{"id":4944,"date":"2023-05-07T07:01:27","date_gmt":"2023-05-06T23:01:27","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/05\/07\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%94%ef%bc%9a%e9%ab%93%e7%b3%bb%e7%bb%86%e8%83%9e%e5%8f%8adc\/"},"modified":"2023-05-07T07:01:27","modified_gmt":"2023-05-06T23:01:27","slug":"2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%94%ef%bc%9a%e9%ab%93%e7%b3%bb%e7%bb%86%e8%83%9e%e5%8f%8adc","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/05\/07\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%94%ef%bc%9a%e9%ab%93%e7%b3%bb%e7%bb%86%e8%83%9e%e5%8f%8adc\/","title":{"rendered":"2023\u5e74\u5ea6\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\u4e94\uff1a\u9ad3\u7cfb\u7ec6\u80de\u53caDC\u76f8\u5173\u7597\u6cd5"},"content":{"rendered":"
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1.\u975e\u6297\u539f\u76f8\u5173\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u7597\u6cd5<\/strong><\/p>\n<\/section>\n

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Michele De Palma – \u745e\u58eb\u6d1b\u6851\u8054\u90a6\u7406\u5de5\u5b66\u9662 (EPFL)\uff0c\u6d1b\u6851\uff0c\u745e\u58eb<\/strong><\/p>\n<\/section>\n

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\u6811\u7a81\u72b6\u7ec6\u80de\u75ab\u82d7\u901a\u5e38\u7531\u8109\u51b2\u80bf\u7624\u88c2\u89e3\u7269\u6216\u80bf\u7624\u76f8\u5173\u6297\u539f\u7684\u5355\u6838\u7ec6\u80de\u6765\u6e90\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u5236\u6210\uff0c\u4f46\u8fd9\u7c7b\u75ab\u82d7\u7684\u4e34\u5e8a\u7597\u6548\u5f80\u5f80\u672a\u80fd\u8fbe\u5230\u9884\u671f\u3002Michele De Palma\u5047\u8bbe\uff0c\u8fd9\u53ef\u80fd\u4e0e\u6297\u539f\u7684\u4e0d\u5b8c\u5168\u8bc6\u522b\u548c\/\u6216\u4f7f\u7528\u5355\u6838\u7ec6\u80de\u6765\u6e90\u7684DCs\u6709\u5173\uff0c\u8fd9\u4e9bDCs\u5bb9\u6613\u4ece\u5355\u6838\u7ec6\u80de\u7956\u7ec6\u80de\u4e2d\u4ea7\u751f\uff0c\u4f46\u76f8\u6bd4\u4e13\u4e1a\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08\u5982cDC1s\uff09\u4ea4\u53c9\u5448\u9012\u80fd\u529b\u8f83\u5f31\uff0ccDC1s\u6765\u6e90\u4e8e\u5171\u540c\u7684DC\u7956\u7ec6\u80de\uff08DCP\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5047\u8bbeDCP\u53ef\u80fd\u662f\u6cbb\u7597\u6027DCs\u7684\u66f4\u597d\u6765\u6e90\uff0cDe Palma\u5f00\u53d1\u4e86\u4e00\u79cd\u4f7f\u7528\u7ec6\u80de\u56e0\u5b50\u6df7\u5408\u7269\u4ece\u9020\u8840\u5e72\u7ec6\u80de\u548c\u7956\u7ec6\u80de\uff08HSPCs\uff09\u4ea7\u751fDCPs\u7684\u65b9\u6cd5\u3002\u901a\u8fc7\u5c06DCPs\u79fb\u690d\u5230\u5c0f\u9f20\u540e\uff0c\u5b83\u4eec\u6210\u719f\u4e3a\u4ec5\u9650\u4e8e\u4e0d\u6210\u719fDCs\u3001cDC1s\u548ccDC2s\uff0c\u5e76\u6bd4\u5355\u6838\u7ec6\u80de\u6765\u6e90\u7684DCs\u66f4\u6709\u6548\u5730\u5d4c\u5165\u813e\u810f\u3002\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u7684\u603bcDC1\u548ccDC2\u7fa4\u4f53\uff08\u5305\u62ec\u5185\u6e90\u6027\u7ec6\u80de\uff09\u4e2d\uff0c\u591a\u8fbe50%\u7684cDC1\u6765\u81ea\u79fb\u690d\u7269\uff0c\u8fd9\u8868\u660eDCPs\u5373\u4f7f\u5728\u6ca1\u6709\u8c03\u8282\u7684\u60c5\u51b5\u4e0b\u4e5f\u80fd\u652f\u6301DC\u7684\u518d\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u540e\uff0cDe Palma\u63cf\u8ff0\u4e86\u4e00\u9879\u5b9e\u9a8c\uff0c\u5176\u4e2d\u5c06DCP-IL-12\/FLT3L\u4e0eGD2-CAR T\u7ec6\u80de\u8054\u5408\u5e94\u7528\u4e8e\u643a\u5e26GD2\u8868\u8fbe\u7684\u80f6\u8d28\u7624\u5c0f\u9f20\u3002\u5c3d\u7ba1DCP-IL-12\/FLT3L\u7ec6\u80de\u548cGD2-CAR T\u7ec6\u80de\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u5747\u65e0\u6548\uff0c\u4f46\u5b83\u4eec\u7684\u7ec4\u5408\u8bf1\u5bfc\u4e86\u5f3a\u70c8\u7684\u6297\u80bf\u7624\u53cd\u5e94\uff0c\u8bb8\u591a\u5c0f\u9f20\u7ecf\u5386\u4e86\u5b8c\u5168\u7f13\u89e3\u548c\u751f\u5b58\uff0c\u5373\u4f7f\u5728\u7ec6\u80de\u6c34\u5e73\u7684\u6210\u50cf\u4e2d\u4e5f\u672a\u68c0\u6d4b\u5230\u80f6\u8d28\u7624\u3002\u51ed\u501f\u8fd9\u4e9b\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u4f53\u5185\u7ed3\u679c\uff0cDe Palma\u5e0c\u671b\u8fd9\u79cd\u7b56\u7565\u80fd\u6210\u529f\u8f6c\u5316\u5230\u4e34\u5e8a\u5e94\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.\u9776\u5411\u80bf\u7624\u4e2d\u9ad3\u6837\u7ec6\u80de\u7684\u57fa\u7840\u548c\u4e34\u5e8a\u5f71\u54cd<\/strong><\/p>\n<\/section>\n

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Judith A. Varner – \u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff08UCSD\uff09Moores\u764c\u75c7\u4e2d\u5fc3\uff0cLa Jolla\uff0cCA<\/strong><\/p>\n<\/section>\n

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Varner\u53ca\u5176\u56e2\u961f\u9274\u5b9a\u51faPI3K\u03b3\uff0c\u56e0\u5176\u5728\u9ad3\u6837\u7ec6\u80de\u4e2d\u7684\u4e3b\u8981\u8868\u8fbe\u548c\u5728\u708e\u75c7\u8fc7\u7a0b\u4e2d\u9ad3\u6837\u7ec6\u80de\u52df\u96c6\u548c\u6781\u5316\u4e2d\u7684\u4f5c\u7528\u3002\u6291\u5236PI3K\u03b3\u53ef\u4fc3\u4f7f\u5de8\u566c\u7ec6\u80de\u5411M1\u8868\u578b\u6781\u5316\uff0c\u4e0e\u708e\u75c7\u548c\u6297\u539f\u5448\u9012\u76f8\u5173\u57fa\u56e0\u7684\u589e\u52a0\u548c\u514d\u75ab\u6291\u5236\u56e0\u5b50\u7f16\u7801\u57fa\u56e0\u7684\u8868\u8fbe\u51cf\u5c11\u6709\u5173\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cPI3K\u03b3\u6291\u5236\u6539\u53d8\u4e86\u5de8\u566c\u7ec6\u80de\u7684\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u5e76\u6539\u53d8\u4e86\u8f6c\u5f55\u3002\u5728\u8bb8\u591a\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u6cbb\u7597\u6027\u6291\u5236PI3K\u03b3\u51cf\u5c11\u4e86\u80bf\u7624\u751f\u957f\u548c\u8f6c\u79fb\uff0c\u4f46\u6548\u679c\u6839\u636e\u80bf\u7624\u5fae\u73af\u5883\u800c\u5f02\u3002\u708e\u75c7\u80bf\u7624\u53cd\u5e94\u66f4\u597d\uff0c\u4e0eT\u7ec6\u80de\u6fc0\u6d3b\u3001\u5148\u5929\u514d\u75ab\u548c\u6297\u539f\u5448\u9012\u76f8\u5173\u7684\u57fa\u56e0\u4e0a\u8c03\uff0c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u4e0aMHC II\u7c7b\u8868\u8fbe\u589e\u5f3a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e00\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cIPI-549\uff08eganelisib\uff09\uff0c\u4e00\u79cd\u9996\u521b\u53e3\u670dPI3K\u03b3\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u4e0enivolumab\u4f5c\u4e3a\u4e8c\u7ebf\u6cbb\u7597\u8054\u5408\u4f7f\u7528\uff0c\u5728\u665a\u671f\u987d\u56fa\u6027\u94c2\u7c7b\u8010\u836f\u6027\u8180\u80f1\u764c\u60a3\u8005\u4e2d\u964d\u4f4e\u4e8642%\u7684\u6b7b\u4ea1\u98ce\u9669\u3002\u5e94\u7b54\u60a3\u8005\u5728\u5916\u5468\u8840\u4e2d\u8868\u73b0\u51fa\u4e0e\u6297\u539f\u5448\u9012\u3001IFN\u03b3\u4fe1\u53f7\u548cTCR\u4fe1\u53f7\u76f8\u5173\u7684\u57fa\u56e0\u96c6\u5bcc\u96c6\uff0c\u8fd9\u4e0e\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u53d1\u73b0\u4e00\u81f4\u3002Varner\u53ca\u5176\u540c\u4e8b\u8fd8\u786e\u5b9a\u4e86Treg\u751f\u7269\u6807\u5fd7\u7269\u6574\u5408\u7d20\u03b28\uff08ITGB8\uff09\u4f5c\u4e3a\u4e00\u79cd\u6297\u6027\u56e0\u5b50\u3002\u5728\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0cCD4+ T\u7ec6\u80de\u9ad8\u5ea6\u8868\u8fbeITGB8\uff0c\u6291\u5236ITGB8\u548cPI3K\u03b3\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u534f\u540c\u7684\u6297\u80bf\u7624\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1.\u975e\u6297\u539f\u76f8\u5173\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u7597\u6cd5 Michele De Palma – \u745e\u58eb\u6d1b\u6851\u8054\u90a6\u7406\u5de5\u5b66\u9662 (EPFL)\uff0c\u6d1b\u6851\uff0c\u745e\u58eb \u6811\u7a81\u72b6\u7ec6\u80de\u75ab\u82d7\u901a\u5e38\u7531\u8109\u51b2\u80bf\u7624\u88c2\u89e3\u7269\u6216\u80bf\u7624\u76f8\u5173\u6297\u539f\u7684…<\/p>\n","protected":false},"author":1,"featured_media":4942,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[72],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/4944"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=4944"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/4944\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/4942"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=4944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=4944"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=4944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}