{"id":4857,"date":"2023-02-22T19:58:27","date_gmt":"2023-02-22T11:58:27","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/02\/22\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac18%e7%ab%a0%ef%bc%9a%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e6%80%a7%e6%8a%97%e4%bd%93%ef%bc%88%e4%b8%8b%ef%bc%89\/"},"modified":"2023-02-22T19:58:27","modified_gmt":"2023-02-22T11:58:27","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac18%e7%ab%a0%ef%bc%9a%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e6%80%a7%e6%8a%97%e4%bd%93%ef%bc%88%e4%b8%8b%ef%bc%89","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/02\/22\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac18%e7%ab%a0%ef%bc%9a%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e6%80%a7%e6%8a%97%e4%bd%93%ef%bc%88%e4%b8%8b%ef%bc%89\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c18\u7ae0\uff1a\u80bf\u7624\u9776\u5411\u6027\u6297\u4f53\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c18\u7ae0\uff1a\u80bf\u7624\u9776\u5411\u6027\u6297\u4f53\uff08\u4e0a\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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18.4 <\/span>\u4ece\u80bf\u7624\u9776\u5411\u5355\u6297\u5230\u514d\u75ab\u9776\u5411\u5355\u6297<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3d\u7ba1\u80bf\u7624\u9776\u5411\u5355\u6297\u5df2\u7ecf\u6709\u826f\u597d\u7684\u4e34\u5e8a\u7597\u6548\u5e76\u6210\u4e3a\u4e00\u4e9b\u764c\u75c7\u7684\u65e2\u5b9a\u7597\u6cd5\uff0c\u4f46\u8bb8\u591a\u6297\u80bf\u7624\u5355\u6297\u7684\u4e34\u5e8a\u5f00\u53d1\u8fd8\u662f\u5931\u8d25\u4e86\u3002<\/p>\n

\u8981\u4e48\u662f\u56e0\u4e3a\u5b83\u4eec\u4e0d\u80fd\u6709\u6548\u5730\u89e6\u53d1\u5bbf\u4e3b\u6548\u5e94\u673a\u5236(\u5982\u9776\u6297\u539f\u8868\u8fbe\u6c34\u5e73\u4f4e\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u4f4e\u7b49)\u3002\u6216\u7531\u4e8e\u9776\u6297\u539f\u4e0b\u8c03\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u9003\u9038(\u4f8b\u5982\uff0cB\u7ec6\u80de\u6dcb\u5df4\u7624\u7ec6\u80de\u4e0b\u8c03CD20\u8868\u8fbe\u5448\u9634\u6027)\u3002\u6b64\u5916\uff0c\u4e0e\u5176\u4ed6\u88ab\u52a8\u7597\u6cd5\u4e00\u6837\uff0c\u80bf\u7624\u9776\u5411\u5355\u6297\u4ec5\u5728\u60a3\u8005\u4f53\u5185\u5b58\u5728\u65f6\u6709\u6548\uff0c\u800c\u4e00\u65e6\u505c\u6b62\u6cbb\u7597\uff0c\u5c31\u53ef\u80fd\u590d\u53d1\u3002<\/p>\n

\u901a\u8fc7\u9776\u5411T\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u5171\u523a\u6fc0\/\u5171\u6291\u5236\u4fe1\u53f7\u6765\u523a\u6fc0\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u53ef\u80fd\u4f1a\u4ea7\u751f\u79ef\u6781\u548c\u6301\u4e45\u7684\u6297\u80bf\u7624\u514d\u75ab\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u5e76\u4e0d\u662f\u9776\u5411\u7279\u5b9a\u7684\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff0c\u6240\u4ee5<\/span>\u8fd9\u79cd\u514d\u75ab\u8c03\u8282\u5355\u6297\u5e76\u975e\u75be\u75c5\u7279\u5f02\u6027\u7684\uff0c\u53ef\u4ee5\u5b9e\u73b0\u9488\u5bf9\u591a\u79cd\u80bf\u7624\u6297\u539f\u7684\u5e7f\u6cdb\u7684\u6297\u80bf\u7624\u514d\u75ab\uff0c\u56e0\u6b64\u53ef\u4ee5\u66f4\u597d\u5730\u89e3\u51b3\u764c\u75c7\u7684\u5f02\u8d28\u6027\u5e76\u51cf\u5c11\u514d\u75ab\u9003\u9038\u7684\u673a\u4f1a\u3002<\/p>\n

FDA\/EMA\u6279\u51c6\u7684\u7b2c\u4e00\u6279\u514d\u75ab\u9776\u5411\u5355\u6297\u9488\u5bf9\u7684\u662fCTLA-4\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f4\uff09\u3001PD-1\u548cPD-L1\uff08\u7a0b\u5e8f\u6027\u6b7b\u4ea1-1\u6297\u539f\u53ca\u5176\u914d\u4f53\uff09\u3002\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u6240\u6709\u6297PD-1\u548c\u6297PD-L1\u6297\u4f53\u90fd\u662f\u7eaf\u5316\u7684\u62ee\u6297\u6027\u5355\u6297\uff0c\u5b83\u4eec\u5177\u6709IgG4\u578b\uff08\u5982\u6765\u81eaBMS\u7684nivolumab, \u6765\u81eaMerck\/MSD\u7684pembrolizumab\uff09\u6216\u5e26\u6709\u7a81\u53d8\u7684IgG1\u578b\uff08\u5982Roche\u7684atezolizumab \u548cAstraZeneca\u7684durvalumab\uff09\uff0c\u4ee5\u9632\u6b62\u4e0eFc\u03b3R\u7ed3\u5408\u3002<\/p>\n

\u552f\u4e00\u7684\u4f8b\u5916\u662fAvelumab\uff08\u963f\u97e6\u9c81\u5355\u6297\uff09\uff0c\u5b83\u662f\u4e00\u79cd\u672a\u7ecf\u4fee\u9970\u7684IgG1\u6297PD-L1\u6297\u4f53\u3002\u56e0\u6b64\uff0cAvelumab\u8fd8\u53ef\u4ee5\u7528\u4f5c\u9488\u5bf9\u5177\u6709PD-L1\u9633\u6027\u80bf\u7624\u7ec6\u80de\u7684\u764c\u75c7\u7684\u80bf\u7624\u9776\u5411\u5355\u6297\u3002\u672c\u7740\u540c\u6837\u7684\u60f3\u6cd5\uff0cipilimumab\uff08\u4f0a\u5339\u6728\u5355\u6297\uff09\u662f\u7b2c\u4e00\u4e2a\u88ab\u6279\u51c6\u7684\u6297CTLA-4\u5355\u6297\uff0c\u4e5f\u662f\u4e00\u79cd\u672a\u7ecf\u4fee\u9970\u7684IgG1\u578b\u6297\u4f53\uff0c\u7406\u8bba\u4e0a\u4e5f\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597CTLA-4\u9633\u6027\u7684T\u7ec6\u80de\u6076\u6027\u80bf\u7624\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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18.5 <\/span>\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff1a\u540c\u65f6\u9776\u5411\u80bf\u7624\u548c\u514d\u75ab<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u5355\u6297\u8bbe\u8ba1\u6280\u672f\u7684\u8fdb\u6b65\u4f7f\u6211\u4eec\u80fd\u591f\u6784\u5efa\u51fa\u5177\u6709\u53cc\u91cd\u7279\u5f02\u6027\u7684\u6297\u4f53\uff0c\u5176\u6709\u4e24\u4e2a\u72ec\u7279\u7684\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\uff0c\u80fd\u591f\u5b9e\u73b0\u4e0e\u591a\u4e2a\u9776\u70b9\u7684\u7ed3\u5408 \u3002<\/p>\n

\u8bbe\u8ba1\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7684\u76ee\u7684\u662f\u9a71\u4f7fT\u7ec6\u80de\u6740\u4f24\u9776\u7ec6\u80de\u3002\u4f8b\u5982\uff0c\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u63a5\u5408\u5668(BiTEs\u2122)\u662f\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7684\u4e00\u79cd\u7c7b\u578b\uff0c\u662f\u7531\u4e0d\u540c\u6297\u4f53\u7684\u4e24\u4e2a\u5355\u94fe\u53ef\u53d8\u7247\u6bb5(scFvs)\u7ec4\u6210\u7684\u878d\u5408\u86cb\u767d\u3002\u5176\u4e2d\u4e00\u79cdscFvs(\u5355\u94fe\u6297\u4f53)\u901a\u8fc7CD3\u53d7\u4f53\u4e0eT\u7ec6\u80de\u7ed3\u5408\u5e76\u6fc0\u6d3bT\u7ec6\u80de\u3002\u53e6\u4e00\u79cdscFv\u901a\u8fc7\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u4e0e\u80bf\u7624\u7ec6\u80de\u7ed3\u5408\u3002<\/p>\n

\u4f8b\u5982\uff0cMicromet\/Amgen\u5f00\u53d1\u7684\u6297CD3\/\u6297CD19 \u7684blinatumab\uff08\u535a\u7eb3\u5410\u5355\u6297\uff09\u6297\u4f53\u5c31\u662f\u8fd9\u79cd\u60c5\u51b5\uff0c\u5176\u76ee\u524d\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027B\u7ec6\u80de\u767d\u8840\u75c5\uff0c\u5e76\u5728B\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u4e34\u5e8a\u6709\u6548\u6027\u3002<\/p>\n

\u8bb8\u591a\u53cc\u7279\u5f02\u6027\u6297\u4f53\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u5f00\u53d1\u4e2d\uff0c\u5305\u62ec\u9488\u5bf9\u5b9e\u4f53\u7624\u7684\u3002\u5176\u4e2d\u4e00\u4e9b\u662f\u5177\u6709\u4e24\u4e2aFabs\u548c\u4e00\u4e2aFc\u7ed3\u6784\u57df\u7684\u5168\u957f\u6297\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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18.6<\/span>\u80bf\u7624\u9776\u5411\u6297\u4f53\u7684\u6311\u6218\u4e0e\u5c55\u671b<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f8b\u5982\uff0c\u6297CD137\u6fc0\u52a8\u578b\u6297\u4f53\u5df2\u88ab\u8bc1\u660e\uff0c\u5f53\u4e0eCD20\u3001HER2\u6216EGFR\u80bf\u7624\u9776\u5411\u6297\u4f53\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u53ef\u4ee5\u589e\u5f3aNK\u7ec6\u80deADCC\uff08\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\uff09\u6548\u5e94\u548cCD8+<\/sup>T\u7ec6\u80de\u7684\u53cd\u5e94\u3002\u5df2\u8bc1\u660e\u6297KIR\u6297\u4f53\u53ef\u4ee5\u901a\u8fc7\u6a21\u62dfNK\u7ec6\u80de\u4e0a\u7684\u201c\u7f3a\u5931\u81ea\u6211\u201d\u4fe1\u53f7\u6765\u589e\u5f3a\u80bf\u7624\u9776\u5411\u6297\u4f53\u7684\u6548\u679c\u3002\u6b64\u5916\uff0c\u4e5f\u8bc1\u660e\u4e86\u6297CD47\u7684\u5355\u6297\u53ef\u4ee5\u589e\u5f3a\u80bf\u7624\u7684\u9776\u5411\u6027\uff0c\u6297\u4f53\u901a\u8fc7\u89e6\u53d1\u5de8\u566c\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\uff0c\u4f7f\u80bf\u7624\u7ec6\u80de\u7684\u201c\u4e0d\u8981\u5403\u6211\u201d\u7684\u4fe1\u53f7\u4e2d\u65ad\u3002<\/p>\n

\u6240\u6709\u8fd9\u4e9b\u514d\u75ab\u8c03\u8282\u6297\u4f53\u76ee\u524d\u90fd\u5728\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5355\u72ec\u6216\u8054\u5408\u4f7f\u7528\uff0c\u7279\u522b\u662f\u4e0e\u80bf\u7624\u9776\u5411\u6297\u4f53\u4e00\u8d77\u6d4b\u8bd5\u3002\u8fd9\u79cd\u5feb\u901f\u7684\u4e34\u5e8a\u8f6c\u5316\u5c06\u4fc3\u4f7f\u8fd9\u4e9b\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u6709\u6548\u6027\u5728\u77ed\u65f6\u95f4\u5185\u5f97\u5230\u8bc4\u4f30\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncol<\/span>ab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/section>\n

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\u6765\u6e90 |<\/span>Oncoimmunology: A Practical Guide <\/span><\/section>\n
for Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 | Aur\u00e9lien Marabelle<\/span><\/section>\n
\u7ffb\u8bd1 | \u5f90\u66fc\u65af \u6f58\u541b\u541b \u674e\u5b89\u742a<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u8d75\u6db5<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u5218\u7389\u5a07 \u4f55\u4e3d\u5a1c<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
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\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
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