\/span>\u884c<\/span>\u7248<\/span>A<\/span>n<\/span>a<\/span>c<\/span>o<\/span>n<\/span>d<\/span>a<\/span>\u7684<\/span>\u5b89<\/span>\u88c5<\/span>\u4e0e<\/span>\u4f7f<\/span>\u7528<\/span><\/a><\/p>\n

\u57fa<\/span>\u7840<\/span>\u5b9e<\/span>\u9a8c<\/span>\u6280<\/span>\u672f<\/span>\u7cfb<\/span>\u5217<\/span><\/strong><\/strong><\/span><\/p>\n

\u6d41<\/span>\u5f0f<\/span>\u68c0<\/span>\u6d4b<\/span>\u7ec6<\/span>\u80de<\/span>\u603b<\/span>R<\/span>O<\/span>S<\/span>–<\/span>O<\/span>n<\/span>c<\/span>o<\/span>L<\/span>a<\/span>b<\/span>\u5b9e<\/span>\u9a8c<\/span>\u5ba4<\/span><\/a><\/span>
<\/p>\n

A<\/span>n<\/span>n<\/span>e<\/span>x<\/span>i<\/span>n<\/span> <\/span>V<\/span>\/<\/span>P<\/span>I<\/span>\u67d3<\/span>\u8272<\/span>\u68c0<\/span>\u6d4b<\/span>\u7ec6<\/span>\u80de<\/span>\u51cb<\/span>\u4ea1<\/span>–<\/span>O<\/span>n<\/span>c<\/span>o<\/span>L<\/span>a<\/span>b<\/span>\u5b9e<\/span>\u9a8c<\/span>\u5ba4<\/span><\/a>
<\/p>\n

\u514d<\/span>\u75ab<\/span>\u8367<\/span>\u5149<\/span>\u5b9e<\/span>\u9a8c<\/span>–<\/span>O<\/span>n<\/span>c<\/span>o<\/span>L<\/span>a<\/span>b<\/span>\u5b9e<\/span>\u9a8c<\/span>\u5ba4<\/span><\/a>
<\/p>\n

W<\/span>B<\/span>\u64cd<\/span>\u4f5c<\/span>\u89c6<\/span>\u9891<\/span>–<\/span>O<\/span>n<\/span>c<\/span>o<\/span>L<\/span>a<\/span>b<\/span>\u5b9e<\/span>\u9a8c<\/span>\u5ba4<\/span><\/a><\/span><\/p>\n

Q<\/span>P<\/span>C<\/span>R<\/span>\u5b9e<\/span>\u9a8c<\/span>\u64cd<\/span>\u4f5c<\/span>\u89c6<\/span>\u9891<\/span>–<\/span>O<\/span>n<\/span>c<\/span>o<\/span>L<\/span>a<\/span>b<\/span>\u5b9e<\/span>\u9a8c<\/span>\u5ba4<\/span><\/a>
<\/p>\n

\u4eea<\/span>\u5668<\/span>\u64cd<\/span>\u4f5c<\/span>\u7cfb<\/span>\u5217<\/span><\/strong><\/strong><\/span><\/p>\n

\u5c0f<\/span>\u52a8<\/span>\u7269<\/span>\u6d3b<\/span>\u4f53<\/span>\u5149<\/span>\u5b66<\/span>\u6210<\/span>\u50cf<\/span>\u7cfb<\/span>\u7edf<\/span>\u64cd<\/span>\u4f5c<\/span>\u89c6<\/span>\u9891<\/span>–<\/span>\u4e2d<\/span>\u897f<\/span>\u533b<\/span>\u7ed3<\/span>\u5408<\/span>\u57fa<\/span>\u7840<\/span>\u7814<\/span>\u7a76<\/span>\u4e2d<\/span>\u5fc3<\/span><\/a>
<\/p>\n

\u8521<\/span>\u53f8<\/span>L<\/span>S<\/span>M<\/span>8<\/span>0<\/span>0<\/span>\u6fc0<\/span>\u5149<\/span>\u5171<\/span>\u805a<\/span>\u7126<\/span>\u663e<\/span>\u5fae<\/span>\u955c<\/span>\u64cd<\/span>\u4f5c<\/span>\u89c6<\/span>\u9891<\/span>–<\/span>\u4e2d<\/span>\u897f<\/span>\u533b<\/span>\u7ed3<\/span>\u5408<\/span>\u57fa<\/span>\u7840<\/span>\u7814<\/span>\u7a76<\/span>\u4e2d<\/span>\u5fc3<\/span><\/a>
<\/p>\n

I<\/span>N<\/span> <\/span>C<\/span>e<\/span>l<\/span>l<\/span> <\/span>A<\/span>n<\/span>a<\/span>l<\/span>y<\/span>z<\/span>e<\/span>r<\/span>2<\/span>2<\/span>0<\/span>0<\/span>\u9ad8<\/span>\u5185<\/span>\u6db5<\/span>\u7ec6<\/span>\u80de<\/span>\u6210<\/span>\u50cf<\/span>\u5206<\/span>\u6790<\/span>\u7cfb<\/span>\u7edf<\/span>\u64cd<\/span>\u4f5c<\/span>\u6559<\/span>\u7a0b<\/span>–<\/span>\u4e2d<\/span>\u897f<\/span>\u533b<\/span>\u7ed3<\/span>\u5408<\/span>\u57fa<\/span>\u7840<\/span>\u7814<\/span>\u7a76<\/span>\u4e2d<\/span>\u5fc3<\/span><\/a>
<\/p>\n

B<\/span>D<\/span> <\/span>L<\/span>S<\/span>R<\/span> <\/span>F<\/span>o<\/span>r<\/span>t<\/span>e<\/span>s<\/span>s<\/span>a<\/span>\u6d41<\/span>\u5f0f<\/span>–<\/span>\u4e2d<\/span>\u897f<\/span>\u533b<\/span>\u7ed3<\/span>\u5408<\/span>\u57fa<\/span>\u7840<\/span>\u7814<\/span>\u7a76<\/span>\u4e2d<\/span>\u5fc3<\/span><\/a><\/span><\/p>\n

\u6587<\/span>\u732e<\/span>\u5206<\/span>\u4eab<\/span>\u7cfb<\/span>\u5217<\/span><\/strong><\/strong><\/span><\/p>\n

\u80bf<\/span>\u7624<\/span>\u4ee3<\/span>\u8c22<\/span>\u91cd<\/span>\u7f16<\/span>\u7a0b<\/span>\u4e0e<\/span>\u514d<\/span>\u75ab<\/span>\u5e94<\/span>\u7b54<\/span><\/a>
<\/p>\n

\u5e74<\/span>\u5ea6<\/span>\u5de8<\/span>\u732e<\/span>\uff1a<\/span>\u795e<\/span>\u520a<\/span>C<\/span>A<\/span>\u53d1<\/span>\u5e03<\/span>\u6700<\/span>\u65b0<\/span>\u764c<\/span>\u75c7<\/span>\u6570<\/span>\u636e<\/span>\uff1a<\/span>\u5168<\/span>\u7403<\/span>1<\/span>0<\/span>0<\/span>0<\/span>\u4e07<\/span>\u4eba<\/span>\u6b7b<\/span>\u4e8e<\/span>\u764c<\/span>\u75c7<\/span>\uff0c<\/span>\u4e2d<\/span>\u56fd<\/span>\u5360<\/span>\u6bd4<\/span>\u8d85<\/span>3<\/span>\u6210<\/span><\/a>
<\/p>\n

H<\/span>L<\/span>A<\/span>–<\/span>I<\/span>\u5206<\/span>\u5b50<\/span>\u52a0<\/span>\u5de5<\/span>\u548c<\/span>\u9012<\/span>\u5448<\/span>\u6297<\/span>\u539f<\/span>\u529f<\/span>\u80fd<\/span>\u53d7<\/span>\u635f<\/span>\u662f<\/span>\u514d<\/span>\u75ab<\/span>\u68c0<\/span>\u67e5<\/span>\u70b9<\/span>\u6291<\/span>\u5236<\/span>\u5242<\/span>\u8010<\/span>\u836f<\/span>\u7684<\/span>\u91cd<\/span>\u8981<\/span>\u539f<\/span>\u56e0<\/span><\/a>
<\/p>\n

P<\/span>D<\/span>–<\/span>1<\/span>\/<\/span>P<\/span>D<\/span>–<\/span>L<\/span>1<\/span>\u963b<\/span>\u65ad<\/span>\u5242<\/span>\u6cbb<\/span>\u7597<\/span>\u80bf<\/span>\u7624<\/span>\u7684<\/span>\u7814<\/span>\u7a76<\/span>\u8fdb<\/span>\u5c55<\/span>\u4e0e<\/span>\u9762<\/span>\u4e34<\/span>\u7684<\/span>\u6311<\/span>\u6218<\/span><\/a><\/span><\/p>\n

I<\/span>m<\/span>m<\/span>u<\/span>n<\/span>i<\/span>t<\/span>y<\/span>\uff1a<\/span>\u80bf<\/span>\u7624<\/span>\u514d<\/span>\u75ab<\/span>\u6cbb<\/span>\u7597<\/span>\u7684<\/span>\u5341<\/span>\u5927<\/span>\u6311<\/span>\u6218<\/span><\/span><\/a><\/p>\n

\u4f5c<\/span>\u56fe<\/span>\u6295<\/span>\u7a3f<\/span>\u9009<\/span>\u520a<\/span>\u7cfb<\/span>\u5217<\/span><\/strong><\/strong><\/span><\/p>\n

G<\/span>r<\/span>a<\/span>p<\/span>h<\/span>P<\/span>a<\/span>d<\/span>+<\/span>A<\/span>I<\/span>\u5236<\/span>\u4f5c<\/span>\u53ef<\/span>\u53d1<\/span>\u8868<\/span>\u7ea7<\/span>\u522b<\/span>\u7684<\/span>\u67f1<\/span>\u72b6<\/span>\u56fe<\/span>–<\/span>O<\/span>n<\/span>c<\/span>o<\/span>L<\/span>a<\/span>b<\/span>\u5b9e<\/span>\u9a8c<\/span>\u5ba4<\/span><\/a>
<\/p>\n

\u5982<\/span>\u4f55<\/span>\u4f7f<\/span>\u7528<\/span>I<\/span>m<\/span>a<\/span>g<\/span>e<\/span>J<\/span>\u8fdb<\/span>\u884c<\/span>\u7ec6<\/span>\u80de<\/span>\u8367<\/span>\u5149<\/span>\u5b9a<\/span>\u91cf<\/span><\/a>
<\/p>\n

\u5982<\/span>\u4f55<\/span>\u4f7f<\/span>\u7528<\/span>S<\/span>c<\/span>r<\/span>i<\/span>v<\/span>e<\/span>n<\/span>e<\/span>r<\/span>\u8fdb<\/span>\u884c<\/span>\u79d1<\/span>\u6280<\/span>\u8bba<\/span>\u6587<\/span>\u5199<\/span>\u4f5c<\/span><\/a>
<\/p>\n

M<\/span>e<\/span>n<\/span>d<\/span>e<\/span>l<\/span>e<\/span>y<\/span>–<\/span>\u6700<\/span>\u597d<\/span>\u7528<\/span>\u7684<\/span>\u6587<\/span>\u732e<\/span>\u9605<\/span>\u8bfb<\/span>\u7ba1<\/span>\u7406<\/span>\u8f6f<\/span>\u4ef6<\/span>\uff0c<\/span>\u6ca1<\/span>\u6709<\/span>\u4e4b<\/span>\u4e00<\/span><\/a>
<\/p>\n

\u5982<\/span>\u4f55<\/span>\u9009<\/span>\u62e9<\/span>\u4e00<\/span>\u4e2a<\/span>\u5408<\/span>\u9002<\/span>\u7684<\/span>\u6742<\/span>\u5fd7<\/span>\u8fdb<\/span>\u884c<\/span>\u6295<\/span>\u7a3f<\/span>\uff1f<\/span><\/a>
<\/p>\n

P<\/span>u<\/span>b<\/span>M<\/span>e<\/span>d<\/span>\u4e2d<\/span>\u5982<\/span>\u4f55<\/span>\u6309<\/span>\u5f71<\/span>\u54cd<\/span>\u56e0<\/span>\u5b50<\/span>\u7b5b<\/span>\u9009<\/span>\u68c0<\/span>\u7d22<\/span>\u7ed3<\/span>\u679c<\/span>\u5e76<\/span>\u663e<\/span>\u793a<\/span>\u5f71<\/span>\u54cd<\/span>\u56e0<\/span>\u5b50<\/span>\u53ca<\/span>\u5206<\/span>\u533a<\/span>\uff1f<\/span><\/a>
<\/p>\n

\u5982<\/span>\u4f55<\/span>\u4f7f<\/span>\u7528<\/span>E<\/span>n<\/span>d<\/span>N<\/span>o<\/span>t<\/span>e<\/span>\u8f6f<\/span>\u4ef6<\/span>\u63d2<\/span>\u5165<\/span>\u53c2<\/span>\u8003<\/span>\u6587<\/span>\u732e<\/span>\uff08<\/span>\u9644<\/span>6<\/span>8<\/span>1<\/span>3<\/span>\u79cd<\/span>\u6742<\/span>\u5fd7<\/span>\u53c2<\/span>\u8003<\/span>\u6587<\/span>\u732e<\/span>\u683c<\/span>\u5f0f<\/span>\u6587<\/span>\u4ef6<\/span>\uff09<\/span><\/a><\/span><\/span><\/strong><\/strong><\/p>\n

\u4e2d\u533b\u4e2d\u836f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u516b\u6bb5\u9526\uff08\u89c6\u9891\u7248+\u56fe\u7247\u7248\uff0c\u63a8\u8350\u6536\u85cf\uff09<\/span><\/a>
<\/p>\n

\u4e2d\u6210\u836f\u4f20\u7edf\u65b9\u5242\u4ea4\u53c9\u68c0\u7d22\u6570\u636e\u5e93\u4f7f\u7528\u8bf4\u660e<\/span><\/a><\/p>\n

<\/span><\/span><\/a>
<\/p>\n


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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5173<\/span>\u6ce8<\/span>\u672c<\/span>\u53f7<\/span>~<\/span><\/span><\/p>\n


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<\/p>\n

\u52a0<\/span>\u5165<\/span>\u8bfb<\/span>\u8005<\/span>\u4ea4<\/span>\u6d41<\/span>\u7fa4<\/span>~<\/span><\/span><\/p>\n


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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9<\/span>\u4eae<\/span>\u201c<\/span>\u5728<\/span>\u770b<\/span>\u201d<\/span><\/span><\/section>\n
\u8ba9<\/span>\u66f4<\/span>\u591a<\/span>\u4eba<\/span>\u770b<\/span>\u5230<\/span>\uff01<\/span><\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

4.4 \u65b0\u8868\u4f4d\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u7684\u4e34\u5e8a\u610f\u4e49 \u65b0\u8868\u4f4d\u7279\u5f02\u6027\u53cd\u5e94\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u4e2d\u7684\u4e34\u5e8a\u4ef7\u503c\u6700\u4e3a\u660e\u663e\u3002\u6297PD-1\u548c\u6297CTLA-4\u5355\u6297\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u75c5\u4f8b\u62a5\u9053\u8868\u660e\uff0c\u65b0\u6297\u539f\u8bf1\u5bfc…<\/p>\n","protected":false},"author":1,"featured_media":3765,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3779"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3779"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3779\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3765"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3779"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}