{"id":4941,"date":"2023-05-06T07:06:58","date_gmt":"2023-05-05T23:06:58","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/05\/06\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e5%9b%9b%ef%bc%9a%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9\/"},"modified":"2023-05-06T07:06:58","modified_gmt":"2023-05-05T23:06:58","slug":"2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e5%9b%9b%ef%bc%9a%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/05\/06\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e5%9b%9b%ef%bc%9a%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9\/","title":{"rendered":"2023\u5e74\u5ea6\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\u56db\uff1a\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u53ca\u8054\u5408\u7597\u6cd5"},"content":{"rendered":"
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1.\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u54cd\u5e94\u548c\u62b5\u6297\u7684\u57fa\u56e0\u7ec4\u7279\u5f81<\/strong><\/p>\n<\/section>\n

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Valsamo K. Anagnostou – \u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\uff0c\u5df4\u5c14\u7684\u6469\uff0c\u9a6c\u91cc\u5170\u5dde<\/strong><\/p>\n<\/section>\n

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Valsamo Anagnostou\u805a\u7126\u4e8e\u5f71\u54cd\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u80bf\u7624\u56fa\u6709\u7279\u5f81\uff0c\u6307\u51fa\u591a\u9879\u7814\u7a76\u663e\u793a\uff0c\u9ad8\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u53cd\u5e94\u76f8\u5173\uff0c\u8fd9\u5728\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u80cc\u666f\u4e0b\u5f97\u5230\u8bc1\u5b9e\u3002\u7136\u800c\uff0c\u5728\u5c06\u7a81\u53d8\u8d1f\u8377\u4f5c\u4e3aICB\u53cd\u5e94\u751f\u7269\u6807\u5fd7\u7269\u65f6\uff0c\u591a\u79cd\u6280\u672f\u548c\u751f\u7269\u5b66\u56e0\u7d20\uff08\u80bf\u7624\u6837\u672c\u7eaf\u5ea6\uff0c\u68c0\u6d4b\u65b9\u6cd5\u7684\u7edf\u4e00\uff0c\u5176\u4ed6\u5f71\u54cd\u56e0\u7d20\uff09\u5e26\u6765\u4e86\u6311\u6218\u3002\u7136\u800c\uff0c\u6574\u5408\u5916\u663e\u5b50\u548c\u8f6c\u5f55\u7ec4\u5206\u6790\u53ef\u4ee5\u66f4\u597d\u5730\u9884\u6d4b\u5bf9ICB\u7684\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f8b\u5982\uff0c\u591a\u7ec4\u5b66\u5206\u6790\u8868\u660e\uff0c\u67d0\u4e9b\u7279\u5b9a\u7684\u57fa\u56e0\u7ec4\u7279\u5f81\u4e0e\u6cdb\u764c\u75c7\u53cd\u5e94\u76f8\u5173\uff0c\u800c\u6709\u4e9b\u5219\u662f\u764c\u75c7\u7c7b\u578b\u548c\u8c31\u7cfb\u7279\u5f02\u6027\u7684\u3002\u5728\u5316\u5b66\u514d\u75ab\u6cbb\u7597\u4e0b\u6d88\u9000\u7684\u80bf\u7624\u5177\u6709\u66f4\u9ad8\u7a0b\u5ea6\u7684\u67d3\u8272\u4f53\u4e0d\u5e73\u8861\uff0c\u8fd9\u8868\u660e\u67d3\u8272\u4f53\u7f3a\u5931\u53ef\u4ee5\u6d88\u9664\u5355\u500d\u4f53\u533a\u57df\u4e2d\u7684\u7a81\u53d8\uff0c\u56e0\u6b64\uff0c\u8fd9\u4e9b\u7a81\u53d8\u6301\u7eed\u5b58\u5728\u5e76\u4e0eICB\u53cd\u5e94\u76f8\u5173\u3002Valsamo\u53ca\u5176\u540c\u4e8b\u56e0\u6b64\u5047\u8bbe\uff0c\u5b58\u5728\u4e00\u4e9b\u7a81\u53d8\u4e9a\u7fa4\uff08\u201c\u6301\u4e45\u7a81\u53d8\u201d\uff09\uff0c\u5b83\u4eec\u5728\u751f\u7269\u5b66\u4e0a\u662f\u4e0d\u540c\u7684\uff0c\u4e0d\u592a\u53ef\u80fd\u901a\u8fc7\u67d3\u8272\u4f53\u7f3a\u5931\u800c\u88ab\u5220\u9664\uff08\u8fd9\u5bf9\u7ec6\u80de\u6765\u8bf4\u662f\u81f4\u547d\u7684\u4e8b\u4ef6\uff09\uff0c\u4ece\u800c\u5bfc\u81f4\u6301\u7eed\u7684\u80bf\u7624\u514d\u75ab\u63a7\u5236\u3002\u8fd9\u4e9b\u6301\u4e45\u7a81\u53d8\u53ef\u4ee5\u662f\u5355\u500d\u4f53\u533a\u57df\u4e2d\u7684\u5355\u62f7\u8d1d\u7a81\u53d8\u6216\u591a\u62f7\u8d1d\u7a81\u53d8\uff0c\u4e0d\u540c\u4e8e\u5bb9\u6613\u4e22\u5931\u7684\u4e8c\u500d\u4f53\u533a\u57df\u4e2d\u7684\u5355\u62f7\u8d1d\u7a81\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u80ba\u764c\u7684\u4f8b\u5b50\u4e2d\uff0c\u57fa\u7ebf\u80bf\u7624\u4e2d\u5b58\u5728\u7684\u4e00\u7ec4\u5019\u9009\u7a81\u53d8\u76f8\u5173\u65b0\u6297\u539f\u5728ICB\u8010\u836f\u80bf\u7624\u4e2d\u88ab\u6d88\u9664\uff0c\u5e76\u53ef\u80fd\u63a8\u52a8\u8010\u836f\u6027\u7684\u51fa\u73b0\u3002\u65b0\u6297\u539f\u7684\u4e22\u5931\u8981\u4e48\u662f\u901a\u8fc7\u514d\u75ab\u6d88\u9664\u542b\u6709\u65b0\u6297\u539f\u7684\u7ec6\u80de\uff0c\u8981\u4e48\u662f\u901a\u8fc7\u5bfc\u81f4\u65b0\u6297\u539f\u4e22\u5931\u548c\u8010\u836f\u514b\u9686\u6269\u589e\u7684\u9057\u4f20\u4e8b\u4ef6\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728\u80ba\u764c\u793a\u4f8b\u4e2d\uff0c\u51e0\u79cd\u5177\u6709\u514d\u75ab\u539f\u6027\u7684\u65b0\u6297\u539f\u7a81\u53d8\u901a\u8fc7\u9057\u4f20\u4e8b\u4ef6\u88ab\u6d88\u9664\uff0c\u4e0e\u8fd9\u4e9b\u9057\u4f20\u4e8b\u4ef6\u5bfc\u81f4\u80bf\u7624\u62b5\u6297\u662f\u4e00\u81f4\u7684\u3002\u901a\u8fc7\u91cf\u5316\u6301\u4e45\u6027\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08pTMB\uff1b\u5355\u62f7\u8d1d\u6216\u591a\u62f7\u8d1d\u6301\u4e45\u7a81\u53d8\uff09\uff0c\u53d1\u73b0\u6301\u4e45\u7a81\u53d8\u7684\u6bd4\u4f8b\u4ee5\u53ca\u591a\u62f7\u8d1d\u4e0e\u5355\u62f7\u8d1d\u7a81\u53d8\u7684\u76f8\u5bf9\u8d21\u732e\u53d6\u51b3\u4e8e\u764c\u75c7\u8c31\u7cfb\uff0c\u5e76\u4e14\u4e0e\u603b\u4f53\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u660e\u663e\u4e0d\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e8b\u5b9e\u4e0a\uff0c\u8bb8\u591a\u80bf\u7624\u7c7b\u578b\u6839\u636e\u8ba1\u7b97\u603b\u4f53TMB\u6216pTMB\u7684\u4e0d\u540c\u800c\u6539\u53d8\u5206\u7c7b\uff08\u4f4evs\u9ad8\u7a81\u53d8\u8d1f\u8377\uff09\u3002\u80bf\u7624\u975e\u6574\u500d\u6027\u548c\u6301\u4e45\u7a81\u53d8\u5728\u80bf\u7624\u7c7b\u578b\u4e4b\u95f4\u8868\u73b0\u51fa\u4e00\u7cfb\u5217\u5173\u7cfb\uff0c\u800c\u9a71\u52a8\u57fa\u56e0\u4e2d\u7684\u6301\u4e45\u7a81\u53d8\u5f88\u5c11\uff0c\u9664\u4e86tp53\u3002\u4e0e\u603b\u7a81\u53d8\u8d1f\u8377\u3001\u5bb9\u6613\u4e22\u5931\u7684\u7a81\u53d8\u8d1f\u8377\u6216\u80bf\u7624\u975e\u6574\u500d\u6027\u76f8\u6bd4\uff0c\u6301\u4e45\u7a81\u53d8\u8d1f\u8377\u66f4\u80fd\u533a\u5206\u5e94\u7b54\u60a3\u8005\u3002\u6301\u4e45\u7a81\u53d8\u5728\u80bf\u7624\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u6301\u7eed\u5b58\u5728\uff0c\u5177\u6709\u8f83\u9ad8pTMB\u7684\u80bf\u7624\u66f4\u5bb9\u6613\u53d1\u708e\uff0c\u4e0e\u7ec6\u80de\u6bd2\u6d3b\u6027\u548c\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u4e4b\uff0cAnagnostou\u6307\u51fa\uff0c\u7406\u89e3\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u57fa\u56e0\u7ec4\u8c03\u63a7\u662f\u5173\u952e\uff0c\u5e76\u53ef\u4ee5\u4e3a\u60a3\u8005\u7b5b\u9009\u7b56\u7565\u63d0\u4f9b\u6307\u5bfc\u3002TMB\u5e76\u4e0d\u80fd\u5b8c\u5168\u6355\u6349\u80bf\u7624\u7684\u5916\u6765\u6027\uff0c\u6301\u4e45\u7a81\u53d8\u4ee3\u8868\u4e86\u6574\u4f53TMB\u4e2d\u4e0d\u53ef\u7f16\u8f91\u7684\u4e00\u7ec4\uff0c\u4e0d\u4f1a\u88ab\u67d3\u8272\u4f53\u7f3a\u5931\u6216\u6cbb\u7597\u9009\u62e9\u538b\u529b\u6d88\u9664\u3002\u56e0\u6b64\uff0c\u6301\u4e45\u7a81\u53d8\u53ef\u80fd\u5bfc\u81f4\u66f4\u6301\u4e45\u7684\u65b0\u6297\u539f\u9a71\u52a8\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u4ece\u800c\u5728\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u5f97\u957f\u671f\u4e34\u5e8a\u6548\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.MEDI1191 \u8054\u5408\u5fb7\u74e6\u9c81\u5355\u6297\uff08D\uff09\u80bf\u7624\u5185\u7528\u836f\uff08IT\uff09\uff1a\u665a\u671f\u5b9e\u4f53\u7624\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u66f4\u65b0<\/strong><\/p>\n<\/section>\n

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Eduardo Casta\u00f1\u00f3n – Cl\u00ednica Universidad de Navarra, Pamplona, Spain<\/strong><\/p>\n<\/section>\n

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\u4e00\u79cd\u540d\u4e3aMEDI1191\u7684\u7f16\u7801IL-12\u7684mRNA\u8102\u8d28\u9897\u7c92\u5236\u5242\uff0c\u53ef\u901a\u8fc7\u80bf\u7624\u5185\uff08i.t.\uff09\u6ce8\u5c04\u4fc3\u8fdb\u5c40\u90e8IL-12\u4ea7\u751f\uff0c\u5e76\u589e\u5f3a\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u5148\u5929\u548c\u9002\u5e94\u6027CD8+ T\u7ec6\u80de\u4f9d\u8d56\u7684\u6297\u80bf\u7624\u514d\u75ab\u3002Eduardo Casta\u00f1\u00f3n\u5c55\u793a\u4e86\u4e00\u4e2a\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u7814\u7a76\u4e86\u80bf\u7624\u5185MEDI1191\u548c\u9759\u8109\uff08i.v.\uff09\u6297PD-1\uff08\u5fb7\u74e6\u9c81\u5355\u6297\uff09\u5728\u6cbb\u7597\u8fc7\u591a\u6b21\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u8054\u5408\u5e94\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5171\u670961\u540d\u60a3\u8005\u53c2\u52a0\u4e86\u8bd5\u9a8c\u3002\u5728\u5242\u91cf\u9012\u589e\u90e8\u52061A\uff0c\u76ae\u80a4\u6216\u76ae\u4e0b\u75c5\u53d8\u60a3\u8005\u5728\u7b2c1\u5929\u548c\u7b2c22\u5929\u63a5\u53d7MEDI1191\u6cbb\u7597\uff0c\u7136\u540e\u6bcf4\u5468\u63a5\u53d7\u4e00\u6b21\u5fb7\u74e6\u9c81\u5355\u6297\u6cbb\u7597\u3002\u57281B\u90e8\u5206\uff08\u76ae\u80a4\u6216\u76ae\u4e0b\u75c5\u53d8\u60a3\u8005\uff09\u548c1D\u90e8\u5206\uff08\u6df1\u90e8\u75c5\u53d8\u60a3\u8005\uff0c\u6240\u6709\u60c5\u51b5\u4e0b\u5747\u6709\u809d\u8f6c\u79fb\uff09\uff0c\u60a3\u8005\u5728\u7b2c1\u5929\u3001\u7b2c29\u5929\u548c\u7b2c57\u5929\u540c\u65f6\u63a5\u53d7MEDI1191\u548c\u675c\u74e6\u9c81\u80fa\u6cbb\u7597\uff0c\u7136\u540e\u6bcf4\u5468\u63a5\u53d7\u675c\u74e6\u9c81\u80fa\u6cbb\u7597\uff0c\u6bcf8\u5468\u63a5\u53d7MEDI1191\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6cbb\u7597\u6301\u7eed\u6700\u591a\u4e24\u5e74\uff0c\u6216\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u5fcd\u53d7\u7684\u6bd2\u6027\u3002\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u6216\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u75b2\u52b3\u548c\u53d1\u70ed\uff0c\u6700\u5e38\u89c1\u76843\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u662f\u8d2b\u8840\u3002\u5728\u6ce8\u5c04\u548c\u672a\u6ce8\u5c04\u7684\u5c40\u90e8\u6216\u8fdc\u7aef\u75c5\u53d8\u4e2d\u89c2\u5bdf\u5230\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8bc1\u5b9e\u4e86\u653e\u5c04\u72b6\u6548\u5e94\u3002\u5728\u672a\u6ce8\u5c04\u7684\u9776\u75c5\u53d8\u5904\u8fdb\u884c\u4e86\u53cd\u5e94\u8bc4\u4f30\u3002\u603b\u4f53\u53cd\u5e94\u7387\u4e3a8%\uff0c\u5176\u4e2d5\u4f8b\u8bc1\u5b9e\u4e3a\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0c\u5305\u62ec3\u4f8b\u5148\u524d\u63a5\u53d7\u8fc7\u6297PD-(L)1\u548c\/\u6216\u6297CTLA-4\u6cbb\u7597\u7684\u60a3\u8005\u300225%\u7684\u60a3\u8005\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\uff0c\u5176\u4e2d2\u4f8b\u672a\u8bc1\u5b9ePR\u3002\u53cd\u5e94\u6301\u7eed\u6700\u957f\u53ef\u8fbe22\u4e2a\u6708\uff0c\u4e2d\u4f4d\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u5c1a\u672a\u8fbe\u5230\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.\u5728PD-1\u8010\u836f\u80bf\u7624\u4e2d\u6fc0\u52a8\u5242\u5bf9\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n

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Elizabeth M. Jaffee – \u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\uff0c\u9a6c\u91cc\u5170\u5dde\u5df4\u5c14\u7684\u6469\u5e02<\/strong><\/p>\n<\/section>\n

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\u5728\u60a3\u8005\u4e2d\uff0c\u4e09\u8054\u7597\u6cd5\u662f\u672c\u7814\u7a76\u4e2d\u7b2c\u4e00\u4e2a\u8bf1\u5bfc\u75c5\u7406\u53cd\u5e94\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u5176\u4e2d10\u540d\u60a3\u8005\u4e2d\u67093\u540d\u8fbe\u5230\u8fd1\u5b8c\u5168\u7f13\u89e3\u3002\u4e2d\u4f4d\u65e0\u75c5\u751f\u5b58\u671f\u5c1a\u672a\u8fbe\u5230\uff0c\u8bb8\u591a\u60a3\u8005\u5df2\u7ecf\u4e24\u5e74\u4e86\u3002\u4ece\u6bcf\u4e2a\u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u514d\u75ab\u5e94\u7b54\u4e2d\u89c2\u5bdf\uff0c\u6bcf\u7ec4\u4e2d\u7684\u603bCD8+ T\u7ec6\u80de\u6570\u91cf\u9010\u6e10\u4e0a\u5347\u3002\u53e6\u4e00\u65b9\u9762\uff0cTregs\u5728\u7b2c\u4e8c\u7ec4\u4e2d\u589e\u52a0\uff0c\u4f46\u5728\u7b2c\u4e09\u7ec4\u4e2d\u968f\u7740\u6fc0\u52a8\u5242\u6297CD137\u7684\u6dfb\u52a0\u800c\u51cf\u5c11\u3002\u514b\u9686\u6269\u5f20\u968f\u7740\u6bcf\u4e2a\u6cbb\u7597\u7ec4\u7684\u589e\u52a0\u800c\u589e\u52a0\uff0c\u5728\u7b2c\u4e09\u7ec4\u4e2d\u89c2\u5bdf\u5230\u5927\u91cf\u7684\u9ad8\u5ea6\u6269\u5f20\u514b\u9686\u3002\u7b2c\u4e8c\u7ec4\u4e2d\uff0c\u8f6c\u8fd0\u3001\u8017\u7aed\u548c\u7ec6\u80de\u9aa8\u67b6\u91cd\u5851\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u7b2c\u4e09\u7ec4\u4e2d\u7ec6\u80de\u9aa8\u67b6\u91cd\u5851\u548c\u8d8b\u5316\u56e0\u5b50\/\u8f6c\u8fd0\u8fdb\u4e00\u6b65\u5bcc\u96c6\uff0c\u8fd9\u8868\u660e\u6d78\u6da6T\u7ec6\u80de\u7684\u8fd0\u52a8\u6027\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & AACR<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n

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\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/span><\/p>\n


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\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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