{"id":4993,"date":"2023-04-18T10:18:35","date_gmt":"2023-04-18T02:18:35","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/18\/monthly-updates-2022-12\/"},"modified":"2025-01-03T18:49:39","modified_gmt":"2025-01-03T10:49:39","slug":"monthly-updates-2022-12","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/04\/18\/monthly-updates-2022-12\/","title":{"rendered":"Monthly Updates 2022.12"},"content":{"rendered":"
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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gastroenterology. 20221126<\/strong><\/p>\n<\/section>\n<\/section>\n

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Integrated Multi-Omics Landscape of Liver Metastases<\/strong><\/p>\n

\u809d\u8f6c\u79fb\u7684\u6574\u5408\u591a\u7ec4\u5b66\u666f\u89c2<\/strong><\/span><\/p>\n

Gastroenterology. 2023 Mar;164(3):407-423.e17.<\/em><\/p>\n

doi: <\/strong>10.1053\/j.gastro.2022.11.029.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36574521\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80cc\u666f&\u76ee\u7684\uff1a<\/strong>\u5bf9\u5404\u79cd\u809d\u8f6c\u79fb\u7624\uff08LMs\uff09\u4e2d\u590d\u6742\u7684\u514d\u75ab\u5fae\u73af\u5883\uff08IM\uff09\u7f3a\u4e4f\u900f\u5f7b\u7684\u4e86\u89e3\u4f1a\u5bfc\u81f4\u6cbb\u7597\u4e0d\u5f53\u548c\u9884\u540e\u4e0d\u7406\u60f3\u3002\u6211\u4eec\u65e8\u5728\u8868\u5f81IM\u7684\u5404\u79cd\u4e9a\u578b\u5e76\u7814\u7a76\u809d\u8f6c\u79fb\u7684\u6f5c\u5728\u673a\u5236\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/strong>\u5e94\u7528\u8d28\u8c31\u7ec6\u80de\u672f\u8868\u5f81\u539f\u53d1\u6027\u809d\u764c\u548c\u809d\u8f6c\u79fb\u961f\u5217\u7684\u514d\u75ab\u666f\u89c2\u3002\u8f6c\u5f55\u7ec4\u548c\u5168\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\u7528\u4e8e\u63a2\u7d22\u4e0d\u540cIM\u4e9a\u578b\u5f62\u6210\u7684\u6f5c\u5728\u673a\u5236\u3002\u91c7\u7528\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\u3001\u591a\u91cd\u8367\u5149\u514d\u75ab\u7ec4\u5316\u3001\u7ec6\u80de\u57f9\u517b\u3001\u5c0f\u9f20\u6a21\u578b\u3001\u86cb\u767d\u8d28\u5370\u8ff9\u3001\u5b9a\u91cf\u805a\u5408\u9176\u94fe\u53cd\u5e94\u548c\u514d\u75ab\u7ec4\u5316\u7b49\u5b9e\u9a8c\u8fdb\u884c\u9a8c\u8bc1\u3002<\/p>\n

\u7ed3\u679c\uff1a<\/strong>\u5728100\u4f8bLMs\u548c50\u4f8b\u539f\u53d1\u6027\u809d\u764c\u4e2d\u53d1\u73b0\u4e865\u79cdIM\u4e9a\u578b\u3002\u5177\u6709\u7ec8\u672b\u8870\u7aed(IM1)\u6216\u7f55\u89c1T\u7ec6\u80de\u708e\u75c7(IM2\u548cIM3)\u514d\u75ab\u7279\u5f81\u7684\u60a3\u8005\u9884\u540e\u8f83\u5dee\u3002\u6076\u6027\u4e9a\u578b\u7684\u5f62\u6210\u4e0e\u80bf\u7624\u5185\u90e8\u5f02\u8d28\u6027\u589e\u52a0\u3001\u4f53\u7ec6\u80deTP53\u3001KRAS\u3001APC\u3001PIK3CA\u7a81\u53d8\u4e30\u5bcc\u4ee5\u53ca\u7f3a\u6c27\u4fe1\u53f7\u8fc7\u5ea6\u6fc0\u6d3b\u6709\u5173\u3002SLC2A1\u901a\u8fc7\u589e\u52a0\u809d\u8f6c\u79fb\u75c5\u7076\u4e2dSpp1+\u5de8\u566c\u7ec6\u80de\u7684\u6bd4\u4f8b\u53ca\u5176\u5bf9T\u7ec6\u80de\u7684\u6291\u5236\u4f5c\u7528\u4fc3\u8fdb\u514d\u75ab\u6291\u5236\u3002\u6b64\u5916\uff0cSLC2A1\u5728\u539f\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u901a\u8fc7\u8bf1\u5bfcTregs\u548cLAG3+CD4+ T\u7ec6\u80de\u7b49\u8c03\u8282\u6027T\u7ec6\u80de\u4fc3\u8fdb\u514d\u75ab\u9003\u9038\u548c\u809d\u8f6c\u79fb\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/strong>\u8be5\u7814\u7a76\u63d0\u4f9b\u4e86\u809d\u8f6c\u79fb\u7684\u6574\u5408\u591a\u7ec4\u5b66\u666f\u89c2\uff0c\u63ed\u793a\u4e86\u6076\u6027IM\u4e9a\u578b\u5f62\u6210\u7684\u6f5c\u5728\u673a\u5236\uff0c\u5e76\u786e\u8ba4\u4e86SLC2A1\u5728\u539f\u53d1\u80bf\u7624\u548c\u809d\u8f6c\u79fb\u75c5\u7076\u4e2d\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u91cd\u6784\u7684\u4f5c\u7528\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u809d\u8f6c\u79fb\uff1b\u591a\u7ec4\u5b66\uff1bSLC2A1; \u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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02<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Immunol. 20221221<\/strong><\/p>\n<\/section>\n<\/section>\n

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Rebalancing TGF\u03b21\/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy<\/strong><\/p>\n

\u5728\u8017\u7aed\u6027T\u7ec6\u80de\u4e2d\u91cd\u65b0\u5e73\u8861TGF\u03b21 \/ BMP\u4fe1\u53f7\u53ef\u89e3\u9501\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u53cd\u5e94<\/strong><\/span><\/p>\n

Nat Immunol. 2023 Feb;24(2):280-294.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41590-022-01384-y. <\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36543960\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

T\u7ec6\u80de\u529f\u80fd\u969c\u788d\u53ef\u963b\u788d\u514d\u75ab\u7cfb\u7edf\u5bf9\u6162\u6027\u611f\u67d3\u548c\u764c\u75c7\u7684\u6e05\u9664\u3002\u6b64\u5916\uff0c\u529f\u80fd\u5931\u8c03\u7684CD8+ T\u7ec6\u80de\u4e2d\u7684\u8868\u89c2\u9057\u4f20\u7f16\u7a0b\u9650\u5236\u4e86\u5b83\u4eec\u5bf9\u514d\u75ab\u7597\u6cd5\u7684\u53cd\u5e94\uff0c\u5305\u62ec\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u7597\u6cd5\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u54ea\u4e9b\u4e0a\u6e38\u4fe1\u53f7\u9a71\u52a8\u4e86\u529f\u80fd\u5931\u8c03\u7684\u8868\u89c2\u9057\u4f20\u7a0b\u5e8f\u7684\u5f62\u6210\uff0c\u4ee5\u53ca\u9776\u5411\u6cbb\u7597\u8fd9\u4e9b\u4fe1\u53f7\u662f\u5426\u53ef\u4ee5\u5c06\u7ec8\u672b\u529f\u80fd\u5931\u8c03\u7684T\u7ec6\u80de\u91cd\u5851\u4e3a\u53ef\u5bf9ICB\u53cd\u5e94\u7684\u72b6\u6001\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5efa\u7acb\u4e86\u4e00\u79cd\u7a33\u5b9a\u7684\u4eba\u7c7bT\u7ec6\u80de\u529f\u80fd\u969c\u788d\u7684\u4f53\u5916\u6a21\u578b\u7cfb\u7edf\uff0c\u5e76\u8868\u660e\u6548\u5e94\u540eCD8+ T\u7ec6\u80de\u4e2d\u7684\u6162\u6027TGF\u03b21\u4fe1\u53f7\u901a\u8fc7\u7a33\u5b9a\u7684\u8868\u89c2\u9057\u4f20\u53d8\u5316\u52a0\u901f\u4e86T\u7ec6\u80de\u7684\u7ec8\u672b\u529f\u80fd\u969c\u788d\u3002\u76f8\u53cd\uff0c\u5728\u963b\u65adTGF\u03b21\u7684\u540c\u65f6\u589e\u5f3a\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d\uff08BMP\uff09\u4fe1\u53f7\u4f20\u5bfc\uff0c\u5728\u6162\u6027\u523a\u6fc0\u7684\u4ebaCD8+ T\u7ec6\u80de\u4e2d\u4fdd\u7559\u4e86\u6548\u5e94\u548c\u8bb0\u5fc6\u76f8\u5173\u7a0b\u5e8f\uff0c\u5e76\u4e14\u53ef\u8bf1\u5bfcT\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u663e\u8457\u53cd\u5e94\uff0c\u5e76\u53ef\u5728\u6162\u6027\u75c5\u6bd2\u611f\u67d3\u671f\u95f4\u534f\u540cICB\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u91cd\u65b0\u5e73\u8861TGF\u03b21 \/ BMP\u4fe1\u53f7\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u65b9\u6cd5\u6765\u62ef\u6551\u529f\u80fd\u5931\u8c03\u7684CD8+ T\u7ec6\u80de\u5e76\u589e\u5f3aT\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Death Differ. 20221220<\/strong><\/p>\n<\/section>\n<\/section>\n

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Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer<\/strong><\/p>\n

\u9776\u5411\u6cdb\u7d20\u7279\u5f02\u6027\u86cb\u767d\u91768\u53ef\u5728\u80f0\u817a\u764c\u4e2d\u589e\u6548\u6297PD-L1\u514d\u75ab\u7597\u6cd5<\/strong><\/span><\/p>\n

Cell Death Differ. 2023 Feb;30(2):560-575.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41418-022-01102-z.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36539510\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

PD-1\u53ca\u5176\u914d\u4f53PD-L1\u53ef\u5e2e\u52a9\u80bf\u7624\u7ec6\u80de\u9003\u907f\u514d\u75ab\u76d1\u89c6\uff0c\u88ab\u89c6\u4e3a\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u91cd\u8981\u9776\u70b9\u3002PD-L1\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\u5728\u514d\u75ab\u6291\u5236\u65b9\u9762\u5177\u6709\u6f5c\u5728\u4ef7\u503c\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u786e\u5b9a\u4e86\u6cdb\u7d20\u7279\u5f02\u6027\u86cb\u767d\u91768\uff08USP8\uff09\u53ef\u53bb\u6cdb\u7d20\u5316PD-L1\u3002\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u76f8\u6bd4\uff0c\u80f0\u817a\u764c\u7ec4\u7ec7\u7684USP8\u6c34\u5e73\u663e\u7740\u589e\u52a0\u3002\u4e34\u5e8a\u4e0a\uff0cUSP8\u7684\u8868\u8fbe\u4e0e\u4f17\u591a\u60a3\u8005\u6765\u6e90\u7684\u80f0\u817a\u764c\u961f\u5217\u4e2d\u7684\u80bf\u7624\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7684\u5206\u671f\u663e\u8457\u76f8\u5173\u3002\u540c\u65f6\uff0cUSP8\u7f3a\u4e4f\u53ef\u4ee5\u4ee5\u514d\u75ab\u4f9d\u8d56\u7684\u65b9\u5f0f\u51cf\u5c11\u80bf\u7624\u4fb5\u88ad\u548c\u8fc1\u79fb\u4ee5\u53ca\u80bf\u7624\u5927\u5c0f\uff0c\u5e76\u63d0\u9ad8\u6297\u80bf\u7624\u514d\u75ab\u539f\u6027\u3002USP8\u6291\u5236\u5242\u9884\u5904\u7406\u5bfc\u81f4\u80bf\u7624\u53d1\u751f\u51cf\u5c11\uff0c\u5e76\u4e14Usp8\u6572\u4f4e\u540e\u7684\u80bf\u7624\u63a5\u79cd\u7684\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u7684\u5c0f\u9f20\u8868\u73b0\u51fa\u66f4\u957f\u7684\u751f\u5b58\u671f\u3002\u6b64\u5916\uff0cUSP8\u4e0ePD-L1\u5177\u6709\u6b63\u5411\u76f8\u4e92\u4f5c\u7528\uff0c\u5728\u80f0\u817a\u764c\u4e2d\u53ef\u901a\u8fc7\u6291\u5236\u6cdb\u7d20\u5316\u8c03\u8282\u7684\u86cb\u767d\u9176\u4f53\u964d\u89e3\u9014\u5f84\u4e0a\u8c03PD-L1\u7684\u8868\u8fbe\u3002USP8\u6291\u5236\u5242\u548c\u6297PD-L1\u8054\u5408\u6cbb\u7597\u53ef\u901a\u8fc7\u6fc0\u6d3b\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u6709\u6548\u6291\u5236\u80f0\u817a\u80bf\u7624\u751f\u957f\uff0c\u8fd9\u79cd\u6297\u80bf\u7624\u514d\u75ab\u4e3b\u8981\u4f9d\u8d56\u4e8ePD-L1\u901a\u8def\u548cCD8+T\u7ec6\u80de\u3002\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u5f3a\u8c03\u4e86\u9776\u5411USP8\u7684\u91cd\u8981\u610f\u4e49\uff0cUSP8\u53ef\u4ee5\u4f7f\u80f0\u817a\u764c\u5bf9\u6297PD-L1\u514d\u75ab\u7597\u6cd5\u66f4\u654f\u611f\uff0c\u8fd9\u79cd\u5c1d\u8bd5\u53ef\u80fd\u6210\u4e3a\u672a\u6765\u6cbb\u7597\u80f0\u817a\u80bf\u7624\u7684\u65b0\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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04<\/strong><\/p>\n<\/section>\n<\/section>\n

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Immunity. 20221219<\/strong><\/p>\n<\/section>\n<\/section>\n

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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer<\/strong><\/p>\n

\u5916\u6838\u82f7\u9178\u9176CD39\u9274\u5b9a\u80bf\u7624\u53cd\u5e94\u6027CD8+ T\u7ec6\u80de\uff0c\u4ece\u800c\u9884\u6d4b\u4eba\u7c7b\u80ba\u764c\u4e2d\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u529f\u6548<\/strong><\/span><\/p>\n

Immunity. 2023 Jan 10;56(1):93-106.e6. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.immuni.2022.12.001.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36574773\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u4e3a\u4e86\u63a8\u8fdb\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u66f4\u7cbe\u786e\u5730\u9274\u5b9a\u80bf\u7624\u53cd\u5e94\u6027T\u7ec6\u80de\u975e\u5e38\u5fc5\u8981\u3002CD39\u8868\u8fbe\u6709\u5e0c\u671b\u6210\u4e3a\u80bf\u7624\u53cd\u5e94\u6027CD8+ T\u7ec6\u80de\u7684\u9274\u5b9a\u6807\u5fd7\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5168\u9762\u5206\u6790\u4e86CD39\u5728\u4eba\u7c7b\u80ba\u764c\u4e2d\u7684\u8868\u8fbe\u3002CD39\u8868\u8fbe\u5bcc\u96c6\u4e8e\u5177\u6709\u8017\u7aed\u6027\u3001\u80bf\u7624\u53cd\u5e94\u6027\u548c\u514b\u9686\u6269\u589e\u7279\u5f81\u7684CD8+ T\u7ec6\u80de\u3002\u5bf9440\u4efd\u80ba\u764c\u751f\u7269\u6807\u672c\u8fdb\u884c\u4e86\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u7ed3\u679c\u663e\u793aCD39+ CD8+ T\u7ec6\u80de\u4e0e\u4e00\u4e9b\u80bf\u7624\u7279\u5f81\uff08\u5982PD-L1\u3001\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u548c\u9a71\u52a8\u7a81\u53d8\uff09\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u8f83\u5f31\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u53ef\u589e\u52a0\u80bf\u7624\u5185\u7684CD39+ CD8+ T\u7ec6\u80de\u3002\u800cCD39+ CD8+ T\u7ec6\u80de\u7684\u57fa\u7ebf\u9891\u7387\u8d8a\u9ad8\uff0cICB\u6cbb\u7597\u7684\u4e34\u5e8a\u7ed3\u5c40\u5c31\u8d8a\u597d\u3002\u6b64\u5916\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d1\u73b0\uff0cCD39+ CD8+ T\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u7279\u5f81\u53ef\u9884\u6d4bICB\u6cbb\u7597\u7684\u6f5c\u5728\u6548\u679c\u3002\u8fd9\u4e9b\u53d1\u73b0\u8bc1\u660e\u4e86CD39\u53ef\u6210\u4e3a\u4eba\u7c7b\u80ba\u764c\u4e2d\u80bf\u7624\u53cd\u5e94\u6027CD8+ T\u7ec6\u80de\u6807\u5fd7\u7269\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CD8+ T \u7ec6\u80de\uff1bT\u7ec6\u80de\u53d7\u4f53\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff1b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff1b\u80bf\u7624\u7a81\u53d8\u8d1f\u8377<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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05<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Adv. 20221216<\/strong><\/p>\n<\/section>\n<\/section>\n

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EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer<\/strong><\/p>\n

EGFR\u662f\u708e\u6027\u4e73\u817a\u764c\u4e2d\u514d\u75ab\u6291\u5236\u6027\u548c\u514d\u75ab\u6fc0\u6d3b\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e4b\u95f4\u7684\u4e3b\u5f00\u5173<\/strong><\/span><\/p>\n

Sci Adv. 2022 Dec 16;8(50):eabn7983. <\/em><\/p>\n

doi: <\/strong>10.1126\/sciadv.abn7983.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36525493\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u708e\u6027\u4e73\u817a\u764c\uff08IBC\uff09\u662f\u6700\u5177\u4fb5\u88ad\u6027\u7684\u4e73\u817a\u764c\u4e9a\u578b\uff0c\u7531\u514d\u75ab\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u9a71\u52a8\u3002\u76ee\u524d\u5bf9IBC\u7684\u6cbb\u7597\u6548\u679c\u6709\u9650\u3002\u5728\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT01036087\uff09\u4e2d\uff0c\u6297EGFR\u6297\u4f53\u8054\u5408\u65b0\u8f85\u52a9\u5316\u7597\uff08\u5b9e\u65bd\u5c40\u90e8\u6cbb\u7597\u65b9\u6cd5\u524d\u6240\u505a\u7684\u5168\u8eab\u5316\u7597\uff09\u5728\u5177\u6709\u4e09\u9634\u6027\u53d7\u4f53\u72b6\u6001\u7684IBC\u60a3\u8005\u4e2d\u4ea7\u751f\u4e86\u6709\u53f2\u4ee5\u6765\u6700\u9ad8\u7684\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\u3002\u6211\u4eec\u7814\u7a76\u5e76\u786e\u5b9a\u4e86\u8fd9\u79cd\u826f\u597d\u4e34\u5e8a\u7ed3\u679c\u80cc\u540e\u7684\u5206\u5b50\u548c\u514d\u75ab\u673a\u5236\u3002\u4f7f\u7528\u65b0\u578b\u4eba\u6e90\u5316IBC\u5c0f\u9f20\u6a21\u578b\uff0c\u6211\u4eec\u53d1\u73b0EGFR\u9776\u5411\u6cbb\u7597\u901a\u8fc7\u589e\u52a0\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u548c\u51cf\u5c11\u514d\u75ab\u6291\u5236\u8c03\u8282\u6027T\u7ec6\u80de\u4ee5\u53caM2\u578b\u5de8\u566c\u7ec6\u80de\u6765\u91cd\u5851IBC\u7684TME\u3002\u8fd9\u4e9b\u53d8\u5316\u662f\u7531\u4e8e\u8f6c\u5f55\u56e0\u5b50EGR1\u8c03\u8282\u7684\u514d\u75ab\u6291\u5236\u8d8b\u5316\u56e0\u5b50\u7684\u8868\u8fbe\u51cf\u5c11\u5bfc\u81f4\u7684\u3002\u6211\u4eec\u8fd8\u8bc1\u660e\u4e86\uff0c\u901a\u8fc7\u6297EGFR\u6297\u4f53\u8bf1\u5bfc\u514d\u75ab\u6fc0\u6d3b\u578b\u7684\u7684IBC TME\uff0c\u63d0\u9ad8\u4e86\u6297PD-L1\u6297\u4f53\u7597\u6cd5\u7684\u6297\u80bf\u7624\u529f\u6548\u3002\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u4e3aEGFR\u9776\u5411\u6cbb\u7597\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u764c\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20221214<\/strong><\/p>\n<\/section>\n<\/section>\n

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Ovarian cancer mutational processes drive site-specific immune evasion<\/strong><\/p>\n

\u5375\u5de2\u764c\u7a81\u53d8\u8fc7\u7a0b\u9a71\u52a8\u4f4d\u70b9\u7279\u5f02\u6027\u514d\u75ab\u9003\u9038<\/strong><\/span><\/p>\n

Nature. 2022 Dec 14.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-022-05496-1.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36517593\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u9ad8\u7ea7\u522b\u6d46\u6db2\u6027\u5375\u5de2\u764c\uff08HGSOC\uff09\u662f\u4e00\u79cd\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u7684\u5178\u578b\u764c\u75c7\uff0c\u53ef\u8868\u73b0\u4e3a\u4e0d\u540c\u7684\u7a81\u53d8\u9a71\u4f7f\u7684\u80bf\u7624\u5f02\u578b\u6027\u548c\u8179\u819c\u5185\u6269\u6563\u3002\u514d\u75ab\u7597\u6cd5\u5728\u9ad8\u7ea7\u522b\u6d46\u6db2\u6027\u5375\u5de2\u764c\u4e2d\u7684\u7597\u6548\u6709\u9650\uff0c\u7a81\u663e\u4e86\u8bc4\u4f30\u7a81\u53d8\u8fc7\u7a0b\u548c\u80bf\u7624\u75c5\u7076\u7684\u89e3\u5256\u90e8\u4f4d\u5982\u4f55\u51b3\u5b9a\u80bf\u7624\u5fae\u73af\u5883\u514d\u75ab\u72b6\u6001\u7684\u8feb\u5207\u9700\u8981\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5bf9\u6765\u81ea42\u540d\u672a\u7ecf\u6cbb\u7597\u7684HGSOC\u60a3\u8005\u7684160\u4e2a\u80bf\u7624\u90e8\u4f4d\u8fdb\u884c\u4e86\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\uff0c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u6570\u5b57\u7ec4\u7ec7\u75c5\u7406\u5b66\u548c\u591a\u91cd\u514d\u75ab\u8367\u5149\u7684\u7efc\u5408\u5206\u6790\u3002\u7f3a\u4e4f\u540c\u6e90\u91cd\u7ec4\u4fee\u590d\uff08HRD\uff09\u7684\u57fa\u56e0\u7a81\u53d8\uff08\u7c7b\u4f3cBRCA1\uff09\u548cHRD-Del\uff08\u7c7b\u4f3cBRCA2\uff09\u7684\u80bf\u7624\u5177\u6709\u708e\u75c7\u4fe1\u53f7\u548c\u6301\u7eed\u7684\u514d\u75ab\u7f16\u8f91\uff0c\u8868\u73b0\u4e3aHLA\u591a\u6837\u6027\u7684\u4e27\u5931\u548c\u9ad8\u5ea6\u5206\u5316\u7684\u529f\u80fd\u5931\u8c03CD8+ T\u7ec6\u80de\u7684\u80bf\u7624\u6d78\u6da6\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u643a\u5e26\u6298\u8fd4\u5012\u4f4d\u7684\u80bf\u7624\u8868\u73b0\u51fa\u589e\u9ad8\u7684\u514d\u75ab\u6291\u5236\u6027TGF\u03b2\u4fe1\u53f7\u548c\u514d\u75ab\u6392\u65a5\uff0c\u5b83\u4eec\u7684\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u4e3b\u8981\u662f\u5e7c\u7a1a\/\u5e72\u7ec6\u80de\u6837\u7684T\u7ec6\u80de\u548c\u8bb0\u5fc6T\u7ec6\u80de\u3002\u80bf\u7624\u7684\u7279\u5b9a\u89e3\u5256\u90e8\u4f4d\u4e0e\u8868\u578b\u72b6\u6001\u6709\u5173\uff0c\u9644\u4ef6\u80bf\u7624\u548c\u8fdc\u7aef\u8179\u819c\u75c5\u7076\u4e4b\u95f4\u7684\u7ec4\u6210\u3001\u62d3\u6251\u548c\u529f\u80fd\u90fd\u6709\u660e\u663e\u5dee\u5f02\u3002\u6211\u4eec\u7684\u53d1\u73b0\u8868\u660e\u89e3\u5256\u90e8\u4f4d\u548c\u7a81\u53d8\u8fc7\u7a0b\u662fHGSOC\u8fdb\u5316\u51fa\u8868\u578b\u5dee\u5f02\u548c\u514d\u75ab\u62b5\u6297\u673a\u5236\u7684\u51b3\u5b9a\u56e0\u7d20\u3002\u6211\u4eec\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u79cd\u591a\u7ec4\u5b66\u7ec6\u80de\u8868\u578b\u7684\u6570\u636e\u57fa\u7840\uff0c\u6709\u671b\u4ece\u4e2d\u5f00\u53d1\u548c\u8be0\u91ca\u672a\u6765\u7684\u4e2a\u6027\u5316\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u548c\u65e9\u671f\u68c0\u6d4b\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/strong><\/p>\n<\/section>\n<\/section>\n

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Pharmacol Ther. 20221213<\/strong><\/p>\n<\/section>\n<\/section>\n

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Tumor-derived extracellular vesicles in the colorectal cancer immune environment and immunotherapy<\/strong><\/p>\n

\u7ed3\u76f4\u80a0\u764c\u514d\u75ab\u73af\u5883\u4e0e\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u80bf\u7624\u6e90\u6027\u5916\u6ccc\u4f53<\/strong><\/span><\/p>\n

Pharmacol Ther. 2022 Dec 13;108332.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.pharmthera.2022.108332.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36526013\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5c3d\u7ba1\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u7b5b\u67e5\u3001\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\uff0c\u4f46\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09\u5728\u9ad8\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u75be\u75c5\u4e4b\u5916\u7684\u6548\u7528\u4ecd\u7136\u6709\u9650\u3002\u9274\u4e8e\u6076\u6027\u80bf\u7624\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u53cd\u5e94\u8f83\u4e3a\u6301\u4e45\uff0c\u63d0\u9ad8CRC\u5bf9ICI\u6cbb\u7597\u7684\u6709\u6548\u7387\u662f\u4e34\u5e8a\u7814\u7a76\u7684\u4e00\u4e2a\u6d3b\u8dc3\u9886\u57df\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u884d\u751f\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff08TEV\uff09\u662f\u80bf\u7624\u4fe1\u53f7\u4f20\u5bfc\u7684\u5173\u952e\u8c03\u8282\u5242\uff0c\u4e5f\u662f\u80bf\u7624\u5fae\u73af\u5883\u7684\u51b3\u5b9a\u56e0\u7d20\u3002\u4e34\u5e8a\u524d\u6a21\u578b\u8868\u660e\uff0cTEV\u76f4\u63a5\u53c2\u4e0e\u6297\u539f\u5448\u9012\uff0c\u5e76\u53c2\u4e0e\u8f90\u5c04\u8bf1\u5bfc\u7684DNA\u635f\u4f24\u4fe1\u53f7\u7684\u4f20\u5bfc\u3002\u8fd9\u4e9bTEV\u7684\u76f4\u63a5\u548c\u95f4\u63a5\u4fee\u9970\u90fd\u53ef\u4ee5\u6539\u53d8CRC\u514d\u75ab\u539f\u6027\u548cICI\u6cbb\u7597\u6548\u679c\uff0c\u4f7f\u5f97TEV\u4fee\u9970\u6210\u4e3a\u6f5c\u5728\u7684\u5f00\u53d1\u6cbb\u7597\u836f\u7269\u7684\u9776\u6807\u3002\u6b64\u5916\uff0c\u53ef\u4ee5\u4f7f\u7528\u51e0\u79cd\u4e0d\u540c\u7684\u65b9\u5f0f\u5f00\u53d1\u4fee\u9970\u540e\u7684TEV\uff0c\u5305\u62ecmicro-RNA\u548c\u5c0f\u80bd\u5206\u5b50\u3002\u6700\u8fd1\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u4e34\u5e8a\u524d\u8bc1\u636e\uff1a\u6ce8\u5c04\u4fee\u9970\u7684TEV\u53ef\u8bf1\u5bfcICI\u7684\u6d3b\u6027\uff0cTEV\u4e2dmicro-RNA miR-424\u7684\u6572\u4f4e\u6539\u5584\u4e86\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684CRC\u514d\u75ab\u539f\u6027\u5e76\u589e\u52a0\u4e86\u6297PD-1\u6d3b\u6027\u3002\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u4e3a\u8bc4\u4f30\u4fee\u9970\u540eTEV\u5bf9\u764c\u75c7\u6cbb\u7597\u7684\u6548\u679c\uff0c\u76f8\u5e94\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002TEV\u6709\u671b\u6210\u4e3aCRC\u7684\u65b0\u7684\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u7ed3\u76f4\u80a0\u764c\uff1b\u514d\u75ab\u7597\u6cd5\uff1b\u80bf\u7624\u884d\u751f\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\uff1bmicro-RNA<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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08<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Metab. 20221212<\/strong><\/p>\n<\/section>\n<\/section>\n

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Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer<\/strong><\/p>\n

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Cell Metab. 2022 Dec 12;S1550-4131(22)00504-6.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cmet.2022.11.013.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36528023\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u8fc4\u4eca\u4e3a\u6b62\u4ecd\u7f3a\u4e4f\u665a\u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u6709\u6548\u6cbb\u7597\u624b\u6bb5\u3002\u7531\u4e8e\u4ee3\u8c22\u7684\u6539\u53d8\u548c\u4e0e\u5fae\u751f\u7269\u7fa4\u7684\u63a5\u89e6\uff0cCRC\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5b58\u5728\u4ee3\u8c22\u5e9f\u7269\u7684\u79ef\u805a\u3002\u800c\u4ee3\u8c22\u5e9f\u7269\u5728\u80bf\u7624\u53d1\u5c55\u3001\u8fdb\u5c55\u548c\u6cbb\u7597\u62b5\u6297\u4e2d\u7684\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002\u6211\u4eec\u5f00\u53d1\u4e86\u4e00\u4e2a\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u81ea\u4f53\u8f6c\u79fb\u5c0f\u9f20\u6a21\u578b\uff0c\u5e76\u4f7f\u7528\u65e0\u504f\u501a\u7684\u591a\u7ec4\u5b66\u5206\u6790\u63ed\u793a\u4e86\u80bf\u7624\u4e2d\u6c28\u7684\u660e\u663e\u7d2f\u79ef\u3002\u9ad8\u6d53\u5ea6\u7684\u6c28\u8bf1\u5bfc\u4e86T\u7ec6\u80de\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff0c\u589e\u52a0T\u7ec6\u80de\u7684\u8870\u7aed\uff0c\u5e76\u51cf\u5c11\u4e86T\u7ec6\u80de\u589e\u6b96\u3002\u764c\u75c7\u60a3\u8005\u7684\u8840\u6e05\u6c28\u589e\u52a0\u3001\u6c28\u76f8\u5173\u7684\u57fa\u56e0\u7279\u5f81\u4e0eT\u7ec6\u80de\u53cd\u5e94\u7684\u6539\u53d8\u3001\u60a3\u8005\u7684\u4e0d\u826f\u540e\u679c\u4ee5\u53ca\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u8010\u53d7\u6709\u5173\u3002\u6211\u4eec\u8bc1\u660e\uff0c\u901a\u8fc7\u6c28\u7684\u6e05\u9664\u53ef\u4ee5\u91cd\u65b0\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u51cf\u5c11\u80bf\u7624\u7684\u751f\u957f\uff0c\u5e76\u5ef6\u957f\u751f\u5b58\u671f\u3002\u6b64\u5916\uff0c\u51cf\u5c11\u80bf\u7624\u76f8\u5173\u7684\u6c28\u589e\u5f3a\u4e86\u6297PD-L1\u7684\u7597\u6548\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u52a0\u5f3a\u6c28\u7684\u89e3\u6bd2\u53ef\u4ee5\u91cd\u65b0\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u8fd9\u5f88\u53ef\u80fd\u6210\u4e3a\u63d0\u9ad8\u514d\u75ab\u7597\u6cd5\u7597\u6548\u7684\u4e00\u79cd\u65b0\u65b9\u6cd5\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u6c28\uff1b\u80bf\u7624\u4ee3\u8c22\uff1b\u514d\u75ab\u6cbb\u7597\uff1b\u80bf\u7624\u5fae\u73af\u5883<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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09<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Commun. 20221212<\/strong><\/p>\n<\/section>\n<\/section>\n

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PRDM1\/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells<\/strong><\/p>\n

PRDM1\/BLIMP1\u5728\u809d\u764c\u7ec6\u80de\u4e2d\u901a\u8fc7\u8c03\u8282\u7684USP22-SPI1-PD-L1\u8f74\u8bf1\u5bfc\u80bf\u7624\u514d\u75ab\u9003\u9038<\/strong><\/span><\/p>\n

Nat Commun. 2022 Dec 12;13(1):7677.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-022-35469-x.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36509766\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53-1 (PD-1)\u963b\u65ad\u5df2\u7ecf\u53d6\u5f97\u4e86\u4e00\u4e9b\u7597\u6548\uff0c\u4f46\u4ec5\u5728\u4e00\u5c0f\u90e8\u5206\u809d\u7ec6\u80de\u764c(HCC)\u60a3\u8005\u4e2d\u6709\u6548\u679c\u3002\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u914d\u4f531 (PD-L1)\u4e0eT\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53PD1\u7ed3\u5408\u4ee5\u6291\u5236\u6297\u539f\u7279\u5f02\u6027\u7684\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u7136\u800c\uff0cPD-L1\u8c03\u63a7\u7684\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u9610\u660e\u3002\u5728\u6b64\uff0c\u6211\u4eec\u53d1\u73b0\u80bf\u7624Prdm1\u7684\u8fc7\u8868\u8fbe\u6291\u5236\u4e86\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u6a21\u578b\u7684\u80bf\u7624\u7ec6\u80de\u751f\u957f\u3002\u6b64\u5916\uff0c\u80bf\u7624Prdm1\u7684\u8fc7\u8868\u8fbe\u4f1a\u4e0a\u8c03PD-L1\u7684\u6c34\u5e73\uff0c\u6291\u5236\u4f53\u5185\u7684\u6297\u80bf\u7624\u514d\u75ab\u529b\uff0c\u5e76\u4e2d\u548c\u4e86Prdm1\u8fc7\u8868\u8fbe\u5728\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u6297\u80bf\u7624\u529f\u6548\u3002\u673a\u5236\u4e0a\uff0cPRDM1\u589e\u5f3aUSP22\u7684\u8f6c\u5f55\uff0c\u4ece\u800c\u901a\u8fc7\u53bb\u6cdb\u7d20\u5316\u51cf\u5c11\u4e86SPI1\u86cb\u767d\u7684\u964d\u89e3\uff0c\u4ece\u800c\u589e\u5f3a\u4e86PD-L1\u7684\u8f6c\u5f55\u3002\u5728\u529f\u80fd\u4e0a\uff0c\u5728\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u7684\u5c0f\u9f20\u809d\u764c\u6a21\u578b\u4e2d\uff0cprdm1\u8fc7\u8868\u8fbe\u589e\u5f3a\u4e86PD-1\u5355\u6297\u6cbb\u7597\u7684\u6548\u679c\u3002\u603b\u4e4b\uff0c \u672c\u7814\u7a76\u8bc1\u660e\u4e86PRDM1-USP22-SPI1\u8f74\u53ef\u8c03\u8282PD-L1\u7684\u6c34\u5e73\uff0c\u5bfc\u81f4\u6d78\u6da6\u6027CD8+T\u7ec6\u80de\u8017\u7aed\u3002\u6b64\u5916\uff0cPRDM1\u8fc7\u8868\u8fbe\u8054\u5408PD-(L)1 mAb\u6cbb\u7597\u4e3aHCC\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10<\/strong><\/p>\n<\/section>\n<\/section>\n

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Semin Cancer Biol. 20221207<\/strong><\/p>\n<\/section>\n<\/section>\n

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Targeting lactate metabolism for cancer immunotherapy – a matter of precision<\/strong><\/p>\n

\u9776\u5411\u4e73\u9178\u4ee3\u8c22\u8fdb\u884c\u764c\u75c7\u514d\u75ab\u6cbb\u7597 – \u7cbe\u5ea6\u95ee\u9898<\/strong><\/span><\/p>\n

Semin Cancer Biol. 2022 Dec 7;88:32-45.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.semcancer.2022.12.001.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36496155\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u548c\u8fc7\u7ee7\u6027T\u7ec6\u80de\u7597\u6cd5\u5df2\u7ecf\u6210\u4e3a\u6297\u51fb\u764c\u75c7\u7684\u91cd\u8981\u8f85\u52a9\u5de5\u5177\u3002\u8fd9\u4e9b\u6cbb\u7597\u65b9\u6cd5\u4f7f\u6709\u671b\u6062\u590d\u65e0\u764c\u75c7\u751f\u6d3b\u7684\u60a3\u8005\u6570\u91cf\u6781\u5927\u589e\u52a0\u3002\u7136\u800c\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u5728\u4e00\u4e9b\u60a3\u8005\u548c\u5b9e\u4f53\u80bf\u7624\u4e2d\u8fc4\u4eca\u4ecd\u7136\u65e0\u6548\u3002\u5728\u5b9e\u4f53\u7624\u4e2d\uff0c\u5f71\u54cd\u6cbb\u7597\u6548\u679c\u7684\u5b9e\u8d28\u6027\u56e0\u7d20\u662f\u514d\u75ab\u6392\u65a5\u548c\u514d\u75ab\u6291\u5236\u6027\u7684\u80bf\u7624\u5fae\u73af\u5883\u3002\u80bf\u7624\u4e2d\u514d\u75ab\u7ec6\u80de\u6297\u80bf\u7624\u6d3b\u6027\u4f4e\u4e0b\u7684\u4e00\u4e2a\u4e3b\u8981\u56e0\u7d20\u662f\u5b83\u4eec\u5e38\u5904\u4e8e\u6076\u52a3\u7684\u4ee3\u8c22\u73af\u5883\u3002\u7f3a\u6c27\u3001\u4e0e\u80bf\u7624\u548c\u57fa\u8d28\u7ec6\u80de\u7684\u8425\u517b\u7ade\u4e89\uff0c\u4ee5\u53ca\u5305\u62ec\u4e73\u9178\u5728\u5185\u7684\u6709\u5bb3\u5e9f\u7269\u7684\u7d2f\u79ef\uff0c\u8fd9\u4e9b\u56e0\u7d20\u90fd\u5bf9\u6297\u80bf\u7624\u7684\u514d\u75ab\u7ec6\u80de\u4ea7\u751f\u4e86\u5de8\u5927\u7684\u5f71\u54cd\u3002\u76ee\u524d\u8bb8\u591a\u6297\u80bf\u7624\u6cbb\u7597\u7b56\u7565\u5bc4\u5e0c\u671b\u4e8e\u627e\u51fa\u80bf\u7624\u7ec6\u80de\u7684\u4ee3\u8c22\u7f3a\u9677\uff0c\u901a\u8fc7\u6539\u5584\u5b83\u4eec\u6765\u51cf\u8f7b\u4ee3\u8c22\u5f15\u8d77\u7684\u514d\u75ab\u6291\u5236\u3002\u8fd9\u79cd\u5c1d\u8bd5\u867d\u7136\u4ece\u7406\u8bba\u4e0a\u6765\u770b\u5f88\u6709\u5e0c\u671b\uff0c\u7279\u522b\u662f\u53ef\u4ee5\u4e0e\u514d\u75ab\u7597\u6cd5\u76f8\u7ed3\u5408\uff0c\u4f46\u9700\u8981\u4ed4\u7ec6\u7814\u7a76\u8fd9\u4e9b\u7b56\u7565\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u7684\u5f71\u54cd\uff0c\u56e0\u4e3a\u514d\u75ab\u7ec6\u80de\u4e0e\u80bf\u7624\u7ec6\u80de\u6709\u4e00\u4e9b\u5171\u540c\u7684\u91cd\u8981\u4ee3\u8c22\u7279\u6027\u3002\u5728\u6b64\uff0c\u6211\u4eec\u7efc\u8ff0\u4e86\u90a3\u4e9b\u901a\u8fc7\u5bfb\u6c42\u89e3\u51b3\u80bf\u7624\u6216\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u4e73\u9178\u5806\u79ef\u73b0\u8c61\u4ee5\u6539\u5584\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ece\u800c\u4e3a\u90a3\u4e9b\u76ee\u524d\u65e0\u6cd5\u6cbb\u7597\u7684\u80bf\u7624\u60a3\u8005\u5f00\u8f9f\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u9178\u5316\uff1b\u8fc7\u7ee7\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\uff1b\u7cd6\u9175\u89e3\uff1b\u514d\u75ab\u7597\u6cd5\uff1b\u4e73\u9178\uff1b\u4ee3\u8c22<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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11<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Rev Cancer. 2022120<\/strong><\/p>\n<\/section>\n<\/section>\n

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Biology, vulnerabilities and clinical applications of circulating tumour cells<\/strong><\/p>\n

\u5faa\u73af\u80bf\u7624\u7ec6\u80de\u7684\u751f\u7269\u5b66\u7279\u5f81\u3001\u6613\u611f\u6027\u548c\u4e34\u5e8a\u5e94\u7528<\/strong><\/span><\/p>\n

Nat Rev Cancer. 2022 Dec 9;1-17.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41568-022-00536-4.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36494603\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u6280\u672f\u8fdb\u6b65\u4f7f\u5f97\u6211\u4eec\u80fd\u591f\u4ece\u60a3\u8005\u7684\u8840\u6db2\u6837\u672c\u4e2d\u8bc6\u522b\u548c\u5bfb\u627e\u7f55\u89c1\u7684\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff08CTC\uff09\uff0c\u8fd9\u5f00\u8f9f\u4e86\u65b0\u7684\u7814\u7a76\u9886\u57df\uff0c\u5e76\u4e3a\u57fa\u4e8e\u6db2\u4f53\u6d3b\u68c0\u7684\u4e34\u5e8a\u5e94\u7528\u5e26\u6765\u4e86\u5e0c\u671b\u3002CTC\u7684\u5206\u6790\u63ed\u793a\u4e86\u4e0d\u540c\u7684\u751f\u7269\u5b66\u8868\u578b\uff0c\u5305\u62ecCTC\u7c07\u7684\u5b58\u5728\u4ee5\u53caCTC\u4e0e\u514d\u75ab\u6216\u57fa\u8d28\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5f71\u54cd\u8f6c\u79fb\u5f62\u6210\uff0c\u5e76\u4e3a\u764c\u75c7\u6613\u611f\u6027\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u56de\u987e\u4e86CTC\u751f\u7269\u5b66\u7279\u5f81\u65b9\u9762\u53d6\u5f97\u7684\u8fdb\u5c55\uff0c\u5e76\u4e3a\u5229\u7528\u8fd9\u4e9b\u53d1\u5c55\u6765\u8bbe\u8ba1\u672a\u6765\u7684\u4e34\u5e8a\u5de5\u5177\u4ee5\u6539\u8fdb\u764c\u75c7\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u63d0\u4f9b\u4e86\u89c1\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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12<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Extracell Vesicles. 20221209<\/strong><\/p>\n<\/section>\n<\/section>\n

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Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels<\/strong><\/p>\n

\u6291\u5236PD-L1\u4ece\u5916\u6ccc\u4f53\u4e2d\u91ca\u653e\u53ef\u901a\u8fc7\u9776\u5411ORAI1\u9499\u901a\u9053\u589e\u5f3a\u5168\u8eab\u6027\u6297\u80bf\u7624\u514d\u75ab\u529b<\/strong><\/span><\/p>\n

J Extracell Vesicles. 2022 Dec;11(12):e12279.<\/em><\/p>\n

doi: <\/strong>10.1002\/jev2.12279.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36482876\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u4f5c\u4e3a\u764c\u7ec6\u80de\u514b\u670d\u514d\u75ab\u53cd\u5e94\u7684\u4e00\u79cd\u7b56\u7565\uff0c\u6700\u8fd1\u5728\u764c\u75c7\u7814\u7a76\u9886\u57df\u5f97\u5230\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002\u7279\u522b\u662f\u5404\u79cd\u764c\u7ec6\u80de\u5bf9PD-L1\u7684\u8868\u8fbe\u8c03\u63a7\u5df2\u7ecf\u6210\u4e3a\u70ed\u95e8\u7814\u7a76\u65b9\u5411\u3002PD-L1\u53ef\u901a\u8fc7\u5c40\u90e8\u6269\u6563\u6216\u901a\u8fc7\u7ec6\u80de\u5916\u5c0f\u6ce1\uff08sEVs\uff0c\u901a\u5e38\u88ab\u79f0\u4e3a\u5916\u6ccc\u4f53\uff09\u7684\u8fd0\u8f93\u5230\u8fbe\u5176\u4f5c\u7528\u90e8\u4f4d\u3002\u8fc4\u4eca\u5df2\u5bf9sEVs\u7684\u5f62\u6210\u3001\u4e0ePD-L1\u7684\u5305\u88c5\u548c\u91ca\u653e\u5230\u7ec6\u80de\u5916\u7a7a\u95f4\u7684\u8bb8\u591a\u6b65\u9aa4\u8fdb\u884c\u4e86\u8be6\u7ec6\u7684\u7814\u7a76\u3002\u7136\u800c\uff0cPD-L1\u53ef\u80fd\u901a\u8fc7Ca2+\u4fe1\u53f7\u4f9d\u8d56\u7684\u65b9\u5f0f\u91ca\u653e\u5374\u5f88\u5c11\u53d7\u5230\u5173\u6ce8\u3002\u8fd9\u662f\u4ee4\u4eba\u60ca\u8bb6\u7684\uff0c\u56e0\u4e3a\u7ec6\u80de\u5185\u7684Ca2+\u6d53\u5ea6\u88ab\u8ba4\u4e3a\u662f\u8bb8\u591a\u5206\u6ccc\u8fc7\u7a0b\u7684\u4e00\u4e2a\u91cd\u8981\u8c03\u8282\u56e0\u7d20\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u62a5\u9053\u4e86\u4e09\u79cdCa2+\u4f9d\u8d56\u6027\u86cb\u767d\u5728\u8c03\u8282\u542bPD-L1\u7684sEVs\u91ca\u653e\u4e2d\u7684\u4f5c\u7528\uff0c\u4ee5\u53ca\u5bf9\u5c0f\u9f20\u6a21\u578b\u4e2d\u80bf\u7624\u751f\u957f\u60c5\u51b5\u7684\u5f71\u54cd\u3002\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u764c\u7ec6\u80de\u7cfb\u4e2d\u7684sEVs\u91ca\u653e\u662fCa2+\u4f9d\u8d56\u6027\u7684\uff0c\u7f16\u7801Ca2+\u901a\u9053\u86cb\u767dORAI1\u7684\u57fa\u56e0\u88ab\u6572\u9664\u540e\uff0c\u4f1a\u51cf\u5c11Ca2+\u4fe1\u53f7\u548csEVs\u7684\u91ca\u653e\u3002\u56e0\u6b64\uff0cT\u7ec6\u80de\u53cd\u5e94\u88ab\u91cd\u65b0\u6fc0\u6d3b\uff0c\u5c0f\u9f20\u6a21\u578b\u4e2d\u80bf\u7624\u8fdb\u5c55\u88ab\u5ef6\u7f13\u3002\u6b64\u5916\uff0c\u5bf9\u4eba\u7c7b\u764c\u75c7\u7ec4\u7ec7\u6837\u672c\u7684\u86cb\u767d\u8d28\u8868\u8fbe\u6a21\u5f0f\u7684\u5206\u6790\u8868\u660e\uff0cORAI1\u57fa\u56e0\u660e\u663e\u4e0a\u8c03\u3002\u8fd9\u79cd\u4e0a\u8c03\u88ab\u786e\u5b9a\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u751f\u5b58\u7684\u4e00\u4e2a\u4e0d\u5229\u7684\u9884\u540e\u56e0\u7d20\u3002\u6211\u4eec\u8868\u660e\uff0c\u6572\u4f4eORAI1\u57fa\u56e0\u540e\uff0cCa2+\u4fe1\u53f7\u7684\u51cf\u5c11\u4e5f\u6291\u5236\u4e86\u55dc\u9ed1\u7d20\u548cSynaptotagmin\u6837\u86cb\u767d2\u7684\u6d3b\u6027\uff0c\u8fd9\u4e24\u79cd\u86cb\u767d\u5bf9\u4e8e\u5206\u6ccc\u7ec6\u80de\u5668\u5728\u764c\u7ec6\u80de\u5185\u7684\u6b63\u786e\u5b9a\u4f4d\u4ee5\u53ca\u5c06\u5176\u8fd0\u9001\u5230\u5916\u5206\u6ccc\u90e8\u4f4d\u975e\u5e38\u91cd\u8981\u3002\u56e0\u6b64\uff0cCa2+\u901a\u9053ORAI1\u548c\u5206\u6ccc\u9014\u5f84\u7684Ca2+\u4f9d\u8d56\u6027\u86cb\u767d\u6210\u4e3a\u4e86\u7814\u7a76\u548c\u63a7\u5236PD-L1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u91cd\u8981\u76ee\u6807\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

Ca2+; ORAI1; PD-L1; \u5916\u6ccc\u4f53; \u80ba\u764c<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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13<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Rev Immunol. 20221208<\/strong><\/p>\n<\/section>\n<\/section>\n

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CRISPR screens for functional interrogation of immunity<\/strong><\/p>\n

\u514d\u75ab\u529f\u80fd\u76f8\u5173\u7684CRISPR\u7b5b\u9009<\/strong><\/span><\/p>\n

Nat Rev Immunol. 2022 Dec 8.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41577-022-00802-4.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36481809\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u57fa\u4e8eCRISPR\u7684\u6280\u672f\u4ee3\u8868\u4e86\u751f\u7269\u533b\u5b66\u79d1\u5b66\u7684\u4e00\u4e2a\u91cd\u5927\u7a81\u7834\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e3a\u5305\u62ec\u514d\u75ab\u5b66\u5728\u5185\u7684\u5404\u4e2a\u9886\u57df\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f3a\u5927\u7684\u5ba2\u89c2\u7684\u7b5b\u9009\u548c\u529f\u80fd\u57fa\u56e0\u7ec4\u5b66\u5e73\u53f0\u3002CRISPR\u7b5b\u67e5\u53d1\u73b0\u4e86\u4ee5\u524d\u672a\u77e5\u7684\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u7ec6\u80de\u7684\u514d\u75ab\u8c03\u8282\u7684\u7ec6\u80de\u5185\u9a71\u52a8\u56e0\u7d20\uff0c\u4ee5\u53ca\u4ecb\u5bfc\u7ec6\u80de-\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u7ec6\u80de\u95f4\u8c03\u8282\u5668\u3002\u6700\u8fd1\u7684\u5355\u7ec6\u80deCRISPR\u7b5b\u9009\u5e73\u53f0\u5c06\u8bfb\u6570\u6269\u5c55\u5230\u4e86\u8f6c\u5f55\u7ec4\uff0c\u5e76\u80fd\u63a8\u65ad\u51fa\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff0c\u8fd9\u4f7f\u63a2\u7a76\u66f4\u8be6\u7ec6\u7684\u673a\u5236\u6210\u4e3a\u53ef\u80fd\u3002CRISPR\u7b5b\u67e5\u8fd8\u5141\u8bb8\u7ed8\u5236\u9057\u4f20\u76f8\u4e92\u4f5c\u7528\u56fe\uff0c\u4ee5\u786e\u5b9a\u534f\u540c\u6216\u51cf\u8f7b\u590d\u6742\u514d\u75ab\u8868\u578b\u7684\u57fa\u56e0\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u56de\u987e\u4e86CRISPR\u6280\u672f\u7684\u8fdb\u5c55\u548c\u65b0\u5174\u7684\u9002\u7528\u9886\u57df\uff0c\u4ee5\u63a8\u8fdb\u6211\u4eec\u7684\u57fa\u7840\u514d\u75ab\u5b66\u77e5\u8bc6\uff0c\u5e76\u4e3a\u611f\u67d3\u3001\u708e\u75c7\u548c\u764c\u75c7\u7684\u514d\u75ab\u7597\u6cd5\u786e\u5b9a\u65b0\u7684\u76ee\u6807\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14<\/strong><\/p>\n<\/section>\n<\/section>\n

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N Engl J Med. 20221208<\/strong><\/p>\n<\/section>\n<\/section>\n

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Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma<\/strong><\/p>\n

\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u6cbb\u7597\u6216\u4f0a\u5339\u5355\u6297\u6cbb\u7597<\/strong><\/span><\/p>\n

N Engl J Med. 2022 Dec 8;387(23):2113-2125.<\/em><\/p>\n

doi: <\/strong>10.1056\/NEJMoa2210233.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36477031\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80cc\u666f\uff1a<\/strong>\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u548c\u9776\u5411\u6cbb\u7597\u663e\u8457\u6539\u5584\u4e86\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u9884\u540e\uff0c\u4f46\u8fd9\u4e9b\u60a3\u8005\u4e2d\u7ea6\u6709\u4e00\u534a\u4e0d\u4f1a\u6709\u6301\u4e45\u7684\u7597\u6548\u3002\u91c7\u7528\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u8fdb\u884c\u8fc7\u7ee7\u7ec6\u80de\u6cbb\u7597\u76841-2\u671f\u8bd5\u9a8c\u7ed3\u679c\u9884\u793a\u7740\u53ef\u80fd\u6709\u6548\uff0c\u4f46\u7f3a\u4e4f3\u671f\u8bd5\u9a8c\u7684\u6570\u636e\u6765\u786e\u5b9aTIL\u5728\u6cbb\u7597\u665a\u671f\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/strong>\u5728\u8fd9\u98793\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u7684\u8bd5\u9a8c\u4e2d\uff0c\u6211\u4eec\u4ee51:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u4e0d\u53ef\u5207\u9664\u7684IIIC\u6216IV\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a5\u53d7TIL\u6216\u6297\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f4\u7597\u6cd5\uff08\u6bcf\u516c\u65a4\u4f53\u91cd3\u6beb\u514b\u7684\u4f0a\u5339\u5355\u6297\uff09\u3002\u5728\u8f93\u6ce8\u81f3\u5c115\u00d7109\u4e2aTILs\u4e4b\u524d\uff0c\u5148\u8fdb\u884c\u975e\u53bb\u9ad3\u5316\u7597\u3001\u53bb\u6dcb\u5df4\u5316\u7597\uff08\u73af\u78f7\u9170\u80fa\u52a0\u6c1f\u8fbe\u62c9\u6ee8\uff09\uff0c\u7136\u540e\u518d\u8fdb\u884c\u5927\u5242\u91cf\u767d\u7ec6\u80de\u4ecb\u7d20-2\u51b2\u51fb\u3002\u5224\u65ad\u8bd5\u9a8c\u7ed3\u679c\u7684\u4e3b\u8981\u89c2\u5bdf\u7ec8\u70b9\u662f\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002<\/p>\n

\u7ed3\u679c\uff1a<\/strong>\u5171\u6709168\u540d\u60a3\u8005\uff0886%\u60a3\u6709\u5bf9\u6297PD-1\u7597\u6cd5\u65e0\u6548\uff09\u88ab\u5206\u914d\u63a5\u53d7TIL\uff0884\u540d\u60a3\u8005\uff09\u6216\u4f0a\u5339\u5355\u6297\u6cbb\u7597\uff0884\u4f8b\u60a3\u8005\uff09\u3002\u5728\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\u4e2d\uff0cTIL\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a7.2\u4e2a\u6708\uff0895%\u53ef\u4fe1\u533a\u95f4[CI]\uff0c4.2\u81f313.1\uff09\uff0c\u4f0a\u5339\u5355\u6297\u7ec4\u4e3a3.1\u4e2a\u6708\uff0895%CI\uff0c3.0\u81f34.3\uff09\uff08\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u6bd4\uff0c0.50\uff1b95%CI\uff0c0.35\u81f30.72\uff1bP<0.001\uff09\uff1b49%\uff0895%\u53ef\u4fe1\u533a\u95f4\uff0c38\u81f360\uff09\u548c21%\uff0895%\u7f6e\u4fe1\u533a\u95f4\uff0c13\u81f332\uff09\u7684\u60a3\u8005\u6709\u5ba2\u89c2\u53cd\u5e94\u3002TIL\u7ec4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a25.8\u4e2a\u6708\uff0895%\u53ef\u4fe1\u533a\u95f4\uff0c18.2\u81f3\u672a\u8fbe\u5230\uff09\uff0c\u4f0a\u666e\u5229\u5355\u6297\u7ec4\u4e3a18.9\u4e2a\u6708\uff0895%CI\uff0c13.8\u81f332.6\uff09\u3002\u6240\u6709\u63a5\u53d7TIL\u7684\u60a3\u8005\u548c57%\u63a5\u53d7\u4f0a\u5339\u5355\u6297\u7684\u60a3\u8005\u53d1\u751f\u4e863\u7ea7\u6216\u66f4\u9ad8\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff1b\u5728TIL\u7ec4\u4e2d\uff0c\u8fd9\u4e9b\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u662f\u5316\u7597\u76f8\u5173\u7684\u9aa8\u9ad3\u6291\u5236\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/strong>\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u63a5\u53d7TIL\u6cbb\u7597\u7684\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u660e\u663e\u957f\u4e8e\u63a5\u53d7\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u3002\uff08\u7531\u8377\u5170\u764c\u75c7\u534f\u4f1a\u7b49\u8d44\u52a9\uff1bClinicalTrials.gov number, NCT02278887\u3002\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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15<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Commun. 20221207<\/strong><\/p>\n<\/section>\n<\/section>\n

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Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer<\/strong><\/p>\n

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Nat Commun.2022 Dec 7;13(1):7533.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-022-35291-5.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36476645\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

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16<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20221205<\/strong><\/p>\n<\/section>\n<\/section>\n

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Dendritic cells direct circadian anti-tumour immune responses<\/strong><\/p>\n

\u6811\u7a81\u72b6\u7ec6\u80de\u8c03\u63a7\u663c\u591c\u8282\u5f8b\u6027\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94<\/strong><\/span><\/p>\n

Nature. 2022 Dec 5.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-022-05605-0.<\/p>\n

PubMed: <\/strong>https:\/\/pubmed.ncbi.nlm.nih.gov\/36470303\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

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\u2014 THE  END \u2014<\/span><\/section>\n
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\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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