{"id":4884,"date":"2023-04-10T22:03:47","date_gmt":"2023-04-10T14:03:47","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/10\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac19%e7%ab%a0%ef%bc%9apd1%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e6%b2%bb%e7%96%97%e9%bb%91%e8%89%b2%e7%b4%a0%e7%98%a4%ef%bc%9a%e4%bb%8e-2\/"},"modified":"2023-04-10T22:03:47","modified_gmt":"2023-04-10T14:03:47","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac19%e7%ab%a0%ef%bc%9apd1%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e6%b2%bb%e7%96%97%e9%bb%91%e8%89%b2%e7%b4%a0%e7%98%a4%ef%bc%9a%e4%bb%8e-2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/10\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac19%e7%ab%a0%ef%bc%9apd1%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e6%b2%bb%e7%96%97%e9%bb%91%e8%89%b2%e7%b4%a0%e7%98%a4%ef%bc%9a%e4%bb%8e-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c19\u7ae0\uff1aPD1\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\uff1a\u4ece\u5355\u4e00\u7597\u6cd5\u5230\u8054\u5408\u7597\u6cd5\uff08\u4e0b\uff09"},"content":{"rendered":"
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<\/p>\n<\/section>\n<\/section>\n

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19.7 Pembrolizumab(\u6d3e\u59c6\u5355\u6297)<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2014\u5e749\u6708\uff0cFDA\u6279\u51c6\u6d3e\u59c6\u5355\u6297\uff08\u4ee5\u524d\u79f0\u4e3aMK3475\u6216\u5170\u535a\u5229\u73e0\u5355\u6297\uff09\u7528\u4e8e\u665a\u671f\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u30022015\u5e747\u6708\uff0cEMA\u4ee5\u4e0b\u9762\u4e09\u9879\u8bd5\u9a8c\u4e3a\u4f9d\u636e\uff0c\u6279\u51c6\u6d3e\u59c6\u5355\u6297\u8fd0\u7528\u4e8e\u665a\u671f\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\uff1a\u4e00\u671f\u8bd5\u9a8cKEYNOTE-001\u3001\u4e8c\u671f\u8bd5\u9a8cKEYNOTE-002\u548c\u4e09\u671f\u8bd5\u9a8cKEYNOTE-006\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728KEYNOTE-001\u8bd5\u9a8c\u4e2d\uff0c\u5206\u522b\u9009\u53d6\u6709\u548c\u6ca1\u6709\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff08\u5171135\u540d\uff09\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\uff0c\u4e09\u4e2a\u5206\u7ec4\u5242\u91cf\u5206\u522b\u4e3a\u6bcf2\u546810mg\/kg\uff08\u4f53\u91cd\uff09\u3001\u6bcf3\u546810mg\/kg\uff08\u4f53\u91cd\uff09\u3001\u6bcf3\u54682mg\/kg\uff08\u4f53\u91cd\uff09\u3002\u6240\u6709\u5242\u91cf\u7ec4\u4e2d\uff0c\u5168\u7fa4\u7ec4\u60a3\u8005\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a38%\uff0c\u603b\u4f53\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e2d\u4f4d\u6570>7\u4e2a\u6708\u3002<\/p>\n

\u5728\u968f\u673a\u6269\u5927\u961f\u5217\u8bd5\u9a8c\u4e2d\uff0c173\u4f8b\u5bf9\u4f0a\u5339\u5355\u6297\u548cBRAF\u6291\u5236\u5242(\u9488\u5bf9BRAF(V600)\u7a81\u53d8\u578b\u9ed1\u8272\u7d20\u7624)\u6cbb\u7597\u65e0\u6548\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a5\u53d7\u4e86\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\uff0c\u4e24\u4e2a\u5206\u7ec4\u5242\u91cf\u4e3a\u6bcf3\u54682mg\/kg\uff08\u4f53\u91cd\uff09\u3001\u6bcf3\u546810 mg\/kg\uff08\u4f53\u91cd\uff09\u3002\u4e24\u4e2a\u5242\u91cf\u7ec4\u7684ORR\u3001\u4e2d\u4f4dPFS\u548c\u4e00\u5e74\u751f\u5b58\u7387\u6ca1\u6709\u663e\u8457\u5dee\u5f02\u3002\u4f46\u662f\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u9879\u8bd5\u9a8c\u8868\u660e\uff0c\u63a5\u53d7\u4f0a\u5339\u5355\u6297\u9884\u6cbb\u7597\u7684\u60a3\u8005\u5bf9\u7eb3\u6b66\u5355\u6297\u6cbb\u7597\u4e5f\u4f1a\u4ea7\u751f\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728KEYNOTE-002\u968f\u673a\u8bd5\u9a8c\u4e2d\uff0c540\u540d\u60a3\u8005\u968f\u673a\u63a5\u53d7\u5242\u91cf\u4e3a2mg\/kg\uff08\u4f53\u91cd\uff09\u548c10mg\/kg\uff08\u4f53\u91cd\uff09\u7684\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u6216\u5316\u7597\u6cbb\u7597\u3002\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\u7684\u60a3\u8005\u5747\u63a5\u53d7\u8fc7\u4f0a\u5339\u5355\u6297\u548cBRAF\u6291\u5236\u5242(\u9488\u5bf9BRAF(V600)\u7a81\u53d8\u9ed1\u8272\u7d20\u7624)\u7684\u9884\u6cbb\u7597\u3002<\/p>\n

\u5728\u63a5\u53d7\u6cbb\u7597\u76849\u4e2a\u6708\u540e\uff0c\u4e0e\u63a5\u53d7\u5316\u7597\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u4e24\u79cd\u5242\u91cf\u4e2d\u4efb\u4f55\u4e00\u79cd\u5242\u91cf\u6cbb\u7597\u7684\u60a3\u8005\u7684PFS\u7387\u90fd\u663e\u8457\u9ad8\u4e8e\u63a5\u53d7\u5316\u7597\u6cbb\u7597\u7684\u60a3\u8005\uff1a\u63a5\u53d7\u6d3e\u59c6\u5355\u62972mg\/kg\uff08\u4f53\u91cd\uff09\u548c10 mg\/kg\uff08\u4f53\u91cd\uff09\u6cbb\u7597\u7684\u60a3\u8005\u7684PFS\u7387\u5206\u522b\u4e3a24%\u548c29%\uff0c\u800c\u63a5\u53d7\u5316\u7597\u7684\u60a3\u8005\u7684PFS\u7387\u4ec5\u4e3a8%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e09\u671f\u968f\u673a\u8bd5\u9a8cKeynote-006\u7684\u53c2\u8bd5\u8005\u4e3a834\u540d\u672a\u66fe\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5b83\u4eec\u5728\u8be5\u8bd5\u9a8c\u4e2d\u5c06\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6216\u4f0a\u5339\u5355\u6297\u6cbb\u7597(Table 19.1<\/span>)\u3002<\/p>\n

\u6d3e\u59c6\u5355\u6297\u4ee510 mg\/kg\uff08\u4f53\u91cd\uff09\u7684\u5242\u91cf\u5206\u522b\u6bcf2\u5468\u548c\u6bcf3\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u800c\u4f0a\u5339\u5355\u6297\u52064\u6b21\u7ed9\u836f\uff0c\u6bcf3\u54683 mg\/kg\uff08\u4f53\u91cd\uff09\u3002<\/p>\n

\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6bcf2\u5468\u548c3\u5468\u7ed9\u836f\u6cbb\u7597\u7684\u60a3\u8005\u76846\u4e2a\u6708PFS\u7387\u5206\u522b\u4e3a47.3%\u548c46.4%\uff0c\u800c\u63a5\u53d7\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e3a26.5%\u3002<\/p>\n

\u6d3e\u59c6\u5355\u6297\u6bcf2\u5468\u548c\u6bcf3\u5468\u7ed9\u836f\u7ec4\u7684\u60a3\u80051\u5e74\u751f\u5b58\u7387\u5206\u522b\u4e3a74.1%\u548c68.4%\uff0c\u800c\u4f0a\u5339\u5355\u6297\u7ec4\u4e3a58.2%\u3002\u6d3e\u59c6\u5355\u6297\u7684\u6709\u6548\u7387\u7ea6\u4e3a33%\uff0c\u800c\u4f0a\u5339\u5355\u6297\u5219\u4e3a12%\u3002<\/p>\n

\u4e24\u9879\u7814\u7a76\u4e2d\u671f\u5206\u6790\u663e\u793a\uff0c\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u589e\u52a0\uff0c\u8fd9\u9879\u7ed3\u679c\u5bfc\u81f4\u8be5\u7814\u7a76\u63d0\u524d\u7ec8\u6b62\uff0c\u968f\u540e\u63a5\u53d7\u4f0a\u5339\u5355\u6297\u7684\u60a3\u8005\u5c06\u4f7f\u7528\u6d3e\u59c6\u5355\u6297\u8fdb\u884c\u4ea4\u53c9\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6cbb\u7597\u6bd2\u6027\u65b9\u9762\uff0c\u4e0e\u4f0a\u5339\u5355\u6297(\u6216\u5316\u7597)\u76f8\u6bd4\uff0c\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u9891\u7387\u548c\u4e25\u91cd\u7a0b\u5ea6\u90fd\u8f83\u4f4e\u3002\u6700\u5e38\u89c1\u7684AE\u662f\u4e4f\u529b\u3001\u8179\u6cfb\u3001\u5185\u5206\u6ccc\u7d0a\u4e71\u3001\u76ae\u75b9\u548c\u7619\u75d2\u3002\u6b64\u5916\uff0c10-13%\u7684\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u60a3\u8005\uff08\u4ee5\u4e0d\u540c\u7684\u5468\u95f4\u9694\u7ed9\u836f\uff09\u548c19.9%\u63a5\u53d7\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f3\u7ea7\u62164\u7ea7\u836f\u7269\u76f8\u5173AE\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u800c\u8a00\u4e4b\uff0c\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u7684\u6709\u6548\u7387\u572830%\u523040%\u4e4b\u95f4\uff0c\u663e\u8457\u9ad8\u4e8e\u4f0a\u5339\u5355\u6297\u3002\u63a5\u53d7\u8fc7\u4f0a\u5339\u5355\u6297\u9884\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u518d\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\uff0c\u4f9d\u7136\u53d6\u5f97\u4e86\u826f\u597d\u7684\u6548\u679c\uff0c\u8fd9<\/span>\u52a0\u901f\u4e86FDA\u5bf9\u6d3e\u59c6\u5355\u6297\u4e34\u5e8a\u8fd0\u7528\u7684\u6279\u51c6\u3002<\/span><\/p>\n

\u7531\u4e8e\u5728\u5404\u9879\u8bd5\u9a8c\u4e2d\u53d1\u73b0\uff0c\u6d3e\u59c6\u5355\u6297\u4e0d\u540c\u5242\u91cf\u548c\u65f6\u95f4\u7684\u6cbb\u7597\u65b9\u6848\u5e76\u672a\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff0c<\/span>\u6240\u4ee5\u6279\u51c6\u4f7f\u7528\u7684\u5242\u91cf\u5b9a\u4e3a\u6bcf3\u5468\u7ed9\u836f2mg\/kg\uff08\u4f53\u91cd\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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19.8 \u6297PD-1\/\u6297CTLA-4\u8054\u5408\u7597\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7531\u4e8e\u4e0ePD-1\u548cCTLA-4\u53d7\u4f53\u7ed3\u5408\u7684\u914d\u4f53\u79cd\u7c7b\u4e0d\u540c\uff0c\u4e14\u914d\u4f53\u8868\u8fbe\u5728\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e0a<\/span>\u3002\u6240\u4ee5\uff0c\u4e3a\u4e86\u660e\u786e\u9488\u5bf9\u8fd9\u4e24\u4e2a\u68c0\u67e5\u70b9\u7684\u963b\u65ad\u6297\u4f53\u662f\u5426\u5177\u6709\u534f\u540c\u6216\u589e\u6548\u7684\u4f5c\u7528\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u5c55\u4e86\u8054\u5408\u8bd5\u9a8c\u3002<\/p>\n

\u5728CHECKMate-067\u8bd5\u9a8c\u4e2d\uff0c945\u540d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5728\u6ca1\u6709\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u63a5\u53d7\u4e86\u7eb3\u6b66\u5355\u6297\u548c\u4f0a\u5339\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\uff0c\u6216\u8005\u5355\u72ec\u63a5\u53d7\u7eb3\u6b66\u5355\u6297\u6216\u4f0a\u5339\u5355\u6297\u6cbb\u7597(\u968f\u673a\u53161\uff1a1\uff1a1)\u3002<\/p>\n

\u4e0e\u5355\u72ec\u4f7f\u7528\u7eb3\u6b66\u5355\u6297(PFS\uff0c6.9\u4e2a\u6708\uff1bORR\uff0c43.7%)\u6216\u4f0a\u5339\u5355\u6297(PFS\uff0c2.9\u4e2a\u6708\uff1bORR\uff0c19.0%)\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u7684PFS(11.5\u4e2a\u6708)\u548cORR(57.6%)\u660e\u663e\u66f4\u9ad8\u3002<\/p>\n

\u5728\u63a5\u53d7\u7eb3\u6b66\u5355\u6297\/\u4f0a\u5339\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c11.5%\u7684\u60a3\u8005\u7684\u75c7\u72b6\u5f97\u5230\u4e86\u5b8c\u5168\u7f13\u89e3\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5728\u5355\u72ec\u63a5\u53d7\u7eb3\u6b66\u5355\u6297\u6216\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5206\u522b\u53ea\u67098.9%\u548c2.2%\u7684\u60a3\u8005\u75c7\u72b6\u5f97\u5230\u4e86\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n

\u4f7f\u7528\u8054\u5408\u7597\u6cd5\u6cbb\u7597\u60a3\u8005\u7684\u6b7b\u4ea1\u6216\u80bf\u7624\u8fdb\u5c55\u98ce\u9669\uff0c\u8f83\u5355\u72ec\u4f7f\u7528\u4f0a\u5339\u5355\u6297\u7684\u60a3\u8005\u964d\u4f4e\u4e8658%\u3002<\/p>\n

\u8054\u5408\u6cbb\u7597\u7ec4\u867d\u7136\u5177\u6709\u66f4\u597d\u7684\u7597\u6548\uff0c\u4f46\u6211\u4eec\u4e0d\u80fd\u5ffd\u89c6\u5b83\u5e26\u6765\u7684\u4e25\u91cd\u6bd2\u526f\u4f5c\u7528\uff1a\u63a5\u53d7<\/span>\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670955%\u7684\u60a3\u8005\u53d1\u751f\u4e863\u7ea7\u548c4\u7ea7\u7684AE\u3002\u800c\u5355\u72ec\u63a5\u53d7\u7eb3\u6b66\u5355\u6297\u548c\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u5206\u522b\u53ea\u670916.3%\u548c27.3%\u7684\u60a3\u8005\u4f1a\u51fa\u73b03\u7ea7\u548c4\u7ea7\u7684AE\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5bf9PD-L1\u9634\u6027\u7684\u80bf\u7624\u60a3\u8005(\u901a\u8fc7\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u786e\u5b9a)\u6765\u8bf4\uff0c\u4e0e\u7eb3\u6b66\u5355\u6297\u5355\u836f\u6cbb\u7597\u76f8\u6bd4\uff0c\u7eb3\u6b66\u5355\u6297\/\u4f0a\u5339\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u6709\u6548\u7387\u66f4\u9ad8\uff0c\u800c\u5728PD-L1\u9633\u6027\u80bf\u7624\u60a3\u8005\u5219\u6ca1\u6709\u89c2\u5bdf\u5230\u8fd9\u79cd\u5dee\u5f02\u3002<\/p>\n

\u57fa\u4e8e\u8fd9\u4e00\u7ed3\u679c\uff0c\u7eb3\u6b66\u5355\u6297\/\u4f0a\u5339\u5355\u6297\u8054\u5408\u7597\u6cd5\u4e8e2016\u5e74\u88abFDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u60a3\u6709PD-L1\u9634\u6027\u80bf\u7624\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002\u800c\u5728\u6b27\u6d32\uff0c\u4e0d\u8bbaPD-L1\u7684\u8868\u8fbe\u5982\u4f55\uff0c\u90fd\u53ef\u4ee5\u88ab\u5141\u8bb8\u4f7f\u7528\u8be5\u8054\u5408\u7597\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u603b\u800c\u8a00\u4e4b\uff0c<\/span>\u6297PD-1\u548c\u6297PD-1\/CTLA-4\u8054\u5408\u7597\u6cd5\u5728\u7279\u5b9a\u7684\u60a3\u8005\u4e9a\u7ec4<\/span>\u4e2d\u53ef\u4ee5\u8bf1\u5bfc\u663e\u8457\u7684\u4e34\u5e8a\u53cd\u5e94\u3002\u4f46\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u5927\u591a\u6570\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5177\u6709\u539f\u53d1\u6027\u7684\u8010\u836f\u6027\u3002\u540c\u65f6\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4f7f\u7528\u540e\u671f\uff0c\u673a\u4f53\u5bf9\u836f\u7269\u51fa\u73b0\u7684\u7ee7\u53d1\u6027\u8010\u836f\u4e5f\u662f\u4e00\u4e2a\u9700\u8981\u6ce8\u610f\u7684\u95ee\u9898\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

19.9 \u4e0e\u6297PD-1\u6cbb\u7597\u5e94\u7b54<\/span>\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e3a\u4e86\u786e\u5b9a\u6700\u6709\u53ef\u80fd\u4ece\u6297PD-1\u6cbb\u7597\u4e2d\u53d7\u76ca\u7684\u60a3\u8005\u7fa4\u4f53\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u7ecf\u8fc7\u9884\u5904\u7406\u7684\u6d3b\u68c0\u91c7\u6837\u8fdb\u884c\u4e86\u5927\u91cf\u7b5b\u9009<\/span>\uff0c\u4ee5\u5bfb\u627e\u53ef\u7528\u4e8e\u9884\u6d4b\u60a3\u8005\u5bf9\u6297PD-1\u7597\u6cd5\u6709\u6548\u6027\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4f46\u662f\u76ee\u524d\u4ecd\u672a\u627e\u5230\u3002<\/p>\n

\u867d\u7136\u5728\u51e0\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u90fd\u5df2\u7ecf\u660e\u786e\u4e86\u53ef\u4ee5\u901a\u8fc7\u514d\u75ab\u7ec4\u5316\u6807\u8bb0\u80bf\u7624\u6807\u672c\u662f\u5426\u662fPD-L1\u9633\u6027\uff0c\u4f46\u662f\u7531\u4e8e\u4f7f\u7528\u7684\u67d3\u8272\u6297\u4f53\u53ca\u5224\u5b9aPD-L1\u9633\u6027\u7684\u4e34\u754c\u503c\u5c1a\u672a\u7edf\u4e00\uff0c\u5404\u8bd5\u9a8c\u7684\u7ed3\u679c\u51e0\u4e4e\u4e0d\u5177\u6709\u53ef\u6bd4\u6027\u3002<\/p>\n

\u6b64\u5916\uff0c\u867d\u7136PD-1\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u5bf9PD-L1\u9633\u6027\u80bf\u7624\u60a3\u8005\u6709\u6548\u7387\u66f4\u9ad8\uff0c\u4f46\u6297-PD1\u7597\u6cd5\u5bf9PD-L1\u9634\u6027\u80bf\u7624\u60a3\u8005\u4e5f\u6709\u6548\u679c\u3002<\/p>\n

\u540c\u65f6\uff0c\u4e0eCD8+<\/sup>T\u7ec6\u80de\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u88ab\u91cd\u65b0\u6fc0\u6d3b\u5e76\u542f\u52a8\u4e34\u5e8a\u53cd\u5e94\u7684\u7279\u6027<\/span>\u4e00\u81f4\u7684\u662f\uff0c\u76ee\u524d\u5df2\u7ecf\u660e\u786e\u4e86\u80bf\u7624\u5b9e\u8d28\u5185\u548c\u75c5\u53d8\u8fb9\u7f18\u5b58\u5728\u7684\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de\u4e0e\u673a\u4f53\u6297PD-1\u6cbb\u7597\u7684\u5e94\u7b54\u6709\u5173\uff0c\u9488\u5bf9\u65b0\u6297\u539f\u7684\u7279\u5f02\u6027T\u7ec6\u80de\u5728\u5176\u4e2d\u53d1\u6325\u7740\u6700\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

\u6839\u636e\u8fd9\u4e00\u70b9\uff0c\u6211\u4eec\u53ef\u4ee5\u77e5\u9053\uff0c\u51b3\u5b9a\u65b0\u6297\u539f\u6570\u91cf\u7684\u9ed1\u8272\u7d20\u7624\u7a81\u53d8\u8d1f\u8377\u4e0e\u60a3\u8005\u5bf9\u6297CTLA-4\u6cbb\u7597\u7684\u5e94\u7b54\u6709\u5173\uff0c<\/span>\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd9\u79cd\u5173\u8054\u5c1a\u672a\u89c1\u4e8e\u6297PD-1\u6cbb\u7597\u3002<\/span><\/p>\n

\u4e3a\u66f4\u597d\u9884\u6d4b\u60a3\u8005\u5bf9\u6297PD-1\u6cbb\u7597\u662f\u5426\u51fa\u73b0\u5e94\u7b54\uff0c\u6211\u4eec\u9700\u8981\u8054\u5408\u591a\u4e2a\u751f\u7269\u6807\u8bb0\u7269\uff0c\u5c06\u5b83\u4eec\u4f5c\u4e3a\u5171\u540c\u7684\u5224\u65ad\u6307\u6807\u3002\u672a\u6765\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c06\u7ee7\u7eed\u6df1\u5165\u7814\u7a76\uff0c\u660e\u786e\u66f4\u591a\u53ef\u6709\u6548\u7528\u4e8e\u9884\u6d4b\u60a3\u8005\u5bf9\u6297PD-1\u6cbb\u7597\u5e94\u7b54\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

19.10 \u5bf9\u6cbb\u7597\u7684\u8010\u836f\u6027<\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e3a\u9610\u660e\u4ecb\u5bfc\u673a\u4f53\u5bf9PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u8010\u836f\u673a\u5236<\/span>\uff0c\u4e34\u5e8a\u533b\u751f\u548c\u79d1\u5b66\u5bb6\u5c55\u5f00\u4e86\u5bc6\u5207\u5408\u4f5c\u3002\u76ee\u524d\u53d1\u8868\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u8010\u836f\u673a\u5236\u662f\u591a\u65b9\u9762\u7684\u3002<\/p>\n

\u6b63\u5982\u6700\u8fd1\u51e0\u7bc7\u7efc\u8ff0\u4e2d\u603b\u7ed3\u7684\u90a3\u6837\uff0c\u53ef\u4ee5\u5927\u81f4\u5c06\u8fd9\u4e9b\u673a\u5236\u5206\u4e3a\uff1a\u80bf\u7624\u5185\u5728\u56e0\u7d20\u548c\u80bf\u7624\u5916\u5728\u56e0\u7d20\u3002<\/p>\n

\u540e\u8005\u5305\u62ec\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4e0d\u540c\u514d\u75ab\u8c03\u8282\u7ec6\u80de\uff08\u8c03\u8282\u6027T\u7ec6\u80de\u3001\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\u3001\u4e2d\u6027\u7c92\u7ec6\u80de) \u7684\u6d3b\u6027\uff0c\u8fd9\u4e9b\u514d\u75ab\u8c03\u8282\u7ec6\u80de\u5728\u672c\u4e66\u7684\u5176\u4ed6\u7ae0\u8282\u4e2d\u90fd\u6709\u4ecb\u7ecd\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5c06\u91cd\u70b9\u4ecb\u7ecd\u9ed1\u8272\u7d20\u7624\u7684\u5185\u5728\u56e0\u7d20\uff0c\u8fd9\u4e9b\u56e0\u7d20\u5df2\u88ab\u786e\u5b9a\u4e0e\u673a\u4f53\u6297PD-1\u6cbb\u7597\u7684\u514d\u75ab\u8010\u53d7\u76f8\u5173\uff0c\u5305\u62ec\u673a\u4f53\u7684\u539f\u53d1\u6027\u8010\u836f\u548c\u7ee7\u53d1\u6027\u8010\u836f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u9ed1\u8272\u7d20\u7624\u7684\u9057\u4f20\u5177\u6709\u4e0d\u7a33\u5b9a\u6027\uff0c\u4e00\u65b9\u9762\u53ef\u4ea7\u751f\u6cbb\u7597\u76f8\u5173\u7684\u65b0\u6297\u539f\uff0c\u53e6\u4e00\u65b9\u9762\u4e5f\u4ea7\u751f\u4e86\u53ef\u4ee5\u62b5\u6297\u6cbb\u7597\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u4f7f\u5176\u53d1\u751f\u514b\u9686\u6027\u589e\u751f\uff0c\u4fc3\u8fdb\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u8fdb\u5316\u4ee5\u9003\u907f\u514d\u75ab\u6740\u4f24<\/span>\u3002<\/p>\n

\u6240\u4ee5\uff0c\u6211\u4eec\u80fd\u4ece\u4e00\u540d\u6700\u521d\u5bf9\u6297PD-1\u6297\u4f53\u6cbb\u7597\u6709\u53cd\u5e94\uff0c\u4f46\u540e\u671f\u51fa\u73b0\u8fdb\u5c55\u6027\u75c5\u53d8\u7684\u60a3\u8005\u4e2d<\/span>\u5206\u79bb\u51faMHC-I\u7c7b\u5206\u5b50\u9634\u6027\u7684\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\uff0c\u800c\u8fd9\u4e9b\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u9057\u4f20\u83b7\u5f97\u4e86B2M\u7f3a\u9677\u3002<\/p>\n

\u7531\u4e8eB2M\u662f\u6240\u6709HLA I\/\u6297\u539f\u590d\u5408\u7269\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u6240\u4ee5B2M\u7f3a\u9677\u7684\u7ec6\u80de\u4f1a\u5f62\u6210\u4e0d\u53ef\u9006\u7684HLA I\u7c7b\u9634\u6027\u8868\u578b\uff0c\u9003\u9038T\u7ec6\u80de\u653b\u51fb\u3002<\/p>\n

\u8be5\u73b0\u8c61\u5728\u4ee5\u5f80\u7684\u9ed1\u8272\u7d20\u7624\u7814\u7a76\u4e2d\u4e5f\u88ab\u62a5\u9053\u8fc7\uff0c\u8fd9\u8868\u660e\u9ed1\u8272\u7d20\u7624\u5bf9T\u7ec6\u80de\u7684\u5b8c\u5168\u62b5\u6297\u662f\u4ecb\u5bfc\u673a\u4f53\u963b\u65adPD-1\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u8010\u836f\u673a\u5236\u4e4b\u4e00\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u6700\u8fd1\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u963b\u65ad\u5e72\u6270\u7d20\u03b3\u4fe1\u53f7\u7684\u7a81\u53d8\uff0c\u4e0e\u673a\u4f53\u5bf9\u6297PD-1\u6cbb\u7597\u7684\u539f\u53d1\u6027\u8010\u836f\u4e0e\u7ee7\u53d1\u6027\u8010\u836f\u76f8\u5173\u3002\u5e72\u6270\u7d20\u03b3\u7531\u901a\u8fc7TCR\u9014\u5f84\u6fc0\u6d3b\u7684T\u7ec6\u80de\u91ca\u653e\uff0c\u53ef\u4ee5\u589e\u5f3a\u514d\u75ab\u7597\u6cd5\u7684\u7597\u6548\u3002<\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e0a\u5b58\u5728JAK1\u548cJAK2\u57fa\u56e0\u7684\u529f\u80fd\u7f3a\u9677\uff0c\u800c\u8fd9\u4e24\u4e2a\u57fa\u56e0\u662f\u5e72\u6270\u7d20\u03b3\u4fe1\u53f7\u901a\u8def\u7684\u7ec4\u6210\u90e8\u5206\u3002\u6240\u4ee5\uff0c\u8be5\u57fa\u56e0\u529f\u80fd\u7f3a\u9677\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u4e0d\u518d\u5bf9\u5e72\u6270\u7d20\u03b3\u7684\u6297\u589e\u6b96\u548c\u4fc3\u51cb\u4ea1\u7684\u4f5c\u7528\u654f\u611f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u6709\u8da3\u7684\u662f\uff0c\u975e\u57fa\u56e0\u7ec4\u673a\u5236\u4f3c\u4e4e\u5728\u673a\u4f53\u5bf9\u6297PD-1\u6cbb\u7597<\/span>\u7684\u8010\u53d7\u4e2d\u53d1\u6325\u4e86\u4f5c\u7528\u3002\u7814\u7a76\u8868\u660e\uff0c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e2d\u7684\u7279\u5b9a\u8f6c\u5f55\u7279\u5f81\u53ef\u4ee5\u5b9a\u4e49\u4e00\u79cd\u53bb\u5206\u5316\u7684\u80bf\u7624\u8868\u578b\uff0c\u8be5\u8868\u578b\u4f1a\u5bfc\u81f4<\/span>\u6297\u539f\u5448\u9012\u4e0b\u8c03\u548cT\u7ec6\u80de\u6d78\u6da6\u7a0b\u5ea6\u964d\u4f4e\u3002\u8fd9\u8868\u660e\u7531\u4e8e\u5176\u8868\u578b\u7684\u53ef\u5851\u6027\uff0c\u9ed1\u8272\u7d20\u7624\u5177\u6709\u53ef\u9006\u7684\u8010\u836f\u72b6\u6001\u3002\u76ee\u524d\uff0c\u5173\u4e8e\u66f4\u591a\u4e0e\u673a\u4f53\u5bf9\u6297PD-1\u6cbb\u7597\u8010\u836f\u6027\u660e\u786e\u76f8\u5173\u7684\u5176\u4ed6\u673a\u5236\u548c\u8868\u578b\u7684\u8bd5\u9a8c\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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19.11 \u524d\u666f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1\u4ee5\u53caPD-1\u8054\u5408CTLA-4\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u7684\u6279\u51c6\u4f7f\u7528\u662f\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u7684\u4e00\u4e2a\u91cc\u7a0b\u7891\uff0c\u6539\u53d8\u4e86\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u7684\u73b0\u72b6\uff0c\u5e76\u5728\u665a\u671f\u60a3\u8005\u4e2d\u6210\u529f\u83b7\u5f97\u4e86\u663e\u8457\u7684\u4e34\u5e8a\u6548\u679c\u3002\u73b0\u5728\u5c1a\u9700\u540e\u7eed\u5927\u578b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u4ee5\u786e\u5b9a\u901a\u8fc7\u8fd9\u4e9b\u6cbb\u7597\uff0c\u60a3\u8005\u53ef\u4ee5\u83b7\u5f97\u7684\u603b\u4f53\u7684\u957f\u671f\u4e34\u5e8a\u6536\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 19.3<\/span> \u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u76f8\u5173\u7684\u4e34\u5e8a\u53cd\u5e94\u548c\u7ec6\u80de\u6bd2\u6027\u3002\u57fa\u4e8ePD-1\u7684\u6cbb\u7597\u663e\u793a\u51fa\u6700\u9ad8\u7684\u4e34\u5e8a\u5e94\u7b54\u7387\u3002\u6297PD-1\/\u6297CTLA-4\u8054\u5408\u6cbb\u7597\u53ef\u663e\u8457\u589e\u52a0\u6cbb\u7597\u76f8\u5173\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\u3002\u5728\u672a\u6765\uff0cPD-1\u68c0\u67e5\u70b9\u963b\u65ad\u4e0e\u5176\u4ed6\u836f\u7269(X)\u7684\u7ed3\u5408\u53ef\u80fd\u4f1a\u5728\u4f4e\u7ec6\u80de\u6bd2\u6027\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0\u9ad8\u5e94\u7b54\u7387\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9884\u8ba1\u6709\u76f8\u5f53\u4e00\u90e8\u5206\u60a3\u8005\u5c06\u6210\u4e3a\u514d\u75ab\u7597\u6cd5\u7684\u957f\u671f\u53d7\u76ca\u8005\u3002\u4f46\u5927\u591a\u6570\u60a3\u8005\u4ecd\u7136\u5bf9PD-1\u548cPD-1\u8054\u5408CTLA-4\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u5177\u6709\u539f\u53d1\u6027\u8010\u836f\u3002<\/p>\n

\u6b64\u5916\uff0c\u7531\u4e8e\u6297PD-1\/CTLA-4\u8054\u5408\u6cbb\u7597\u5177\u6709\u9ad8\u6bd2\u526f\u4f5c\u7528\uff0c\u6240\u4ee5\u4ecd\u9700\u63a2\u7d22\u7597\u6548\u9ad8\u3001\u6bd2\u526f\u4f5c\u7528\u4f4e\u7684\u65b0\u8054\u5408\u7597\u6cd5\uff0c\u76ee\u524d\u7814\u7a76\u4eba\u5458\u6b63\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u5bf9\u65b0\u7684\u8054\u5408\u7597\u6cd5\u8fdb\u884c\u5927\u91cf\u7b5b\u9009(Fig. 19.3<\/span>)\u3002<\/p>\n

\u5176\u4e2d\uff0cBRAF\/MEK\u6291\u5236\u5242\u4e0ePD-1\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u7684\u8054\u5408\u8fd0\u7528\u53d6\u5f97\u4e86\u4e0d\u9519\u7684\u8bd5\u9a8c\u7ed3\u679c\u3002\u7ea650%\u60a3\u6709BRAF(V600)\u7a81\u53d8\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a5\u53d7BRAF\u548cMEK\u6291\u5236\u5242\u7684\u8054\u5408\u6cbb\u7597\uff0c\u60a3\u8005\u5bf9\u8fd9\u4e9b\u6291\u5236\u5242\u7684\u53cd\u5e94\u4e0e\u5305\u62ecCD8+<\/sup>T\u7ec6\u80de\u5728\u5185\u7684\u4e0d\u540c\u514d\u75ab\u7ec6\u80de\u5728\u75c5\u53d8\u90e8\u4f4d\u7684\u6d78\u6da6\u7a0b\u5ea6\u76f8\u5173\u3002<\/p>\n

\u8fd9\u4e00\u7ed3\u8bba\u4e3a\u6291\u5236\u5242\u6cbb\u7597\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u76f8\u7ed3\u5408\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002\u76ee\u524d\uff0c\u7814\u7a76BRAF\/MEK\u6291\u5236\u5242\u8054\u5408PD-1\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u7597\u6cd5\u7684\u9996\u6279\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u542f\u52a8(https:\/\/ClinicaTrials.GOV\uff1bNCT02130466)\u3002<\/p>\n

\u9664\u4e86PD-1\u548cCTLA-4\uff0c\u88ab\u6fc0\u6d3b\u7684\u80bf\u7624\u53cd\u5e94\u6027CD8+<\/sup>T\u7ec6\u80de\u8fd8\u8868\u8fbe\u5176\u4ed6\u514d\u75ab\u68c0\u67e5\u70b9\uff0c\u5305\u62ecLAG3\u3001TIM3\u548cTIGIT\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u5e72\u6270\u7d20\u03b3\u6700\u8fd1\u88ab\u8bc1\u660e\u53ef\u4ee5\u4fc3\u8fdb\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e0a\u4e0d\u540c\u514d\u75ab\u68c0\u67e5\u70b9\u914d\u4f53\u7684\u8868\u8fbe\u3002\u7531\u4e8e\u8fd9\u4e9b\u53d7\u4f53\u4f3c\u4e4e\u5728\u63a7\u5236T\u7ec6\u80de\u6d3b\u6027\u65b9\u9762\u5177\u6709\u4e00\u5b9a\u529f\u80fd\uff0c\u6240\u4ee5\u76ee\u524d\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\u5b83\u4eec\u4e0e\u6297PD-1\u6297\u4f53\u8054\u5408\u6cbb\u7597\u7684\u53ef\u80fd\u6027(https:\/\/ClinicaTrials.gov; NCT01968109: \u6297PD-1\u8054\u5408\u6297LAG3\u6297\u4f53)\u3002<\/p>\n

\u8fd8\u6709\u4e00\u79cd\u8054\u5408\u6cbb\u7597\u7684\u65b9\u6848\u662f\u5c06\u6297PD-1\u6cbb\u7597\u4e0e\u7624\u5185\u6ce8\u5c04\u6eb6\u7624\u75c5\u6bd2(T-VEC)\u76f8\u7ed3\u5408\uff0c\u8bf1\u5bfc\u4e13\u804c\u6297\u539f\u63d0\u5448\u7ec6\u80de\u6444\u53d6\u6297\u539f\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3aT\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u6709\u5173\u5176\u4ed6\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u4e34\u5e8a\u7814\u7a76\u73b0\u72b6\uff0c\u53ef\u4ee5\u5728 https:\/\/ClinicaTrials.gov  \u4e0a\u8fdb\u884c\u67e5\u770b\u3002\u4e00\u4e9b\u8bd5\u9a8c\u53ef\u80fd\u5f88\u5feb\u5c31\u80fd\u5f97\u5230\u521d\u6b65\u7ed3\u679c\uff0c\u4f46\u4ecd\u9700\u8981\u66f4\u591a\u65f6\u95f4\u6765\u4f18\u5316\u8054\u5408\u6cbb\u7597\u7684\u7ed9\u836f\u95f4\u9694\u548c\u5242\u91cf\u3002<\/p>\n

\u603b\u4f53\u6765\u8bf4\uff0c\u5176\u4e2d\u4e00\u4e9b\u8bd5\u9a8c\u53ef\u80fd\u4f1a\u5bf9\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u4ea7\u751f\u5f71\u54cd\uff0c\u5e76\u4e3a\u4e0d\u540c\u7684\u60a3\u8005\u4e9a\u7fa4\u63d0\u4f9b\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/span><\/span>
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\u2014<\/span> <\/span>T<\/span>H<\/span>E<\/span> <\/span> <\/span>E<\/span>N<\/span>D<\/span> <\/span>\u2014<\/span><\/span><\/p>\n


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\u6765<\/span>\u6e90<\/span> <\/span>|<\/span> <\/span>O<\/span>n<\/span>c<\/span>o<\/span>i<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>l<\/span>o<\/span>g<\/span>y<\/span>:<\/span> <\/span>A<\/span> <\/span>P<\/span>r<\/span>a<\/span>c<\/span>t<\/span>i<\/span>c<\/span>a<\/span>l<\/span> <\/span>G<\/span>u<\/span>i<\/span>d<\/span>e<\/span> <\/span><\/span><\/section>\n
f<\/span>o<\/span>r<\/span> <\/span>C<\/span>a<\/span>n<\/span>c<\/span>e<\/span>r<\/span> <\/span>I<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>t<\/span>h<\/span>e<\/span>r<\/span>a<\/span>p<\/span>y<\/span><\/span><\/section>\n
\u4f5c<\/span>\u8005<\/span> <\/span>|<\/span> <\/span><\/span><\/span>Annette Paschen and Dirk Schadendorf<\/span><\/span><\/section>\n
\u7ffb<\/span>\u8bd1<\/span> <\/span>|<\/span> <\/span>\u9648\u8389\u8679 \u6e29\u946b \u90d1\u68a6\u6021 \u7ae0\u9707 \u5e94\u6b63<\/span><\/span><\/span><\/span><\/section>\n
\u7f16<\/span>\u8f91<\/span>\u6392<\/span>\u7248<\/span> <\/span>| \u6e29\u946b \u5415\u601d\u8d24<\/span><\/span><\/span><\/span><\/span><\/span><\/section>\n
\u521d<\/span>\u5ba1<\/span> <\/span>|<\/span> \u5218\u7389\u5a07<\/span> \u80e1\u73ca<\/span><\/span><\/span><\/section>\n
\u7ec8<\/span>\u5ba1<\/span> <\/span>|<\/span> \u738b<\/span>\u5764<\/span><\/span><\/span><\/span><\/section>\n
\uff08<\/span>\u8f6c<\/span>\u8f7d<\/span>\u8bf7<\/span>\u4fdd<\/span>\u7559<\/span>\u6b64<\/span>\u90e8<\/span>\u5206<\/span>\u5185<\/span>\u5bb9<\/span>\uff09<\/span><\/span><\/strong><\/section>\n


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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u5b66\u672f\u5bfc\u822a<\/strong><\/strong><\/p>\n

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\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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