{"id":4775,"date":"2023-01-17T13:00:30","date_gmt":"2023-01-17T05:00:30","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/01\/17\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac17%e7%ab%a0%ef%bc%9aido-tdo%e7%9a%84%e6%8a%91%e5%88%b6%e5%9c%a8%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8%ef%bc%88\/"},"modified":"2023-01-17T13:00:30","modified_gmt":"2023-01-17T05:00:30","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac17%e7%ab%a0%ef%bc%9aido-tdo%e7%9a%84%e6%8a%91%e5%88%b6%e5%9c%a8%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8%ef%bc%88","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/01\/17\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac17%e7%ab%a0%ef%bc%9aido-tdo%e7%9a%84%e6%8a%91%e5%88%b6%e5%9c%a8%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8%ef%bc%88\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c17\u7ae0\uff1aIDO\/TDO\u7684\u6291\u5236\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\uff08\u4e0a\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c16\u7ae0 \u57fa\u4e8eNK\u7ec6\u80de\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\uff08\u4e0b\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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17.1 \u4ecb\u7ecd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u957f\u671f\u4ee5\u6765\uff0c\u7531 TDO2 \u57fa\u56e0\u7f16\u7801\u7684 TDO \u88ab\u8ba4\u4e3a\u662f\u8c03\u8282\u81b3\u98df\u4e2d\u8272\u6c28\u9178\u5206\u89e3\u4ee3\u8c22\u7684\u4e3b\u8981\u809d\u9176\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0cIDO\u662f\u4e00\u79cd\u66f4\u5e7f\u6cdb\u8868\u8fbe\u7684\u8bf1\u5bfc\u578b\u9176\u300220\u4e16\u7eaa60\u5e74\u4ee3\uff0c\u7f16\u7801IDO\u7684IDO1\u57fa\u56e0\u4f5c\u4e3a\u7b2c\u4e00\u4e2a\u5e72\u6270\u7d20\u6fc0\u6d3b\u57fa\u56e0\u88ab\u53d1\u73b0\u3002\u5c3d\u7ba1\u5728\u4f20\u67d3\u75c5\u9886\u57df\u4e5f\u8fdb\u884c\u4e86\u4e00\u4e9b\u76f8\u5173\u7684\u7814\u7a76\uff0c\u4f46\u8fd9\u79cd\u8054\u7cfb\u5728\u5f53\u65f6\u5e76\u672a\u5f97\u5230\u8db3\u591f\u7684\u91cd\u89c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1998\u5e74\uff0c\u5728Munn\u3001Mellor\u548c\u4ed6\u4eec\u540c\u4e8b\u7684\u5f00\u521b\u6027\u5de5\u4f5c\u4e2d\uff0c\u4ed6\u4eec\u5c06IDO\u4e0e\u598a\u5a20\u671f\u95f4T \u7ec6\u80de\u5b9a\u5411\u514d\u75ab\u6291\u5236\u8054\u7cfb\u8d77\u6765\uff0c\u8fd9\u662f\u5173\u4e8e\u8272\u6c28\u9178\u5206\u89e3\u4ee3\u8c22\u7684\u751f\u7406\u610f\u4e49\u7684\u5173\u952e\u6982\u5ff5\u6027\u7a81\u7834\u3002<\/p>\n

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Fig. 17.1<\/span>  IDO\/TDO\u5728\u80bf\u7624\u4e2d\u7684\u8868\u8fbe\u548c\u4f5c\u7528\u90e8\u4f4d\u3002IDO1\u3001IDO2\u548c TDO\u5728\u80bf\u7624\u5fae\u73af\u5883(\u5305\u62ec\u8f6c\u79fb\u90e8\u4f4d)\u548c\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3(TDLN)\u7684\u5404\u79cd\u7ec6\u80de\u4e2d\u90fd\u6709\u8868\u8fbe\uff0c\u5305\u62ec\u5728\u80bf\u7624\u3001\u95f4\u8d28\u3001\u8840\u7ba1\u548c\u514d\u75ab\u7ec6\u80de\u4e2d\u3002\u7531IDO1\u548cTDO\u4ecb\u5bfc\u7684\u8272\u6c28\u9178\u5265\u593a\u548c\u72ac\u5c3f\u6c28\u9178\u7684\u4ea7\u751f\u90fd\u4e0e\u708e\u75c7\u8fc7\u7a0b\u548c\u514d\u75ab\u9003\u9038(\u6297\u539f\u8010\u53d7)\u6709\u5173\u3002\u4e0a\u56fe\u8fd8\u5c55\u793a\u4e86IDO\/TDO\u6d3b\u6027\u5bf9T\u7ec6\u80de\u548cMDSC\u529f\u80fd\u7684\u5f71\u54cd\u3002APC\uff0c\u6297\u539f\u63d0\u5448\u7ec6\u80de(\u5982\u6811\u7a81\u72b6\u7ec6\u80de)\uff1bMDSC\uff0c\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff1bTAM\uff0c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff1bTAN\uff0c\u80bf\u7624\u76f8\u5173\u4e2d\u6027\u7c92\u7ec6\u80de\uff1bTeff\uff0c\u6548\u5e94T\u7ec6\u80de\uff1bTreg\uff0c<\/span>\u8c03\u8282\u6027T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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17.2 IDO1\u5728T\u7ec6\u80de\u514d\u75ab\u9003\u9038\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u764c\u75c7\u751f\u7269\u5b66\u5bb6\u666e\u904d\u8ba4\u4e3a\u80bf\u7624\u7ec6\u80de\u7684\u56fa\u6709\u7279\u5f81\u5177\u6709\u51b3\u5b9a\u6027\u7684\u91cd\u8981\u610f\u4e49\uff0c\u8fd9\u4e00\u89c2\u70b9\u88ab\u6982\u62ec\u5728\u4e00\u4e2a\u6781\u5177\u5f71\u54cd\u529b\u7684\u764c\u75c7\u7279\u5f81\u5206\u7c7b\u4e2d\u3002<\/p>\n

\u5728\u8fd9\u4e2a\u666e\u904d\u7684\u6982\u5ff5\u4e2d\uff0c\u8f6c\u79fb\u548c\u8840\u7ba1\u751f\u6210\u8fd9\u4e24\u4e2a\u516c\u8ba4\u7684\u660e\u663e\u4f9d\u8d56\u5bbf\u4e3b\u7684\u7279\u5f81\u662f\u4ece\u4ee5\u80bf\u7624\u4e3a\u4e2d\u5fc3\u7684\u89d2\u5ea6\u6765\u8003\u8651\u7684\uff0c\u800c\u6ca1\u6709\u8003\u8651\u5230\u80bf\u7624\u4e0e\u5bbf\u4e3b\u514d\u75ab\u7684\u76f8\u4e92\u4f5c\u7528\u4e5f\u53ef\u80fd\u5728\u764c\u75c7\u9884\u540e\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u57282008\u5e74\u7684\u4e00\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u9996\u6b21\u5c06\u514d\u75ab\u9003\u9038\u7eb3\u5165\u4e86\u80bf\u7624\u5173\u952e\u5173\u952e\u7279\u5f81\uff0c\u5e76\u63d0\u51faIDO1\u4e0e\u8fd9\u79cd\u514d\u75ab\u9003\u9038\u76f8\u5173\u3002\u8fd9\u4e00\u89c2\u70b9\u6700\u7ec8\u88ab\u666e\u904d\u63a5\u53d7\uff0c\u56e0\u4e3a\u8be5\u89c2\u70b9\u8003\u8651\u5230\u4e86\u5bbf\u4e3b\u73af\u5883\u56e0\u7d20(\u5982\u514d\u75ab\u548c\u708e\u75c7)\u7684\u91cd\u8981\u6027\uff0c\u91cd\u65b0\u8bc4\u4f30\u4e86\u80bf\u7624\u7684\u5173\u952e\u7279\u5f81\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728DC\u548c\u5de8\u566c\u7ec6\u80de\u4e2d\u8bf1\u5bfcIDO1\u6765\u4fc3\u8fdb\u514d\u75ab\u8010\u53d7\u662f\u901a\u8fc7\u6291\u5236\u6548\u5e94\u6027T\u7ec6\u80de\uff0c\u5c06\u5e7c\u7a1aT\u7ec6\u80de\u8f6c\u5316\u4e3aFoxP3+Tregs\uff0c\u4ee5\u53ca\u63d0\u9ad8\u201c\u5929\u7136\u201dTregs\u7684\u6291\u5236\u6d3b\u6027\u6765\u5b9e\u73b0\u7684\u3002<\/p>\n

\u80bf\u7624\u5916IDO1\u7684\u8bf1\u5bfc\u6700\u521d\u662f\u5728\u4e00\u7ec4\u764c\u75c7\u60a3\u8005\u548c\u4e34\u5e8a\u524d\u80bf\u7624\u79fb\u690d\u6a21\u578b\u4e2d\u62a5\u9053\u7684\u3002\u5728\u5c0f\u9f20B16\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\uff0cIDO1\u4e0d\u80fd\u76f4\u63a5\u5728\u5f62\u6210\u7684\u80bf\u7624\u4e2d\u68c0\u6d4b\u5230\uff0c\u800c\u662f\u5728TDLN\u4e2d\u5347\u9ad8\uff0c\u5b9a\u4f4d\u4e8e\u5177\u6709T\u7ec6\u80de\u6291\u5236\u6d3b\u6027\u7684DC\u7279\u5b9a\u4e9a\u7fa4\u9644\u8fd1\u3002<\/p>\n

\u51e0\u79cd\u4e0d\u540c\u7684IDO1\u6291\u5236\u5316\u5408\u7269\u5df2\u7ecf\u88ab\u9274\u5b9a\u51fa\u6765\uff0c\u5b83\u4eec\u53ef\u4ee5\u663e\u8457\u6291\u5236B16\u80bf\u7624\u751f\u957f\uff0c\u8fd9\u79cd\u6291\u5236\u4f9d\u8d56\u4e8e\u5b8c\u6574\u7684T\u7ec6\u80de\u514d\u75ab\u548c\u5bbf\u4e3bIDO1\u529f\u80fd\uff0c\u8fd9\u4e3aIDO1\u5728\u9650\u5236\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u7624\u5916\u4f5c\u7528\u63d0\u4f9b\u4e86\u836f\u7406\u5b66\u652f\u6301\u3002<\/p>\n

\u4ee5\u540c\u6837\u7684\u65b9\u5f0f\uff0c\u5bf9IDO1\u53c2\u4e0e\u63a8\u52a8\u539f\u53d1\u80bf\u7624\u53d1\u5c55\u7684\u7b2c\u4e00\u4e2a\u9057\u4f20\u5b66\u9a8c\u8bc1\u6765\u81ea\u4e8e\u5bf9\u7ecf\u5178\u7684\u4e24\u671f\u76ae\u80a4\u764c\u53d1\u5c55\u6a21\u578b\u7684\u7814\u7a76\uff0c\u5728\u8fd9\u4e9b\u6a21\u578b\u4e2d\uff0c\u6ca1\u6709\u8bc1\u636e\u80fd\u8868\u660eIDO1\u5728\u53d1\u5c55\u4e2d\u75c5\u53d8\u4e2d\u8868\u8fbe\uff1b\u4e0eB16\u6a21\u578b\u76f8\u4f3c\uff0cIDO1\u5728TDLN\u5185\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u4e2d\u7684\u8868\u8fbe\u548c\u6d3b\u6027\u663e\u8457\u5347\u9ad8\u3002<\/p>\n

\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\u662f\u660e\u663e\u5206\u5f00\u7684\uff0cIDO1\u5728\u4fc3\u8fdb\u80bf\u7624\u7684\u708e\u75c7\u73af\u5883\u4e2d\u5347\u9ad8\uff0c\u5373\u4f7f\u5728\u6ca1\u6709\u80bf\u7624\u5f62\u6210\u7684\u60c5\u51b5\u4e0b\u4e5f\u662f\u5982\u6b64\uff0c\u8fd9\u6e05\u695a\u5730\u8868\u660e\u80bf\u7624\u5916\u7684IDO1\u5347\u9ad8\u662f\u5728\u542f\u52a8\u4fc3\u7624\u81f4\u7624\u7684\u708e\u75c7\u5fae\u73af\u5883\u7f16\u7a0b\u4e4b\u524d\u5c31\u53d1\u751f\u7684\u65e9\u671f\u4e8b\u4ef6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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17.3 \u708e\u75c7\u7f16\u7a0b\u4e2d\u7684IDO1\uff1aMDSC\u7684\u4ea7\u751f\u548c\u8f6c\u79fb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f9d\u8d56\u4e8eIDO1\u652f\u6301\u7684\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de(MDSC)\u662f\u5efa\u7acb\u514d\u75ab\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\u7684\u53e6\u4e00\u4e2a\u5173\u952e\u56e0\u7d20\u3002MDSC\u662f\u4e00\u7ec4\u672a\u6210\u719f\u7684\u9aa8\u9ad3\u6e90\u6027\u9020\u8840\u7ec6\u80de\uff0c\u5176\u529f\u80fd\u53d6\u51b3\u4e8e\u5176\u6291\u5236T\u7ec6\u80de\u6d3b\u6027\u7684\u80fd\u529b\u3002<\/p>\n

\u63a5\u6536\u708e\u75c7\u4fe1\u53f7\u540e\uff0cMDSCs\u8fc1\u79fb\u5230\u6dcb\u5df4\u3001\u813e\u548c\u80bf\u7624\u7ec4\u7ec7\uff0c\u4ee5\u4ea7\u751f\u5c40\u90e8\u514d\u75ab\u6291\u5236\u3002\u5728MDSC\u53d1\u6325\u5176T\u7ec6\u80de\u6291\u5236\u4f5c\u7528\u7684\u673a\u5236\u4e2d\uff0c\u6709\u8bc1\u636e\u8868\u660eIDO1\u6d3b\u6027\u662f\u4e00\u4e2a\u5173\u952e\u56e0\u7d20\u3002<\/p>\n

\u8fd9\u79cd\u8054\u7cfb\u5728\u5bf9IDO1\u2212\/\u2212\u5c0f\u9f20\u65b0\u751f\u80ba\u764c\u548c\u8f6c\u79fb\u6a21\u578b\u7684\u9057\u4f20\u5b66\u7814\u7a76\u4e2d\u9996\u6b21\u88ab\u53d1\u73b0\u3002IDO1\u2212\/\u2212\u5c0f\u9f20\u80fd\u62b5\u6297\u80ba\u80bf\u7624\u7684\u751f\u957f\uff0c\u800c\u4ece\u8377\u7624\u52a8\u7269\u83b7\u5f97\u7684MDSC\u5bf9\u4e8eCD8+\u548cCD4+ T\u7ec6\u80de\u7684\u6291\u5236\u662f\u51cf\u5f31\u7684\u3002<\/p>\n

\u6b64\u5916\uff0cIDO1\u7f3a\u5931\u53ef\u5bfc\u81f4MDSC\u7684\u4e3b\u8981\u9a71\u52a8\u529bIL-6\u7684\u51cf\u5f31\uff0c\u800c\u4e14IL-6\u7684\u5f02\u4f4d\u8868\u8fbe\u8db3\u4ee5\u9006\u8f6cIDO1\u2212\/\u2212\u5c0f\u9f20\u4e2dMDSC\u5bfc\u81f4\u7684T\u7ec6\u80de\u6291\u5236\u6d3b\u6027\u7684\u964d\u4f4e\u548c\u5bf9\u80ba\u8f6c\u79fb\u7684\u62b5\u6297\u80fd\u529b\u3002\u56e0\u6b64\uff0cIDO1\u901a\u8fc7\u5f71\u54cd\u708e\u75c7\u73af\u5883\u5bf9MDSC\u7684\u6291\u5236\u529f\u80fd\u53d1\u6325\u8c03\u63a7\u4f5c\u7528\u3002<\/p>\n

\u5176\u4ed6\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u7684MDSC\u52df\u96c6\u9700\u8981IDO1\u3002\u867d\u7136IDO1\u5728\u652f\u6301MDSC\u529f\u80fd\u4e2d\u8d77\u5230\u5173\u952e\u4f5c\u7528\uff0c\u4f46\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u6ca1\u6709\u4ee4\u4eba\u4fe1\u670d\u7684\u8bc1\u636e\u8868\u660eIDO1\u76f4\u63a5\u5728MDSC\u4e2d\u8868\u8fbe\u3002\u76f8\u53cd\uff0c\u4eba\u7c7b\u7814\u7a76\u5df2\u7ecf\u786e\u5b9a\u4e86\u8868\u8fbeIDO1\u7684MDSC\u7fa4\u4f53\uff0c\u5e76\u5c06\u8fd9\u4e9b\u7ec6\u80de\u4e2dIDO1\u7684\u8868\u8fbe\u4e0e\u514d\u75ab\u6291\u5236\u529f\u80fd\u8054\u7cfb\u8d77\u6765\u3002<\/p>\n

\u603b\u4f53\u800c\u8a00\uff0c\u9664\u4e86\u8c03\u63a7MDSC\u7684\u529f\u80fd\u548c\u52df\u96c6\u5916\uff0cIDO1\u8fd8\u53ef\u4ee5\u901a\u8fc7\u5176\u4ed6\u673a\u5236\u6765\u652f\u6301MDSC\u7684\u6d3b\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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17.4 \u708e\u75c7\u7f16\u7a0b\u4e2d\u7684IDO1\uff1a\u75c5\u7406\u6027\u8840\u7ba1\u65b0\u751f\u4e0e\u80bf\u7624\u8f6c\u79fb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u65b0\u8840\u7ba1\u751f\u6210\u5bf9\u652f\u6301\u80bf\u7624\u751f\u957f\u7684\u91cd\u8981\u6027\u5df2\u5f97\u5230\u5145\u5206\u8bc1\u5b9e\u3002<\/p>\n

\u867d\u7136\u8840\u7ba1\u751f\u6210\uff08angiogenesis\uff09\u6709\u65f6\u88ab\u7528\u6765\u6cdb\u6307\u6240\u6709\u8840\u7ba1\u7684\u53d1\u80b2\uff0c\u4f46\u5b83\u7684\u7279\u5b9a\u542b\u4e49\u662f\u4ece\u5148\u524d\u5b58\u5728\u7684\u8840\u7ba1\u7f51\u7edc\u4e2d\u5f62\u6210\u65b0\u7684\u8840\u7ba1\uff0c\u800c\u8840\u7ba1\u5efa\u6210\uff08vasculogenesis\uff09\u6307\u7684\u662f\u901a\u8fc7\u52df\u96c6\u65b0\u7684\u7ec6\u80de(\u5982\u9aa8\u9ad3\u6765\u6e90\u7684\u5185\u76ae\u524d\u4f53\u7ec6\u80de)\u5f62\u6210\u8840\u7ba1\u3002\u8840\u7ba1\u5efa\u6210\u4e3b\u8981\u4e0e\u80da\u80ce\u8840\u7ba1\u53d1\u80b2\u548c\u6210\u4eba\u8840\u7ba1\u751f\u6210\u6709\u5173\uff0c\u4f46\u60c5\u51b5\u53ef\u80fd\u66f4\u590d\u6742\uff0c\u8fd9\u4e24\u4e2a\u8fc7\u7a0b\u4e4b\u95f4\u7684\u533a\u522b\u53ef\u80fd\u4e0d\u662f\u7edd\u5bf9\u7684\u3002\u8840\u7ba1\u5efa\u6210\uff08vasculogenesis\uff09\u548c\u8840\u7ba1\u751f\u6210\uff08angiogenesis\uff09\u7684\u7ed3\u5408\u6d89\u53ca\u4ece\u4e2d\u80da\u5c42\u548c\u5185\u80da\u5c42\u8d77\u6e90\u7684\u5668\u5b98\u7684\u8840\u7ba1\u5f62\u6210\uff0c\u5982\u80ba\u3001\u5fc3\u3001\u80f0\u817a\u548c\u809d\u810f\uff0c\u800c\u5916\u80da\u5c42\u8d77\u6e90\u7684\u5668\u5b98\uff0c\u5982\u8111\u3001\u80be\u3001\u80f8\u817a\u548c\u80a2\u82bd\uff0c\u8840\u7ba1\u751f\u6210\u4f3c\u4e4e\u5360\u4e3b\u5bfc\u5730\u4f4d\u3002<\/p>\n

\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u89c2\u5bdf\u8868\u660e\uff0c\u5728\u4e0d\u540c\u7684\u7ec4\u7ec7\u73af\u5883\u4e2d\uff0c\u5f62\u6210\u65b0\u8840\u7ba1\u7684\u8fc7\u7a0b\u53ef\u80fd\u4e0d\u540c\uff0c\u8fd9\u53ef\u80fd\u662f\u5f71\u54cd\u80bf\u7624\u751f\u957f\u548c\u5728\u4f53\u5185\u4e0d\u540c\u90e8\u4f4d\u8f6c\u79fb\u7684\u4e00\u4e2a\u56e0\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7279\u522b\u662f\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u5e72\u6270\u7d20\u03b3\u5df2\u88ab\u8bc1\u660e\u80fd\u89e6\u53d1\u6297\u65b0\u751f\u8840\u7ba1\u6d3b\u6027\uff0c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u5728\u4e00\u7cfb\u5217\u7814\u7a76\u4e2d\uff0c\u5e72\u6270\u7d20\u03b3\u4ecb\u5bfc\u7684\u8840\u7ba1\u6e05\u9664\u88ab\u8ba4\u4e3a\u662fCD4\u548cCD8 T\u7ec6\u80de\u4f9d\u8d56\u7684\u80bf\u7624\u6392\u65a5\u53cd\u5e94\u7684\u4e3b\u8981\u673a\u5236\u3002<\/p>\n

\u7136\u800c\uff0c\u708e\u75c7\u662f\u4e00\u4e2a\u590d\u6742\u7684\u8fc7\u7a0b\uff0c\u4e5f\u53ef\u4ee5\u4fc3\u8fdb\u65b0\u751f\u8840\u7ba1\u7684\u5f62\u6210\u3002\u7279\u522b\u662f\uff0c\u708e\u6027\u7ec6\u80de\u56e0\u5b50IL6\u5df2\u88ab\u8bc1\u660e\u5bf9\u7f3a\u8840\u8bf1\u5bfc\u7684\u65b0\u751f\u8840\u7ba1\u975e\u5e38\u91cd\u8981\uff0c\u5e76\u5df2\u88ab\u8bc1\u660e\u53ef\u901a\u8fc7\u4e0d\u4f9d\u8d56\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u4fe1\u53f7\u8fc7\u7a0b\u4fc3\u8fdb\u5f02\u5e38\u8840\u7ba1\u751f\u6210\u3002<\/p>\n

IL6\u901a\u5e38\u4e5f\u88ab\u8ba4\u4e3a\u662f\u4fc3\u80bf\u7624\u7684\uff0c\u800c\u5e72\u6270\u7d20\u03b3\u5219\u88ab\u8ba4\u4e3a\u662f\u6297\u80bf\u7624\u7684\u3002\u8fd9\u8868\u660e\u708e\u75c7\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\u5e73\u8861\u5f88\u53ef\u80fd\u901a\u8fc7\u5f71\u54cd\u65b0\u751f\u8840\u7ba1\u6765\u5f71\u54cd\u80bf\u7624\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u5728\u6b64\u80cc\u666f\u4e0b\uff0c\u53d1\u73b0IDO1\u7684\u7f3a\u5931\u5bfc\u81f4\u80ba\u8840\u7ba1\u5f62\u6210\u51cf\u5c11\uff0c\u5e76\u7531\u6b64\u63d0\u51fa\u5047\u8bbe\uff0c\u5373\u5e72\u6270\u7d20\u03b3\u8bf1\u5bfcIDO1\u53ef\u80fd\u4ee5\u8d1f\u53cd\u9988\u65b9\u5f0f\u53d1\u6325\u4f5c\u7528\uff0c\u4ece\u800c\u9650\u5236\u5e72\u6270\u7d20\u03b3\u7684\u6297\u8840\u7ba1\u751f\u6210\u4f5c\u7528\uff0c\u8fd9\u53ef\u80fd\u662fIDO1\u5bf9\u6297\u57fa\u4e8e\u514d\u75ab\u7684\u80bf\u7624\u751f\u957f\u9650\u5236\u7684\u91cd\u8981\u9014\u5f84\u3002<\/p>\n

IDO1\u7f3a\u5931\u8fd8\u4e0e\u708e\u6027\u7ec6\u80de\u56e0\u5b50IL6\u7684\u8bf1\u5bfc\u51cf\u5f31\u6709\u5173\uff0c\u5728\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\uff0cIL6\u7684\u5f02\u4f4d\u8868\u8fbe\u53ef\u4ee5\u524a\u5f31IDO1\u2212\/\u2212\u5c0f\u9f20\u5bf9\u80bf\u7624\u8f6c\u79fb\u7684\u62b5\u6297\u3002\u6839\u636e\u8fd9\u4e9b\u53d1\u73b0\u63d0\u51fa\u4e86\u5047\u8bbe\uff0c\u4ece\u80bf\u7624\u53d1\u751f\u5f00\u59cb\uff0cIDO1\u4f5c\u7528\u4e8e\u5e72\u6270\u7d20\u03b3\u7684\u4e0b\u6e38\u548cIL6\u7684\u4e0a\u6e38\uff0c\u4f7f\u708e\u75c7\u73af\u5883\u5411\u8840\u7ba1\u751f\u6210\u548c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u7684\u65b9\u5411\u8f6c\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u6b63\u5982\u8be5\u6a21\u578b\u6240\u9884\u6d4b\u7684\u90a3\u6837\uff0c\u4e0e\u91ce\u751f\u578b\u5bf9\u7167\u5c0f\u9f20\u76f8\u6bd4\uff0cIDO 1\u2212\/\u2212\u5c0f\u9f20\u80ba\u8f6c\u79fb\u7624\u7684\u65b0\u751f\u8840\u7ba1\u663e\u8457\u51cf\u5c11\u3002\u7136\u800c\uff0c\u7531\u4e8eIDO1\u2212\/\u2212\u5c0f\u9f20\u7684\u6574\u4f53\u8f6c\u79fb\u6027\u80bf\u7624\u751f\u957f\u4e5f\u88ab\u663e\u8457\u6291\u5236\uff0c\u6240\u4ee5\u5c1a\u4e0d\u6e05\u695a\u8840\u7ba1\u5f62\u6210\u7684\u51cf\u5c11\u662f\u5426\u662fIDO1\u7f3a\u5931\u7684\u76f4\u63a5\u5f71\u54cd\u3002<\/p>\n

\u4e3a\u4e86\u9a8c\u8bc1IDO1\u5bf9\u4e8e\u652f\u6301\u8840\u7ba1\u65b0\u751f\u5341\u5206\u91cd\u8981\u8fd9\u4e00\u89c2\u70b9\u662f\u5426\u88ab\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5176\u4ed6\u6df7\u6742\u6548\u5e94\u5f71\u54cd\uff0c\u6211\u4eec\u5bf9\u5c0f\u9f20OIR(\u6c27\u6e90\u6027\u89c6\u7f51\u819c\u75c5\u53d8)\u6a21\u578b\u8fdb\u884c\u4e86\u7814\u7a76\u3002OIR\u6a21\u578b\u662f\u4e00\u4e2a\u6210\u719f\u7684\u3001\u53ef\u91cd\u73b0\u7684\u7814\u7a76\u65b0\u751f\u8840\u7ba1\u7684\u66ff\u4ee3\u7cfb\u7edf\u3002\u6b63\u5982\u9884\u6d4b\u7684\u90a3\u6837\uff0c\u4e0eWT\u5c0f\u9f20\u76f8\u6bd4\uff0cIDO 1\u2212\/\u2212\u5c0f\u9f20\u5728OIR\u8bf1\u5bfc\u7684\u89c6\u7f51\u819c\u65b0\u751f\u8840\u7ba1\u65b9\u9762\u8868\u73b0\u51fa\u663e\u8457\u7684\u51cf\u5c11\u3002\u800c\u76f8\u5173\u7684IDO2\u4e9a\u578b\u7684\u7f3a\u5931\u5bf9OIR\u8bf1\u5bfc\u7684\u89c6\u7f51\u819c\u65b0\u751f\u8840\u7ba1\u6ca1\u6709\u660e\u663e\u7684\u5f71\u54cd\uff0c\u8868\u660e\u8fd9\u79cd\u5f71\u54cd\u662fIDO1\u6240\u7279\u6709\u7684\u3002<\/p>\n

IDO1\u2212\/\u2212\u7ec4\u548cWT\u7ec4\u5728\u5e38\u6c27\u6761\u4ef6\u4e0b\u7684\u6b63\u5e38\u89c6\u7f51\u819c\u8840\u7ba1\u5f62\u6210\u6ca1\u6709\u5dee\u5f02\uff0c\u800cIDO1\u2212\/\u2212\u52a8\u7269\u4e2d\u6b63\u5e38\u8840\u7ba1\u518d\u751f\u5f62\u6210\u7684\u65e0\u8840\u7ba1\u533a\u57df\u51cf\u5c11\u66f4\u591a\uff0c\u8868\u660e\u5728\u7f3a\u4e4fIDO1\u7684\u5c0f\u9f20\u4e2d\uff0c\u6b63\u5e38\u8840\u7ba1\u518d\u751f\u5f97\u5230\u6539\u5584\u3002<\/p>\n

\u5728\u7f3a\u4e4fIDO1\u57fa\u56e0\u7684\u5c0f\u9f20\u4e2d\u89c2\u5bdf\u5230\u7684OIR\u8bf1\u5bfc\u7684\u89c6\u7f51\u819c\u65b0\u751f\u8840\u7ba1\u7684\u51cf\u5c11\u662f\u901a\u8fc7siRNA\u4ecb\u5bfc\u7684IDO1\u5728\u89c6\u7f51\u819c\u4e2d\u7684\u8868\u8fbe\u4e0b\u8c03\u6765\u5b9e\u73b0\u7684\uff0c\u8868\u660eIDO1\u7f3a\u5931\u53ef\u4ee5\u4ece\u5c40\u90e8\u548c\u6025\u6027\u4e24\u65b9\u9762\u5f15\u8d77\u5bf9\u65b0\u751f\u8840\u7ba1\u7684\u5f71\u54cd\u3002<\/p>\n

\u540c\u6837\uff0c\u4e34\u5e8a\u836f\u7269\u827e\u5361\u54da\u53f8\u4ed6\uff08epacadostat\uff09\u5bf9IDO1\u7684\u836f\u7406\u6291\u5236\u51cf\u5c11\u4e86\u5168\u8eab\u7ed9\u836f\u65f6OIR\u8bf1\u5bfc\u7684\u89c6\u7f51\u819c\u65b0\u751f\u8840\u7ba1\u3002\u7c7b\u4f3c\u7814\u7a76\u4e2d\uff0c\u5728\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\u7ed9\u4e88\u827e\u5361\u54da\u53f8\u4ed6\u53ef\u8fc5\u901f\u6d88\u9664\u73b0\u6709\u7684\u65b0\u751f\u8840\u7ba1\uff0c\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u53d1\u73b0\u5728\u764c\u75c7\u73af\u5883\u4e2d\u7684\u6f5c\u5728\u6cbb\u7597\u53ef\u80fd\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u5728\u786e\u5b9a\u4e86IDO1\u5bf9\u652f\u6301\u65b0\u751f\u8840\u7ba1\u7684\u91cd\u8981\u4f5c\u7528\u540e\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u4ee5\u9a8c\u8bc1IDO1\u901a\u8fc7\u6574\u5408\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u5e72\u6270\u7d20\u03b3\u548cIL6\u4e4b\u95f4\u7684\u8c03\u8282\u800c\u4ea7\u751f\u8fd9\u79cd\u4f5c\u7528\u7684\u5047\u8bbe\u3002<\/p>\n

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\u6b64\u5916\uff0c\u6b63\u5982\u9884\u6d4b\u7684\u90a3\u6837\uff0cIL6\u2212\/\u2212\u5c0f\u9f20\u5728OIR\u548c\u8f6c\u79fb\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u65b0\u751f\u8840\u7ba1\u51cf\u5c11\u7684\u73b0\u8c61\uff0c\u4e0eIDO1\u2212\/\u2212\u5c0f\u9f20\u7684\u89c2\u5bdf\u7ed3\u679c\u76f8\u4f3c\u3002\u5728IFNG\u2212\/\u2212 IL6\u2212\/\u2212\u53cc\u57fa\u56e0\u6572\u9664\u7684\u5c0f\u9f20\u4e2d\uff0cIL6\u7f3a\u5931\u5bf9\u65b0\u751f\u8840\u7ba1\u7684\u5f71\u54cd\u540c\u6837\u56e0\u5e72\u6270\u7d20\u03b3\u7684\u6e05\u9664\u800c\u88ab\u9006\u8f6c\uff0c\u8fd9\u8868\u660eIL6\u7684\u4fc3\u8840\u7ba1\u751f\u6210\u6d3b\u6027\u5f88\u53ef\u80fd\u662f\u56e0\u4e3a\u4ece\u4e0a\u6e38\u589e\u5f3a\u4e86IDO1\u5bf9\u8840\u7ba1\u65b0\u751f\u7684\u4fc3\u8fdb\u3002<\/p>\n

\u5728\u6240\u6709\u75c5\u4f8b\u4e2d\uff0c\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\u7684\u65b0\u751f\u8840\u7ba1\u4e0e\u603b\u5b58\u6d3b\u7387\u5bc6\u5207\u76f8\u5173\uff0c\u8fd9\u8868\u660e\u5bf9\u80bf\u7624\u65b0\u751f\u8840\u7ba1\u7684\u5f71\u54cd\u53ef\u80fd\u662fIDO1\u6291\u5236\u5242\u6cbb\u7597\u7684\u4e00\u4e2a\u6709\u610f\u4e49\u7684\u7ed3\u679c\uff0c\u5e94\u8be5\u4f5c\u4e3a\u8fd9\u4e9b\u836f\u7269\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u5f00\u53d1\u7684\u4e00\u90e8\u5206\u52a0\u4ee5\u8003\u8651\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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17.5 B\u7ec6\u80de\u708e\u75c7\u72b6\u6001\u4e0b\u7684IDO2\u548cIDO1\u7684\u67d0\u4e9b\u529f\u80fd\uff1a\u8054\u7cfb\u548c\u95ee\u9898<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c0f\u9f20\u9057\u4f20\u5b66\u5b9e\u9a8c\u8bc1\u5b9e\u4e86IDO2\u5728\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\u3002IDO2\u7f3a\u9677\u5c0f\u9f20\u7684\u4e00\u4e2a\u663e\u8457\u7279\u5f81\u662f\u7f3a\u4e4f\u652f\u6301IDO1\u8bf1\u5bfc\u7684\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u80fd\u529b\u3002\u5df2\u6709\u7c7b\u4f3c\u8bc1\u636e\u8868\u660e\uff0c\u4eba\u7c7b\u6811\u7a81\u72b6\u7ec6\u80de\u5bf9IDO2\u5177\u6709\u7c7b\u4f3c\u7684\u8010\u53d7\u529f\u80fd\u3002IDO1\u57fa\u56e0\u7f3a\u9677\u5c0f\u9f20\u4e5f\u88ab\u53d1\u73b0\u5b58\u5728IDO2\u529f\u80fd\u7684\u5d4c\u5408\u4f53\u7f3a\u9677\uff0c\u8fd9\u52a0\u5f3a\u4e86IDO1\u3001IDO2\u76f8\u4e92\u4f5c\u7528\u5728\u514d\u75ab\u63a7\u5236\u4e2d\u7684\u7ebf\u7d22\u3002Fig. 17.2<\/span>\u603b\u7ed3\u4e86IDO2\u7684\u8fd9\u4e00\u7279\u5f81\u548c\u4e00\u4e2a\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u8868\u660e\u4e86\u5b83\u5728\u764c\u75c7\u4e2d\u7684\u6f5c\u5728\u529f\u80fd\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u81ea\u8eab\u514d\u75ab\u6027\u5173\u8282\u708e\u7684\u6a21\u578b\u4e2d\uff0c\u5432\u54da\u83ab\u5fb7(D-1MT)\u7684\u5e94\u7528\u4f7f\u5f97\u4e0eIDO2\u7f3a\u5931\u76f8\u5173\u7684\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u964d\u4f4e\uff0c\u8fd9\u79cd\u6cbb\u7597\u6548\u679c\u56e0IDO1\u7f3a\u5931\u800c\u6d88\u5931\uff0c\u4e0e\u5432\u54da\u83ab\u5fb7\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u7834\u574fIDO2\u9176\u7684\u6d3b\u6027\u8fd9\u4e00\u65e9\u671f\u8bc1\u636e\u4e00\u81f4\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u8054\u7cfb\u53ef\u80fd\u662f\u4e0e\u5176\u4e0a\u4e0b\u6e38\u76f8\u5173\u7684\uff0c\u8fd8\u6709\u5f85\u5728\u5176\u4ed6\u7cfb\u7edf\u4e2d\u6269\u5c55\uff0c\u4f8b\u5982\u53ef\u80fd\u4e0e\u4eba\u7c7b\u4e2dIDO2\u964d\u4f4e\u8272\u6c28\u9178\u5206\u89e3\u4ee3\u8c22\u6d3b\u6027\u7684\u5e38\u89c1\u57fa\u56e0\u53d8\u5f02\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u8fd1\u5173\u4e8eIDO2\u2212\/\u2212\u5c0f\u9f20\u5bf9\u81ea\u8eab\u514d\u75ab\u6027\u5173\u8282\u708e\u6613\u611f\u6027\u964d\u4f4e\u7684\u7814\u7a76\u8868\u660e\uff0cIDO2\u5728B\u7ec6\u80de\u4e2d\u53d1\u6325\u529f\u80fd\uff0c\u652f\u6301B\u7ec6\u80de\u708e\u75c7\u72b6\u6001\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f88\u6709\u8da3\uff0c\u56e0\u4e3a\u6709\u8bc1\u636e\u8868\u660e\uff0c\u67d0\u4e9b\u764c\u75c7\u7684\u53d1\u5c55\u4f9d\u8d56\u4e8eB\u7ec6\u80de\u708e\u75c7\u72b6\u6001\u3002\u867d\u7136IDO2\u7f3a\u4e4f\u7684\u5c0f\u9f20\u5bf9\u708e\u75c7\u6027\u76ae\u80a4\u764c\u7684\u6613\u611f\u6027\u6ca1\u6709\u53d8\u5316\uff0c\u4f46\u5b83\u4eec\u62b5\u6297K-RAS\u8bf1\u5bfc\u7684\u80f0\u817a\u764c\u7684\u53d1\u5c55(G.C.Prendergast\u548cA.J.Muller\uff0c\u672a\u53d1\u8868\u7684\u6570\u636e)\u3002IDO2\u9176\u5b66\u4e0eIDO1\u7684\u4e0d\u540c\u4e4b\u5904\u5728\u4e8e\u9700\u8981\u4e0d\u540c\u7684\u8fd8\u539f\u7cfb\u7edf\uff0c\u5c24\u5176\u662f\u5bf9\u4eba\u7c7b\u7684\u9176\uff0c\u4f46\u6700\u8fd1\u5bf9\u8fd9\u4e9b\u5dee\u5f02\u7684\u9610\u660e\u8bc1\u5b9e\uff0cIDO2\u5177\u6709\u660e\u663e\u7684\u8272\u6c28\u9178\u5206\u89e3\u4ee3\u8c22\u6d3b\u6027\u3002\u867d\u7136\u5df2\u7ecf\u62a5\u9053\u4e86\u9f20\u6216\u4eba\u7684IDO2\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u4f46\u5b83\u4eec\u6ca1\u6709\u751f\u7269\u6d3b\u6027\uff0c\u6216\u8005\u7531\u4e8e\u5176\u4ed6\u539f\u56e0\u8fd8\u6ca1\u6709\u5728\u4f53\u5185\u8fdb\u884c\u7814\u7a76\u3002\u6709\u8da3\u7684\u662f\uff0c\u6700\u8fd1\u62a5\u9053\u4e86\u4e00\u79cd\u9488\u5bf9IDO2\u7684B\u7ec6\u80de\u7a7f\u900f\u6027\u751f\u7269\u6d3b\u6027\u6297\u4f53\uff0c\u8be5\u6297\u4f53\u5728IDO2\u57fa\u56e0\u7f3a\u9677\u5c0f\u9f20\u4e2d\u5177\u6709\u6297\u5173\u8282\u708e\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\uff0cIDO2\u7684\u8868\u8fbe\u8303\u56f4\u6bd4IDO1\u6216TDO\u66f4\u7a84\uff0c\u4e3b\u8981\u5c40\u9650\u4e8e\u809d\u3001\u80be\u3001\u8111\u3001\u80ce\u76d8\u548cB\u7ec6\u80de\u3001\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u3002\u764c\u75c7\u5e76\u4e0d\u503e\u5411\u4e8e\u8fc7\u5ea6\u8868\u8fbeIDO2\uff0c\u5c3d\u7ba1\u5728\u9ed1\u8272\u7d20\u7624\u4ee5\u53ca\u80c3\u3001\u8111\u548c\u80f0\u817a\u80bf\u7624\u4e2d\u90fd\u6709\u62a5\u9053\uff0c\u4f46\u540e\u8005\u7684\u60c5\u51b5\u76f8\u8f83\u5e7f\u6cdb\u3002IDO2\u7531\u82b3\u70c3\u53d7\u4f53(AhR)\u8c03\u8282\uff0c\u8be5\u53d7\u4f53\u662f\u7531\u66f4\u6d3b\u8dc3\u7684IDO1\u9176\u4ea7\u751f\u7684\u5185\u6e90\u6027\u914d\u4f53\uff0c\u4e0e\u72ac\u5c3f\u6c28\u9178\u7ed3\u5408\u3002\u56e0\u6b64\uff0c\u7ed9\u51faIDO1-IDO2\u76f8\u4e92\u4f5c\u7528\u7684\u7ebf\u7d22\uff0c\u53ef\u4ee5\u60f3\u8c61\uff0c\u5c40\u90e8IDO1\u6d3b\u6027\u53ef\u80fd\u4f1a\u589e\u52a0\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6d41\u52a8\u7684\u6297\u539f\u63d0\u5448\u7ec6\u80de\u4e2d\u7684IDO2\u6c34\u5e73\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3(TDLN)\u4e2dTreg\u5f62\u6210\u7684\u8010\u53d7\u72b6\u6001\u3002Fig. 17.2<\/span>\u5c55\u793a\u4e86\u4e00\u4e2a\u6a21\u578b\uff0c\u5728\u8be5\u6a21\u578b\u4e2d\uff0cIDO2\u5728IDO1\/TDO\u4e0b\u6e38\u7684Kyn\u6548\u5e94\u901a\u8def\u4e0a\u53d1\u6325\u4f5c\u7528\uff0c\u4ee5\u79ef\u6781\u5730\u53c2\u4e0eTDLN\u4e2d\u81ea\u8eab\u514d\u75ab\u6216\u80bf\u7624\u65f6\u6297\u539f\u514d\u75ab\u8010\u53d7\u7684\u5f62\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 17.2<\/span> IDO2\u662fIDO1\u4ecb\u5bfc\u514d\u75ab\u8010\u53d7\u7684\u8d21\u732e\u8005\u3002 (a) IDO2\u7f3a\u9677\u5c0f\u9f20\u5728\u4f9d\u8d56PD1\u7684IDO1\u4ecb\u5bfc\u7684Treg\u8bf1\u5bfc\u673a\u5236\u4e0a\u5b58\u5728\u7f3a\u9677\uff0c\u8fd9\u652f\u6301\u4e86\u5176\u4ed6\u8868\u660eIDO1\u548cIDO2\u5728\u5c0f\u9f20\u4e2d\u5b58\u5728\u9057\u4f20\u76f8\u4e92\u4f5c\u7528\u7684\u8bc1\u636e\u3002 (b) \u6a21\u578b\u3002APC\u4e2d\u7531Kynurenine\/AhR\u4fe1\u53f7\u6fc0\u6d3b\u7684IDO2\u8868\u8fbe\u53ef\u5c06IDO1\u5728\u80bf\u7624\u548c\u80bf\u7624\u95f4\u8d28\u7ec6\u80de(\u84dd\u8272\u80bf\u7624\u4e2d\u7684\u7070\u8272\u6216\u7c89\u7ea2\u8272\u7ec6\u80de)\u4e2d\u4ea7\u751f\u7684\u8010\u53d7\u4fe1\u53f7\u8fdc\u8ddd\u79bb\u4f20\u64ad\u3002\u5c40\u90e8\u8868\u8fbeIDO1\u949d\u5316\u4e86\u7531\u72ac\u5c3f\u6c28\u9178\u751f\u4ea7\u4e0e\u8272\u6c28\u9178\u5265\u593a\u4ecb\u5bfc\u7684\u6297\u539f\u7279\u5f02\u6027\u6548\u5e94T\u7ec6\u80de\u3002\u5728APC\u4e2d\uff0cIDO2\u7684\u8868\u8fbe\u662f\u901a\u8fc7IDO1\u4ecb\u5bfc\u7684\u72ac\u5c3f\u6c28\u9178\u7684\u4ea7\u751f\u800c\u4e0a\u8c03\u7684\uff0c\u72ac\u5c3f\u6c28\u9178\u901a\u8fc7\u5176\u53d7\u4f53AhR\u9a71\u52a8APC\u4e2dIDO2\u7684\u8f6c\u5f55\u3002IDO2\u6d3b\u6027\u662f\u7531IDO1\u901a\u8fc7\u8f6c\u5f55\u548c\u8f6c\u5f55\u540e\u673a\u5236\u4ecb\u5bfc\u7684\u3002\u72ac\u5c3f\u6c28\u9178\u5bf9APC\u5177\u6709\u8010\u53d7\u6027\uff0c\u5728\u8be5\u6a21\u578b\u4e2dIDO2\u4f5c\u4e3a\u6548\u5e94\u5668\u88ab\u6fc0\u6d3b\u3002IDO2\u901a\u8fc7\u4e0d\u540c\u4e8eIDO1\u53ef\u9006\u4fe1\u53f7\u7684\u4e0d\u53ef\u9006\u4fe1\u53f7\u589e\u5f3aAPC\u7684\u8010\u53d7\u6027\u3002\u7531IDO2\u8c03\u63a7\u7684APC\u6e38\u8d70\u5230\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3(\u7eff\u8272TDLN)\u6216\u5176\u4ed6\u8f6c\u79fb\u90e8\u4f4d\uff0c\u52a0\u5f3a\u4e86\u8fd9\u4e9b\u533a\u57df\u7684IDO1\u4f9d\u8d56\u6027Treg\u7684\u5f62\u6210(IDO1\u4e5f\u5728APC\u4e2d\u8868\u8fbe\uff0c\u4f46\u4e3a\u6e05\u695a\u8d77\u89c1\u672a\u663e\u793a)\u3002\u5728IDO2\u7f3a\u4e4f\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cIDO2\u4f5c\u4e3a\u5fc5\u9700\u7684\u4e2d\u95f4\u529f\u80fd\u53d1\u6325\u4f5c\u7528\uff0c\u5e76\u4e14\u8be5\u6a21\u578b\u4e0eTreg\u5f62\u6210\u4e2d\u7814\u7a76IDO1\u529f\u80fd\u7684\u6700\u65b0\u6a21\u578b\u76f8\u517c\u5bb9\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/section>\n
for Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 | George C. Prendergast, William J. Malachowski, Arpita Mondal, Peggy Scherle, and Alexander J. Muller<\/span><\/section>\n
\u7ffb\u8bd1 |  \u949f\u96ea\u83b9 \u9648\u6653\u610f \u8d75\u6db5 \u90d1\u68a6\u6021<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u7ae0\u9707<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u5218\u7389\u5a07 \u4f55\u4e3d\u5a1c<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n


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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

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