{"id":4477,"date":"2022-05-14T21:55:50","date_gmt":"2022-05-14T13:55:50","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2022\/05\/14\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e4%b8%89%e5%88%86%e5%9e%8b%e4%b8%8e%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e6%8a%91%e5%88%b6%e5%89%82%e6%b2%bb%e7%96%97\/"},"modified":"2022-05-14T21:55:50","modified_gmt":"2022-05-14T13:55:50","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e4%b8%89%e5%88%86%e5%9e%8b%e4%b8%8e%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e6%8a%91%e5%88%b6%e5%89%82%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2022\/05\/14\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e4%b8%89%e5%88%86%e5%9e%8b%e4%b8%8e%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e6%8a%91%e5%88%b6%e5%89%82%e6%b2%bb%e7%96%97\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u4e09\u5206\u578b\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597"},"content":{"rendered":"
\n
\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\uff0c\u9664\u4e86\u5173\u6ce8\u80bf\u7624\u7ec6\u80de\u672c\u8eab\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u7c7b\u522b\uff0c\u6570\u91cf\uff0c\u529f\u80fd\u4e0e\u4e5f\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u606f\u606f\u76f8\u5173\u3002<\/span><\/section>\n
\u6839\u636e\u514d\u75ab\u6d78\u6da6\uff0c\u53ef\u5c06\u80bf\u7624\u5206\u4e3a\u4e09\u79cd\u514d\u75ab\u5206\u578b<\/span><\/section>\n
    \n
  1. \n

    \u514d\u75ab\u708e\u75c7\u578b\uff08inflamed\uff09\uff1a\u80bf\u7624\u5468\u56f4\u6709\u514d\u75ab\u7ec6\u80de\u6d78\u6da6<\/span><\/p>\n<\/li>\n

  2. \n

    \u514d\u75ab\u6392\u9664\u578b<\/span>\uff08Immune exclued\uff09\uff1a\u80bf\u7624\u5fae\u73af\u5883\u6392\u9664\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80deTILs<\/span><\/p>\n<\/li>\n

  3. \n

    \u514d\u75ab\u6c99\u6f20\u578b\uff08Immune desert\uff09\uff1a\u514d\u75ab\u7ec6\u80de\u8fdc\u79bb\u80bf\u7624\u7ec6\u80de\uff0c\u5fae\u73af\u5883\u57fa\u672c\u65e0\u514d\u75ab\u7ec6\u80de\u3002<\/span><\/p>\n<\/li>\n<\/ol>\n


    <\/p>\n


    <\/p>\n

    #1<\/strong><\/span><\/section>\n
    \u708e\u75c7\u578b\u80bf\u7624<\/strong><\/span><\/section>\n

    <\/strong><\/span><\/section>\n
    \u708e\u75c7\u578b\u80bf\u7624\uff0c\u80bf\u7624\u7ec6\u80de\u8868\u8fbePD-L1\uff0c\u80bf\u7624\u5fae\u73af\u5883\u6709\u8f83\u591a\u7684\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\uff0c\u8f83\u9ad8\u9891\u7387\u7684\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs)\u3002<\/span><\/section>\n
    \u708e\u75c7\u578b\u80bf\u7624\u5bf9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u654f\u611f<\/span><\/strong>\u3002\u5982\u679c\u80bf\u7624\u542b\u6709\u5927\u91cf\u6d46\u7ec6\u80de\u6837B\u7ec6\u80de\u7684\u75c5\u4eba\uff0c\u5bf9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u4e5f\u662f\u654f\u611f\u7684\uff0c\u53ef\u80fd\u673a\u5236\u662fB\u7ec6\u80de\u4fc3\u8fdbT\u7ec6\u80de\u6fc0\u6d3b\uff0c\u5b58\u6d3b\uff0c\u8d77\u5230\u6297\u80bf\u7624\u514d\u75ab\u3002<\/span><\/section>\n

    <\/section>\n
    \u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff08MSI),\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u5219\u589e\u52a0\u4e86\u80bf\u7624\u6297\u539f\u6027\uff0c\u63d0\u4f9b\u7ed9\u514d\u75ab\u7cfb\u7edf\u7279\u5f02\u6027\u7684\u5916\u6765\u6297\u539f\u3002\u80bf\u7624\u65e9\u671f\u53d1\u751f\u7684\u5171\u6709\u7a81\u53d8(\u4e5f\u79f0\u514b\u9686\u7a81\u53d8\uff09\u53ef\u4ee5\u8bf1\u5bfc\u4ea7\u751f\u66f4\u6709\u6548\u7684\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\uff1b\u800c\u4e4b\u540e\u53d1\u751f\u7684\u7a81\u53d8\uff0c\u53ef\u80fd\u53ea\u662f\u5b58\u5728\u4e8e\u90e8\u5206\u80bf\u7624\u7ec6\u80de\u4e9a\u7fa4\uff08\u4e5f\u6210\u4e3a\u4e9a\u514b\u9686\u7a81\u53d8\uff09\u3002\u8fd9\u79cd\u80bf\u7624\u6297\u539f\u7684\u8bc6\u522b\uff0c\u7279\u522b\u662f\u65b0\u6297\u539f\u5bf9\u4e8e\u6297\u80bf\u7624\u514d\u75ab\u5468\u671f\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002<\/span><\/section>\n
    TMB\u5c24\u5176\u662fMSI\u9ad8\u7684\u80bf\u7624\uff0c\u5bf9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u654f\u611f\u3002\u4f46\u662f\u4e5f\u6709\u62a5\u9053\u663e\u793a\u5355\u7eafTMB\u5e76\u4e0d\u80fd\u5f88\u597d\u9884\u6d4b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u54cd\u5e94\u3002<\/span><\/section>\n

    <\/section>\n
    \u708e\u75c7\u578b\u80bf\u7624\u901a\u8fc7\u4fc3\u8fdb\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\uff08HLA\uff09\u4f4d\u70b9\u6742\u5408\u6027\u4e27\u5931\uff08HLA-LOH<\/strong>\uff09\uff0c\u800c\u8fdb\u884c\u514d\u75ab\u7f16\u8f91<\/strong>\uff0c\u4f7f\u5f97\u514d\u75ab\u7ec6\u80de\u4e27\u5931\u6297\u539f\u9012\u5448\u80fd\u529b\uff0c\u4ece\u800c\u5f71\u54cdT\u7ec6\u80de\u6d3b\u5316\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\uff0c\u4e0d\u540c\u6297\u539f\u53ca\u8868\u4f4d\u5bf9\u4e8e\u6297\u539f\u9012\u5448\u7684\u5f71\u54cd\u3002\u636e\u63a8\u6d4bT\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\u662f\u9488\u5bf9\u5404\u79cd\u8868\u4f4d\u7684\uff0c\u800c\u5bf9\u7279\u5b9a\u8868\u4f4d\u7684\u53cd\u5e94\u7684\u76f8\u5bf9\u91cd\u8981\u6027\u662f\u968f\u673a\u7684\uff0c\u8fd9\u662f\u7531\u4e8e\u54cd\u5e94\u7684T\u7ec6\u80de\u542f\u52a8\u3001\u6fc0\u6d3b\u3001\u523a\u6fc0\u548c\u5b58\u6d3b\u4e4b\u95f4\u7684\u65f6\u95f4\u7ade\u4e89\u9020\u6210\u7684\u3002<\/span><\/section>\n

    <\/section>\n
    \u5728\u5927\u591a\u6570\u764c\u75c7\u60a3\u8005\u4e2d\uff0c\u5b58\u5728\u591a\u79cd\u514d\u75ab\u539f\u65b0\u6297\u539f\uff0c\u5e76\u53ef\u80fd\u5f15\u8d77\u591a\u79cdT\u7ec6\u80de\u53cd\u5e94\u3002\u8fd9\u4e9bT\u7ec6\u80de\u53cd\u5e94\u7684\u5e7f\u5ea6\u53ef\u80fd\u6709\u52a9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6cbb\u7597\u6301\u4e45\u6027\u3002\u7136\u800c\uff0c\u8003\u8651\u5230\u80bf\u7624\u5185\u5f02\u8d28\u6027\uff0c\u7ed9\u5b9a\u7684T\u7ec6\u80de\u5bf9\u5355\u4e2a\u65b0\u6297\u539f\u7684\u53cd\u5e94\u7684\u91cd\u8981\u6027\u66f4\u96be\u8bc4\u4f30\uff0c\u8fd9\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u5185T\u7ec6\u80de\u523a\u6fc0\u548c\u6291\u5236\u7684\u968f\u673a\u6027\u6709\u5173\u3002\u8fd9\u4e0e\u6297\u75c5\u6bd2T\u7ec6\u80de\u514d\u75ab\u5f62\u6210\u4e86\u9c9c\u660e\u7684\u5bf9\u6bd4\uff0c\u5bf9\u7279\u5b9a\u75c5\u6bd2\u8868\u4f4d\u7684\u663e\u6027\u514b\u9686T\u7ec6\u80de\u53cd\u5e94\uff0c\u76f4\u5230\u6b64\u75c5\u6bd2\u8868\u4f4d\u4e22\u5931\u624d\u4f1a\u505c\u6b62\uff0c\u5728\u6b64\u4e4b\u540e\uff0c\u53ef\u80fd\u4f1a\u51fa\u73b0\u4e00\u79cd\u65b0\u7684\u9488\u5bf9\u4e0d\u540c\u75c5\u6bd2\u8868\u4f4d\u7684\u663e\u6027\u514b\u9686T\u7ec6\u80de\u53cd\u5e94\u3002<\/span><\/section>\n

    <\/section>\n
    \u591a\u4e2a\u4e34\u5e8a3\u671f\u7684\u5b9e\u9a8c\u8bc4\u4ef7\u4e86PD-L1\u8868\u8fbe\u6c34\u5e73\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6cbb\u7597\u54cd\u5e94\u76f8\u5173\u6027\uff08Keynote-024, Keynote-042, IMpower110,and Checkmate-227<\/span>)\uff0c\u4f46\u4e5f\u6709\u7814\u7a76\u8ba4\u4e3aPD-L1\u8868\u8fbe\u4f5c\u4e3a\u5355\u4e00\u8bc4\u4ef7\u6307\u6807\u610f\u4e49\u4e0d\u5927\uff08<\/span>JAMA Onco\uff1aPD-L1\u9633\u6027\u7387\u65e0\u6cd5\u9884\u6d4bPD-1\/PD-L1\u6297\u4f53\u836f\u7269\u5e94\u7b54\u7387<\/a>\uff09\u3002<\/span>
    <\/section>\n
    TMB\u548cPD-L1\u662f\u72ec\u7acb\u7684\u6807\u8bb0\u7269\uff0c\u5728\u60a3\u8005\u80bf\u7624\u4e2d\u4e0d\u4e00\u5b9a\u4e00\u81f4\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u9ad8TMB\u548c\u514d\u75ab\u6c99\u6f20\u578b\u80bf\u7624\u8f6c\u79fb\u6027\u8180\u80f1\u764c\u60a3\u8005\uff0c\u5f53\u6709\u9ad8PD-L1\u8868\u8fbe\u65f6\uff0c\u60a3\u8005\u4f1a\u4ece\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u53ef\u80fd\u662f\u56e0\u4e3a\u7f3a\u5c11\u514d\u75ab\u538b\u529b\uff0c\u6240\u4ee5\u80bf\u7624\u4e0d\u4f1a\u901a\u8fc7\u8bf1\u5bfcHLA\u4e22\u5931\u6765\u8fdb\u884c\u514d\u75ab\u7f16\u8f91\uff0c\u53cd\u800c\u56e0\u4e3a\u9ad8TMB\uff0c\u4ea7\u751f\u9ad8\u6297\u539f\u9012\u5448\u3002\u6cdb\u80bf\u7624KEYNOTE-158\u8bd5\u9a8c\u4e2d\uff0c\u89c2\u5bdf\u6d3e\u59c6\u5355\u6297(Pembrolizumab)\u5355\u836f\u6cbb\u7597\u54cd\u5e94\u7387\uff0c\u5728\u9ad8TMB\uff0828.3%\u5ba2\u89c2\u53cd\u5e94\u7387[ORR]\uff09\u548c\u4f4eTMB\uff086.5%ORR\uff09\u3002\u7814\u7a76\u4e86\u591a\u79cd\u5178\u578b\u7684\u975e\u708e\u75c7\u6027\u764c\u75c7\uff0c\u5305\u62ec\u809b\u95e8\u3001\u80c6\u9053\u3001\u5bab\u9888\u3001\u5b50\u5bab\u5185\u819c\u3001\u553e\u6db2\u3001\u7532\u72b6\u817a\u764c\u3001\u95f4\u76ae\u7624\u548cSCLC\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u5047\u8bbe\u3002\u8fd9\u4e5f\u6697\u793a\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5728\u5916\u56f4\u542f\u52a8\u65b0\u7684T\u7ec6\u80de\u53cd\u5e94\u4e2d\u7684\u989d\u5916\u4f5c\u7528\uff0c\u8fd9\u53cd\u8fc7\u6765\u53c8\u5bfc\u81f4\u4e86\u6301\u4e45\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/section>\n

    <\/section>\n
    \u8bb8\u591a\u764c\u75c7\u7684\u7279\u70b9\u662f\u708e\u75c7\u7684\u5b58\u5728\uff0c\u6ca1\u6709\u9ad8\u7684TMB\u3002\u6bd4\u5982\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u3001\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u3001\u80c3\u764c\uff0c\u4ee5\u53ca\u67d0\u4e9b\u5934\u9888\u90e8\u764c\u75c7\u3002\u76f8\u53cd\uff0c\u5c0f\u7ec6\u80de\u80ba\u764c\uff08SCLC\uff09\u7b49\u4ee5\u9ad8TMB\u4e3a\u7279\u5f81\u7684\u80bf\u7624\uff0c\u800c\u6ca1\u6709\u5176\u4ed6\u4e0e\u708e\u75c7\u80bf\u7624\u76f8\u5173\u7684\u6807\u8bb0\u7269\u3002\u73b0\u5728\u4eba\u4eec\u5df2\u7ecf\u5f88\u6e05\u695a\uff0c\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u5e76\u4e0d\u662f\u80bf\u7624\u4e2d\u764c\u75c7\u6297\u539f\u7684\u552f\u4e00\u6765\u6e90\u3002\u50cf\u900f\u660e\u7ec6\u80deRCC\uff0c\u524d\u5217\u817a\u764c\u4e9a\u7fa4\uff0c\u751a\u81f3\u5375\u5de2\u764c\uff0c\u90fd\u6709\u5f88\u9ad8\u7684\u4eba\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff08HERVS\uff09\u60a3\u75c5\u7387\u3002\u6574\u5408\u5230\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684HERVS\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u57fa\u672c\u4e0a\u662f\u6c89\u9ed8\u7684\uff0c\u4f46\u5728\u764c\u75c7\u4e2d\u4f1a\u53d8\u5f97\u5931\u8c03\u548c\u91cd\u65b0\u8868\u8fbe\uff1b\u56e0\u6b64\uff0cHERVS<\/span>\u53ef\u4ee5\u4f5c\u4e3a\u80bf\u7624\u6297\u539f\u4fe1\u53f7\u3002\u8868\u8fbe\u5927\u91cfHERV\u7684RCC\u80bf\u7624\u4e5f\u8868\u8fbe\u4e86IFN-\u03b3\u4fe1\u53f7\uff0c\u8868\u660e\u8fd9\u4e9b\u80bf\u7624\u786e\u5b9e\u53d1\u708e\u4e86<\/strong>\u3002\u5728RCC\u80bf\u7624\u548c\u5916\u5468\u8840\u4e2d\u89c2\u5bdf\u5230T\u7ec6\u80de\u5bf9HERV\u6297\u539f\u7684\u53cd\u5e94\uff0cRCC\u60a3\u8005\u5728\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u51fa\u73b0\u51cf\u9000\uff0c\u6240\u6709\u8fd9\u4e9b\u90fd\u8868\u660eHERV\u786e\u5b9e\u53ef\u4ee5\u5728\u8fd9\u4e9b\u764c\u75c7\u4e2d\u63d0\u4f9b\u6297\u539f\u4fe1\u53f7\u3002<\/span><\/section>\n

    <\/section>\n
    \u9664\u4e86HERVs\u75c5\u6bd2\u5916\uff0c\u8bf8\u5982epstein-barr\u75c5\u6bd2\u3001\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u3001\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u3001\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\u548c\u9ed8\u514b\u5c14\u7ec6\u80de\u591a\u7624\u75c5\u6bd2\u7b49\u75c5\u6bd2\u4e5f\u53ef\u80fd\u4e3a\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u809d\u764c\u3001\u5bab\u9888\u764c\u3001\u9ed8\u514b\u5c14\u7ec6\u80de\u764c\u4ee5\u53ca\u80c3\u764c\u7684\u67d0\u4e9b\u4e9a\u7fa4\u7b49\u764c\u75c7\u4e2d\u7684\u5f3a\u514d\u75ab\u539f\u6297\u539f\u63d0\u4f9b\u6765\u6e90\u3002<\/span><\/section>\n

    <\/section>\n
    \u867d\u7136\u5728\u67d0\u4e9b\u764c\u75c7\u4e2d\uff0c\u75c5\u6bd2\u72b6\u6001\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6cbb\u7597\u7ed3\u679c\u6ca1\u6709\u660e\u663e\u7684\u8054\u7cfb\uff0c\u4f46\u75c5\u6bd2\u57fa\u56e0\u7ec4\u6574\u5408\u5230\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u4e2d\uff0c\u5bfc\u81f4\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u7684\u4f5c\u7528\uff0c\u5df2\u7ecf\u5f97\u5230\u5145\u5206\u8bc1\u5b9e\u3002<\/span><\/section>\n
    \u56e0\u6b64\uff0c\u4e0e\u708e\u75c7\u578b\u80bf\u7624\u5e7f\u6cdb\u5730\u5305\u62ec\u90a3\u4e9b\u8868\u8fbePD-L1\u548c\u9ad8TMB\u7684\u80bf\u7624\uff0c\u800c\u4e14\u8fd8\u5305\u62ec\u8868\u8fbeHERV\u548c\u5176\u4ed6\u75c5\u6bd2\u57fa\u56e0\u7ec4\u7684\u764c\u75c7\u3002\u867d\u7136\u5df2\u89c2\u5bdf\u5230\u8fd9\u4e9b\u80bf\u7624\u7c7b\u578b\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5355\u4e00\u836f\u7269\u6cbb\u7597\u6548\u679c\u826f\u597d\uff0c\u4f46\u662f\u4e00\u4e9b\u8054\u5408\u7528\u836f\u53ef\u80fd\u6548\u679c\u66f4\u597d\u3002<\/span><\/section>\n

    <\/span><\/section>\n
    2#
    <\/span><\/strong><\/span>\u514d\u75ab\u6392\u9664\u578b\u80bf\u7624<\/span><\/strong><\/span><\/section>\n


    <\/p>\n

    \u514d\u75ab\u8c41\u514d\u578b\u80bf\u7624\uff1a\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u5b58\u5728\u6291\u5236\u6027T\u7ec6\u80de<\/strong>\uff0c\u4ed6\u4eec\u6709\u9ad8\u7684TGF-\u03b2\u4fe1\u53f7<\/strong>\uff0c\u9ad3\u7cfb\u708e\u75c7\u548c\u80bf\u7624\u8840\u7ba1\u751f\u6210\u3002<\/span><\/section>\n
    \u514d\u75ab\u6392\u9664\u578b\u80bf\u7624\u548c\u95f4\u8d28\u4fc3\u7ea4\u7ef4\u751f\u957f\u80bf\u7624\u4e0d\u540c\u3002\u95f4\u8d28\u4fc3\u7ea4\u7ef4\u751f\u957f\u7684\u80bf\u7624\u9ad8\u8868\u8fbePD-L1\uff0c\u5bf9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u654f\u611f\u3002\u867d\u7136\u95f4\u8d28\u4fc3\u7ea4\u7ef4\u751f\u957f\u80bf\u7624\u4fb5<\/span><\/span>\u88ad\u8fb9\u7f18\u88abCD8T\u7ec6\u80de\u5bc6\u96c6\u5730\u586b\u5145\uff0c\u7ec4\u7ec7\u5b66\u4e0a\u4e0e\u514d\u75ab\u6392\u9664\u578b\u80bf\u7624\u76f8\u4f3c\u3002\u4f46\u662f<\/span>\u514d\u75ab\u6392\u9664\u578b\u7684\u80bf\u7624\u5f80\u5f80\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53cd\u5e94\u5f88\u5dee<\/strong><\/span>\u3002<\/span><\/section>\n
    TGF-\u03b2\u4fc3\u8fdb\u514d\u75ab\u6392\u9664\u8868\u578b\uff0c\u964d\u4f4ePD-L1\u6291\u5236\u5242\u7684\u4f5c\u7528<\/span><\/strong>\u3002\u6291\u5236TGF-\u03b2\u6709\u52a9\u4e8e\u5c06\u80bf\u7624\u5411\u708e\u75c7\u578b\u8868\u578b\u8f6c\u5316\uff0caPDL1+aTGFb\u56e0\u4e3a\u53ef\u4ee5\u4ea7\u751f\u4e00\u4e9b\u4e34\u5e8a\u53d7\u76ca(NCT02734160,NCT04064190, NCT02947165)\u3002<\/span><\/section>\n
    \u9ad3\u6837\u708e\u75c7\u5728\u708e\u75c7\u578b\u80bf\u7624\u548c\u514d\u75ab\u8c41\u514d\u578b\u80bf\u7624\u7684\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8868\u8fbeIL-6\u548cIL-8\u7b49\u7ec6\u80de\u56e0\u5b50\u76f8\u5173\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u548c\u6297\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u6297\u4f53\u7684\u8054\u5408\u4f7f\u7528\u662f\u5426\u80fd\u591f\u83b7\u76ca\uff0c\u8fd8\u6709\u5f85\u8fdb\u4e00\u6b65\u7684\u6d4b\u8bd5\uff08NCT03400332\uff0cNCT03866239)\u3002<\/span><\/section>\n
    \u6297\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\u53d7\u4f53\uff08CSF1R\uff09\u7684\u8bd5\u9a8c\uff0c\u4e00\u79cd\u6d88\u8017\u80bf\u7624\u9a7b\u7559\u5de8\u566c\u7ec6\u80de\u7684\u836f\u7269\u5e76\u4e0d\u6210\u529f\u3002\u4e0d\u6e05\u695a\u662f\u5426anti-CSF1R\u5c06\u597d\u7684\u6297\u539f\u9012\u5448\u5de8\u566c\u7ec6\u80de\u548c\u6291\u5236\u6027\u7684\u5de8\u566c\u7ec6\u80de\u5747\u6e05\u9664\u4e86\u3002<\/span><\/section>\n

    <\/section>\n

    3#<\/strong><\/span><\/p>\n

    \u514d\u75ab\u6c99\u6f20\u578b\u80bf\u7624<\/strong><\/span>
    <\/p>\n


    <\/strong><\/span><\/p>\n

    <\/span><\/strong><\/span><\/section>\n
    \u514d\u75ab\u6c99\u6f20\u578b\u80bf\u7624\u7ec4\u7ec7\u7279\u5f81\u4e3a\uff1a\u7f3a\u4e4f\u514d\u75ab\u6d78\u6da6\uff0c\u7f3a\u5c11\u6297\u539f\u5448\u9012\uff08\u4f4eMHCI\uff09\uff0c\u9ad8\u80bf\u7624\u751f\u957f\u3002\u5982\u513f\u7ae5\u6076\u6027\u80bf\u7624\u3001\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548cSCLC\u3002\u9664\u4e86SCLC\u5916\uff0c\u8fd9\u4e9b\u80bf\u7624\u5728\u57fa\u56e0\u7ec4\u4e0a\u5f80\u5f80\u662f\u7a33\u5b9a\u7684\uff0c\u4f4eTMB\uff0c<\/span>\u5bf9\u5355\u836f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53cd\u5e94\u5f88\u5dee<\/strong><\/span>\u3002<\/span><\/section>\n
    \u591a\u79cd\u4e0d\u540c\u7684\u673a\u5236\u53c2\u4e0e\u514d\u75ab\u6c99\u6f20\u8868\u578b\u3002\u6bd4\u5982\u80bf\u7624\u5185\u5728WNT\/\u03b2-catenin\u4fe1\u53f7\u901a\u8def<\/strong>\uff0c\u53ef\u4ee5\u4f7fCD103\u6811\u7a81\u72b6\u7ec6\u80de\u6240\u9700\u7684\u8d8b\u5316\u56e0\u5b50CXCL1\u3001CXCL2\u548cCCL4\u68af\u5ea6\u51cf\u5c11\uff0c\u4ece\u800c\u5f71\u54cd\u65e9\u671fT\u7ec6\u80de\u7684\u542f\u52a8\u548c\u6d78\u6da6\u3002SCLC\u5728\u5185\u7684\u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624\u4ee5\u4f4e\u9891\u7387\u7684TILs\u4e3a\u4e3b\u3002<\/span><\/section>\n
    \u9664\u4e86\u9003\u907f\u514d\u75ab\u76d1\u89c6\u5916\uff0c\u5feb\u901f\u589e\u6b96\u7684\u6c99\u6f20\u80bf\u7624\u6539\u53d8\u4e86\u80bf\u7624\u5fae\u73af\u5883\u7684\u4ee3\u8c22<\/strong>\uff0c\u4e3aT\u7ec6\u80de\u7684\u529f\u80fd\u548c\u589e\u6b96\u521b\u9020\u4e86\u4e00\u4e2a\u654c\u5bf9\u7684\u73af\u5883\u3002<\/span><\/section>\n
    \u7f3a\u6c27\u3001\u4e73\u9178\u751f\u6210\u3001\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u7684\u5b58\u5728\u548c\u8102\u80aa\u751f\u6210\u7684\u589e\u52a0\uff0c\u5171\u540c\u6539\u53d8\u4e86T\u7ec6\u80de\u7684\u514d\u75ab\u4ee3\u8c22\uff0c\u5f71\u54cdTCR\u7684\u53c2\u4e0e\u3001T\u6548\u5e94\u6fc0\u6d3b\u3001\u5206\u5316\u548c\u589e\u6b96\uff0c\u6700\u7ec8\u5bfc\u81f4TILs\u7684\u51cf\u5c11\u3002<\/span><\/section>\n
    \u901a\u8fc7\u4ee3\u8c22\u9014\u5f84\u8c03\u8282\u5242\u6765\u89e3\u51b3\u80bf\u7624\u7ec6\u80de\u7684\u4ee3\u8c22\u91cd\u65b0\u7f16\u7a0b\u662f\u975e\u5e38\u91cd\u8981\u7684\uff0c\u53ef\u5f71\u54cdT\u7ec6\u80de\u7684\u529f\u80fd\u3002\u8bc6\u522b\u4ee3\u8c22\u5e94\u6fc0\u7684\u80bf\u7624\uff0c\u5982HIF1A\u4f9d\u8d56\u6027\u80bf\u7624\uff0c\u4f34\u6709PI3K\/AKT\/FGFR3\u4fe1\u53f7\u7a81\u53d8\u7684\u80bf\u7624\uff0c\u6291\u5236\u8fd9\u4e9b\u764c\u7ec6\u80de\u4f9d\u8d56\u4fe1\u901a\u8def\u7684\u836f\u7269\u53ef\u80fd\u4f1a\u6709\u7406\u60f3\u7684\u6548\u679c\uff0c\u540c\u65f6\u4f7f\u514d\u75ab\u7ec6\u80de\u4e0d\u53d7\u5e72\u6270\uff0c\u7ed3\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u4f1a\u5728\u8fd9\u4e9b\u80bf\u7624\u4e2d\u521b\u9020\u4e00\u4e2a\u514d\u75ab\u8bb8\u53ef\u7684\u5fae\u73af\u5883\u3002
    <\/span><\/section>\n

    <\/p>\n

    \u4e0a\u8ff0\u708e\u75c7\u578b\u3001\u514d\u75ab\u8c41\u514d\u578b\u548c\u514d\u75ab\u6c99\u6f20\u578b\uff0c\u5728\u7279\u5b9a\u7684\u80bf\u7624\u7c7b\u578b\u548c\u4e0d\u540c\u7684\u764c\u75c7\u4e2d\uff0c\u4e0d\u540c\u7a0b\u5ea6\u4e0a\u666e\u904d\u5b58\u5728\u3002<\/span><\/section>\n
    \u4e0a\u56fe\u5bf9\u6bcf\u79cd\u764c\u75c7\u7684\u5927\u81f4\u514d\u75ab\u8868\u578b\u8fdb\u884c\u4e86\u5206\u7c7b\uff0c\u4ee5\u53ca\u4ed6\u4eec\u548cTMB\u7684\u5173\u7cfb\u3002\u603b\u4f53\u4e34\u5e8a\u6311\u6218\u4ecd\u7136\u662f\u5b9a\u4e49\u708e\u75c7\u578b\u80bf\u7624\u6216\u6297\u539f\u8d1f\u8377\u9ad8\u7684\u80bf\u7624\u9608\u503c\uff0c\u4ee5\u53ca\u786e\u5b9a\u4e0e\u7279\u5b9a\u8868\u578b\u76f8\u5173\u7684\u7279\u5b9a\u9a71\u52a8\u56e0\u7d20\u3002<\/span><\/section>\n

    <\/span><\/section>\n
    \u5982\u4e0a\u6240\u8ff0\uff0c\u8054\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u8f6c\u5316\u5c06\u9700\u8981\u786e\u5b9a\u6b63\u786e\u7684\u60a3\u8005\u7fa4\u4f53\uff0c\u4ee5\u5c06\u514d\u75ab\u6c99\u6f20\u6216\u514d\u75ab\u6392\u9664\u7684\u80bf\u7624\u8f6c\u5316\u4e3a\u708e\u75c7\u80bf\u7624<\/strong>\u3002\u867d\u7136CD8\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\uff08IHC\uff09\u53ef\u80fd\u8db3\u4ee5\u5bf9\u80bf\u7624\u8fdb\u884c\u5e7f\u6cdb\u7684\u5206\u7c7b\uff0c\u4f46\u8bc6\u522b\u7279\u5b9a\u7684\u9014\u5f84\u9a71\u52a8\u56e0\u7d20\uff0c\u5982TGF-\u03b2\u3001\u9ad3\u7cfb\u7ec6\u80de\u3001WNT\/b-catenin\u6216\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff0c\u5c06\u9700\u8981\u540c\u6837\u590d\u6742\u7684\u751f\u7269\u6807\u5fd7\u7269\u65b9\u6cd5\u6765\u8fdb\u884c\u5206\u7c7b\u3002<\/span><\/section>\n
    \u53c2\u8003\u6587\u732e<\/span><\/section>\n
      \n
    1. \n

      Hegde, P.S., Karanikas, V., and Evers, S. (2016). The Where, theWhen, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition. Clin. Cancer Res. 22, 1865\u20131874.<\/span><\/p>\n<\/li>\n

    2. \n

      Marabelle, A.,  J.A., Miller, A., et al.(2019). Association of tumor mutational burden with outcomes in patients with select advanced solid tumors treated with pembrolizumab in KEYNOTE-158. ESMO 2019 Congress. Ann. Oncol. 30, v475\u2013v532.<\/span><\/p>\n<\/li>\n

    3. \n

      Mariathasan, S, et al. (2018). TGFb attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature 554, 544\u2013548.<\/span><\/p>\n<\/li>\n

    4. \n

      McDermott, D.F, et al. (2018). Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma. Nat. Med. 24,749\u2013757.<\/span><\/p>\n<\/li>\n

    5. \n

      Top 10 Challenges in Cancer Immunotherapy\uff0cPriti S. Hegde and Daniel S. Chen\uff0cImmunity 52, January 14, 2020<\/span><\/p>\n<\/li>\n

    6. \n

      McDermott, D.Fet al. (2018). Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma. Nat. Med. 24,749\u2013757.<\/span><\/p>\n<\/li>\n<\/ol>\n

      \u2014 THE  END \u2014<\/span><\/p>\n


      <\/p>\n

      \u6765\u6e90 | \u95f2\u8c08Immunology<\/span><\/section>\n

      <\/section>\n


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      \u672c\u516c\u4f17\u53f7\u4e0a\u7684\u5f80\u671f\u6587\u7ae0\u540c\u6b65\u53d1\u5e03\u81f3\u5bf9\u5e94\u7f51\u7ad9OncoLab\u5b9e\u9a8c\u5ba4\u3002<\/p>\n

      \u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

      \u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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      \u2589  OncoLab\u5b66\u672f\u5bfc\u822a<\/strong><\/strong><\/p>\n

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      \u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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      \u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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      OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

      \u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

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      \u5173\u6ce8\u672c\u53f7~<\/span>
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      \u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n


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      \u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n

      \u7528\u4e8eOncoLab\u8bfb\u8005\u4ea4\u6d41\u4e92\u52a9\u6c38\u4e45\u514d\u8d39
      <\/span><\/p>\n


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      \u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
      \u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/section>\n
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      \u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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