{"id":4633,"date":"2022-10-11T09:43:04","date_gmt":"2022-10-11T01:43:04","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2022\/10\/11\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac34%e7%ab%a0%ef%bc%9a%e7%a7%bb%e6%a4%8d\/"},"modified":"2022-10-11T09:43:04","modified_gmt":"2022-10-11T01:43:04","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac34%e7%ab%a0%ef%bc%9a%e7%a7%bb%e6%a4%8d","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2022\/10\/11\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac34%e7%ab%a0%ef%bc%9a%e7%a7%bb%e6%a4%8d\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c34\u7ae0\uff1a\u79fb\u690d"},"content":{"rendered":"
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\u672c\u7ae0\u4e3b\u8981\u4ecb\u7ecd\u5668\u5b98\u79fb\u690d\u7684\u751f\u7269\u5b66\u76f8\u5173\u77e5\u8bc6\uff0c\u4ee5\u53ca\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u4e3a\u4f55\u4f1a\u4f7f\u5f97\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u548c\u5e72\u7ec6\u80de\u79fb\u690d(SCT)\u53d8\u5f97\u66f4\u52a0\u56f0\u96be\u3002\u672c\u7ae0\u8fd8\u4ecb\u7ecd\u4e86\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5(GVHD)\u662fSCT\u989d\u5916\u7684\u5e76\u53d1\u75c7\uff0c\u4ee5\u53ca\u5982\u4f55\u4f7f\u7528\u7ec4\u7ec7\u5206\u578b\u6280\u672f\u548c\u514d\u75ab\u6291\u5236\u5242\u6765\u964d\u4f4e\u8fd9\u4e9b\u5e76\u53d1\u75c7\u53d1\u751f\u7684\u98ce\u9669\u3002\u6700\u540e\uff0c\u672c\u7ae0\u5bf9\u4e8e\u5c06\u5f02\u79cd\u79fb\u690d\u4f5c\u4e3a\u4e00\u79cd\u6709\u6548\u7684\u66ff\u4ee3\u6cbb\u7597\u65b9\u6cd5\u6240\u9700\u8981\u514b\u670d\u7684\u4e00\u4e9b\u95ee\u9898\u8fdb\u884c\u4e86\u6982\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7ae0\u76f8\u5173\u672f\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7b2c 8 \u7ae0<\/span>\u4e2d<\/span>\u9996\u6b21\u63d0\u5230\u4ee5\u4e0b\u672f\u8bed\uff1a<\/p>\n

\u2022 \u6392\u65a5\u53cd\u5e94(Rejection)\uff1a\u60a3\u8005\u5728\u63a5\u53d7\u79fb\u690d\u624b\u672f\u540e\uff0c\u673a\u4f53\u4ea7\u751f\u7684\u4e00\u7cfb\u5217\u514d\u75ab\u5e94\u7b54\uff0c\u901a\u5e38\u4f1a\u5bf9\u79fb\u690d\u5668\u5b98\u9020\u6210\u4e00\u5b9a\u7684\u635f\u5bb3\u3002<\/p>\n

\u2022 \u81ea\u4f53\u79fb\u690d(Autologous transplant)\uff1a\u81ea\u8eab\u7ec4\u7ec7\u5728\u4f53\u5916\u4e00\u6bb5\u65f6\u95f4\u540e(\u901a\u5e38\u5904\u4e8e\u51b7\u51bb\u72b6\u6001)\u518d\u91cd\u65b0\u690d\u5165\u8be5\u4e2a\u4f53\u4f53\u5185\u3002<\/p>\n

\u2022 \u540c\u57fa\u56e0\u79fb\u690d(Syngeneic transplant)\uff1a\u540c\u5375\u53cc\u80de\u80ce\u4e4b\u95f4\u7684\u79fb\u690d\uff0c\u8fd9\u79cd\u60c5\u51b5\u901a\u5e38\u4e0d\u4f1a\u53d1\u751f\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n

\u2022 \u5f02\u57fa\u56e0\u79fb\u690d(Allogeneic transplant)\uff1a\u53d1\u751f\u5728\u540c\u4e00\u7269\u79cd\u4e2d\u5177\u6709\u4e0d\u540c\u57fa\u56e0\u7684\u4e0d\u540c\u6210\u5458\u4e4b\u95f4\uff0c\u8fd9\u79cd\u79fb\u690d\u5f80\u5f80\u5b58\u5728\u53d1\u751f\u6392\u65a5\u53cd\u5e94\u7684\u98ce\u9669\u3002<\/p>\n

\u2022 \u5c38\u4f53\u79fb\u690d(Cadaveric transplantation)\uff1a\u4f7f\u7528\u6b7b\u4ea1\u6350\u8d60\u8005\u7684\u5668\u5b98\u3002<\/p>\n

\u2022 \u5f02\u79cd\u79fb\u690d(Xenogeneic transplant)\uff1a\u53d1\u751f\u5728\u4e0d\u540c\u7269\u79cd\u4e4b\u95f4\uff0c\u6392\u65a5\u98ce\u9669\u6700\u9ad8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b9e\u4f53\u5668\u5b98\u79fb\u690d<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ec0\u4e48\u60c5\u51b5\u4e0b\u53ef\u4ee5\u8fdb\u884c\u5668\u5b98\u79fb\u690d\uff1f<\/p>\n<\/section>\n

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\u5f53\u67d0\u4e9b\u5b9e\u4f53\u5668\u5b98\u505c\u6b62\u8fd0\u4f5c\u65f6\uff0c\u53ef\u80fd\u8003\u8651\u5c06\u79fb\u690d\u4f5c\u4e3a\u4e00\u79cd\u6cbb\u7597\u624b\u6bb5\uff0c\u800c\u79fb\u690d\u524d\u5fc5\u987b\u6ee1\u8db3\u51e0\u4e2a\u6761\u4ef6:<\/p>\n

\u2022 \u5fc5\u987b\u786e\u4fdd\u635f\u4f24\u662f\u4e0d\u53ef\u9006\u7684\u6216\u4e0d\u9002\u7528\u4e8e\u66ff\u4ee3\u6cbb\u7597\u3002<\/p>\n

\u2022 \u75be\u75c5\u4e0d\u80fd\u590d\u53d1\uff0c\u4f8b\u5982\uff0c\u6709\u6297\u80be\u5c0f\u7403\u57fa\u5e95\u819c\u6297\u4f53\u7684Goodpasture\u7efc\u5408\u5f81\u60a3\u8005\u5c31\u4e0d\u80fd\u8fdb\u884c\u80be\u79fb\u690d(\u7b2c29\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u8fd8\u5fc5\u987b\u5c3d\u91cf\u51cf\u5c11\u4ea7\u751f\u6392\u65a5\u53cd\u5e94\u7684\u53ef\u80fd\u6027:<\/p>\n

\u2022 \u4f9b\u4f53\u548c\u53d7\u4f53\u7684ABO\u8840\u578b\u5fc5\u987b\u76f8\u5bb9\u3002<\/p>\n

\u2022 \u63a5\u53d7\u8005\u4e0d\u5f97\u542b\u6709\u6297\u4f9b\u4f53\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f(HLA)\u7684\u6297\u4f53\u3002<\/p>\n

\u2022 \u6350\u732e\u8005\u4e0e\u63a5\u53d7\u8005\u7684HLA\u5339\u914d\u5ea6\u5e94\u5c3d\u53ef\u80fd\u9ad8\u3002<\/p>\n

\u2022 \u60a3\u8005\u5fc5\u987b\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u9762\u4e34\u7684\u4e3b\u8981\u95ee\u9898\u662f\u6392\u65a5\u53cd\u5e94\uff0c\u6700\u5e38\u89c1\u7684\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u7c7b\u578b\u2014\u2014\u80be\u79fb\u690d\uff0c\u5c31\u662f\u4e00\u4e2a\u4f8b\u5b50\u3002\u5982Table 34.1<\/span>\u6240\u793a\uff0c\u4e0d\u540c\u7684\u5668\u5b98\u79fb\u690d\u624b\u672f\uff0c\u64cd\u4f5c\u4e5f\u4e0d\u540c\u3002\u4f8b\u5982\uff0c\u7531\u4e8e\u89d2\u819c\u4e0d\u662f\u8840\u7ba1\u5316\u7684\uff0c\u4e14\u5f88\u5c11\u66b4\u9732\u5728\u63a5\u53d7\u8005\u7684\u514d\u75ab\u7cfb\u7edf\u4e2d\uff0c\u89d2\u819c\u79fb\u690d\u63a5\u53d7\u8005\u4e0d\u9700\u8981\u670d\u7528\u514d\u75ab\u6291\u5236\u836f\u7269\u3002\u809d\u79fb\u690d\u53ef\u4ee5\u5728HLA\u914d\u578b\u4e0d\u5408\u7684\u4f9b\u8005\u548c\u53d7\u8005\u4e4b\u95f4\u8fdb\u884c\uff0c\u5176\u539f\u56e0\u5c1a\u4e0d\u6e05\u695a\u3002\u5fc3\u810f\u79fb\u690d\u4e3b\u8981\u7528\u4e8e\u4e25\u91cd\u5fc3\u529b\u8870\u7aed\u3001\u4e0d\u63a5\u53d7\u79fb\u690d\u5c31\u4f1a\u6b7b\u4ea1\u7684\u60a3\u8005\uff0c\u800c\u8fdb\u884c\u5fc3\u810f\u79fb\u690d\u7684\u60a3\u8005\u5f80\u5f80\u6ca1\u6709\u5145\u5206\u7684\u65f6\u95f4\u7b49\u5f85HLA\u76f8\u5408\u7684\u6350\u8d60\u8005\uff0c\u56e0\u6b64\u60a3\u8005\u5728\u63a5\u53d7\u5fc3\u810f\u79fb\u690d\u65f6\uff0c\u901a\u5e38\u4f1a\u63a5\u53d7\u514d\u75ab\u6291\u5236\u836f\u7269\u7684\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 34.1<\/span> \u5404\u79cd\u5668\u5b98\u7684\u79fb\u690d\u8fc7\u7a0b<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6392\u65a5\u53cd\u5e94\u7684\u673a\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94<\/p>\n<\/section>\n

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\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\u4f1a\u5728\u79fb\u690d\u540e\u6570\u5c0f\u65f6\u5185\u53d1\u751f\uff0c\u662f\u7531\u4e8e\u79fb\u690d\u7269\u7684ABO\u8840\u578b\u6216HLA-I\u7c7b\u6297\u539f\u4e0e\u6297\u4f53\u7ed3\u5408\u800c\u5f15\u8d77\u7684(Fig. 34.1A<\/span>)\u3002\u63a5\u53d7\u8005\u5728\u6000\u5b55\u3001\u8f93\u8840\u6216\u4e4b\u524d\u7684\u79fb\u690d\u8fc7\u7a0b\u4e2d\u63a5\u89e6\u4e86\u540c\u79cd\u5f02\u4f53\u6dcb\u5df4\u7ec6\u80de\u540e\uff0c\u4f53\u5185\u53ef\u80fd\u5df2\u7ecf\u5f62\u6210\u4e86\u6297HLA-I\u7c7b\u6297\u4f53\u3002\u5f53\u6297\u4f53\u4e0e\u6297\u539f\u7ed3\u5408\u89e6\u53d1II\u578b\u8d85\u654f\u53cd\u5e94\u65f6\uff0c\u79fb\u690d\u7269\u4f1a\u56e0\u8840\u7ba1\u8840\u6813\u800c\u53d7\u5230\u7834\u574f\u3002\u901a\u8fc7\u4e25\u8c28\u7684ABO\u548cHLA\u4ea4\u53c9\u914d\u578b\u53ef\u4ee5\u9884\u9632\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\uff0c\u76ee\u524d\uff0c\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\u5df2\u76f8\u5f53\u5c11\u89c1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 34.1<\/span> \u80be\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u673a\u5236\u3002\u8d85\u6025\u6027(A)\u548c\u6025\u6027(B)\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u6d89\u53ca\u4e0d\u540c\u7684\u673a\u5236\u3002\u6162\u6027\u6392\u65a5\u53cd\u5e94(C)\u7684\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002CTL\uff1a\u7ec6\u80de\u6bd2T\u6dcb\u5df4\u7ec6\u80de\uff1bIL\uff1a\u767d\u7ec6\u80de\u4ecb\u7d20\uff1bTH\uff1a\u8f85\u52a9\u6027T\u7ec6\u80de\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6025\u6027\u6392\u65a5\u53cd\u5e94<\/p>\n<\/section>\n

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\u6025\u6027\u6392\u65a5\u53cd\u5e94<\/span>\u662f\u7531\u7ec6\u80de\u4ecb\u5bfc\u7684\u8fdf\u53d1\u578b<\/span>\uff08IV\u578b\uff09\u8d85\u654f\u53cd\u5e94\uff0c\u901a\u5e38\u53d1\u751f\u5728\u79fb\u690d\u540e<\/span>\u51e0\u5929\uff0c\u751a\u81f3\u51e0\u5468\u5185\uff0c\u8fd9\u662f\u56e0\u4e3a\u4f9b\u8005DC\u5fc5\u987b\u5148\u5728\u5c40\u90e8\u6dcb\u5df4\u7ed3\u5185\u5f15\u8d77\u540c\u79cd\u5f02\u4f53\u53cd\u5e94\uff0c\u4ee5\u4f7f\u53cd\u5e94\u7684T\u7ec6\u80de\u589e\u6b96\u5e76\u8fc1\u79fb\u5230\u4f9b\u8005\u80be\u810f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u679c\u4f9b\u8005\u4e0e\u53d7\u8005HLA\u914d\u578b\u4e0d\u5408\uff0c\u5219\u4f1a\u53d1\u751f\u6025\u6027\u6392\u65a5\u53cd\u5e94\u3002\u53d7\u4f53T\u7ec6\u80de\u80fd\u5bf9\u53d7\u4f53\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC) \u5448\u9012\u7684\u4f9b\u4f53\u591a\u80bd\u6216\u4f9b\u4f53MHC\u5206\u5b50\u4ea7\u751f\u53cd\u5e94(\u89c1Fig. 34.1<\/span>)\u3002\u867d\u7136\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u4f9b\u8005\u548c\u53d7\u8005\u7684HLA\u5339\u914d\u5ea6\uff0c\u6765\u964d\u4f4e\u6025\u6027\u6392\u65a5\u53cd\u5e94\u53d1\u751f\u7684\u53ef\u80fd\u6027\uff0c\u4f46\u7531\u4e8e\u4f9b\u4f53\u80be\u810f\u7684\u77ed\u7f3a\uff0c\u5bfc\u81f4\u79fb\u690d\u7684\u80be\u810f\u8fd8\u662f\u5b58\u5728\u90e8\u5206\u4e0d\u5339\u914d\u7684\u60c5\u51b5\u3002\u80be\u810f\u7684\u5b58\u6d3b\u4e5f\u4e0e\u5339\u914d\u7a0b\u5ea6\u6709\u5173\uff0c\u5c24\u5176\u662f\u5728HLA-DR\u4f4d\u70b9(Fig. 34.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u53d7\u4f53\u53ef\u80fd\u4f1a\u5bf9\u4f9b\u4f53\u6216\u53d7\u4f53\u7ec6\u80de\u5448\u9012\u7684\u6b21\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\uff08mHA\uff09\u4ea7\u751f\u6392\u65a5\u53cd\u5e94(\u89c1Box 34.1<\/span>)\u3002mHA\u662f\u5728\u4f9b\u4f53\u548c\u53d7\u4f53\u4e2d\u5177\u6709\u4e0d\u540c\u6c28\u57fa\u9178\u5e8f\u5217\u7684\u86cb\u767d\u8d28\uff0c\u5b83\u4eec\u662f\u7531\u4f4d\u4e8eHLA\u4e4b\u5916\u7684\u57fa\u56e0\u7f16\u7801\u7684\u3002\u7528\u6807\u51c6\u7684\u7ec4\u7ec7\u5206\u578b\u6280\u672f\u65e0\u6cd5\u68c0\u6d4b\u5230\u8f83\u8f7b\u5fae\u7684\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\u4e0d\u5339\u914d\u3002\u5c31\u91cd\u8981\u6027\u800c\u8a00\uff0c\u201c\u6b21\u8981\u6297\u539f\u201d\u8fd9\u4e00\u672f\u8bed\u53ef\u80fd\u5177\u6709\u8bef\u5bfc\u6027\uff0c\u5373\u4fbf\u662f\u627e\u5230\u4e86HLA\u76f8\u5408\u7684\u6d3b\u4f53\u4eb2\u5c5e\u4f9b\u8005\uff0c\u8fd9\u4e9b\u201c\u6b21\u8981\u6297\u539f\u201d\u4e5f\u53ef\u80fd\u5bfc\u81f4\u591a\u8fbe\u4e09\u5206\u4e4b\u4e00\u7684\u79fb\u690d\u7269\u51fa\u73b0\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u679c\u6350\u732e\u7684\u80be\u810f\u53d7\u635f\uff0c\u5f88\u53ef\u80fd\u53d1\u751f\u6025\u6027\u6392\u65a5\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u5982\u679c\u4e0d\u7acb\u5373\u5c06\u80be\u810f\u51b0\u51bb\uff0c\u5b83\u5c31\u4f1a\u56e0\u7f3a\u6c27\u800c\u53d7\u635f\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u7684\u635f\u4f24\u76f8\u5173\u5206\u5b50\u6a21\u5f0f(DAMPs)\u901a\u8fc7\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u68c0\u6d4b\uff0c\u523a\u6fc0\u673a\u4f53\u4ea7\u751f\u5371\u9669\u4fe1\u53f7(\u7b2c\u5341\u4e5d\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig. 34.2 <\/span>HLA\u4e0d\u76f8\u5408\u7684\u5668\u5b98\u79fb\u690d\u540e\u5b58\u6d3b\u7387\u8f83\u5dee\u3002\u800c\u4f7f\u7528\u4e86\u514d\u75ab\u6291\u5236\u5242\u540e\uff0c\u5373\u4f7f\u662f\u4e0d\u5339\u914d\u7684\u80be\u810f\uff0c\u4e5f\u53ef\u4ee5\u6709\u6548\u9884\u9632\u6392\u65a5\u53cd\u5e94\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6162\u6027\u6392\u65a5\u53cd\u5e94<\/p>\n<\/section>\n

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\u6162\u6027\u6392\u65a5\u53cd\u5e94\u53d1\u751f\u5728\u79fb\u690d\u540e\u7684\u6570\u6708\u6216\u6570\u5e74\u5185\u3002\u5728\u6162\u6027\u6392\u65a5\u53cd\u5e94\u4e2d\uff0c\u540c\u79cd\u5f02\u4f53\u53cd\u5e94\u901a\u5e38\u662f\u7531T\u7ec6\u80de\u4ecb\u5bfc\u7684\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u6162\u6027\u6392\u65a5\u53cd\u5e94\u53ef\u80fd\u662f\u7531\u5148\u524d\u5b58\u5728\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u590d\u53d1\u5f15\u8d77\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u8010\u53d7<\/p>\n<\/section>\n

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\u514d\u75ab\u8010\u53d7\u6307\u5bf9\u514d\u75ab\u7cfb\u7edf\u4e2d\u6709\u8bc6\u522b\u548c\u653b\u51fb\u80fd\u529b\u7684\u5206\u5b50\u5904\u4e8e\u65e0\u5e94\u7b54\u7684\u72b6\u6001(\u7b2c18\u7ae0<\/span>)\u3002\u5728\u79fb\u690d\u80cc\u666f\u4e0b\uff0c\u8fd9\u610f\u5473\u7740\u60a3\u8005\u4e0d\u4f1a\u5bf9\u79fb\u690d\u7ec4\u7ec7\u4e0a\u5b58\u5728\u7684\u540c\u79cd\u5f02\u4f53\u6297\u539f\u4ea7\u751f\u6392\u65a5\u53cd\u5e94\uff0c\u800c\u5bf9\u75c5\u539f\u4f53\u7684\u53cd\u5e94\u5219\u4e0d\u53d7\u5f71\u54cd\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c1a\u672a\u5b9e\u73b0\u5bf9\u79fb\u690d\u7684\u5b9e\u4f53\u5668\u5b98\u7684\u8010\u53d7\u6027\u3002 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u79fb\u690d\u65f6\u7ed9\u4e88\u514d\u75ab\u6291\u5236\u836f\u7269\u53ef\u4ee5\u9632\u6b62\u6392\u65a5\u53cd\u5e94\uff0c\u4f46\u4e00\u65e6\u505c\u6b62\u7528\u836f\uff0c\u4ecd\u4f1a\u53d1\u751f\u6392\u65a5\u53cd\u5e94\u3002\u514d\u75ab\u6291\u5236\u836f\u7269\u4e0d\u80fd\u7279\u5f02\u6027\u5730\u5f15\u53d1\u8010\u53d7\uff0c\u6240\u4ee5\u540c\u6837\u4f1a\u6291\u5236\u673a\u4f53\u5bf9\u611f\u67d3\u6027\u75c5\u539f\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4f7f\u7528\u5f3a\u6548\u514d\u75ab\u6291\u5236\u836f\u7269\u7684\u4e3b\u8981\u9650\u5236\u56e0\u7d20\u662f\u673a\u4f1a\u6027\u611f\u67d3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u5e72\u7ec6\u80de\u79fb\u690d(SCT)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e00\u4e9b\u4e34\u5e8a\u6848\u4f8b\u4e2d\uff0c\u9020\u8840\u5e72\u7ec6\u80de\u53ef\u518d\u751f\u9aa8\u9ad3\u548c\u6dcb\u5df4\u7ec6\u80de<\/span>\u3002\u5728\u81ea\u4f53SCT\u4e2d\uff0c\u7ecf\u8fc7\u5f3a\u6548\u5316\u7597\u540e\uff0c\u53d6\u51fa\u9aa8\u9ad3\u3001\u51b7\u51bb\u5e76\u91cd\u65b0\u8f93\u6ce8\u56de\u4f53\u5185\u3002\u81ea\u4f53\u79fb\u690d\u7684\u514d\u75ab\u98ce\u9669\u662f\u6700\u5c0f\u7684\uff0c\u540c\u79cd\u5f02\u4f53SCT\u6bd4\u5927\u591a\u6570\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u7684\u98ce\u9669\u6027\u66f4\u9ad8\u3002\u5373\u4f7f\u5728\u7406\u60f3\u7684\u60c5\u51b5\u4e0b\uff0c\u63a5\u53d7\u8005\u4e0e\u6350\u8d60\u8005\u5339\u914d\u826f\u597d\uff0c\u6b7b\u4ea1\u7387\u4e5f\u53ef\u80fd\u9ad8\u8fbe20%(\u89c1Box 34.2<\/span>)\uff0c\u8fd9\u79cd\u98ce\u9669\u57fa\u672c\u662f\u7531GVHD\u9020\u6210\u7684\u3002\u7531\u4e8e\u79fb\u690d\u98ce\u9669\u5f88\u9ad8\uff0c\u540c\u79cd\u5f02\u4f53SCT\u4ec5\u5728\u6ca1\u6709\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\u7684\u7d27\u6025\u60c5\u51b5\u4e0b\u91c7\u7528\uff0c\u4f8b\u5982:<\/p>\n

\u2022\u5728\u6076\u6027\u8840\u6db2\u75c5\u4e2d(\u5982\u679c\u590d\u53d1\u53ef\u80fd\u6027\u5f88\u9ad8\uff0c\u5219\u5728\u521d\u6b65\u6cbb\u7597\u540e\u8fdb\u884cSCT\uff0c\u524d\u63d0\u662f\u5df2\u7ecf\u7ecf\u8fc7\u4e86\u5f3a\u6548\u7684\u5316\u7597\u548c\u653e\u7597\u3002)<\/p>\n

\u2022\u5f53\u9ad3\u7cfb\u7ec6\u80de\u751f\u6210\u51cf\u5c11\u6216\u660e\u663e\u5f02\u5e38\u65f6\uff0c\u5982\u518d\u751f\u969c\u788d\u6027\u8d2b\u8840\u3002<\/p>\n

\u2022\u539f\u53d1\u6027\u514d\u75ab\u7f3a\u9677\uff0c\u5982\u4e25\u91cd\u8054\u5408\u514d\u75ab\u7f3a\u9677(SCID)<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5e72\u7ec6\u80de\u7684\u6765\u6e90<\/p>\n<\/section>\n

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\u5e72\u7ec6\u80de\u79fb\u690d\u6210\u529f\u540e\uff0c\u9020\u8840\u5e72\u7ec6\u80de\u53ef\u518d\u751f\u9ad3\u7cfb\u7ec6\u80de\u3002\u5e72\u7ec6\u80de\u6709\u591a\u79cd\u6765\u6e90\uff1a<\/span><\/p>\n

\u2022\u901a\u5e38\u5e72\u7ec6\u80de\u6765\u6e90\u4e8e\u9aa8\u9ad3\u3002\u91c7\u96c6\u5e72\u7ec6\u80de\u9700\u8981\u5728\u5168\u8eab\u9ebb\u9189\u4e0b\u62bd\u53d6\u4e00\u5b9a\u6570\u91cf\u7684\u4f9b\u4f53\u9aa8\u9ad3\u3002<\/p>\n

\u2022\u5bf9\u4f9b\u4f53\u4f7f\u7528\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u540e\u53ef\u83b7\u5f97\u5916\u5468\u8840\u5e72\u7ec6\u80de\uff0c\u4ee5\u589e\u52a0\u5faa\u73af\u5e72\u7ec6\u80de\u7684\u6570\u91cf\u3002<\/p>\n

\u2022\u8110\u5e26\u8840\u542b\u6709\u5927\u91cf\u5e72\u7ec6\u80de\uff0c\u4f7f\u7528\u524d\u53ef\u4ee5\u51b7\u51bb\u3002\u8110\u5e26\u8840\u7684\u4e00\u4e2a\u4f18\u70b9\u662f\u672a\u6210\u719f\u7684\u6dcb\u5df4\u7ec6\u80de\u4e0d\u592a\u53ef\u80fd\u5f15\u8d77GVHD(\u7a0d\u540e\u4f1a\u8be6\u7ec6\u8ba8\u8bba)\u3002\u8110\u5e26\u8840\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u5e72\u7ec6\u80de\uff0c\u4f46\u53ea\u80fd\u79fb\u690d\u5230\u513f\u7ae5\u4f53\u5185\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9884\u5904\u7406<\/p>\n<\/section>\n

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\u9884\u5904\u7406\u5305\u62ec\u5927\u5242\u91cf\u5316\u7597\u6216\u653e\u7597<\/span>\uff0c\u8fd9\u4f1a\u7834\u574f\u53d7\u4f53\u81ea\u8eab\u7684\u5e72\u7ec6\u80de\uff0c\u5e76\u5141\u8bb8\u4f9b\u4f53\u5e72\u7ec6\u80de\u690d\u5165\u3002\u9664\u4e86\u5728\u9aa8\u9ad3\u4e2d\u4e3a\u4f9b\u8005\u9aa8\u9ad3\u7ec6\u80de\u690d\u5165\u63d0\u4f9b\u7a7a\u95f4\u5916\uff0c\u5b83\u8fd8\u964d\u4f4e\u4e86\u53d7\u4f53\u514d\u75ab\u7cfb\u7edf\u6392\u65a5\u540c\u79cd\u5f02\u4f53(\u4f9b\u4f53)\u5e72\u7ec6\u80de\u7684\u98ce\u9669\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09<\/p>\n<\/section>\n

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    \u5f53\u4f9b\u8005T\u7ec6\u80de\u5bf9\u540c\u79cd\u5f02\u4f53\u53d7\u4f53\u6297\u539f\u6709\u53cd\u5e94\u65f6\uff08\u5982\u4e3b\u8981\u6216\u6b21\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\u5b58\u5728\u4e0d\u5339\u914d\uff09\uff0c\u5c31\u4f1a\u53d1\u751fGVHD\u3002\u6240\u6709\u63a5\u53d7SCT\u7684\u60a3\u8005\u90fd\u4f1a\u88ab\u7ed9\u4e88\u514d\u75ab\u6291\u5236\u836f\u7269\u6765\u9884\u9632GVHD\uff0c\u5373\u4f7f\u4f9b\u8005\u548c\u63a5\u53d7\u8005\u7684\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u5b8c\u5168\u76f8\u540c\u3002GVHD\u901a\u5e38\u53d1\u751f\u5728SCT\u540e\u76844\u5468\u5185\uff0c\u53d1\u4f5c\u65f6\u76ae\u80a4\u3001\u80a0\u9053\u3001\u809d\u810f\u548c\u80ba\u90e8\u5e7f\u6cdb\u53d7\u7d2f\uff1b\u4e25\u91cd\u65f6\uff0cGVHD\u7684\u6b7b\u4ea1\u7387\u8fbe70%\u3002\u6162\u6027GVHD\u53d1\u751f\u8f83\u665a\uff0c\u4f1a\u5f71\u54cd\u76ae\u80a4\u548c\u809d\u810f\u3002<\/p>\n

    \u4ece\u5e72\u7ec6\u80de\u6765\u6e90\u4e2d\u79fb\u9664\u6210\u719f\u7684T\u7ec6\u80de\u53ef\u4ee5\u964d\u4f4eGVHD\u7684\u98ce\u9669\u3002\u7136\u800c\uff0cT\u7ec6\u80de\u8017\u5c3d\u4f1a\u589e\u52a0\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u7684\u98ce\u9669\uff0c\u4f9b\u4f53T\u7ec6\u80de\u4e5f\u80fd\u591f\u5bf9\u6297\u53d7\u4f53\u80bf\u7624\u7ec6\u80de\uff0c\u7279\u522b\u662f\u5b58\u5728\u4e00\u5b9a\u7a0b\u5ea6\u7684HLA\u4e0d\u5339\u914d\u73b0\u8c61\u4ee5\u53ca\u8f7b\u5ea6GVHD\u53d1\u751f\u65f6\u3002\u5728\u5e72\u7ec6\u80de\u6765\u6e90\u7684T\u7ec6\u80de\u8017\u5c3d\u540e\uff0c\u8fd9\u79cd\u6709\u76ca\u7684\u6297\u767d\u8840\u75c5\u4f5c\u7528\u5c31\u6d88\u5931\u4e86(Fig. 34.3<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig. 34.3<\/span> T\u7ec6\u80de\u8017\u7aed\u5bf9\u5e72\u7ec6\u80de\u79fb\u690d\u6709\u590d\u6742\u7684\u5f71\u54cd<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u7ec4\u7ec7\u5206\u578b\u6280\u672f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u5927\u591a\u6570\u540c\u79cd\u5f02\u4f53\u79fb\u690d\u4e4b\u524d\uff0c\u6700\u597d\u786e\u4fdd\u4f9b\u4f53\u548c\u53d7\u4f53\u5177\u6709\u5c3d\u53ef\u80fd\u76f8\u8fd1\u7684HLA\u7b49\u4f4d\u57fa\u56e0\u3002\u540c\u6837\u91cd\u8981\u7684\u662f\uff0c\u8981\u786e\u4fdd\u4f9b\u8005\u6ca1\u6709\u9488\u5bf9\u53d7\u4f53\u7ec6\u80de\u7684\u6297\u4f53\uff0c\u8fd9\u4e9b\u6297\u4f53\u662f\u901a\u8fc7\u4ea4\u53c9\u914d\u578b\u8fdb\u884c\u68c0\u6d4b\u7684\u3002\u603b\u7684\u6765\u8bf4\uff0c\u5728\u540c\u79cd\u5f02\u4f53\u79fb\u690d\u524d\u8fdb\u884c\u7684\u8fd9\u4e9b\u6d4b\u8bd5\u88ab\u79f0\u4e3a\u7ec4\u7ec7\u5206\u578b\uff0c\u7528\u4e8e\u8bc6\u522b\u5e76\u53d1\u75c7\u98ce\u9669\u6700\u4f4e\u7684\u4f9b\u4f53-\u53d7\u4f53\u5bf9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u5206\u578b<\/p>\n<\/section>\n

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\u5bf9\u6b63\u5728\u8003\u8651\u63a5\u53d7\u79fb\u690d\u7684\u60a3\u8005\u8fdb\u884c\u7ec4\u7ec7\u5206\u578b\uff0c\u80fd\u591f\u786e\u5b9aHLA\u7b49\u4f4d\u57fa\u56e0\u3002\u5728\u51e0\u767e\u4e07\u5e74\u7684\u65f6\u95f4\u91cc\uff0c\u4eba\u7c7b\u8fdb\u5316\u51fa\u4e86500\u591a\u79cd\u4e0d\u540c\u7684HLA\u7b49\u4f4d\u57fa\u56e0\uff0c\u9700\u8981\u5206\u5b50\u751f\u7269\u5b66\u6280\u672f\u6765\u7cbe\u786e\u5b9a\u4e49\u6bcf\u4e2a\u4e2a\u4f53\u7684HLA\u7c7b\u578b(Fig. 34.4A<\/span>)\u3002\u5982\u679c\u60a3\u8005\u6709\u5408\u9002\u7684\u5144\u5f1f\u59d0\u59b9\uff0c\u53ef\u4ee5\u5728\u5bb6\u5ead\u5185\u5bfb\u627e\u5728\u4e16\u7684\u4eb2\u5c5e\u6350\u8d60\u8005\u3002\u7136\u800c\uff0c\u4efb\u4f55\u4e00\u4e2a\u5144\u5f1f\u59d0\u59b9\u90fd\u53ea\u6709\u56db\u5206\u4e4b\u4e00\u7684\u673a\u4f1a\u662fHLA\u5b8c\u5168\u5339\u914d\u7684\u3002\u5982\u679c\u627e\u5230\u4e86\u5408\u9002\u7684\u4eb2\u5c5e\uff0c\u90a3\u4e48\u4ed6\u6216\u5979\u53ef\u4ee5\u5145\u5f53\u6350\u8d60\u8005\u3002\u5426\u5219\uff0c\u9700\u8981\u5b9e\u4f53\u5668\u5b98\u79fb\u690d(\u5982\u80be\u810f)\u7684\u60a3\u8005\u9700\u8981\u5728\u7b49\u5f85\u540d\u5355\u767b\u8bb0\u5904\u767b\u8bb0(\u89c1Fig. 34.4B<\/span>)\uff0c\u5f53\u6709\u5408\u9002\u7684\u5668\u5b98\u53ef\u7528\u65f6\uff0c\u4f9b\u4f53\u8fdb\u884c HLA \u5206\u578b\uff0c\u5e76\u5728\u7ec4\u7ec7\u5206\u578b\u767b\u8bb0\u5904\u641c\u7d22\u5408\u9002\u7684\u53d7\u4f53\uff08\u89c1Fig. 34.4C<\/span>\uff09\u3002\u5373\u4f7f\u73b0\u5728\u5668\u5b98\u767b\u8bb0\u6269\u5c55\u5230\u8bb8\u591a\u5dde\u6216\u56fd\u5bb6\uff0c\u4e5f\u6709\u53ef\u80fd\u9700\u8981\u7b49\u5f85\u6570\u6708\u624d\u80fd\u83b7\u5f97\u5339\u914d\u826f\u597d\u7684\u5668\u5b98\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u767b\u8bb0\u5904\u4e5f\u7528\u4e8e\u9700\u8981SCT\u7684\u60a3\u8005\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u767b\u8bb0\u5904\u7531\u540c\u610f\u6210\u4e3a\u6f5c\u5728\u6350\u8d60\u8005\u5e76\u5df2\u8fdb\u884cHLA\u5206\u578b\u7684\u5fd7\u613f\u8005\u7ec4\u6210\u3002\u7136\u800c\uff0c\u5373\u4f7f\u767b\u8bb0\u5904\u5305\u62ec\u6570\u767e\u4e07\u6350\u8d60\u8005\uff0c\u63a5\u53d7\u8005\u4e5f\u6709\u53ef\u80fd\u627e\u4e0d\u5230HLA\u76f8\u5408\u7684\u6350\u8d60\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 34.4<\/span> \u9700\u8981\u80be\u79fb\u690d\u7684\u60a3\u8005\u7684HLA\u578b(A)\uff0c\u7136\u540e\u767b\u8bb0\u5728\u767b\u8bb0\u5904(B)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 34.4,\u7eed <\/span>\u6350\u8d60\u8005\u662f\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f(C)\u578b\u3002D.\u6765\u81ea\u6350\u732e\u8005\u8840\u6db2\u7684B\u7ec6\u80de(\u56e0\u4e3a\u5b83\u4eec\u8868\u8fbeHLA I\u7c7b\u548cII\u7c7b)\u4e0e\u53d7\u4f53\u8840\u6e05\u6df7\u5408\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u4ea4\u53c9\u914d\u578b<\/p>\n<\/section>\n

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\u4ea4\u53c9\u914d\u578b\u662f\u4e3a\u4e86\u6392\u9664\u9488\u5bf9\u4f9b\u4f53HLA\u800c\u5bfc\u81f4\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\u7684\u6297\u4f53(\u89c1Fig. 34.4D<\/span>)\u3002\u5982\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u6297\u4f53\u53ef\u80fd\u662f\u5728\u6000\u5b55\u3001\u8f93\u8840\u6216\u4e4b\u524d\u7684\u79fb\u690d\u624b\u672f\u4e2d\u66b4\u9732\u4e8e\u540c\u79cd\u5f02\u4f53HLA\u800c\u4ea7\u751f\u7684\u3002\u5728\u4ea4\u53c9\u914d\u578b\u4e2d\uff0c\u4f9b\u4f53B\u7ec6\u80de\u4e0e\u53d7\u4f53\u8840\u6e05\u5171\u540c\u5b75\u80b2\u3002\u9009\u62e9\u4f9b\u8005B\u7ec6\u80de\u7528\u4e8e\u4ea4\u53c9\u914d\u578b\uff0c\u662f\u56e0\u4e3a\u5b83\u4eec\u8868\u8fbeHLA I\u548cII\u7c7b\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u6291\u5236\u836f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9700\u8981\u514d\u75ab\u6291\u5236\u836f\u7269\u6765\u9884\u9632\u548c\u6cbb\u7597\u79fb\u690d\u7269\u6392\u65a5\u53cd\u5e94\u548cGVHD\u3002\u8fd9\u4e9b\u836f\u7269\u5f80\u5f80\u4f1a\u5728\u5408\u7406\u7684\u6cbb\u7597\u65b9\u6848\u4e2d\u8054\u5408\u4f7f\u7528\u3002\u4f8b\u5982\uff0c\u5728\u80be\u79fb\u690d\u4e2d\uff0c\u53ef\u4ee5\u4ece\u79fb\u690d\u65f6\u5f00\u59cb\u4f7f\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\u3001\u73af\u5b62\u7d20\u548c\u9709\u915a\u9178\u916f\u7b49\u8054\u5408\u7597\u6cd5\u3002\u5e94\u6839\u636e\u6392\u65a5\u53cd\u5e94\u7684\u98ce\u9669\u7684\u9ad8\u4f4e\u800c\u51b3\u5b9a\u4f7f\u7528\u4e0d\u540c\u836f\u7269\u548c\u4f7f\u7528\u65f6\u95f4\u3002\u5982\u679c\u5df2\u77e5HLA\u914d\u578b\u4e0d\u5b8c\u5168\uff0c\u53ef\u80fd\u9700\u8981\u4f7f\u7528\u66f4\u957f\u65f6\u95f4\u66f4\u6709\u6548\u836f\u7269\u7684\u7ec4\u5408\u3002\u5982\u679c\u53d1\u751f\u6392\u65a5\u53cd\u5e94\uff0c\u53ef\u80fd\u9700\u8981\u7ed9\u51fa\u66f4\u5f3a\u7684\u836f\u7269\u3002\u7531\u4e8e\u514d\u75ab\u6291\u5236\uff0c\u4f7f\u7528\u8fd9\u4e9b\u836f\u7269\u90fd\u6709\u589e\u52a0\u673a\u4f53\u611f\u67d3\u7684\u98ce\u9669\u3002\u6b64\u5916\uff0c\u5982\u7b2c35\u7ae0<\/span>\u6240\u8ff0\uff0c\u514d\u75ab\u6291\u5236\u836f\u7269\u4f1a\u589e\u52a0\u60a3\u6709\u67d0\u4e9b\u80bf\u7624\u7684\u98ce\u9669\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e9b\u836f\u7269\u4e2d\u6709\u8bb8\u591a\u4e5f\u7528\u4e8e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u719f\u6089\u5b83\u4eec\u7684\u4f5c\u7528\u673a\u5236\u662f\u5f88\u91cd\u8981\u7684(Fig. 34.5<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 34.5 <\/span>\u4e3b\u8981\u514d\u75ab\u6291\u5236\u5242(\u76ae\u8d28\u7c7b\u56fa\u9187\u9664\u5916)\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ae\u8d28\u7c7b\u56fa\u9187<\/p>\n<\/section>\n

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\u76ae\u8d28\u7c7b\u56fa\u9187\u53ef\u6291\u5236100\u591a\u79cd\u86cb\u767d\u8d28\u7684\u5408\u6210\uff0c\u4f46\u5728\u4f4e\u5242\u91cf\u65f6\uff0c\u5b83\u4eec\u4e3b\u8981\u4f5c\u7528\u4e8e\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff0c\u9632\u6b62\u5728\u67d0\u4e9b\u65e9\u671f\u9636\u6bb5\u53d1\u751f\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u3002\u8f83\u9ad8\u5242\u91cf\u7684\u76ae\u8d28\u7c7b\u56fa\u9187\u5bf9T\u7ec6\u80de\u6709\u76f4\u63a5\u4f5c\u7528\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u6392\u65a5\u53cd\u5e94(\u7b2c31\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u963b\u65ad<\/p>\n<\/section>\n

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\u73af\u5b62\u7d20\u548c\u4ed6\u514b\u83ab\u53f8\u5728Box 11.3<\/span>\u4e2d\u8fdb\u884c\u8fc7\u4ecb\u7ecd\u3002\u5b83\u4eec\u901a\u8fc7\u4e0e\u7ec6\u80de\u5185T\u7ec6\u80de\u4fe1\u53f7\u7ea7\u8054\u4e2d\u7684\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u6765\u53d1\u6325\u4f5c\u7528\u3002\u7b2c\u4e00\u4e2a\u88ab\u53d1\u73b0\u7684\u6b64\u7c7b\u836f\u7269\u662f\u73af\u5b62\u7d20\uff0c\u73af\u5b62\u7d20\u80fd\u6781\u5927\u6539\u5584\u4e0d\u540c\u7c7b\u578b\u7684\u79fb\u690d\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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IL-2\u963b\u65ad<\/p>\n<\/section>\n

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\u6297IL-2\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53(\u5982\u5df4\u5229\u6614\u5355\u6297\u548c\u8fbe\u5229\u73e0\u5355\u6297), \u5b8c\u5168\u963b\u65ad\u4e86\u6240\u6709\u6dcb\u5df4\u7ec6\u80de\u6700\u91cd\u8981\u7684\u751f\u957f\u56e0\u5b50\uff0c\u5e76\u5177\u6709\u5f3a\u5927\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002\u5b83\u4eec\u975e\u5e38\u6709\u6548\uff0c\u53ea\u88ab\u7528\u6765\u6cbb\u7597\u6025\u6027\u79fb\u690d\u7269\u6392\u65a5\u53cd\u5e94\u3002\u96f7\u5e15\u9709\u7d20\u662f\u4e00\u79cd\u53e3\u670d\u836f\u7269\uff0c\u53ef\u4ee5\u4e0eIL-2\u53d7\u4f53\u4e0b\u6e38\u7684\u4fe1\u53f7\u76f8\u4e92\u4f5c\u7528\u3002\u4e0e\u5355\u514b\u9686\u6297\u4f53\u76f8\u6bd4\uff0c\u96f7\u5e15\u9709\u7d20\u7684\u6548\u529b\u66f4\u5f31\uff0c\u66f4\u5bb9\u6613\u670d\u7528\uff0c\u56e0\u6b64\u88ab\u7528\u6765\u9884\u9632\u79fb\u690d\u7269\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6297\u6076\u6027\u7ec6\u80de\u589e\u751f<\/p>\n<\/section>\n

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\u6297\u589e\u6b96\u836f\u7269\u786b\u5511\u560c\u5464\u3001\u9709\u915a\u9178\u916f\u548c\u7532\u6c28\u8776\u5464\u53ef\u6291\u5236DNA\u7684\u4ea7\u751f\u3002\u8fd9\u4e9b\u836f\u7269\u53ef\u4ee5\u9632\u6b62\u6dcb\u5df4\u7ec6\u80de\u589e\u6b96\uff08\u4e0d\u9488\u5bf9T\u7ec6\u80de\uff09\uff0c\u53ef\u80fd\u4f1a\u5f15\u8d77\u9aa8\u9ad3\u6bd2\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5f02\u79cd\u5668\u5b98\u79fb\u690d<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u6291\u5236\u836f\u7269\u663e\u8457\u6539\u5584\u4e86\u79fb\u690d\u7684\u6548\u679c\u3002\u7136\u800c\uff0c\u5b9e\u4f53\u5668\u5b98\u79fb\u690d\u7684\u7b49\u5f85\u540d\u5355\u6bcf10\u5e74\u7ffb\u4e00\u756a\uff0c\u800c\u79fb\u690d\u7684\u6570\u91cf\u5374\u4fdd\u6301\u4e0d\u53d8\u3002\u8fd9\u662f\u56e0\u4e3a\u53ef\u4f9b\u4f7f\u7528\u7684\u4eba\u4f53\u5668\u5b98\u592a\u5c11\uff0c\u65e0\u6cd5\u6ee1\u8db3\u60a3\u8005\u7684\u9700\u8981\u3002\u76ee\u524d\uff0c\u7f8e\u56fd\u6bcf\u5929\u670910\u540d\u60a3\u8005\u5728\u7b49\u5f85\u63a5\u53d7\u6551\u547d\u7684\u91cd\u8981\u5668\u5b98\u79fb\u690d\u7684\u8fc7\u7a0b\u4e2d\u6b7b\u4ea1\u3002\u56e0\u6b64\uff0c\u6765\u81ea\u5176\u4ed6\u7269\u79cd\u7684\u5f02\u79cd\u79fb\u690d\u5c06\u6765\u53ef\u80fd\u6210\u4e3a\u4e00\u79cd\u9009\u62e9\u3002\u4f46\u5728\u63d0\u4f9b\u53ef\u9760\u7684\u5668\u5b98\u6765\u6e90\u4e4b\u524d\uff0c\u9700\u8981\u514b\u670d\u51e0\u4e2a\u95ee\u9898\uff1a<\/p>\n

\u2022\u7075\u957f\u7c7b\u52a8\u7269\u7cd6\u4fa7\u94fe\u7684\u7ec4\u88c5\u548c\u5176\u4ed6\u7269\u79cd\u7684\u4e0d\u540c\u3002\u534a\u4e73\u7cd6-\u03b11,3-\u534a\u4e73\u7cd6 (gal-\u03b11,3-gal) \u662f\u4e00\u79cd\u5b58\u5728\u4e8e\u5927\u591a\u6570\u975e\u7075\u957f\u7c7b\u52a8\u7269\u7ec6\u80de\u4e2d\u7684\u7cd6\u3002\u514d\u75ab\u7cfb\u7edf\u53ef\u4ee5\u8bc6\u522b gal-\u03b11,3-gal\uff0c\u4f8b\u5982\uff0c\u6240\u6709\u4eba\u7c7b\u5728\u63a5\u89e6\u80a0\u9053\u7ec6\u83cc\u540e\u90fd\u4f1a\u4ea7\u751f\u9488\u5bf9\u5b83\u7684\u6297\u4f53\u3002\u7c7b\u4f3c\u7684\u5929\u7136\u6297\u4f53\u5728\u7b2c28\u7ae0<\/span>\u4e2d\u4e5f\u63d0\u5230\u8fc7\u3002\u6297Gal-\u03b11\uff0c3-Gal\u6297\u4f53\u4e0e\u5f02\u79cd\u79fb\u690d\u5668\u5b98\u7ed3\u5408\uff0c\u6fc0\u6d3b\u8865\u4f53\uff0c\u5f15\u53d1\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n

\u2022\u5176\u4ed6\u7269\u79cd\u7684\u8865\u4f53\u6291\u5236\u5242\u4e0d\u4f1a\u6291\u5236\u4eba\u7c7b\u8865\u4f53\u3002\u7531\u4e8e\u8fd9\u79cd\u5206\u5b50\u4e0d\u76f8\u5bb9\u6027\uff0c\u5f02\u79cd\u79fb\u690d\u5668\u5b98\u4f1a\u6fc0\u6d3b\u8865\u4f53(\u7b2c20\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b63\u5728\u7814\u53d1\u4e2d\u7684\u8f6c\u57fa\u56e0\u732a\u7684Gal-\u03b11\uff0c3-Gal\u8868\u8fbe\u964d\u4f4e\uff0c\u53ef\u4ee5\u9632\u6b62\u5929\u7136\u6297\u4f53\u7ed3\u5408\uff0c\u5e76\u4e0e\u4eba\u8865\u4f53\u6291\u5236\u5242\u4e00\u8d77\u4f7f\u7528\u6765\u907f\u514d\u5206\u5b50\u4e0d\u76f8\u5bb9\u3002\u4e4b\u6240\u4ee5\u4f7f\u7528\u732a\uff0c\u662f\u56e0\u4e3a\u5b83\u4eec\u7684\u5668\u5b98\u5927\u5c0f\u4e0e\u4eba\u7c7b\u76f8\u4f3c\uff0c\u5e76\u4e14\u5bb9\u6613\u5708\u517b\u3002\u7136\u800c\uff0c\u4ecd\u7136\u8fd8\u5b58\u5728\u4e24\u4e2a\u76f8\u5f53\u5927\u7684\u7406\u8bba\u95ee\u9898\uff1a<\/p>\n

1.\u732a\u86cb\u767d\u5f15\u8d77\u7684T\u7ec6\u80de\u53cd\u5e94\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6025\u6027\u6392\u65a5\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/p>\n

2.\u5373\u4f7f\u662f\u5728\u65e0\u5fae\u751f\u7269\u6761\u4ef6\u4e0b\u9972\u517b\u7684\u732a\u4e5f\u4f1a\u611f\u67d3\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff0c\u5b83\u4eec\u53ef\u4ee5\u5728\u79fb\u690d\u540e\u611f\u67d3\u4eba\u7c7b\u3002\u732a\u75c5\u6bd2\u66f4\u5bb9\u6613\u611f\u67d3\u670d\u7528\u514d\u75ab\u6291\u5236\u5242\u7684\u63a5\u53d7\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX\u200334.1 <\/span>\u6025\u6027\u79fb\u690d\u6392\u65a5\u53cd\u5e94<\/span>
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\u5973\u6027\uff0c43\u5c81\uff0c\u60a3\u6709\u591a\u56ca\u80be\u75c5\uff08\u4e00\u79cd\u9000\u884c\u6027\u75be\u75c5\uff0c\u901a\u5e38\u4f1a\u5bfc\u81f4\u4e0d\u53ef\u9006\u8f6c\u7684\u80be\u8870\u7aed\uff09\u3002\u4e09\u5e74\u524d\uff0c\u80be\u8870\u7aed\u52a0\u91cd\uff0c\u60a3\u8005\u6bcf\u5468\u4e09\u6b21\u8840\u6db2\u900f\u6790\uff0c\u8f6c\u8bca\u5230\u80be\u79fb\u690d\u7ec4\uff0c\u4f5c\u4e3a\u79fb\u690d\u5019\u9009\u8005\u8fdb\u884cHLA\u5206\u578b\uff0c\u867d\u7136\u5979\u7684 HLA \u7b49\u4f4d\u57fa\u56e0\u8f83\u5e38\u89c1\uff0c\u4f46\u4ecd\u53ef\u80fd\u8981\u7b49\u5f88\u957f\u65f6\u95f4\u624d\u80fd\u83b7\u5f97\u53ef\u79fb\u690d\u80be\u810f\u3002\u8fd9\u662f\u56e0\u4e3a\u5927\u591a\u6570\u80be\u810f\u79fb\u690d\u8ba1\u5212\u7684\u76ee\u6807\u662f\u5c3d\u53ef\u80fd\u5730\u5339\u914d\u6350\u8d60\u8005\u548c\u63a5\u53d7\u8005\uff0c\u800c\u57285000\u540d\u65e0\u5173\u7684\u4e2a\u4eba\u4e2d\uff0c\u53ea\u6709\u5927\u7ea61\u4eba\u62e5\u6709\u76f8\u540c\u7684HLA\u7c7b\u578b\u3002<\/p>\n

\u4eb2\u5c5e\u6350\u8d60\u8005\u5728\u80be\u79fb\u690d\u4e2d\u5f88\u91cd\u8981\uff0c\u524d\u63d0\u662f\u4ed6\u4eec\u6ca1\u6709\u53d7\u5230\u540c\u6837\u7684\u9057\u4f20\u75c5\u7684\u5f71\u54cd\u3002\u8be5\u60a3\u8005\u6709\u4e09\u4e2a\u5144\u5f1f\uff0c\u4ed6\u4eec\u90fd\u6ca1\u6709\u53d7\u5230\u591a\u56ca\u80be\u75c5\u7684\u5f71\u54cd\u3002\u7531\u4e8e\u9700\u8981\u6f2b\u957f\u7684\u7b49\u5f85\uff0c\u60a3\u8005\u7684\u5144\u5f1f\u4eec\u51b3\u5b9a\u63a5\u53d7\u7ec4\u7ec7\u5206\u578b\uff0c\u5176\u4e2d\u4e00\u4eba\u7ecf\u68c0\u6d4b\u4e0e\u60a3\u8005\u7684HLA\u548c\u8840\u578b\u5b8c\u5168\u5339\u914d\u3002\u5728\u4ea4\u53c9\u5339\u914d\u8fc7\u7a0b\u4e2d\uff0c\u75c5\u4eba\u7684\u8840\u6e05\u4e0e\u5979\u54e5\u54e5\u7684\u6dcb\u5df4\u7ec6\u80de\u6ca1\u6709\u53cd\u5e94\uff0c\u79fb\u690d\u540e\u672a\u53d1\u73b0\u8d85\u6025\u6027\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n

\u5728\u76ee\u524d\u7684\u6280\u672f\u4e0b\uff0c\u5339\u914d\u6b21\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\u662f\u4e0d\u53ef\u80fd\u7684\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5f15\u53d1\u79fb\u690d\u6392\u65a5\u53cd\u5e94\uff0c\u5373\u4f7f\u662f\u5728\u6d3b\u4f53\u4eb2\u5c5e\u6350\u8d60\u8005\u7684HLA\u5339\u914d\u7684\u5668\u5b98\u4e2d\u4e5f\u662f\u5982\u6b64\u3002\u4e3a\u6b64\uff0c\u8be5\u60a3\u8005\u63a5\u53d7\u4e86\u73af\u5b62\u7d20\u3001\u9709\u915a\u9178\u916f\u548c\u76ae\u8d28\u7c7b\u56fa\u9187\u9884\u9632\u79fb\u690d\u540e\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n

\u79fb\u690d\u4f3c\u4e4e\u8fdb\u5c55\u987a\u5229\uff0c\u4f46\u5728\u7b2c8\u5929\u65f6\u75c5\u4eba\u5f00\u59cb\u611f\u5230\u4e0d\u9002\u548c\u53d1\u70e7\u3002\u5728\u89e6\u8bca\u4e2d\u79fb\u690d\u7684\u80be\u810f\u80bf\u80c0\uff0c\u8840\u6db2\u68c0\u67e5\u663e\u793a\u5979\u7684\u80be\u529f\u80fd\u6076\u5316\u3002<\/p>\n

\u80be\u6d3b\u68c0\u663e\u793a\u4e3a\u8f7b\u5fae\u6297\u539f\u4e0d\u5339\u914d\u5f15\u8d77\u7684\u6025\u6027\u6392\u65a5\u53cd\u5e94(Fig. 34.6<\/span>)\u3002\u4f7f\u7528\u4e86\u5927\u5242\u91cf\u76ae\u8d28\u7c7b\u56fa\u9187\u6cbb\u7597\u65e0\u6548\uff0c\u968f\u540e\u63a5\u53d7\u4e865\u5929\u7684IL-2\u53d7\u4f53\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\uff0c\u5728\u6b64\u671f\u95f4\u80be\u529f\u80fd\u5f97\u5230\u6539\u5584\uff0c\u6ca1\u6709\u8fdb\u4e00\u6b65\u7684\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n

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Fig. 34.6 <\/span>\u80be\u79fb\u690d\u6d3b\u68c0\u663e\u793a\u79fb\u690d\u7269\u5185\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\uff0c\u7b26\u5408\u6025\u6027\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 34.2 <\/span>\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u7684\u611f\u67d3<\/span><\/p>\n<\/section>\n<\/section>\n

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36\u5c81\uff0c\u6dcb\u5df4\u7624\u5973\u6027\u60a3\u8005\uff0c\u5316\u7597\u5b58\u5728\u590d\u53d1\u98ce\u9669\u7387\u5f88\u9ad8\u3002\u5144\u5f1f\u59d0\u59b9\u548c\u5979\u90fd\u4e0d\u662f\u540c\u4e00\u79cdHLA\u3002\u5728\u5bf9\u767b\u8bb0\u8868\u8fdb\u884c\u5e7f\u6cdb\u641c\u7d22\u540e\uff0c\u627e\u5230\u4e86\u5408\u9002\u7684\u6350\u8d60\u8005\u3002\u867d\u7136\u4f9b\u8005\u7684HLA\u4e0e\u5979\u76f8\u5408\uff0c\u4f46\u7531\u4e8e\u5fae\u5c0f\u7684\u6297\u539f\u4e0d\u76f8\u5bb9\uff0c\u4f9d\u7136\u5b58\u5728GVHD\u7684\u98ce\u9669\uff0c\u5728\u63a5\u53d7\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u4f7f\u7528\u73af\u5b62\u7d20\u9884\u9632\u4e866\u5468\u3002\u5e78\u8fd0\u7684\u662f\uff0c\u5979\u7684\u6dcb\u5df4\u7624\u6ca1\u6709\u590d\u53d1\uff0c\u4e5f\u6ca1\u6709\u53d1\u5c55\u6210GVHD\u3002\u7136\u800c\uff0c\u53d1\u751f\u4e86\u4e00\u7cfb\u5217\u7684\u611f\u67d3\u3002<\/p>\n

\u9884\u5904\u7406\u3001GVHD\u9884\u9632\u548c\u5e72\u7ec6\u80de\u79fb\u690d\u672c\u8eab\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u514d\u75ab\u6291\u5236\uff0c\u6240\u4ee5\u8fd9\u4e9b\u60a3\u8005\u6b7b\u4ea1\u7684\u6700\u5e38\u89c1\u539f\u56e0\u662f\u7531\u4e8e\u514d\u75ab\u7f3a\u9677\u800c\u5bfc\u81f4\u7684\u611f\u67d3\u3002Fig. 34.7<\/span>\u663e\u793a\u4e86\u514d\u75ab\u91cd\u5efa\u662f\u5982\u4f55\u53d1\u751f\u7684\uff0c\u4ee5\u53ca\u7279\u5b9a\u611f\u67d3\u662f\u5982\u4f55\u53d1\u751f\u7684\u3002<\/p>\n<\/section>\n<\/section>\n

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Fig. 34.7 <\/span>\u9aa8\u9ad3\u79fb\u690d\u540e\u611f\u67d3\u7684\u98ce\u9669\u3002CMV\uff0c\u5de8\u7ec6\u80de\u75c5\u6bd2\uff1bEBV\uff0c\u7231\u6cfc\u65af\u5766-\u5df4\u5c14\u75c5\u6bd2\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/p>\n


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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: <\/span>Genetics and Immunology: <\/span><\/section>\n

Peptide-Based Therapeutic Cancer <\/span>V<\/span>accines<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Maria Agarwal and Cornelia Trimble<\/span><\/section>\n
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\u7ffb\u8bd1 |  \u949f\u96ea\u83b9 \u9648\u8389\u8679 \u8d75\u6db5<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u7f57\u4f73\u4f73<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u848b\u4fca\u535a \u5b8b\u4e50<\/span><\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/section>\n

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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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OncoLab\u5b66\u672f\u661f\u7403<\/strong>\u73b0\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9<\/strong>\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

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