{"id":4638,"date":"2022-10-23T16:40:40","date_gmt":"2022-10-23T08:40:40","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2022\/10\/23\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac14%e7%ab%a0%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%a4%9a%e8%82%bd%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%a7%e8%82%bf%e7%98%a4%e7%96%ab%e8%8b%97%ef%bc%88\/"},"modified":"2022-10-23T16:40:40","modified_gmt":"2022-10-23T08:40:40","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac14%e7%ab%a0%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%a4%9a%e8%82%bd%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%a7%e8%82%bf%e7%98%a4%e7%96%ab%e8%8b%97%ef%bc%88","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2022\/10\/23\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac14%e7%ab%a0%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%a4%9a%e8%82%bd%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%a7%e8%82%bf%e7%98%a4%e7%96%ab%e8%8b%97%ef%bc%88\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c14\u7ae0\uff1a\u57fa\u4e8e\u591a\u80bd\u7684\u6cbb\u7597\u6027\u80bf\u7624\u75ab\u82d7\uff08\u4e0a\uff09"},"content":{"rendered":"
\n
\n
\n
\n
\n
\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

14.1 \u5f15\u8a00<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u81ea\u4ece\u53d1\u73b0MHC\u5448\u9012\u7684\u86cb\u767d\u8d28\u7247\u6bb5(\u591a\u80bd)\u662fT\u7ec6\u80de\u8bc6\u522b\u6297\u539f\u7684\u57fa\u7840\u540e\uff0c\u4eba\u4eec\u5bf9\u5229\u7528\u591a\u80bd\u8bf1\u5bfcT\u7ec6\u80de\u53cd\u5e94\u7684\u6cbb\u7597\u65b9\u6cd5\u5c31\u4ea7\u751f\u4e86\u6781\u5927\u7684\u5174\u8da3\u3002<\/p>\n

CD8+ <\/sup>T\u7ec6\u80de\uff08Tc\uff09<\/strong>\u53ef\u4ee5\u8bc6\u522b\u7531MHC-l\u7c7b\u5206\u5b50(\u4eba\u7c7b\u7684HLA l\u7c7b)\u63d0\u5448\u7684\u6c28\u57fa\u9178\u77ed\u80bd\u3002\u8fd9\u4e9b\u77ed\u80bd\u75318-11\u4e2a<\/strong>\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u4e14\u53ef\u4ee5\u5728\u6240\u6709\u6709\u6838\u7ec6\u80de\u4e0a\u8868\u8fbe\u3002<\/p>\n

\u800cCD4+<\/sup> T\u7ec6\u80de(Th)<\/strong>\u53ef\u4ee5\u8bc6\u522b\u7531MHC-II\u7c7b\u5206\u5b50\uff08\u4eba\u7c7b\u7684HLA ll\u7c7b\uff09\u63d0\u5448\u7684\u957f\u5ea6\u4e3a12-15\u4e2a<\/strong>\u6c28\u57fa\u9178\u7684\u591a\u80bd\uff0c\u8fd9\u4e9bMHC-II\u7c7b\u5206\u5b50\u4e3b\u8981\u5728\u514d\u75ab\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u5982\u6811\u7a81\u72b6\u7ec6\u80de(DC)\u3001\u5de8\u566c\u7ec6\u80de\u548cB\u7ec6\u80de\u3002<\/p>\n

\u7531\u4e8eT\u7ec6\u80de\u53ea\u80fd\u8bc6\u522b\u7531HLA\u63d0\u5448\u7684\u6297\u539f\u7247\u6bb5(\u8868\u4f4d)\uff0c\u6240\u4ee5\u5f53\u8fd9\u4e9b\u8868\u4f4d\u88abHLA\u63d0\u5448\u5230\u7ec6\u80de\u819c\u4e0a\u65f6\uff0cT\u7ec6\u80de\u4e0d\u4f1a\u88ab\u4f53\u6db2\u4e2d\u6e38\u79bb\u7684\u6297\u539f\u6fc0\u6d3b\uff0c\u800c\u4f1a\u4e13\u95e8\u8bc6\u522b\u4e0eT\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\u7684HLA-\u6297\u539f\u80bd\u590d\u5408\u7269<\/strong>\u3002<\/p>\n

\u91cd\u8981\u7684\u662f\uff0cT\u7ec6\u80de\u53ef\u4ee5\u8bc6\u522b\u5728\u7ec6\u80de\u5185\u4efb\u610f\u4f4d\u7f6e\u8868\u8fbe\u7684\u86cb\u767d\u8d28\u7247\u6bb5\uff0c\u8fd9\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u7406\u60f3\u7684\u76d1\u6d4b\u7cfb\u7edf\uff0c\u8fd9\u4e2a\u7cfb\u7edf\u751a\u81f3\u53ef\u4ee5\u68c0\u6d4b\u7ec6\u80de\u6700\u504f\u8fdc\u4f4d\u7f6e(\u5982\u7ec6\u80de\u6838)\u7684\u86cb\u767d\u8d28\u7247\u6bb5\u3002\u56e0\u6b64\uff0cT\u7ec6\u80de\u53cd\u5e94\u53ef\u4ee5\u770b\u4f5c\u662f\u5bf9\u6297\u75c5\u539f\u4f53\u548c\u764c\u7ec6\u80de\u7684\u7279\u5f02\u6027\u9002\u5e94\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u7531\u4e8e\u8bf1\u5bfc\u514d\u75ab\u8010\u53d7\u7684\u673a\u5236\u5e76\u4e0d\u662f\u4e07\u65e0\u4e00\u5931\u7684\uff0c\u6240\u4ee5T\u7ec6\u80de\u6cbb\u7597\u4e5f\u53ef\u4ee5\u9488\u5bf9\u8fc7\u5ea6\u8868\u8fbe\u7684\u81ea\u8eab\u6297\u539f\u6216\u5206\u5316\u6297\u539f\uff0c\u4f46\u901a\u8fc7\u514d\u75ab\u8010\u53d7\u6765\u524a\u5f31\u4e0e\u8fd9\u4e9b\u6297\u539f\u6709\u5173\u7684T\u7ec6\u80de\u8c31\u7cfb\u53ef\u80fd\u4e5f\u4f1a\u5e26\u6765\u65b0\u7684\u95ee\u9898\u3002 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

14.2 \u6cbb\u7597\u6027\u80bf\u7624\u75ab\u82d7\u7684\u4f5c\u7528\u6a21\u5f0f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u80bf\u7624\u6cbb\u7597\u6027\u75ab\u82d7\u9700\u8981\u8bf1\u5bfc\u5f3a\u5927\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u53cd\u5e94\uff08CD8+ <\/sup>T\u7ec6\u80de\u53cd\u5e94\uff09\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u76ae\u4e0b\u3001\u76ae\u5185\u6216\u808c\u8089\u6ce8\u5c04\u4e0d\u540c\u7684\u75ab\u82d7\u6765\u5b9e\u73b0\uff1aDNA\u3001RNA\u3001\u5408\u6210\u7684\u957f\u80bd(SLP)\u6216\u5305\u542b\u80bf\u7624\u76f8\u5173\u6297\u539f\u5e8f\u5217\u7684\u91cd\u7ec4\u75c5\u6bd2\u3002<\/span><\/p>\n

\u6ce8\u5c04\u5230\u4f53\u5185\u7684\u75ab\u82d7\u6297\u539f\u4f1a\u88abDC\u63d0\u5448<\/strong>(\u4f8b\u5982\uff0c\u8868\u76ae\u6216\u771f\u76ae\u6811\u7a81\u72b6\u7ec6\u80de)\u3002\u7136\u540e\uff0cDC\u901a\u8fc7\u4f20\u5165\u6dcb\u5df4\u7ba1\u8fc1\u79fb\u5230\u75ab\u82d7\u5f15\u6d41\u6dcb\u5df4\u7ed3<\/strong>\uff0c\u5e76\u5b9a\u5c45\u5728\u8fd9\u4e9b\u6dcb\u5df4\u7ed3\u7684T\u7ec6\u80de\u533a\uff0c\u901a\u8fc7\u4e0eCD4+ <\/sup>T\u7ec6\u80de\u548cCD8+<\/sup> T\u7ec6\u80de<\/strong>\u9002\u5f53\u7684\u63a5\u89e6\u6765\u542f\u52a8T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n

\u6b63\u5e38\u6fc0\u6d3b\u7684T\u7ec6\u80de\u4f1a\u901a\u8fc7\u6dcb\u5df4\u7ba1\u79bb\u5f00\u6dcb\u5df4\u7ed3\uff0c\u6700\u7ec8\u901a\u8fc7\u80f8\u8154\u5bfc\u7ba1\u5230\u8fbe\u8840\u6d41\u3002\u5728\u8840\u6db2\u4e2d\uff0c\u5b83\u4eec\u6709\u4e00\u5b9a\u6982\u7387\u4f1a\u6e17\u5165\u643a\u5e26\u6297\u539f\u7684\u80bf\u7624\u90e8\u4f4d<\/span>\u3002<\/p>\n

\u901a\u5e38\u90a3\u91cc\u7684T\u7ec6\u80de\u5fc5\u987b\u5e94\u5bf9\u6076\u52a3\u7684\u5fae\u73af\u5883<\/span>\uff0c\u5305\u62ec\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg<\/span>\uff09\u3001T\u7ec6\u80de\u68c0\u67e5\u70b9\u914d\u4f53(\u5982PD-L1<\/span>)\u3001\u9ad3\u7cfb\u6291\u5236\u7ec6\u80de\uff08MDSC<\/span>\uff09\u4ee5\u53ca\u7531T\u7ec6\u80de\u91ca\u653e\u7684\u56e0\u5b50\uff0c\u5982\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u3001\u8d8b\u5316\u56e0\u5b50<\/span>\u548c\u5432\u54da\u80fa2\uff0c3-\u53cc\u52a0\u6c27\u9176(IDO<\/span>)\u3002\u800c\u8fd9\u4e9b\u56e0\u5b50\u4f1a\u635f\u5bb3T\u7ec6\u80de\u7684\u8fc1\u79fb\u3001\u589e\u6b96\u53ca\u529f\u80fd(Fig 14.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig. 14.1 <\/span> \u4eba\u5de5\u5408\u6210\u957f\u80bd\uff08SLP\uff09\u75ab\u82d7\u7684\u4f5c\u7528\u65b9\u5f0f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

SLP\u80fd\u6709\u6548\u5730\u8fd0\u9001\u80bf\u7624\u76f8\u5173\u6297\u539f\uff0c\u5e76\u4e14\u5728\u75ab\u82d7\u6ce8\u5c04\u533a\u5f88\u5bb9\u6613\u63a5\u89e6\u5230DC\u3002\u643a\u5e26\u6297\u539f\u7684DC\u901a\u8fc7\u4f20\u5165\u6dcb\u5df4\u7ba1\u8fc1\u79fb\u5230\u75ab\u82d7\u5f15\u6d41\u6dcb\u5df4\u7ed3\uff0c\u8fdb\u5165\u76ae\u8d28\u65c1T\u7ec6\u80de\u533a\u57df\uff0c\u5728\u90a3\u91cc\u7ee7\u7eed\u5bf9\u6444\u5165SLP\u7684\u6297\u539f\u8fdb\u884c\u5904\u7406\uff0c\u4e4b\u540e\u5b83\u4eec\u5c06\u6297\u539f\u5448\u9012\u7ed9CD4+<\/sup>\u548cCD8+<\/sup> T\u7ec6\u80de\uff0c\u6fc0\u6d3bT\u7ec6\u80de\u3002<\/p>\n

\u6d3b\u5316\u7684T\u7ec6\u80de\u901a\u8fc7\u4f20\u51fa\u6dcb\u5df4\u7ba1\u79bb\u5f00\u6dcb\u5df4\u7ed3\uff0c\u90e8\u5206\u8fc1\u79fb\u5230\u80bf\u7624\u4e2d\u80bf\u7624\u6297\u539f\u8868\u8fbe\u7684\u90e8\u4f4d\u3002\u5728\u90a3\u91cc\u6fc0\u6d3b\u7684T\u7ec6\u80de\u4f1a\u9762\u4e34\u6076\u52a3\u7684\u80bf\u7624\u73af\u5883\uff0c\u5176\u4e2d\u5305\u62ec\u5bf9T\u7ec6\u80de\u4e0d\u5229\u7684\u7ec6\u80de\u6210\u5206\uff0c\u5982\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u7ec6\u80de(MDSC)\u548cTreg\uff0c\u4ee5\u53ca\u514d\u75ab\u6291\u5236\u8d8b\u5316\u56e0\u5b50\u548c\u7ec6\u80de\u56e0\u5b50\uff0cIDO\u9176\u7684\u8868\u8fbe\uff0c\u4ee5\u53ca\u6291\u5236T\u7ec6\u80de\u68c0\u67e5\u70b9\u7684\u914d\u4f53\uff0c\u5982PD-1\u548cLAG-3\u3002\u8fd9\u4e9b\u60c5\u51b5\u5171\u540c\u635f\u5bb3T\u7ec6\u80de\u7684\u8fc1\u79fb\u3001\u529f\u80fd\u548c\u6269\u589e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

14.3 \u4ec0\u4e48\u624d\u662f\u4e00\u79cd\u597d\u7684\u80bf\u7624\u6cbb\u7597\u6027\u75ab\u82d7\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6211\u4eec\u56de\u987e\u4e86\u51b3\u5b9a\u80bf\u7624\u75ab\u82d7\u6210\u8d25\u7684\u56e0\u7d20<\/strong>\u3002\u603b\u7ed3\u51fa\u6210\u529f\u7684\u80bf\u7624\u75ab\u82d7\u5fc5\u987b\u6ee1\u8db3\u4e0b\u5217\u56db\u4e2a\u8981\u6c42\uff1a<\/p>\n

(1)\u9009\u62e9\u6b63\u786e\u7684\u80bf\u7624\u6297\u539f<\/span>\uff0c<\/p>\n

(2)\u9009\u62e9\u6709\u6548\u7684\u75ab\u82d7\u5e73\u53f0<\/span>\uff0c<\/p>\n

(3)\u4f7f\u7528\u9002\u5f53\u7684\u75ab\u82d7\u4f50\u5242<\/span>\uff0c<\/p>\n

(4)\u7ed3\u5408\u9002\u5f53\u7684\u8054\u5408\u6cbb\u7597<\/span>\u4f7f\u7528\u3002<\/p>\n

Table14.1<\/span>\u5217\u51fa\u4e86\u80bf\u7624\u75ab\u82d7\u6210\u529f\u7684\u5173\u952e\u56e0\u7d20\u548c\u76f8\u5e94\u7684\u9009\u62e9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 14.1 <\/span>\u6cbb\u7597\u6027\u764c\u75c7\u75ab\u82d7\u6210\u529f\u5f00\u53d1\u7684\u5173\u952e\u56e0\u7d20<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u6297\u539f\u7684\u9009\u62e9<\/span><\/strong>\u4e0a\uff0c\u4f18\u5148\u9009\u62e9\u4e0d\u53d7\u80f8\u817a\u5185\u514d\u75ab\u8010\u53d7\u673a\u5236\u5f71\u54cd\u7684\u76f8\u5173\u80bf\u7624\u6297\u539f\uff0c\u5c24\u5176\u662f\u7531\u4eba\u7c7b\u4e73\u5934\u7624\u75c5\u6bd2(HPV)\u3001\u7231\u6cfc\u65af\u5766-\u5df4\u5c14\u75c5\u6bd2(Epstein-Barr Virus)\u3001\u4eba\u7c7b\u55dcT\u7ec6\u80de\u75c5\u6bd2I(HTLV-I)\u3001\u4e59\u809d\u75c5\u6bd2\u3001\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u3001\u5361\u6ce2\u897f\u8089\u7624\u75c5\u6bd2(KSV)\u548c\u9ed8\u514b\u5c14\u7ec6\u80de\u764c\u75c5\u6bd2\u7b49\u764c\u75c7\u75c5\u6bd2\u7f16\u7801\u7684\u6297\u539f\u3002<\/p>\n

\u5168\u4e16\u754c\u5927\u7ea620%\u7684\u764c\u75c7\u662f\u7531\u75c5\u6bd2\u5f15\u8d77\u7684\u3002\u800c\u5728\u5f15\u8d77\u4eba\u7c7b\u764c\u75c7\u7684\u539f\u56e0\u4e2d\u5360\u6bd4\u66f4\u5927\u7684\u662f\u7684\u4e00\u79cd\u65b0\u7684\u3001\u975e\u5e38\u91cd\u8981\u7684\u6297\u539f\u7c7b\u522b\uff0c\u5b83\u4eec\u5305\u62ec\u5728\u9999\u70df\u70df\u96fe\u4e2d\u7684\u5316\u5b66\u81f4\u764c\u7269(\u80ba\u764c\u3001H&N\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u8180\u80f1\u764c)\u3001\u7d2b\u5916\u7ebf(\u9ed1\u8272\u7d20\u7624\u548c\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c)\u6216DNA\u4fee\u590d\u7f3a\u9677(\u4f8b\u5982\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u7684\u7ed3\u76f4\u80a0\u764c)\u5f15\u8d77\u7684\u764c\u7ec6\u80de\u7a81\u53d8\u4ea7\u751f\u7684\u65b0\u6297\u539f<\/span>\u3002<\/p>\n

\u8fd9\u4e9b\u65b0\u6297\u539f\u662f\u764c\u75c7\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u9ad8\u6548\u9776\u70b9\uff0c\u53d1\u73b0\u5176\u91cd\u8981\u6027\u6e90\u4e8e\u4eba\u4eec\u89c2\u5bdf\u5230\u9488\u5bf9CTLA-4\u6216PD-1\u7684\u68c0\u67e5\u70b9\u963b\u65ad\u5355\u6297\u7684\u4e34\u5e8a\u7597\u6548\u4e0e\u4e2a\u4f53\u60a3\u8005\u764c\u75c7\u7a81\u53d8\u6570\u91cf\u4e4b\u95f4\u6709\u663e\u8457\u76f8\u5173\u6027\u3002\u5728\u4e00\u540d\u60a3\u8005\u4e2d\uff0c\u9488\u5bf9\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7a81\u53d8\u7684CD8+<\/sup> T\u7ec6\u80de\u589e\u6b96\u4e0e\u4f7f\u7528\u6297CTLA-4\u6297\u4f53\u7684\u6cbb\u7597\u6210\u529f\u6709\u5173\u3002<\/p>\n

\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5df2\u7ecf\u9884\u6d4b\u5e76\u9a8c\u8bc1\u6709\u53ef\u80fd\u53d1\u751f\u7a81\u53d8\u7684\u65b0\u6297\u539f\uff0c\u5e76\u5c06\u5c0f\u9f20\u6210\u529f\u5730\u63a5\u79cd\u4e86\u542b\u6709\u65b0\u6297\u539f\u7684SLP\u6216RNA\u75ab\u82d7\u3002\u76ee\u524d\u8f83\u53d7\u6b22\u8fce\u7684\u80bf\u7624\u75ab\u82d7\u6210\u5206\u662f\u75c5\u6bd2\u7684\u975e\u81ea\u8eab\u6297\u539f\u548c\u7a81\u53d8\u884d\u751f\u7684\u65b0\u6297\u539f\u7247\u6bb5\uff0c\u4f46\u9488\u5bf9\u8bb8\u591a\u8fc7\u8868\u8fbe\u7684\u80bf\u7624-\u777e\u4e38\u6297\u539f\u3001\u5206\u5316\u6297\u539f\u3001Survivin\u3001Wilms Tumor 1(WT1)\u3001\u91ce\u751f\u578b\u6216\u7a81\u53d8\u578bP53\u548c\u95f4\u786b\u86cb\u767d\u7684T\u7ec6\u80de\u8c31\u7cfb\u53ef\u80fd\u4e5f\u5177\u6709\u8bf1\u5bfc\u5f3a\u5927\u7684CD8+<\/sup>  T\u7ec6\u80de\u53cd\u5e94\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

14.4  \u57fa\u4e8eT\u7ec6\u80de\u8868\u4f4d\u7684\u75ab\u82d7\u63a5\u79cd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7ecf\u5178\u7684\u9884\u9632\u6027\u75ab\u82d7\u7531\u70ed\u706d\u6d3b\u6216\u51cf\u6bd2\u7684\u5fae\u751f\u7269\u7ec4\u6210\uff0c\u8fd9\u4e9b\u5fae\u751f\u7269\u8868\u8fbe\u7684\u6298\u53e0\u86cb\u767d\uff0c\u53ef\u4ee5\u8bf1\u5bfc\u673a\u4f53\u4ea7\u751f\u9488\u5bf9\u7279\u5b9a\u8868\u4f4d\u7684\u4fdd\u62a4\u6027\u6297\u4f53\u3002<\/p>\n

\u7136\u800c\uff0c\u6cbb\u7597\u6027\u75ab\u82d7<\/span>\u9700\u8981\u8bf1\u5bfc\u7531HLA II\u6216 I\u7c7b\u5206\u5b50\u63d0\u5448\u4e14\u5177\u6709\u7279\u5b9aT\u7ec6\u80de\u8bc6\u522b\u7684\u8868\u4f4d\uff0c\u4ece\u800c\u6fc0\u6d3bCD4+<\/sup> T\u548cCD8+ <\/sup>T\u7ec6\u80de\u53cd\u5e94\u3002\u8be5\u8868\u4f4d\u53ea\u6709\u5728\u4e0eHLA II\u6216 I\u7c7b\u5206\u5b50\u7ed3\u5408\u65f6\u624d\u5177\u6709\u6b63\u786e\u7684\u6784\u8c61<\/span>\u3002\u56e0\u6b64\uff0c\u7528\u4e8e\u8bf1\u5bfcT\u7ec6\u80de\u53cd\u5e94\u7684\u591a\u80bd\u75ab\u82d7\u7684\u7ec4\u6210\u8868\u4f4d\u5305\u62ec\u5177\u6709\u51c6\u786e\u957f\u5ea6\u7684\u80bd(\u77ed\u80bd\uff09\uff0c\u6216\u5305\u542b\u4e00\u4e2a\u6216\u591a\u4e2a\u8868\u4f4d\u7684\u8f83\u957f\u7684\u80bd(\u5408\u6210\u957f\u80bd\uff0cSLP)\uff0c\u4f46\u8fd9\u4e9b\u80bd\u8fd8\u9700\u8981DC\u8fdb\u4e00\u6b65\u5904\u7406\uff0c\u4ee5\u4fbf\u5c06\u7cbe\u786e\u7684\u8868\u4f4d\u6b63\u786e\u5730\u7ed3\u5408\u5230HLA\u5206\u5b50\u4e0a\u3002<\/p>\n

\u5b8c\u5168\u5339\u914d\u7684\u77ed\u80bd\u548cSLP\u90fd\u5df2\u7528\u4e8e\u6cbb\u7597\u6027\u75ab\u82d7\uff0c\u4f46\u76f8\u6bd4\u4e4b\u4e0b\uff0cSLP\u66f4\u53d7\u6b22\u8fce\u3002\u57fa\u4e8eT\u7ec6\u80de\u8868\u4f4d\u75ab\u82d7\u7684\u4e00\u4e2a\u4f18\u70b9\u662f\u53ea\u9700\u8981\u8868\u8fbe\u8be5\u8868\u4f4d\u4e30\u5bcc\u533a\u57df\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u800c\u53ef\u4ee5\u5ffd\u7565\u5927\u91cf\u4e0d\u5305\u542b\u7684T\u7ec6\u80de\u8868\u4f4d\u7684\u86cb\u767d\u8d28\u7247\u6bb5\u3002<\/p>\n

\u9664\u4e86\u514d\u75ab\u6c89\u9ed8\u7684\u5e8f\u5217\u5916\uff0cDC\u5bf9\u86cb\u767d\u8d28\u7684\u5904\u7406\u6548\u679c\u4e5f\u5f88\u5dee<\/span>\uff0c\u5dee\u5230\u4e0d\u8db3\u4ee5\u5c06\u5176\u5448\u9012\u7ed9T\u7ec6\u80de\uff08\u7279\u522b\u662fCD8+<\/sup> T\u7ec6\u80de\uff09\u3002\u800cSLP\u80fd\u88abDC\u6709\u6548\u5730\u5904\u7406<\/span>\uff0c\u5e76\u5206\u522b\u5448\u9012\u7ed9CD4+ <\/sup>T\u548cCD8+ <\/sup>T\u7ec6\u80de\u3002<\/p>\n

\u5728\u5408\u6210SLP\u75ab\u82d7\u65f6\uff0c\u5173\u952e\u662f\u8981\u5305\u62ec\u80fd\u591f\u4e0e\u6700\u5e38\u89c1\u7684HLA I\u548cII\u7c7b\u5206\u5b50\u7ed3\u5408\u7684\u8868\u4f4d\u3002\u4e3a\u6b64\uff0c\u5728\u591a\u80bd\u75ab\u82d7\u4e2d\u8fd8\u9700\u8981\u6709\u8db3\u591f\u957f\u5ea6\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u6765\u5bb9\u7eb3\u6700\u5e38\u89c1\u7684HLA I\u548cII\u7c7b\u5206\u5b50\u7684\u7ed3\u5408\u57fa\u5e8f\u5217\uff0c\u8fd9\u4e0e\u80de\u6d46\u4e2d\u7684\u86cb\u767d\u9176\u4f53<\/span>\u5904\u7406\u591a\u80bd\u75ab\u82d7\u7684\u80fd\u529b\u76f8\u5173\uff0c\u80de\u6d46\u4e2d\u7ecf\u8fc7\u5904\u7406\u540e\u7684\u591a\u80bd\u75ab\u82d7\u53ef\u4ee5\u901a\u8fc7\u6297\u539f\u5904\u7406\u8f6c\u8fd0\u4f53(TAP)<\/span>(HLA I\u7c7b\u5904\u7406\u9014\u5f84<\/span>)\u8fdb\u884c\u8f6c\u8fd0\uff0c\u6216\u8005\u901a\u8fc7DC\u5185\u4f53<\/span>\u4e2d\u7684\u7ec4\u7ec7\u86cb\u767d\u9176(HLA II\u7c7b\u5904\u7406\u9014\u5f84)<\/span>\u8fdb\u884c\u5904\u7406\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

14.5 \u77ed\u80bd\u4e0e\u957f\u80bd\u5728\u80bf\u7624\u75ab\u82d7\u4e2d\u7684\u6bd4\u8f83<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u591a\u80bd\u75ab\u82d7\u7684\u6700\u521d\u5c1d\u8bd5\u53ea\u6d89\u53ca\u5c0f\u9f20\u4f53\u5185\u5355\u4e00\u7684MHC I\u7c7b\u7ed3\u5408\u8868\u4f4d+\u4f50\u5242\u3002\u5c3d\u7ba1\u8fd9\u79cd\u75ab\u82d7\u5728\u51e0\u4e2a\u5b9e\u4f8b\u4e2d\u90fd\u663e\u793a\u51fa\u6297\u75c5\u6bd2\u6216\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4f46\u8fd9\u79cd\u77ed\u80bd\u75ab\u82d7<\/span><\/strong>(<15\u4e2a\u6c28\u57fa\u9178)\u663e\u7136\u4e0d\u662f\u6700\u4f18\u9009\u62e9<\/span>\uff0c\u5176\u4e2d\u7684\u539f\u56e0\u6709\u5f88\u591a\u3002\u9996\u5148\uff0c\u77ed\u80bd\u53ef\u4ee5\u76f4\u63a5\u4e0e\u6240\u6709<\/span>\u6709\u6838\u7ec6\u80de\u7684HLA I\u7c7b\u5206\u5b50\u7ed3\u5408\uff0c\u800c\u4e0d\u9700\u8981\u8fdb\u884c\u6297\u539f\u5904\u7406<\/span>\u3002<\/p>\n

\u56e0\u6b64\uff0c\u5728\u7f3a\u4e4f\u5171\u523a\u6fc0\u5206\u5b50\u7684\u60c5\u51b5\u4e0b\uff0c\u75ab\u82d7\u77ed\u80bd\u5728\u975e\u4e13\u4e1a\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u7684HLA I\u7c7b\u5206\u5b50\u4e2d\u6d53\u5ea6\u8f83\u9ad8<\/span>\uff0c\u4f1a\u5bfc\u81f4\u77ed\u6682\u7684CD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u751a\u81f3CD8+<\/sup>T\u7ec6\u80de\u8010\u53d7<\/span>\u3002<\/p>\n

\u77ed\u80bd\u75ab\u82d7\u7684\u7b2c\u4e8c\u4e2a\u7f3a\u70b9<\/span>\u662f\u7f3a\u4e4f\u6fc0\u6d3bCD4+<\/sup>T\u7ec6\u80de<\/span>\u7684 II\u7c7b\u8868\u4f4d\u3002\u800cCD4+<\/sup>T\u7ec6\u80de\u5728\u8bf1\u5bfc\u548c\u7ef4\u6301\u6700\u4f73\u7684CD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u4ee5\u53ca\u4fc3\u8fdbCD8+<\/sup>T\u8bb0\u5fc6\u7ec6\u80de\u7684\u4ea7\u751f\u4e2d\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\uff0c\u5e76\u4e14CD4+<\/sup>T\u7ec6\u80de\u672c\u8eab\u53ef\u4ee5\u53d1\u6325\u91cd\u8981\u7684\u6297\u75c5\u6bd2\u6216\u6297\u80bf\u7624\u529f\u80fd\u3002<\/p>\n

\u6b64\u5916\uff0c\u63a5\u79cd\u7528\u4e0d\u5b8c\u5168\u5f17\u6c0f\u4f50\u5242(IFA)\u914d\u5236\u7684\u77ed\u80bd\u75ab\u82d7\u4f1a\u5bfc\u81f4T\u7ec6\u80de\u53cd\u5e94\u51cf\u5f31\uff0c\u4ea7\u751f\u8fd9\u79cd\u73b0\u8c61\u7684\u539f\u56e0\u4e00\u90e8\u5206\u662f\u4e0a\u8ff0\u7684\u4e24\u70b9\uff0c\u53e6\u4e00\u90e8\u5206\u662f\u7531\u4e8e\u7528IFA\u914d\u5236\u7684\u77ed\u80bd\u4f1a\u4f7fT\u7ec6\u80de\u79fb\u52a8\u5230\u63a5\u79cd\u75ab\u82d7\u90e8\u4f4d<\/span>\u800c\u4e0d\u662f\u80bf\u7624\u90e8\u4f4d\u3002<\/p>\n

\u76f8\u53cd\uff0c\u7528SLP<\/strong>(>20\u4e2a\u6c28\u57fa\u9178\u957f\u5ea6)\u63a5\u79cd<\/span>\uff0c\u800c\u4e0d\u662f\u7528IFA\u6216\u76f8\u5173\u4f50\u5242Montanide ISA-51\u914d\u5236\u7684\u77ed\u80bd\u63a5\u79cd\uff0c\u4f1a\u8bf1\u5bfc\u6301\u7eed\u7684<\/span>CD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u548c\u5f3a\u5927\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u63a5\u79cd\u7528IFA\u6216Montanide\u914d\u5236\u7684SLP\u75ab\u82d7\u4e5f\u80fd\u4f7f\u764c\u75c7\u75c5\u53d8\u524d\u6216\u764c\u75c7\u60a3\u8005\u4f53\u5185\u7ef4\u6301\u5f3a\u5927\u800c\u6301\u7eed\u7684CD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u548c\u8bb0\u5fc6T\u7ec6\u80de\u53cd\u5e94<\/span>\u3002<\/p>\n

\u4f7f\u7528\u6210\u719f\u7684DC\u514d\u75ab\u6ce8\u5c04\u524d\uff0c\u5728\u4f53\u5916\u8d1f\u8f7d\u4e00\u5b9a\u7a0b\u5ea6\u7684\u77ed\u80bd\u6216\u7528\u6297CD40\u7684\u6fc0\u52a8\u578b\u6297\u4f53\u4ee5\u66ff\u4ee3CD4+<\/sup>T\u7ec6\u80de\u4fe1\u53f7\uff0c\u518d\u52a0\u4e0a\u6216\u4e0d\u52a0TLR3\u914d\u4f53PolyI:C\uff0c\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u514b\u670d\u77ed\u80bd\u8bf1\u5bfc\u7684\u8010\u53d7\u3002<\/p>\n

\u5728\u76ae\u4e0b\u6216\u4f53\u5916\u6ce8\u5c04SLP\u540e\uff0cDC<\/strong>\u80fd\u591f\u6709\u6548\u5730\u5904\u7406SLP\uff0c\u4ece\u800c\u9ad8\u6548\u5730\u5c06SLP\u5448\u9012\u7ed9MHC I\u7c7b\u548cII\u7c7b\u5206\u5b50\u3002\u6b64\u5916\uff0cDC\u5bf9\u88abMHC I\u6216II\u7c7b\u5206\u5b50\u63d0\u5448\u7684SLP\u7684\u5904\u7406\u6bd4\u5bf9\u86cb\u767d\u8d28\u7684\u5904\u7406\u66f4\u9ad8\u6548\u3002SLP\u80fd\u591f\u5728\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u73af\u5883\u4e2d\u8bf1\u5bfc\u5f3a\u5927\u7684CD4+<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94<\/span>\uff0c\u800c\u63a5\u79cd\u5b8c\u6574\u86cb\u767d\u75ab\u82d7\u4e0e\u663e\u8457\u7684CD4+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u6709\u5173\uff0c\u4f46\u4e0eCD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u65e0\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 |<\/span> Oncoimmunology: A Practical Guide <\/span><\/section>\n
for Cancer Immunotherapy<\/span><\/section>\n
<\/span><\/section>\n
<\/span><\/section>\n
\u4f5c\u8005 | Cornelis J.M. Melief<\/span><\/span><\/section>\n
\u7ffb\u8bd1 | \u90d1\u68a6\u6021 \u7ae0\u9707 \u7f57\u4f73\u4f73<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u674e\u5b89\u742a<\/span><\/span><\/span><\/section>\n
\u521d\u5ba1 | \u4efb\u632f\u9633 \u5ed6\u5a9b<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

<\/section>\n

<\/section>\n

\u2589  \u5f3a\u70c8\u63a8\u8350<\/strong><\/strong><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n

\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u672c\u516c\u4f17\u53f7\u4e0a\u7684\u5f80\u671f\u6587\u7ae0\u540c\u6b65\u53d1\u5e03\u81f3\u5bf9\u5e94\u7f51\u7ad9OncoLab\u5b9e\u9a8c\u5ba4\u3002<\/p>\n

\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u5b66\u672f\u5bfc\u822a<\/strong><\/strong><\/p>\n

\n
\n
\n
\n
\n

\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

\n
\n
\n
\n

OncoLab\u5b66\u672f\u661f\u7403<\/strong>\u73b0\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9<\/strong>\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

<\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n

<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n

\u7528\u4e8eOncoLab\u8bfb\u8005\u4ea4\u6d41\u4e92\u52a9\u6c38\u4e45\u514d\u8d39
<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/section>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

14.1 \u5f15\u8a00 \u81ea\u4ece\u53d1\u73b0MHC\u5448\u9012\u7684\u86cb\u767d\u8d28\u7247\u6bb5(\u591a\u80bd)\u662fT\u7ec6\u80de\u8bc6\u522b\u6297\u539f\u7684\u57fa\u7840\u540e\uff0c\u4eba\u4eec\u5bf9\u5229\u7528\u591a\u80bd\u8bf1\u5bfcT\u7ec6\u80de\u53cd\u5e94\u7684\u6cbb\u7597\u65b9\u6cd5\u5c31\u4ea7\u751f\u4e86\u6781\u5927\u7684\u5174\u8da3\u3002 CD8+ T\u7ec6\u80de\uff08Tc\uff09\u53ef\u4ee5\u8bc6…<\/p>\n","protected":false},"author":1,"featured_media":4634,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/4638"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=4638"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/4638\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/4634"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=4638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=4638"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=4638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}