{"id":4541,"date":"2022-07-20T23:28:35","date_gmt":"2022-07-20T15:28:35","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2022\/07\/20\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac11%e7%ab%a0%ef%bc%9a%e8%8d%af%e7%89%a9%e5%af%b9%e9%aa%a8%e9%ab%93%e6%ba%90%e6%80%a7%e6%8a%91%e5%88%b6%e7%bb%86%e8%83%9emdsc%e7%9a%84%e5%bd%b1\/"},"modified":"2022-07-20T23:28:35","modified_gmt":"2022-07-20T15:28:35","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac11%e7%ab%a0%ef%bc%9a%e8%8d%af%e7%89%a9%e5%af%b9%e9%aa%a8%e9%ab%93%e6%ba%90%e6%80%a7%e6%8a%91%e5%88%b6%e7%bb%86%e8%83%9emdsc%e7%9a%84%e5%bd%b1","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2022\/07\/20\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac11%e7%ab%a0%ef%bc%9a%e8%8d%af%e7%89%a9%e5%af%b9%e9%aa%a8%e9%ab%93%e6%ba%90%e6%80%a7%e6%8a%91%e5%88%b6%e7%bb%86%e8%83%9emdsc%e7%9a%84%e5%bd%b1\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c11\u7ae0\uff1a\u836f\u7269\u5bf9\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de(MDSC)\u7684\u5f71\u54cd\uff08\u4e0a\uff09"},"content":{"rendered":"
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11.1 \u4ecb\u7ecd<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de<\/strong>(MDSCs<\/strong>)\u662f\u4e00\u7c7b\u53d1\u6325\u514d\u75ab\u6291\u5236<\/strong>\u529f\u80fd\u7684\u9ad3\u7cfb\u7ec6\u80de\u3002<\/p>\n

MDSCs\u4e0d\u540c\u4e8e\u5de8\u566c\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de(DC)\u6216\u4e2d\u6027\u7c92\u7ec6\u80de\u7b49\u7ec8\u672b\u5206\u5316\u7684\u9ad3\u6837\u7ec6\u80de\uff0c\u5b83\u662f\u5728\u9aa8\u9ad3\u4e2d\u4ea7\u751f\u7684\u9020\u8840\u7ec6\u80de\uff0c\u5e76\u53ef\u5206\u4e3a\u4e24\u79cd\u4e9a\u578b<\/strong>\u2014\u5355\u6838MDSCs\u4e0e\u591a\u6838MDSCs\u3002\u5355\u6838MDSCs<\/strong>\u6765\u6e90\u4e8e\u5de8\u566c\u7ec6\u80de\/DC\u524d\u4f53<\/strong>\u7ec6\u80de\uff0c\u800c\u591a\u6838(PMN)MDSCs<\/strong>\u6765\u6e90\u4e8e\u9ad3\u7cfb\u5206\u5316\u7684\u7c92\u7ec6\u80de<\/strong>\u3002<\/p>\n

\u5728\u4eba\u7c7b\u548c\u8001\u9f20\u8eab\u4e0a\u90fd\u53ef\u4ee5\u53d1\u73b0\u8fd9\u4e24\u79cd\u4e9a\u578b\u3002\u5728\u4eba\u7c7b\u4e2d\uff0cM-MDSCs<\/strong>\u7684\u7279\u70b9\u662f\u8868\u8fbeCD14\u3001CD11b\u548cCD33<\/strong>\u57fa\u56e0\uff0c\u800c\u8c31\u7cfb\u6807\u5fd7\u7269\u548cHLA-DR<\/strong>\u5448\u4f4e\u8868\u8fbe\u3002PMN-MDSCs<\/strong>\u8868\u8fbeCD15\u3001CD11b\u548cCD33<\/strong>\uff0c\u800c\u8c31\u7cfb\u6807\u5fd7\u7269<\/strong>\u548cHLA-DR<\/strong>\u8868\u8fbe\u5448\u9634\u6027\u3002<\/p>\n

\u901a\u8fc7\u4e0d\u540c\u7684\u5bc6\u5ea6<\/strong>\u53ef\u4ee5\u533a\u5206PMN-MDSC\u548cPMN(\u7c92\u7ec6\u80de)\u3002<\/p>\n

\u867d\u7136\u7814\u7a76\u53d1\u73b0\u8bb8\u591a\u6807\u8bb0\u7269\u80fd\u8fdb\u4e00\u6b65\u9274\u5b9aMDSC\uff0c\u4f46\u8fd8\u6ca1\u6709\u4e00\u4e2a\u6807\u8bb0\u88ab\u8ba4\u4e3a\u662f\u7279\u5f02\u6027\u7684MDSC\u6807\u8bb0<\/strong>\u3002\u6700\u8fd1Dmitry Gabrilovich\u7814\u7a76\u5c0f\u7ec4\u8bc1\u660e\uff0cLOX1<\/strong>\u6807\u8bb0\u53ef\u4ee5\u533a\u5206\u4eba\u7c7b\u7684PMN-MDSC\u548cPMN\u3002<\/p>\n

\u5728\u5c0f\u9f20\u8eab\u4e0a\uff0c\u5219\u7528\u4e0d\u540c\u7684\u5206\u5b50\u63cf\u8ff0MDSCs\u7fa4\u3002\u901a\u8fc7\u8bc6\u522bCD11b\u548cGr-1<\/strong>\u53ef\u4ee5\u533a\u5206MDSC\u7684\u4e24\u4e2a\u4e9a\u7fa4\u3002<\/p>\n

Gr-1<\/strong>\u662fLy6C\u548cLy6G\u4e24\u4e2a\u6807\u8bb0\u7684\u7ec4\u5408\u3002\u5229\u7528\u8fd9\u4e9b\u6807\u8bb0\u53ef\u4ee5\u66f4\u51c6\u786e\u5730\u5206\u79bbMDSC\u7fa4\uff0cM-MDSCs<\/strong>\u4e3aLy6C+<\/sup>\u548cLy6G\uff0c\u800cPMN-MDSCs<\/strong>\u4e3aLy6G+<\/sup>\u548cLy6C\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6211\u4eec\u51e0\u4e4e\u65e0\u6cd5\u5728\u5065\u5eb7\u4e2a\u4f53\u4e2d\u68c0\u6d4b\u5230MDSCs<\/strong>\u3002\u4f46\u662f\u5728\u67d0\u4e9b\u60c5\u51b5\u5982\u6025\u6027\u611f\u67d3<\/strong>(\u8113\u6bd2\u75c7)\u3001\u6162\u6027\u611f\u67d3<\/strong>(\u7ed3\u6838\u75c5)\u6216\u764c\u75c7<\/strong>\u4e2d\u5374\u53ef\u4ee5\u68c0\u6d4b\u5230MDSCs\u7684\u79ef\u805a<\/strong>\u3002<\/p>\n

\u5982\u80bf\u7624\u7ec6\u80de\u5206\u6ccc\u7684GM-CSF\u3001G-CSF\u3001SCF\u6216S100A8\u3001S100A9<\/strong>\u7b49\u56e0\u5b50\u4fbf\u53ef\u4f7f\u5f97MDSCs\u589e\u6b96\u3002<\/p>\n

MDSCs\u4e3b\u8981\u5728\u80bf\u7624\u60a3\u8005\u7684\u80bf\u7624<\/strong>\u548c\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98<\/strong>\u4e2d\u5b58\u5728\uff0c\u4e00\u4e9b\u7814\u7a76\u4e5f\u5df2\u7ecf\u89c2\u5bdf\u5230\u5728\u9aa8\u9ad3<\/strong>\u4e2d\u4e5f\u5b58\u5728MDSCs\u7684\u805a\u96c6\u3002<\/p>\n

\u5728\u4eba\u7c7b\u548c\u5c0f\u9f20\u4e2d\u7684\u591a\u6570\u764c\u75c7<\/strong>\u4e2d\u7684\u5927\u90e8\u5206MDSCs\u662fPMN-MDSCs<\/strong>\u3002MDSCs\u53ef\u901a\u8fc7\u591a\u79cd\u65b9\u5f0f\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb<\/strong>\u3002<\/p>\n

MDSCs\u53ef\u5e2e\u52a9\u5efa\u7acb\u6709\u5229\u4e8e\u80bf\u7624\u751f\u957f\u7684\u5fae\u73af\u5883<\/strong>\uff0c\u8fd9\u8981\u5f52\u529f\u4e8e\u5b83\u4eec\u80fd\u591f\u4ea7\u751f\u4fc3\u8840\u7ba1\u751f\u6210<\/strong>\u7684\u4ecb\u8d28\uff0c\u5982VEGF\u3001bFGF\u3001MMP9\u6216PDGF<\/strong>\u7b49\u5206\u5b50\uff0c\u8fd9\u4e9b\u5206\u5b50\u5bf9\u65b0\u8840\u7ba1\u7684\u5f62\u6210\u5f88\u5173\u952e\uff0c\u800c\u65b0\u8840\u7ba1\u5bf9\u7ef4\u6301\u80bf\u7624\u751f\u957f\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

MDSCs\u5728\u80bf\u7624\u8f6c\u79fb\u7684\u542f\u52a8<\/strong>\u8fc7\u7a0b\u4e2d\u4e5f\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5728\u80bf\u7624\u7ec6\u80de\u8f6c\u79fb\u81f3\u80ba\u4e4b\u524d\u76842\u5468\u5185\uff0c\u643a\u5e26\u4e73\u817a\u764c\u7684\u5c0f\u9f20\u7684\u80ba\u4e2dMDSCs\u6570\u91cf\u5c31\u5df2\u7ecf\u589e\u52a0<\/strong>\uff0c\u5176\u589e\u52a0\u4f9d\u8d56\u4e8eMmp9<\/strong>\u7684\u4ea7\u751f\u3002\u539f\u53d1\u80bf\u7624\u8bf1\u5bfc\u5668\u5b98\u8868\u8fbe\u7684\u4fc3\u708e\u75c7\u86cb\u767dS100A8\u548cS100A9<\/strong>\uff0c\u53ef\u5438\u5f15MDSCs\u8fdb\u5165\u8f6c\u79fb\u524d\u7684\u751f\u6001\u4f4d<\/strong>\uff08ps\uff1a\u5e7f\u6cdb\u8f6c\u79fb\u4e4b\u524d\u53ef\u7531\u539f\u53d1\u80bf\u7624\u90e8\u4f4d\u5206\u6ccc\u7684\u5916\u6ccc\u4f53\u5728\u5176\u4ed6\u90e8\u4f4d\u9884\u5148\u5f62\u6210\u7684\u5fae\u73af\u5883\uff09\u3002\u5f53MDSCs\u5728\u4e00\u4e2a\u65b0\u7684\u5668\u5b98\u4e2d\u79ef\u805a\u65f6\uff0c\u5b83\u4eec\u4ea7\u751f\u7684S100A8\u548cS100A9\u53ef\u4ee5\u653e\u5927\u8fd9\u4e00\u673a\u5236\uff0c\u6709\u5229\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u8fc1\u79fb\u548c\u8f6c\u79fb\u3002<\/p>\n

\u6700\u8fd1\u7684\u7814\u7a76\u8fd8\u663e\u793a\uff0cMDSCs\u8fd8\u5177\u6709\u589e\u5f3a\u764c\u7ec6\u80de\u5e72\u6027<\/strong>\u7684\u6f5c\u529b\uff0c\u4ece\u800c\u4fc3\u8fdb\u5176\u4e0a\u76ae\u95f4\u5145\u8d28\u8f6c\u5316(EMT)\uff0c\u4ee5\u4fc3\u8fdb\u8f6c\u79fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u4e86\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u548c\u8f6c\u79fb\u5916\uff0cMDSCs\u8fd8\u80fd\u652f\u6301\u80bf\u7624\u5b58\u6d3b<\/strong>\uff0c\u8fd9\u8981\u5f52\u529f\u4e8e\u5b83\u4eec\u7684\u514d\u75ab\u6291\u5236\u7279\u6027<\/strong>\u3002<\/p>\n

MDSCs\u901a\u8fc7\u591a\u79cd\u673a\u5236\u53d1\u6325\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002<\/p>\n

MDSCs\u53ef\u4ea7\u751fIL-10\u548cTGF-\u03b2<\/strong>\u5e76\u8bf1\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de(Treg)<\/strong>\uff1b\u5b83\u4eec\u8fd8\u4f1a\u4ea7\u751f\u6d3b\u6027\u6c27<\/strong>\uff0c\u5982O2<\/sub>\u2212<\/sup>\u548cH2<\/sub>O2<\/sub>\u548cNO\u3002<\/p>\n

MDSCs\u7531\u4e8e\u8868\u8fbeArg1<\/strong>\uff0c\u6216\u7531\u4e8e\u5176\u5432\u54da\u80fa2\uff0c3-\u53cc\u52a0\u6c27\u9176(IDO<\/strong>)\u6d3b\u6027\u800c\u964d\u4f4e\u53ef\u7528\u8272\u6c28\u9178\u6c34\u5e73\uff0c\u4ece\u800c\u51cf\u5c11TCR\u7684\u5f62\u6210<\/strong>\uff0c\u5e76\u901a\u8fc7\u8017\u5c3dL-\u7cbe\u6c28\u9178\u73af\u5883\u800c\u8bf1\u5bfcT\u7ec6\u80de\u5468\u671f\u505c\u6ede<\/strong>\u3002<\/p>\n

M-MDSCs\u548cPMN-MDSCs\u5e76\u4e0d\u5177\u6709\u5b8c\u5168\u76f8\u540c\u7684\u514d\u75ab\u6291\u5236\u673a\u5236\u3002M-MDSCs<\/strong>\u6bd4PMN-MDSCs\u5177\u6709\u66f4\u9ad8\u7684\u514d\u75ab\u6291\u5236\u6d3b\u6027<\/strong>\uff0cM-MDSCs\u8868\u8fbeArg1<\/strong>\u5e76\u4ea7\u751fIL-10\u3001TGF-\u03b2\u548cNO<\/strong>\uff0cPMN-MDSCs<\/strong>\u5219\u503e\u5411\u4e8e\u4ea7\u751f\u8f83\u591aROS<\/strong>\uff08\u5b58\u5728\u65f6\u95f4\u8f83\u77ed\uff09\uff0c\u8fd9\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48PMN-MDSCs\u6bd4M-MDSCs\u6291\u5236\u80fd\u529b\u5c0f\u3002<\/p>\n

\u5728\u4eba\u7c7b\u4e0d\u540c\u7c7b\u578b\u7684\u764c\u75c7\u4e2d\uff0cPMN-MDSCs\u548cM-MDSCs\u4e4b\u95f4\u7684\u6bd4\u4f8b\u660e\u663e\u4e0d\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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MDSCs<\/strong>\u662f\u8377\u7624\u52a8\u7269\u548c\u60a3\u8005\u4f53\u5185\u7684\u4e3b\u8981\u514d\u75ab\u6291\u5236\u6210\u5206<\/strong>\u4e4b\u4e00\u3002\u56e0\u6b64\uff0cMDSCs\u7684\u6d88\u9664\u6216\u4f7f\u5176\u5206\u5316\u4e3a\u6709\u6548\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de<\/strong>\u662f\u514d\u75ab\u80bf\u7624\u5b66\u7684\u4e00\u4e2a\u4e3b\u8981\u95ee\u9898\u3002\u8fd9\u6837\u7684\u7b56\u7565\u53ef\u4ee5\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u529b\uff0c\u8ba9T\u7ec6\u80de\u653b\u51fb\u80bf\u7624\u7ec6\u80de\uff0c\u51cf\u8f7b\u80bf\u7624\u8d1f\u8377\u3002<\/p>\n

\u6211\u4eec\u5c06\u5728\u8fd9\u91cc\u96c6\u4e2d\u8ba8\u8bba\u73b0\u6709\u7684\u5404\u79cd\u51cf\u5c11MDSCs\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u5316\u7597\u548c\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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11.2 \u5316\u7597\u5bf9MDSCs\u7684\u5f71\u54cd<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u4e9b\u5316\u7597\u836f\u7269<\/strong>\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u76f4\u63a5\u6740\u6b7bMDSCs\u3002<\/p>\n

\u5409\u897f\u4ed6\u6ee8<\/strong>\uff08Gemcitabine\uff09\u662f\u4e00\u79cd\u5316\u7597\u836f\u7269\uff0c\u5176\u542b\u6709\u80de\u82f7\u7684\u6838\u82f7\u7c7b\u4f3c\u7269\uff0c\u8d77\u5230\u6297\u4ee3\u8c22\u7684\u4f5c\u7528\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u5404\u79cd\u764c\u75c7\uff0c\u5982\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\u3001\u80ba\u764c\u3001\u4e73\u817a\u764c\u548c\u80c6\u7ba1\u764c\u7b49\u3002<\/p>\n

2005\u5e74\uff0cSuzuki<\/strong>\u7b2c\u4e00\u6b21\u8bc1\u660e\u4e86\u4ee5\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u5316\u7597\u53ef\u4ee5\u9488\u5bf9MDSCs\u3002\u7528\u76f8\u5f53\u4e8e\u6cbb\u7597\u4eba\u7c7b\u75c5\u4eba\u7684\u7ecf\u5178\u5242\u91cf\u6cbb\u7597\u8377\u7624\u5c0f\u9f20\u7684\u7ed3\u679c\u8868\u660e\uff0c\u5409\u897f\u4ed6\u6ee8\u53ef\u9009\u62e9\u6027\u5730\u51cf\u5c11<\/strong>\u8377\u7624\u5c0f\u9f20\u813e\u810f\u4e2dMDSCs<\/strong>\u7684\u6570\u91cf\uff0c\u800c\u4e0d\u5f71\u54cdCD4\u7ec6\u80de\u3001CD8\u7ec6\u80de\u3001NK\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u6216B\u7ec6\u80de\u7684\u6570\u91cf\u548c\u529f\u80fd\u3002<\/p>\n

\u5409\u897f\u4ed6\u6ee8\u53ef\u63d0\u9ad8CD8+<\/sup>T\u7ec6\u80de\u548cNK\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4e14\u5bf9\u5c0f\u9f20\u813e\u810f\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u8f83\u5c0f\u3002\u7136\u800c\uff0c\u5355\u72ec\u4f7f\u7528\u5409\u897f\u4ed6\u6ee8\u5e76\u672a\u89c2\u5bdf\u5230\u5bf9\u80bf\u7624\u751f\u957f\u7684\u91cd\u5927\u5f71\u54cd\u3002<\/p>\n

2009\u5e74\uff0c\u53e6\u4e00\u4e2a\u4f7f\u7528\u4e0d\u540c\u80bf\u7624\u6a21\u578b\u7684\u7814\u7a76\u5c0f\u7ec4\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u7ed3\u679c\u3002\u9664\u4e86\u53d1\u73b0\u813e\u810f<\/strong>\u4e2dMDSC\u7684\u767e\u5206\u6bd4\u4e0b\u964d\u5916\uff0c\u4ed6\u4eec\u8fd8\u89c2\u5bdf\u5230\u9aa8\u9ad3\u548c\u5916\u5468\u8840\u6db2<\/strong>\u4e2d\u7684MDSC\u7684\u4e0b\u964d\u3002\u6cbb\u7597\u7ed9\u836f\u7684\u52a8\u529b\u5b66\u5c24\u4e3a\u91cd\u8981\u3002\u53ea\u6709\u65e9\u671f\u4f7f\u7528\u5409\u897f\u4ed6\u6ee8\u6cbb\u7597\u624d\u80fd\u5ef6\u7f13\u80bf\u7624\u751f\u957f\uff0c\u8fd9\u8868\u660e\u4ee3\u507f\u673a\u5236\u9650\u5236\u4e86\u5df2\u5efa\u7acb\u80bf\u7624\u4e2dMDSC\u6d88\u8017\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u591a\u897f\u7d2b\u6749\u9187\u548c\u7d2b\u6749\u9187<\/strong>\u662f\u4e34\u5e8a\u4e0a\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u7d2b\u6749\u9187\u5bb6\u65cf\u836f\u7269\u3002\u8fd9\u4e24\u79cd\u836f\u7269\u90fd\u9776\u5411\u5fae\u7ba1\u86cb\u767d<\/strong>\uff0c\u963b\u6b62\u5fae\u7ba1\u89e3\u805a\uff0c\u4ece\u800c\u963b\u6b62\u6709\u4e1d\u5206\u88c2<\/strong>\u3002<\/p>\n

\u591a\u897f\u7d2b\u6749\u9187\u662f\u4e00\u79cd\u5e38\u7528\u7684\u6297\u764c\u836f\u7269\uff0c\u572820\u4e16\u7eaa90\u5e74\u4ee3\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u4e73\u817a\u764c\u3002\u73b0\u5728\u7d2b\u6749\u9187\u88ab\u7528\u6765\u6cbb\u7597\u5404\u79cd\u764c\u75c7\uff0c\u5305\u62ec\u80ba\u764c\u3001\u6d88\u5316\u7cfb\u7edf\u764c\u548c\u5375\u5de2\u764c\u7b49\u3002<\/p>\n

\u591a\u897f\u7d2b\u6749\u9187\u88ab\u8bc1\u660e\u5bf9MDSCs\u6709\u5f71\u54cd<\/strong>\u3002\u643a\u5e26\u4e73\u817a\u80bf\u7624\u6a21\u578b4T1\u7684\u5c0f\u9f20\u7ecf\u591a\u897f\u7d2b\u6749\u9187\u6cbb\u7597\u540e\uff0c\u5176\u813e\u810f\u4e2d\u7684MDSCs<\/strong>\u660e\u663e\u51cf\u5c11\uff0cCTL\u5e94\u7b54\u66f4\u9ad8\u3002MDSCs\u7684\u51cf\u5c11\u90e8\u5206\u662f\u7531\u4e8e\u591a\u897f\u7d2b\u6749\u9187\u5bf9PMN-MDSCs\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528<\/strong>\uff0c\u800cM-MDSCs\u5206\u5316\u4e3aM1\u6837\u8868\u578b<\/strong>\u3002<\/p>\n

\u540e\u6765\u53d1\u73b0M-MDSCs\u5bf9\u591a\u897f\u7d2b\u6749\u9187\u5177\u6709\u8010\u836f\u6027<\/strong>\uff0c\u8fd9\u4e3b\u8981\u56e0\u4e3a\u5b83\u4eec\u5206\u6ccc\u578b\/\u80de\u6d46\u805a\u96c6\u7d20(sCLU)\u7684\u8868\u8fbe\uff0c\u800csCLU\u7684\u8868\u8fbe\u963b\u6b62\u4e86\u7d2b\u6749\u9187\u8bf1\u5bfc\u7684\u51cb\u4ea1\u7ea7\u8054\u53cd\u5e94\u3002<\/p>\n

\u591a\u897f\u7d2b\u6749\u9187\u7684\u7c7b\u4f3c\u7269\u7d2b\u6749\u9187<\/strong>\uff0c\u7ec6\u80de\u6bd2\u6d3b\u6027\u76f8\u5bf9\u8f83\u5f31\uff0c\u8fd9\u79cd\u836f\u7269\u4e5f\u4e3b\u8981\u7528\u4e8e\u80ba\u764c\u3001\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u7684\u6cbb\u7597\u3002\u4e0e\u672a\u6cbb\u7597\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5c0f\u5242\u91cf\u7d2b\u6749\u9187<\/strong>\u6cbb\u7597\u7684\u8377\u7624\u5c0f\u9f20\u7684MDSCs\u6570\u91cf\u51cf\u5c11\uff0c\u4f46\u65e0\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\u3002MDSC\u7684\u51cf\u5c11\u662f\u5176\u5206\u5316\u4e3aDC<\/strong>\u7684\u7ed3\u679c\uff0c\u5e76\u672a\u68c0\u6d4b\u5230MDSC\u7ec6\u80de\u6b7b\u4ea1\u3002\u540c\u4e00\u7814\u7a76\u5c0f\u7ec4\u5229\u7528\u81ea\u53d1\u6027\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u5b9e\u9a8c\uff0c\u7ed3\u679c\u663e\u793a\u4f4e\u5242\u91cf\u7684\u975e\u7ec6\u80de\u6bd2\u6027\u7d2b\u6749\u9187<\/strong>\u53ef\u4ee5\u51cf\u5c11MDSCs\u7684\u79ef\u7d2f\u53ca\u964d\u4f4e\u5176\u514d\u75ab\u6291\u5236\u6d3b\u6027(\u5176\u4f59MDSC\u4ea7\u751f\u7684TNF-\u03b1\u548cS100A9\u8f83\u5c11)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u963f\u9709\u7d20<\/strong>\uff08Doxorubicin\uff09\u662f\u4e00\u79cd\u5c5e\u4e8e\u84bd\u73af\u7c7b\u836f\u7269\u5bb6\u65cf\u7684\u5316\u7597\u836f\u7269\u3002\u5b83\u901a\u8fc7\u63d2\u5165\u548c\u6291\u5236\u62d3\u6251\u5f02\u6784\u9176II<\/strong>\u4e0eDNA\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6291\u5236DNA\u590d\u5236<\/strong>\u3002<\/p>\n

\u963f\u9709\u7d20\u901a\u5e38\u7528\u4e8e\u6cbb\u7597\u8089\u7624\u3001\u4e73\u817a\u764c\u3001\u767d\u8840\u75c5\u548c\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u5e76\u4e14\u5df2\u88ab\u8bc1\u660e\u80fd\u9009\u62e9\u6027\u5730\u8017\u5c3d<\/strong>4T1\u4e73\u817a\u764c\u8377\u7624\u5c0f\u9f20\u813e\u810f\u3001\u8840\u6db2\u548c\u80bf\u7624\u4e2dMDSCs<\/strong>\u3002\u6b8b\u7559\u7684MDSCs\u663e\u793a\u5176\u6291\u5236\u529f\u80fd\u53d7\u635f<\/strong>\uff0cROS\u3001\u7cbe\u6c28\u9178\u9176-1\u548cIDO<\/strong>\u7684\u4ea7\u751f\u8f83\u5c11\uff0c\u800cCD4\u548cCD8\u6dcb\u5df4\u7ec6\u80de\u548cNK\u7ec6\u80de\u7684\u6bd4\u4f8b\u8f83\u9ad8\u3002<\/p>\n

\u7136\u800c\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\u963f\u9709\u7d20\u4e5f\u80fd\u8bf1\u5bfc4T1\u7ec6\u80de\u7b49\u764c\u7ec6\u80de\u5206\u6ccc\u524d\u5217\u817a\u7d20E2<\/strong>(PGE2)\u3002\u524d\u5217\u817a\u7d20E2\u523a\u6fc0MDSC\u7684\u589e\u6b96\u548c\u79ef\u805a<\/strong>\uff0c\u5728\u8377\u7624\u5bbf\u4e3b\u4e2d\u91cd\u5efa\u540e\u7eed\u7684MDSC\u7fa4\u548c\u514d\u75ab\u6291\u5236\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u84bd\u73af\u7c7b\u836f\u7269\u5bf9MDSCs\u7684\u4f5c\u7528\u53ef\u80fd\u622a\u7136\u4e0d\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\u66f2\u8d1d\u66ff\u4e01<\/strong>\uff08Trabectedin\uff09\u662f\u4e00\u79cd\u7ec6\u80de\u6bd2\u5242\uff0c\u5b83\u7ed3\u5408\u5728DNA\u7684\u5c0f\u6c9f\u69fd<\/strong>\u4e0a\uff0c\u5f15\u8d77\u7ec6\u80de\u5468\u671f\u7684\u7d0a\u4e71<\/strong>\u3002<\/p>\n

\u5728\u4e0d\u540c\u7684\u5b9e\u9a8c\u6a21\u578b\u4e2d\uff0c\u66f2\u8d1d\u66ff\u4e01\u5bfc\u81f4\u8840\u6db2\u3001\u813e\u810f\u548c\u80bf\u7624\u4e2d\u7684\u5355\u6838\/\u5de8\u566c\u7ec6\u80de\u88ab\u9009\u62e9\u6027\u8017\u5c3d<\/strong>\uff0c\u5e76\u4f34\u968f\u7740\u8840\u7ba1\u751f\u6210\u7684\u51cf\u5c11\u3002\u7531\u4e8eTRAIL<\/strong>\u53d7\u4f53\uff08\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8bf1\u5bfc\u53d7\u4f53\uff09\u7684\u5dee\u5f02\u8868\u8fbe\uff0c\u66f2\u8d1d\u66ff\u4e01\u6fc0\u6d3b\u5355\u6838\u7ec6\u80de\u9ad3\u7cfb\u7ec6\u80de\u4e2dcaspase8\u4f9d\u8d56\u7684\u9009\u62e9\u6027\u51cb\u4ea1\uff0c\u800c\u4e0d\u662f\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2dcaspase8\u4f9d\u8d56\u7684\u9009\u62e9\u6027\u51cb\u4ea1\u3002\u8fd9\u4e9b\u6570\u636e\u663e\u793a\u51fa\u4f7f\u7528\u66f2\u8d1d\u66ff\u4e01\u9776\u5411\u80bf\u7624\u6d78\u6da6M-MDSCs\u7684\u53ef\u80fd\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
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\u5c40\u90e8\u653e\u7597<\/strong>\u53ef\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\uff0c\u6e05\u9664\u514d\u75ab\u6291\u5236\u7ec6\u80de\u3002\u5728CT26\u548cMC38\u5c0f\u9f20\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\uff0c\u9ad8\u5242\u91cf\u8f90\u5c04<\/strong>\u6539\u53d8\u4e86\u514d\u75ab\u6291\u5236\u7684\u80bf\u7624\u5fae\u73af\u5883\uff0c\u589e\u52a0CD8+<\/sup>T\u7ec6\u80de\u80bf\u7624\u7684\u6d78\u6da6\u4ee5\u53ca\u51cf\u5c11MDSC\u79ef\u805a<\/strong>\u3002\u4ece\u673a\u5236\u4e0a\u770b\uff0c\u653e\u7597\u8bf1\u5bfcCD8+<\/sup>T\u7ec6\u80de\u4ea7\u751fIFN-\u03b3<\/strong>\uff0c\u63a7\u5236\u4e86MDSCs\u5728\u80bf\u7624\u4e2d\u7684\u5b58\u6d3b\u548c\u6d78\u6da6\uff0c\u9006\u8f6c\u4e86\u514d\u75ab\u6291\u5236\u73af\u5883\u3002<\/p>\n

\u6b64\u5916\uff0c\u6297\u80bf\u7624\u514d\u75abCD8+<\/sup>T\u7ec6\u80de<\/strong>\u53ef\u901a\u8fc7\u4ea7\u751fTNF-\u03b1\u3001IFN-\u03b3\u6216\u8868\u8fbeFasL\u6765\u6740\u4f24MDSCs<\/strong>\uff0c\u4ece\u800c\u51cf\u5c11MDSC\u5728\u80bf\u7624\u4e2d\u7684\u6d78\u6da6\u3002\u76f8\u53cd\uff0c\u4f4e\u5242\u91cf\u653e\u7597\u5bf9MDSCs\u6570\u91cf\u65e0\u663e\u8457\u826f\u6027\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
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5-\u6c1f\u5c3f\u5627\u5576(5-FU)<\/strong>\u662f\u4e00\u79cd\u80f8\u82f7\u9178\u5408\u6210\u9176\u6291\u5236\u5242<\/strong>\uff0c\u53ef\u4ee5\u963b\u6b62DNA\u590d\u5236\u6240\u5fc5\u9700\u7684\u6838\u82f7\u80f8\u82f7\u7684\u5408\u6210\u3002\u8fd9\u79cd\u6297\u4ee3\u8c22\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u5927\u591a\u6570\u6d88\u5316\u7cfb\u7edf\u764c\u75c7\uff0c\u662f\u6cbb\u7597\u7ed3\u80a0\u764c\u7684\u4e3b\u8981\u836f\u7269\u3002<\/p>\n

\u5728\u51e0\u79cd\u5c0f\u9f20\u80bf\u7624\u6a21\u578b<\/strong>\u4e2d\uff0c5-FU\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u4f7fMDSCs\u8017\u7aed<\/strong>\uff0c\u5305\u62ecPMN-MDSCs\u548cM-MDSCs(<\/span>Fig. 11.1<\/span>)\u3002MDSC\u7684\u8017\u7aed\u662f\u7531\u4e8e5-FU\u6cbb\u7597\u540e\u89e6\u53d1\u7ec6\u80de\u51cb\u4ea1<\/strong>\u6240\u81f4\u30025-FU\u4e4b\u6240\u4ee5\u80fd\u9009\u62e9\u6027\u5730\u6740\u6b7bMDSCs\uff0c\u662f\u56e0\u4e3aMDSCs\u4f4e\u8868\u8fbe5-FU\u9776\u9176<\/strong>\uff08\u4e00\u79cd\u80f8\u82f7\u9178\u5408\u6210\u9176\uff09\u3002<\/p>\n

5-\u6c1f\u5c3f\u5627\u5576(5-FU)\u662f\u80f8\u82f7\u9178\u5408\u6210\u9176\u7684\u7ade\u4e89\u6027\u6291\u5236\u5242\uff0c\u80f8\u82f7\u9178\u5408\u6210\u9176\u4f4e\u8868\u8fbe\u7684\u7ec6\u80de\u5bf95-FU\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u975e\u5e38\u654f\u611f\u3002\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\uff0c5-FU\u6cbb\u7597\u663e\u8457\u5ef6\u7f13\u4e86\u80bf\u7624\u7684\u751f\u957f\uff0c\u5e76\u8bf1\u5bfc\u4e86\u80bf\u7624\u4e2d\u7279\u5f02\u6027CD8T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002<\/p>\n

\u4ed4\u7ec6\u89c2\u5bdf5-FU\u5bf9\u8377\u7624\u5c0f\u9f20\u514d\u75ab\u7fa4\u4f53\u7684\u5f71\u54cd\uff0c\u53d1\u73b0\u4f7f\u75285-FU\u6cbb\u759710\u5929\u540e\uff0cTh17\u7ec6\u80de<\/strong>\u6570\u91cf\u589e\u52a0\uff0c\u540c\u65f6\u80bf\u7624\u6062\u590d\u751f\u957f\u3002Th17\u7ec6\u80de\u7684\u589e\u52a0\u662f\u7531\u4e8e\u6b7b\u4ea1\u7684MDSCs\u4ea7\u751f\u4e86IL-1\u03b2<\/strong>\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c5-FU\u8bf1\u5bfcMDSCs\u4e2dBAX\u7684\u6fc0\u6d3b\u548c\u6eb6\u9176\u4f53\u7684\u901a\u900f\u6027\u589e\u52a0<\/strong>\u3002\u7ec4\u7ec7\u86cb\u767d\u9176B\u86cb\u767d\u4ece\u6eb6\u9176\u4f53\u91ca\u653e\u5230\u7ec6\u80de\u8d28\u4e2d\uff0c\u4e0eNLRP3\u76f8\u4e92\u4f5c\u7528\uff0c\u89e6\u53d1NLRP3\u708e\u6027\u5c0f\u4f53\u7684\u5f62\u6210\u548c\u6fc0\u6d3b\uff0c\u4ea7\u751f\u88c2\u89e3\u7684\u3001\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684IL-1\u03b2\u3002\u7136\u540e\uff0cIL-1\u03b2\u5c06\u4fc3\u8fdbCD4 T\u7ec6\u80de\u7684Th17\u6781\u5316\u3002\u7ecf5-FU\u5904\u7406\u7684MDSC\u4f53\u5916\u523a\u6fc0CD4T\u7ec6\u80de\u53ef\u4fc3\u8fdb\u5176\u4ea7\u751fIL-17\u7684\u80fd\u529b\u3002<\/p>\n

\u5728\u4f53\u5185\uff0c5-FU\u4ee5NLRP3\u4f9d\u8d56\u7684\u65b9\u5f0f\u8bf1\u5bfc\u8377\u7624\u5c0f\u9f20Th17\u7ec6\u80de\u805a\u96c6\u3002\u6709\u8da3\u7684\u662f\uff0cIL-17\u4fc3\u8fdb\u4e86\u8840\u7ba1\u751f\u6210\uff0c\u800c\u8fd9\u79cd\u65b0\u8840\u7ba1\u751f\u6210\u4f3c\u4e4e\u662f5-FU\u6709\u5bb3\u6548\u5e94\u7684\u91cd\u8981\u5f71\u54cd\u56e0\u7d20\u3002<\/p>\n

IL-1\u7684\u53ef\u6eb6\u6027\u53d7\u4f53IL-1RA\u4e0e5-FU\u8054\u5408\u4f7f\u7528\u53ef\u963b\u65adIL-1\u03b2\u7684\u4f5c\u7528\u3002\u8fd9\u79cd\u6cbb\u7597\u51cf\u5c11\u4e86Th17\u7ec6\u80de\u7684\u751f\u6210\u548c\u65b0\u751f\u8840\u7ba1\u7684\u751f\u6210\uff0c\u5e76\u663e\u8457\u63d0\u9ad8\u4e865-FU\u5bf9\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig. 11.1 <\/span>\uff1a5-FU\u4f9d\u8d56\u7684MDSCs\u8017\u7aed\u30025-FU\u7279\u5f02\u6027\u9776\u5411\u548c\u6d88\u8017MDSCs\uff0c\u964d\u4f4e\u6574\u4f53\u514d\u75ab\u6291\u5236\u3002\u7136\u800c\uff0c5-FU\u4e5f\u80fd\u8bf1\u5bfcMDSCs\u6eb6\u9176\u4f53\u7684\u901a\u900f\u6027\u589e\u52a0\u3002\u7136\u540e\uff0c\u7ec4\u7ec7\u86cb\u767d\u9176B\u53ef\u4ee5\u4ece\u6eb6\u9176\u4f53\u8fdb\u5165\u7ec6\u80de\u8d28\uff0c\u4e0eNLRP3\u76f8\u4e92\u4f5c\u7528\uff0c\u8bf1\u5bfcNLRP3\u708e\u75c7\u5c0f\u4f53\u7684\u5f62\u6210\u548c\u6fc0\u6d3b\u3002\u6fc0\u6d3b\u7684NLRP3\u708e\u75c7\u4f53\u5c06\u524dIL-1\u03b2\u88c2\u89e3\u4e3a\u6d3b\u6027IL-1\u03b2\uff0c\u6fc0\u6d3bCD4T\u7ec6\u80de\u4ea7\u751f\u66f4\u591aIL-17\uff0c\u4fc3\u8fdb\u65b0\u8840\u7ba1\u751f\u6210\u548c\u80bf\u7624\u751f\u957f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5316\u7597<\/strong>\u5bf9\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u5f71\u54cd\u5f80\u5f80\u662f\u4e00\u628a\u53cc\u5203\u5251<\/strong>\uff0c\u80bf\u7624\u7ec6\u80de\u548c\u514d\u75ab\u6291\u5236\u6027\u514d\u75ab\u7ec6\u80de\u64c5\u957f\u5bfb\u627e\u6f0f\u6d1e<\/strong>\uff0c\u4ece\u800c\u6062\u590d\u514d\u75ab\u6291\u5236\u6027\u80bf\u7624\u73af\u5883\uff0c\u5982\u56fe\u6240\u793a\u3002\u6211\u4eec\u5e94\u8be5\u5c0f\u5fc3\uff0c\u4e0d\u8981\u5728\u672a\u77e5\u5168\u8c8c\u4e4b\u524d\u505a\u51fa\u4efb\u4f55\u8fc7\u65e9\u7684\u7ed3\u8bba<\/strong>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n

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11.3 \u5316\u7597\u5bf9\u4ebaMDSCs\u7684\u5f71\u54cd<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u5173\u4e8e\u5316\u7597\u5bf9MDSCs\u5f71\u54cd\u7684\u4eba\u4f53\u7814\u7a76\u6709\u65f6\u4f1a\u663e\u793a\u51fa\u76f8\u4e92\u77db\u76fe<\/strong>\u7684\u6570\u636e\u3002<\/p>\n

\u5728\u80f0\u817a\u764c\u60a3\u8005<\/strong>\u4e2d\uff0c\u9996\u6b21\u663e\u793a5-FU\u548c\u5409\u897f\u4ed6\u6ee8\u964d\u4f4e\u4e86\u7ea640%\u7684\u60a3\u8005\u7684MDSCs\u767e\u5206\u6bd4\uff0c\u5e76\u4e14\u5f53\u4e0e\u4f7f\u7528GM-CSF\u4f5c\u4e3a\u4f50\u5242\u7684GV101\u75ab\u82d7\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u5927\u591a\u6570\u60a3\u8005\u7684MDSC\u767e\u5206\u6bd4\u964d\u4f4e\u3002\u4f46\u662f\uff0c\u4e00\u4e9b\u60a3\u8005\u7684MDSC\u6570\u91cf\u786e\u5b9e\u5347\u9ad8\u4e86\uff0c\u8fd9\u4e0e\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u7684\u589e\u52a0\u6709\u5173\u3002<\/p>\n

\u8fd9\u4e9b\u7ed3\u679c\u4e0e\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u76f8\u543b\u5408\uff0c\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u5409\u897f\u4ed6\u6ee8\u62165-FU\u6cbb\u7597\u4e0e\u80bf\u7624\u7ec6\u80de\u5206\u6ccc\u7684GM-CSF\u4e0a\u8c03\u6709\u5173\uff0c\u7531\u6b64\u8bf1\u5bfcMDSCs\u5411\u5355\u6838\u7ec6\u80de\u5206\u5316\u3002<\/p>\n

\u76f8\u53cd\uff0c\u5409\u897f\u4ed6\u6ee8\u548c5-\u6c1f\u5c3f\u5627\u5576\u8054\u5408\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u7684\u6740\u4f24\u7ec6\u80de\u7684\u514d\u75ab\u6cbb\u7597\u65f6\uff0c\u89c2\u5bdf\u5230\u5bf9MDSCs\u6709\u79ef\u6781\u4f5c\u7528\u3002<\/p>\n

\u5728\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u548c\u80f0\u817a\u764c<\/strong>\u4e2d\uff0c\u8fd9\u79cd\u5316\u7597\u7ed3\u5408\u514d\u75ab\u7597\u6cd5\u7684\u4f7f\u7528\u6210\u529f\u5730\u51cf\u5c11\u4e86\u60a3\u8005\u5916\u5468\u8840\u4e2dMDSCs\u7684\u6570\u91cf\uff0c\u5ef6\u957f\u4e86\u751f\u5b58\u65f6\u95f4\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u5728\u7ed3\u76f4\u80a0\u764c\u60a3\u8005<\/strong>\u4e2d\uff0c5-FU\u6cbb\u7597\u7684\u9633\u6027\u6216\u9634\u6027\u7ed3\u679c\u53d6\u51b3\u4e8e\u4e0e5-FU\u8054\u5408\u4f7f\u7528\u7684\u7c7b\u578b\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c5-FU\u5e76\u4e0d\u662f\u5355\u72ec\u7528\u4e8e\u7ed3\u76f4\u80a0\u764c\u30025-FU\u4e0e\u53f6\u9178\u548c\u5965\u6c99\u5229\u94c2(FOLFOX)\u8054\u5408\u4f7f\u7528\u88ab\u8bc1\u660e\u662f\u6709\u76ca\u7684\uff0c\u53ef\u4ee5\u964d\u4f4e\u603b\u4f53\u514d\u75ab\u6291\u5236\u548cMDSC\u767e\u5206\u6bd4\uff0c\u800c5-FU\u4e0e\u53f6\u9178\u548cCPT11(FOLFIRI)\u8054\u5408\u4f7f\u7528\u5219\u662f\u6709\u5bb3\u7684\uff0c\u751a\u81f3\u589e\u52a0\u4e86\u60a3\u8005\u4e2dMDSCs\u7684\u6570\u91cf\u3002<\/p>\n

\u5728\u53e6\u4e00\u9879\u6d4b\u8bd5FOLFOX\u8054\u5408\u8d1d\u4f10\u5355\u6297\uff08\u4e00\u79cd\u6297VEGF-A\u6297\u4f53\uff09\u5bf9\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e00\u7ebf\u6cbb\u7597\u60a3\u8005MDSCs\u5f71\u54cd\u7684\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u89c2\u5bdf\u523025\u540d\u60a3\u8005\u4e2d\u670915\u540dPMN-MDSCs\u4e0b\u964d\u3002<\/p>\n

\u7531\u4e8e\u764c\u75c7\u5316\u7597\u603b\u662f\u4e0e\u51e0\u79cd\u836f\u7269\u8054\u5408\u5728\u4e00\u8d77\uff0c\u56e0\u6b64\u7814\u7a76\u8fd9\u4e9b\u8054\u7cfb\u7684\u6548\u679c\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n

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11.4 \u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9664\u4e86\u7ec6\u80de\u6bd2\u6027\u5316\u7597\u5916\uff0c\u8fd8\u7814\u7a76\u4e86\u5176\u4ed6\u51e0\u7c7b\u6297\u764c\u836f\u7269\u963b\u6b62MDSC\u7684\u589e\u6b96\u6216\u4fc3\u8fdb\u5176\u5206\u5316\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
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\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242(TKIs)<\/strong>\u662f\u4e00\u7ec4\u9488\u5bf9\u4e0d\u540c\u9014\u5f84\u7684\u916a\u6c28\u9178\u6fc0\u9176\u7684\u5206\u5b50\u3002\u9776\u5411\u8c03\u8282 RAS-RAF\/MAPK\u901a\u8def\u3001PI3K\/AKT\/mTOR \u901a\u8def\u548cEGFR\u901a\u8def<\/strong>\uff0c\u53c2\u4e0e\u8c03\u8282\u7ec6\u80de\u7684\u5b58\u6d3b\u3001\u589e\u6b96\u3001\u5206\u5316\u548c\u8fc1\u79fb\u4ee5\u53ca\u8840\u7ba1\u751f\u6210<\/strong>\u3002\u8fd9\u4e9b\u9014\u5f84\u7684\u7a81\u53d8\u7ecf\u5e38\u5728\u764c\u75c7\u4e2d\u88ab\u53d1\u73b0\uff0c\u8fd9\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u5173\u4e8eTKI\u7684\u7814\u7a76\u5728\u8fc7\u53bb\u51e0\u5e74\u6709\u5feb\u901f\u4e14\u6301\u7eed\u7684\u53d1\u5c55\u3002TKIs\u5bf9MDSCs\u7684\u6f5c\u5728\u5f71\u54cd\u5f15\u8d77\u4e86\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8212\u5c3c\u66ff\u5c3c\uff08Sunitinib\uff09<\/strong>\u662f\u4e00\u79cd\u9488\u5bf9\u591a\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff08RTKs\uff09\u7684TKI\uff0c\u5305\u62ecVEGF-R1\u548cVEGF-R2\uff0cPDGF-Rs<\/strong>\uff0c\u4e5f\u5305\u62ecc-kit<\/strong>\u3002\u5b83\u4e8e2007\u5e74\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c<\/strong>(RCC)\uff0c\u76ee\u524d\u7528\u4e8eRCC\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/p>\n

\u5728\u80be\u764c\u4e2d\uff0c\u8212\u5c3c\u66ff\u5c3c\u901a\u8fc7\u5f71\u54cdMDSC\u7684\u5b58\u6d3b\u7387\u548c\u589e\u6b96<\/strong>\u6765\u9006\u8f6cMDSC\u7684\u79ef\u805a\u3002MDSC\u7684\u51cf\u5c11\u4e0eCD3\u7ec6\u80de\u4ea7\u751fIFN-\u03b3<\/strong>\u7684\u589e\u52a0\u6709\u5173\u3002\u8212\u5c3c\u66ff\u5c3c\u53ef\u51cf\u5c11MDSCs\u548cTregs<\/sub>\u7684\u6570\u91cf<\/strong>\uff0c\u51cf\u5c11\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50IL-10\u3001TGF-\u03b2\u7684\u4ea7\u751f\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u7ecf\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u540e\uff0cCD4\u548cCD8T\u7ec6\u80de\u4e0a\u8d1f\u6027\u5171\u523a\u6fc0\u5206\u5b50CTLA-4\u548cPD-1\u7684\u8868\u8fbe\u51cf\u5c11<\/strong>\u3002\u8212\u5c3c\u66ff\u5c3c\u53ef\u6291\u5236\u5355\u6838MDSC\u7684\u589e\u6b96<\/strong>\uff0c\u540c\u65f6\u8bf1\u5bfc\u7c92\u7ec6\u80deMDSC\u4e9a\u7fa4\u51cb\u4ea1<\/strong>\u3002<\/p>\n

\u7136\u800c\uff0c\u80bf\u7624\u5185MDSC\u7684\u6570\u91cf\u548c\u529f\u80fd\u4e0d\u53d7\u8212\u5c3c\u66ff\u5c3c\u7684\u5f71\u54cd\uff0c\u56e0\u4e3a\u5728\u80bf\u7624\u4e2d\u4ea7\u751f\u7684\u5927\u91cf\u7684GM-CSF\u4ee5STAT5\u4f9d\u8d56\u7684\u9014\u5f84\u4fdd\u62a4MDSCs<\/strong>\u3002<\/p>\n

\u636e\u62a5\u9053\uff0c\u8212\u5c3c\u66ff\u5c3c\u8fd8\u53ef\u4ee5\u5f71\u54cdMDSCs\u4ee5\u5916\u7684\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\uff0c\u56e0\u4e3a\u53ef\u4ee5\u89c2\u5bdf\u5230\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u964d\u4f4e\uff0c\u800c\u6dcb\u5df4\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u589e\u52a0(Fig 11.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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Fig. 11.2 <\/span>\uff1a\u8212\u5c3c\u66ff\u5c3c\u7684\u514d\u75ab\u6548\u679c\u3002Sunitinib\u662f\u4e00\u79cd\u9488\u5bf9VEGF-Rs\u548cPDGF-Rs\u7684TKI\uff0c\u901a\u8fc7\u964d\u4f4eMDSC\u7684\u6d3b\u6027\u548c\u589e\u6b96\u6765\u6291\u5236MDSC\u7684\u805a\u96c6\u3002\u8212\u5c3c\u66ff\u5c3c\u8fd8\u53ef\u9776\u5411Tregs<\/sub>\uff0c\u51cf\u5c11IL-10\u548cTGF-\u03b2\u7684\u4ea7\u751f\uff0c\u540c\u65f6\u4fc3\u8fdbCD4\u548cCD8T\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u589e\u52a0 IFN-\u03b3\u7684\u4ea7\u751f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u800c\u4f7f\u7528\u53e6\u4e00\u79cdVEGF\u901a\u8def\u6291\u5236\u5242\u8d1d\u4f10\u5355\u6297<\/strong>(\u6297VEGF-A\u5355\u6297)\u7684\u7814\u7a76\u8868\u660e\uff0cMDSCs\u662f\u5bfc\u81f4\u6297VEGF\u6cbb\u7597\u4e34\u5e8a\u6548\u679c\u4e0d\u4f73\u7684\u539f\u56e0\uff0c\u4f46\u8d1d\u4f10\u5355\u6297\u5bf9MDSC\u7684\u6d3b\u6027\u6216\u5206\u5316\u6ca1\u6709\u5f71\u54cd\u3002<\/p>\n

\u540e\u6765\u7684\u53e6\u4e00\u9879\u7814\u7a76\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u70b9\uff0c\u8be5\u7814\u7a76\u8868\u660e\u8d1d\u4f10\u5355\u6297\u6cbb\u7597\u4e0d\u4f1a\u964d\u4f4eMDSCs\u7684\u767e\u5206\u6bd4\uff0c\u4e5f\u4e0d\u4f1a\u6539\u53d8\u5176\u7cbe\u6c28\u9178\u9176-1\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u4f46\u662f\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u4e09\u4e2a\u5468\u671f\u7684\u8d1d\u4f10\u5355\u6297\u8054\u5408\u5316\u7597\u65b9\u6848\u53ef\u4ee5\u4ee5\u8d1d\u4f10\u5355\u6297\u4f9d\u8d56\u7684\u65b9\u5f0f\u51cf\u5c11PMN-MDSC\u7684\u6570\u91cf\u3002<\/p>\n

\u8d1d\u4f10\u5355\u6297\u5bf9MDSCs\u7684\u5f71\u54cd\u4ecd\u6709\u5f85\u8bc1\u5b9e\uff0c\u89c2\u5bdf\u5230\u7684\u5dee\u5f02\u53ef\u80fd\u662f\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u7684\u5176\u4ed6\u836f\u7269\u7684\u7ed3\u679c\uff0c\u4e5f\u53ef\u80fd\u662f\u7531\u4e8e\u80bf\u7624\u7c7b\u578b\u7684\u4e0d\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7d22\u62c9\u975e\u5c3c\uff08Sorafenib\uff09<\/strong>\u662f\u4e00\u79cd\u9488\u5bf9\u591a\u79cd\u6fc0\u9176\u7684\u6291\u5236\u5242\uff0c\u5176\u4e2d\u5305\u62ecC-RAF\u3001BRAF\u3001VEGF-R2\u548cVEGF-R3<\/strong>\u3002<\/p>\n

\u7d22\u62c9\u975e\u5c3c\u5728\u5c0f\u9f20\u809d\u764c\u6a21\u578b<\/strong>\u4e2d\u9996\u6b21\u88ab\u8bc1\u660e\u80fd\u591f\u51cf\u5c11Tregs<\/sub>\u548cMDSCs<\/strong>\uff0c\u540c\u65f6\u51cf\u7f13\u4e86\u80bf\u7624\u7684\u751f\u957f\u3002\u6b64\u5916\uff0c\u7d22\u62c9\u975e\u5c3c\u80fd\u964d\u4f4eMDSCs\u5bf9CD8T\u7ec6\u80de\u7684\u6291\u5236<\/strong>\uff0c\u800c\u53e6\u4e00\u79cd\u6291\u5236\u5242\u8212\u5c3c\u66ff\u5c3c\u5219\u4e0d\u80fd\u3002<\/p>\n

\u5bf9\u4e0d\u540c\u5242\u91cf\u7684\u4e0d\u540c\u7ed9\u836f\u65b9\u6848\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u91cd\u590d\u5c0f\u5242\u91cf\u7684\u7d22\u62c9\u975e\u5c3c<\/strong>\u4f3c\u4e4e\u901a\u8fc7\u51cf\u5c11MDSCs\u548cTreg<\/sub><\/strong>\u7ec6\u80de\u6570\u91cf\uff0c\u4ee5\u53ca\u901a\u8fc7\u51cf\u5c11IL-10\u6216TGF-\u03b2<\/strong>\u7b49\u514d\u75ab\u6291\u5236\u5206\u5b50\u7684\u8868\u8fbe\u6765\u589e\u5f3a\u8fc7\u7ee7T\u7ec6\u80de\u6cbb\u7597\u7684\u7597\u6548\u3002<\/p>\n

\u5728\u9009\u62e9\u5242\u91cf\u7684\u540c\u65f6\uff0c\u8fd8\u5e94\u8003\u8651\u6cbb\u7597\u7684\u52a8\u529b\u5b66\uff0c\u56e0\u4e3a\u7d22\u62c9\u975e\u5c3c\u53ef\u4ee5\u964d\u4f4e\u5355\u6838\u7ec6\u80de\u6765\u6e90\u7684MDSC\u7684\u6bd4\u4f8b\uff0c\u4f46\u4e0d\u5f71\u54cd\u5df2\u7ecf\u5206\u5316\u7684MDSCs<\/strong>\u3002 <\/p>\n

\u7136\u800c\uff0c\u7d22\u62c9\u975e\u5c3c\u7684\u4f5c\u7528\u53ef\u80fd\u5e76\u4e0d\u5c40\u9650\u4e8eMDSCs\u3002\u7d22\u62c9\u975e\u5c3c\u5728IL-2\u6216IFN-\u03b1<\/strong>\u523a\u6fc0\u540e\u964d\u4f4e\u4e86T\u7ec6\u80de\u3001B\u7ec6\u80de\u3001NK\u7ec6\u80de\u3001Tregs<\/sub>\u548cMDSCs\u4e2dSTAT1\u548cSTAT5<\/strong>\u7684\u78f7\u9178\u5316\u3002<\/p>\n

\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u7d22\u62c9\u975e\u5c3c\u53ef\u80fd\u4f1a\u5bf9\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u6548\u5e94\u7ec6\u80de\u4ea7\u751f\u6709\u5bb3\u5f71\u54cd<\/strong>\u3002\u5728\u4f7f\u7528\u7d22\u62c9\u975e\u5c3c\u8017\u7aedMDSCs\u65f6\uff0c\u6211\u4eec\u53ef\u80fd\u5e94\u8be5\u7262\u8bb0\u8fd9\u4e9b\u6570\u636e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9488\u5bf9c-kit\u548cBCR-ABL\uff0c\u4f0a\u9a6c\u66ff\u5c3c\uff08imatinib\uff09<\/strong>\u662f\u7b2c\u4e00\u4e2a\u88ab\u6279\u51c6\u7528\u4e8e\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5<\/strong>\u7684TKI\u3002<\/p>\n

\u4f0a\u9a6c\u66ff\u5c3c\u6709\u6548\u6291\u5236MDSC\u589e\u6b96\u548c\u7cbe\u6c28\u9178\u9176-1\u8868\u8fbe<\/strong>\u3002\u7136\u800c\uff0c\u5173\u4e8e\u5b83\u5bf9\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u7fa4\u4f53\u7684\u5f71\u54cd\uff0c\u5404\u79cd\u62a5\u544a\u4e5f\u63d0\u5230\u4e86\u76f8\u4e92\u77db\u76fe<\/strong>\u7684\u7ed3\u679c\u3002<\/p>\n

\u4f0a\u9a6c\u66ff\u5c3c\u88ab\u8bc1\u660e\u53ef\u4ee5\u524a\u5f31Tregs<\/sub>\u514d\u75ab\u6291\u5236\u529f\u80fd<\/strong>\uff0c\u6062\u590d\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de<\/strong>\u529f\u80fd\uff0c\u5e76\u6291\u5236\u80bf\u7624\u8bf1\u5bfc\u7684CD4+<\/sup>T\u7ec6\u80de\u8010\u53d7<\/strong>\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u4f0a\u9a6c\u66ff\u5c3c\u6cbb\u7597\u4e5f\u88ab\u8bc1\u660e\u53ef\u4ee5\u963b\u6b62\u7ecf\u6297\u539f\u6d3b\u5316\u540eCD8T\u7ec6\u80de\u7684\u6269\u589e<\/strong>\uff0c\u800c\u4e0d\u5f71\u54cd\u4e3b\u8981\u7684T\u7ec6\u80de\u548cB\u7ec6\u80de\u7684\u53cd\u5e94\u3002<\/p>\n

\u8fbe\u6c99\u66ff\u5c3c\uff08Dasatinib \uff09<\/strong>\u662f\u7b2c\u4e8c\u4ee3\u5316\u5408\u7269\uff0c\u7528\u4e8e\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u65e0\u6548\u7684\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u60a3\u8005\u3002\u4e0e\u4f0a\u9a6c\u66ff\u5c3c\u4e00\u6837\uff0c\u8fbe\u6c99\u66ff\u5c3c\u963b\u65ad\u4e86MDSC\u7684\u6269\u589e\uff0c\u5e76\u4e14\u5f53\u4e0e\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\u7684DC\u75ab\u82d7\u8054\u5408\u65f6\uff0c\u53ef\u4ee5\u5f15\u53d1\u5e7f\u6cdb\u7684\u80bf\u7624\u76f8\u5173CD8+<\/sup>\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684\u53d1\u80b2\u3002<\/p>\n

\u7136\u800c\uff0c\u5728\u51e0\u9879\u7814\u7a76\u4e2d\uff0c\u8fbe\u6c99\u66ff\u5c3c\u4e5f\u4ee5\u5242\u91cf\u4f9d\u8d56\u7684\u65b9\u5f0f\u6291\u5236CD4+<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u589e\u6b96<\/strong>\u3002<\/p>\n

\u4f0a\u9a6c\u66ff\u5c3c\u548c\u8fbe\u6c99\u66ff\u5c3c\u5bf9MDSCs\u7684\u6709\u76ca\u4f5c\u7528\u662f\u660e\u786e\u7684\uff0c\u4f46\u5b83\u4eec\u5bf9T\u7ec6\u80de\u7684\u5f71\u54cd\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bb8\u591a\u5176\u4ed6\u7684TKI\u5df2\u88ab\u8bc1\u660e\u5bf9MDSCs\u5176\u589e\u6b96\u3001\u5206\u5316\u4ee5\u53ca\u5176\u6291\u5236\u529f\u80fd\u6709\u8f83\u5927\u5f71\u54cd\u3002<\/p>\n

2011\u5e74\uff0cFDA\u6279\u51c6\u7ef4\u83ab\u62c9\u975e\u5c3c\uff08Vemurafenib\uff09<\/strong>\u901a\u8fc7BRAF V600\u7a81\u53d8\u6cbb\u7597\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002\u7ef4\u83ab\u62c9\u975e\u5c3c<\/strong>\u53ef\u964d\u4f4e\u5c0f\u9f20\u548c\u4eba\u9ed1\u8272\u7d20\u7624\u4e2dM-MDSCs\u3001PMN-MDSCs\u548cTregs<\/sub>\u7684\u6bd4\u4f8b\u548c\u6570\u91cf\u3002\u4f7f\u7528\u7ef4\u83ab\u62c9\u975e\u5c3c\u6cbb\u7597\u540e\uff0c\u89c2\u5bdf\u5230\u80bf\u7624\u6d78\u6da6\u6027CD8T\u7ec6\u80de\u589e\u52a0\uff0c\u5e76\u4e14\u8fd9\u4e0e\u80bf\u7624\u7f29\u5c0f\u6709\u5173\u3002<\/p>\n

\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176(BTK)\u6291\u5236\u5242\u4f9d\u9c81\u66ff\u5c3c\uff08ibrutinib\uff09<\/strong>\u4e8e2013\u5e74\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u4e00\u4e9bB\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u5b83\u53ef\u4ee5\u51cf\u5c11MDSC\u5728\u80bf\u7624\u533a\u57df\u7684\u79ef\u805a\uff0c\u5e76\u51cf\u5c11IDO\u7684\u8868\u8fbe\u3002\u8fd9\u4e9b\u6548\u5e94\u5f88\u53ef\u80fd\u662f\u6291\u5236MDSCs\u4e2dBTK\u7684\u76f4\u63a5\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u8fd1\uff0c\u4eba\u4eec\u5bf9PI3K\/AKT\/mTOR\u901a\u8def<\/strong>\u5bf9MDSCs\u7684\u5f71\u54cd\u8d8a\u6765\u8d8a\u611f\u5174\u8da3\u3002\u80bf\u7624\u7ec6\u80de\u548cMDSCs\u7684mTOR\u901a\u8def\u7684\u6fc0\u6d3b\u4f3c\u4e4e\u90fd\u6709\u5229\u4e8eMDSCs\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0cmTOR\u6291\u5236\u5242\u96f7\u5e15\u9709\u7d20\uff08rapamycin\uff09<\/strong>\u5df2\u88ab\u8bc1\u660e\u80fd\u663e\u8457\u964d\u4f4e\u8377\u7624\u5c0f\u9f20\u7684MDSC\u6570\u91cf\u548cM-MDSC\u7684\u514d\u75ab\u6291\u5236<\/strong>\u7684\u529f\u80fd<\/strong>\u3002mTOR\u4f3c\u4e4e\u662f\u5f71\u54cdMDSCs\u5206\u5316\u548c\u6291\u5236\u529f\u80fd\u7684\u5185\u5728\u56e0\u7d20\u3002<\/p>\n

\u6b64\u5916\uff0c\u764c\u7ec6\u80de\u4e2dmTOR\u901a\u8def\u7684\u6fc0\u6d3b\u4e5f\u53ef\u80fd\u6709\u5229\u4e8eMDSCs\u5728\u4eba\u4e73\u817a\u764c\u4e2d\u4ee5G-CSF\u4f9d\u8d56<\/strong>\u7684\u65b9\u5f0f\u52df\u96c6\u548c\u79ef\u805a\u3002<\/p>\n

\u7136\u800c\uff0c\u6211\u4eec\u5fc5\u987b\u8bb0\u4f4f\uff0cmTOR\u6fc0\u6d3b\u4e5f\u662fT\u7ec6\u80de\u6fc0\u6d3b\u6240\u5fc5\u9700\u7684\uff0cmTOR\u6291\u5236\u5242\u53ef\u80fd\u4f1a\u5bf9CD8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4ea7\u751f\u4e00\u4e9b\u6709\u5bb3\u7684\u5f71\u54cd<\/strong>\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4e34\u5e8a\u4e0a\u4ec5\u6709\u96f7\u5e15\u9709\u7d20\u884d\u751f\u7269\u7528\u4e8e\u963b\u65adPI3K\/AKT\/mTOR\u901a\u8def\uff0c\u4f46\u5176\u4ed6\u9488\u5bf9\u8be5\u901a\u8def\u7684\u6291\u5236\u5242\u4ecd\u5728\u5f00\u53d1\u4e2d\u3002\u8fd9\u7c7b\u836f\u7269\u4e5f\u5e94\u8be5\u8fdb\u884c\u6d4b\u8bd5\uff0c\u4ee5\u660e\u786e\u5b83\u4eec\u6291\u5236MDSCs\u7684\u529f\u80fd\u6216\u51cf\u5c11\u5176\u6570\u91cf\u7684\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/section>\n
f<\/span>or Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 | M\u00e9lanie Bruchard and Francois Ghiringhelli<\/span><\/section>\n
\u7ffb\u8bd1 |   \u7ae0\u9707  \u949f\u96ea\u83b9 \u8d75\u6db5<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u9648\u8389\u8679<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u4efb\u632f\u9633 \u5ed6<\/span>\u5a9b<\/span><\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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\u2589  OncoLab\u5b66\u672f\u5bfc\u822a<\/strong><\/strong><\/p>\n

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\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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