{"id":4974,"date":"2023-04-15T09:00:56","date_gmt":"2023-04-15T01:00:56","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/15\/monthly-updates-2023-03\/"},"modified":"2025-01-03T18:49:39","modified_gmt":"2025-01-03T10:49:39","slug":"monthly-updates-2023-03","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/15\/monthly-updates-2023-03\/","title":{"rendered":"Monthly Updates 2023.03"},"content":{"rendered":"
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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gut. 20230328<\/strong><\/p>\n<\/section>\n<\/section>\n

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FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer<\/strong><\/p>\n

\u805a\u96c6\u7d20\u6fc0\u9176\uff08FAK\uff09\u901a\u8fc7\u6291\u5236\u6297\u539f\u5904\u7406\u548c\u5448\u9012\u4fc3\u8fdb\u80f0\u817a\u764c\u514d\u75ab\u9003\u9038<\/strong><\/span><\/p>\n

Gut. 2023 Mar 28;gutjnl-2022-327927.<\/em><\/p>\n

doi: <\/strong>10.1136\/gutjnl-2022-327927.<\/p>\n

PubMed: <\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/36977556\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u76ee\u6807\uff1a<\/strong>\u514d\u75ab\u7597\u6cd5\u5bf9\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u7684\u6cbb\u7597\u4ec5\u663e\u793a\u51fa\u6709\u9650\u7684\u6548\u679c\u3002\u4f4eCD8 T\u7ec6\u80de\u6d78\u6da6\u3001\u4f4e\u65b0\u6297\u539f\u8d1f\u8377\u548c\u9ad8\u5ea6\u514d\u75ab\u6291\u5236\u7684\u80bf\u7624\u5fae\u73af\u5883\u90fd\u4f1a\u5bfc\u81f4\u53cd\u5e94\u7f3a\u4e4f\u3002\u5728\u6b64\uff0c\u6211\u4eec\u65e8\u5728\u8fdb\u4e00\u6b65\u7814\u7a76\u805a\u96c6\u7d20\u6fc0\u9176\uff08FAK\uff09\u5728PDAC\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u529f\u80fd\uff0c\u7279\u522b\u5f3a\u8c03\u5bf9II\u578b\u5e72\u6270\u7d20\u53cd\u5e94\u7684\u8c03\u8282\uff0c\u8be5\u53cd\u5e94\u5bf9\u4fc3\u8fdbT\u7ec6\u80de\u80bf\u7624\u8bc6\u522b\u548c\u6709\u6548\u7684\u514d\u75ab\u76d1\u89c6\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

\u8bbe\u8ba1\uff1a<\/strong>\u6211\u4eec\u5c06CRISPR\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u8f6c\u5f55\u7ec4\u5b66\u4e0e\u673a\u5236\u5b9e\u9a8c\u76f8\u7ed3\u5408\uff0c\u4f7f\u7528KrasG12Dp53R172H\u5c0f\u9f20\u80f0\u817a\u764c\u6a21\u578b\u8fdb\u884c\u7814\u7a76\uff0c\u5e76\u4f7f\u7528\u4eba\u6e90\u6027PDAC\u7ec6\u80de\u7cfb\u7684\u86cb\u767d\u8d28\u7ec4\u5206\u6790\u548c\u516c\u5f00\u53ef\u7528\u7684\u4eba\u7c7bPDAC\u8f6c\u5f55\u7ec4\u5b66\u6570\u636e\u96c6\u5206\u6790\u9a8c\u8bc1\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n

\u7ed3\u679c\uff1a<\/strong>PDAC\u7ec6\u80de\u5185\u5728\u7684FAK\u4fe1\u53f7\u4e27\u5931\u4fc3\u8fdb\u4e86\u514d\u75ab\u86cb\u767d\u9176\u4f53\u548c\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\u7c7bI\uff08MHC-I\uff09\u7684\u8868\u8fbe\uff0c\u5bfc\u81f4FAK-\/- PDAC\u7ec6\u80de\u7684\u6297\u539f\u591a\u6837\u6027\u548c\u6297\u539f\u5448\u9012\u589e\u52a0\u3002FAK\u5bf9\u514d\u75ab\u86cb\u767d\u9176\u4f53\u7684\u8c03\u8282\u662f\u6b64\u53cd\u5e94\u7684\u5173\u952e\u51b3\u5b9a\u56e0\u7d20\uff0c\u4f18\u5316\u4e86\u80bd\u6bb5\u5e93\u7684\u7269\u7406\u5316\u5b66\u7279\u6027\uff0c\u4f7f\u5176\u9ad8\u4eb2\u548c\u529b\u7ed3\u5408\u5230MHC-I\u4e0a\u3002\u901a\u8fc7FAK\u548cSTAT3\u7684\u5171\u540c\u8017\u7aed\uff0c\u8fd9\u4e9b\u901a\u8def\u7684\u8868\u8fbe\u53ef\u4ee5\u901a\u8fc7STAT1\u4f9d\u8d56\u7684\u65b9\u5f0f\u8fdb\u4e00\u6b65\u653e\u5927\uff0c\u5bfc\u81f4\u80bf\u7624\u53cd\u5e94\u6027CD8 T\u7ec6\u80de\u7684\u5e7f\u6cdb\u6d78\u6da6\u548c\u8fdb\u4e00\u6b65\u6291\u5236\u80bf\u7624\u751f\u957f\u3002FAK\u4f9d\u8d56\u7684\u6297\u539f\u5904\u7406\u548c\u5448\u9012\u7684\u8c03\u8282\u5728\u5c0f\u9f20\u548c\u4eba\u7c7bPDAC\u4e4b\u95f4\u662f\u4fdd\u5b88\u7684\uff0c\u4f46\u5728\u5177\u6709\u6781\u7aef\u9cde\u72b6\u8868\u578b\u7684\u7ec6\u80de\/\u80bf\u7624\u4e2d\u4e27\u5931\u4e86\u8fd9\u79cd\u8c03\u8282\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/strong>\u65e8\u5728\u964d\u89e3FAK\u7684\u6cbb\u7597\u65b9\u6cd5\u53ef\u80fd\u901a\u8fc7\u589e\u52a0\u6297\u539f\u591a\u6837\u6027\u548c\u4fc3\u8fdb\u6297\u539f\u5448\u9012\uff0c\u4e3aPDAC\u7684\u6cbb\u7597\u63d0\u4f9b\u989d\u5916\u7684\u6cbb\u7597\u76ca\u5904\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u6297\u539f\u5448\u9012\uff1b\u6297\u539f\u5904\u7406\uff1b\u7ec6\u80de\u9ecf\u9644\u5206\u5b50\uff1b\u514d\u75ab\u5e94\u7b54\uff1b\u80f0\u817a\u764c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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02<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Rev Cancer. 20230327<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nucleotide metabolism: a pan-cancer metabolic dependency<\/strong><\/p>\n

\u6838\u82f7\u9178\u4ee3\u8c22\uff1a\u4e00\u79cd\u6cdb\u764c\u4f9d\u8d56\u6027\u4ee3\u8c22<\/strong><\/span><\/p>\n

Nat Rev Cancer. 2023 Mar 27;1-20.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41568-023-00557-7.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36973407\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Exp Med. 20230330<\/strong><\/p>\n<\/section>\n<\/section>\n

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Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages<\/strong><\/p>\n

\u541e\u566c\u4f5c\u7528\u589e\u52a0\u4e86\u80bf\u7624\u5de8\u566c\u7ec6\u80de\u7684\u6c27\u5316\u4ee3\u8c22\u548c\u514d\u75ab\u6291\u5236\u7279\u5f81<\/strong><\/span><\/p>\n

J Exp Med. 2023 Jun 5;220(6):e20221472.<\/em><\/p>\n

doi: <\/strong>10.1084\/jem.20221472.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36995340\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

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04<\/strong><\/p>\n<\/section>\n<\/section>\n

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Genome Med. 20230317<\/strong><\/p>\n<\/section>\n<\/section>\n

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spSeudoMap: cell type mapping of spatial transcriptomics using unmatched single-cell RNA-seq data<\/strong><\/p>\n

spSeudoMap: \u5229\u7528\u4e0d\u5339\u914d\u7684\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e\u8fdb\u884c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u7684\u7ec6\u80de\u7c7b\u578b\u6620\u5c04<\/strong><\/span><\/p>\n

Genome Med. 2023 Mar 17;15(1):19.<\/em><\/p>\n

doi: <\/strong>10.1186\/s13073-023-01168-5.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36932388\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7531\u4e8e\u8bb8\u591a\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u6570\u636e\u662f\u5728\u7ec6\u80de\u5206\u9009\u540e\u83b7\u5f97\u7684\uff0c\u4f8b\u5982\u5728\u7814\u7a76\u514d\u75ab\u7ec6\u80de\u65f6\uff0c\u5c06\u5355\u7ec6\u80de\u6570\u636e\u4e0e\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u6570\u636e\u96c6\u6210\u4ee5\u8ddf\u8e2a\u7ec6\u80de\u666f\u89c2\u7684\u9650\u5236\u5728\u4e8e\u4e24\u4e2a\u6570\u636e\u96c6\u4e4b\u95f4\u7684\u7ec6\u80de\u7c7b\u578b\u548c\u7ec6\u80de\u7ec4\u6210\u4e0d\u5339\u914d\u3002\u6211\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u65b9\u6cd5\uff0c\u79f0\u4e3aspSeudoMap\uff0c\u5229\u7528\u6392\u5e8f\u540e\u7684scRNA-seq\u6570\u636e\u521b\u5efa\u6a21\u62df\u7a7a\u95f4\u6570\u636e\u57fa\u56e0\u8868\u8fbe\u76f8\u4f3c\u7684\u865a\u62df\u7ec6\u80de\u6df7\u5408\u7269\uff0c\u5e76\u8bad\u7ec3\u9886\u57df\u9002\u5e94\u6a21\u578b\u6765\u9884\u6d4b\u7a7a\u95f4\u7ec6\u80de\u7ec4\u6210\u3002\u8be5\u65b9\u6cd5\u5e94\u7528\u4e8e\u8111\u90e8\u548c\u4e73\u817a\u764c\u7ec4\u7ec7\u4e2d\uff0c\u5e76\u51c6\u786e\u9884\u6d4b\u4e86\u7ec6\u80de\u4e9a\u7fa4\u7684\u62d3\u6251\u3002spSeudoMap\u53ef\u4ee5\u5e2e\u52a9\u9610\u660e\u4e00\u4e9b\u81f3\u5173\u91cd\u8981\u7684\u7ec6\u80de\u7c7b\u578b\u7684\u4f5c\u7528\u3002<\/p>\n

Keywords:<\/strong><\/span><\/p>\n

\u7ec6\u80de\u5206\u9009\uff1b\u7ec6\u80de\u7c7b\u578b\u6620\u5c04\uff1b\u4f2a\u5757\uff1b\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff1b\u7a7a\u95f4\u8f6c\u5f55\u7ec4\uff1b\u5408\u6210\u7ec6\u80de\u6df7\u5408\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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05<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Discov. 20230322<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer<\/strong><\/p>\n

\u7ec6\u80de\u81ea\u4e3b\u6027Cxcl1\u901a\u8fc7\u4e2d\u6027\u7c92\u7ec6\u80de\u6765\u6e90\u7684TNF\u5728\u80f0\u817a\u764c\u4e2d\u7ef4\u6301\u8010\u53d7\u6027\u56de\u8def\u548c\u57fa\u8d28\u708e\u75c7<\/strong><\/span><\/p>\n

Cancer Discov. 2023 Mar 22;CD-22-1046.<\/em><\/p>\n

doi: <\/strong>10.1158\/2159-8290.CD-22-1046.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36946782\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u6211\u4eec\u5df2\u7ecf\u8bc1\u660eKRAS-TP53\u57fa\u56e0\u7ec4\u5171\u540c\u53d8\u5f02\u4e0e\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u7684\u514d\u75ab\u6392\u9664\u5fae\u73af\u5883\u3001\u5316\u7597\u6297\u6027\u548c\u4e0d\u826f\u751f\u5b58\u6709\u5173\u3002\u901a\u8fc7\u5c06KRAS-TP53\u5408\u4f5c\u4f5c\u4e3a\u9ad8\u98ce\u9669\u751f\u7269\u5b66\u7684\u6a21\u578b\uff0c\u6211\u4eec\u73b0\u5728\u4f7f\u7528\u6210\u50cf\u8d28\u8c31\u7ec6\u80de\u5b66\u6280\u672f\u5728\u4eba\u7c7bPDAC\u4e2d\u786e\u5b9a\u4e86\u7ec6\u80de\u81ea\u4e3b\u6027Cxcl1\u4f5c\u4e3a\u7a7a\u95f4T\u7ec6\u80de\u9650\u5236\u7684\u5173\u952e\u4ecb\u8d28\uff0c\u901a\u8fc7\u4e0eCXCR2+\u4e2d\u6027\u7c92\u7ec6\u80de\u6765\u6e90\u7684\u9ad3\u6837\u6291\u5236\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002\u6c89\u9ed8\u7ec6\u80de\u5185Cxcl1\u53ef\u4ee5\u91cd\u65b0\u7f16\u7a0b\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u8f6c\u8fd0\u548c\u529f\u80fd\u52a8\u6001\uff0c\u4ee5\u514b\u670dT\u7ec6\u80de\u6392\u9664\uff0c\u5e76\u4ee5T\u7ec6\u80de\u4f9d\u8d56\u7684\u65b9\u5f0f\u63a7\u5236\u80bf\u7624\u751f\u957f\u3002\u5728\u673a\u5236\u4e0a\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u6765\u6e90\u7684TNF\u662f\u514d\u75ab\u91cd\u6784\u7684\u4e2d\u5fc3\u8c03\u8282\u56e0\u5b50\uff0c\u901a\u8fc7\u8de8\u819cTNF-TNFR2\u76f8\u4e92\u4f5c\u7528\u5f15\u53d1\u80bf\u7624\u7ec6\u80de\u548c\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAF\uff09\u7684\u53cd\u9988\u6027Cxcl1\u8fc7\u5ea6\u4ea7\u751f\u3001T\u7ec6\u80de\u529f\u80fd\u969c\u788d\u548c\u708e\u6027CAF\u6781\u5316\u3002TNFR2\u6291\u5236\u53ef\u4ee5\u7834\u574f\u8fd9\u79cd\u56de\u8def\u5e76\u63d0\u9ad8\u5bf9\u5316\u7597\u7684\u654f\u611f\u6027\u3002\u6211\u4eec\u7684\u7ed3\u679c\u63ed\u793a\u4e86\u764c\u7ec6\u80de-\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5176\u4e2d\u4f9d\u8d56\u4e8e\u73af\u5883\u4e2d\u7684TNF\u4fe1\u53f7\u653e\u5927\u57fa\u8d28\u708e\u75c7\u548c\u514d\u75ab\u8010\u53d7\uff0c\u4ee5\u4fc3\u8fdbPDAC\u6cbb\u7597\u6297\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Exp Med. 20230323<\/strong><\/p>\n<\/section>\n<\/section>\n

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Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy<\/strong><\/p>\n

\u57fa\u8d28\u548c\u6cbb\u7597\u8bf1\u5bfc\u7684\u5de8\u566c\u7ec6\u80de\u589e\u6b96\u4fc3\u8fdbPDAC\u8fdb\u5c55\u548c\u5148\u5929\u514d\u75ab\u6cbb\u7597\u7684\u6613\u611f\u6027<\/strong><\/span><\/p>\n

J Exp Med. 2023 Jun 5;220(6):e20212062.<\/em><\/p>\n

doi: <\/strong>10.1084\/jem.20212062.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36951731\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u5728\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u4e2d\u975e\u5e38\u4e30\u5bcc\u3002\u867d\u7136\u5df2\u77e5TAM\u4f1a\u5728\u764c\u7ec4\u7ec7\u4e2d\u589e\u6b96\uff0c\u4f46\u8fd9\u5bf9\u5de8\u566c\u7ec6\u80de\u8868\u578b\u548c\u75be\u75c5\u8fdb\u5c55\u7684\u5f71\u54cd\u5c1a\u4e0d\u6e05\u695a\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u5728PDAC\u4e2d\uff0cTAM\u7684\u589e\u6b96\u53ef\u4ee5\u7531\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4ea7\u751f\u7684\u96c6\u843d\u523a\u6fc0\u56e0\u5b50-1\uff08CSF1\uff09\u9a71\u52a8\u3002CSF1\u8bf1\u5bfc\u5de8\u566c\u7ec6\u80de\u4e2d\u9ad8\u6c34\u5e73\u7684p21\uff0c\u8be5\u86cb\u767d\u8c03\u8282TAM\u7684\u589e\u6b96\u548c\u8868\u578b\u3002\u8868\u8fbe\u9ad8\u6c34\u5e73p21\u7684\u4eba\u7c7b\u548c\u5c0f\u9f20PDAC\u4e2d\u7684TAM\u5177\u6709\u66f4\u591a\u7684\u708e\u6027\u548c\u514d\u75ab\u6291\u5236\u8868\u578b\u3002TAM\u4e2dp21\u7684\u8868\u8fbe\u53d7\u5230\u57fa\u8d28\u76f8\u4e92\u4f5c\u7528\u548c\/\u6216\u5316\u7597\u6cbb\u7597\u7684\u8bf1\u5bfc\u3002\u6700\u540e\uff0c\u901a\u8fc7\u6a21\u62dfTAM\u4e2dp21\u8868\u8fbe\u6c34\u5e73\uff0c\u6211\u4eec\u53d1\u73b0p21\u9a71\u52a8\u7684\u5de8\u566c\u7ec6\u80de\u514d\u75ab\u6291\u5236\u5728\u4f53\u5185\u63a8\u52a8\u4e86\u80bf\u7624\u8fdb\u5c55\u3002\u4ee4\u4eba\u60ca\u559c\u7684\u662f\uff0c\u9a71\u52a8\u80bf\u7624\u8fdb\u5c55\u7684\u76f8\u540cp21\u901a\u8def\u4e5f\u4fc3\u8fdb\u4e86\u5bf9CD40\u6fc0\u52a8\u5242\u7684\u53cd\u5e94\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u57fa\u8d28\u6216\u6cbb\u7597\u5f15\u8d77\u7684\u7ec6\u80de\u5468\u671f\u673a\u5236\u7684\u8c03\u8282\u53ef\u4ee5\u8c03\u8282\u5de8\u566c\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u548c\u5148\u5929\u514d\u75ab\u6cbb\u7597\u7684\u6613\u611f\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Immunol. 20230317<\/strong><\/p>\n<\/section>\n<\/section>\n

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Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer<\/strong><\/p>\n

\u9776\u5411\u67d3\u8272\u8d28\u6548\u5e94\u56e0\u5b50Pygo2\u4fc3\u8fdb\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u53cd\u5e94\u5e76\u514b\u670d\u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\u6297\u6027<\/strong><\/span><\/p>\n

Sci Immunol. 2023 Mar 17;8(81):eade4656.<\/em><\/p>\n

doi: <\/strong>10.1126\/sciimmunol.ade4656.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36897957\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u524d\u5217\u817a\u764c\u4e2d\u7684\u975e\u708e\u6027\u5fae\u73af\u5883\u4ee3\u8868\u4e86\u514d\u75ab\u6cbb\u7597\u7684\u969c\u788d\u3002\u8d8a\u6765\u8d8a\u591a\u5730\u8ba4\u8bc6\u5230\uff0c\u764c\u7ec6\u80de\u5185\u5728\u7684\u81f4\u764c\u4fe1\u53f7\u9057\u4f20\u53d8\u5f02\u5728\u5851\u9020\u514d\u75ab\u666f\u89c2\u4e2d\u7684\u4f5c\u7528\u3002\u6700\u8fd1\uff0c\u6211\u4eec\u786e\u5b9a\u4e86Pygopus 2\uff08PYGO2\uff09\u4f5c\u4e3a\u524d\u5217\u817a\u764c1q21.3\u6269\u589e\u4f53\u4e2d\u7684\u9a71\u52a8\u81f4\u764c\u57fa\u56e0\u3002\u5728\u8f6c\u79fb\u6027\u524d\u5217\u817a\u817a\u764c\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0Pygo2\u7684\u7f3a\u5931\u53ef\u4ee5\u51cf\u7f13\u80bf\u7624\u8fdb\u5c55\u3001\u51cf\u5c11\u8f6c\u79fb\u5e76\u5ef6\u957f\u751f\u5b58\u65f6\u95f4\u3002Pygo2\u7684\u7f3a\u5931\u589e\u5f3a\u4e86\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u7684\u6fc0\u6d3b\u548c\u6d78\u6da6\uff0c\u5e76\u4f7f\u80bf\u7624\u7ec6\u80de\u5bf9T\u7ec6\u80de\u6740\u4f24\u66f4\u654f\u611f\u3002\u673a\u5236\u4e0a\uff0cPygo2\u534f\u540cp53\/Sp1\/Kit\/Ido1\u4fe1\u53f7\u7f51\u7edc\uff0c\u4fc3\u8fdb\u5bf9CTL\u4e0d\u5229\u7684\u5fae\u73af\u5883\u3002\u9057\u4f20\u6216\u836f\u7269\u6291\u5236Pygo2\u53ef\u589e\u5f3a\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u3001\u514d\u75ab\u7ec6\u80de\u8f6c\u79fb\u6216\u6291\u5236\u9ad3\u6837\u6291\u5236\u7ec6\u80de\u7684\u836f\u7269\u7684\u6297\u80bf\u7624\u7597\u6548\u3002\u5728\u4eba\u7c7b\u524d\u5217\u817a\u764c\u6837\u672c\u4e2d\uff0cPygo2\u7684\u8868\u8fbe\u4e0eCD8+ T\u7ec6\u80de\u7684\u6d78\u6da6\u5448\u8d1f\u76f8\u5173\u3002ICB\u4e34\u5e8a\u6570\u636e\u5206\u6790\u663e\u793a\uff0c\u9ad8PYGO2\u6c34\u5e73\u4e0e\u8f83\u5dee\u7684\u9884\u540e\u6709\u5173\u3002\u7efc\u4e0a\uff0c\u6211\u4eec\u7684\u7ed3\u679c\u5f3a\u8c03\u4e86\u4f7f\u7528\u4ee5Pygo2\u4e3a\u9776\u70b9\u7684\u6cbb\u7597\u6539\u5584\u665a\u671f\u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\u7684\u6f5c\u5728\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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08<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230313-1<\/strong><\/p>\n<\/section>\n<\/section>\n

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The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth<\/strong><\/p>\n

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Cancer Cell. 2023 Mar 13;41(3):374-403.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.02.016.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36917948\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u75c7\u4ee3\u8868\u7740\u4e00\u4e2a\u590d\u6742\u7684\u751f\u6001\u7cfb\u7edf\uff0c\u5305\u62ec\u80bf\u7624\u7ec6\u80de\u548c\u5927\u91cf\u7684\u975e\u764c\u7ec6\u80de\uff0c\u5d4c\u5165\u5728\u6539\u53d8\u7684\u7ec6\u80de\u5916\u57fa\u8d28\u4e2d\u3002\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u5305\u62ec\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u3001\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u3001\u5468\u76ae\u7ec6\u80de\u4ee5\u53ca\u5176\u4ed6\u5404\u79cd\u7ec4\u7ec7\u9a7b\u7559\u7ec6\u80de\u7c7b\u578b\u3002\u8fd9\u4e9b\u5bbf\u4e3b\u7ec6\u80de\u66fe\u7ecf\u88ab\u8ba4\u4e3a\u662f\u80bf\u7624\u53d1\u751f\u7684\u65c1\u89c2\u8005\uff0c\u4f46\u73b0\u5728\u5df2\u77e5\u5b83\u4eec\u5728\u764c\u75c7\u7684\u53d1\u75c5\u673a\u5236\u4e2d\u626e\u6f14\u7740\u81f3\u5173\u91cd\u8981\u7684\u89d2\u8272\u3002TME\u7684\u7ec6\u80de\u7ec4\u6210\u548c\u529f\u80fd\u72b6\u6001\u53ef\u4ee5\u6839\u636e\u80bf\u7624\u53d1\u751f\u7684\u5668\u5b98\u3001\u764c\u7ec6\u80de\u7684\u5185\u5728\u7279\u5f81\u3001\u80bf\u7624\u9636\u6bb5\u548c\u60a3\u8005\u7279\u5f81\u800c\u6709\u6240\u4e0d\u540c\u3002\u5728\u672c\u6587\u4e2d\uff0c\u6211\u4eec\u56de\u987e\u4e86TME\u5728\u764c\u75c7\u8fdb\u5c55\u7684\u6bcf\u4e2a\u9636\u6bb5\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u5305\u62ec\u80bf\u7624\u7684\u8d77\u59cb\u3001\u8fdb\u5c55\u3001\u4fb5\u88ad\u548c\u7a7f\u900f\uff0c\u4ee5\u53ca\u8f6c\u79fb\u6269\u6563\u548c\u751f\u957f\u3002\u4e86\u89e3\u80bf\u7624\u7ec6\u80de\u5185\u5728\u3001\u7ec6\u80de\u5916\u548c\u7cfb\u7edf\u4ecb\u8d28\u5728\u75be\u75c5\u8fdb\u5c55\u4e2d\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u5bf9\u4e8e\u5408\u7406\u5f00\u53d1\u6709\u6548\u7684\u6297\u764c\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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09<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230313-2<\/strong><\/p>\n<\/section>\n<\/section>\n

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Activated fibroblasts in cancer: Perspectives and challenges<\/strong><\/p>\n

\u764c\u75c7\u4e2d\u7684\u6d3b\u5316\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1a\u5c55\u671b\u548c\u6311\u6218<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Mar 13;41(3):434-449.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.02.015.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36917949\/<\/span><\/p>\n

Abstract<\/strong><\/p>\n

\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u80bf\u7624\u4e2d\u7684\u6d3b\u5316\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u6216\u79f0\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\uff0c\u5df2\u6210\u4e3a\u70ed\u95e8\u7814\u7a76\u9886\u57df\u3002\u4f5c\u4e3a\u80bf\u7624\u751f\u7269\u5b66\u7684\u91cd\u8981\u53c2\u4e0e\u8005\uff0cCAFs \u7684\u529f\u80fd\u8303\u56f4\u4ece\u80f6\u539f\u6c89\u79ef\u5230\u514d\u75ab\u6291\u5236\uff0c\u5176\u5df2\u6210\u4e3a\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u76ee\u6807\uff0c\u63ed\u793a\u4e86\u5176\u6f5c\u5728\u7684\u6297\u80bf\u7624\u548c\u4fc3\u80bf\u7624\u4f5c\u7528\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u63cf\u8ff0\u4e86 CAFs \u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u4ee5\u53ca\u4f7f\u8fd9\u4e9b\u53d1\u73b0\u6210\u4e3a\u53ef\u80fd\u7684\u6280\u672f\u8fdb\u5c55\uff0c\u5e76\u8be6\u7ec6\u4ecb\u7ecd\u4e86\u76ee\u524d\u53ef\u7528\u4e8e CAF \u7814\u7a76\u7684\u6a21\u578b\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5448\u73b0\u652f\u6301\u5c06 CAF \u7814\u7a76\u4f5c\u4e3a\u672a\u6765\u6cbb\u7597\u9014\u5f84\u7684\u8bc1\u636e\uff0c\u540c\u65f6\u5f3a\u8c03\u5fc5\u987b\u89e3\u51b3\u7684\u6311\u6218\uff0c\u4ee5\u6210\u529f\u5730\u5c06\u65b0\u53d1\u73b0\u4e34\u5e8a\u8f6c\u5316\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u6d3b\u5316\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1b\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1b\u57fa\u8d28\uff1b\u80bf\u7624\u5fae\u73af\u5883<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230313-3<\/strong><\/p>\n<\/section>\n<\/section>\n

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Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy<\/strong><\/p>\n

\u80bf\u7624\u6d78\u6da6\u6027\u8c03\u8282\u6027T\u7ec6\u80de\u4f5c\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u9776\u70b9<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Mar 13;41(3):450-465.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.02.014.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36917950\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5b58\u5728\u4e30\u5bcc\uff0c\u8fd9\u5f15\u53d1\u4e86\u4e00\u4e2a\u95ee\u9898\uff0c\u5373\u662f\u5426\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u6d88\u9664\u6216\u51cf\u5f31\u514d\u75ab\u6291\u5236\u7684\u80bf\u7624\u6d78\u6da6\u6027Tregs\uff08TI-Tregs\uff09\uff0c\u4ee5\u6fc0\u53d1\u5e38\u89c4T\u7ec6\u80de\uff08Tconvs\uff09\u6709\u6548\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u800c\u4e0d\u6270\u4e71\u5065\u5eb7\u5668\u5b98\u4e2d\u7684Treg\u4f9d\u8d56\u6027\u514d\u75ab\u7a33\u6001\u800c\u5f15\u8d77\u81ea\u8eab\u514d\u75ab\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u56de\u987e\u4e86\u5f53\u524d\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u7b56\u7565\uff0c\u5305\u62ec\u9488\u5bf9CTLA-4\u548cPD-1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u6ede\uff08ICB\uff09\u6297\u4f53\uff0c\u5e76\u8ba8\u8bba\u5b83\u4eec\u5bf9TI-Tregs\u7684\u5f71\u54cd\u3002\u6211\u4eec\u8fd8\u8ba8\u8bba\u4e86\u5229\u7528TI-Tregs\u548cTconvs\u4e4b\u95f4\u7ec6\u80de\u8868\u9762(\u5982CTLA-4)\u548c\u7ec6\u80de\u5185(\u5982T\u7ec6\u80de\u53d7\u4f53\u4fe1\u53f7\u5206\u5b50)\u5dee\u5f02\u8c03\u8282\u5206\u5b50\u7684\u65b9\u6cd5\uff0c\u4ee5\u53ca\u5b83\u4eec\u5bf9\u7ec6\u80de\u56e0\u5b50(\u5982IL-2)\u548c\u4ee3\u8c22\u4ea7\u7269(\u5982\u4e73\u9178)\u7684\u4f9d\u8d56\u6027\u3002\u6211\u4eec\u9884\u89c1\uff0c\u9488\u5bf9TI-Tregs\u7684\u6cbb\u7597\u53ef\u80fd\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u6216\u4e0eICB\u6297\u4f53\u8054\u5408\u4f7f\u7528\u662f\u6709\u6548\u7684\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u8c03\u8282\u6027T\u7ec6\u80de\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\uff1b\u514d\u75ab\u6291\u5236\uff1b\u514d\u75ab\u6cbb\u7597\uff1b\u80bf\u7624\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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11<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230313-4<\/strong><\/p>\n<\/section>\n<\/section>\n

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B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity<\/strong><\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684B\u7ec6\u80de\uff1a\u6297\u80bf\u7624\u514d\u75ab\u7684\u591a\u65b9\u4f4d\u7ec4\u7ec7\u8005\u3001\u8c03\u8282\u8005\u548c\u6267\u884c\u8005<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Mar 13;41(3):466-489.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.02.017.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36917951\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u6211\u4eec\u5bf9\u6d78\u6da6\u80bf\u7624\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u7684\u7406\u89e3\u6b63\u5728\u8fc5\u901f\u6269\u5c55\uff0c\u4e0d\u518d\u4ec5\u9650\u4e8eT\u7ec6\u80de\u4e3a\u4e2d\u5fc3\u7684\u89c2\u70b9\uff0c\u800c\u662f\u5305\u62ecB\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\uff0c\u7edf\u79f0\u4e3aTIL-B\u3002\u5728\u8bb8\u591a\u764c\u75c7\u4e2d\uff0cTIL-B\u5177\u6709\u5f3a\u70c8\u7684\u9884\u540e\u610f\u4e49\uff0c\u5e76\u6b63\u5728\u6210\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53cd\u5e94\u7684\u5173\u952e\u9884\u6d4b\u56e0\u5b50\u3002TIL-B\u53ef\u4ee5\u6267\u884c\u591a\u79cd\u529f\u80fd\uff0c\u5305\u62ec\u6297\u539f\u5448\u9012\u548c\u6297\u4f53\u4ea7\u751f\uff0c\u4f7f\u5b83\u4eec\u80fd\u591f\u5c06\u514d\u75ab\u53cd\u5e94\u96c6\u4e2d\u4e8e\u8bc6\u522b\u6297\u539f\uff0c\u4ee5\u652f\u6301T\u7ec6\u80de\u53cd\u5e94\u548c\u6d89\u53ca\u4e92\u8865\u3001\u5de8\u566c\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u7684\u5148\u5929\u514d\u75ab\u673a\u5236\u3002\u5728\u514d\u75ab\u5b66\u4e0a\u6700\u201c\u70ed\u201d\u7684\u80bf\u7624\u7684\u57fa\u8d28\u4e2d\uff0cTIL-B\u662f\u7b2c\u4e09\u7c7b\u6dcb\u5df4\u7ed3\u6784\u7684\u7a81\u51fa\u7ec4\u5206\uff0c\u5176\u5728\u7ed3\u6784\u4e0a\u548c\u529f\u80fd\u4e0a\u7c7b\u4f3c\u4e8e\u6dcb\u5df4\u7ed3\u3002\u6b64\u5916\uff0cTIL-B\u53c2\u4e0e\u5404\u79cd\u5176\u4ed6\u6dcb\u5df4-\u9aa8\u9ad3\u805a\u96c6\u4f53\uff0c\u5e76\u4e0e\u80bf\u7624\u57fa\u8d28\u8fdb\u884c\u52a8\u6001\u4e92\u52a8\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u603b\u7ed3\u4e86\u6211\u4eec\u5bf9\u4eba\u7c7b\u764c\u75c7\u4e2dTIL-B\u7684\u7406\u89e3\uff0c\u5f3a\u8c03\u4e86\u5176\u72ec\u7279\u7684\u80bf\u7624\u8bc6\u522b\u548c\u6548\u5e94\u673a\u5236\u6240\u63d0\u4f9b\u7684\u5f15\u4eba\u6ce8\u76ee\u7684\u6cbb\u7597\u673a\u4f1a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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12<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230313-5<\/strong><\/p>\n<\/section>\n<\/section>\n

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Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment<\/strong><\/p>\n

\u80bf\u7624PD-L1\u901a\u8fc7\u7ed3\u5408\u9ad3\u7cfbPD-1\u6765\u6291\u5236\u2160\u578b\u5e72\u6270\u7d20\u3001\u524a\u5f31\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u62db\u52df<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Mar 13;41(3):620-636.e9.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.02.005.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36917954\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80bf\u7624\u7ec6\u80dePD-L1\uff08tPD-L1\uff09\u5728\u80bf\u7624\u514d\u75ab\u9003\u9038\u4e2d\u7684\u7ec6\u80de\u548c\u5206\u5b50\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u7406\u89e3\u3002\u6211\u4eec\u53d1\u73b0\uff0ctPD-L1\u5728\u80bf\u7624\u7ec6\u80de\u548c\u80bf\u7624\u7279\u5f02\u6027CTL\u7684\u5171\u57f9\u517b\u4e2d\u4e0d\u6291\u5236\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u6d3b\u6027\uff0c\u5bf9\u539f\u53d1\u6027\u80bf\u7624\u751f\u957f\u4e5f\u6ca1\u6709\u5f71\u54cd\u3002\u7136\u800c\uff0c\u6e05\u9664tPD-L1\u4f1a\u4ee5CTL\u4f9d\u8d56\u7684\u65b9\u5f0f\u964d\u4f4e\u80bf\u7624\u643a\u5e26\u5c0f\u9f20\u7684\u80ba\u8f6c\u79fb\u3002\u9ad3\u7cfb\u7ec6\u80de\u7684\u8017\u5c3d\u6216\u9ad3\u7cfbPD-1\uff08mPD-1\uff09\u7684\u6572\u9664\u4f1a\u524a\u5f31tPD-L1\u4fc3\u8fdb\u80bf\u7624\u80ba\u8f6c\u79fb\u7684\u4f5c\u7528\u3002\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u663e\u793a\uff0ctPD-L1\u4e0emPD-1\u4e92\u76f8\u7ed3\u5408\uff0c\u6fc0\u6d3bSHP2\u5bf9\u6297\u2160\u578b\u5e72\u6270\u7d20\uff08IFN-I\uff09\u548cSTAT1\u9014\u5f84\uff0c\u6291\u5236Cxcl9\u5e76\u635f\u5bb3CTL\u5728\u80ba\u8f6c\u79fb\u7076\u7684\u62db\u52df\u3002\u4eba\u7c7b\u764c\u75c7\u60a3\u8005\u5bf9PD-1\u963b\u65ad\u514d\u75ab\u7597\u6cd5\u7684\u53cd\u5e94\u4e0e\u9ad3\u7cfb\u7ec6\u80de\u7684IFN-I\u53cd\u5e94\u76f8\u5173\u3002\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u786e\u5b9a\u4e86tPD-L1\u901a\u8fc7\u7ed3\u5408mPD-1\u6fc0\u6d3bSHP2\u6765\u6291\u5236IFN-I-STAT1-CXCL9\u9014\u5f84\uff0c\u4ece\u800c\u635f\u5bb3CTL\u5728\u80ba\u8f6c\u79fb\u80bf\u7624\u4e2d\u7684\u62db\u52df\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CTL\uff1bCXCL9\uff1bPD-1\uff1bPD-L1\uff1bSHP2\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u6ede\uff1b\u80ba\u8f6c\u79fb\uff1b\u2160\u578b\u5e72\u6270\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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13<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gastroenterology. 20230313<\/strong><\/p>\n<\/section>\n<\/section>\n

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Single-cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-ring Cell Carcinoma<\/strong><\/p>\n

\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u7684\u5355\u7ec6\u80de\u5206\u6790\u63ed\u793a\u80c3\u7c98\u6db2\u817a\u764c\u4e2d\u7684\u514d\u75ab\u4e0d\u5e94\u6027<\/strong><\/span><\/p>\n

Gastroenterology. 2023 Mar 13;S0016-5085(23)00262-7. <\/em><\/p>\n

doi: <\/strong>10.1053\/j.gastro.2023.03.008.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36921674\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80cc\u666f\u548c\u76ee\u7684\uff1a<\/strong>\u80c3\u764c\uff08GC\uff09\u662f\u4e00\u79cd\u4e3b\u8981\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u5176\u7279\u5f81\u662f\u80bf\u7624\u7ec6\u80de\u548c\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff08TIME\uff09\u7684\u9ad8\u5f02\u8d28\u6027\u3002\u80c3\u7c98\u6db2\u817a\u764c\uff08GSRCC\uff09\u662f\u4e00\u79cd\u96be\u4ee5\u6cbb\u7597\u7684GC\u4e9a\u578b\uff0c\u901a\u5e38\u4e0e\u4e0d\u826f\u9884\u540e\u76f8\u5173\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695aGSRCC\u7684TIME\u7279\u5f81\u4ee5\u53ca\u8fd9\u4e9b\u7279\u5f81\u5982\u4f55\u5f71\u54cd\u4e34\u5e8a\u7ed3\u679c\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/strong>\u6211\u4eec\u62db\u52df\u4e8632\u540d\u4e0d\u540c\u4e9a\u578b\u665a\u671fGC\u60a3\u8005\uff0c\u5e76\u4f7f\u7528\u514d\u75ab\u5b9a\u5411\u5355\u7ec6\u80de\u5206\u6790\u7b56\u7565\u5bf9\u5176TIME\u8fdb\u884c\u5206\u6790\uff0c\u5305\u62ec\uff08i\uff09\u514d\u75ab\u5b9a\u5411\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff0cn = 20\u540d\u60a3\u8005\uff09\u548c\uff08ii\uff09\u901a\u8fc7\u9488\u5bf9\u8d28\u8c31\u7ec6\u80de\u672f\u7684\u9776\u5411\u6297\u4f53\u9762\u677f\u5bf9\u86cb\u767d\u8868\u8fbe\u8fdb\u884c\u5206\u6790\uff08CyTOF\uff0cn = 12\u540d\u60a3\u8005\uff09\u3002\u6211\u4eec\u8fd8\u751f\u6210\u4e86\u5339\u914d\u7684T\u548cB\u7ec6\u80de\u7684V\uff08D\uff09J\u6d4b\u5e8f\u4ee5\u53caCD45+\u514d\u75ab\u7ec6\u80de\u7684\u5206\u6790\u3002<\/p>\n

\u7ed3\u679c\uff1a<\/strong>\u6211\u4eec\u53d1\u73b0\uff0c\u4e0e\u975eGSRCC\u76f8\u6bd4\uff0cGSRCC TIME\u4f3c\u4e4e\u662f\u9759\u6b62\u7684\uff0cCD4+\u548cCD8+ T\u7ec6\u80de\u90fd\u96be\u4ee5\u52a8\u5458\uff0c\u8fd9\u8fdb\u4e00\u6b65\u635f\u5bb3\u4e86B\u7ec6\u80de\u7684\u6b63\u5e38\u529f\u80fd\u3002CXCL13\u4e3b\u8981\u7531Tfh\u3001Th17\u548c\u75b2\u60eb\u7684CD8+ T\u7ec6\u80de\u4ea7\u751f\uff0c\u662f\u8fd9\u79cd\u8f6c\u5316\u7684\u4e2d\u5fc3\u534f\u8c03\u8005\u3002\u6211\u4eec\u5c55\u793a\u4e86CXCL13\u8868\u8fbe\u53ef\u4ee5\u9884\u6d4bGC\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u53cd\u5e94\uff0c\u8fd9\u53ef\u80fd\u4e0e\u5176\u5bf9\u4e09\u7ea7\u6dcb\u5df4\u7ed3\u6784\u7684\u5f71\u54cd\u6709\u5173\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/strong>\u6211\u4eec\u7684\u7814\u7a76\u4e3a\u665a\u671fGC\u60a3\u8005\u7684\u514d\u75ab\u7ec6\u80de\u7ec4\u6210\u548c\u7ec6\u80de\u72b6\u6001\u63d0\u4f9b\u4e86\u5168\u9762\u7684\u5206\u5b50\u56fe\u50cf\uff0c\u7a81\u51fa\u4e86GSRCC\u4e2d\u7684\u9002\u5e94\u6027\u514d\u75ab\u4e0d\u5e94\u6027\u4ee5\u53caCXCL13\u5728TIME\u4e2d\u7684\u5a92\u4ecb\u4f5c\u7528\u3002\u6211\u4eec\u7684\u5b9a\u5411\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u548c\u86cb\u767d\u8d28\u7ec4\u5206\u6790\u4ee3\u8868\u4e86\u4e00\u4e2a\u9488\u5bf9TIME\u7684\u8f6c\u5316\u7814\u7a76\u7684\u5f3a\u6709\u529b\u7684\u65b9\u6cd5\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CXCL13\uff1bT\u7ec6\u80de\u72b6\u6001\uff1b\u80c3\u764c\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230314<\/strong><\/p>\n<\/section>\n<\/section>\n

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Macrophages at the interface of the co-evolving cancer ecosystem<\/strong><\/p>\n

\u5de8\u566c\u7ec6\u80de\u5728\u764c\u75c7\u751f\u6001\u7cfb\u7edf\u8fdb\u5316\u4e2d\u7684\u4f5c\u7528<\/strong><\/span><\/p>\n

Cell. 2023 Mar 14;S0092-8674(23)00163-0.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.02.020.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36924769\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5de8\u566c\u7ec6\u80de\u662f\u591a\u529f\u80fd\u548c\u5f02\u8d28\u7684\u5148\u5929\u514d\u75ab\u7ec6\u80de\uff0c\u5728\u5e73\u8861\u514d\u75ab\u53cd\u5e94\u548c\u7ec4\u7ec7\u4fee\u590d\u4ee5\u7ef4\u6301\u7a33\u6001\u65b9\u9762\u627f\u62c5\u7740\u6838\u5fc3\u529f\u80fd\u3002\u4e00\u65e6\u6076\u6027\u751f\u957f\u5229\u7528\u4e86\u8fd9\u79cd\u53ef\u5851\u6027\uff0c\u5c31\u4f1a\u5728\u80bf\u7624\u5fae\u73af\u5883\u5185\u5f15\u8d77\u591a\u79cd\u7ec6\u80de\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u63a8\u52a8\u764c\u75c7\u751f\u6001\u7cfb\u7edf\u7684\u6f14\u5316\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u56de\u987e\u4e86\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u5171\u540c\u652f\u6491\u5e76\u957f\u671f\u5851\u9020\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u8868\u578b\u72b6\u6001\u7684\u591a\u5c42\u5f71\u54cd\u6765\u6e90\u3002\u6211\u4eec\u8ba8\u8bba\u4e86\u5728\u8fd9\u4e9b\u4fe1\u53f7\u7684\u4f5c\u7528\u4e0b\uff0cTAM\u5982\u4f55\u5728\u81ea\u7136\u9009\u62e9\u3001\u751f\u7269\u6269\u6563\u548c\u6cbb\u7597\u62b5\u6297\u7684\u80cc\u666f\u4e0b\u5f15\u5bfc\u80bf\u7624\u6f14\u5316\u3002\u672c\u7efc\u8ff0\u63d0\u51fa\u4e86\u4e00\u4e9b\u9700\u8981\u89e3\u51b3\u7684\u7814\u7a76\u524d\u6cbf\uff0c\u4ee5\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u5229\u7528TAM\u7684\u590d\u6742\u4f5c\u7528\u3002\u57fa\u4e8e\u76ee\u524d\u5e94\u7528\u7684TAM\u9776\u5411\u7b56\u7565\u6240\u83b7\u5f97\u7684\u77e5\u8bc6\u5e76\u4f7f\u7528\u4e0b\u4e00\u4ee3\u6280\u672f\uff0c\u6211\u4eec\u63d0\u51fa\u4e86\u6982\u5ff5\u6027\u8fdb\u5c55\u548c\u65b0\u7684\u6cbb\u7597\u9014\u5f84\uff0c\u4ee5\u91cd\u6784TAM\u5bf9\u5171\u540c\u8fdb\u5316\u7684\u764c\u75c7\u751f\u6001\u7cfb\u7edf\u7684\u591a\u65b9\u9762\u8c03\u63a7\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u764c\u75c7\u8fdb\u5316\uff1b\u514d\u75ab\u7cfb\u7edf\uff1b\u5de8\u566c\u7ec6\u80de\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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15<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Immunol. 20230310<\/strong><\/p>\n<\/section>\n<\/section>\n

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Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity<\/strong><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u8bf1\u5bfc\u80a0\u9053\u5fae\u751f\u7269\u79fb\u4f4d\u589e\u5f3a\u80a0\u5916\u6297\u80bf\u7624\u514d\u75ab\u529b<\/strong><\/span><\/p>\n

Sci Immunol. 2023 Mar 10;8(81):eabo2003.<\/em><\/p>\n

doi: <\/strong>10.1126\/sciimmunol.abo2003.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36867675\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80a0\u9053\u5fae\u751f\u7269\uff0c\u5c24\u5176\u662f\u80a0\u9053\u7ec6\u83cc\uff0c\u5bf9\u4e8e\u764c\u75c7\u6709\u6548\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\uff08ICT\uff09\u81f3\u5173\u91cd\u8981\u3002\u7136\u800c\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5982\u4f55\u589e\u5f3a\u80a0\u5916\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684\u673a\u5236\u8fd8\u5927\u591a\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u53d1\u73b0ICT\u8bf1\u5bfc\u7279\u5b9a\u5185\u6e90\u6027\u80a0\u9053\u7ec6\u83cc\u8fdb\u5165\u7ee7\u53d1\u6dcb\u5df4\u5668\u5b98\u548c\u76ae\u4e0b\u9ed1\u8272\u7d20\u7624\u80bf\u7624\u3002\u5728\u673a\u5236\u4e0a\uff0cICT\u8bf1\u5bfc\u6dcb\u5df4\u7ed3\u91cd\u5851\u548c\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u6fc0\u6d3b\uff0c\u4fc3\u8fdb\u9009\u62e9\u6027\u7684\u80a0\u9053\u5fae\u751f\u7269\u4e9a\u7fa4\u5411\u80a0\u5916\u7ec4\u7ec7\u8f6c\u4f4d\uff0c\u4ee5\u4fc3\u8fdb\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3\uff08TDLN\uff09\u548c\u539f\u53d1\u6027\u80bf\u7624\u7684\u6700\u4f73\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u3002\u6297\u751f\u7d20\u6cbb\u7597\u5bfc\u81f4\u80a0\u9053\u5fae\u751f\u7269\u8f6c\u4f4d\u5230\u80a0\u7cfb\u819c\u6dcb\u5df4\u7ed3\uff08MLNs\uff09\u548cTDLNs\u51cf\u5c11\uff0cDC\u548c\u6548\u5e94\u6027CD8+ T\u7ec6\u80de\u53cd\u5e94\u51cf\u5f31\uff0c\u5bf9ICT\u7684\u53cd\u5e94\u4e5f\u51cf\u5f31\u3002\u6211\u4eec\u7684\u53d1\u73b0\u9610\u660e\u4e86\u80a0\u9053\u5fae\u751f\u7269\u4fc3\u8fdb\u80a0\u5916\u6297\u764c\u514d\u75ab\u529b\u7684\u5173\u952e\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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16<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230222<\/strong><\/p>\n<\/section>\n<\/section>\n

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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer<\/strong><\/p>\n

\u8f7d\u8102\u86cb\u767dE\u5728\u524d\u5217\u817a\u764c\u4e2d\u8bf1\u5bfc\u75c5\u7406\u6027\u8870\u8001\u6837\u9ad3\u7cfb\u7ec6\u80de<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Feb 22;S1535-6108(23)00032-6.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.02.004.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36868226\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80bf\u7624\u7ec6\u80de\u4fc3\u8fdb\u514d\u75ab\u6291\u5236\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u62db\u52df\uff0c\u8fd9\u662f\u4e00\u79cd\u9a71\u52a8\u514d\u75ab\u6291\u5236\u3001\u80bf\u7624\u589e\u6b96\u548c\u6cbb\u7597\u62b5\u6297\u7684\u9ad3\u7cfb\u7ec6\u80de\u4e9a\u7fa4\u3002\u751f\u7406\u4e0a\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u88ab\u8ba4\u4e3a\u5bff\u547d\u77ed\u6682\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u62a5\u9053\u4e86\u4e00\u79cd\u4e2d\u6027\u7c92\u7ec6\u80de\u4e9a\u7fa4\uff0c\u5176\u4e0a\u8c03\u8868\u8fbe\u7ec6\u80de\u8870\u8001\u6807\u5fd7\u7269\u5e76\u5b58\u5728\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u3002\u8870\u8001\u6837\u4e2d\u6027\u7c92\u7ec6\u80de\u8868\u8fbe\u9ad3\u7cfb\u7ec6\u80de\u8868\u8fbe\u7684\u89e6\u53d1\u6027\u53d7\u4f532\uff08TREM2\uff09\uff0c\u6bd4\u7ecf\u5178\u7684\u514d\u75ab\u6291\u5236\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u66f4\u5177\u6709\u514d\u75ab\u6291\u5236\u548c\u4fc3\u8fdb\u80bf\u7624\u7684\u4f5c\u7528\u3002\u901a\u8fc7\u57fa\u56e0\u548c\u836f\u7269\u6d88\u9664\u8870\u8001\u6837\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u6211\u4eec\u53d1\u73b0\u53ef\u4ee5\u51cf\u7f13\u524d\u5217\u817a\u764c\u4e0d\u540c\u5c0f\u9f20\u6a21\u578b\u7684\u80bf\u7624\u53d1\u5c55\u3002\u5728\u673a\u5236\u4e0a\uff0c\u6211\u4eec\u53d1\u73b0\u524d\u5217\u817a\u80bf\u7624\u7ec6\u80de\u5206\u6ccc\u7684\u8f7d\u8102\u86cb\u767dE\uff08APOE\uff09\u7ed3\u5408\u4e2d\u6027\u7c92\u7ec6\u80de\u4e0a\u7684TREM2\uff0c\u4fc3\u8fdb\u5176\u8870\u8001\u3002APOE\u548cTREM2\u7684\u8868\u8fbe\u5728\u524d\u5217\u817a\u764c\u4e2d\u589e\u52a0\uff0c\u4e0e\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002\u8fd9\u4e9b\u7ed3\u679c\u63ed\u793a\u4e86\u4e00\u79cd\u80bf\u7624\u514d\u75ab\u9003\u907f\u7684\u66ff\u4ee3\u673a\u5236\uff0c\u5e76\u652f\u6301\u5f00\u53d1\u9488\u5bf9\u8870\u8001\u6837\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u514d\u75ab\u8870\u8001\u6e05\u9664\u5242\u4ee5\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u8f7d\u8102\u86cb\u767dE\uff1bHDAC\u6291\u5236\u5242\uff1b\u8870\u8001\uff1bTREM2\uff1b\u514d\u75ab\u8870\u8001\uff1b\u8870\u8001\u6807\u5fd7\u7269\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u524d\u5217\u817a\u764c\uff1b\u80bf\u7624\u5fae\u73af\u5883\uff1b\u80bf\u7624\u5206\u6ccc\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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17<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Commun. 20230303<\/strong><\/p>\n<\/section>\n<\/section>\n

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mTORC1 upregulates B7-H3\/CD276 to inhibit antitumor T cells and drive tumor immune evasion<\/strong><\/p>\n

mTORC1\u4e0a\u8c03B7-H3\/CD276\u4ee5\u6291\u5236\u6297\u80bf\u7624T\u7ec6\u80de\u5e76\u63a8\u52a8\u80bf\u7624\u514d\u75ab\u9003\u907f<\/strong><\/span><\/p>\n

Nat Commun. 2023 Mar 3;14(1):1214.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-023-36881-7.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36869048\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u53d1\u73b0\u8c03\u8282\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\u7684\u673a\u5236\u4ee5\u53ca\u9776\u5411\u5b83\u4eec\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u6cbb\u7597\u5f71\u54cd\u81f3\u5173\u91cd\u8981\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5c55\u793a\u4e86\u572811,060\u4e2aTCGA\u4eba\u7c7b\u80bf\u7624\u4e2d\uff0c\u9ad8\u8868\u8fbe\u7684\u514d\u75ab\u68c0\u67e5\u70b9B7-H3\uff08CD276\uff09\u548c\u9ad8mTORC1\u6d3b\u6027\u4e0e\u514d\u75ab\u6291\u5236\u8868\u578b\u548c\u66f4\u5dee\u7684\u4e34\u5e8a\u7ed3\u679c\u76f8\u5173\u3002\u6211\u4eec\u53d1\u73b0\uff0cmTORC1\u901a\u8fc7p70 S6\u6fc0\u9176\u5bf9\u8f6c\u5f55\u56e0\u5b50YY2\u8fdb\u884c\u76f4\u63a5\u78f7\u9178\u5316\uff0c\u4e0a\u8c03B7-H3\u7684\u8868\u8fbe\u3002\u6291\u5236B7-H3\u901a\u8fc7\u514d\u75ab\u4ecb\u5bfc\u673a\u5236\u6291\u5236mTORC1\u9ad8\u6d3b\u6027\u80bf\u7624\u751f\u957f\uff0c\u5305\u62ec\u589e\u52a0T\u7ec6\u80de\u6d3b\u6027\u548cIFN-\u03b3\u53cd\u5e94\u4ee5\u53ca\u589e\u52a0\u80bf\u7624\u7ec6\u80deMHC-II\u7684\u8868\u8fbe\u3002CITE-seq\u63ed\u793a\u5728B7-H3\u7f3a\u5931\u7684\u80bf\u7624\u4e2d\u663e\u8457\u589e\u52a0\u4e86\u7ec6\u80de\u6bd2\u6027\u7684CD38+CD39+CD4+ T\u7ec6\u80de\u3002\u5728\u6cdb\u4eba\u7c7b\u764c\u75c7\u4e2d\uff0c\u9ad8\u7ec6\u80de\u6bd2\u6027\u7684CD38+CD39+CD4+ T\u7ec6\u80de\u57fa\u56e0\u7279\u5f81\u4e0e\u66f4\u597d\u7684\u4e34\u5e8a\u9884\u540e\u76f8\u5173\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cmTORC1\u9ad8\u6d3b\u6027\u5b58\u5728\u4e8e\u8bb8\u591a\u4eba\u7c7b\u80bf\u7624\u4e2d\uff0c\u5305\u62ec\u7ed3\u8282\u6027\u786c\u5316\u75c7\uff08TSC\uff09\u548c\u6dcb\u5df4\u7ba1\u5e73\u6ed1\u808c\u7624\u75c5\uff08LAM\uff09\uff0c\u63a8\u52a8B7-H3\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6291\u5236\u7ec6\u80de\u6bd2\u6027CD4+ T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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18<\/strong><\/p>\n<\/section>\n<\/section>\n

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Trends Cancer. 20230302<\/strong><\/p>\n<\/section>\n<\/section>\n

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From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts<\/strong><\/p>\n

\u4ece\u95e8\u536b\u5230\u4f9b\u5e94\u5546\uff1a\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u5bf9\u514d\u75ab\u529f\u80fd\u7684\u8c03\u8282<\/strong><\/span><\/p>\n

Trends Cancer. 2023 Mar 2;S2405-8033(23)00020-1.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.trecan.2023.01.007.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36870916\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u662f\u5b9e\u4f53\u764c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u4e3b\u8981\u4fc3\u764c\u6210\u5206\u3002CAFs\u662f\u5f02\u8d28\u6027\u7684\uff0c\u7531\u591a\u4e2a\u4e9a\u7fa4\u7ec4\u6210\uff0c\u5177\u6709\u4e0d\u540c\u7684\u529f\u80fd\u3002\u8fd1\u5e74\u6765\uff0cCAFs\u5df2\u6210\u4e3a\u514d\u75ab\u9003\u907f\u7684\u4e3b\u8981\u4fc3\u8fdb\u56e0\u7d20\u3002CAFs\u504f\u5411\u4e8eT\u7ec6\u80de\u6392\u65a5\u548c\u8870\u7aed\uff0c\u4fc3\u8fdb\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u6027\u7ec6\u80de\u7684\u62db\u52df\uff0c\u5e76\u8bf1\u5bfc\u5de8\u566c\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u539f\u764c\u6027\u8868\u578b\u8f6c\u6362\u3002\u968f\u7740\u5bf9CAFs\u5f02\u8d28\u6027\u7684\u4e0d\u65ad\u8ba4\u8bc6\uff0c\u4eba\u4eec\u9010\u6e10\u7406\u89e3\u4e0d\u540c\u7684CAFs\u4e9a\u7fa4\u53ef\u80fd\u4f1a\u9a71\u52a8\u660e\u663e\u4e0d\u540c\u7684\u514d\u75ab\u8c03\u8282\u6548\u5e94\uff0c\u4e0e\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\u76f8\u4e92\u4f5c\u7528\uff0c\u751a\u81f3\u53ef\u80fd\u5bf9\u6076\u6027\u80bf\u7624\u4ea7\u751f\u5bf9\u7acb\u7684\u6548\u5e94\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u5bf9CAFs\u4e0e\u514d\u75ab\u76f8\u4e92\u4f5c\u7528\u5f53\u524d\u7684\u7406\u89e3\uff0c\u5b83\u4eec\u5bf9\u80bf\u7624\u8fdb\u5c55\u548c\u6cbb\u7597\u53cd\u5e94\u7684\u5f71\u54cd\u4ee5\u53ca\u5229\u7528CAFs\u4e0e\u514d\u75ab\u76f8\u4e92\u4f5c\u7528\u4f5c\u4e3a\u6f5c\u5728\u7684\u764c\u75c7\u6cbb\u7597\u9776\u70b9\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CAF\u5f02\u8d28\u6027\uff1bMHC-II\uff1bT\u7ec6\u80de\uff1bTAM\uff1bapCAF\uff1b\u764c\u75c7\uff1b\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1biCAF\uff1b\u514d\u75ab\u9003\u907f\uff1b\u514d\u75ab\u6cbb\u7597\uff1b\u5de8\u566c\u7ec6\u80de\uff1bmyCAF\uff1b\u57fa\u8d28\uff1b\u80bf\u7624\u5fae\u73af\u5883\uff1b\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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19<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Commun. 20230304<\/strong><\/p>\n<\/section>\n<\/section>\n

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CDK4\/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy<\/strong><\/p>\n

CDK4\/6\u6291\u5236\u89e6\u53d1ICAM1\u9a71\u52a8\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u5e76\u589e\u5f3aLKB1\u7a81\u53d8\u578b\u80ba\u764c\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u654f\u611f\u6027<\/strong><\/span><\/p>\n

Nat Commun. 2023 Mar 4;14(1):1247.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-023-36892-4.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36871040\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u809d\u6fc0\u9176B1\uff08LKB1\uff09\u7a81\u53d8\u5728\u80ba\u817a\u764c\u4e2d\u666e\u904d\u5b58\u5728\uff0c\u5e76\u4e14\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u6cbb\u7597\u7684\u8010\u836f\u6027\u9a71\u52a8\u56e0\u7d20\u3002\u5728\u8fd9\u91cc\uff0c\u5229\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e\uff0c\u6211\u4eec\u8bc1\u660e\u5728\u5177\u6709Lkb1\u6761\u4ef6\u6027\u6572\u9664\u7684Kras\u9a71\u52a8\u7684\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u6fc0\u6d3b\u7684T\u7ec6\u80de\u7684\u8f6c\u8fd0\u548c\u7c98\u9644\u8fc7\u7a0b\u5b58\u5728\u7f3a\u9677\u3002LKB1\u7a81\u53d8\u7684\u764c\u7ec6\u80de\u5bfc\u81f4\u7ec6\u80de\u95f4\u7c98\u9644\u5206\u5b50-1\uff08ICAM1\uff09\u663e\u8457\u6291\u5236\u3002\u5728Lkb1\u7f3a\u5931\u7684\u80bf\u7624\u4e2d\u5916\u6e90\u6027\u8868\u8fbeIcam1\u589e\u52a0\u4e86\u79fb\u690d\u7684SIINFEKL\u7279\u5f02\u6027CD8+ T\u7ec6\u80de\u7684\u5f52\u5de2\u548c\u6d3b\u5316\uff0c\u91cd\u65b0\u6fc0\u6d3b\u4e86\u80bf\u7624-\u6548\u5e94\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4f7f\u80bf\u7624\u91cd\u65b0\u5bf9ICB\u4ea7\u751f\u654f\u611f\u6027\u3002\u8fdb\u4e00\u6b65\u7684\u53d1\u73b0\u8bc1\u660e\uff0cCDK4\/6\u6291\u5236\u5242\u901a\u8fc7\u6291\u5236\u89c6\u7f51\u819c\u6bcd\u7ec6\u80de\u7624\u86cb\u767dRB\u7684\u78f7\u9178\u5316\uff0c\u5728LKB1\u7f3a\u5931\u7684\u764c\u7ec6\u80de\u4e2d\u4e0a\u8c03ICAM1\u8f6c\u5f55\u3002\u6700\u540e\uff0c\u4f7f\u7528CDK4\/6\u6291\u5236\u5242\u548cPD-1\u6297\u4f53\u7684\u5b9a\u5236\u7ec4\u5408\u7b56\u7565\u4fc3\u8fdb\u4e86ICAM1\u89e6\u53d1\u7684\u514d\u75ab\u5e94\u7b54\u5728\u591a\u4e2aLkb1\u7f3a\u5931\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u53d1\u751f\u3002\u6211\u4eec\u7684\u53d1\u73b0\u8868\u660e\uff0c\u80bf\u7624\u7ec6\u80de\u4e0a\u7684ICAM1\u534f\u8c03\u4e86\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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20<\/strong><\/p>\n<\/section>\n<\/section>\n

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Pharmacol Ther. 20230303<\/strong><\/p>\n<\/section>\n<\/section>\n

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Myeloid cells in the era of cancer immunotherapy: Top 3 unanswered questions<\/strong><\/p>\n

\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65f6\u4ee3\u4e0b\u7684\u9ad3\u7cfb\u7ec6\u80de\uff1a\u6392\u540d\u524d\u4e09\u7684\u672a\u89e3\u51b3\u95ee\u9898<\/strong><\/span><\/p>\n

Pharmacol Ther. 2023 Mar 3;108370.<\/em><\/p>\n

doi:<\/strong>10.1016\/j.pharmthera.2023.108370.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36871784\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u9ad3\u7cfb\u7ec6\u80de\u8d8a\u6765\u8d8a\u88ab\u8ba4\u4e3a\u662f\u534f\u8c03\u6216\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u4e2d\u5fc3\u89d2\u8272\u3002\u968f\u7740\u5355\u7ec6\u80de\u6280\u672f\u7b49\u9ad8\u5206\u8fa8\u7387\u5206\u6790\u65b9\u6cd5\u7684\u51fa\u73b0\uff0c\u6211\u4eec\u73b0\u5728\u6b63\u6df1\u5165\u8ba4\u8bc6\u5230\u5728\u80bf\u7624\u80cc\u666f\u4e0b\u9ad3\u7cfb\u7ec6\u80de\u7ec4\u5206\u7684\u5f02\u8d28\u6027\u548c\u590d\u6742\u6027\u3002\u7531\u4e8e\u5b83\u4eec\u9ad8\u5ea6\u53ef\u5851\u7684\u6027\u8d28\uff0c\u4ee5\u9ad3\u7cfb\u7ec6\u80de\u4e3a\u9776\u70b9\u7684\u5355\u4e00\u6cbb\u7597\u6216\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u8054\u5408\u6cbb\u7597\u5df2\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u548c\u764c\u75c7\u60a3\u8005\u4e2d\u5c55\u73b0\u51fa\u6709\u524d\u666f\u7684\u7ed3\u679c\u3002\u7136\u800c\uff0c\u9ad3\u7cfb\u7ec6\u80de\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u548c\u5206\u5b50\u7f51\u7edc\u7684\u590d\u6742\u6027\u5bfc\u81f4\u6211\u4eec\u5bf9\u4e0d\u540c\u9ad3\u7cfb\u7ec6\u80de\u4e9a\u7fa4\u5728\u80bf\u7624\u5f62\u6210\u4e2d\u7684\u4f5c\u7528\u4e86\u89e3\u4e0d\u8db3\uff0c\u8fd9\u4f7f\u5f97\u9ad3\u7cfb\u7ec6\u80de\u6210\u4e3a\u6cbb\u7597\u9776\u70b9\u9887\u5177\u6311\u6218\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u603b\u7ed3\u4e86\u4e0d\u540c\u7684\u9ad3\u7cfb\u7ec6\u80de\u4e9a\u7fa4\u53ca\u5176\u5728\u80bf\u7624\u8fdb\u5c55\u4e2d\u7684\u8d21\u732e\uff0c\u91cd\u70b9\u5173\u6ce8\u5355\u6838\u541e\u566c\u7ec6\u80de\u3002\u6211\u4eec\u8ba8\u8bba\u4e86\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65f6\u4ee3\uff0c\u56f0\u6270\u9ad3\u7cfb\u7ec6\u80de\u548c\u764c\u75c7\u9886\u57df\u7684\u4e09\u4e2a\u672a\u89e3\u51b3\u95ee\u9898\u3002\u901a\u8fc7\u8fd9\u4e9b\u95ee\u9898\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u9ad3\u7cfb\u7ec6\u80de\u7684\u8d77\u6e90\u548c\u7279\u6027\u5982\u4f55\u5f71\u54cd\u5176\u529f\u80fd\u548c\u75be\u75c5\u7ed3\u679c\u3002\u8fd8\u8ba8\u8bba\u4e86\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u7684\u4e0d\u540c\u9776\u5411\u9ad3\u7cfb\u7ec6\u80de\u7684\u6cbb\u7597\u7b56\u7565\u3002\u6700\u540e\uff0c\u901a\u8fc7\u5206\u6790\u7ed3\u679c\u8865\u507f\u6027\u7ec6\u80de\u548c\u5206\u5b50\u673a\u5236\u7684\u590d\u6742\u6027\uff0c\u6211\u4eec\u63a2\u8ba8\u4e86\u9ad3\u7cfb\u7ec6\u80de\u9776\u5411\u6cbb\u7597\u7684\u6301\u4e45\u6027\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u9002\u5e94\u6027\u514d\u75ab\uff1b\u6297\u80bf\u7624\u514d\u75ab\uff1b\u6811\u7a81\u72b6\u7ec6\u80de\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff1b\u514d\u75ab\u6291\u5236\uff1b\u5148\u5929\u6027\u514d\u75ab\uff1bMDSCs\uff1b\u5de8\u566c\u7ec6\u80de\uff1b\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u6027\u7ec6\u80de\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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21<\/strong><\/p>\n<\/section>\n<\/section>\n

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Signal Transduct Target Ther. 20230307<\/strong><\/p>\n<\/section>\n<\/section>\n

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Emerging phagocytosis checkpoints in cancer immunotherapy<\/strong><\/p>\n

\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u65b0\u5174\u7684\u541e\u566c\u4f5c\u7528\u68c0\u67e5\u70b9<\/strong><\/span><\/p>\n

Signal Transduct Target Ther. 2023 Mar 7;8(1):104.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41392-023-01365-z.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36882399\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e3b\u8981\u5305\u62ec\u514d\u75ab\u68c0\u67e5\u70b9\u9776\u5411\u6cbb\u7597\u548c\u5de5\u7a0b\u514d\u75ab\u7ec6\u80de\u7684\u79fb\u690d\uff0c\u901a\u8fc7\u5229\u7528\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u5bf9\u6297\u764c\u7ec6\u80de\uff0c\u5df2\u7ecf\u5f7b\u5e95\u6539\u53d8\u4e86\u80bf\u7624\u5b66\u9886\u57df\u3002\u764c\u7ec6\u80de\u901a\u8fc7\u8fc7\u8868\u8fbe\u68c0\u67e5\u70b9\u57fa\u56e0\u5e76\u52ab\u6301\u76f8\u5e94\u7684\u6291\u5236\u6027\u901a\u8def\u6765\u9003\u907f\u514d\u75ab\u76d1\u89c6\u3002\u541e\u566c\u4f5c\u7528\u68c0\u67e5\u70b9\uff0c\u5982CD47\u3001CD24\u3001MHC-I\u3001PD-L1\u3001STC-1\u548cGD2\uff0c\u5df2\u7ecf\u6210\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u91cd\u8981\u68c0\u67e5\u70b9\uff0c\u5b83\u4eec\u901a\u8fc7\u4f5c\u4e3a\u201c\u4e0d\u8981\u5403\u6211\u201d\u4fe1\u53f7\u6216\u4e0e\u201c\u5403\u6211\u201d\u4fe1\u53f7\u76f8\u4e92\u4f5c\u7528\u6765\u6291\u5236\u514d\u75ab\u53cd\u5e94\u3002\u541e\u566c\u4f5c\u7528\u68c0\u67e5\u70b9\u5c06\u5148\u5929\u514d\u75ab\u548c\u9002\u5e94\u6027\u514d\u75ab\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u8054\u7cfb\u8d77\u6765\u3002\u9057\u4f20\u6d88\u9664\u8fd9\u4e9b\u541e\u566c\u4f5c\u7528\u68c0\u67e5\u70b9\uff0c\u4ee5\u53ca\u963b\u65ad\u5b83\u4eec\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u53ef\u4ee5\u663e\u8457\u589e\u5f3a\u541e\u566c\u4f5c\u7528\u5e76\u51cf\u5c0f\u80bf\u7624\u5927\u5c0f\u3002\u5728\u6240\u6709\u541e\u566c\u4f5c\u7528\u68c0\u67e5\u70b9\u4e2d\uff0cCD47\u662f\u6700\u4e3a\u6df1\u5165\u7814\u7a76\u7684\uff0c\u5df2\u7ecf\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u4e2d\u5907\u53d7\u5173\u6ce8\u7684\u76ee\u6807\u3002CD47\u9776\u5411\u6297\u4f53\u548c\u6291\u5236\u5242\u5df2\u5728\u5404\u79cd\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u7814\u7a76\u3002\u7136\u800c\uff0c\u8d2b\u8840\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u4f3c\u4e4e\u662f\u4e00\u9879\u8270\u5de8\u7684\u6311\u6218\uff0c\u56e0\u4e3aCD47\u5728\u7ea2\u7ec6\u80de\u4e0a\u5e7f\u6cdb\u8868\u8fbe\u3002\u672c\u6587\u56de\u987e\u4e86\u5df2\u62a5\u9053\u7684\u541e\u566c\u4f5c\u7528\u68c0\u67e5\u70b9\uff0c\u8ba8\u8bba\u4e86\u5b83\u4eec\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u673a\u5236\u548c\u529f\u80fd\uff0c\u91cd\u70b9\u4ecb\u7ecd\u4e86\u9776\u5411\u8fd9\u4e9b\u68c0\u67e5\u70b9\u7684\u4e34\u5e8a\u8fdb\u5c55\uff0c\u5e76\u8ba8\u8bba\u4e86\u514b\u670d\u6311\u6218\u548c\u5b9e\u73b0\u7ed3\u5408\u5148\u5929\u514d\u75ab\u548c\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u7ec4\u5408\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u7684\u6f5c\u5728\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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22<\/strong><\/p>\n<\/section>\n<\/section>\n

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Blood. 20230308<\/strong><\/p>\n<\/section>\n<\/section>\n

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Plasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression<\/strong><\/p>\n

\u6d46\u7ec6\u80de\u6e90\u6027\u7ebf\u7c92\u4f53\u635f\u4f24\u76f8\u5173\u5206\u5b50\uff08mtDAMP\uff09\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80deSTING\u901a\u8def\u4fc3\u8fdb\u9aa8\u9ad3\u7624\u8fdb\u5c55<\/strong><\/span><\/p>\n

Blood. 2023 Mar 8;blood.2022018711.<\/em><\/p>\n

doi: <\/strong>10.1182\/blood.2022018711.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36888932\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7ebf\u7c92\u4f53\u635f\u4f24\u76f8\u5173\u5206\u5b50\uff08mtDAMPs\uff09\u5305\u62ec\u86cb\u767d\u8d28\u3001\u8102\u8d28\u3001\u4ee3\u8c22\u4ea7\u7269\u548cDNA\u7b49\uff0c\u5177\u6709\u4e0d\u540c\u7684\u73af\u5883\u7279\u5f02\u6027\u514d\u75ab\u8c03\u8282\u529f\u80fd\u3002\u65e0\u7ec6\u80de\u7ebf\u7c92\u4f53DNA\uff08mtDNA\uff09\u901a\u8fc7\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u88ab\u8bc6\u522b\uff0c\u5e76\u4e14\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u5f3a\u6548\u6fc0\u6d3b\u5242\u3002\u5728\u521b\u4f24\u548c\u764c\u75c7\u60a3\u8005\u7684\u5faa\u73af\u7cfb\u7edf\u4e2d\uff0c\u65e0\u7ec6\u80demtDNA\u5347\u9ad8\uff0c\u4f46\u5176\u529f\u80fd\u540e\u679c\u5c1a\u672a\u660e\u786e\u3002\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u4f9d\u8d56\u4e8e\u9aa8\u9ad3\uff08BM\uff09\u5fae\u73af\u5883\u5185\u7684\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u6765\u7ef4\u6301\u751f\u5b58\u548c\u53d1\u5c55\u3002\u5728\u8fd9\u91cc\uff0c\u5229\u7528\u4f53\u5185\u6a21\u578b\uff0c\u6211\u4eec\u63cf\u8ff0\u4e86MM\u7ec6\u80de\u6e90\u6027mtDAMP\u5728\u4fc3\u8fdb\u80bf\u7624BM\u5fae\u73af\u5883\u4e2d\u7684\u4f5c\u7528\uff0c\u4ee5\u53camtDAMP\u5728\u9aa8\u9ad3\u7624\u75be\u75c5\u8fdb\u5c55\u4e2d\u7684\u673a\u5236\u548c\u529f\u80fd\u540e\u679c\u3002\u9996\u5148\uff0c\u6211\u4eec\u786e\u5b9a\u4e86MM\u60a3\u8005\u5916\u5468\u8840\u6e05\u4e2dmtDNA\u6c34\u5e73\u7684\u5347\u9ad8\u4e0e\u5065\u5eb7\u5bf9\u7167\u7ec4\u76f8\u6bd4\u3002\u901a\u8fc7\u5c06MM1S\u7ec6\u80de\u79fb\u690d\u5230NSG\u5c0f\u9f20\u4e2d\uff0c\u6211\u4eec\u8fdb\u4e00\u6b65\u8bc1\u660e\u5347\u9ad8\u7684mtDNA\u6765\u6e90\u4e8eMM\u7ec6\u80de\u3002\u6211\u4eec\u8fdb\u4e00\u6b65\u8868\u660e\uff0cBM\u5de8\u566c\u7ec6\u80de\u901a\u8fc7STING\u901a\u8def\u611f\u77e5\u5e76\u54cd\u5e94mtDAMPs\uff0c\u6291\u5236\u8fd9\u4e00\u901a\u8def\u53ef\u4ee5\u51cf\u5c11KaLwRij-5TGM1\u5c0f\u9f20\u6a21\u578b\u4e2dMM\u80bf\u7624\u8d1f\u62c5\u3002\u6b64\u5916\uff0c\u6211\u4eec\u53d1\u73b0MM\u6e90\u6027mtDAMPs\u8bf1\u5bfcBM\u5de8\u566c\u7ec6\u80de\u4e0a\u8c03\u8d8b\u5316\u56e0\u5b50\u7279\u5f81\uff0c\u6291\u5236\u8be5\u7279\u5f81\u5bfc\u81f4MM\u7ec6\u80de\u4eceBM\u4e2d\u6d41\u51fa\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u8bc1\u660e\u4e86\u6076\u6027\u6d46\u7ec6\u80de\u91ca\u653emtDNA\uff0c\u4e00\u79cdmtDAMPs\u5f62\u5f0f\uff0c\u8fdb\u5165\u9aa8\u9ad3\u7624BM\u5fae\u73af\u5883\uff0c\u5e76\u901a\u8fc7STING\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\u3002\u6211\u4eec\u786e\u5b9a\u4e86\u8fd9\u4e9bmtDAMP\u6fc0\u6d3b\u7684\u5de8\u566c\u7ec6\u80de\u5728\u4fc3\u8fdb\u75be\u75c5\u8fdb\u5c55\u548c\u5728\u4fc3\u7624\u7684\u9aa8\u9ad3\u5fae\u73af\u5883\u4e2d\u4fdd\u7559MM\u7ec6\u80de\u65b9\u9762\u7684\u529f\u80fd\u89d2\u8272\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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23<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Clin Invest. 20230309<\/strong><\/p>\n<\/section>\n<\/section>\n

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Intercellular HIF1a reprogams mammary progenitors and myeloid immune evasion to drive high-risk breast lesions<\/strong><\/p>\n

\u7ec6\u80de\u95f4HIF1a\u91cd\u7f16\u7a0b\u4e73\u817a\u7956\u7ec6\u80de\u548c\u9ad3\u7cfb\u514d\u75ab\u9003\u9038\u63a8\u52a8\u9ad8\u5371\u4e73\u817a\u75c5\u53d8<\/strong><\/span><\/p>\n

J Clin Invest. 2023 Mar 9;e164348.<\/em><\/p>\n

doi: <\/strong>10.1172\/JCI164348.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36892943\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u4e73\u817a\u764c\u7684\u8d77\u6e90\uff0c\u65e0\u8bba\u662f\u521d\u53d1\u8fd8\u662f\u590d\u53d1\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5c55\u793a\u4e86\u66b4\u9732\u4e8e\u4f4e\u6c27\u6761\u4ef6\u4e0b\u7684\u6d78\u6da6\u6027\u4e73\u817a\u764c\u7ec6\u80de\u91ca\u653e\u5c0f\u578b\u7ec6\u80de\u5916\u56ca\u6ce1\uff08sEV\uff09\uff0c\u8fd9\u4e9bsEV\u7834\u574f\u4e86\u6b63\u5e38\u4e73\u817a\u4e0a\u76ae\u7684\u5206\u5316\uff0c\u6269\u5c55\u4e86\u5e72\u7ec6\u80de\u548c\u817a\u6ce1\u7956\u7ec6\u80de\uff0c\u5e76\u8bf1\u5bfc\u4e86\u975e\u5178\u578b\u5bfc\u7ba1\u589e\u751f\u548c\u4e0a\u76ae\u5185\u7624\u53d8\u3002\u8fd9\u4f34\u968f\u7740\u7cfb\u7edf\u6027\u514d\u75ab\u6291\u5236\uff0c\u5982\u589e\u52a0\u7684\u9ad3\u7cfb\u7ec6\u80de\u91ca\u653e\u7684\u201c\u8b66\u62a5\u7269\u8d28\u201dS100A9\uff0c\u4ee5\u53caEMT\u3001\u8840\u7ba1\u751f\u6210\u3001\u5c40\u90e8\u548c\u64ad\u6563\u6027\u817a\u7ba1\u4e0a\u76ae\u7ec6\u80de\u4fb5\u88ad\u7684\u81f4\u764c\u7279\u5f81\u7b49\u3002\u5728\u4e73\u817a\u817a\u4f53\u9a71\u52a8\u7684\u764c\u57fa\u56e0\uff08MMTV-PyMT\uff09\u5b58\u5728\u4e0b\uff0c\u4f4e\u6c27sEV\u52a0\u901f\u4e86\u53cc\u4fa7\u4e73\u817a\u764c\u7684\u53d1\u75c5\u548c\u8fdb\u5c55\u3002\u5728\u673a\u5236\u4e0a\uff0c\u901a\u8fc7\u5305\u88c5\u5728\u4f4e\u6c27sEV\u4e2d\u7684\u57fa\u56e0\u6216\u836f\u7269\u9776\u5411\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50-1\u03b1\uff08HIF1\u03b1\uff09\uff0c\u6216S100A9\u7684\u540c\u6e90\u6027\u7f3a\u5931\uff0c\u53ef\u4ee5\u6062\u590d\u4e73\u817a\u7684\u5206\u5316\uff0c\u6062\u590dT\u7ec6\u80de\u529f\u80fd\uff0c\u5e76\u9632\u6b62\u975e\u5178\u578b\u589e\u751f\u3002sEV\u8bf1\u5bfc\u7684\u4e73\u817a\u75c5\u53d8\u7684\u8f6c\u5f55\u7ec4\u7279\u5f81\u7c7b\u4f3c\u4e8e\u817a\u6ce1\u4e73\u817a\u764c\uff0c\u5e76\u4e14\u5728\u5faa\u73af\u7684sEV\u4e2d\u68c0\u6d4b\u5230\u7684HIF1\u03b1\u4e0e\u4e73\u817a\u764c\u7684\u590d\u53d1\u6709\u5173\u3002\u56e0\u6b64\uff0csEV-HIF1\u03b1\u4fe1\u53f7\u662f\u9a71\u52a8\u4e73\u817a\u8f6c\u5316\u7684\u91cd\u8981\u5c40\u90e8\u548c\u7cfb\u7edf\u6027\u673a\u5236\uff0c\u5177\u6709\u6f14\u53d8\u4e3a\u591a\u53d1\u6027\u4e73\u817a\u764c\u7684\u8f83\u9ad8\u98ce\u9669\u3002\u8fd9\u4e00\u9014\u5f84\u53ef\u80fd\u63d0\u4f9b\u817a\u6ce1\u4e73\u817a\u764c\u8fdb\u5c55\u7684\u6613\u4e8e\u83b7\u53d6\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u4e73\u817a\u764c\uff1b\u7ec6\u80de\u751f\u7269\u5b66\uff1b\u4f4e\u6c27\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u80bf\u7624\u5b66\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Host Microbe. 20230308<\/strong><\/p>\n<\/section>\n<\/section>\n

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Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance<\/strong><\/p>\n

\u7ec4\u7ec7\u9a7b\u7559\u7684Lachnospiraceae\u83cc\u79d1\u7ec6\u83cc\u901a\u8fc7\u4fc3\u8fdb\u80bf\u7624\u514d\u75ab\u76d1\u89c6\u6765\u62b5\u6297\u5927\u80a0\u764c\u7684\u53d1\u751f<\/strong><\/span><\/p>\n

Cell Host Microbe. 2023 Mar 8;31(3):418-432.e8.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.chom.2023.01.013.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36893736\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80a0\u9053\u83cc\u7fa4\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u8fdb\u5c55\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u7136\u800c\uff0c\u7ec4\u7ec7\u9a7b\u7559\u7684\u5171\u751f\u83cc\u5bf9CRC\u514d\u75ab\u76d1\u89c6\u7684\u5f71\u54cd\u4ecd\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5206\u6790\u4e86CRC\u60a3\u8005\u7ed3\u80a0\u7ec4\u7ec7\u4e2d\u7684\u7ec4\u7ec7\u5185\u7ec6\u83cc\u3002\u6211\u4eec\u53d1\u73b0\u5c5e\u4e8eLachnospiraceae\u83cc\u79d1\u7684\u5171\u751f\u83cc\uff0c\u5305\u62ecRuminococcus gnavus\uff08Rg\uff09\u3001Blautia producta\uff08Bp\uff09\u548cDorea formicigenerans\uff08Df\uff09\uff0c\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u5bcc\u96c6\uff0c\u800cFusobacterium nucleatum\uff08Fn\uff09\u548cPeptostreptococcus anaerobius\uff08Pa\uff09\u5219\u4e30\u5bcc\u4e8e\u80bf\u7624\u7ec4\u7ec7\u3002\u7ec4\u7ec7\u9a7b\u7559\u7684Rg\u548cBp\u51cf\u7f13\u4e86\u7ed3\u80a0\u80bf\u7624\u7684\u751f\u957f\uff0c\u5e76\u4fc3\u8fdb\u4e86\u514d\u75ab\u80fd\u529b\u6b63\u5e38\u7684\u5c0f\u9f20\u4e2dCD8+ T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002\u5728\u673a\u5236\u4e0a\uff0c\u7ec4\u7ec7\u5185\u7684Rg\u548cBp\u964d\u89e3\u4e86\u6291\u5236CD8+ T\u7ec6\u80de\u6d3b\u6027\u7684\u6eb6\u916a\u6c28\u9178\u7518\u6cb9\u78f7\u8102\uff0c\u5e76\u7ef4\u6301CD8+ T\u7ec6\u80de\u7684\u514d\u75ab\u76d1\u89c6\u529f\u80fd\u3002\u6eb6\u916a\u6c28\u9178\u7518\u6cb9\u78f7\u8102\u5355\u72ec\u53ef\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\uff0c\u800c\u6ce8\u5c04Rg\u548cBp\u5219\u6d88\u9664\u4e86\u8fd9\u79cd\u4fc3\u8fdb\u4f5c\u7528\u3002\u603b\u7684\u6765\u8bf4\uff0c\u7ec4\u7ec7\u5185\u7684Lachnospiraceae\u83cc\u79d1\u7ec6\u83cc\u6709\u52a9\u4e8e\u4fc3\u8fdbCD8+ T\u7ec6\u80de\u7684\u514d\u75ab\u76d1\u89c6\u529f\u80fd\uff0c\u5e76\u63a7\u5236\u7ed3\u76f4\u80a0\u764c\u7684\u8fdb\u5c55\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CD8+ T\u7ec6\u80de\uff1bLachnospiraceae\u83cc\u79d1\u7ec6\u83cc\uff1b\u7ed3\u76f4\u80a0\u764c\uff1b\u6eb6\u89e3\u916a\u6c28\u9178\u7518\u6cb9\u78f7\u8102\u7684\u964d\u89e3\uff1b\u514d\u75ab\u76d1\u89c6\uff1b\u7ec4\u7ec7\u9a7b\u7559\u7684\u5171\u751f\u83cc\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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25<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Genet. 20230309<\/strong><\/p>\n<\/section>\n<\/section>\n

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Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors<\/strong><\/p>\n

\u514d\u75ab\u9009\u62e9\u51b3\u5b9a\u80bf\u7624\u539f\u6297\u539f\u6027\u5e76\u5f71\u54cd\u5bf9\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u53cd\u5e94<\/strong><\/span><\/p>\n

Nat Genet. 2023 Mar 9.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41588-023-01313-1.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36894710\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5728\u764c\u75c7\u4e2d\uff0c\u8fdb\u5316\u529b\u91cf\u9009\u62e9\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u514b\u9686\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u4f7f\u7528\u514d\u75abdN \/ dS\uff08\u514d\u75ab\u80bd\u7ec4\u4e2d\u975e\u540c\u4e49\u7a81\u53d8\u4e0e\u540c\u4e49\u7a81\u53d8\u7684\u6bd4\u7387\uff09\u5206\u6790\u4e86> 10,000\u4e2a\u539f\u53d1\u6027\u80bf\u7624\u548c356\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\u7684\u8f6c\u79fb\u7624\uff0c\u4ee5\u6d4b\u91cf\u7fa4\u4f53\u548c\u4e2a\u4f53\u4e2d\u7684\u514d\u75ab\u9009\u62e9\u3002\u6211\u4eec\u5c06\u80bf\u7624\u5f52\u7c7b\u4e3a\u514d\u75ab\u7f16\u8f91\u7684\u80bf\u7624\uff0c\u5728\u8fd9\u7c7b\u80bf\u7624\u4e2d\u6297\u539f\u7a81\u53d8\u88ab\u8d1f\u9009\u62e9\u53bb\u9664\uff0c\u6297\u539f\u6027\u88ab\u6d88\u9664\uff0c\u4ece\u800c\u5bfc\u81f4\u514d\u75ab\u9003\u9038\u3002\u53ea\u6709\u5728\u514d\u75ab\u7f16\u8f91\u7684\u80bf\u7624\u4e2d\uff0c\u514d\u75ab\u63a0\u593a\u624d\u4e0eCD8 T\u7ec6\u80de\u7684\u6d78\u6da6\u76f8\u5173\u3002\u514d\u75ab\u9003\u9038\u7684\u8f6c\u79fb\u7624\u7ecf\u5386\u4e86\u6700\u597d\u7684\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\uff0c\u800c\u514d\u75ab\u7f16\u8f91\u7684\u60a3\u8005\u6ca1\u6709\u53d7\u76ca\uff0c\u8fd9\u8868\u660e\u6709\u9884\u5148\u5b58\u5728\u7684\u62b5\u6297\u673a\u5236\u3002\u540c\u6837\uff0c\u5728\u4e00\u4e2a\u7eb5\u5411\u961f\u5217\u4e2d\uff0c\u514d\u75ab\u80bd\u7ec4\u5b66\u7ed3\u679c\u663e\u793a\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u4ec5\u79fb\u9664\u4e86\u975e\u514d\u75ab\u7f16\u8f91\u60a3\u8005\u7684\u7684\u65b0\u6297\u539f\uff0c\u8fd9\u662f\u603b\u4f53\u751f\u5b58\u53cd\u5e94\u6700\u597d\u7684\u7fa4\u4f53\u3002\u6211\u4eec\u7684\u5de5\u4f5c\u4f7f\u7528dN \/ dS\u533a\u5206\u514d\u75ab\u7f16\u8f91\u548c\u514d\u75ab\u9003\u9038\u7684\u80bf\u7624\uff0c\u6d4b\u91cf\u53ef\u80fd\u7684\u6297\u539f\u6027\uff0c\u5e76\u6700\u7ec8\u5e2e\u52a9\u9884\u6d4b\u5bf9\u6cbb\u7597\u7684\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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26<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Rev Mol Cell Biol. 20230302<\/strong><\/p>\n<\/section>\n<\/section>\n

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Autophagy and autophagy-related pathways in cancer<\/strong><\/p>\n

\u81ea\u566c\u548c\u81ea\u566c\u76f8\u5173\u9014\u5f84\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528<\/strong><\/span><\/p>\n

Nat Rev Mol Cell Biol. 2023 Mar 2.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41580-023-00585-z.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36864290\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7ef4\u6301\u86cb\u767d\u8d28\u7a33\u6001\u548c\u7ec6\u80de\u5668\u7684\u5b8c\u6574\u6027\u548c\u529f\u80fd\u5bf9\u4e8e\u7ec6\u80de\u7a33\u6001\u548c\u7ec6\u80de\u5b58\u6d3b\u81f3\u5173\u91cd\u8981\u3002\u81ea\u566c\u662f\u4ecb\u5bfc\u5404\u79cd\u7ec6\u80de\u8d27\u7269\u8fd0\u8f93\u5230\u6eb6\u9176\u4f53\u8fdb\u884c\u964d\u89e3\u548c\u56de\u6536\u7684\u4e3b\u8981\u673a\u5236\u3002\u5927\u91cf\u7814\u7a76\u8bc1\u660e\uff0c\u81ea\u566c\u5728\u75be\u75c5\u9632\u5fa1\u65b9\u9762\u5177\u6709\u91cd\u8981\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5728\u764c\u75c7\u4e2d\uff0c\u81ea\u566c\u4f3c\u4e4e\u5728\u9632\u6b62\u65e9\u671f\u80bf\u7624\u53d1\u5c55\u548c\u7ef4\u6301\u53ca\u4ee3\u8c22\u9002\u5e94\u5df2\u5f62\u6210\u548c\u8f6c\u79fb\u7684\u80bf\u7624\u65b9\u9762\u8d77\u7740\u76f8\u4e92\u5bf9\u7acb\u7684\u4f5c\u7528\u3002\u8fd1\u671f\u7684\u7814\u7a76\u4e0d\u4ec5\u63a2\u7a76\u4e86\u81ea\u566c\u5728\u80bf\u7624\u7ec6\u80de\u5185\u56fa\u6709\u529f\u80fd\uff0c\u8fd8\u7814\u7a76\u4e86\u81ea\u566c\u5728\u80bf\u7624\u5fae\u73af\u5883\u548c\u76f8\u5173\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u8fd8\u63cf\u8ff0\u4e86\u5404\u79cd\u81ea\u566c\u76f8\u5173\u9014\u5f84\uff0c\u8fd9\u4e9b\u9014\u5f84\u4e0e\u7ecf\u5178\u81ea\u566c\u4e0d\u540c\uff0c\u90e8\u5206\u53ef\u5229\u7528\u81ea\u566c\u4fc3\u8fdb\u6076\u6027\u75be\u75c5\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u81ea\u566c\u53ca\u5176\u76f8\u5173\u8fc7\u7a0b\u5982\u4f55\u5f71\u54cd\u764c\u75c7\u7684\u53d1\u5c55\u548c\u8fdb\u5c55\uff0c\u8fd9\u6709\u52a9\u4e8e\u6307\u5bfc\u6291\u5236\u6216\u4fc3\u8fdb\u81ea\u566c\u7684\u57fa\u7840\u4e0a\u8bbe\u8ba1\u6297\u764c\u6cbb\u7597\u7684\u7b56\u7565\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u548c\u5256\u6790\u4e86\u81ea\u566c\u548c\u81ea\u566c\u76f8\u5173\u8fc7\u7a0b\u5728\u80bf\u7624\u53d1\u5c55\u3001\u7ef4\u6301\u548c\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u7684\u4e0d\u540c\u529f\u80fd\uff0c\u6982\u8ff0\u4e86\u5173\u4e8e\u8fd9\u4e9b\u8fc7\u7a0b\u5728\u80bf\u7624\u7ec6\u80de\u548c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4f5c\u7528\u7684\u6700\u65b0\u53d1\u73b0\uff0c\u5e76\u63cf\u8ff0\u4e86\u9488\u5bf9\u764c\u75c7\u4e2d\u81ea\u566c\u8fc7\u7a0b\u7684\u6cbb\u7597\u65b9\u9762\u7684\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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27<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Discov. 20230301<\/strong><\/p>\n<\/section>\n<\/section>\n

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Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy<\/strong><\/p>\n

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Cancer Discov. 2023 Mar 1;CD-21-0502.<\/em><\/p>\n

doi: <\/strong>10.1158\/2159-8290.CD-21-0502.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36856575\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u6cbb\u7597\u6027\u764c\u75c7\u75ab\u82d7\u8bd5\u56fe\u6fc0\u6d3b\u80bf\u7624\u53cd\u5e94\u6027T\u7ec6\u80de\uff0c\u4f7f\u5176\u80fd\u591f\u8bc6\u522b\u4e0e\u80bf\u7624\u76f8\u5173\u7684\u6297\u539f\uff08TAAs\uff09\u5e76\u6d88\u706d\u6076\u6027\u7ec6\u80de\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u63d0\u51fa\u4e86\u4e00\u79cd\u764c\u75c7\u75ab\u82d7\u65b9\u6cd5\uff0c\u5229\u7528\u7c92\u7ec6\u80de\u7cfb\u91cd\u7f16\u7a0b\u5c06\u764c\u7ec6\u80de\u76f4\u63a5\u8f6c\u5316\u4e3a\u80bf\u7624\u91cd\u7f16\u7a0b\u6297\u539f\u9012\u5448\u7ec6\u80de\uff08TR-APCs\uff09\u3002\u4f7f\u7528\u540c\u79cd\u5c0f\u9f20\u767d\u8840\u75c5\u6a21\u578b\uff0c\u6211\u4eec\u8bc1\u660eTR-APCs\u83b7\u5f97\u4e86\u7c92\u7ec6\u80de\u7cfb\u8868\u578b\u548c\u529f\u80fd\uff0c\u5904\u7406\u548c\u5448\u9012\u5185\u6e90\u6027TAAs\uff0c\u5e76\u5f3a\u70c8\u523a\u6fc0TAAs\u7279\u5f02\u6027\u7684CD4+\u548cCD8+ T\u7ec6\u80de\u3002\u5728\u4f53\u5185\u8bf1\u5bfcTR-APC\u53ef\u5f15\u8d77\u764c\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u514b\u9686\u6269\u589e\uff0c\u5efa\u7acb\u764c\u7279\u5f02\u6027\u514d\u75ab\u8bb0\u5fc6\uff0c\u5e76\u6700\u7ec8\u4fc3\u8fdb\u767d\u8840\u75c5\u7684\u6839\u9664\u3002\u6211\u4eec\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u548c\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u8089\u7624\u548c\u764c\u7624\uff0c\u90fd\u9002\u5408\u4e8e\u5c06\u7c92\u7ec6\u80de\u7cfb\u91cd\u7f16\u7a0b\u4e3aTR-APCs\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u6700\u540e\uff0c\u6211\u4eec\u901a\u8fc7\u4ece\u4e34\u5e8a\u539f\u59cb\u6837\u672c\u4e2d\u751f\u6210TR-APCs\u5e76\u523a\u6fc0\u81ea\u4f53\u60a3\u8005\u6765\u6e90\u7684T\u7ec6\u80de\uff0c\u8bc1\u660e\u4e86\u8fd9\u79cd\u65b9\u6cd5\u7684\u4e34\u5e8a\u9002\u7528\u6027\u3002\u56e0\u6b64\uff0cTR-APCs\u4ee3\u8868\u4e86\u4e00\u79cd\u5e7f\u6cdb\u9002\u7528\u4e8e\u4e34\u5e8a\u514d\u75ab\u80bf\u7624\u5b66\u7684\u764c\u75c7\u75ab\u82d7\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
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\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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