{"id":4888,"date":"2023-04-12T15:17:56","date_gmt":"2023-04-12T07:17:56","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/12\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac20%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e6%8a%91%e5%88%b6%e5%9c%a8%e8%82%ba%e7%99%8c%e6%b2%bb%e7%96%97%e4%b8%ad\/"},"modified":"2023-04-12T15:17:56","modified_gmt":"2023-04-12T07:17:56","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac20%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e6%8a%91%e5%88%b6%e5%9c%a8%e8%82%ba%e7%99%8c%e6%b2%bb%e7%96%97%e4%b8%ad","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/12\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac20%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e6%8a%91%e5%88%b6%e5%9c%a8%e8%82%ba%e7%99%8c%e6%b2%bb%e7%96%97%e4%b8%ad\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c20\u7ae0\uff1a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5728\u80ba\u764c\u6cbb\u7597\u4e2d\u7684\u8fd0\u7528\uff08\u4e0a)"},"content":{"rendered":"
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<\/p>\n<\/section>\n<\/section>\n

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20.1 \u5f15\u8a00<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7f8e\u56fd\u4ee5\u53ca\u5168\u4e16\u754c\u8303\u56f4\u5185\uff0c\u80ba\u764c\u90fd\u662f\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u636e\u7f8e\u56fd\u764c\u75c7\u534f\u4f1a\u4f30\u8ba1\uff0c2016\u5e74\u670915.8\u4e07\u7f8e\u56fd\u4eba\u6b7b\u4e8e\u80ba\u764c\uff0c\u800c\u6839\u636e\u5168\u7403\u764c\u75c7\u6d41\u884c\u75c5\u5b66\u6570\u636e\u5e93\uff08GLOBOCAN\uff09\u7684\u8c03\u67e5\uff0c2012\u5e74\u5168\u7403\u5171\u6709160\u4e07\u4eba\u6b7b\u4e8e\u80ba\u764c\u3002<\/p>\n

\u5728\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u5927\u7ea687%\u7684\u60a3\u8005\u4e3a\u975e\u5c0f\u7ec6\u80de\u764c(NSCLC)\uff0c\u800c\u5927\u7ea613%\u7684\u60a3\u8005\u4e3a\u5c0f\u7ec6\u80de\u764c(SCLC)\u3002NSCLC\u53ef\u8fdb\u4e00\u6b65\u7ec6\u5206\u4e3a\u817a\u764c(ADC)\u3001\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\u764c(SQCC)\u548c\u5927\u7ec6\u80de\u764c(LC)\u3002\u5927\u591a\u6570NSCLC\u60a3\u8005\u4e00\u7ecf\u53d1\u73b0\u5373\u4e3a\u665a\u671f\uff0c\u57fa\u672c\u65e0\u6cd5\u6cbb\u6108\uff0c\u5e38\u91c7\u7528\u59d1\u606f\u7597\u6cd5\u6cbb\u7597\u3002<\/p>\n

\u9664\u4e86\u5c11\u6570\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u7a81\u53d8\u6216\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u6613\u4f4d\u7684\u7279\u5b9a\u60a3\u8005\u53ef\u4ee5\u4f7f\u7528\u916a\u6c28\u9178\u6fc0\u9176\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7684\u9776\u5411\u7597\u6cd5\u6cbb\u7597\u4ee5\u5916\uff0c\u5927\u591a\u6570\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u5e38\u89c4\u7597\u6cd5\u4f7f\u7528\u7684\u662f\u94c2\u7c7b\u53cc\u8054\u5316\u7597\u65b9\u6848\uff08\u4ee5\u94c2\u7c7b\u4e3a\u4e3b\u7684\u53cc\u836f\u8054\u5408\u5316\u7597\u65b9\u6848\uff09\u3002<\/p>\n

\u4e0e\u5355\u72ec\u4f7f\u7528\u5316\u7597\u836f\u7269\u76f8\u6bd4\uff0c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50(VEGF)\u6216EGFR\u7684\u5355\u514b\u9686\u6297\u4f53\u4e0e\u5316\u7597\u836f\u7269\u8054\u5408\u4f7f\u7528\u53ef\u83b7\u5f97\u66f4\u597d\u7684\u7597\u6548\uff0c\u56e0\u6b64VEGF\u4e0eEGFR\u7684\u5355\u6297\u5df2\u83b7\u6279\u51c6\u7528\u4e8e\u80ba\u764c\u7684\u6cbb\u7597\u3002<\/p>\n

\u5b9e\u9645\u4e0a\uff0c\u6240\u6709\u60a3\u8005\u5728\u4e00\u7ebf\u6cbb\u7597\u540e\u90fd\u4f1a\u51fa\u73b0\u80bf\u7624\u8fdb\u5c55\uff0c\u6807\u51c6\u7684\u4e8c\u7ebf\u6cbb\u7597\u65b9\u6848\u662f\u4f7f\u7528\u591a\u70ef\u7d2b\u6749\u9187\uff08docetaxel\uff09\uff0c\u4f46\u4f7f\u7528\u591a\u897f\u7d2b\u6749\u9187\u540e\uff0c\u60a3\u8005\u7684\u5ba2\u89c2\u7f13\u89e3\u7387(ORR)\u5c0f\u4e8e10%\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u4e0d\u52303\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f(OS)\u4e3a5.7-7.9\u4e2a\u6708\u3002<\/p>\n

\u867d\u7136\u9488\u5bf9VEGF\u53d7\u4f532\u80de\u5916\u7ed3\u6784\u57df\u7684\u96f7\u83ab\u82a6\u5355\u6297\uff08ramucirumab\uff09\u5df2\u88ab\u6279\u51c6\u4e0e\u591a\u70ef\u7d2b\u6749\u9187\uff08docetaxel\uff09\u8054\u5408\u5e94\u7528\u4e8e\u5df2\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u665a\u671fNSCLC\u60a3\u8005\uff0c\u4f46\u8fd9\u79cd\u8054\u5408\u6cbb\u7597\u7684\u76ca\u5904\u4ec5\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4e34\u5e8a\u6548\u679c\u5219\u6536\u6548\u751a\u5fae\uff0c\u60a3\u8005\u4e2d\u4f4dPFS\u4ece3\u4e2a\u6708\u589e\u52a0\u52304.5\u4e2a\u6708\uff0c\u4e2d\u4f4dOS\u4ec5\u4ece9.1\u4e2a\u6708\u589e\u52a0\u523010.5\u4e2a\u6708\u3002\u663e\u7136\uff0c\u6211\u4eec\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\u6765\u6539\u5584\u665a\u671fNSCLC\u60a3\u8005\u7684\u9884\u540e\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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20.2 \u963b\u65ad\u514d\u75ab\u68c0\u67e5\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u5e45\u5ea6\u548c\u8d28\u91cf\u7531\u5171\u523a\u6fc0\u548c\u5171\u6291\u5236\u4fe1\u53f7\u4e4b\u95f4\u7684\u5e73\u8861\u6765\u8c03\u8282\u3002\u5728\u6b63\u5e38\u7684\u751f\u7406\u6761\u4ef6\u4e0b\uff0c\u5171\u540c\u6291\u5236\u5206\u5b50\uff0c\u4e5f\u88ab\u79f0\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\uff0c\u7ef4\u6301\u7ec6\u80de\u514d\u75ab\u8010\u53d7\u4ee5\u9632\u6b62\u81ea\u8eab\u514d\u75ab\uff0c\u5e76\u4fdd\u62a4\u7ec4\u7ec7\u5728\u5bf9\u611f\u67d3\u53d1\u751f\u7684\u514d\u75ab\u53cd\u5e94\u4e2d\u4e0d\u53d7\u5230\u9644\u5e26\u635f\u5bb3\u3002<\/p>\n

\u7136\u800c\uff0c\u764c\u7ec6\u80de\u53ef\u80fd\u4f1a\u5229\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u4ea7\u751f\u7684\u514d\u75ab\u8010\u53d7\u6548\u5e94\u8fdb\u884c\u514d\u75ab\u9003\u9038\u3002\u5176\u4e2d\uff0c\u8d77\u5173\u952e\u4f5c\u7528\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u5305\u62ec\u7ec6\u80de\u6bd2\u6027\u6dcb\u5df4\u7ec6\u80de\u6297\u539f4(CTLA-4)\u548c\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1(PD-1)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1\uff0c\u4e5f\u88ab\u79f0\u4e3aCD279\uff0c\u662f\u4e00\u4e2a\u7531288\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684I\u578b\u8de8\u819c\u86cb\u767d\u53d7\u4f53\uff0c\u7531\u4e00\u4e2a\u8d85\u5bb6\u65cf\u7ed3\u6784\u57df\u86cb\u767d\u3001\u4e00\u4e2a\u753120\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u57fa\u67c4\u3001\u4e00\u4e2a\u5305\u542b\u514d\u75ab\u53d7\u4f53\u916a\u6c28\u9178\u6291\u5236\u57fa\u5e8f(ITIM)\u548c\u514d\u75ab\u53d7\u4f53\u916a\u6c28\u9178\u5f00\u5173\u57fa\u5e8f(ITSM)\u7684\u80de\u5185\u916a\u6c28\u9178\u57fa\u5e8f\u7684\u7ed3\u6784\u57df\u7ec4\u6210\u3002<\/p>\n

\u867d\u7136PD-1\u4e0d\u5728\u9759\u6b62\u671f\u7684T\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u4f46\u5b83\u53ef\u80fd\u4f1a\u88ab\u8bf1\u5bfc\u8868\u8fbe\u3002\u901a\u5e38\u5728T\u7ec6\u80de\u6fc0\u6d3b\u540e\u768424\u5c0f\u65f6\u5185PD-1\u4f1a\u51fa\u73b0\uff0c\u4e00\u65e6\u6297\u539f\u88ab\u6e05\u9664\uff0cPD-1\u7684\u8868\u8fbe\u91cf\u5c31\u4f1a\u4e0b\u964d\u3002\u5728\u6162\u6027\u611f\u67d3\u6216\u764c\u75c7\u671f\u95f4\uff0c\u7531\u4e8eT\u7ec6\u80de\u6301\u7eed\u53d7\u5230\u6297\u539f\u7684\u523a\u6fc0\uff0c\u56e0\u6b64PD-1\u7684\u8868\u8fbe\u4f1a\u6301\u7eed\u5347\u9ad8\uff0c\u5e76\u4f7fT\u7ec6\u80de\u5206\u5316\u4e43\u81f3\u8fdb\u5165\u8017\u5c3d\u6216\u65e0\u80fd\u72b6\u6001\u3002<\/p>\n

PD-1\u7684\u4e24\u4e2a\u914d\u4f53\u5206\u522b\u662f\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f53-1(PD-L1)\uff0c\u4e5f\u79f0\u4e3aCD274\u6216B7-H1\uff1b\u4ee5\u53ca\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f53-2(PD-L2)\uff0c\u4e5f\u79f0\u4e3aCD273\u6216B7-DC(Fig.20.1<\/span>)\u3002PD-L1\u5728\u9020\u8840\u7ec6\u80de\u548c\u975e\u9020\u8840\u7ec6\u80de\u4e2d\u90fd\u6709\u8868\u8fbe\uff0c\u800cPD-L2\u7684\u8868\u8fbe\u8f83\u6709\u9650\uff0c\u4e3b\u8981\u5728\u6811\u7a81\u72b6\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u4e0a\u8868\u8fbe\u3002<\/p>\n

\u9664\u4e86PD-1\u5916\uff0c\u8fd9\u4e24\u79cd\u914d\u4f53\u8fd8\u53ef\u4ee5\u7ed3\u5408\u53e6\u4e00\u79cd\u5206\u5b50\uff0c\u5176\u4e2dPD-L1\u53ef\u4ee5\u4e0eT\u7ec6\u80de\u4e0a\u7684CD80(B7.1) \u7ed3\u5408\uff0cPD-L2\u7ed3\u5408\u6392\u65a5\u6027\u5bfc\u5411\u5206\u5b50b(RGMb)\u3002<\/p>\n

PD-1\u4e0ePD-L1\u6216PD-L2\u7684\u7ed3\u5408\u5bfc\u81f4PD-1\u4e0aITIM\u548cITSM\u916a\u6c28\u9178\u57fa\u5e8f\u53d1\u751f\u78f7\u9178\u5316\uff0c\u5e76\u62db\u52df\u7edc\u6c28\u9178\u78f7\u9178\u9176SHP-2\uff0c\u51cf\u5c11T\u7ec6\u80de\u53d7\u4f53(TCR)\u4fe1\u53f7\u5206\u5b50\u7684\u78f7\u9178\u5316\u3002\u4e0e\u914d\u4f53\u7ed3\u5408\u540e\uff0cPD-1\u6fc0\u6d3b\u7684\u4fe1\u53f7\u8fd8\u53ef\u4ee5\u6291\u5236PI3K\u548cMAPK\u901a\u8def\u3001\u6291\u5236T\u7ec6\u80de\u589e\u6b96\u3001\u51cf\u5c11\u7ec6\u80de\u56e0\u5b50\u548c\u7ec6\u80de\u6bd2\u6027\u6548\u5e94\u5206\u5b50\u7684\u4ea7\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n


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Fig.20.1 <\/span>PD-1\u7684\u914d\u4f53\u4e3aPD-L1\u548cPD-L2\uff0cPD-L1\u548cPD-L2\u4e5f\u53ef\u4e0eB7.1\u548cRGMb\u7ed3\u5408\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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20.3 \u5355\u836f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u521d\u6b65\u7814\u7a76<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7eb3\u6b66\u5355\u6297\uff08nivolumab\uff09\u662f\u4e00\u79cd\u6297PD-1\u7684IgG4\u5355\u6297\uff0c\u4ee5\u524d\u79f0\u4e3aMDX-1106\u6216BMS-936558\u3002\u5728\u9996\u6b21\u4f7f\u7528\u7eb3\u6b66\u5355\u6297\u8fdb\u884c\u7684\u4eba\u7c7bI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c39\u540d\u665a\u671f\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u80be\u7ec6\u80de\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u6216\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u63a5\u53d7\u4e860.3\u30011\u30013\u548c10 mg\/kg\u7684 4\u4e2a\u9012\u589e\u7684\u5355\u6b21\u5355\u5242\u91cf\u961f\u5217\u6cbb\u7597\uff0c\u8fd939\u540d\u60a3\u8005\u5747\u60a3\u6709\u8fdb\u884c\u6027\u548c\u96be\u6cbb\u6027\u75be\u75c5\uff0c\u65e2\u5f80\u6cbb\u7597\u4e2d\u4f7f\u7528\u836f\u7269\u79cd\u7c7b\u7684\u4e2d\u4f4d\u6570\u4e3a4\u79cd\u3002<\/p>\n

\u672c\u6b21\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u6807\u662f\u68c0\u6d4b\u5355\u836f\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5bf9\u4e8e\u80bf\u7624\u6ca1\u6709\u7ee7\u7eed\u8fdb\u5c55\u6216\u6ca1\u6709\u53d1\u751f3\u7ea7\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\uff0c\u5728\u5b9e\u9a8c\u5f00\u59cb\u7b2c12\u5468\u548c\u7b2c16\u5468\u7ed9\u4e0e\u989d\u5916\u5242\u91cf\uff0c\u5e76\u53ef\u57283\u4e2a\u6708\u65f6\u91cd\u590d\u6cbb\u7597\u3002<\/p>\n

\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u7eb3\u6b66\u5355\u6297\u6cbb\u7597\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u5355\u6b21\u7ed9\u836f\u540e\u65e0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u5176\u4e2d12\u540d\u60a3\u8005\u5728\u521d\u59cb\u5242\u91cf\u75c5\u60c5\u7a33\u5b9a\u6216\u80bf\u7624\u6d88\u9000\u540e\u63a5\u53d7\u4e86\u591a\u6b21\u7eb3\u6b66\u5355\u6297\u6cbb\u7597\u3002<\/p>\n

\u5728\u6ca1\u6709\u4e0d\u53ef\u63a5\u53d7\u7684\u4e0d\u826f\u4e8b\u4ef6\u3001\u5b8c\u5168\u7f13\u89e3(CR)\u6216\u8fdb\u5c55\u6027\u75be\u75c5(PD)\u7684\u60c5\u51b5\u4e0b\uff0c\u8be5\u7814\u7a76\u968f\u540e\u8fdb\u884c\u4e86\u957f\u8fbe\u4e24\u5e74\u7684\u5242\u91cf\u6269\u5c55\u961f\u5217\u8bd5\u9a8c\uff0c\u5bf9\u60a3\u6709\u76f8\u540c\u6076\u6027\u80bf\u7624\u7684\u60a3\u8005\u6bcf\u4e24\u5468\u4f7f\u75281\u30013\u621610 mg\/kg\u7684\u7eb3\u6b66\u5355\u6297\u3002<\/p>\n

\u6709\u5173NSCLC\u961f\u5217\u7814\u7a76\u7684\u6700\u65b0\u62a5\u544a\u5305\u62ec129\u540d\u60a3\u8005\uff0c\u5176\u4e2d70\u540d(54.3%)\u66fe\u63a5\u53d7\u8fc7\u4e09\u79cd\u4ee5\u4e0a\u7684\u7cfb\u7edf\u65b9\u6848\u6cbb\u7597\u3002\u8be5\u7597\u6cd5\u8010\u53d7\u6027\u826f\u597d\uff0c<\/span>\u53ea\u670914%\u7684\u60a3\u8005\u53d1\u751f\u4e0e\u6cbb\u7597\u76f8\u5173\u76843\u7ea7\u62164\u7ea7\u4e0d\u826f\u4e8b\u4ef6(TES)\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u4ecd\u67093\u4f8b\u60a3\u8005\u6b7b\u4e8e\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u80ba\u708e\u3002<\/p>\n

\u4e0d\u8bba\u662f\u9cde\u72b6\u7ec6\u80de\u764c\u8fd8\u662f\u975e\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u7eb3\u6b66\u5355\u6297\u6240\u6709\u5242\u91cf\u7684\u5ba2\u89c2\u7f13\u89e3\u7387(ORR)\u4e3a17%\u3002\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a2.3\u4e2a\u6708\uff0c22%\u60a3\u80051\u5e74\u5185\u80bf\u7624\u65e0\u8fdb\u5c55\uff0c9%\u7684\u60a3\u80052\u5e74\u5185\u80bf\u7624\u65e0\u8fdb\u5c55\u3002\u7eb3\u6b66\u5355\u6297\u6cbb\u7597\u540e\uff0c\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e2d\u4f4d\u6570\u4e3a9.9\u4e2a\u6708\u300142%\u7684\u60a3\u8005\u53ef\u751f\u5b581\u5e74\u300124%\u7684\u60a3\u8005\u53ef\u751f\u5b582\u5e74\u300118%\u7684\u60a3\u8005\u53ef\u751f\u5b583\u5e74\u3002<\/p>\n

\u5176\u4e2d\u7eb3\u6b66\u5355\u6297\u6cbb\u7597\u5242\u91cf\u4e3a0.3 mg\/kg\u7684\u7ec4\u7684\u9884\u540e\u6700\u597d\uff0c\u4ed6\u4eec\u7684ORR\u4e3a24.3%\uff0c\u4e2d\u4f4dOS\u4e3a14.9\u4e2a\u6708\uff0c56%\u7684\u60a3\u8005\u53ef\u751f\u5b581\u5e74\u300142%\u7684\u60a3\u8005\u53ef\u751f\u5b582\u5e74\u300127%\u7684\u60a3\u8005\u53ef\u751f\u5b583\u5e74\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

Keynote-001\u7814\u7a76\u5c06495\u540dNSCLC\u60a3\u8005\u8fdb\u884c\u5206\u7ec4\uff0c\u5206\u522b\u7ed9\u4e88\u4e0d\u540c\u5242\u91cf\u7684\u5e15\u666e\u5229\u73e0\u5355\u6297(pembrolizumab)\u8fdb\u884c\u6cbb\u7597\uff0c\u5e15\u666e\u5229\u73e0\u5355\u6297\u66fe\u88ab\u79f0\u4e3aMK-3475\uff0c\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u7684\u6297PD-1\u7684IgG4\u5355\u6297\u3002\u8be5\u6297\u4f53\u6cbb\u7597\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u4ec5\u670947\u4f8b(9.5%)\u60a3\u8005\u51fa\u73b03\u7ea7\u6216\u66f4\u9ad8\u7684\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6(TAEs)\u3002\u60a3\u8005\u7684ORR\u4e3a19.4%\uff0c\u4e2d\u4f4dPFS\u4e3a3.7\u4e2a\u6708\uff0cOS\u4e3a12\u4e2a\u6708\u3002<\/p>\n

\u5728182\u540d\u8bd5\u836f\u7ec4\u7684\u60a3\u8005\u4e2d\uff0c\u5b9e\u9a8c\u4eba\u5458\u901a\u8fc7\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u6807\u8bb0PD-L1\u819c\u67d3\u8272\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u8ba1\u7b97PD-L1\u9633\u6027\u7ec6\u80de\u767e\u5206\u6bd4\u3002\u901a\u8fc7\u7b5b\u9009\uff0c\u9009\u62e9\u51fa\u81f3\u5c1150%\u7684\u80bf\u7624\u7ec6\u80de\u90fd\u6709PD-L1\u8868\u8fbe\u7684\u60a3\u8005\u3002\u7b5b\u9009\u51fa\u7684\u8fd9\u4e9b\u9ad8\u8868\u8fbePD-L1\u7684\u60a3\u8005\u7684ORR\u3001\u4e2d\u4f4dPFS\u548cOS\u5206\u522b\u4e3a45.2%\u30016.3\u4e2a\u6708\uff0c\u672a\u8fbe\u5230\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0d\u540c\u6d4b\u8bd5\u65b9\u6848\u4e4b\u95f4\u7684\u7597\u6548\u6ca1\u6709\u5dee\u5f02\u3002<\/p>\n

\u5728824\u4f8b\u53d7\u8bd5\u8005\u4e2d\uff0c23.2%\u7684\u60a3\u8005PD-L1\u9633\u6027\u7ec6\u80de\u5360\u6bd4\u4e3a50%\u6216\u4ee5\u4e0a\u300137.6%\u7684\u60a3\u8005\u4e3a1~49%\u300139.1%\u7684\u60a3\u8005PD-L1\u9633\u6027\u7ec6\u80de\u5360\u6bd4<1%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u5bf9\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08\u4eba\u6e90\u6027\u7684\u6297PD-L1\u7684IgG\u5355\u6297\uff09\u7684\u521d\u6b65\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5bf9277\u4f8b\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u8fdb\u884c\u4e86\u4ee53\u5468\u4e3a\u4e00\u5468\u671f\u4e14\u4e0d\u65ad\u589e\u52a0\u5242\u91cf\u7684\u9759\u8109\u8f93\u6ce8\uff0c\u5b9e\u9a8c\u517116\u4e2a\u5468\u671f\uff0c\u4e3a\u671f1\u5e74\u300253\u4f8bNSCLC\u60a3\u8005\u7684ORR\u548c24\u5468PFS\u5206\u522b\u4e3a23%\u548c45%\u3002<\/p>\n

\u9884\u5904\u7406\u6807\u672c\u4e2dPD-L1\u7684\u8868\u8fbe\u4e0e\u6cbb\u7597\u6548\u679c\u6709\u76f8\u5173\u6027\uff0c\u5bf9NSCLC\u800c\u8a00\uff0cPD-L1\u4e0e\u6cbb\u7597\u6548\u679c\u7684\u76f8\u5173\u6027\u5728\u80bf\u7624\u6d78\u6da6\u6027\u514d\u75ab\u7ec6\u80de(ICs)\u4e2d\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4f46\u5728\u80bf\u7624\u7ec6\u80de(TCs)\u4e2d\u8fd9\u79cd\u5173\u8054\u5219\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\u3002<\/p>\n

\u5927\u591a\u6570\u80bf\u7624\u8fdb\u5c55\u7684\u60a3\u8005\u5728\u80bf\u7624\u7ec6\u80de\u6216\u514d\u75ab\u7ec6\u80de\u4e2d\u6ca1\u6709PD-L1\u8868\u8fbe\uff0c\u751f\u957f\u4e2d\u7684\u80bf\u7624\u5177\u6709\u514d\u75ab\u5ffd\u89c6\u7684\u6a21\u5f0f\uff0c\u51e0\u4e4e\u6ca1\u6709\u80bf\u7624\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\uff0c\u514d\u75ab\u53cd\u5e94\u65e0\u6548\uff0c\u6d78\u6da6\u7684\u514d\u75ab\u7ec6\u80de\u8868\u8fbe\u975e\u5e38\u5c11\u7684PD-L1\u6216\u6ca1\u6709\u8868\u8fbe\uff0c\u6216\u8005\u88ab\u6392\u9664\u5728\u80bf\u7624\u5916\u7f18\u5468\u56f4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

20.4 \u65e2\u5f80\u6cbb\u7597\u60a3\u8005\u7684\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u665a\u671fNSCLC\u60a3\u8005\u4e2d\uff0c\u6297PD-1\u6216PD-L1\u7684\u5355\u5242\u5355\u6297\u7684\u826f\u597d\u6548\u679c\u5438\u5f15\u4e86\u8bb8\u591a\u79d1\u5b66\u5bb6\u5229\u7528\u5176\u8fdb\u884c\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u4e2d\u4ee5\u6bcf3\u5468\u4f7f\u7528\u4e00\u6b2175 mg\/m2<\/sup>\u7684\u591a\u70ef\u7d2b\u6749\u9187\u4f5c\u4e3a\u5bf9\u7167\u3002\u6240\u6709\u7814\u7a76\u5747\u4ee5\u6539\u5584OS\u4e3a\u4e3b\u8981\u89c2\u5bdf\u7ec8\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728CHECKMate-017\u8bd5\u9a8c\u4e2d\uff0c272\u540d\u63a5\u53d7\u8fc7\u4e00\u7ebf\u836f\u7269\u6cbb\u7597\u7684\u665a\u671f\u9cde\u72b6\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u88ab\u968f\u673a\u5206\u6210\u4e24\u7ec4\uff0c\u5b9e\u9a8c\u7ec4\u6bcf2\u5468\u4f7f\u7528\u4e00\u6b213 mg\/kg\u7684\u7eb3\u6b66\u5355\u6297 \uff0c\u5bf9\u7167\u7ec4\u5219\u4f7f\u7528\u591a\u70ef\u7d2b\u6749\u9187\u3002\u5176\u4e2d\u7eb3\u6b66\u5355\u6297\u7684\u8010\u53d7\u6027\u6bd4\u591a\u70ef\u7d2b\u6749\u9187\u66f4\u597d\uff0c\u8bd5\u9a8c\u4e2d\u672a\u53d1\u73b0\u7eb3\u6b66\u5355\u6297\u5e26\u6765\u65b0\u7684\u5b89\u5168\u9690\u60a3\u3002<\/p>\n

\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u591a\u70ef\u7d2b\u6749\u9187\u76f8\u6bd4\uff0c\u63a5\u53d7\u7eb3\u6b66\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005ORR(20% vs 8%\uff0cP<\/em>=0.008)\u3001\u4e2d\u4f4dPFS(3.5 vs 2.8\u4e2a\u6708\uff0c\u98ce\u9669\u6bd4[HR]0.62\uff0cP<\/em><0.001)\u548c\u4e2d\u4f4dOS(9.2 vs 6.0\u4e2a\u6708\uff0cHR 0.59\uff0cP<\/em><0.001)\u589e\u52a0\u3002\u5e76\u4e14\u7eb3\u6b66\u5355\u6297\u5bf9PFS\u548cOS\u7684\u76ca\u5904\u4e0d\u4f9d\u8d56\u4e8e\u80bf\u7624\u7ec6\u80de\u4e2dPD-L1\u7684\u8868\u8fbe\u3002<\/p>\n

CHECKMate-057\u5b9e\u9a8c\u5177\u6709\u7c7b\u4f3c\u7684\u8bbe\u8ba1\uff0c\u5c06582\u540d\u665a\u671fNSCLC\u60a3\u8005\u968f\u673a\u5206\u4e3a\u63a5\u53d7\u6807\u51c6\u5242\u91cf\u7684\u7eb3\u6b66\u5355\u6297\u6216\u591a\u70ef\u7d2b\u6749\u9187\u6cbb\u7597\u7684\u4e24\u7ec4\u3002\u540c\u65f6\u6240\u6709\u60a3\u8005\u90fd\u9700\u8981\u8054\u5408\u94c2\u7c7b\u836f\u7269\u8fdb\u884c\u5316\u7597\uff0c\u800c\u90a3\u4e9b\u5df2\u77e5\u6709EGFR\u7a81\u53d8\u6216ALK\u6613\u4f4d\u7684\u60a3\u8005\u5141\u8bb8\u989d\u5916\u4f7f\u7528\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u3002<\/p>\n

\u4e0eCHECKMate-017\u8bd5\u9a8c\u76f8\u4f3c\uff0c\u7eb3\u6b66\u5355\u6297\u7684\u8010\u53d7\u6027\u6bd4\u591a\u70ef\u7d2b\u6749\u9187\u66f4\u597d\uff0c\u5e76\u53ef\u589e\u52a0ORR\u6c34\u5e73(19% vs 12%\uff0cP<\/em>=0.02)\u3002\u4e0d\u8fc7\uff0c\u8be5\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u591a\u70ef\u7d2b\u6749\u9187\u7ec4\u5728\u4e2d\u4f4dPFS\u7684\u6539\u5584\u4e2d(2.3 vs 4.2\u4e2a\u6708\uff1bHR 0.92\uff0cP<\/em>=0.39)\u5360\u4f18\u52bf\uff0c\u800c\u7eb3\u6b66\u5355\u6297\u7ec4\u57281\u5e74PFS\u4e0a\u66f4\u5360\u4f18\u52bf (19% vs 8%)\u3002\u4f7f\u7528\u7eb3\u6b66\u5355\u6297\u7ec4\u7684\u4e2d\u4f4dOS (12.2 vs 9.4\u4e2a\u6708\uff1bHR 0.73\uff0cP<\/em>=0.002)\u548c1\u5e74OS(51% vs 39%)\u5747\u597d\u4e8e\u591a\u70ef\u7d2b\u6749\u9187\u7ec4\u3002<\/p>\n

\u8fd9\u4e24\u9879\u7814\u7a76\u7684\u7ed3\u679c\u4fc3\u4f7f\u7eb3\u6b66\u5355\u6297\u88ab\u6279\u51c6\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u9cde\u72b6\u7ec6\u80de\u548c\u975e\u9cde\u72b6\u7ec6\u80de\u7ec4\u7ec7\u5b66\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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Keynote-010\u5b9e\u9a8c\u968f\u673a\u9009\u62e9\u4e861034\u540d\u66fe\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684PD-L1\u9633\u6027\u7684NSCLC\u80bf\u7624\u60a3\u8005\uff0c\u4ed6\u4eec\u88ab\u5206\u4e3a\u6bcf3\u5468\u670d\u7528\u591a\u70ef\u7d2b\u6749\u9187\u30012 mg\/kg\u6d3e\u59c6\u5355\u6297\u621610 mg\/kg\u6d3e\u59c6\u5355\u6297\u4e09\u7ec4\u3002<\/p>\n

\u7ed3\u679c\u663e\u793a\uff0c\u6d3e\u59c6\u5355\u6297\u7684\u8010\u53d7\u6027\u597d\u4e8e\u591a\u70ef\u7d2b\u6749\u9187\u3002\u4e24\u7ec4\u4e0d\u540c\u5242\u91cf\u7684\u6d3e\u59c6\u5355\u6297\u7ec4\u7684OS\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u56e0\u6b64\u7814\u7a76\u4eba\u5458\u9009\u62e92 mg\/kg\u5242\u91cf\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n

\u4e0e\u591a\u70ef\u7d2b\u6749\u9187\u76f8\u6bd4\uff0c2 mg\/kg\u6d3e\u59c6\u5355\u6297\u53ef\u589e\u52a0ORR(18% vs 9%\uff0cP<\/em>=0.0005)\u548c\u6539\u5584\u4e2d\u4f4dOS(12.7 vs 8.5\u4e2a\u6708\uff0cHR 0.71\uff0cP<\/em>=0.0008)\uff0c\u4f46\u5bf9\u4e2d\u4f4dPFS(3.9 vs 4\u4e2a\u6708\uff0cHR 0.88\uff0cP<\/em>=0.07)\u6ca1\u6709\u592a\u5927\u5f71\u54cd\u3002<\/p>\n

2 mg\/kg\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u5bf9PD-L1\u9633\u6027\u7ec6\u80de\u6bd4\u4f8b\u9ad8\u7684\u4eba\u7fa4\u6548\u679c\u66f4\u597d\u3002\u4e0ePD-L1\u8bc4\u5206\u5c0f\u4e8e50%\u7684\u60a3\u8005\u76f8\u6bd4\uff0cPD-L1\u9633\u6027\u7ec6\u80de\u5360\u6bd450%\u4ee5\u4e0a\u7684\u60a3\u8005\u8868\u73b0\u4e3a\u66f4\u9ad8\u7684\u4e2d\u4f4dPFS(5 vs 4.1\u4e2a\u6708\uff0cHR 0.59\uff0cP<\/em>=0.0001)\uff1b\u66f4\u9ad8\u7684ORR(30% vs 8%,P<\/em> < 0.0001); \u66f4\u591a\u7684\u4e2d\u4f4dOS(14.9 vs 8.2\u4e2a\u6708\uff0cHR 0.59\uff0cP<\/em>=0.0002)\u3002<\/p>\n

\u5728\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u9664\u4e86EGFR\u7a81\u53d8\u60a3\u8005\u5916\uff0c\u5728\u6240\u6709\u53d8\u91cf\u7ec4\u4e2d\u6d3e\u59c6\u5355\u6297\u5bf9OS\u7684\u4f5c\u7528\u90fd\u5927\u4e8e\u591a\u70ef\u7d2b\u6749\u9187(HR 0.88\uff0c95%\u53ef\u4fe1\u533a\u95f4[CI]0.45-1.70)\uff0c\u5176\u4e2d\u8fd8\u53d1\u73b0\u4e86PFS\u6076\u5316\u7684\u8d8b\u52bf(HR 1.79\uff0c95%CI 0.94-3.42)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Poplar\u662f\u4e00\u98792\u671f\u968f\u673a\u8bd5\u9a8c\uff0c287\u540d\u66fe\u7ecf\u63a5\u53d7\u8fc7\u4e00\u79cd\u94c2\u7c7b\u5316\u7597\u7684\u665a\u671fNSCLC\u60a3\u8005\u88ab\u968f\u673a\u5206\u6210\u4e24\u7ec4\uff0c\u7b2c\u4e00\u7ec4\u6bcf3\u5468\u4f7f\u7528\u6807\u51c6\u5242\u91cf\u7684\u591a\u70ef\u7d2b\u6749\u9187\uff0c\u7b2c\u4e8c\u7ec4\u6bcf\u4e09\u5468\u4f7f\u75281200 mg\u7684\u963f\u66ff\u5229\u73e0\u5355\u6297\u3002\u6839\u636ePD-L1\u7684\u8868\u8fbe\u5bf9TCs\u548cICs\u8fdb\u884c\u8bc4\u5206\u3002<\/p>\n

\u963f\u66ff\u5229\u73e0\u5355\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e14\u6ca1\u6709\u65b0\u7684\u5b89\u5168\u9690\u60a3\u3002\u5c3d\u7ba1\u8bd5\u9a8c\u8bc1\u660e\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e0eORR(15% vs 15%)\u6216\u4e2d\u4f4dPFS(2.7 vs 3\u4e2a\u6708\uff0cHR 0.94\uff1b95%CI 0.72-1.23)\u7684\u5dee\u5f02\u65e0\u5173\uff0c\u4f46\u5728\u8bd5\u9a8c\u7ec4\u4e2d\uff0c\u60a3\u8005\u7684OS\u53d1\u751f\u663e\u8457\u6539\u5584(12.6 vs 9.7\u4e2a\u6708\uff0cHR 0.73\uff0cP=0.04)\u3002\u4e0d\u8fc7\u53ea\u6709\u5728\u81f3\u5c11\u8fbe\u5230PD-L1\u8bc4\u5206\u7b49\u7ea7TC1\u6216IC1\u7ea7\u7684\u60a3\u8005\u4e2d\u624d\u80fd\u89c2\u5bdf\u5230\u963f\u66ff\u5229\u73e0\u5355\u6297\u5bf9\u60a3\u8005OS\u7684\u6539\u5584\u3002<\/p>\n

OAK\u662f\u4e00\u98793\u671f\u7814\u7a76\uff0c\u5b83\u968f\u673a\u9009\u62e9\u4e861125\u540d\u66fe\u63a5\u53d7\u8fc7\u4e00\u7ebf\u6216\u4e8c\u7ebf\u5316\u7597\u7684\u665a\u671fNSCLC\u60a3\u8005\uff0c\u670d\u75281200 mg\u963f\u66ff\u5229\u73e0\u5355\u6297\u6216\u591a\u70ef\u7d2b\u6749\u9187\u3002\u4e0e\u591a\u70ef\u7d2b\u6749\u9187\u76f8\u6bd4\uff0c\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u8010\u53d7\u6027\u66f4\u597d\uff0c3\u7ea7\u62164\u7ea7\u4e0d\u826f\u53cd\u5e94\u66f4\u5c11(34% vs 54%)\u3002<\/p>\n

\u7814\u7a76\u8868\u660e\uff0c\u5728\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\u4e2d\uff0c\u963f\u66ff\u5229\u73e0\u5355\u6297\u5bf9\u4e8e\u4f20\u7edf\u6cbb\u7597\u65b9\u6848\u800c\u8a00\uff0c\u4f7f\u7528\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u4eba\u7fa4\u4e0d\u4f1a\u5e26\u6765ORR\u6216\u4e2d\u4f4dPFS(2.8 vs 4\u4e2a\u6708\uff0cHR 0.95\uff1b95%CI 0.82-0.10)\u7684\u6539\u5584\u3002\u4f46\u662f\u53ef\u4ee5\u4f7f\u5176\u4e2d\u4f4dOS\u663e\u8457\u5ef6\u957f(13.8 vs 9.6\u4e2a\u6708\uff0cHR 0.73)\u3002P=0.0003)\u3002\u65e0\u8bbaPD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u60a3\u8005\u7684OS\u5747\u6709\u6539\u5584\u3002TC0\u548cIC0(12.6 vs 8.9\u4e2a\u6708\uff0cHR 0.75\uff0cP=0.02)\uff0cTC1-3\u6216IC1-3(15.7 vs 10.3\u4e2a\u6708\uff0cHR 0.74\uff0cP=0.0001)\uff0cTC3\u6216IC3(20.5 vs 8.9\u4e2a\u6708\uff0cHR 0.41\uff0cP<0.05)\u3002\u9664EGFR\u7a81\u53d8\u7684\u60a3\u8005\u5916\uff0c\u6240\u6709\u7ec4\u7684\u4e2d\u4f4d\u6570OS\u90fd\u8868\u660e\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u66f4\u6709\u6548(HR 1.24\uff1b95%CI 0.71-2.18)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014<\/span> <\/span>T<\/span>H<\/span>E<\/span> <\/span> <\/span>E<\/span>N<\/span>D<\/span> <\/span>\u2014<\/span><\/span><\/p>\n


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\u6765<\/span>\u6e90<\/span> <\/span>|<\/span> <\/span>O<\/span>n<\/span>c<\/span>o<\/span>i<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>l<\/span>o<\/span>g<\/span>y<\/span>:<\/span> <\/span>A<\/span> <\/span>P<\/span>r<\/span>a<\/span>c<\/span>t<\/span>i<\/span>c<\/span>a<\/span>l<\/span> <\/span>G<\/span>u<\/span>i<\/span>d<\/span>e<\/span> <\/span><\/span><\/section>\n
f<\/span>o<\/span>r<\/span> <\/span>C<\/span>a<\/span>n<\/span>c<\/span>e<\/span>r<\/span> <\/span>I<\/span>m<\/span>m<\/span>u<\/span>n<\/span>o<\/span>t<\/span>h<\/span>e<\/span>r<\/span>a<\/span>p<\/span>y<\/span><\/span><\/section>\n
\u4f5c<\/span>\u8005<\/span> <\/span>|<\/span> <\/span><\/span><\/span>Daniel Morgensztern and Roy S. Herbst<\/span><\/span><\/section>\n
\u521d\u7a3f\u7ffb<\/span>\u8bd1<\/span> <\/span>|<\/span> <\/span>\u6e29\u946b \u8d75\u6db5 \u7ae0\u9707 \u6797\u5b50\u7545 \u7f57\u4f73\u4f73<\/span><\/span><\/span><\/span><\/section>\n
\u7f16<\/span>\u8f91<\/span>\u6392<\/span>\u7248<\/span> <\/span>| \u6f58\u541b\u541b \u675c\u8f7b\u677e<\/span><\/span><\/span><\/span><\/span><\/span><\/section>\n
\u5ba1\u6838\u4fee\u6539 <\/span>|<\/span> \u738b\u5764<\/span> \u80e1\u73ca<\/span><\/span><\/section>\n
\uff08<\/span>\u8f6c<\/span>\u8f7d<\/span>\u8bf7<\/span>\u4fdd<\/span>\u7559<\/span>\u6b64<\/span>\u90e8<\/span>\u5206<\/span>\u5185<\/span>\u5bb9<\/span>\uff09<\/span><\/span><\/strong><\/section>\n


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\u2589  \u5f3a\u70c8\u63a8\u8350<\/strong><\/strong><\/p>\n

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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u516c\u4f17\u53f7\u4e0a\u7684\u5f80\u671f\u6587\u7ae0\u540c\u6b65\u53d1\u5e03\u81f3\u5bf9\u5e94\u7f51\u7ad9OncoLab\u5b9e\u9a8c\u5ba4\u3002<\/p>\n

\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u5b66\u672f\u5bfc\u822a<\/strong><\/strong><\/p>\n

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\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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