{"id":4351,"date":"2022-05-02T20:29:25","date_gmt":"2022-05-02T12:29:25","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2022\/05\/02\/%e6%9c%80%e6%96%b0%e8%82%bf%e7%98%a4%e7%a0%94%e7%a9%b6%e5%bf%85%e8%af%bb%e7%bb%bc%e8%bf%b0-hallmarks-of-cancer-cancer-discovery\/"},"modified":"2022-05-02T20:29:25","modified_gmt":"2022-05-02T12:29:25","slug":"%e6%9c%80%e6%96%b0%e8%82%bf%e7%98%a4%e7%a0%94%e7%a9%b6%e5%bf%85%e8%af%bb%e7%bb%bc%e8%bf%b0-hallmarks-of-cancer-cancer-discovery","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2022\/05\/02\/%e6%9c%80%e6%96%b0%e8%82%bf%e7%98%a4%e7%a0%94%e7%a9%b6%e5%bf%85%e8%af%bb%e7%bb%bc%e8%bf%b0-hallmarks-of-cancer-cancer-discovery\/","title":{"rendered":"\u6700\u65b0\u80bf\u7624\u7814\u7a76\u5fc5\u8bfb\u7efc\u8ff0: Hallmarks of Cancer-Cancer Discovery"},"content":{"rendered":"
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\u672c\u6587\u4f5c\u8005\u662f\u662f\u6765\u81ea\u745e\u58ebAgora\u8f6c\u5316\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684Douglas Hanahan\u6559\u6388<\/strong>\uff0cHanahan\u6559\u6388\u5728\u6b64\u524d\u7248\u672c\uff082011\u5e74\u7248\uff09\u7684\u57fa\u7840\u4e0a\u5f15\u5165\u4e864\u4e2a<\/span>\u65b0\u7684\u764c\u75c7\u6807\u5fd7\u6027\u7279\u5f81<\/strong><\/span>\uff0c\u7528\u4ee5\u89e3\u91ca\u6076\u6027\u80bf\u7624\u53d1\u751f\u3001\u53d1\u5c55\u3001\u6cbb\u7597\u54cd\u5e94\u7279\u6027\u7684\u673a\u5236\u3002<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u56fd\u9645\u9876\u7ea7\u520a\u7269Cancer Discovery<\/strong><\/span>\uff08IF=39\uff09<\/span>2022\u5e741\u6708\u520a\u7684\u5c01\u9762\u662f\u4e00\u4e2a\u201c\u91d1\u8272\u6307\u73af\u201d\uff0c\u6307\u73af\u4fa7\u9762\u9576\u5d4c\u7684\u662f\u80bf\u7624\u5b66\u754c\u7ecf\u5178\u7efc\u8ff0\u7cfb\u5217\u201c<\/span>Hallmarks of Cancer<\/strong><\/span>\u201d<\/strong><\/span><\/span>\uff08\u764c\u75c7\u7684\u7279\u5f81\uff09<\/span>\u6700\u65b0\u7248\u603b\u7ed3\u7684<\/strong><\/span>14\u5927\u764c\u75c7\u6807\u5fd7\u6027\u7279\u5f81<\/strong><\/span>\u3002<\/strong><\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u56fe\u7247\u6765\u81eaCancer Discovery<\/em><\/span><\/strong><\/span><\/p>\n

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\u6700\u65b0\u7248\u7684\u201cHallmarks of Cancer\u201d\u5df2\u7ecf\u662fDouglas Hanahan\u6559\u6388(\u53c2\u4e0e)<\/span>\u64b0\u5199\u7684\u7b2c\u4e09\u4e2a\u7248\u672c\u30022000\u5e74\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7684Robert A. Weinberg\u6559\u6388\u548cDouglas Hanahan\u6559\u6388\u5171\u540c\u5728Cell \u6742\u5fd7<\/strong>\u4e0a\u53d1\u8868\u4e86\u7b2c\u4e00\u7248\u201cThe Hallmarks of Cancer\u201d\u3002\u6587\u7ae0\u95ee\u4e16\u540e\uff0c\u4e00\u65f6\u6d1b\u9633\u7eb8\u8d35\uff0c\u7acb\u523b\u6210\u4e3a\u9886\u57df\u5185\u7684\u7ecf\u5178\u7efc\u8ff0<\/span><\/strong>\uff0c\u540e\u6765\u66f4\u662f\u6210\u4e3aCell \u6742\u5fd7\u5386\u53f2\u4e0a\u88ab\u5f15\u7528\u6b21\u6570\u6700\u591a\u7684\u7efc\u8ff0\u4e4b\u4e00<\/strong>\uff08\u76ee\u524d\u5df2\u7ecf\u8d85\u8fc737000\u6b21\uff09<\/span>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5341\u5e74\u4e4b\u540e\u76842011\u5e74\uff0c\u4e24\u4f4d\u6559\u6388\u6839\u636e\u5341\u5e74\u95f4\u5bf9\u80bf\u7624\u7814\u7a76\u7684\u6700\u65b0\u8fdb\u5c55\u548c\u7814\u7a76\u8303\u5f0f\u7684\u66f4\u8fed\uff0c\u4e0e\u65f6\u4ff1\u8fdb\u5730\u5bf9\u539f\u6765\u76846\u5927\u764c\u75c7\u6807\u5fd7\u6027\u7279\u5f81<\/strong>\u8fdb\u884c\u4e86\u66f4\u65b0\u548c\u62d3\u5c55\uff0c\u64b0\u5199\u7684\u201cHallmarks of cancer: the next generation<\/strong>\u201d\u4ecd\u65e7\u53d1\u8868\u5728Cell <\/strong><\/em>\u6742\u5fd7\u4e0a\uff0c\u76ee\u524d\u5df2\u88ab\u5f15\u7528\u8d85\u8fc757000\u6b21\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5341\u5e74\u5982\u70df\uff0c\u8f6c\u77ac\u5373\u901d\uff0c\u5982\u4eca2022\u5e74\u7684\u7b2c\u4e09\u7248\u201cHallmarks of Cancer\u201d\u6b63\u5f0f\u53d1\u5e03\uff0c\u800c\u4f5c\u8005\u53ea\u5269\u4e0b\u5176\u4e2d\u4e00\u4f4d<\/strong>\u3002\u516c\u5f00\u8d44\u6599\u663e\u793a\uff0cRobert A. Weinberg\u6559\u6388\uff081942~\uff09<\/span>\u4eca\u5e74\u5c06\u5c4a\u516b\u5341\u9ad8\u5bff\uff0c\u800cHanahan\u6559\u6388\uff081951~\uff09<\/span>\u4e5f\u5df2\u8fc7\u53e4\u7a00\u4e4b\u5e74\u3002\u60df\u613f\u795d\u613f\u4e24\u4f4d\u6559\u6388\u5065\u5eb7\u957f\u5bff\uff0c\u6211\u4eec\u4e5f\u66f4\u9700\u73cd\u60dc\u8fd9\u201c\u5341\u5e74\u51dd\u4e00\u7bc7\u201d\u7684\u4f73\u4f5c<\/span><\/strong>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5728\u6b64\uff0c\u5c0f\u7f16\u5c06\u5c3d\u529b\u68b3\u7406\u8fd9\u7bc7\u7ecf\u5178\u7efc\u8ff0\u7684\u6838\u5fc3\u5185\u5bb9\uff0c\u4ee5\u4f5c\u629b\u7816\u5f15\u7389\u4e4b\u7528\uff0c\u8ba9\u66f4\u591a\u8bfb\u8005\u901a\u8fc7\u201cThe hallmarks of cancer\u201d\u8ba4\u8bc6\u764c\u75c7\u5e76\u5bf9\u80bf\u7624\u751f\u7269\u5b66\u4ea7\u751f\u5174\u8da3<\/span><\/strong>\u3002\u53e6\u5916\uff0c\u8d44\u6df1\u8bfb\u8005\u6216\u611f\u5174\u8da3\u7684\u521d\u5b66\u8005\u53ef\u4ee5\u5728\u6587\u672b\u627e\u5230\u4e09\u4e2a\u7248\u672c\u7684PDF\u6587\u4ef6\u4e0b\u8f7d\u94fe\u63a5\u3002\u5c0f\u7f16\u89e3\u8bfb\u53ef\u80fd\u591a\u6709\u4e0d\u5f53\u4e4b\u5904\uff0c\u5982\u6709\u9700\u8981\u8fd8\u8bf7\u9605\u8bfb\u539f\u6587<\/strong>\u3002
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\u8fd9\u6b21Hallmarks of Cancer\u7684\u66f4\u65b0\u66f4\u662f\u5f15\u7206Twitter\u5237\u5c4f<\/strong>\uff0c\u5927\u91cf\u80bf\u7624\u7814\u7a76\u4e13\u5bb6\u8f6c\u53d1\u63a8\u8350\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u745e\u58eb\u6d1b\u6851\u5927\u5b66\u6559\u6388\u3001\u764c\u75c7\u7814\u7a76\u9886\u57df\u7684\u77e5\u540d\u4e13\u5bb6Johanna Joyce\u503e\u60c5\u63a8\u8350\uff01<\/span><\/p>\n


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\u201c\u764c\u75c7\u76846\u5927\u6807\u5fd7\u6027\u7279\u5f81<\/strong><\/span>\u201d\u5145\u5206\u68b3\u7406\u51dd\u7ec3\u4e86\u8fc7\u53bb\u8fd1\u767e\u5e74\u7684\u80bf\u7624\u7814\u7a76\u8fdb\u5c55\u548c\u53d1\u73b0\uff0c\u4e3a\u7406\u89e3\u764c\u75c7\u7684\u591a\u6837\u5316\u8868\u578b\u642d\u5efa\u4e86\u4e00\u4e2a\u57fa\u7840\u903b\u8f91\u6846\u67b6\u3002\u80bf\u7624\u7684\u53d1\u751f\u53d1\u5c55\u662f\u6e10\u8fdb\u5316\u3001\u591a\u6b65\u9aa4\u7684\uff0c\u5728\u6b63\u5e38\u7ec6\u80de\u8f6c\u53d8\u4e3a\u80bf\u7624\u7ec6\u80de\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5b83\u4eec\u4f1a\u9010\u6b65\u83b7\u5f97\u8fd9\u4e9b\u6807\u5fd7\u6027\u529f\u80fd\uff0c\u5e76\u6700\u7ec8\u6f14\u53d8\u6210\u6076\u6027\u75c5\u53d8\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1\u3001\u81ea\u7ed9\u81ea\u8db3\u7684\u751f\u957f\u4fe1\u53f7<\/strong>\uff08self-sufficiency in growth signals\uff09<\/span>\uff1a\u5982H-RAS\u81f4\u764c\u57fa\u56e0\u7684\u6fc0\u6d3b\u3002
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2\u3001\u5bf9\u751f\u957f\u6291\u5236\u4fe1\u53f7\u4e0d\u654f\u611f<\/strong>\uff08insensitivity to anti-growth signals\uff09<\/span>\uff1a\u5982\u89c6\u7f51\u819c\u6bcd\u7ec6\u80de\u7624\uff08Rb\uff09<\/span>\u57fa\u56e0\uff08\u80bf\u7624\u6291\u5236\u57fa\u56e0\uff09<\/span>\u7684\u7f3a\u5931\u3002<\/span><\/section>\n
3\u3001\u9003\u907f\u51cb\u4ea1<\/strong>\uff08evading apoptosis\uff09<\/span>\uff1a\u5982\u751f\u6210IGF\u56e0\u5b50\u3002<\/span><\/section>\n
4\u3001\u65e0\u9650\u590d\u5236\u7684\u6f5c\u529b<\/strong>\uff08limitless replicative potential\uff09<\/span>\uff1a\u5982\u6fc0\u6d3b\u7aef\u7c92\u9176\u3002<\/span><\/section>\n
5\u3001\u6301\u7eed\u7684\u8840\u7ba1\u751f\u6210<\/strong>\uff08sustained angiogenesis\uff09<\/span>\uff1a\u5982\u751f\u6210VEGF\u8bf1\u5bfc\u7269\u3002<\/span><\/section>\n
6\u3001\u7ec4\u7ec7\u4fb5\u88ad\u548c\u8f6c\u79fb<\/strong>\uff08tissue invasion & metastasis\uff09<\/span>\uff1a\u5982E-\u9499\u9ecf\u86cb\u767d\u7684\u5931\u6d3b\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u8fd9\u4e00\u7248\u5728\u539f\u6709\u76846\u5927\u6807\u5fd7\u6027\u7279\u5f81\u7684\u57fa\u7840\u4e0a<\/span>\u589e\u52a0\u4e864\u4e2a\u65b0\u7684\u6807\u5fd7\u6027\u7279\u5f81<\/strong><\/span>\uff0c\u5206\u522b\u662f\uff1a\u7ec6\u80de\u80fd\u91cf\u4ee3\u8c22\u7684\u5931\u63a7<\/strong><\/span>\uff08deregulating cellular energetics\uff09<\/span>\uff0c\u9003\u907f\u514d\u75ab\u6e05\u9664<\/strong><\/span>\uff08avoiding immune destruction\uff09<\/span>\uff0c\u80bf\u7624\u4fc3\u708e\u75c7\u4f5c\u7528<\/strong><\/span>\uff08tumor-promoting inflammation\uff09<\/span>\uff0c\u57fa\u56e0\u7ec4\u7684\u4e0d\u7a33\u5b9a\u6027\u548c\u7a81\u53d8<\/strong><\/span>\uff08genome instability and mutation\uff09<\/span>\uff0c\u5e76\u5c06\u539f\u6709\u76846\u5927\u6807\u5fd7\u6027\u7279\u5f81\u6982\u5ff5\u7684\u5185\u6db5\u548c\u5916\u5ef6\u8fdb\u884c\u4e86\u4e00\u4e9b\u8c03\u6574\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u65b0\u589e\u52a0\u7684<\/span>4\u5927\u6807\u5fd7\u6027\u7279\u5f81<\/span><\/strong>\u8003\u8651\u4e86\u80bf\u7624\u4ee3\u8c22\u3001\u80bf\u7624\u514d\u75ab\u4ee5\u53ca\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u5728\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u30024\u4e2a\u65b0\u589e\u6807\u5fd7\u4e2d\uff0c\u524d\u4e24\u4e2a<\/strong>\u88ab\u5b9a\u4e49\u4e3a\u201c\u521d\u73b0\u6807\u5fd7<\/strong>\u201d<\/span>\uff08emerging hallmarks\uff09<\/span>\uff0c\u56e0\u4e3a\u4e24\u8005\u7684\u4f5c\u7528\u8fd8\u672a\u5f97\u5230\u5168\u9762\u7684\u9a8c\u8bc1\uff1b\u800c\u540e\u4e24\u8005<\/strong>\u88ab\u5b9a\u4e49\u4e3a\u201c\u8d4b\u80fd\u7279\u5f81<\/strong>\u201d<\/span>\uff08enabling characteristics\uff09<\/span>\uff0c\u56e0\u4e3a\u6b63\u662f\u5b83\u4eec\u5bfc\u81f4\u4e86<\/span>\u80bf\u7624\u5f02\u5e38\u72b6\u6001\u7684\u540e\u679c<\/span><\/strong>\uff08consequences\uff09<\/span>\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u660e\u786e\u4e86\u4e00\u4e2a\u89c2\u70b9\uff0c\u5373\u80bf\u7624\u7684\u53d1\u5c55\u4e0d\u4ec5\u662f\u80bf\u7624\u7ec6\u80de\u6570\u91cf\u7684\u589e\u52a0\uff0c\u4e5f\u9700\u8981\u56f4\u7ed5\u201c<\/span>\u80bf\u7624\u5fae\u73af\u5883<\/strong><\/span>\u201d\u8fdb\u884c\u7406\u89e3\u3002
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1\u3001\u201c\u6301\u7eed\u589e\u6b96\u4fe1\u53f7\u201d vs \u201cEGFR\u6291\u5236\u5242\u201d\uff1b
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2\u3001\u201c\u9003\u907f\u751f\u957f\u6291\u5236\u201d vs \u201c\u7ec6\u80de\u5468\u671f\u4f9d\u8d56\u6027\u6fc0\u9176<\/span>\uff08CDK\uff09<\/span>\u6291\u5236\u5242\u201d\uff1b<\/span><\/section>\n
3\u3001\u201c\u9003\u907f\u514d\u75ab\u6e05\u9664\u201d vs \u201c\u6fc0\u6d3b\u514d\u75ab\u7684\u6297CTLA-4\u5355\u514b\u9686\u6297\u4f53\u201d\uff1b<\/span><\/section>\n
4\u3001\u201c\u65e0\u9650\u590d\u5236\u7684\u80fd\u529b\u201d vs \u201c\u7aef\u7c92\u672b\u7aef\u8f6c\u79fb\u9176\u6291\u5236\u5242\u201d\uff1b<\/span><\/section>\n
5\u3001\u201c\u80bf\u7624\u4fc3\u708e\u75c7\u4f5c\u7528\u201d vs \u201c\u9009\u62e9\u6027\u6297\u708e\u836f\u7269\u201d\uff1b<\/span><\/section>\n
6\u3001\u201c\u6fc0\u6d3b\u6d78\u6da6\u548c\u8f6c\u79fb\u201d vs \u201cHGF\/c-Met\u6291\u5236\u5242\u201d\uff1b<\/span><\/section>\n
7\u3001\u201c\u4fc3\u8840\u7ba1\u751f\u6210\u201d vs \u201cVEGF\u6291\u5236\u5242\u201d\uff1b<\/span><\/section>\n
8\u3001\u201c\u57fa\u56e0\u7ec4\u7684\u4e0d\u7a33\u5b9a\u548c\u7a81\u53d8\u201d vs \u201cPARP\u6291\u5236\u5242\u201d\uff1b<\/span><\/section>\n
9\u3001\u201c\u62b5\u6297\u7ec6\u80de\u6b7b\u4ea1\u201d vs \u201c\u8bf1\u5bfc\u51cb\u4ea1\u7684BH3\u7c7b\u4f3c\u7269\u201d\uff1b<\/span><\/section>\n
10\u3001\u201c\u7ec6\u80de\u80fd\u91cf\u4ee3\u8c22\u7684\u5931\u63a7\u201d vs \u201c\u6709\u6c27\u7cd6\u9175\u89e3\u6291\u5236\u5242\u201d\uff1b<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7b2c\u4e09\u7248\uff082022\u5e74\uff09\uff1a<\/span><\/strong><\/span>\u764c\u75c7\u768414\u5927\u6807\u5fd7\u6027\u7279\u5f81 <\/span><\/strong><\/span><\/p>\n


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\u5728\u65e2\u6709\u768410\u5927\u6807\u5fd7\u6027\u7279\u5f81\u7684\u57fa\u7840\u4e0a\uff0c\u672c\u6587\u4f5c\u8005\u6b64\u6b21\u518d\u5ea6\u589e\u52a0\u4e864\u4e2a\u7279\u5f81\uff0c\u5206\u522b\u662f\uff1a\u89e3\u9501\u8868\u578b\u53ef\u5851\u6027<\/strong><\/span>\uff08Unlocking phenotypic plasticity\uff09<\/span>\u3001\u975e\u7a81\u53d8\u8868\u89c2\u9057\u4f20\u91cd\u7f16\u7a0b<\/strong><\/span>\uff08Non-mutational epigenetic reprogramming\uff09<\/span>\u3001\u591a\u6001\u6027\u7684\u5fae\u751f\u7269\u7ec4<\/strong><\/span>\uff08Polymorphic microbiomes\uff09<\/span>\u548c\u8870\u8001\u7ec6\u80de<\/strong><\/span>\uff08Senescent cells\uff09<\/span>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u65b0\u589e\u76844\u5927\u6807\u5fd7\u6027\u7279\u5f81\u5177\u4f53\u5185\u5bb9\u5982\u4e0b<\/span><\/strong>\uff1a<\/span><\/p>\n


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1\u3001<\/span>\u89e3\u9501\u8868\u578b\u53ef\u5851\u6027<\/span><\/strong>\uff08Unlocking phenotypic plasticity\uff09<\/span>\uff0c\u800c\u8868\u578b\u53ef\u5851\u6027\u53ef\u4ee5\u7834\u574f\u7ec6\u80de\u5206\u5316\uff0c\u4f5c\u8005\u5c06\u5176\u5206\u4e3a\u4e09\u4e2a\u65b9\u9762\uff0c\u7ec6\u80de\u53bb\u5206\u5316<\/span>\uff08Dedifferentiation\uff09<\/span>\u3001\u7ec6\u80de\u5206\u5316\u4e2d\u65ad<\/span>\uff08Blocked Differentiation\uff09<\/span>\u548c\u7ec6\u80de\u8f6c\u5206\u5316<\/span>\uff08Transdifferentiation\uff09<\/span>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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2\u3001<\/strong><\/span>\u975e\u7a81\u53d8\u8868\u89c2\u9057\u4f20\u91cd\u7f16\u7a0b<\/strong><\/span>\uff08non-mutational epigenetic reprogramming\uff09<\/span>\uff1a\u8868\u89c2\u9057\u4f20\u5373DNA\u5e8f\u5217\u6ca1\u6709\u53d1\u751f\u53d8\u5316\uff0c\u4f46\u57fa\u56e0\u529f\u80fd\u53d1\u751f\u4e86\u53ef\u9057\u4f20\u7684\u53d8\u5316\u3002\u4e5f\u5305\u62ec\u4e09\u4e2a\u65b9\u9762\uff1a\u8bf1\u5bfc\u8868\u89c2\u91cd\u7f16\u7a0b\u7684\u73af\u5883\u673a\u5236<\/strong><\/span>\uff08Microenironmental Mechanisms of Epigenetic Reprograming\uff09<\/span>\u3001\u8868\u89c2\u8c03\u8282\u5f02\u8d28<\/strong>\u6027<\/strong><\/span>\uff08Epigenetic Regulatory Heterogeneity\uff09<\/span>\u548c\u80bf\u7624\u5fae\u73af\u5883\u57fa\u8d28\u7ec6\u80de\u7684\u8868\u89c2\u8c03\u63a7<\/strong><\/span>\uff08Epigenetic regulation of the stromal cell types populating the tumor microenvironment\uff09<\/span>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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3\u3001<\/strong><\/span>\u591a\u6001\u6027\u7684\u5fae\u751f\u7269\u7ec4<\/strong><\/span>\uff08Polymorphic microbiomes\uff09<\/span>\uff0c\u5927\u91cf\u5b58\u5728\u4e8e\u7ed3\u80a0\u3001\u5176\u4ed6\u9ecf\u819c\u53ca\u5176\u8fde\u63a5\u90e8\u4f4d\uff0c\u6216\u80bf\u7624\u5185\u90e8\u7684\u5fae\u751f\u7269\u7fa4\u843d\u6784\u6210\u80bf\u7624\u7684\u5fae\u751f\u7269\u7ec4\u3002\u80bf\u7624\u5fae\u751f\u7269\u7ec4\u5177\u6709\u6781\u9ad8\u7684\u591a\u6001\u6027\uff0c\u5bf9\u4e8e\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u548c\u6cbb\u7597\u54cd\u5e94\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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4\u3001<\/strong>\u8870\u8001\u7ec6\u80de<\/strong><\/span>\uff08Senescent cells\uff09<\/span>\uff1a<\/strong>\u7ec6\u80de\u8870\u8001\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u7ef4\u6301\u7ec4\u7ec7\u7a33\u6001\u7684\u4e00\u79cd\u4e0d\u53ef\u9006\u7684\u6291\u764c\u6027\u4fdd\u62a4\u673a\u5236\uff0c\u7136\u800c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u8870\u8001\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7\u8870\u8001\u76f8\u5173\u5206\u6ccc\u8868\u578b\uff08Senescence-associated secretory phenotype, SASP\uff09<\/span>\u7b49\u65b9\u5f0f\u4fc3\u8fdb\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\u3002\u4e0d\u8fc7\uff0c\u8870\u8001\u4f5c\u4e3a\u4e00\u4e2a\u80bf\u7624\u6807\u5fd7\u7684\u7814\u7a76\u4ecd\u5728\u8d77\u6b65\u9636\u6bb5\uff0c\u8fd8\u9700\u8fdb\u4e00\u6b65\u7684\u5e7f\u6cdb\u9a8c\u8bc1\u548c\u4e25\u8c28\u5ba1\u89c6\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u764c\u75c7\u7684\u6982\u5ff5\u5316\u3001\u6807\u5fd7\u5316\u6982\u62ec<\/span><\/strong>\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u5177\u6709\u542f\u53d1\u610f\u4e49\u7684\u5de5\u5177\uff0c\u6709\u5229\u4e8e\u5c06\u8de8\u8d8a\u764c\u75c7\u8868\u578b\u548c\u57fa\u56e0\u578b\u7684\u5de8\u5927\u590d\u6742\u6027\u51dd\u7ec3\u4e3a\u5305\u62ec\u51e0\u9879\u57fa\u672c\u539f\u5219\u7684\u4e00\u5957\u7b80\u6d01\u7406\u8bba\u3002\u968f\u7740\u5bf9\u764c\u75c7\u53d1\u751f\u3001\u53d1\u5c55\u673a\u5236\u7684\u8ba4\u8bc6\u4e0d\u65ad\u6df1\u5316<\/strong>\uff0c\u8fd9\u4e00\u590d\u6742\u75be\u75c5\u5728\u5176\u4ed6\u65b9\u9762\u7684\u591a\u79cd\u7279\u6027\u4e5f\u8868\u73b0\u51fa\u6982\u5ff5\u5316\u4e3a<\/span>\u6807\u5fd7\u6027\u7279\u5f81<\/span><\/strong>\u7684\u6f5c\u529b\u3002\u7c4d\u6b64\uff0c\u6211\u4eec\u65b0\u589e\u52a0\u7684\u51e0\u4e2a\u6807\u5fd7\u4e2d\uff0c\u8868\u578b\u53ef\u5851\u6027\u53ca\u5206\u5316\u4e2d\u65ad\u5171\u540c\u6784\u6210\u4e00\u4e2a\u72ec\u7acb\u7684\u6807\u5fd7\u6027\u7279\u5f81\uff0c\u800c\u975e\u7a81\u53d8\u6027\u7684\u8868\u89c2\u9057\u4f20\u91cd\u7f16\u7a0b\u548c\u591a\u6001\u5fae\u751f\u7269\u7fa4\u843d\u5747\u6784\u6210\u72ec\u7279\u7684\u3001\u6709\u52a9\u4e8e\u5176\u4ed6\u6807\u5fd7\u6027\u80fd\u529b\u83b7\u5f97\u7684\u8d4b\u80fd\u7279\u5f81<\/span>\uff08enabling characteristics\uff09<\/span>\u3002\u6b64\u5916\uff0c\u4e0d\u540c\u6765\u6e90\u7684\u8870\u8001\u7ec6\u80de\u4e5f\u53ef\u88ab\u89c6\u4e3a\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5177\u6709\u91cd\u8981\u529f\u80fd\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u56e0\u6b64\u4e5f\u88ab\u6211\u4eec\u6dfb\u52a0\u5230\u201c\u521d\u73b0\u7279\u5f81<\/strong>\u201d\u4e2d\u4ee5\u5f85\u672a\u6765\u8fdb\u4e00\u6b65\u7684\u8003\u5bdf\u3002
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\u764c\u75c7\u7684\u591a\u6837\u6027\u5177\u6709\u4ee4\u4eba\u751f\u754f\u7684\u5e7f\u5ea6\u548c\u8303\u56f4\uff0c\u5176\u591a\u6837\u6027\u8868\u73b0\u8de8\u8d8a\u4e86\u9057\u4f20\u5b66\u3001\u7ec6\u80de\u548c\u7ec4\u7ec7\u751f\u7269\u5b66\u3001\u75c5\u7406\u5b66\uff0c\u548c\u6cbb\u7597\u54cd\u5e94\u7279\u5f81\u3002\u4eba\u7c7b\u8d8a\u6765\u8d8a\u5f3a\u5927\u7684\u5b9e\u9a8c\u6280\u672f\u548c\u8ba1\u7b97\u5de5\u5177\u6b63\u5728\u5f62\u6210\u5173\u4e8e\u764c\u75c7\u6240\u5305\u542b\u7684\u5404\u79cd\u75be\u75c5\u7684\u591a\u79cd\u8868\u73b0\u5f62\u5f0f\u7684\u6d77\u91cf\u201c\u5927\u6570\u636e\u201d\u3002\u800c<\/span>\u764c\u75c7\u6807\u5fd7\u7684\u7efc\u5408\u5316\u6982\u5ff5<\/span><\/strong>\u6709\u52a9\u4e8e\u5c06\u8fd9\u79cd\u590d\u6742\u6027\u9010\u6b65\u63d0\u70bc\u4e3a\u4e00\u5957\u903b\u8f91\u5316\u7684\u79d1\u5b66\u7406\u8bba\u3002\u4ece\u8fd9\u4e2a\u89d2\u5ea6\u6765\u8bb2\uff0c\u6211\u4eec\u5728\u6b64\u63d0\u51fa\u7684\u65b0\u7ef4\u5ea6\u6216\u53ef\u8fdb\u4e00\u6b65\u589e\u52a0\u4e0a\u8ff0\u5de5\u4f5c\u7684\u4ef7\u503c\uff0c\u4ee5\u4fbf\u6211\u4eec\u66f4\u5145\u5206\u5730\u7406\u89e3\u764c\u75c7\u53d1\u751f\u548c\u6076\u6027\u53d1\u5c55\u7684\u673a\u5236\uff0c\u5e76\u5c06\u8fd9\u4e9b\u77e5\u8bc6\u5e94\u7528\u5230\u764c\u75c7\u6cbb\u7597\u4e2d<\/strong>\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

1\u3001Douglas Hanahan, Robert A. Weinberg. The Hallmarks of Cancer. Cell. 2000; 100(1): 57-70. <\/span><\/p>\n

2\u3001Douglas Hanahan, Robert A. Weinberg. Hallmarks of Cancer: The Next Generation. Cell. 2011; 144(5): 646-674. <\/span><\/p>\n

3\u3001Douglas Hanahan. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022; 12: 31-46. <\/span><\/p>\n


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\u2014 THE  END \u2014<\/span><\/p>\n

\u516c\u4f17\u53f7\u540e\u53f0\u56de\u590d220502\u53ef\u4e0b\u8f7d\u76f8\u5173PDF\u6587\u4ef6<\/span>
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\u6765\u6e90 | BioMedAdv<\/span><\/section>\n
\u6574\u7406 | \u9896\u6cfd\u65b0<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u533b\u836f\u901f\u89c8
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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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