{"id":4396,"date":"2022-05-04T00:00:00","date_gmt":"2022-05-03T16:00:00","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2022\/05\/04\/%e5%9f%ba%e4%ba%8e%e7%bb%86%e8%83%9e%e5%9f%ba%e5%9b%a0%e7%89%b9%e5%be%81%e8%bf%bd%e8%b8%aa%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e9%80%83%e9%80%b8\/"},"modified":"2022-05-04T00:00:00","modified_gmt":"2022-05-03T16:00:00","slug":"%e5%9f%ba%e4%ba%8e%e7%bb%86%e8%83%9e%e5%9f%ba%e5%9b%a0%e7%89%b9%e5%be%81%e8%bf%bd%e8%b8%aa%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e9%80%83%e9%80%b8","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2022\/05\/04\/%e5%9f%ba%e4%ba%8e%e7%bb%86%e8%83%9e%e5%9f%ba%e5%9b%a0%e7%89%b9%e5%be%81%e8%bf%bd%e8%b8%aa%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e9%80%83%e9%80%b8\/","title":{"rendered":"\u57fa\u4e8e\u7ec6\u80de\u57fa\u56e0\u7279\u5f81\u201c\u8ffd\u8e2a\u201d\u80bf\u7624\u514d\u75ab\u9003\u9038"},"content":{"rendered":"
\n
<\/mpprofile><\/section>\n
\u514d\u75ab\u9003\u907f\uff08immune evasion\uff09\u662f\u764c\u75c7\u53d1\u751f<\/strong>\u548c\u8f6c\u79fb<\/strong>\u7684\u5173\u952e\u3002\u8ffd\u8e2a\u514d\u75ab\u9003\u9038\u7684\u52a8\u6001\u8fc7\u7a0b<\/strong>\uff0c\u6709\u52a9\u4e8e\u9610\u8ff0\u5176\u5728\u6cbb\u7597\u5e72\u9884\u4e2d\u7684\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002<\/span>
<\/section>\n

<\/section>\n
\u514d\u75ab\u9003\u9038\u201c\u8ffd\u8e2a\u201d\u7814\u7a76<\/span><\/strong><\/span><\/section>\n

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\u6700\u8fd1\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66Duke\u8f6c\u5316\u514d\u75ab\u5b66\u7814\u7a76\u6240\u3001\u5357\u6d0b\u7406\u5de5\u5927\u5b66\u3001\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40(A*STAR)\u5206\u5b50\u7ec6\u80de\u7814\u7a76\u6240\u7b49\u5355\u4f4d\u7684\u79d1\u5b66\u5bb6\u505a\u4e86\u8fd9\u9879\u201c\u8ffd\u8e2a\u201d<\/strong>\u5de5\u4f5c\u3002\u4ed6\u4eec\u9009\u62e9\u4e86\u809d\u7ec6\u80de\u764c(Hepatocellular carcinoma \uff0cHCC)\uff0c\u5168\u7403\u7b2c\u56db\u5927\u5e38\u89c1\u764c\u75c7\u3002<\/span><\/section>\n

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<\/section>\n
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    \n
  • \n

    Treg\uff1aCD4+CD152+FoxP3+TIGIT
    <\/strong><\/p>\n<\/li>\n

  • \n

    Naive T\uff1aCD4+CD27+CD45RO-
    <\/strong><\/p>\n<\/li>\n

  • \n

    \u589e\u6b96T\u7ec6\u80de\uff1aCD3+Ki67+
    <\/strong><\/p>\n<\/li>\n

  • \n

    \u6fc0\u6d3bCD8+T\uff1aCD8+GB+PD-1-
    <\/strong><\/p>\n<\/li>\n

  • \n

    \u7ec4\u7ec7\u9a7b\u7559\u8bb0\u5fc6T\u7ec6\u80de\uff1aCD103+CD45RO+PD-1+<\/strong><\/p>\n<\/li>\n

  • \n

    \u8bb0\u5fc6CD4+T\u7ec6\u80de\uff1aPD1+ CD45RO+CD4+<\/strong><\/p>\n<\/li>\n

  • \n

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    <\/strong><\/p>\n<\/li>\n

  • \n

    NK\u7ec6\u80de\uff1aGB+CD56+<\/strong><\/p>\n<\/li>\n

  • \n

    \u9ad3\u7cfb\u7ec6\u80de\uff1aHLA-DR+CD14+<\/strong><\/p>\n<\/li>\n

  • \n

    B\u7ec6\u80de\uff1aHLA-DR+CD19+<\/strong><\/p>\n<\/li>\n<\/ul>\n


    <\/section>\n
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    <\/section>\n
    1. \u7b2c\u4e00\u6ce2\u514d\u75ab\u9003\u9038<\/span><\/strong>\u53d1\u751f\u5728\u80bf\u7624\u53d1\u751f\u7684\u65e9\u671f\u9636\u6bb5<\/strong>\uff0c\u9003\u79bb\u514d\u75ab\u76d1\u89c6\uff0c\u83b7\u5f97\u751f\u957f\u4f18\u52bf\uff0c\u539f\u53d1\u75c5\u7076\u8fc5\u901f\u589e\u5927\u3002<\/span><\/section>\n

    <\/section>\n

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    <\/section>\n
    2. <\/span><\/strong>\u672c\u6b21\u7814\u7a76\u8005\u53d1\u73b0\uff1a\u7b2c\u4e8c\u6ce2\u514d\u75ab\u9003\u9038<\/strong>\u548c\u540c\u65f6\u53d1\u751f\u7684\u80bf\u7624\u8fdb\u5c55\u5728II\u671f<\/strong>HCC\u8fbe\u5230\u9ad8\u5cf0\u3002<\/span><\/section>\n
    \u7279\u70b9<\/span><\/section>\n
    1\uff09\u7ec6\u80de\u7279\u5f81<\/span><\/strong><\/section>\n
      \n
    • \n

      \u8017\u7aedCD8+T\u7ec6\u80de\u548cTreg\u7684\u7ec6\u80de\u6570\u91cf\u8fbe\u5230\u201c\u9876\u5cf0\u201d<\/span><\/p>\n<\/li>\n

    • \n

      NK\u7ec6\u80de\u6570\u91cf\u3001\u6fc0\u6d3b\u7684CD8+T\u7ec6\u80de\u964d\u5230\u201c\u8c37\u5e95\u201d<\/span><\/p>\n<\/li>\n<\/ul>\n


      <\/section>\n

      <\/section>\n
      <\/span><\/section>\n
      <\/span><\/section>\n

      <\/section>\n
      2\uff09\u57fa\u56e0\u7279\u5f81<\/span><\/strong><\/section>\n
      RNA-seq\u7684\u7ed3\u679c<\/span><\/section>\n
        \n
      • \n

        S2\u671f\u867d\u7136\u6574\u4f53\u57fa\u56e0\u4e0a\u8c03\u6ca1\u6709\u53d8\u5316\uff0c\u4f46\u662f\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u4e0a\u8c03\u6bd4\u4f8b\u663e\u8457\u964d\u4f4e\uff0c\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u4e0b\u8c03\u5f00\u59cb\u589e\u52a0\uff0c\u5c24\u5176\u662f\u8d8b\u5316\u76f8\u5173\u57fa\u56e0\u3002
        <\/span><\/p>\n<\/li>\n

      • \n

        S3\u671f\uff0c\u57fa\u56e0\u5927\u591a\u5c5e\u4e8e\u4e0b\u8c03\u7684\u72b6\u6001\uff0c\u5176\u4e2d\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u4e0b\u8c03\u5c24\u5176\u663e\u8457\uff08TCR\u4fe1\u53f7\uff1bIFN-\u03b3\u3001TNF\u901a\u8def\uff1bT\u7ec6\u80de\u8d8b\u5316\u7b49\uff09\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n


        <\/p>\n


        <\/p>\n

        <\/p>\n

        <\/p>\n


        <\/p>\n

        3\uff09\u5173\u952e\u514d\u75ab\u5206\u5b50\u7279\u5f81<\/strong><\/span>
        <\/p>\n


        <\/p>\n

          \n
        • \n

          \u6297\u539f\u63d0\u5448\u5206\u5b50\u4e0b\u8c03\uff1aHLA-DQB1\uff0cHLA-DQB5
          <\/span><\/p>\n<\/li>\n

        • \n

          \u514d\u75ab\u5e94\u7b54\u76f8\u5173\u5206\u5b50\u4e0b\u8c03\uff1aCD40\uff0cTLR7\uff0cGATA3\uff0cIL-6
          <\/span><\/p>\n<\/li>\n

        • \n

          \u514d\u75ab\u8017\u7aed\u5206\u5b50\u4e0a\u8c03\uff1aLAG3\u3001CTLA-4\u3001PDCD1<\/span>
          <\/p>\n<\/li>\n<\/ul>\n


          <\/p>\n


          <\/p>\n

          <\/p>\n


          <\/p>\n

          \u7b80\u8bc4\uff1a<\/span><\/p>\n


          <\/p>\n

          \u80bf\u7624\u53d1\u751f\u3001\u8fdb\u5c55\u3001\u8f6c\u5f52\u662f\u80bf\u7624\u4e0e\u514d\u75ab\u7cfb\u7edf\u7684\u519b\u5907\u7ade\u8d5b\uff0c\u6b64\u6d88\u5f7c\u957f\u3002\u4e4b\u524d\u514d\u75ab\u7f16\u8f91\u7406\u8bba\uff0c\u5c06\u80bf\u7624\u8fdb\u5c55\u524d\u7684\u514d\u75ab\u5f52\u4e3a\u4e09\u4e2a\u9636\u6bb5\uff1a\u6e05\u9664\uff08elimination\uff09\u3001\u5e73\u8861\uff08equilibrium\uff09\u3001\u9003\u9038\uff08escape\uff09\u3002\u7b2c\u4e00\u6b21\u9003\u9038\u4ee5\u540e\uff0c\u80bf\u7624\u5f00\u59cb\u5feb\u901f\u6269\u589e\u3002<\/span><\/span><\/p>\n


          <\/section>\n

          <\/p>\n


          <\/p>\n

          \u7b2c\u4e8c\u6ce2\u514d\u75ab\u9003\u9038\u53d1\u751f\u5728\u80bf\u7624\u8fdb\u5c55\u7684\u4e2d\u671f\uff0c\u6548\u5e94\u514d\u75ab\u7ec6\u80de\u5f00\u59cb\u51fa\u73b0\u8017\u7aed\u8868\u578b\uff0c\u5e76\u4e14\u6297\u539f\u63d0\u5448\u5206\u5b50\u548c\u5e94\u7b54\u7684\u5171\u523a\u6fc0\u5206\u5b50\u7b49\u4e0b\u8c03\uff0c\u8d8b\u5316\u56e0\u5b50\u8868\u8fbe\u4e0b\u8c03\uff1b\u514d\u75ab\u6291\u5236\u7ec6\u80de\u5f00\u59cb\u589e\u52a0\u7b49\u3002\u4e3a\u80bf\u7624\u8f6c\u79fb\u505a\u597d\u94fa\u57ab\u3002\u56e0\u800c\u6b64\u671f\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u5f88\u5173\u952e\uff0c\u5bf9\u4e8e\u51cf\u5c11\u8f6c\u79fb\u7684\u53d1\u751f\uff0c\u83b7\u5f97\u826f\u597d\u7684\u4e34\u5e8a\u8f6c\u5f52\u663e\u5f97\u5f88\u5173\u952e\u3002<\/span><\/p>\n


          <\/section>\n

          \u53c2\u8003\u6587\u732e<\/span><\/p>\n


          <\/p>\n

            \n
          1. \n

            M. Ale\u010dkovi\u0107, et al. Metastasis as a systemic disease: molecular insights and clinical implications.BBA – Reviews on Cancer 1872 (2019) 89\u2013102<\/p>\n<\/li>\n

          2. \n

            Jake S O’Donnell et al, Cancer immunoediting and resistance to T cell-based immunotherapy, Nat Rev Clin Oncol . 2019 Mar;16(3):151-167.<\/span><\/p>\n<\/li>\n

          3. \n

            Phuong H. D. Nguyen et al, Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.NATURE COMMUNICATIONS ,(2022) 13:1441<\/span><\/p>\n<\/li>\n<\/ol>\n


            <\/p>\n

            \u2014 THE  END \u2014<\/span><\/p>\n


            <\/p>\n

            \u6765\u6e90 | \u95f2\u8c08 Immunology<\/span><\/section>\n
            <\/span><\/section>\n
            \u4f5c\u8005 | \u6311\u98df\u7684\u55b5<\/span><\/span><\/section>\n

            <\/section>\n


            <\/p>\n

            \u2589  \u5f3a\u70c8\u63a8\u8350<\/strong><\/strong><\/p>\n

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            \u672c\u516c\u4f17\u53f7\u4e0a\u7684\u5f80\u671f\u6587\u7ae0\u540c\u6b65\u53d1\u5e03\u81f3\u5bf9\u5e94\u7f51\u7ad9OncoLab\u5b9e\u9a8c\u5ba4\u3002<\/p>\n

            \u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

            \u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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            \u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u4e3b\u8981\u662f\u4e3a\u4e86\u65b9\u4fbf\u56e2\u961f\u6210\u5458\u4f7f\u7528\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

            \u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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            \u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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            \u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n


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            \u514d\u8d39\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n

            \u7528\u4e8eOncoLab\u8bfb\u8005\u4ea4\u6d41\u4e92\u52a9
            <\/span><\/p>\n


            <\/p>\n


            <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

            \u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
            \u90fd\u9700\u8981<\/span><\/section>\n
            \n

            \u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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