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16.1      NK\u7ec6\u80de\u5728\u6cbb\u7597\u4e2d\u7684\u5e94\u7528<\/strong>
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\u8fd9\u4e00\u7b56\u7565\u5305\u62ec\u5728\u5065\u5eb7\u4f9b\u4f53\u4e2d\u7eaf\u5316NK\u7ec6\u80de\uff0c\u5e76\u5728\u5c06\u5b83\u4eec\u6ce8\u5c04\u5230\u60a3\u8005\u4f53\u5185\u4e4b\u524d\u7528\u514d\u75ab\u523a\u6fc0\u6027\u7ec6\u80de\u56e0\u5b50\uff08IL-2\u6216IL-15\uff09\u8fdb\u884c\u57f9\u517b\uff08Fig.16.1a<\/span>\uff09\u3002\u5df2\u8bc1\u660e\u8fd9\u79cd\u65b9\u6cd5\u662f\u6709\u6548\u548c\u5b89\u5168\u7684\uff0c\u4f46\u5176\u9650\u5236\u56e0\u7d20\u4ecd\u7136\u662f\u8f93\u6ce8\u7684NK\u7ec6\u80de\u5728\u60a3\u8005\u4f53\u5185\u6301\u7eed\u548c\u589e\u6b96\u7684\u80fd\u529b\u4e0d\u8db3\u3002\u9274\u4e8e\u5982\u4eca\u5bf9ILC\u590d\u6742\u6027\u7684\u4e86\u89e3\uff0c\u5728\u672a\u6765\uff0c\u8fd8\u53ef\u80fd\u8bbe\u8ba1\u9488\u5bf9\u4e0d\u540cILC\u4e9a\u7fa4\u7684\u65b0\u6cbb\u7597\u7b56\u7565\u3002\u4f8b\u5982\uff0c\u5728\u56e0\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u800c\u63a5\u53d7\u9020\u8840\u7ec6\u80de\u79fb\u690d\u7684\u60a3\u8005\u4e2d\uff0c\u6709\u8bc1\u636e\u8868\u660e\u8868\u8fbe\u6d3b\u5316NK\u7ec6\u80de\u53d7\u4f53\u7684ILC\uff0c\u53ef\u80fd\u901a\u8fc7\u5176\u589e\u5f3a\u7ec4\u7ec7\u4fee\u590d\u7684\u80fd\u529b\u6765\u5bf9\u6025\u6027\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u8d77\u5230\u4fdd\u62a4\u4f5c\u7528\u3002\u8fd9\u4e9b\u6570\u636e\u9700\u8981\u8fdb\u4e00\u6b65\u8bc1\u5b9e\uff0c\u4f46\u5b83\u4eec\u53ef\u80fd\u4e3aILC\u8f93\u6ce8\u6216\u5229\u7528\u53c2\u4e0e\u7c98\u819c\u6108\u5408\u7684ILC\u884d\u751f\u5206\u5b50\uff08\u5982IL-22\uff09\u8fdb\u884c\u7ed9\u836f\u6cbb\u7597\u5f00\u8f9f\u4e86\u9053\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 16.1a   <\/span>NK\u7ec6\u80de\u4ece\u5065\u5eb7\u6350\u8d60\u8005\u7684\u5916\u5468\u8840\u4e2d\u7eaf\u5316\u51fa\u6765\uff0c\u5e76\u5728\u6ce8\u5c04\u5230\u60a3\u8005\u4f53\u5185\u4e4b\u524d\u5728\u4f53\u5916\u7528\u7ec6\u80de\u56e0\u5b50\uff08IL-2\u6216IL-15\uff09\u6fc0\u6d3b\u3002\u5f53\u4f9b\u4f53\u4e0d\u8868\u8fbe\u8bc6\u522b\u60a3\u8005HLA\u5206\u5b50\u7684KIR\u65f6\uff0c\u53ef\u4ee5\u4f7f\u8f93\u6ce8\u7684NK\u7ec6\u80de\u4e0d\u63a5\u6536\u764c\u7ec6\u80de\u7684\u6291\u5236\u4fe1\u53f7\uff0c\u53ef\u83b7\u5f97\u6700\u4f73\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4fee\u9970NK\u7ec6\u80de\u57fa\u56e0\u63d0\u9ad8\u8fc7\u7ee7\u6027\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c<\/p>\n<\/section>\n

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\u76ee\u524d\u5df2\u5f00\u53d1\u51fa\u589e\u5f3aNK\u7ec6\u80de\u6297\u80bf\u7624\u529f\u80fd\u7684\u65b0\u57fa\u56e0\u6cbb\u7597\u65b9\u6cd5\uff0c\u5e76\u6b63\u5728\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u7814\u7a76\u3002\u5982\u65e8\u5728\u5229\u7528\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CARs\uff09\u589e\u5f3aNK\u7ec6\u80de\u80bf\u7624\u7279\u5f02\u6027\u7684\u65b9\u6cd5\uff08Fig.16.1b<\/span>\uff09\uff0c\u6b63\u5728\u901a\u8fc7\u5404\u79cd\u4e34\u5e8a\u524d\u7814\u7a76\u4ee5\u63a2\u7d22\u8868\u8fbeCD19\u6216CD20\u53d7\u4f53\u7279\u5f02\u6027\u7684CAR-NK\u7ec6\u80de\u5728B\u7ec6\u80de\u75c5\u7406\u4e2d\u7684\u5e94\u7528\u3002\u6216\u8005\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u9006\u8f6c\u5f55\u75c5\u6bd2\u8f6c\u5bfcNK\u7ec6\u80de\u4ee5\u8868\u8fbeNKG2D\u6216TRAIL\u663e\u793a\u5176\u80bf\u7624\u8bc6\u522b\u548c\u6740\u4f24\u7684\u80fd\u529b\u5f97\u5230\u6539\u5584\u3002\u53e6\u4e00\u79cd\u7b56\u7565\u662f\u4f7f\u7528TGF-27\u7684\u663e\u6027\u8d1f\u6027\u53d7\u4f53II\u4fdd\u62a4NK\u7ec6\u80de\u514d\u53d7\u80bf\u7624\u5fae\u73af\u5883\u4e2dTGF-\u03b2\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u6216\u901a\u8fc7\u5f3a\u5236\u8868\u8fbeIL-2\u6216IL-15\u6765\u63d0\u9ad8NK\u7ec6\u80de\u5728\u4f53\u5185\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 16.1b <\/span>  NK\u7ec6\u80de\u662f\u4ece\u60a3\u8005\u7684\u5916\u5468\u8840\u4e2d\u7eaf\u5316\u51fa\u6765\u7684\uff0c\u5e76\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\uff0c\u4ee5\u8868\u8fbe\u4e00\u79cd\u9488\u5bf9\u80bf\u7624\u6297\u539f\uff08CAR\uff09\u6216\u5176\u4ed6\u80fd\u591f\u66f4\u6709\u6548\u5730\u5c06NK\u7ec6\u80de\u5bfc\u5411\u5176\u76ee\u6807\u7684\u5206\u5b50\u7684\u5d4c\u5408\u53d7\u4f53\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684\u76f8\u5173\u4e34\u5e8a\u7814\u7a76\uff0c\u5305\u62ec\u6d4b\u8bd5\u7ec6\u80de\u56e0\u5b50\uff08\u5982IL-2\u3001IL-15\u548cIL-12\uff09\u5728\u51e0\u79cd\u764c\u75c7\u4e2d\u7684\u6709\u6548\u6027\u548c\u526f\u4f5c\u7528\uff08Fig.16.1c<\/span>\uff09\u3002\u5728Rosenberg\u7b49\u4eba\u7684\u4e00\u9879\u65e9\u671f\u7814\u7a76\u4e2d\uff0c\u6dcb\u5df4\u56e0\u5b50\u6fc0\u6d3b\u7684\u6740\u4f24\u7ec6\u80de\uff08LAK\u7ec6\u80de\uff09\u548cIL-2\u7684\u7ed3\u5408\u5bfc\u81f4\u9ed1\u8272\u7d20\u7624\u6216\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u5e94\u7b54\u7387\u4e3a20%\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u7684\u4e3b\u8981\u95ee\u9898\u662f\uff1a\u514d\u75ab\u7cfb\u7edf\u4ee5\u975e\u7279\u6b8a\u7684\u65b9\u5f0f\u8fc7\u5ea6\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u795e\u7ecf\u75c5\u53d8\u3001\u6bdb\u7ec6\u8840\u7ba1\u6e17\u6f0f\u7efc\u5408\u5f81\u548c\u80be\u529f\u80fd\u8870\u7aed\uff0c\u8fdb\u800c\u5bfc\u81f4\u7ec6\u80de\u6bd2\u6027\u3002IL-15\u662fIL-2\u7684\u4e00\u4e2a\u91cd\u8981\u7684\u66ff\u4ee3\u54c1\uff0c\u4e14\u5df2\u7ecf\u5728\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u548c\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 16.1c<\/span>    \u5411\u60a3\u8005\u65bd\u7528\u514d\u75ab\u523a\u6fc0\u6027\u7ec6\u80de\u56e0\u5b50\u4ee5\u8bf1\u5bfc\u81ea\u4f53NK\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u6269\u589e\u3002\u8bf1\u5bfc\u6700\u5f3a\u6297\u80bf\u7624\u53cd\u5e94\u7684\u7ec6\u80de\u56e0\u5b50\u662fIL-2\uff0c\u4f46\u4e5f\u4f1a\u5f15\u8d77\u663e\u8457\u7684\u526f\u4f5c\u7528\uff0c\u4f8b\u5982\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u6269\u5f20\u548c\u7ec4\u7ec7\u5185\u6d78\u6da6\uff0c\u8fd9\u4f7f\u5f97\u5176\u96be\u4ee5\u4f7f\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027\u6297\u4f53\u7684\u8f93\u6ce8\u8bf1\u5bfcADCC<\/p>\n<\/section>\n

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\u8bb8\u591a\u4e34\u5e8a\u6279\u51c6\u7684\u9488\u5bf9\u80bf\u7624\u76f8\u5173\u6297\u539f\u7684\u6cbb\u7597\u6027\u6297\u4f53\uff08\u5982\u5229\u59a5\u6614\u5355\u6297\u6216\u897f\u59a5\u6614\u5355\u6297\uff09\u901a\u8fc7\u6fc0\u6d3bNK\u7ec6\u80de\u4ecb\u5bfc\u7684ADCC \u53d1\u6325\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08Fig.16.2a<\/span>\uff09\u3002\u4e3a\u4e86\u63d0\u9ad8IgG Fc\u533a\u6fc0\u6d3b\u53d7\u4f53Fc RIIIA\u7684\u4eb2\u548c\u529b\uff0c\u4eba\u4eec\u5c1d\u8bd5\u4e86\u8bb8\u591a\u4e0d\u540c\u7684\u65b9\u6cd5\uff0c\u5305\u62ec\u63d2\u5165\u7a81\u53d8\u6216\u7cd6\u57fa\u5316\u3002\u5982\u8fd1\u671f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597T\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u83ab\u52a0\u6728\u73e0\u5355\u6297\uff08\u4e00\u79cd\u4f4e\u5ca9\u85fb\u7cd6\u6297CCR4\u5355\u6297\uff09\u548c\u5965\u6bd4\u59a5\u73e0\u5355\u6297\uff08\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u7684\u6297CD20\u5355\u6297\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8f93\u6ce8\u9488\u5bf9\u6291\u5236\u6027NK\u7ec6\u80de\u53d7\u4f53\u7684\u6297\u4f53<\/p>\n<\/section>\n

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\u8fd9\u79cd\u65b9\u6cd5\u7684\u76ee\u7684\u662f\uff0c\u901a\u8fc7\u5355\u514b\u9686\u6297\u4f53\u963b\u65ad\u6291\u5236\u6027NK\u7ec6\u80de\u53d7\u4f53\u6765\u63d0\u9ad8\u81ea\u4f53NK\u7ec6\u80de\u7684\u53cd\u5e94\u6027\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u60a3\u8005\u7684\u76ee\u6807\uff08Fig.16.2b<\/span>\uff09\u3002\u5bf9\u4e8e\u672a\u4fee\u9970\u7684\u5355\u514b\u9686\u6297\u4f53\uff08\u5982\u5229\u59a5\u6614\u5355\u6297\uff09\uff0cNK\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4ecd\u53d7\u6291\u5236\u6027\u53d7\u4f53\u7684\u63a7\u5236\u3002\u901a\u8fc7\u4f7f\u7528\u963b\u65ad\u67d0\u4e9b\u6291\u5236\u6027\u53d7\u4f53\u4e0e\u5176\u914d\u4f53\u76f8\u4e92\u4f5c\u7528\u7684\u6297\u4f53\uff0c\u6709\u53ef\u80fd\u589e\u5f3a\u4f53\u5185\u6297\u80bf\u7624NK\u7ec6\u80de\u7684\u53cd\u5e94\u3002\u867d\u7136NK\u7ec6\u80de\u6ca1\u6709\u771f\u6b63\u7279\u5f02\u7684\u5206\u5b50\uff0c\u4f46\u6709\u4e00\u4e9b\u8868\u9762\u53d7\u4f53\u4e3b\u8981\u7531NK\u7ec6\u80de\u8868\u8fbe\uff0c\u5e76\u5728\u8c03\u8282\u5176\u529f\u80fd\u4e2d\u53d1\u6325\u4e3b\u8981\u4f5c\u7528\u3002\u8fd9\u4e9b\u5206\u5b50\u6fc0\u6d3b\u8d1f\u4fe1\u53f7\u901a\u8def\uff0c\u5e76\u5728\u63a7\u5236\u7ec6\u80de\u6bd2\u6027\u4e2d\u4f5c\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u53d1\u6325\u4f5c\u7528\u3002\u5728\u4e0b\u4e00\u6bb5\u4e2d\uff0c\u6211\u4eec\u5c06\u91cd\u70b9\u5173\u6ce8\u8fd9\u79cd\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 16.2<\/span>  \u8f93\u6ce8NK\u7ec6\u80de\u7279\u5f02\u6027\u5355\u514b\u9686\u6297\u4f53\u3002\uff08a\uff09\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684\u5355\u514b\u9686\u6297\u4f53\u4e5f\u53ef\u4ee5\u4e0eNK\u7ec6\u80de\u8868\u8fbe\u7684Fc RIIIA\u53d7\u4f53\u7ed3\u5408\uff0c\u5e76\u8bf1\u5bfcNK\u4ecb\u5bfc\u7684ADCC\u3002\uff08b\uff09\u8f93\u6ce8\u9488\u5bf9\u6291\u5236\u6027NK\u7ec6\u80de\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\u53ef\u963b\u65ad\u4e0e\u914d\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4f7fNK\u7ec6\u80de\u6709\u6548\u6740\u6b7b\u9776\u7ec6\u80de<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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16.2 <\/strong>\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u51e0\u5341\u5e74\u6765\uff0c\u514d\u75ab\u7cfb\u7edf\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u4e00\u76f4\u6ca1\u6709\u5f97\u5230\u91cd\u89c6\uff0c\u5728\u4e00\u822c\u60c5\u51b5\u4e0b\uff0c\u80bf\u7624\u901a\u8fc7\u6fc0\u6d3b\u8c03\u8282\u514d\u75ab\u7a33\u6001\u7684\u9014\u5f84\uff0c\u6709\u6548\u5730\u6291\u5236\u4e86\u514d\u75ab\u53cd\u5e94\u3002\u5df2\u8bc1\u660e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(ICI)\uff08\u5982\u963b\u65ad\u6297\u4f53\uff09\u662f\u6709\u6548\u7684\uff0c\u5bf9\u51e0\u79cd\u764c\u75c7\u7c7b\u578b\u5177\u6709\u53ef\u63a7\u5236\u7684\u5b89\u5168\u6027(Fig.16.3<\/span>)\u3002\u5b83\u4eec\u7684\u4f7f\u7528\u4f7f\u4e00\u4e9b\u764c\u75c7\u60a3\u8005\uff08\u5982\u8f6c\u79fb\u6027\u9ed1\u7d20\u7624\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff09\u7684\u6cbb\u7597\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u5e76\u83b7\u5f97\u4e86\u8d85\u8fc710\u5e74\u7684\u957f\u671f\u751f\u5b58\u671f\u3002\u56e0\u6b64\uff0c\u514d\u75ab\u53cd\u5e94\u6291\u5236\u9014\u5f84\u7684\u53d1\u73b0\u662f\u4e00\u4e2a\u5f00\u521b\u6027\u7684\u53d1\u73b0\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u6211\u4eec\u5bf9\u514d\u75ab\u7684\u7406\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 16.3<\/span>  NK\/\u9776\u7ec6\u80de\u8868\u9762\u53d7\u4f53\/\u914d\u4f53\u6291\u5236\u76f8\u4e92\u4f5c\u7528\u3002\u51e0\u79cd\u6291\u5236\u6027\u53d7\u4f53\u548c\u5171\u53d7\u4f53\u534f\u540c\u8c03\u8282NK\u7ec6\u80de\u529f\u80fd\u3002\u4e0e\u57fa\u4e8e\u60a3\u8005\u548c\u80bf\u7624\u7279\u5f02\u6027\u7279\u5f81\u5f00\u53d1\u7684\u963b\u65ad\u6027\u5355\u514b\u9686\u6297\u4f53\u7684\u8054\u5408\u4f7f\u7528\u53ef\u4ee5\u89e3\u653e\u9488\u5bf9NK\u7ec6\u80de\u6d3b\u5316\u7684\u963b\u65ad\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5927\u591a\u6570\u6291\u5236\u6027\u53d7\u4f53\u5728\u5176\u7ec6\u80de\u8d28\u7ed3\u6784\u57df\u4e2d\u542b\u6709\u4e00\u4e2a\u6216\u591a\u4e2a\u78f7\u9178\u5316\u7684ITIM\uff0c\u5e76\u53ef\u62db\u52df\u86cb\u767d\u916a\u6c28\u9178\u78f7\u9178\u9176\uff08SHP-1\/2\u6216SHIP\uff09\u3002\u4e00\u9879\u6a2a\u8de8\u6574\u4e2a\u57fa\u56e0\u7ec4\u7684\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u63ed\u793a\u4e86300\u591a\u79cd\u81f3\u5c11\u5305\u542b\u4e00\u4e2aITIM\u57df\u7684I\u578b\u548cII\u578b\u6574\u5408\u819c\u86cb\u767d\u7684\u5b58\u5728\u3002\u4f46\u662f\u5728\u8fd9\u4e9b\u53d7\u4f53\u4e2d\uff0c\u53ea\u6709\u5c11\u6570\u662f\u6cbb\u7597\u65b9\u6cd5\u51fa\u73b0\u8fc7\u7684\u9776\u5411\u53d7\u4f53\uff08Table 16.1<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 16.1<\/span>  \u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684NK\u7ec6\u80de\u53d7\u4f53\/\u914d\u4f53\u9776\u5411\u836f\u7269<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/span><\/p>\n


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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 |<\/span>Oncoimmunology: A Practical Guide <\/span><\/section>\n
f<\/span>or Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 |  <\/span>Laura Chiossone and Eric Vivier<\/span><\/span><\/section>\n
\u7ffb\u8bd1 |  \u90ed\u5b50 \u848b\u4fca\u535a \u7f57\u4f73\u4f73<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u6e29\u946b<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u4efb\u632f\u9633 \u5ed6\u5a9b<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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