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\u514d\u75ab\u7ec6\u80de\u8fc7\u7ee7\u7597\u6cd5\u662f\u73b0\u4ee3\u6cbb\u7597\u80bf\u7624\u7684\u4e00\u79cd\u91cd\u8981\u65b9\u6cd5\u3002<\/span>\u4f5c\u7528\u539f\u7406\u4e3b\u8981\u662f\u53d6\u51fa\u80bf\u7624\u60a3\u8005\u4f53\u5185\u90e8\u5206\u6709\u6f5c\u529b\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u7531\u591a\u79cd\u514d\u75ab\u56e0\u5b50\u523a\u6fc0\u8bf1\u5bfc\uff0c\u7ecf\u8fc7\u4f53\u5916\u5e72\u9884\uff0c\u6269\u589e\u5176\u6570\u91cf\uff0c\u6fc0\u6d3b\u548c\u5f3a\u5316\u5176\u529f\u80fd\uff0c\u5e76\u6559\u4f1a\u5b83\u4eec\u5982\u4f55\u8bc6\u522b\u673a\u4f53\u5185\u7684\u5f02\u5e38\u7ec6\u80de\uff0c\u5982\u6076\u6027\u80bf\u7624\u7ec6\u80de\u6216\u8005\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\uff0e\u7136\u540e\u518d\u56de\u8f93\u5230\u60a3\u8005\u81ea\u5df1\u4f53\u5185\u3002<\/span>\u5176\u6740\u4f24\u673a\u5236\u8868\u73b0\u4e3a\u76f4\u63a5\u6740\u4f24\u4f5c\u7528\u548c\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u53c2\u4e0e\u7684\u95f4\u63a5\u6740\u4f24\u4f5c\u7528\u3002<\/span><\/section>\n
<\/section>\n
\u5e94\u7528\u8f6c\u57fa\u56e0T\u7ec6\u80de\u8fdb\u884c\u8fc7\u7ee7\u7ec6\u80de\u6cbb\u7597\u5df2\u88ab\u8bc1\u660e\u5bf9\u8840\u6db2\u6076\u6027\u80bf\u7624\u6709\u79ef\u6781\u7684\u5f71\u54cd\uff0c\u4f46\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u7684\u5e94\u7528\u5c1a\u672a\u88ab\u5b8c\u5168\u53d1\u6398\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u5de8\u566c\u7ec6\u80de\u662f\u4e00\u79cd\u529f\u80fd\u5f3a\u5927\u7684\u514d\u75ab\u6548\u5e94\u7ec6\u80de\uff0c\u53ef\u5851\u6027\u5f3a\uff0c\u53ef\u5728\u4e0d\u540c\u7684\u73af\u5883\u4e2d\u53d1\u6325\u6297\u80bf\u7624\u548c\u4fc3\u80bf\u7624\u529f\u80fd\uff0c\u8fd9\u79cd\u53ef\u5851\u6027\u5bfc\u81f4\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7684\u590d\u6781\u5316\u3002\u53e6\u5916\uff0c\u5de8\u566c\u7ec6\u80de\u4e5f\u53ef\u4ee5\u5728\u4f53\u5916\u57fa\u56e0\u4fee\u9970\u540e\u8fc7\u7ee7\u8f6c\u79fb\u3002<\/span><\/section>\n
<\/section>\n
\u8fd9\u7bc7\u7efc\u8ff0\u7740\u91cd\u4ecb\u7ecd\u4e86\u5de8\u566c\u7ec6\u80de\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\u548c\u5de8\u566c\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u7684\u8fdb\u5c55\uff0c\u4ee5\u53ca\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u5de8\u566c\u7ec6\u80de\u6cbb\u7597\u7684\u51fa\u73b0\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n

\u6587\u7ae0\u540d\uff1a<\/span><\/strong>Macrophage-Based Approaches for Cancer Immunotherapy<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u6742\u5fd7\uff1a<\/span><\/strong>Cancer Research<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u5f71\u54cd\u56e0\u5b50<\/span><\/strong>\uff1a12.701<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a<\/span><\/strong>2021\u5e743\u6708<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u4f34\u968f\u7740\u57fa\u56e0\u5de5\u7a0bT\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u5408\u6210\u57fa\u56e0\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7684\u9057\u4f20\u6574\u5408\u53ef\u4ee5\u4ea7\u751f\u5927\u91cf\u7684T\u7ec6\u80de\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u7edf\u4e00\u9488\u5bf9\u7279\u5b9a\u7684\u80bf\u7624\u6297\u539f\uff0c\u514b\u670d\u4e86\u5bf9\u5185\u6e90\u6027TCR\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u529f\u80fd\u7684\u4f9d\u8d56\uff0c\u6269\u5927\u4e86\u9776\u5411\u80bf\u7624\u6297\u539f\u7684\u8303\u56f4\u3002<\/span><\/section>\n
\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8be5\u9886\u57df\u7684\u5927\u591a\u6570\u7814\u7a76\u90fd\u96c6\u4e2d\u5728\u6dcb\u5df4\u7ec6\u80de\u6765\u6e90\u7684\u7ec6\u80de\u7597\u6cd5\u7684\u53d1\u5c55\u4e0a\uff0c\u4f46\u5b83\u4eec\u5728\u5b9e\u4f53\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u6709\u6548\u6027\u4ecd\u7136\u96be\u4ee5\u4fdd\u8bc1\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n

\u80bf\u7624\u4e2d\u7684\u5de8\u566c\u7ec6\u80de\uff1a<\/span><\/strong><\/p>\n

\u00a0<\/span><\/section>\n
\u5de8\u566c\u7ec6\u80de\u662f\u9ad8\u5ea6\u53ef\u5851\u6027\u7684\u7ec6\u80de\uff0c\u5177\u6709\u7ef4\u6301\u7ec4\u7ec7\u53d1\u80b2\u548c\u7a33\u6001\u3001\u6e05\u9664\u7ec6\u80de\u788e\u7247\u3001\u6e05\u9664\u75c5\u539f\u4f53\u548c\u8c03\u8282\u708e\u75c7\u53cd\u5e94\u7b49\u529f\u80fd\uff0c\u5e76\u901a\u8fc7M-CSF\u6216GM-CSF\u4f9d\u8d56\u7684\u5faa\u73af\u5355\u6838\u7ec6\u80de\u8fdb\u884c\u5206\u5316\u3002\u901a\u5e38\u5c06\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u72b6\u6001\u5206\u4e3a\u4e24\u7c7b\uff1aM1\u7ecf\u5178\u6fc0\u6d3b\u7684\u5de8\u566c\u7ec6\u80de\u6216M2\u4ea4\u66ff\u6fc0\u6d3b\u7684\u5de8\u566c\u7ec6\u80de\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
M1<\/span>\u5de8\u566c\u7ec6\u80de\u901a\u8fc7\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u5982TNF\uff0cIL1\u548cIL-12\u4fc3\u8fdb\u4fc3\u708eTh1\u53cd\u5e94\uff0c\u5e76\u901a\u8fc7\u5206\u6ccc\u8d8b\u5316\u56e0\u5b50CXCL9\u548cCXCL10\u589e\u5f3aTh1\u7ec6\u80de\u5411\u708e\u75c7\u90e8\u4f4d\u7684\u52df\u96c6\u3002\u6b64\u5916\uff0cM1\u5de8\u566c\u7ec6\u80de\u4e0a\u8c03\u4e0e\u6297\u539f\u5904\u7406\u548c\u5448\u9012\u6709\u5173\u7684\u57fa\u56e0\uff0c\u4ee5\u53ca\u534f\u540c\u523a\u6fc0\u5206\u5b50\u4ee5\u589e\u5f3aT\u7ec6\u80de\u53cd\u5e94\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
M2<\/span>\u5de8\u566c\u7ec6\u80de\u53ef\u6291\u5236\u5bbf\u4e3b\u514d\u75ab\u7684\u6297\u708e\u4f5c\u7528\uff0c\u4fc3\u8fdb\u80bf\u7624\u95f4\u8d28\u7684\u91cd\u5851\u3001\u80bf\u7624\u7684\u53d1\u5c55\u548c\u4fb5\u88ad\u3002IL-4\uff0cIL-13\u548c\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b21\uff08TGF-\u03b21\uff09\u7b49\u7ec6\u80de\u56e0\u5b50\uff0c\u4fc3\u8fdb\u5de8\u566c\u7ec6\u80de\u5411M2-TAMs\u6781\u5316\uff0c\u5176\u4e3a\u80bf\u7624\u8fdb\u5c55\u548c\u8f6c\u79fb\u63d0\u4f9b\u5fc5\u8981\u6761\u4ef6\u3002<\/span><\/section>\n

\u00a0<\/span><\/p>\n

\u80bf\u7624\u9776\u5411TAMs<\/span><\/strong><\/p>\n

\u00a0<\/span><\/p>\n

TAMs<\/span>\u901a\u8fc7\u5206\u6cccIL-17\u548cIL-23\u7b49\u7ec6\u80de\u56e0\u5b50\u6765\u4fc3\u8fdb\u708e\u75c7\u73af\u5883\uff0c\u5e76\u4e0a\u8c03\u514d\u75ab\u6291\u5236\u8868\u9762\u86cb\u767d\u3001\u5206\u6ccc\u6d3b\u6027\u6c27\u3001\u4ea7\u751f\u6291\u5236T\u7ec6\u80de\u529f\u80fd\u7684\u7ec6\u80de\u56e0\u5b50\u4ee5\u53ca\u5206\u6ccc\u52df\u96c6\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u8d8b\u5316\u56e0\u5b50\uff0c\u5728\u6291\u5236\u5185\u6e90\u6027\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u6b64\u5916\uff0cTAMs\u8fd8\u901a\u8fc7\u5206\u6cccVEGF\u548cMMP\u7b49\u56e0\u5b50\u6765\u4fc3\u8fdb\u80bf\u7624\u8840\u7ba1\u751f\u6210\u548c\u8f6c\u79fb\uff0c\u8fd9\u4e9b\u56e0\u5b50\u53ef\u4ee5\u91cd\u5851TME\uff0c\u589e\u52a0\u8840\u7ba1\u5f62\u6210\uff0c\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u8fc1\u79fb\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u9274\u4e8eTAMs\u7684\u4fc3\u764c\u4f5c\u7528\uff0c\u5df2\u7ecf\u5f00\u53d1\u4e86\u8bb8\u591a\u7b56\u7565\u6765\u5bf9\u6297\u8fd9\u4e9b\u7ec6\u80de\u7684\u5f71\u54cd\u3002\u5927\u4f53\u4e0a\uff0c\u8fd9\u4e9b\u7b56\u7565\u53ef\u4ee5\u5206\u4e3a\u4e24\u7ec4\uff1a\u51cf\u5c11TAM\u7684\u6570\u91cf<\/strong>\u6216\u6539\u53d8\u5176\u5728TME\u4e2d\u7684\u529f\u80fd<\/strong>\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u9650\u5236\u80bf\u7624\u5185TAM\u7684\u6570\u91cf<\/span>\u53ef\u4ee5\u901a\u8fc7\u6d88\u9664\u73b0\u6709\u7684TAM\u6216\u6291\u5236\u8fdb\u4e00\u6b65\u7684TAM\u6765\u5b9e\u73b0\u3002\u6700\u6210\u719f\u7684\u51cf\u5c11TAM\u5b58\u6d3b\u7684\u65b9\u6cd5\u662f\u901a\u8fc7\u963b\u65ad\u96c6\u843d\u523a\u6fc0\u56e0\u5b50-1(CSF-1\uff0c\u4e5f\u79f0\u4e3aM-CSF)\/CSF1R\u8f74\uff0c\u8fd9\u662f\u5de8\u566c\u7ec6\u80de\u5206\u5316\u548c\u5b58\u6d3b\u7684\u91cd\u8981\u914d\u4f53-\u53d7\u4f53\u8f74\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u6291\u5236CCL5\u8f74\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u51cf\u5c11\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\uff0cIL-8(\u4e5f\u79f0\u4e3aCXCL8)\u80fd\u5c06\u9ad3\u7cfb\u7ec6\u80de\u62db\u52df\u5230\u80bf\u7624\u4e2d\uff0c\u6291\u5236\u5176\u901a\u8fc7CXCR2\u7684\u4fe1\u53f7\u4f20\u9012\u53ef\u4ee5\u51cf\u5c11TAM\u7684\u8f6c\u8fd0\u3002\u800c\u4e14\uff0c\u901a\u8fc7CXCR4\u4f20\u9012\u4fe1\u53f7\u7684\u8840\u7ba1\u751f\u6210\u548c\u8d8b\u5316\u56e0\u5b50CXCL12(\u4e5f\u79f0\u4e3aSDF-1\u03b1)\u53ef\u4ee5\u9776\u5411\u51cf\u5c11TAM\u7684\u6d78\u6da6\u3002<\/span><\/section>\n

\u00a0<\/span><\/p>\n

\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u5e94\u7528<\/span><\/strong><\/p>\n

\u00a0<\/span><\/p>\n

\u572820\u4e16\u7eaa80\u5e74\u4ee3\u672b\uff0c\u79d1\u5b66\u5bb6\u9996\u6b21\u4f7f\u7528\u4f53\u5916\u57f9\u517b\u5de8\u566c\u7ec6\u80de\u6cbb\u7597\u4e8615\u540d\u665a\u671f\u764c\u75c7\u60a3\u8005\u3002\u90e8\u5206\u60a3\u8005\u5728\u6cbb\u7597\u540e\u76846\u4e2a\u6708\u5185\u75c5\u60c5\u7a33\u5b9a\uff0c\u5728\u63a5\u53d7\u8179\u8154\u5de8\u566c\u7ec6\u80de\u6cbb\u7597\u76847\u4f8b\u8179\u819c\u764c\u60a3\u8005\u4e2d\uff0c2\u4f8b\u8179\u6c34\u6d88\u5931\u300215\u4f8b\u60a3\u8005\u4e2d\u67097\u4f8b\u8840\u6e05IL6\u5347\u9ad8\uff0c\u63d0\u793a\u8bf1\u5bfc\u4e86\u708e\u75c7\u53cd\u5e94\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u4e4b\u540e\u7684\u7814\u7a76\u66f4\u503e\u5411\u4e8e\u4f7f\u7528\u5e72\u6270\u7d20\u6fc0\u6d3b\u7684\u5de8\u566c\u7ec6\u80de\uff0c\u79f0\u4e3a\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u7684\u6740\u4f24\u7ec6\u80de\uff0c\u5728\u4f53\u5916\u548c\u4e34\u5e8a\u6a21\u578b\u4e2d\u5747\u663e\u793a\u4e86\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u5242\u91cf\u9012\u589e\u7814\u7a76\u663e\u793a\u6ce8\u5c04M1\u5de8\u566c\u7ec6\u80de\u6700\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u662f\u4f4e\u70e7\u548c\u6ce8\u5c04\u90e8\u4f4d\u7684\u4e0d\u9002\uff0c\u5c1a\u672a\u51fa\u73b0\u660e\u663e\u6bd2\u6027\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u7531\u4e8e\u5de8\u566c\u7ec6\u80de\u6781\u5316\u662f\u54cd\u5e94\u5916\u90e8\u7ebf\u7d22\u800c\u53d8\u5316\u7684\u8fde\u7eed\u4f53\uff0cTME\u53ef\u80fd\u5c06\u8fc7\u7ee7\u8f6c\u79fb\u7684\u5de8\u566c\u7ec6\u80de\u4eceIFN\u5f15\u53d1\u7684M1\u8868\u578b\u8f6c\u53d8\u4e3aM2 TAM\u8868\u578b\u3002<\/span><\/section>\n
\u00a0<\/span><\/section>\n
\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u5de8\u566c\u7ec6\u80de(CAR-M)\u7ec6\u80de\u6cbb\u7597\u764c\u75c7<\/span><\/strong>\uff1a<\/span><\/section>\n

\u00a0<\/span><\/p>\n

CAR-M<\/span>\u7597\u6cd5\u7684\u591a\u6548\u6297\u80bf\u7624\u673a\u5236\uff08\u4e0b\u56fe\uff09<\/span><\/p>\n

<\/p>\n

\u2460CAR-M\u5229\u7528\u9aa8\u9ad3\u7ec6\u80de\u7684\u5929\u7136\u80bf\u7624\u5f52\u5de2\u80fd\u529b\u8fdb\u5165\u5b9e\u4f53\u7624\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u2461\u4e00\u65e6\u8fdb\u5165\u80bf\u7624\uff0cCAR-M\u901a\u8fc7\u541e\u566c\u548c\u5206\u6ccc\u7ec6\u80de\u6bd2\u56e0\u5b50\u76f4\u63a5\u6740\u6b7b\u8868\u8fbe\u6297\u539f\u7684\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u2462\u9274\u4e8e\u5176M1\u8868\u578b\uff0cCAR-M\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\uff0c\u4fc3\u8fdb\u4fc3\u708e\u73af\u5883\u5e76\u5bfc\u81f4T\u7ec6\u80de\u548c\u5176\u4ed6\u767d\u7ec6\u80de\u7684\u52df\u96c6\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u2463\u5f53\u7528Ad5f35\u8f6c\u5bfc\u65f6\uff0cCAR-M\u62b5\u6297\u514d\u75ab\u6291\u5236\u6027TME\u3002\u6700\u540e\uff0cCAR-M\u4f5c\u4e3aT\u7ec6\u80de\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u53ef\u4ee5\u8bf1\u5bfc\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u5c0f\u7ed3\uff1a<\/span><\/strong><\/p>\n

\u5de8\u566c\u7ec6\u80de\u662f\u4e00\u79cd\u91cd\u8981\u7684\u6297\u80bf\u7624\u6548\u5e94\u7ec6\u80de\uff0c\u53ef\u4ee5\u76f4\u63a5\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u6216\u8005\u901a\u8fc7\u5448\u9012\u80bf\u7624\u76f8\u5173\u6297\u539f\u8bf1\u5bfc\u673a\u4f53\u514d\u75ab\u5e94\u7b54\u4ece\u800c\u6e05\u9664\u80bf\u7624\u3002<\/span><\/section>\n
\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAMs\uff09\u662f\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6570\u91cf\u6700\u591a\u7684\u708e\u75c7\u7ec6\u80de\u7fa4\uff0c\u5e7f\u6cdb\u5206\u5e03\u4e8e\u4e0a\u76ae\u7ec4\u7ec7\uff0c\u5982\u5927\u80a0\u3001\u80c3\u7b49\u7ec4\u7ec7\u7684\u514d\u75ab\u73af\u5883\u4e2d\uff0c\u4e0e\u4e73\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u7b49\u591a\u79cd\u5e38\u89c1\u80bf\u7624\u75be\u75c5\u5173\u7cfb\u5bc6\u5207\u3002TAMs\u5206\u4e3a2\u79cd\u8868\u578b\uff0c\u5176\u4e2dM2\u578bTAMs\u4e3a\u4fc3\u7624\u8868\u578b\uff0c\u901a\u8fc7\u514d\u75ab\u9003\u9038\u3001\u4fc3\u8840\u7ba1\u65b0\u751f\u7b49\u65b9\u5f0f\uff0c\u5f71\u54cd\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u5168\u8fc7\u7a0b\uff0c\u4fc3\u8fdb\u80bf\u7624\u8010\u836f\u3002<\/span><\/section>\n
\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u6280\u672f\u53ef\u4e0d\u53d7\u5206\u5b50\u9650\u5236\u9776\u5411\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u5176\u5e94\u7528\u4e8e\u5de8\u566c\u7ec6\u80de\u80fd\u591f\u4fc3\u8fdb\u5de8\u566c\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u6740\u4f24<\/span>\u4f5c\u7528\u3002<\/span><\/strong><\/section>\n

\u2014 THE \u00a0END \u2014<\/span><\/p>\n

\n

\u6765\u6e90\u00a0| \u751f\u4fe1\u5c0f\u8bfe\u5802\u00a0<\/span><\/section>\n
\u00a0<\/span><\/section>\n

\u2589\u00a0\u00a0\u5f80\u671f\u6587\u7ae0\u76ee\u5f55<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c25\u7ae0\uff1a\u611f\u67d3\u548c\u75ab\u82d7<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c24\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c23\u7ae0\uff1a\u708e\u75c7\u4e0e\u514d\u75ab<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c22\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u529f\u80fd<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c21\u7ae0\uff1a\u541e\u566c\u7ec6\u80de<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c20\u7ae0\uff1a\u56fa\u6709\u514d\u75ab\u7684\u9632\u5fa1\u4f5c\u7528<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c19\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u751f\u7406\u529f\u80fd\u7b80\u8ff0<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c17\u7ae0\uff1a\u514d\u75ab\u8bb0\u5fc6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7a33\u6001<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c16\u7ae0\uff1aT\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
<\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c4\u7ae0\uff1a\u80bf\u7624\u4e2d\u7684\u7a81\u53d8\u8868\u4f4d\uff08\u4e0b\uff09<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c4\u7ae0\uff1a\u80bf\u7624\u4e2d\u7684\u7a81\u53d8\u8868\u4f4d\uff08\u4e0a\uff09<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c3\u7ae0\uff1aCD8+ T\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u548c\u5316\u7597\u4e2d\u7684\u4f5c\u7528\uff08\u4e0b\uff09<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c3\u7ae0\uff1aCD8+ T\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u548c\u5316\u7597\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0b\uff09<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0a\uff09<\/a>
<\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c1\u7ae0\uff1a\u80bf\u7624\u514d\u75ab\u7b80\u53f2<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217\u66f4\u65b0\u9884\u544a<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

Linux\u6700\u5f3a\u603b\u7ed3\uff01<\/span><\/a><\/p>\n

TCGA\u514d\u75ab\u6d78\u6da6\u8bc4\u4ef7\u6570\u636e\u5e93<\/a><\/p>\n

ggplot2|\u8be6\u89e3\u516b\u5927\u57fa\u672c\u7ed8\u56fe\u8981\u7d20<\/a><\/p>\n

Python\u96c6\u6210\u5f00\u53d1\u73af\u5883PyCharm\u7684\u5b89\u88c5\u4e0e\u6fc0\u6d3b<\/a><\/p>\n

Python\u53d1\u884c\u7248Anaconda\u7684\u5b89\u88c5\u4e0e\u4f7f\u7528<\/a><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/p>\n

\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/p>\n

WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

QPCR\u5b9e\u9a8c\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/p>\n

\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/p>\n

\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/p>\n

IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/p>\n

BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a><\/p>\n

\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a><\/p>\n

HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a><\/p>\n

PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/p>\n

\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a><\/p>\n

\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a><\/p>\n

Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a><\/p>\n

\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a><\/p>\n

PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a><\/p>\n

\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a><\/span><\/p>\n

\u4e2d\u533b\u4e2d\u836f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u516b\u6bb5\u9526\uff08\u89c6\u9891\u7248+\u56fe\u7247\u7248\uff0c\u63a8\u8350\u6536\u85cf\uff09<\/span><\/a><\/p>\n

\u4e2d\u6210\u836f\u4f20\u7edf\u65b9\u5242\u4ea4\u53c9\u68c0\u7d22\u6570\u636e\u5e93\u4f7f\u7528\u8bf4\u660e<\/a><\/span><\/p>\n

\n

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