{"id":4937,"date":"2023-05-04T07:01:28","date_gmt":"2023-05-03T23:01:28","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/05\/04\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%8c%ef%bc%9a%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%be%ae\/"},"modified":"2023-05-04T07:01:28","modified_gmt":"2023-05-03T23:01:28","slug":"2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%8c%ef%bc%9a%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%be%ae","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/05\/04\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%8c%ef%bc%9a%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%be%ae\/","title":{"rendered":"2023\u5e74\u5ea6\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\u4e8c\uff1a\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u53ca\u5176\u5ef6\u4f38"},"content":{"rendered":"
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1.\u901a\u8fc7\u9776\u5411galectin-\u7cd6\u57fa\u76f8\u4e92\u4f5c\u7528\u91cd\u7f16\u7a0b\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883<\/strong><\/p>\n<\/section>\n

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Gabriel A. Rabinovich – \u751f\u7269\u5b66\u548c\u5b9e\u9a8c\u533b\u5b66\u7814\u7a76\u6240\uff0c\u963f\u6839\u5ef7\u5e03\u5b9c\u8bfa\u65af\u827e\u5229\u65af\u5e02<\/strong><\/p>\n<\/section>\n

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Gabriel Rabinovich\u5728\u201c\u6765\u81ea\u8d64\u9053\u4ee5\u5357\u7684\u751c\u871c\u5192\u9669\u201d\u4e2d\u5c55\u793a\u4e86\u4ed6\u5bf9Galectin-1\uff08Gal-1\uff09\u7684\u51e0\u5341\u5e74\u7814\u7a76\u3002Gal-1\u5728\u5927\u591a\u6570\u4eba\u7c7b\u80bf\u7624\u4e2d\u4e0a\u8c03\uff0c\u5e76\u4e0e\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002\u5b83\u7531\u764c\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u4e00\u4e9b\u514d\u75ab\u7ec6\u80de\u8868\u8fbe\u548c\u5206\u6ccc\uff0c\u5e76\u5177\u6709\u4e24\u4e2a\u7ed3\u5408\u7cd6\u57faN-\u4e59\u9170-\u4e73\u7cd6\u80fa\uff08LacNac\uff09\u7684\u4f4d\u70b9\uff0cLacNac\u5b58\u5728\u4e8e\u590d\u6742\u7684N-\u7cd6\u57fa\u548c\u6838\u5fc31\/2 O-\u7cd6\u57fa\u4e2d\u3002Gal-1\u4f5c\u4e3a\u4e00\u4e2a\u7cd6\u57fa\u68c0\u67e5\u70b9\uff0c\u4fc3\u8fdb\u80bf\u7624\u514d\u75ab\u9003\u9038\u548c\u8840\u7ba1\u751f\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Gal-1-\u7cd6\u57fa\u76f8\u4e92\u4f5c\u7528\u901a\u8fc7\u8bf1\u5bfcTh1\u3001Th17\u548cCD8+ T\u7ec6\u80de\u7684\u9009\u62e9\u6027\u6b7b\u4ea1\uff0c\u540c\u65f6\u4fdd\u7559\u643a\u5e26\u03b1(2,6)-\u553e\u6db2\u9178\u5316\u7ec6\u80de\u8868\u9762\u7cd6\u86cb\u767d\u7684Th2\u548cTreg\u7ec6\u80de\uff0c\u901a\u8fc7IL-27\u548cIL-10\u9a71\u52a8\u7684\u56de\u8def\u4fc3\u8fdb\u8010\u53d7\u6027\u6811\u7a81\u72b6\u7ec6\u80de\u548cM2\u5de8\u566c\u7ec6\u80de\u6781\u5316\uff0c\u4ee5\u53ca\u5728\u9ad3\u6837\u6291\u5236\u7ec6\u80de\uff08MDSCs\uff09\u4e2d\u6fc0\u6d3b\u514d\u75ab\u6291\u5236\u548c\u4fc3\u8840\u7ba1\u751f\u6210\u7684\u7a0b\u5e8f\u3002Gal-1\u8fd8\u5c06\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u548c\u8840\u7ba1\u751f\u6210\u8054\u7cfb\u8d77\u6765\u3002\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u764c\u7ec6\u80de\u5206\u6cccGal-1\uff0c\u5b83\u53ef\u4ee5\u4e0e\u5185\u76ae\u7ec6\u80de\u4e0a\u7684VEGFR2\u7ed3\u5408\uff0c\u6a21\u4effVEGF\uff0c\u5e76\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728AVAST-M 3\u671f\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7\u8d1d\u4f10\u5355\u6297\uff08\u6297VEGF mAb\uff09\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u5faa\u73afGal-1\u6c34\u5e73\u5347\u9ad8\u4e0e\u590d\u53d1\u548c\u6b7b\u4ea1\u98ce\u9669\u589e\u52a0\u76f8\u5173\uff0c\u4e14\u975e\u5e94\u7b54\u60a3\u8005\u7684\u8840\u6d46\u6837\u672c\u53ef\u4ee5\u901a\u8fc7Gal-1-VEGFR2\u9014\u5f84\u91cd\u65b0\u7f16\u7a0b\u5185\u76ae\u7ec6\u80de\u3002\u603b\u4e4b\uff0cGal-1\u548c\u5176\u4ed6galectin\u7f51\u7edc\u63a7\u5236\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u548c\u8840\u7ba1\u666f\u89c2\uff0c\u5f71\u54cd\u764c\u75c7\u7684\u591a\u4e2a\u6807\u5fd7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u764c\u75c7\u4e2d\u7684galectin\u9a71\u52a8\u56de\u8def\u53ef\u4ee5\u901a\u8fc7\u5c0f\u5206\u5b50\u78b3\u6c34\u5316\u5408\u7269\u6291\u5236\u5242\u3001\u5929\u7136\u591a\u7cd6\u53ca\u5176\u884d\u751f\u7269\u3001\u80bd\u548c\u80bd\u6a21\u62df\u7269\u3001\u4e2d\u548c\u5355\u514b\u9686\u6297\u4f53\u4ee5\u53ca\u622a\u77ed\u578bgalectin\u6765\u9776\u5411\u3002\u8bb8\u591a\u8fd9\u4e9b\u65b9\u6cd5\u76ee\u524d\u6b63\u5728\u5404\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u8fdb\u884c\u7814\u7a76\u3002Rabinovich\u5f00\u53d1\u7684Gal-1\u7279\u5f02\u6027\u4e2d\u548cmAb\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u6291\u5236\u80bf\u7624\u751f\u957f\u548c\u8840\u7ba1\u751f\u6210\uff0c\u5e76\u62b5\u6d88\u6297VEGF\u6cbb\u7597\u7684\u6297\u6027\u3002\u5b83\u8fd8\u589e\u52a0\u4e86\u514d\u75ab\u7ec6\u80de\uff08\u5c24\u5176\u662fCD8+ T\u7ec6\u80de\uff09\u8fdb\u5165\u80bf\u7624\u7684\u6d78\u6da6\uff0c\u5e76\u8bf1\u5bfcMDSCs\u7684\u91cd\u7f16\u7a0b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.\u57fa\u4e8e\u767d\u4ecb\u7d20-8\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u548cNETs\u7684\u6297\u764c\u514d\u75ab\u7597\u6cd5\u7b56\u7565<\/strong><\/p>\n<\/section>\n

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Ignacio Melero – Cl\u00ednica Universidad de Navarra, Pamplona, Spain<\/strong><\/p>\n<\/section>\n

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\u764c\u75c7\u4e2d\u514d\u75ab\u7cfb\u7edf\u7684\u4f5c\u7528\u662f\u590d\u6742\u4e14\u5e38\u5e38\u77db\u76fe\u7684\uff0c\u56e0\u4e3a\u4e00\u4e9b\u514d\u75ab\u7ec6\u80de\u52aa\u529b\u5bf9\u6297\u764c\u75c7\uff0c\u800c\u5176\u4ed6\u7ec6\u80de\u5219\u4fdd\u62a4\u5b83\u3002\u6b63\u5982Ignacio Melero\u6240\u8bf4\uff0c\u8fd9\u8981\u6c42\u514d\u75ab\u6cbb\u7597\u5e08\u540c\u65f6\u626e\u6f14\u7eb5\u706b\u72af\u548c\u6d88\u9632\u5458\u7684\u89d2\u8272\u3002\u4e3a\u4e86\u6291\u5236\u4e0d\u826f\u7684\u514d\u75ab\u53cd\u5e94\uff0cMelero\u4e13\u6ce8\u4e8e\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u5b83\u4eec\u53ef\u4ee5\u53d1\u6325\u591a\u79cd\u4f5c\u7528\uff0c\u4f46\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u4fc3\u764c\u7684\uff0c\u4e0e\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e2d\u6027\u7c92\u7ec6\u80de\u80fd\u591f\u8fdb\u884c\u8131\u9897\u7c92\u4f5c\u7528\u3001\u541e\u566c\/\u5185\u8d28\u6ce1\u541e\u4f5c\u7528\u3001\u4ea7\u751f\u6d3b\u6027\u6c27\u7269\u8d28\u4ee5\u53ca\u4e00\u4e2a\u79f0\u4e3aNETosis\u7684\u8fc7\u7a0b\uff0c\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u5b83\u4eec\u91ca\u653e\u5305\u88f9\u7740\u86cb\u767d\u8d28\u548c\u591a\u80bd\u7684DNA\uff0c\u5f62\u6210\u4e00\u4e2a\u7c98\u6027\u7684\u7f51\u72b6\u7ed3\u6784\uff0c\u80fd\u6355\u83b7\u5e76\u6740\u6b7b\u5fae\u751f\u7269\uff0c\u8fd9\u4e2a\u7f51\u72b6\u7ed3\u6784\u5373\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u7ec6\u80de\u5916\u9677\u9631\uff08NETs\uff09\u3002\u5728\u764c\u75c7\u73af\u5883\u4e2d\uff0c\u5df2\u77e5NETs\u5728\u652f\u6301\u8f6c\u79fb\u548c\u6291\u5236\u514d\u75ab\u53cd\u5e94\u4e2d\u8d77\u5230\u4e86\u5173\u952e\u7684\u4f5c\u7528\u3002Melero\u548c\u4ed6\u7684\u540c\u4e8b\u53d1\u73b0\uff0c\u8fd9\u4e9bNETs\u53ef\u80fd\u901a\u8fc7\u963b\u6b62T\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u7684\u7269\u7406\u63a5\u89e6\uff0c\u6765\u5e2e\u52a9\u6076\u6027\u7ec6\u80de\u5b58\u6d3b\uff0c\u4ece\u800c\u4fdd\u62a4\u764c\u75c7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76IL-8\u662f\u56e0\u4e3a\u5df2\u77e5\u5b83\u80fd\u5438\u5f15\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5728\u591a\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\u4e2d\uff0c\u764c\u75c7\u60a3\u8005\u4e2d\u9ad8IL-8\u8868\u8fbe\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u53cd\u5e94\u8f83\u5dee\u76f8\u5173\uff0c\u751a\u81f3\u53ef\u4ee5\u4f5c\u4e3a\u72ec\u7acb\u4e8ePD-L1\u548c\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u7684\u53cd\u5e94\u751f\u7269\u6807\u5fd7\u7269\u3002IL-8\u8fd8\u4e0e\u80bf\u7624\u4e2d\u4e2d\u6027\u7c92\u7ec6\u80de\u3001NETosis\u548c\u5355\u6838\u7ec6\u80de\u7684\u5b58\u5728\u5448\u6b63\u76f8\u5173\uff0c\u4e0eT\u7ec6\u80de\u548cIFN\u03b3\u5448\u8d1f\u76f8\u5173\u3002\u5728\u66f4\u4ed4\u7ec6\u5730\u7814\u7a76IL-8\u7684\u6d53\u5ea6\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4f4e\u6d53\u5ea6\u7684IL-8\u8bf1\u5bfc\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u8fc1\u79fb\u548c\u62db\u52df\uff0c\u800c\u9ad8\u6d53\u5ea6\u7684IL-8\u5219\u8d1f\u8d23\u8bf1\u5bfcNETosis\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9274\u4e8eIL-8\u4e0eCXCR1\u548cCXCR2\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\uff0cMelero\u7b49\u4eba\u8bc1\u660e\uff0c\u963b\u65adCXCR1\/2\u6216\u963b\u65adCXCR1\/2\u4e0b\u6e38\u4fe1\u53f7\u5206\u5b50\u53ef\u4ee5\u51cf\u5c11\u80bf\u7624\u7c7b\u5668\u5b98\u3001\u643a\u5e26\u5c0f\u9f20\u80bf\u7624\u7684\u5c0f\u9f20\u548c\u643a\u5e26\u4eba\u80bf\u7624\u7684\u4eba\u6e90\u5316\u5c0f\u9f20\u4e2d\u7684NETosis\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u79cd\u963b\u65ad\u8fd8\u6539\u5584\u4e86CD8+ T\u7ec6\u80de\u548cNK\u7ec6\u80de\u4ecb\u5bfc\u7684\u80bf\u7624\u6740\u4f24\u3002\u4e0e\u6b64\u76f8\u4e00\u81f4\uff0c\u4e0d\u540c\u80bf\u7624\u4e2dNET\u8868\u8fbe\u4e0eIL-8\u4ea7\u751f\u5448\u6b63\u76f8\u5173\uff0c\u4e0eCD8+ T\u7ec6\u80de\u5bc6\u5ea6\u5448\u8d1f\u76f8\u5173\uff1b\u901a\u8fc7\u8840\u6e05\u4e2d\u7684NET\u6d4b\u91cf\u4e5f\u53ef\u4ee5\u5f97\u5230\u7c7b\u4f3c\u7684\u76f8\u5173\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u63a5\u4e0b\u6765\uff0c\u4e3a\u4e86\u7814\u7a76\u80bf\u7624\u4e2dIL-8\u4ea7\u751f\u7684\u589e\u52a0\u662f\u7531\u4ec0\u4e48\u9a71\u52a8\u7684\uff0cMelero\u5c06\u6ce8\u610f\u529b\u8f6c\u5411\u4e86\u7531TNF\u0251\u548cIL-1\u03b2\u8bf1\u5bfc\u7684NF-\u03baB\u3002\u89c2\u5bdf\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\uff08IL-8\uff0cTNF\u0251\u548cIL-1\u03b2\uff09\u5728\u8840\u6e05\u4e2d\u7684\u76f8\u5173\u6027\uff0c\u5c0f\u9f20\u4e2d\u4e5f\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u7684\u6548\u5e94\uff08\u4f7f\u7528CXCL1\u548cCXCL2\u4f5c\u4e3aIL-8\u7684\u540c\u6e90\u7269\uff09\u3002\u6b64\u5916\uff0c\u963b\u65ad\u6216\u6ce8\u5c04TNF\u0251\u548cIL-1\u03b2\u53ef\u4ee5\u6709\u6548\u5730\u963b\u6b62\u6216\u4fc3\u8fdbIL-8\u7684\u4ea7\u751f\u3002\u4ece\u63a5\u53d7\u6297TNF\u0251\u6297\u4f53\u6cbb\u7597\u7684\u60a3\u8005\u6837\u672c\u4e2d\u8bc1\u660e\u4e86\u8fd9\u4e00\u70b9\uff0c\u6cbb\u7597\u540e24\u5c0f\u65f6\uff0cIL-8\u8840\u6e05\u6c34\u5e73\u964d\u4f4e\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u963b\u65adCXCR1\/2\u6216IL-8\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5c3d\u7ba1\u9700\u8981\u9ad8\u5242\u91cf\u624d\u80fd\u5b8c\u5168\u4e2d\u548cIL-8\uff0c\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u6cbb\u7597\u5df2\u88ab\u8bc1\u660e\u662f\u5b89\u5168\u7684\uff0c\u5373\u4f7f\u4e0enivolumab\u548cipilimumab\u8054\u5408\u4f7f\u7528\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u89c2\u5bdf\u5230\u6cbb\u7597\u80bf\u7624\u4e2d\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u51cf\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u4e0e\u9002\u5e94\u6027\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff1a\u4e73\u817a\u764c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u65b0\u8fdb\u5c55<\/strong><\/p>\n<\/section>\n

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Karin E. de Visser – \u8377\u5170\u764c\u75c7\u7814\u7a76\u6240\uff0c\u963f\u59c6\u65af\u7279\u4e39\uff0c\u8377\u5170<\/strong><\/p>\n<\/section>\n

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\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u5df2\u88ab\u8bc1\u660e\u5bf9\u5b9e\u4f53\u7624\u6709\u6548\uff0c\u4f46\u5728\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u7684\u5e94\u7b54\u7387\u4ee4\u4eba\u5931\u671b\uff0c\u4ec5\u67095-10%\u7684\u60a3\u8005\u6709\u5e94\u7b54\u3002\u5c3d\u7ba1PD-L1\u9633\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u60a3\u8005\u5728ICB\u52a0\u5316\u7597\u65b9\u6848\u4e0b\u5e94\u7b54\u7387\u6709\u6240\u6539\u5584\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u4ecd\u65e0\u6cd5\u5bf9ICB\u4ea7\u751f\u5e94\u7b54\u3002\u5c3d\u7ba1\u5927\u591a\u6570\u5173\u4e8eICB\u5e94\u7b54\u7684\u7814\u7a76\u90fd\u96c6\u4e2d\u5728T\u7ec6\u80de\u4e0a\uff0c\u4f46\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5bf9\u6709\u6548\u514d\u75ab\u5e94\u7b54\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Karin de Visser\u53ca\u5176\u540c\u4e8b\u5bf9TONIC\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7ICB\u6cbb\u7597\u7684TNBC\u60a3\u8005\u7684\u8840\u6db2\u548c\u8f6c\u79fb\u75c5\u7076\u4e2d\u514d\u75ab\u7ec6\u80de\u52a8\u6001\u8fdb\u884c\u4e86\u65e0\u504f\u501a\u7684\u5206\u6790\u3002\u901a\u8fc7\u4e0e\u5c0f\u9f20\u7814\u7a76\u76f8\u7ed3\u5408\uff0c\u8fd9\u4f7f\u4ed6\u4eec\u80fd\u591f\u7814\u7a76\u4e0e\u5e94\u7b54\u76f8\u5173\u7684\u514d\u75ab\u53c2\u6570\u3002\u5728\u63a5\u53d7ICB\u6cbb\u7597\u7684\u5e94\u7b54\u60a3\u8005\u4e2d\uff0c\u89c2\u5bdf\u5230\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u5728\u5168\u8eab\u548c\u80bf\u7624\u5185\u7684\u589e\u52a0\uff0c\u800c\u5728\u975e\u5e94\u7b54\u60a3\u8005\u4e2d\u5219\u6ca1\u6709\u89c2\u5bdf\u5230\u8fd9\u79cd\u60c5\u51b5\u3002\u5728TONIC\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5168\u8eab\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u589e\u52a02\u500d\u4ee5\u4e0a\u4e0e\u66f4\u597d\u7684\u603b\u751f\u5b58\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u57fa\u56e0\u5de5\u7a0b\u7684KEP\uff08K14-cre\uff1bCdh1f\/f\uff1bTrp53f\/f\uff09\u5c0f\u9f20\u4e2d\uff0c\u81ea\u53d1\u6027\u4fb5\u88ad\u6027\u4e73\u817a\u764c\u5bf9ICB\u5355\u72ec\u6cbb\u7597\u6ca1\u6709\u53cd\u5e94\uff0c\u4f46\u5bf9ICB\u548c\u987a\u94c2\u7684\u8054\u5408\u6cbb\u7597\u4ee5T\u7ec6\u80de\u4f9d\u8d56\u7684\u65b9\u5f0f\u6709\u53cd\u5e94\uff0c\u8fd9\u4e0eTNBC\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u60c5\u51b5\u7c7b\u4f3c\u3002\u5728\u8fd9\u4e2a\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cICB\u548c\u987a\u94c2\u7684\u8054\u5408\u5bfc\u81f4\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u5728\u5168\u8eab\u548c\u80bf\u7624\u5185\u589e\u52a0\u3002\u7528\u6297SiglecF\u6297\u4f53\u8017\u7aed\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u4f7fICB\u8054\u5408\u987a\u94c2\u7684\u6cbb\u7597\u6548\u679c\u6d88\u5931\u3002\u5728\u53e6\u4e00\u4e2a\u57fa\u4e8eKEP\u7684\u591a\u5668\u5b98\u8f6c\u79fb\u6027\u75be\u75c5\u6a21\u578b\u4e2d\uff0cICB\u8054\u5408\u987a\u94c2\u4ee5\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u4f9d\u8d56\u7684\u65b9\u5f0f\u8bf1\u5bfc\u51fa\u6301\u4e45\u7684\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u4e86\u89e3\u6cbb\u7597\u5982\u4f55\u8c03\u52a8\u55dc\u9178\u6027\u7c92\u7ec6\u80de\uff0cde Visser\u53ca\u5176\u56e2\u961f\u5206\u6790\u4e86\u8840\u6d46\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u53d1\u73b0\u5728ICB\u6cbb\u7597\u7684\u5c0f\u9f20\u4e2dIL-5\u6c34\u5e73\u4e0a\u8c03\uff0c\u800cIL-5\u4e2d\u548c\u4f5c\u7528\u6d88\u9664\u4e86ICB\u7684\u6cbb\u7597\u6548\u679c\u3002\u7531\u4e8eCD4+ T\u7ec6\u80de\u662fIL-5\u7684\u4e3b\u8981\u4ea7\u751f\u8005\uff0c\u7814\u7a76\u8005\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u9009\u4e86TNBC\u60a3\u8005\u63a5\u53d7ICB\u6cbb\u7597\u7684CD4+ T\u7ec6\u80de\uff0c\u5e76\u5728\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u53d1\u73b0IL-5mRNA\u4e0a\u8c03\u3002\u6d88\u8017CD4+ T\u7ec6\u80de\u5bfc\u81f4\u5c0f\u9f20\u6a21\u578b\u4e2d\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7279\u5f81\u7684\u4e22\u5931\uff0c\u8fd9\u8868\u660eICB\u6cbb\u7597\u8bf1\u5bfcCD4+ T\u7ec6\u80de\u4ea7\u751fIL-5\uff0c\u4ece\u800c\u589e\u52a0\u9aa8\u9ad3\u4e2d\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u4ea7\u751f\uff0c\u5e76\u5bfc\u81f4\u5168\u8eab\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u79ef\u7d2f\u548c\u6fc0\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u786e\u5b9a\u5bfc\u81f4\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8fdb\u5165\u80bf\u7624\u7684\u56e0\u7d20\uff0c\u7814\u7a76\u4eba\u5458\u5206\u6790\u4e86\u987a\u94c2\u52a0ICB\u6cbb\u7597\u60a3\u8005\u8840\u6d46\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u53d1\u73b0\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u5df2\u77e5\u7684\u8d8b\u5316\u5242IL-33\u4ec5\u5728\u987a\u94c2\u6cbb\u7597\u65f6\u4e0a\u8c03\u3002IL-33\u4e2d\u548c\u4f5c\u7528\u6d88\u9664\u4e86\u80bf\u7624\u5185\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u79ef\u7d2f\uff0c\u5e76\u964d\u4f4e\u4e86\u5bf9\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u7684\u63a7\u5236\u3002\u540c\u6837\uff0cIL-33\u6c34\u5e73\u4e0eICB\u5e94\u7b54\u60a3\u8005\uff08\u800c\u975e\u975e\u5e94\u7b54\u60a3\u8005\uff09\u7684\u80bf\u7624\u6837\u672c\u4e2d\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u57fa\u56e0\u7279\u5f81\u76f8\u5173\u3002\u7528\u91cd\u7ec4IL-33\u5168\u8eab\u6cbb\u7597\u5c0f\u9f20\u4ee5\u6a21\u62df\u987a\u94c2\u7684\u4f5c\u7528\uff0c\u589e\u52a0\u80bf\u7624\u5185\u55dc\u9178\u6027\u7c92\u7ec6\u80de\uff0c\u4f46\u9700\u8981\u4e0eICB\u8054\u5408\u4ee5\u6fc0\u6d3bCD8+ T\u7ec6\u80de\u3002\u5728\u53e6\u4e00\u79cd\u7b56\u7565\u4e2d\uff0cTreg\u6d88\u8017\u5bfc\u81f4\u80bf\u7624\u5185\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u79ef\u7d2f\uff0c\u540c\u6837\uff0c\u4e0eICB\u6cbb\u7597\u7684\u8054\u5408\u662f\u5728\u8f6c\u79fb\u6027KEP\u57fa\u7840\u80bf\u7624\u6a21\u578b\u4e2d\u6539\u5584\u751f\u5b58\u7684\u5fc5\u8981\u6761\u4ef6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u4e4b\uff0cICB\u8054\u5408\u987a\u94c2\u6cbb\u7597\u8bf1\u5bfcCD4+ T\u7ec6\u80de\u4ea7\u751fIL-5\uff0c\u8fd9\u589e\u52a0\u4e86\u9aa8\u9ad3\u4e2d\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u4ea7\u751f\uff0c\u5bfc\u81f4\u5168\u8eab\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u79ef\u7d2f\u548c\u6fc0\u6d3b\uff0c\u8fd9\u4e9b\u7ec6\u80de\u88ab\u4ea7\u751fIL-33\u7684\u80bf\u7624\u5438\u5f15\uff0c\u4ece\u800c\u6539\u5584\u4e73\u817a\u764c\u7684ICB\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4.\u514d\u75ab\u6cbb\u7597\u4e2d\u80a0\u9053\u548c\u80bf\u7624\u5fae\u751f\u7269\u4ecb\u5bfc\u514d\u75ab\u5e94\u7b54\u7684\u673a\u5236<\/strong><\/p>\n<\/section>\n

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Florencia McAllister – UT MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff0c\u4f11\u65af\u987f\uff0cTX<\/strong><\/p>\n<\/section>\n

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\u8bb8\u591a\u7c7b\u578b\u7684\u5fae\u751f\u7269\uff0c\u5c24\u5176\u662f\u7ec6\u83cc\uff0c\u5728\u6240\u6709\u5177\u6709\u7c98\u819c\u7ec4\u7ec7\u7684\u8eab\u4f53\u5c4f\u969c\u6216\u8eab\u4f53\u5c4f\u969c\u53ef\u80fd\u88ab\u75c5\u539f\u4f53\u7834\u574f\u7684\u5730\u65b9\u90fd\u975e\u5e38\u4e30\u5bcc\uff0c\u56e0\u6b64\u53ef\u80fd\u5bf9\u5404\u79cd\u7c7b\u578b\u7684\u764c\u75c7\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\u3002\u5173\u4e8e\u80a0\u9053\u83cc\u7fa4\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u7684\u5f71\u54cd\u7684\u7814\u7a76\u5f15\u9886\u4e86\u8fd9\u4e2a\u9886\u57df\u7684\u53d1\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Florencia McAllister\u9996\u5148\u7b80\u8981\u56de\u987e\u4e86\u5979\u7684\u56e2\u961f\u548c\u5176\u4ed6\u56e2\u961f\u53d1\u8868\u7684\u7814\u7a76\uff0c\u91cd\u70b9\u5f3a\u8c03\u4e86\u6761\u4ef6\u63a7\u5236\uff08\u5730\u7406\u8303\u56f4\u5185\u7684\u961f\u5217\u3001\u6536\u96c6\u65b9\u6cd5\u7b49\uff09\u7684\u91cd\u8981\u6027\uff0c\u5e76\u4e14\u5e94\u7528\u4e86\u591a\u79cd\u73b0\u6709\u548c\u6b63\u5728\u5f00\u53d1\u7684\u5de5\u5177\u6765\u63d0\u5347\u53ef\u4fe1\u5ea6\uff0c\u4ee5\u53ca\u5bfb\u627e\u529f\u80fd\u548c\u673a\u5236\u4fe1\u606f\u4ee5\u4fbf\u5c06\u6765\u91c7\u7528\u66f4\u6709\u9488\u5bf9\u6027\u7684\u65b9\u6cd5\u3002\u91cd\u70b9\u5173\u6ce8\u80bf\u7624\u5185\u5fae\u751f\u7269\uff08TRMs\uff09\uff0c\u91cd\u8981\u7684\u65b0\u5de5\u5177\u5305\u62ec\u8bc4\u4f30\u5fae\u751f\u7269\u4e0e\u80bf\u7624\u548c\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u7a7a\u95f4\u5173\u7cfb\uff0c\u4ee5\u53ca\u5b9a\u91cf\u548c\u5b9a\u6027\u7684\u7269\u79cd\u9274\u5b9a\u65b0\u6838\u9178\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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McAllister\u8fd8\u63d0\u4f9b\u4e86\u4e00\u4e9b\u5173\u4e8e\u5fae\u751f\u7269\u4e0e\u836f\u7269\u6cbb\u7597\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3001\u514d\u75ab\u6fc0\u6d3b\u6216\u6291\u5236\u5fae\u751f\u7269\u5bf9\u80f0\u817a\u764c\u751f\u5b58\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5fae\u751f\u7269\u4e0e\u539f\u53d1\u6027\u548c\u8f6c\u79fb\u6027\u80bf\u7624\u4e4b\u95f4\u5173\u7cfb\u7684\u5f00\u521b\u6027\u4f8b\u5b50\u3002\u5728\u5979\u7684\u65b0\u5de5\u4f5c\u4e2d\uff0cMcAllister\u5f00\u53d1\u4e86\u4e00\u79cd\u91cf\u5316\u5fae\u751f\u7269\/\u5bbf\u4e3bDNA\u6bd4\u4f8b\u7684\u5de5\u5177\uff0c\u4ee5\u5e7f\u6cdb\u6d4b\u91cf\u6574\u4f53\u80bf\u7624\u5185\u7684\u5fae\u751f\u7269\u8d1f\u8377\uff08ITMB\uff09\u3002\u6709\u8da3\u7684\u662f\uff0c\u5c06\u8be5\u5de5\u5177\u5e94\u7528\u4e8e4\u79cd\u80bf\u7624\u7c7b\u578b\uff08\u80c3\u3001\u7ed3\u76f4\u80a0\u3001\u4e73\u817a\u548c\u5b50\u5bab\uff09\u7684TCGA\u6570\u636e\uff0c\u53d1\u73b0\u5728\u4e0e\u80a0\u9053\u76f8\u5173\u7684\u80c3\u548c\u7ed3\u76f4\u80a0\u80bf\u7624\u4e2d\u9ad8ITMB\u4e0e\u591a\u79cd\u514d\u75ab\u9014\u5f84\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u9ad8ITMB\u4e0e\u6fc0\u6d3b\u7684\u80a5\u5927\u7ec6\u80de\u589e\u52a0\u548c\u9759\u6b62\u80a5\u5927\u7ec6\u80de\u51cf\u5c11\u76f8\u5173\u3002\u8fd9\u4e9b\u7ed3\u679c\u901a\u8fc716S\u6d4b\u5e8f\u548cIHC\u5b9e\u9a8c\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u901a\u8fc7\u5c06\u6297\u751f\u7d20\u76f4\u63a5\u6ce8\u5165MC38\u80bf\u7624\u4e2d\u6765\u8c03\u8282\u80bf\u7624\u5185\u7ec6\u83cc\uff0c\u964d\u4f4e\u4e86\u80a5\u5927\u7ec6\u80de\u6c34\u5e73\uff0c\u800c\u76f8\u53cd\u5730\uff0c\u901a\u8fc7\u5c40\u90e8\u6297\u4f53\u963b\u65ad\u80a5\u5927\u7ec6\u80de\u5bfc\u81f4\u5fae\u751f\u7269\u6570\u91cf\u663e\u8457\u589e\u52a0\uff0c\u8868\u660e\u5bbf\u4e3b\u4e0e\u4fb5\u5165\u6027\u5fae\u751f\u7269\u4e4b\u95f4\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u3002\u901a\u8fc7\u7814\u7a76\u8fd9\u4e9b\u53d8\u5316\u662f\u5426\u5f71\u54cdICB\u7597\u6cd5\uff0c\u4e24\u79cd\u514d\u75ab\u6cbb\u7597\u654f\u611f\u80bf\u7624\uff08MC-38\u548cE0771\uff09\u4e2d\u6297\u751f\u7d20\u7684\u76f4\u63a5\u80bf\u7624\u5185\u6ce8\u5c04\uff08\u4e3b\u8981\u5728\u80bf\u7624\u8fb9\u7f18\uff09\u964d\u4f4e\u4e86ICB\u53cd\u5e94\uff0c\u8868\u660e\u80bf\u7624\u5185\u5fae\u751f\u7269\u5bf9ICB\u53cd\u5e94\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u5728\u4e00\u79cd\u672c\u8eab\u5bf9\u514d\u75ab\u6cbb\u7597\u4e0d\u654f\u611f\u7684\u80f0\u817a\u80bf\u7624\uff08KPC\uff09\u4e2d\uff0c\u901a\u8fc7\u6d88\u8017\u80a5\u5927\u7ec6\u80de\u6765\u589e\u52a0\u5fae\u751f\u7269\u8d1f\u8377\uff0c\u5bfc\u81f4\u4e86\u514d\u75ab\u6cbb\u7597\u5e94\u7b54\u7684\u589e\u5f3a\uff0c\u800c\u8fd9\u79cd\u5e94\u7b54\u53c8\u88ab\u6297\u751f\u7d20\u6cbb\u7597\u6240\u6d88\u9664\uff0c\u8868\u660e\u7531\u80a5\u5927\u7ec6\u80de\u8017\u7aed\u6240\u589e\u52a0\u7684\u80bf\u7624\u5185\u5fae\u751f\u7269\u662f\u9a71\u52a8\u8fd9\u79cd\u5e94\u7b54\u7684\u5173\u952e\u56e0\u7d20\u3002\u603b\u4e4b\uff0c\u8fd9\u9879\u5de5\u4f5c\u5f3a\u8c03\u4e86\u80bf\u7624\u5185\u5fae\u751f\u7269\u4e0e\u514d\u75ab\u6cbb\u7597\u7ed3\u679c\u7684\u76f4\u63a5\u76f8\u5173\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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5.\u80bf\u7624\u5fae\u73af\u5883\u4ee3\u8c22\u7269\u5851\u9020\u4e86\u764c\u75c7\u4e2dT\u7ec6\u80de\u7684\u547d\u8fd0\u548c\u529f\u80fd<\/strong><\/p>\n<\/section>\n

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Greg M. Delgoffe – \u5339\u5179\u5821\u5927\u5b66\uff0c\u5339\u5179\u5821\uff0c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde<\/strong><\/p>\n<\/section>\n

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\u8fd9\u662f\u504f\u79bb\u8bb2\u8005\u539f\u8ba1\u5212\u7684\u8bb2\u5ea7\uff0cGreg Delgoffe\u4ecb\u7ecd\u4e86\u4e00\u4e9b\u5173\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u4ee3\u8c22\u7279\u5f81\u53ca\u5176\u4e0e\u514d\u75ab\u6291\u5236\u5173\u7cfb\u7684\u65b0\u9896\u4e14\u4ee4\u4eba\u5174\u594b\u7684\u5de5\u4f5c\u3002\u80bf\u7624\u7ec6\u80de\u6539\u53d8\u5176\u4ee3\u8c22\u65b9\u5f0f\uff0c\u8fd9\u53cd\u8fc7\u6765\u5f71\u54cd\u5176\u76f4\u63a5\u73af\u5883\uff0c\u5373TME\u7684\u95f4\u8d28\u6db2\u7684\u4ee3\u8c22\u7ec4\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u957f\u671f\u4ee5\u6765\u4eba\u4eec\u6240\u719f\u77e5\u7684\u4f8b\u5b50\u5305\u62ec\u8f83\u9ad8\u7684\u6c27\u6c14\u6d88\u8017\uff0c\u5bfc\u81f4\u7f3a\u6c27\u548c\u6d3b\u6027\u6c27\u7269\u8d28\u7684\u79ef\u7d2f\uff0c\u4ee5\u53ca\u8f83\u9ad8\u7684\u7cd6\u9175\u89e3\u901f\u7387\uff0c\u5bfc\u81f4\u4f4e\u8840\u7cd6\u548c\u4e73\u9178\u79ef\u7d2f\u3002\u591a\u4f4d\u7814\u7a76\u8005\u5df2\u7ecf\u8bc1\u660e\uff0c\u8fd9\u4e9b\u53d8\u5316\u4f1a\u5f71\u54cd\u5c40\u90e8T\u7ec6\u80de\u751f\u7269\u5b66 – CD8+ T\u7ec6\u80de\u56e0\u7f3a\u6c27\u800c\u8017\u7aed\uff0cCD4+ T\u7ec6\u80de\u56e0\u8461\u8404\u7cd6\u51cf\u5c11\u800c\u5411\u8c03\u8282\u6027\u7ec6\u80de\u5206\u5316\u3002\u7136\u800c\uff0c\u5c1a\u7f3a\u4e4f\u76f4\u63a5\u5c06\u7279\u5b9a\u4ee3\u8c22\u7269\u53d8\u5316\u4e0eTME\u4e2dT\u7ec6\u80de\u53d8\u5316\u8054\u7cfb\u8d77\u6765\u7684\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Delgoffe\u548c\u4ed6\u7684\u5408\u4f5c\u8005\u901a\u8fc7\u5bf9\u5c0f\u9f20KPC\uff08KrasG12Dp53f\/fPdx1cre\uff09\u80bf\u7624\u7684\u80bf\u7624\u95f4\u8d28\u6db2\uff08TIF\uff09\u7684\u4ee3\u8c22\u7ec4\u6210\u8fdb\u884c\u5b9a\u91cf\u8868\u5f81\uff0c\u751f\u6210\u57fa\u4e8eTIF\u7684\u5316\u5b66\u5b9a\u4e49\u57f9\u517b\u57fa\uff08\u53ef\u4ee5\u975e\u5e38\u7279\u5f02\u6027\u5730\u8fdb\u884c\u914d\u65b9\u7684\u4fee\u6539\uff09\uff0c\u5e76\u76f4\u63a5\u5206\u6790T\u7ec6\u80de\u5bf9\u8fd9\u79cd\u53d8\u5316\u7684\u8868\u578b\u53cd\u5e94\u6765\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002\u521d\u6b65\u5b9e\u9a8c\u8868\u660e\uff0c\u5728\u6b63\u5e38\u57f9\u517b\u57fa\uff08\u53cd\u6620\u6b63\u5e38\u5916\u5468\uff09\u4e2d\u6d3b\u5316\u7684T\u7ec6\u80de\uff0c\u8f6c\u79fb\u5230TIF\u57f9\u517b\u57fa\uff08\u53cd\u6620\u80bf\u7624\uff09\u540e\uff0c\u5982\u679c\u5728\u8f6c\u79fb\u540e\u4e0d\u4e45\u91cd\u65b0\u523a\u6fc0\uff0c\u4ec5\u663e\u793a\u51fa\u8f7b\u5fae\u7684\u6291\u5236\u3002\u7136\u800c\uff0c\u5728TIF\u57f9\u517b\u57fa\u4e2d\u957f\u65f6\u95f4\u66b4\u9732\u540e\uff0c\u91cd\u65b0\u523a\u6fc0\u524d\uff0cPD-1\u9010\u6e10\u4e0a\u8c03\uff0c\u591a\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u51cf\u5c11\uff0c\u7ec6\u80de\u751f\u957f\u901f\u5ea6\u663e\u8457\u51cf\u7f13\uff0c\u5373\u4f7f\u5728\u6b63\u5e38\u57f9\u517b\u57fa\u4e2d\u91cd\u65b0\u523a\u6fc0T\u7ec6\u80de\uff0c\u4e5f\u8868\u73b0\u51fa\u7a33\u5b9a\u7684\u6291\u5236\u6027\u53d8\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u786e\u5b9aTIF\u57f9\u517b\u57fa\u4e2d\u53ef\u80fd\u7f3a\u5931\u7684\u7269\u8d28\uff0c\u5c06TIF\u57f9\u517b\u57fa\u4e0e\u8840\u6d46\u8fdb\u884c\u5b9a\u91cf\u6bd4\u8f83\uff0c\u53d1\u73b0\u591a\u79cd\u88ab\u8017\u5c3d\u7684\u4ee3\u8c22\u7269\u3002\u8865\u5145\u5b9e\u9a8c\u786e\u5b9a\u4e86\u7cbe\u6c28\u9178\u662f\u80fd\u591f\u633d\u6551T\u7ec6\u80dePD-1\u548c\u589e\u6b96\u8868\u578b\u7684\u5173\u952e\u4ee3\u8c22\u7269\uff0c\u4f46\u4e0d\u80fd\u6062\u590d\u591a\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u3002\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u91cd\u70b9\u653e\u5728\u4e86\u76f8\u5bf9\u4e8e\u8840\u6d46\u5728TIF\u57f9\u517b\u57fa\u4e2d\u79ef\u7d2f\u7684\u7269\u8d28\u4e0a\uff0c\u4ed6\u4eec\u786e\u5b9a\u4e86\u591a\u4e2a\u6709\u8da3\u7684\u5019\u9009\u7269\u8d28\uff0c\u4f46\u5c06\u7814\u7a76\u91cd\u70b9\u653e\u5728\u4e86\u78f7\u9178\u4e59\u9187\u80fa\uff08pEtn\uff09\u4e0a\uff0c\u8fd9\u662f\u4e00\u79cd\u4ece\u4e59\u9187\u80fa\u5230\u78f7\u8102\u9170\u4e59\u9187\u80fa\uff08PE\uff09\u7684\u9014\u5f84\u4e0a\u7684\u4ee3\u8c22\u7269\uff0cPE\u662f\u7ec6\u80de\u819c\u7684\u4e30\u5bcc\u8102\u8d28\u6210\u5206\u3002\u80bf\u7624\u7ec6\u80de\u7ecf\u5e38\u964d\u4f4eECT\/Pcyt2\u9176\u7684\u8868\u8fbe\uff0c\u8be5\u9176\u662f\u5c06pEtn\u6700\u7ec8\u8f6c\u5316\u4e3aPE\u6240\u9700\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u5c06pEtn\u52a0\u5165\u6b63\u5e38\u57f9\u517b\u57fa\u4e2d\u7684T\u7ec6\u80de\u53ef\u91cd\u73b0T\u7ec6\u80de\u529f\u80fd\u969c\u788d\u72b6\u6001\u3002\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u5c06T\u7ec6\u80de\u7684\u4ee3\u8c22\u5f71\u54cd\u8ffd\u6eaf\u5230T\u7ec6\u80de\u4ee3\u8c22\u7684\u91cd\u7f16\u7a0b\uff0c\u4f7f\u5176\u5bf9pEtn\u4ea7\u751f\u4f9d\u8d56\u6027\u3002\u5c06\u4ece\u4e59\u9187\u80fa\u5230PE\u7684\u9014\u5f84\u4e2d\u7684\u5176\u4ed6\u4ee3\u8c22\u7269\u52a0\u5165\u6b63\u5e38\u57f9\u517b\u57fa\u4e2d\u4e5f\u91cd\u73b0\u4e86T\u7ec6\u80de\u529f\u80fd\u969c\u788d\uff0c\u8fd9\u8868\u660e\u5728\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u8fc7\u91cf\u4ea7\u751f\u7684PE\u662f\u529f\u80fd\u969c\u788d\u7684\u6839\u672c\u539f\u56e0\u3002\u6700\u7ec8\uff0c\u4ee3\u8c22\u91cd\u7f16\u7a0b\u7684T\u7ec6\u80de\u7528\u5c3d\u4e86\u4e8c\u9170\u7518\u6cb9\uff08DAG\uff09\u5c06pEtn\u4ee3\u8c22\u4e3aPE\uff0c\u56e0\u6b64\u8017\u5c3d\u4e86T\u7ec6\u80de\u53d7\u4f53\u4fe1\u53f7\u901a\u8def\u6240\u9700\u7684\u8fd9\u4e00\u5173\u952e\u7684\u7b2c\u4e8c\u4fe1\u4f7f\uff0c\u5bfc\u81f4T\u7ec6\u80de\u529f\u80fd\u969c\u788d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6062\u590d\u80bf\u7624\u7ec6\u80de\u4e2dpyct2\u7684\u8868\u8fbe\uff08\u4ee5\u6d88\u9664\u57f9\u517b\u57fa\u4e2dpEtn\u7684\u79ef\u7d2f\uff09\u6062\u590d\u4e86\u5b8c\u5168\u7684T\u7ec6\u80de\u529f\u80fd\uff0c\u5e76\u5bfc\u81f4\u80bf\u7624\u5927\u5c0f\u51cf\u5c0f\u3002\u4f5c\u4e3a\u4e00\u79cd\u66f4\u6613\u5904\u7406\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4f7f\u7528\u809d\u810f\u9176PEMT\u5c06T\u7ec6\u80de\u4e2d\u7684\u591a\u4f59PE\u8f6c\u5316\u4e3a\u78f7\u8102\u9170\u80c6\u78b1\u540c\u6837\u633d\u6551\u4e86T\u7ec6\u80de\u529f\u80fd\u3002\u4f5c\u4e3a\u4e00\u4e2a\u9644\u5e26\u7684\u548c\u4e00\u822c\u7684\u8b66\u793a\uff0cPMA\u7ecf\u5e38\u7528\u4e8e\u523a\u6fc0T\u7ec6\u80de\uff0c\u5305\u542bDAG\u7c7b\u4f3c\u7269\uff0c\u56e0\u6b64\u4f7f\u7528PMA\u523a\u6fc0\u53ef\u80fd\u63a9\u76d6\u4ee3\u8c22\u8bf1\u5bfc\u7684T\u7ec6\u80de\u529f\u80fd\u969c\u788d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & AACR<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n

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\u5173\u6ce8\u672c\u516c\u4f17\u53f7~<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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