{"id":4749,"date":"2022-11-02T12:23:09","date_gmt":"2022-11-02T04:23:09","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2022\/11\/02\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac14%e7%ab%a0%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%a4%9a%e8%82%bd%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%a7%e8%82%bf%e7%98%a4%e7%96%ab%e8%8b%97%ef%bc%88-2\/"},"modified":"2022-11-02T12:23:09","modified_gmt":"2022-11-02T04:23:09","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac14%e7%ab%a0%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%a4%9a%e8%82%bd%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%a7%e8%82%bf%e7%98%a4%e7%96%ab%e8%8b%97%ef%bc%88-2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2022\/11\/02\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac14%e7%ab%a0%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%a4%9a%e8%82%bd%e7%9a%84%e6%b2%bb%e7%96%97%e6%80%a7%e8%82%bf%e7%98%a4%e7%96%ab%e8%8b%97%ef%bc%88-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c14\u7ae0\uff1a\u57fa\u4e8e\u591a\u80bd\u7684\u6cbb\u7597\u6027\u80bf\u7624\u75ab\u82d7\uff08\u4e0b\uff09"},"content":{"rendered":"
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14.6 \u5176\u4ed6\u75ab\u82d7\u63a5\u79cd\u7684\u5f62\u5f0f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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DC\u7ec6\u80de\u662f\u5426\u80fd\u6709\u6548\u5730\u5c06\u6297\u539f\u901a\u8fc7HLA I\u7c7b\u548cII\u7c7b\u5206\u5b50\u8fdb\u884c\u5448\u9012\u5bf9\u4e8e\u6cbb\u7597\u6027\u75ab\u82d7\u7684\u6cbb\u7597\u6548\u679c\u80fd\u5426\u6210\u529f\u5177\u6709\u5341\u5206\u91cd\u8981\u7684\u610f\u4e49\u3002<\/strong><\/p>\n

\u9664\u4e86SLP(\u5408\u6210\u7684\u957f\u80bd)<\/strong>\uff0cDNA<\/strong>\u548cRNA<\/strong>\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u8bf1\u5bfc\u6cbb\u7597\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u6709\u6548\u65b9\u5f0f\u3002DNA\u75ab\u82d7\u901a\u5e38\u662f\u901a\u8fc7\u7535\u7a7f\u5b54\u6cd5\u8fdb\u884c\u63a5\u79cd\uff08\u5982\u4e24\u79cd\u9488\u5bf9\u7531\u9ad8\u5371HPV16\u5f15\u8d77\u7684\u75c5\u53d8\u7684\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u3002\u800c\u5bf9\u4e8eRNA\u75ab\u82d7\u63a5\u79cd\uff0c\u80fd\u5728\u9633\u79bb\u5b50\u8102\u8d28\u4f53\u4e2d\u4f20\u9012\u80bf\u7624\u6297\u539f\u7f16\u7801\u7684RNA\uff0c\u5c31\u662f\u4e00\u4e2a\u6210\u529f\u7684RNA\u5e73\u53f0\u3002<\/p>\n

\u540c\u65f6\uff0c\u6cbb\u7597\u6027\u75ab\u82d7\u4e5f\u53ef\u4ee5\u5229\u7528\u75c5\u6bd2\u8f7d\u4f53\uff0c\u867d\u7136\u75c5\u6bd2\u8f7d\u4f53\u81ea\u8eab\u5305\u542b\u7684\u8f7d\u4f53\u5e8f\u5217\u4e0e\u63d2\u5165\u7684\u80bf\u7624\u6297\u539f\u4e4b\u95f4\u5b58\u5728\u6297\u539f\u7ade\u4e89\uff0c\u4f46\u8fd9\u4e2a\u95ee\u9898\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u901a\u8fc7\u4f7f\u7528\u4e24\u79cd\u4e0d\u540c\u7684\u75c5\u6bd2\u8f7d\u4f53\u542f\u52a8\u548c\u589e\u5f3a\u6765\u514b\u670d\u3002\u514d\u75ab\u53cd\u5e94\u4e0e\u63d2\u5165\u7684\u80bf\u7624\u6297\u539f\u5728\u589e\u5f3a\u6c34\u5e73\u4e0a\u53d1\u751f\u4ea4\u53c9\u53cd\u5e94\uff0c\u4f46\u4e0d\u50cf\u9488\u5bf9\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f(PSA)\u7684\u6cbb\u7597\u6027\u75ab\u82d7PROSTVAC\u90a3\u6837\u5728\u8f7d\u4f53\u6c34\u5e73\u4e0a\u53d1\u751f\u4ea4\u53c9\u53cd\u5e94\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u5728\u6709\u5173\u6052\u6cb3\u7334HIV\u7684\u5b9e\u9a8c\u4e2d\uff0c\u7531HIV\u7684\u6297\u539f\u4fdd\u5b88\u5e8f\u5217\u7f16\u7801\u7684\u590d\u5236\u80fd\u529b\u6781\u5f3a\u7684\u75d8\u75c5\u6bd2(NYV AC-C-KC)\u542f\u52a8SLP\u540e\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u589e\u5f3aCD4\uff0b<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14.7 SLP\u75ab\u82d7\u7684\u6548\u679c\u53d6\u51b3\u4e8e\u6709\u6548\u4f50\u5242\u7684\u6dfb\u52a0<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u867d\u7136SLP\u5f88\u5bb9\u6613\u901a\u8fc7\u6811\u7a81\u72b6\u7ec6\u80de\u7684MHC I\u548cII\u7c7b\u9014\u5f84\u8fdb\u884c\u63d0\u5448\uff0c\u4f46\u6811\u7a81\u72b6\u7ec6\u80de\u8fd8\u9700\u8981\u4e00\u79cd\u5f3a\u529b\u7684\u4f50\u5242<\/span>\u5c06\u5176\u6fc0\u6d3b\u6210\u4e3a\u6210\u719f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u8be5\u4f50\u5242\u4e0d\u4ec5\u8868\u8fbe\u9002\u5f53\u7684HLA\u80bd\u590d\u5408\u4f53\uff0c\u8fd8\u53ef\u4ee5\u8bf1\u5bfc\u6548\u5e94\u6027\u548c\u8bb0\u5fc6 \u6027CD4+<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u4ea7\u751f\u53cd\u5e94\u6240\u9700\u7684\u5171\u523a\u6fc0\u5206\u5b50<\/span>\u3002<\/p>\n

\u5f53\u524d\u6709\u8be5\u4f5c\u7528\u7684\u4f50\u5242\u6709Poly I:ClC(TLR3\u914d\u4f53)<\/span>\u3001CpG(TLR9\u914d\u4f53)<\/span>\u3001\u5f17\u6c0f\u4e0d\u5b8c\u5168\u4f50\u5242\uff08\u5982\uff1aMontanide ISA-51\u6216\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u86cb\u767d\uff08STING\uff09\u6fc0\u52a8\u5242\uff09\u3002<\/p>\n

\u901a\u8fc7\u5171\u4ef7\u5076\u8054\u5c06TLR\u914d\u4f53\uff08\u5982CpG\u6216Pam3Cys\uff09\u8fde\u63a5\u5230SLP\u4e0a\uff0c\u53ef\u8fdb\u4e00\u6b65\u589e\u5f3aSLP\u75ab\u82d7\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14.8 SLP\u75ab\u82d7\u5728\u764c\u524d\u75be\u75c5\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u7597\u6548<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u63a5\u79cdSLP\u75ab\u82d7\u540e\u4f3c\u4e4e\u975e\u5e38\u6709\u6548\u5730\u6839\u9664\u4e86\u7531\u9ad8\u5371HPV16\u5f15\u8d77\u7684\u764c\u524d\u75c5\u53d8\uff0c\u5927\u7ea650%\u7684\u5bab\u9888\u764c\u548c\u5927\u591a\u6570HPV\u9633\u6027\u7684\u5934\u9888\u764c\u662f\u7531HPV16\u5f15\u8d77\u7684\u3002\u6211\u4eec\u5728\u5bf9\u4e00\u79cd\u7531HPV16\u5f15\u8d77\u7684\u5916\u9634\u764c\u524d\u75be\u75c5\u2014\u2014\u5916\u9634\u4e0a\u76ae\u5185\u7624\u53d8\u7684\u7814\u7a76\u4e2d\uff0c\u8bf1\u5bfc\u5f3a\u70c8\u7684CD4+<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u540e\uff0c\u7ed9\u60a3\u8005\u4ee5\u6bcf\u80bd300\u03bcg\u7684\u5242\u91cf\u6df7\u5408\u77ff\u7269\u6cb9\u4f50\u5242Montanide ISA-51\u8fdb\u884c\u76ae\u4e0b\u6ce8\u5c04\u4e86\u4e00\u79cd\u5305\u542b13\u4e2a\u91cd\u53e0\u7684\u957f\u80bd(25-35\u4e2a\u6c28\u57fa\u9178\u957f\uff0c\u5171\u540c\u8986\u76d6\u4e86HPV16 E6\u548cE7\u764c\u57fa\u56e0\u7ed3\u5408\u86cb\u767d\u7684257\u4e2a\u6c28\u57fa\u9178\u7684\u5168\u90e8\u5e8f\u5217)\u7684\u75ab\u82d7\u3002\u7ed3\u679c\u53d1\u73b0\u8d85\u8fc750%\u7684\u60a3\u8005\u75c5\u53d8\u5c40\u90e8\u6d88\u9000\u6216\u5b8c\u5168\u6d88\u9000\u3002<\/p>\n

\u6b64\u5916\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u75ab\u82d7\u8bf1\u5bfc\u7684T\u7ec6\u80de\u53cd\u5e94\u7684\u5f3a\u5ea6\u4e0e\u4e34\u5e8a\u53cd\u5e94\u4e4b\u95f4\u5b58\u5728\u9ad8\u5ea6\u663e\u8457\u7684\u76f8\u5173\u6027\u3002\u6211\u4eec\u5728VIN\u75c5\u4eba\u4e2d\u4e5f\u53d1\u73b0\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u7531\u6b64\u6211\u4eec\u53d1\u73b0\u7531\u75ab\u82d7\u8bf1\u5bfc\u7684T\u7ec6\u80de\u53cd\u5e94\u548c\u4e34\u5e8a\u53cd\u5e94\u4e4b\u95f4\u5b58\u5728\u5f3a\u70c8\u7684\u76f8\u5173\u6027\u3002\u4f46\u662f\u5728\u5bab\u9888\u764c\u60a3\u8005\u4e2d\uff0c\u540c\u6837\u7684\u75ab\u82d7\u5374\u4e0d\u5177\u6709\u514d\u75ab\u6027\uff0c\u5e76\u4e14\u5728\u5bab\u9888\u764c\u665a\u671f(\u590d\u53d1\u3001\u8f6c\u79fb)\u60a3\u8005\u4e2d\u65e0\u6cd5\u8868\u73b0\u51fa\u826f\u597d\u7684\u4e34\u5e8a\u6548\u679c\uff0c\u8fd9\u8868\u660e\u8fd9\u4e9b\u60a3\u8005\u7684\u514d\u75ab\u529f\u80fd\u53d7\u635f\uff0c\u9700\u8981\u989d\u5916\u7684\u8054\u5408\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14.9 \u6cbb\u7597\u6027SLP\u75ab\u82d7\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u7597\u6548\u9700\u8981\u501f\u52a9\u8054\u5408\u6cbb\u7597\u6765\u514b\u670d\u80bf\u7624\u5bf9T\u7ec6\u80de\u7684\u6291\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u679c\u6740\u4f24\u6027T\u7ec6\u80de\u4e0d\u80fd\u7acb\u5373\u5b8c\u5168\u6e05\u9664\u764c\u7ec6\u80de\uff0c\u53ef\u80fd\u5c31\u4f1a\u51fa\u73b0\u4e00\u79cd\u6162\u6027\u7684\u60c5\u51b5\uff0c\u5373\u7531\u4e8e\u6301\u7eed\u7684T\u7ec6\u80de\u53cd\u5e94\u4f1a\u5bfc\u81f4\u80bf\u7624\u5904\u4e8e\u6f5c\u4f0f\u671f\u3002Schreiber\u53ca\u5176\u540c\u4e8b\u5c06\u5176\u63cf\u8ff0\u4e3a\u80bf\u7624\u7ec6\u80de\u548c\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u5e73\u8861<\/span>\u3002\u6700\u7ec8\uff0c\u80bf\u7624\u53ef\u80fd\u901a\u8fc7\u5404\u79cd\u673a\u5236\u5b9e\u73b0\u514d\u75ab\u9003\u9038\u3002<\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6ca1\u6709\u51fa\u73b0\u5f3a\u5927\u7684\u6548\u5e94T\u7ec6\u80de\u548c\u8bb0\u5fc6T\u7ec6\u80de\u53cd\u5e94\u662f\u80bf\u7624\u5b9e\u73b0\u514d\u75ab\u9003\u9038\u6700\u5e38\u89c1\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u76f8\u53cd\uff0c\u5728\u5178\u578b\u6025\u6027\u75c5\u6bd2\u611f\u67d3\u4e2d\u5f80\u5f80\u4f1a\u6709\u5f3a\u70c8\u7684T\u7ec6\u80de\u53cd\u5e94\uff0c\u662f\u56e0\u4e3a\u6025\u6027\u75c5\u6bd2\u4f1a\u523a\u6fc0\u75c5\u6bd2\u7acb\u5373\u4ea7\u751f\u4e00\u7cfb\u5217\u4fe1\u53f7\uff0c\u8fd9\u4e9b\u4fe1\u53f7\u80fd\u5f3a\u70c8\u6fc0\u6d3b\u5148\u5929\u548c\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u8bb8\u591a\u7531\u81f4\u764c\u75c5\u6bd2\u5f15\u8d77\u7684\u764c\u75c7\u662f\u7531\u4e8e\u673a\u4f53\u957f\u671f(\u6216\u591a\u5e74)\u6301\u7eed\u611f\u67d3\u8be5\u764c\u75c7\u76f8\u5173\u7684\u75c5\u6bd2\uff08\u5982HPV\u6216HBV)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6162\u6027\u6301\u7eed\u6027\u75c5\u6bd2\u611f\u67d3\u4f1a\u901a\u8fc7\u8bb8\u591a\u514d\u75ab\u9003\u9038\u673a\u5236\u6765\u7834\u574f\u5148\u5929\u514d\u75ab\u548c\u83b7\u5f97\u6027\u514d\u75ab\uff0c\u4ee5\u5b9e\u73b0\u5176\u5728\u673a\u4f53\u5185\u7684\u6301\u7eed\u6027\u611f\u67d3\u3002<\/p>\n

\u6b64\u5916\uff0cT\u7ec6\u80de\u5bbf\u4e3b\u9632\u5fa1\u673a\u5236\u901a\u8fc7\u8c03\u8282T\u7ec6\u80de\u68c0\u67e5\u70b9\u6765\u907f\u514d\u8d85\u654f\u53cd\u5e94\uff0c\u4ece\u800c\u9002\u5e94\u6162\u6027\u6301\u7eed\u611f\u67d3\u3002\u5982\u679c\u8fd9\u79cd\u6301\u7eed\u611f\u67d3\u7684\u75c5\u6bd2\u78b0\u5de7\u5177\u6709\u81f4\u764c\u7279\u6027\uff0c\u8fd9\u5fc5\u7136\u4f1a\u9020\u6210\u6781\u5176\u53ef\u6015\u7684\u540e\u679c\u3002<\/p>\n

\u6301\u7eed\u7684T\u7ec6\u80de\u53cd\u5e94\u548c\u764c\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u901a\u5e38\u4f1a\u4f7f\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u51cf\u5f31\u673a\u4f53\u7684T\u7ec6\u80de\u53cd\u5e94\u800c\u5b9e\u73b0\u9003\u9038<\/span>\u3002\u4f8b\u5982\uff0c\u4ece\u6297\u539f\u7279\u5f02\u6027\u7684\u80bf\u7624\u6d78\u6da6\u6027T\u7ec6\u80de\u4e2d\u91ca\u653e\u7684\u5e72\u6270\u7d20\u03b3<\/span>\u53ef\u8bf1\u5bfc\u764c\u7ec6\u80de\u8868\u8fbePD-L1<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80bf\u7624\u7ec6\u80de\u5bf9\u5e72\u6270\u7d20\u03b3\u7684\u53cd\u5e94\u6027\u4e27\u5931\u662f\u6700\u5371\u9669\u7684T\u7ec6\u80de\u514d\u75ab\u9003\u9038\u673a\u5236\u4e4b\u4e00\uff0c\u5176\u8be6\u7ec6\u673a\u5236\u662f\u901a\u8fc7\u4e0b\u8c03\u03b22\u5fae\u7403\u86cb\u767d<\/strong>\u4f7f\u5f97\u764c\u7ec6\u80de\u7684HLAI<\/strong>\u7c7b\u8868\u8fbe\u5b8c\u5168\u4e27\u5931\uff0c\u03b22\u5fae\u7403\u86cb\u767d\u662f\u7ec6\u80de\u8868\u9762\u8868\u8fbeHLA I\u7c7b\u5206\u5b50\u7684\u5fc5\u8981\u5206\u5b50\u3002<\/p>\n

\u5e78\u8fd0\u5730\u662f\uff0c\u8fd9\u79cd\u60c5\u51b5\u6bd4\u8f83\u5c11\u89c1\u3002\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u8bb8\u591a\u9488\u5bf9\u514d\u75ab\u9003\u9038\u7684\u7597\u6cd5\u662f\u53ef\u884c\u7684\u3002\u4f8b\u5982\uff0cT\u7ec6\u80de\u56fa\u6709\u514d\u75ab\u529f\u80fd\u6291\u5236\u53ef\u80fd\u4e0d\u4ec5\u4ec5\u662f\u56e0\u4e3aPD-1\u4e0ePD-L1\u6291\u5236\uff0c\u8fd8\u53ef\u80fd\u662f\u5176\u4ed6\u673a\u5236,\u5982egr2\u9a71\u52a8\u7684\u8868\u8fbe\u4ee5\u53caLAG3\u548c4-1BB(CD137)\u7684\u6291\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u901a\u8fc7\u6291\u5236LAG3\u548c\u5e94\u7528\u9488\u5bf94-1BB\u7684\u6fc0\u52a8\u578b\u6297\u4f53\uff0c\u53ef\u4ee5\u63d0\u9ad8\u6740\u4f24\u6027T\u7ec6\u80de\u7684\u6d3b\u6027\u3002\u5018\u82e5\u6297\u539f\u5931\u53bb\u514d\u75ab\u539f\u6027\uff0c\u5b8c\u5168\u6297\u539f\u7b49\u7ea7\u4e2d\u7684\u7b2c\u4e8c\u6297\u539f\u53ef\u4ee5\u4ee3\u66ff\u5b8c\u5168\u6297\u539f\u7b49\u7ea7\u4e2d\u7684\u7b2c\u4e00\u6297\u539f\u6765\u523a\u6fc0T\u7ec6\u80de\u53cd\u5e94\uff0c\u7279\u522b\u662f\u5728\u63a5\u79cd\u6297\u539f\u75ab\u82d7\u6216\u963b\u65ad\u5176\u5bf9\u5e94\u7684PD-1\u68c0\u67e5\u70b9\u4e4b\u540e\u3002<\/p>\n

\u8fd9\u4e2a\u4f8b\u5b50\u8bf4\u660e\uff0c\u5728\u8bb8\u591a\u975e\u81ea\u4f53\u6392\u65a5\u7684\u514d\u75ab\u539f\u6027\u80bf\u7624\u4e2d\uff0c\u53ef\u80fd\u4e0d\u80fd\u591f\u81ea\u4e3b\u7684\u4ea7\u751f\u8db3\u591f\u7684T\u7ec6\u80de\u548c\u80bf\u7624\u76f8\u5173\u6297\u539f<\/span>\u3002\u540c\u6837\uff0c\u5c0f\u9f20\u4f53\u5185\u7684HPV16E6\/E7\u9633\u6027\u80bf\u7624\u4e0d\u4f1a\u81ea\u53d1\u4ea7\u751f\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\uff0c\u5373\u4f7f\u80bf\u7624\u8868\u8fbe\u4e86\u6297\u539f\uff0cTIL\u4e5f\u4e0d\u4f1a\u6e17\u900f\u548c\u6740\u4f24\u80bf\u7624\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7136\u800c\uff0c\u5c06\u987a\u94c2\u6216\u5361\u94c2\u548c\u7d2b\u6749\u9187\u7684\u5316\u7597<\/strong>\u4e0eHPV\u7279\u5f02\u6027SLP\u75ab\u82d7\u76f8\u7ed3\u5408<\/strong>\uff0c\u80fd\u591f\u4ea7\u751f\u80bf\u7624\u6d78\u6da6\u6027HPV\u7279\u5f02\u6027TIL\uff0c\u4ece\u800c\u5b8c\u5168\u6740\u4f24\u80bf\u7624\u3002<\/p>\n

\u8fd9\u79cd\u7c7b\u578b\u7684\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u7684\u4f5c\u7528\u673a\u5236\u6709\u5f88\u591a\u79cd\uff0c\u5305\u62ec\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u5bfc\u81f4DC\u7684\u6fc0\u6d3b\uff0c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\u534f\u540c\u6027\u7ec6\u80de\u51cb\u4ea1\uff0c\u75ab\u82d7\u8bf1\u5bfc\u7684TIL\u4e0e\u987a\u94c2\u7684\u8054\u5408\uff0c\u4ee5\u53ca\u8017\u5c3d\u8fc7\u591a\u514d\u75ab\u6291\u5236\u6027\u5355\u6838\u9ad3\u7cfb\u7ec6\u80de\u3002<\/p>\n

\u6b64\u5916\uff0c\u4e0e\u6cbb\u7597\u6027\u75ab\u82d7\u8054\u5408\u4f7f\u7528\u7684\u6cbb\u7597\u65b9\u6848\u8fd8\u6709\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242<\/span>\u7684\u8054\u5408\u6cbb\u7597\uff08\u7279\u522b\u662f\u6297PD-1\u68c0\u67e5\u70b9\u7597\u6cd5\u3002\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6cbb\u7597\u6027\u75ab\u82d7\u548c\u6297PD-1\u6291\u5236\u5242\u4e4b\u95f4\u7684\u534f\u540c\u4f5c\u7528\u5df2\u7ecf\u5728\u4e4b\u524d\u7684\u4e00\u4e9b\u4e34\u5e8a\u6a21\u578b\u4e2d\u63d0\u5230\u8fc7\u3002\u643a\u5e26\u9ed1\u8272\u7d20\u7624\u76f8\u5173\u6297\u539f\u7684DC\u75ab\u82d7\u53ef\u80fd\u4e0eCTLA-4\u963b\u6ede\u5242ipilimumab\u5728\u4ecb\u5bfc\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u53cd\u5e94\u65b9\u9762\u8d77\u534f\u540c\u4f5c\u7528\uff0c\u4f46\u8fd9\u4e00\u89c2\u5bdf\u7ed3\u679c\u4ecd\u9700\u8981\u5728\u968f\u673a\u7814\u7a76\u4e2d\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n

\u6b64\u5916\uff0c\u4e5f\u62a5\u9053\u8fc7\u6cbb\u7597\u6027\u75ab\u82d7\u4e0e\u6fc0\u52a8\u6027\u5355\u6297<\/span>\u4e4b\u95f4\u6709\u534f\u540c\u4f5c\u7528\uff1a\u6297CD27\u3001\u6297CD40\u3001\u6297CD134(\u6297OX40)\u6216\u6297CD-137(\u62974-1BB)\u3002<\/p>\n

\u6b64\u5916\uff0c\u9488\u5bf9\u7ec6\u80de\u56e0\u5b50IL-10\u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\u548cIL-6\u7684\u6291\u5236\u6027\u5355\u6297\u4e5f\u5df2\u88ab\u8054\u5408\u4f7f\u7528\u8fc7\u3002Fig. 14.2 <\/span>\u6982\u8ff0\u4e86\u76ee\u524d\u51e0\u79cd\u70ed\u95e8\u7684\u6cbb\u7597\u6027\u75ab\u82d7\u8054\u5408\u7597\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6700\u8fd1\uff0c\u6211\u4eec\u5728\u5bf9\u665a\u671f(\u590d\u53d1\u6216\u8f6c\u79fb\u6027)\u5bab\u9888\u764c\u60a3\u8005\u8fdb\u884c\u7684\u9884\u8bd5\u9a8c\u4e2d\u663e\u793a\uff0c\u5728Montanide\u4f50\u5242\u7684\u4f5c\u7528\u4e0b\uff0c\u63a5\u79cd\u4e0e\u5361\u94c2\u548c\u7d2b\u6749\u9187\u5316\u7597\u76f8\u7ed3\u5408\u7684SLP\u75ab\u82d7\uff0c\u5728HPV16\u4e2d\u53ef\u4ee5\u8bf1\u5bfc\u66f4\u5f3a\u70c8\u7684T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n

\u5176\u4e2d\u5316\u7597\u8d77\u5230\u4e86\u514d\u75ab\u8c03\u8282\u5242\u7684\u4f5c\u7528\uff0c\u867d\u7136T\u7ec6\u80de\u7684\u6570\u91cf\u548c\u529f\u80fd\u4e0d\u53d7\u8fd9\u79cd\u5316\u7597\u7ec4\u5408\u7684\u5f71\u54cd\uff0c\u4f46\u5728\u6240\u6709\u60a3\u8005\u4e2d\u53ef\u4ee5\u89c2\u5bdf\u5230\u6291\u5236\u6027\u5355\u6838\u9ad3\u7cfb\u7ec6\u80de<\/span>\u7684\u6c34\u5e73\u5728\u7b2c\u4e8c\u4e2a\u5316\u7597\u5468\u671f\u7684\u7b2c\u4e8c\u4e2a\u661f\u671f\u4e0b\u964d\u5230\u5065\u5eb7\u6c34\u5e73\u3002\u5728\u8be5\u65f6\u95f4\u70b9\u7ed9\u4e88\u5355\u5242\u75ab\u82d7\u540e\uff0c\u53ef\u5bfc\u81f4HPV16 E6\/E7\u7684T\u7ec6\u80de\u5e94\u7b54\u6bd4\u6ca1\u6709\u5b9a\u65f6\u5316\u7597\u7684\u524d\u4e00\u6b21\u8bd5\u9a8c\u89c4\u6a21\u66f4\u5927\uff0c\u53cd\u5e94\u66f4\u5f3a\u70c8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u57fa\u4e8e\u8fd9\u4e9b\u89c2\u5bdf\uff0c\u6211\u4eec\u73b0\u5728\u5df2\u7ecf\u7ed3\u675f\u4e86\u5bf970\u540d\u665a\u671f(\u590d\u53d1\u6216\u8f6c\u79fb)HPV16+\u5bab\u9888\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u8fd9\u9879\u8bd5\u9a8c\u4e2d\uff0cHPV16  SLP\u75ab\u82d7\u7684\u4e09\u5242\u75ab\u82d7\u4e2d\u7684\u7b2c\u4e00\u5242ISA101\uff0c\u5728PBMC\u4e2d\u5355\u6838\u9ad3\u7cfb\u7ec6\u80de\u8ba1\u6570\u7684\u6700\u5c0f\u503c(\u5373\u7b2c\u4e8c\u4e2a\u5316\u7597\u5468\u671f\u540e2\u5468)\u518d\u6b21\u63a5\u79cd\uff0c\u968f\u540e\u53ef\u4ee5\u89c2\u5bdf\u5230\u75ab\u82d7\u8bf1\u5bfc\u7684HPV16\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u5f3a\u5ea6\u4e0e\u60a3\u8005\u7684\u603b\u4f53\u751f\u5b58\u4e4b\u95f4\u5b58\u5728\u9ad8\u5ea6\u663e\u8457\u7684\u76f8\u5173\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
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<\/p>\n<\/section>\n<\/section>\n

\n
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Fig. 14.2 <\/span>\u75ab\u82d7\u4e0e\u514d\u75ab\u8c03\u8282\u5242\u534f\u540c\u4f5c\u7528\uff0c\u662f\u4e00\u79cd\u6709\u6548\u6cbb\u7597\u764c\u75c7\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n

(a)\u764c\u75c7\u5fae\u73af\u5883\u4e2d\u6291\u5236T\u7ec6\u80de\u53cd\u5e94\u7684\u7ec6\u80de\u5305\u62ec\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de(TAM)\u3001\u9aa8\u9ad3\u6765\u6e90\u7684\u6291\u5236\u6027\u7ec6\u80de(MDSC)\u548c\u4ea7\u751fIL-10\u7684\u7c92\u7ec6\u80de<\/span>\u3002\u6b64\u5916\uff0c\u5728\u8fd9\u79cd\u73af\u5883\u4e2d\u4f1a\u91ca\u653e\u4e00\u4e9b\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u3002\u5e76\u4e14\u4e00\u6c27\u5316\u6c2e\u548cIDO\u9176\u53ef\u80fd\u4f1a\u8fdb\u4e00\u6b65\u52a0\u5267\u514d\u75ab\u6291\u5236\u3002<\/p>\n

(b)\u4e0e\u4f7f\u7528\u514d\u75ab\u8c03\u8282\u5242\u7684\u5355\u4e00\u7597\u6cd5\u76f8\u6bd4\uff0c\u75ab\u82d7\u6fc0\u6d3b\u4e86\u66f4\u591a\u7684\u7279\u5f02\u6027\u6740\u4f24T\u7ec6\u80de\uff0c\u589e\u52a0\u4e86\u6cbb\u7597\u6210\u529f\u7684\u673a\u4f1a\u3002<\/p>\n

(c)SLP\u75ab\u82d7\u53ef\u5c06\u201c\u51b7\u201d\u80bf\u7624\u5fae\u73af\u5883(\u65e0T\u7ec6\u80de\u6d78\u6da6\u6027)\u8f6c\u53d8\u4e3a\u201c\u70ed\u201d\u80bf\u7624\u5fae\u73af\u5883(T\u7ec6\u80de\u6d78\u6da6\u6027)\u3002\u514d\u75ab\u8c03\u8282\u5242\u53ef\u4ee5\u6839\u636e\u6bcf\u4e2a\u764c\u75c7\u60a3\u8005\u7684\u9700\u8981\uff0c\u4ee5\u591a\u79cd\u65b9\u5f0f\u6d88\u9664\u514d\u75ab\u6291\u5236\u7684\u80bf\u7624\u5fae\u73af\u5883\u3002\u56e0\u6b64\uff0c\u5c06\u75ab\u82d7\u548c\u514d\u75ab\u8c03\u8282\u5242\u534f\u540c\u4f5c\u7528\uff0c\u53ef\u4ee5\u5b9e\u73b0\u6709\u6548\u7684\u764c\u75c7\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/p>\n<\/section>\n<\/section>\n

\n
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14.10 \u524d\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u76f4\u5230\u6700\u8fd1\uff0c\u624d\u53d1\u73b0\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u7684\u764c\u75c7\u75ab\u82d7\u6709\u6cbb\u7597\u764c\u524d\u75be\u75c5\u7684\u4e34\u5e8a\u7597\u6548\u3002\u5982\u679c\u9009\u62e9\u6b63\u786e\u7684\u80bf\u7624\u9776\u6297\u539f\uff0c\u5e76\u7ed3\u5408\u6709\u6548\u7684\u75ab\u82d7\u5e73\u53f0\u548c\u9002\u5f53\u7684\u4f50\u5242\uff0c\u4ee5\u53ca\u5404\u79cd\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6216\u6fc0\u52a8\u6027\u5355\u6297\u8054\u5408\u6cbb\u7597\uff0c\u5176\u7597\u6548\u662f\u975e\u5e38\u597d\u7684\u3002<\/p>\n

\u6700\u597d\u7684\u9776\u6297\u539f\u663e\u7136\u662f\u5728\u764c\u75c7\u4e2d\u7531\u75c5\u6bd2\u8bf1\u5bfc\u7684\u75c5\u6bd2\u6297\u539f\u6216\u7531\u8bf1\u53d8\u5242\u8bf1\u5bfc\u7684\u65b0\u6297\u539f\u3002\u4e5f\u53ef\u4ee5\u9009\u62e9\u8fc7\u8868\u8fbe\u6216\u5206\u5316\u7684\u6297\u539f\uff0c\u524d\u63d0\u662fCD4+<\/sup>\u548cCD8+<\/sup>T\u7ec6\u80de\u6709\u660e\u663e\u7684\u9488\u5bf9\u6240\u9009\u6297\u539f\u7684\u8c31\u7cfb\u3002<\/p>\n

\u764c\u75c7\u6cbb\u7597\u6027\u75ab\u82d7\u53ef\u4ee5\u5f88\u597d\u5730\u6cbb\u7597\u56e0T\u7ec6\u80de\u53cd\u5e94\u5f31\u800c\u5bfc\u81f4\u201c\u51b7\u201d\u80bf\u7624\u5fae\u73af\u5883<\/span>\u7684\u60a3\u8005\u3002\u8bb8\u591a\u60a3\u8005\u5728\u63a5\u79cd\u6cbb\u7597\u6027\u75ab\u82d7\u540e\uff0c\u5145\u8db3\u5242\u91cf\u7684\u75ab\u82d7\u53ef\u80fd\u4f1a\u8bf1\u5bfc\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u6e17\u900f\u5230\u80bf\u7624\u4e2d\uff0c\u5e76\u5c06\u5176\u80bf\u7624\u5fae\u73af\u5883\u8f6c\u53d8\u4e3a\u201c\u70ed\u201d\u80bf\u7624\u5fae\u73af\u5883<\/span>\u3002<\/p>\n

\u867d\u7136\u5355\u9760\u6cbb\u7597\u6027\u75ab\u82d7\u4e0d\u592a\u53ef\u80fd\u8d77\u5230\u5341\u5206\u6709\u6548\u7684\u4e34\u5e8a\u53cd\u5e94\uff0c\u4f46\u5982\u679c\u628a\u5b83\u4e0e\u5176\u4ed6\u6297\u764c\u836f\u7269\u4e00\u8d77\u8054\u5408\u6cbb\u7597<\/strong>\u53ef\u80fd\u4f1a\u53d6\u5f97\u4e0d\u9519\u7684\u7597\u6548\u3002\u8fd9\u4e9b\u8054\u5408\u7684\u6297\u764c\u836f\u7269\u526f\u4f5c\u7528\u4e5f\u76f8\u5bf9\u8f83\u5c11\uff0c\u8054\u5408\u4f7f\u7528\u66f4\u80fd\u589e\u52a0\u5176\u7597\u6548\u3002<\/p>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 |<\/span>Oncoimmunology: A Practical Guide <\/span><\/section>\n
f<\/span>or Cancer Immunotherapy<\/span><\/section>\n
<\/span><\/section>\n
\u4f5c\u8005 | Cornelis J.M. Melief<\/span><\/span><\/section>\n
\u7ffb\u8bd1 | \u90d1\u68a6\u6021 \u7ae0\u9707 \u7f57\u4f73\u4f73<\/span><\/section>\n
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\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

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