{"id":5015,"date":"2023-06-23T20:27:43","date_gmt":"2023-06-23T12:27:43","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/06\/23\/monthly-updates-2023-04\/"},"modified":"2025-01-03T18:49:39","modified_gmt":"2025-01-03T10:49:39","slug":"monthly-updates-2023-04","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/06\/23\/monthly-updates-2023-04\/","title":{"rendered":"Monthly Updates 2023.04"},"content":{"rendered":"
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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20230405<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells<\/strong><\/p>\n

NK\u7ec6\u80de\u53d7\u4f53NKp46\u53ef\u8bc6\u522b\u5185\u8d28\u7f51\u5e94\u6fc0\u7ec6\u80de\u4e0a\u7684\u5916\u6e90\u6027\u9499\u7f51\u86cb\u767d<\/strong><\/span><\/p>\n

Nature. 2023 Apr 5.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-05912-0.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37020026\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u5728\u6fc0\u6d3b\u578bNK\u7ec6\u80de\u53d7\u4f53\u88ab\u89e6\u53d1\u65f6\u6740\u6b7b\u611f\u67d3\u3001\u8f6c\u5316\u548c\u5e94\u6fc0\u7684\u7ec6\u80de\u3002\u5927\u591a\u6570NK\u7ec6\u80de\u548c\u4e00\u4e9b\u5148\u5929\u6027\u6dcb\u5df4\u7ec6\u80de\u8868\u8fbe\u7531NCR1\u7f16\u7801\u7684\u6fc0\u6d3b\u53d7\u4f53NKp46\uff0c\u8fd9\u662f\u6700\u53e4\u8001\u7684NK\u7ec6\u80de\u53d7\u4f53\u3002\u963b\u65adNKp46\u6291\u5236\u4e86\u8bb8\u591a\u764c\u75c7\u9776\u7ec6\u80de\u7684NK\u7ec6\u80de\u6740\u4f24\u4f5c\u7528\u3002\u5c3d\u7ba1\u5df2\u7ecf\u9274\u5b9a\u51fa\u4e00\u4e9b\u611f\u67d3\u6027NKp46\u914d\u4f53\uff0c\u4f46\u5185\u6e90\u6027NKp46\u7ec6\u80de\u8868\u9762\u914d\u4f53\u5c1a\u672a\u77e5\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5c55\u793aNKp46\u8bc6\u522b\u5185\u8d28\u7f51\uff08ER\uff09\u5728\u5e94\u6fc0\u8fc7\u7a0b\u4e2d\u4ece\u5185\u8d28\u7f51\u8f6c\u79fb\u5230\u7ec6\u80de\u819c\u4e0a\u7684\u5916\u6e90\u6027\u9499\u7f51\u86cb\u767d\uff08ecto-CRT\uff09\u3002\u5185\u8d28\u7f51\u5e94\u6fc0\u548cecto-CRT\u662f\u5316\u7597\u8bf1\u5bfc\u7684\u514d\u75ab\u7ec6\u80de\u6b7b\u4ea1\u3001\u9ec4\u75c5\u6bd2\u611f\u67d3\u548c\u8870\u8001\u7684\u7279\u5f81\u3002NKp46\u8bc6\u522becto-CRT\u7684P\u7ed3\u6784\u57df\u89e6\u53d1NK\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\uff0c\u5e76\u5728NK\u514d\u75ab\u7a81\u89e6\u4e2d\u4e0eecto-CRT\u4e00\u8d77\u53d1\u751f\u805a\u96c6\u3002\u901a\u8fc7\u6572\u9664\u6216\u6572\u4f4e\u7f16\u7801CRT\u7684CALR\u57fa\u56e0\u6216CRT\u6297\u4f53\u6291\u5236NKp46\u4ecb\u5bfc\u7684\u6740\u4f24\u4f5c\u7528\uff0c\u800c\u901a\u8fc7\u8868\u8fbe\u7cd6\u57fa\u78f7\u8102\u9170\u808c\u9187\u951a\u5b9a\u7684CRT\u589e\u5f3a\u8be5\u4f5c\u7528\u3002\u7f3a\u4e4fNCR1\u7684\u4eba\u7c7b\uff08\u548c\u7f3a\u4e4fNrc1\u7684\u5c0f\u9f20\uff09NK\u7ec6\u80de\u5728\u6740\u6b7bZIKV\u611f\u67d3\u7684\u3001\u5185\u8d28\u7f51\u5e94\u6fc0\u7684\u3001\u8870\u8001\u7ec6\u80de\u548c\u8868\u8fbeecto-CRT\u7684\u764c\u7ec6\u80de\u65b9\u9762\u53d7\u635f\u3002\u91cd\u8981\u7684\u662f\uff0cNKp46\u5bf9ecto-CRT\u7684\u8bc6\u522b\u63a7\u5236\u4e86\u5c0f\u9f20B16\u9ed1\u8272\u7d20\u7624\u548cRAS\u9a71\u52a8\u7684\u80ba\u764c\uff0c\u5e76\u589e\u5f3a\u4e86\u80bf\u7624\u6d78\u6da6NK\u7ec6\u80de\u7684\u9897\u7c92\u9176\u91ca\u653e\u548c\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\u3002\u56e0\u6b64\uff0cNKp46\u8bc6\u522becto-CRT\u4f5c\u4e3a\u5371\u9669\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\u6d88\u9664\u5185\u8d28\u7f51\u5e94\u6fc0\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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02<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gut. 20230405<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma<\/strong><\/p>\n

\u9776\u5411PPAR-\u03b3\u53ef\u6d88\u9664\u809d\u7ec6\u80de\u764c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u8010\u53d7<\/strong><\/span><\/p>\n

Gut. 2023 Apr 5;gutjnl-2022-328364.<\/em><\/p>\n

doi: <\/strong>10.1136\/gutjnl-2022-328364.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37019619\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u76ee\u7684\uff1a<\/strong>\u6cbb\u7597\u8bf1\u5bfc\u7684\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u91cd\u5851\u5bf9\u764c\u75c7\u6cbb\u6108\u6784\u6210\u91cd\u5927\u969c\u788d\u3002\u7531\u4e8e\u5927\u591a\u6570\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u5bf9\u6297\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff08\u914d\u4f53\uff09-1\uff08\u6297-PD-[L]1\uff09\u7597\u6cd5\u8868\u73b0\u51fa\u539f\u53d1\u6027\u6216\u83b7\u5f97\u6027\u62b5\u6297\uff0c\u6211\u4eec\u65e8\u5728\u7814\u7a76\u80bf\u7624\u9002\u5e94\u514d\u75ab\u68c0\u67e5\u70b9\u9776\u5411\u6cbb\u7597\u7684\u673a\u5236\u3002<\/p>\n

\u8bbe\u8ba1\uff1a<\/strong>\u901a\u8fc7\u5728\u6297PD-L1\u5904\u7406\u7684\u540c\u7cfb\u57fa\u56e0\u578b\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u5c0f\u9f20\u4e2d\u8fdb\u884c\u8fde\u7eed\u6b63\u4ea4\u79cd\u690dHCC\u7ec6\u80de\uff0c\u751f\u6210\u4e24\u79cd\u514d\u75ab\u6cbb\u7597\u8010\u836fHCC\u6a21\u578b\uff0c\u5e76\u901a\u8fc7\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u3001\u57fa\u56e0\u7ec4\u548c\u514d\u75ab\u5206\u6790\u8fdb\u884c\u7814\u7a76\u3002\u901a\u8fc7\u6162\u75c5\u6bd2\u4ecb\u5bfc\u7684\u6572\u4f4e\u548c\u836f\u7406\u5b66\u6291\u5236\u7814\u7a76\u5173\u952e\u4fe1\u53f7\u901a\u8def\uff0c\u5e76\u901a\u8fc7\u5bf9\u6765\u81eapembrolizumab II\u671f\u8bd5\u9a8c\uff08NCT03419481\uff09\u7684HCC\u80bf\u7624\u6d3b\u68c0\u6837\u672c\u8fdb\u884cscRNA-seq\u5206\u6790\u8fdb\u884c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n

\u7ed3\u679c\uff1a<\/strong>\u6297PD-L1\u8010\u836f\u80bf\u7624\u5728\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u5c0f\u9f20\u4e2d\u6bd4\u4eb2\u672c\u80bf\u7624\u751f\u957f\u5927>10\u500d\uff0c\u800c\u5728\u514d\u75ab\u529f\u80fd\u53d7\u635f\u7684\u5c0f\u9f20\u4e2d\u6ca1\u6709\u660e\u663e\u7684\u57fa\u56e0\u53d8\u5316\uff0c\u8fd9\u4f34\u968f\u7740\u80bf\u7624\u5185\u9ad3\u6e90\u6027\u6291\u5236\u6027\u7ec6\u80de\uff08MDSC\uff09\u7684\u79ef\u7d2f\u3001\u7ec6\u80de\u6bd2\u6027CD8+ T\u7ec6\u80de\u7684\u8017\u7aed\u548c\u6392\u65a5\u3002\u5728\u673a\u5236\u4e0a\uff0c\u80bf\u7624\u7ec6\u80de\u5185\u6e90\u6027\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u6fc0\u6d3b\u53d7\u4f53-\u03b3\uff08PPAR\u03b3\uff09\u8f6c\u5f55\u6fc0\u6d3b\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50-A\uff08VEGF-A\uff09\u7684\u4ea7\u751f\uff0c\u4ee5\u9a71\u52a8MDSC\u6269\u5f20\u548cCD8+ T\u7ec6\u80de\u529f\u80fd\u969c\u788d\u3002\u9009\u62e9\u6027PPAR\u03b3\u62ee\u6297\u5242\u5f15\u53d1\u514d\u75ab\u6291\u5236\u81f3\u514d\u75ab\u523a\u6fc0TME\u8f6c\u6362\uff0c\u5e76\u4f7f\u6b63\u4ea4\u548c\u81ea\u53d1HCC\u6a21\u578b\u5bf9\u6297PD-L1\u6cbb\u7597\u91cd\u65b0\u654f\u611f\u3002\u91cd\u8981\u7684\u662f\uff0c40%\uff086\/15\uff09\u5bf9pembrolizumab\u8010\u836f\u7684HCC\u60a3\u8005\u8868\u73b0\u51fa\u80bf\u7624\u6027PPAR\u03b3\u8bf1\u5bfc\u3002\u6b64\u5916\uff0c\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u6297PD-\uff08L\uff091\u6cbb\u7597\u60a3\u8005\u7684\u57fa\u7ebfPPAR\u03b3\u8868\u8fbe\u8f83\u9ad8\u4e0e\u8f83\u5dee\u7684\u751f\u5b58\u7387\u76f8\u5173\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/strong>\u6211\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u80bf\u7624\u7ec6\u80de\u901a\u8fc7PPAR\u03b3\/VEGF-A\u4ecb\u5bfc\u7684TME\u514d\u75ab\u6291\u5236\u9003\u907f\u514d\u75ab\u68c0\u67e5\u70b9\u9776\u5411\u6cbb\u7597\u7684\u9002\u5e94\u6027\u8f6c\u5f55\u7a0b\u5e8f\uff0c\u4ece\u800c\u4e3a\u6297\u809d\u7ec6\u80de\u764c\u514d\u75ab\u6cbb\u7597\u8010\u836f\u6027\u63d0\u4f9b\u4e86\u4e00\u4e2a\u7b56\u7565\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u764c\u75c7\u514d\u75ab\u751f\u7269\u5b66\uff1b\u809d\u7ec6\u80de\u764c\uff1b\u514d\u75ab\u6cbb\u7597\uff1bPPAR GAMMA\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230410<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade<\/strong><\/p>\n

\u8c31\u7cfb\u8ffd\u8e2a\u63ed\u793a\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u671f\u95f4\u7684\u514b\u9686\u7956\u7ec6\u80de\u548c\u957f\u671f\u6301\u7eed\u5b58\u5728\u7684\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Apr 10;41(4):776-790.e7.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.03.009.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37001526\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u914d\u5bf9\u7684\u5355\u7ec6\u80deRNA\u548cT\u7ec6\u80de\u53d7\u4f53\u6d4b\u5e8f\uff08scRNA\/TCR-seq\uff09\u5df2\u7ecf\u4f7f\u5f97\u5728\u764c\u75c7\u4e2dT\u7ec6\u80de\u514b\u9686\u7684\u52a8\u6001\u89e3\u6790\u5ea6\u5f97\u5230\u63d0\u9ad8\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u62a5\u544a\u4e86\u5bf9187,650\u4e2aT\u7ec6\u80de\u7684scRNA\/TCR-seq\u5206\u6790\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u6765\u81ea31\u4e2a\u7ec4\u7ec7\u533a\u57df\uff0c\u5305\u62ec\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u6cbb\u7597\u540e\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u80bf\u7624\u3001\u90bb\u8fd1\u6b63\u5e38\u7ec4\u7ec7\u548c\u6dcb\u5df4\u7ed3\uff08LN\uff09\u3002\u542b\u6709\u6d3b\u7684\u764c\u7ec6\u80de\u7684\u533a\u57df\u5bcc\u96c6\u4e86\u8017\u7aed\u7684CD8+ T\u7ec6\u80de\u3001\u8c03\u8282\u6027CD4+ T\u7ec6\u80de\uff08Treg\uff09\u548c\u6ee4\u6ce1\u8f85\u52a9\u6027CD4+ T\u7ec6\u80de\uff08TFH\uff09\u3002\u901a\u8fc7\u5728\u7ec4\u7ec7\u4e4b\u95f4\u8ffd\u8e2aT\u7ec6\u80de\u514b\u9686\u578b\uff0c\u7ed3\u5408\u65b0\u6297\u539f\u7279\u5f02\u6027\u6d4b\u5b9a\uff0c\u63ed\u793a\u4e86TFH\u548c\u80bf\u7624\u7279\u5f02\u6027\u8017\u7aed\u7684CD8+ T\u7ec6\u80de\u5728\u80bf\u7624\u5f15\u6d41\u7684LN\u4e2d\u4e0eTCF7+SELL+\u7956\u7ec6\u80de\u514b\u9686\u76f8\u5173\uff0c\u5e76\u4e14\u5728\u9760\u8fd1\u80bf\u7624\u5fae\u73af\u5883\u65f6\uff0cCD8+ T\u7ec6\u80de\u3001Treg\u548cTFH\u7ec6\u80de\u7684\u8017\u7aed\u7a0b\u5ea6\u9010\u6e10\u52a0\u91cd\u3002\u6700\u540e\uff0c\u5bf9\u80bf\u7624\u7279\u5f02\u6027CD8+\u548cCD4+ T\u7ec6\u80de\u514b\u9686\u7684\u7eb5\u5411\u8ffd\u8e2a\u663e\u793a\uff0c\u5728ICB\u6cbb\u7597\u540e\u6570\u5e74\uff0c\u5b83\u4eec\u5728\u5916\u5468\u8840\u4e2d\u6301\u7eed\u5b58\u5728\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

TCF-1\u7956\u7ec6\u80de\u8017\u7aed\u578bT\u7ec6\u80de\uff1b\u8017\u7aed\u578bT\u7ec6\u80de\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff1b\u80ba\u764c\uff1b\u5355\u7ec6\u80deRNA\/TCR\u6d4b\u5e8f\uff1b\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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04<\/strong><\/p>\n<\/section>\n<\/section>\n

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Trends Cancer. 20230420<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Mouse models for immuno-oncology<\/strong><\/p>\n

\u514d\u75ab\u80bf\u7624\u5b66\u7684\u5c0f\u9f20\u6a21\u578b<\/strong><\/span><\/p>\n

Trends Cancer. 2023 Apr 20;S2405-8033(23)00041-9.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.trecan.2023.03.009.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37087398\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5b9e\u73b0\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u4e34\u5e8a\u524d\u666f\u53d7\u5230\u6211\u4eec\u5bf9\u4f53\u5185\u673a\u5236\u7684\u4e86\u89e3\u4e0d\u8db3\u4ee5\u53ca\u6cbb\u7597\u9650\u5236\u6027\u6bd2\u6027\u7684\u5f71\u54cd\u3002\u9700\u8981\u4e34\u5e8a\u524d\u4f53\u5185\u6a21\u578b\u7cfb\u7edf\u548c\u6280\u672f\u6765\u586b\u8865\u8fd9\u4e9b\u7a7a\u7f3a\uff0c\u4ee5\u514b\u670d\u514d\u75ab\u7597\u6cd5\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u9762\u4e34\u7684\u6311\u6218\u3002\u5c0f\u9f20\u901a\u5e38\u7528\u4e8e\u57fa\u7840\u548c\u8f6c\u5316\u7814\u7a76\uff0c\u4ee5\u652f\u6301\u514d\u75ab\u5e72\u9884\u624b\u6bb5\u7684\u5f00\u53d1\u548c\u6d4b\u8bd5\uff0c\u5305\u62ec\u764c\u75c7\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u73b0\u6709\u6a21\u578b\u7684\u4f18\u70b9\u548c\u5c40\u9650\u6027\u4ee5\u53ca\u672a\u6765\u7684\u53d1\u5c55\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u764c\u75c7\u514d\u75ab\u6cbb\u7597\uff1b\u534f\u540c\u4ea4\u53c9\u5c0f\u9f20\uff1b\u591a\u6837\u6027\u6742\u4ea4\u5c0f\u9f20\uff1b\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\uff1b\u4eba\u6e90\u5316\u5c0f\u9f20\uff1b\u5c0f\u9f20\u6a21\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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05<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230330-1<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants<\/strong><\/p>\n

T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u901a\u8fc7\u6fc0\u6d3b\u4e2d\u6027\u7c92\u7ec6\u80de\u6d88\u9664\u80bf\u7624\u6297\u539f\u9003\u9038\u53d8\u4f53<\/strong><\/span><\/p>\n

Cell. 2023 Mar 30;186(7):1432-1447.e17.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.03.007.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37001503\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff0c\u5305\u62ec\u8fc7\u7ee7\u6027T\u7ec6\u80de\u8f6c\u79fb\uff0c\u53ef\u80fd\u56e0\u80bf\u7624\u6f14\u53d8\u4e3a\u6297\u539f\u4e22\u5931\u53d8\u5f02\u578b\u514b\u9686\u800c\u5931\u6548\u3002\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u7684\u591a\u4e2a\u5206\u652f\u7684\u7597\u6cd5\u53ef\u80fd\u6d88\u9664\u9003\u9038\u53d8\u4f53\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5c55\u793a\u4e86\u9ed1\u7d20\u7624\u7279\u5f02\u6027CD4+ T\u7ec6\u80de\u7597\u6cd5\u7ed3\u5408OX40\u5171\u523a\u6fc0\u6216CTLA-4\u963b\u65ad\u53ef\u4ee5\u6d88\u9664\u542b\u6709\u6297\u539f\u9003\u9038\u53d8\u4f53\u7684\u9ed1\u8272\u7d20\u7624\u3002\u6b63\u5982\u9884\u671f\u7684\u90a3\u6837\uff0c\u80bf\u7624\u7279\u5f02\u6027CD4+ T\u7ec6\u80de\u5bf9\u9ed1\u7d20\u7624\u6297\u539f\u7684\u65e9\u671f\u9776\u5411\u8bc6\u522b\u662f\u5fc5\u9700\u7684\u3002\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u5b8c\u5168\u7684\u80bf\u7624\u6839\u9664\u4f9d\u8d56\u4e8e\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u90e8\u5206\u4f9d\u8d56\u4e8e\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176\u3002\u652f\u6301\u8fd9\u4e9b\u53d1\u73b0\u7684\u662f\uff0c\u5728\u5c0f\u9f20\u80bf\u7624\u548c\u63a5\u53d7\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u9ed1\u7d20\u7624\u60a3\u8005\u6d3b\u68c0\u4e2d\u89c2\u5bdf\u5230\u5927\u91cf\u4e2d\u6027\u7c92\u7ec6\u80de\u6d3b\u5316\u3002\u8f6c\u5f55\u7ec4\u548c\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u63ed\u793a\u4e86\u6cbb\u7597\u5c0f\u9f20\u4e2d\u5b58\u5728\u7684\u4e00\u79cd\u5177\u6709\u6297\u80bf\u7624\u4f5c\u7528\u7684\u72ec\u7279\u4e2d\u6027\u7c92\u7ec6\u80de\u4e9a\u7fa4\u3002\u6211\u4eec\u7684\u53d1\u73b0\u63ed\u793a\u4e86\u4e00\u4e2a\u76f8\u4e92\u4f5c\u7528\uff0c\u5373\u4ecb\u5bfc\u521d\u671f\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684T\u7ec6\u80de\u548c\u4ecb\u5bfc\u6297\u539f\u4e22\u5931\u53d8\u5f02\u578b\u80bf\u7624\u6d88\u9664\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CTLA-4\uff1bOX40\uff1b\u8fc7\u7ee7\u6027T\u7ec6\u80de\u7597\u6cd5\uff1b\u6297\u80bf\u7624\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u6297\u539f\u5f02\u8d28\u6027\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff1b\u514d\u75ab\u6cbb\u7597\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\u7ec6\u80de\u5916\u9677\u9631\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u80bf\u7624\u5f02\u8d28\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/strong><\/p>\n<\/section>\n<\/section>\n

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Signal Transduct Target Ther. 20230428<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells<\/strong><\/p>\n

\u901a\u8fc7\u9776\u5411MDSC\u4e2d\u7684GPR84\u6765\u514b\u670d\u514d\u75ab\u7597\u6cd5\u7684\u8010\u836f\u6027<\/strong><\/span><\/p>\n

Signal Transduct Target Ther. 2023 Apr 28;8(1):164.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41392-023-01388-6.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37105980\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5728\u80bf\u7624\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u53d1\u73b0\u9aa8\u9ad3\u6765\u6e90\u7684\u6291\u5236\u6027\u7ec6\u80de\uff08MDSCs\uff09\u5728\u539f\u4f4d\u98df\u7ba1\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\u9010\u6e10\u79ef\u7d2f\u3002\u5c3d\u7ba1\u5df2\u7ecf\u5e7f\u6cdb\u7814\u7a76\u4e86MDSCs\u5728\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u548c\u6291\u5236\u514d\u75ab\u5e94\u7b54\u4e2d\u7684\u4f5c\u7528\uff0c\u4f46\u76ee\u524d\u4ecd\u6ca1\u6709\u9488\u5bf9MDSCs\u7684\u6709\u6548\u4e34\u5e8a\u9776\u5411\u624b\u6bb5\u3002MDSCs\u7279\u5f02\u6027\u6807\u8bb0\u7269\u7f3a\u4e4f\u5bfc\u81f4\u4e34\u5e8a\u6d88\u9664\u7b56\u7565\u53d7\u9650\u3002\u672c\u7814\u7a76\u53d1\u73b0GPR84\u5728MDSCs\u4e0a\u72ec\u6709\u7684\u9ad8\u8868\u8fbe\u3002\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u5728\u4e34\u5e8a\u6837\u672c\u548c\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cGPR84\u5728MDSCs\u4e0a\u8868\u8fbe\u660e\u663e\uff0c\u901a\u8fc7\u6291\u5236\u6eb6\u9176\u4f53\u4e2dPD-L1\u7684\u964d\u89e3\uff0c\u9a71\u52a8\u5bf9CD8+T\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0G-CSF\u548cGM-CSF\u901a\u8fc7STAT3\/C\/EBP\u03b2\u4fe1\u53f7\u901a\u8def\u8bf1\u5bfcGPR84\u8868\u8fbe\u3002\u6b64\u5916\uff0c\u5728\u98df\u7ba1\u764c\u6297PD-1\u6cbb\u7597\u8010\u836f\u60a3\u8005\u4e2d\uff0cGPR84+MDSCs\u548cPD-L1+MDSCs\u9ad8\u5ea6\u79ef\u7d2f\uff0c\u9ad8GPR84\u7279\u5f81\u88ab\u8bc1\u5b9e\u4e3a\u6297PD-1\u6cbb\u7597\u60a3\u8005\u603b\u751f\u5b58\u671f\u7684\u8d1f\u9762\u56e0\u7d20\u3002\u6700\u540e\uff0cGPR84\u62ee\u6297\u5242\u4e0e\u6297PD-1\u6297\u4f53\u7ed3\u5408\uff0c\u589e\u5f3a\u4e86\u6297\u80bf\u7624\u53cd\u5e94\u3002\u9776\u5411GPR84\u589e\u5f3a\u4e86\u98df\u7ba1\u764c\u548c\u5176\u4ed6\u6076\u6027\u80bf\u7624\u4e2d\u6297PD-1\u7684\u7597\u6548\u3002\u8fd9\u79cd\u8054\u5408\u6cbb\u7597\u5728\u4e34\u5e8a\u80bf\u7624\u6cbb\u7597\u4e2d\u5177\u6709\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230329<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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No rest for the wicked: Tumor cell senescence reshapes the immune microenvironment<\/strong><\/p>\n

\u6076\u4eba\u4e0d\u4f11\uff1a\u8870\u8001\u80bf\u7624\u7ec6\u80de\u91cd\u5851\u514d\u75ab\u5fae\u73af\u5883<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Mar 29;S1535-6108(23)00086-7.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.03.013.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37059102\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u8870\u8001\u4f1a\u5f15\u8d77\u5173\u952e\u8868\u578b\u53d8\u5316\uff0c\u4ece\u800c\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u3002Cancer Discovery (PMID: 36302222<\/span>, 36302218<\/span>)\u3001Nature (PMID: 36323784<\/span>) \u548c Nature Cancer (PMID: 36482233<\/span>) \u4e0a\u6700\u8fd1\u7684\u56db\u7bc7\u6587\u7ae0\u5f3a\u8c03\u4e86\u8870\u8001\u7ec6\u80de\uff08\u6b63\u5e38\u8001\u5316\u6216\u5316\u7597\u540e\u7684\u7ec6\u80de\uff09\u5982\u4f55\u8868\u8fbe\u6297\u539f\u5448\u73b0\u673a\u5236\uff0c\u5448\u73b0\u6297\u539f\uff0c\u5e76\u4e0eT\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u5f3a\u70c8\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u5e76\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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08<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230330-2<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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A neutrophil response linked to tumor control in immunotherapy<\/strong><\/p>\n

\u4e2d\u6027\u7c92\u7ec6\u80de\u53cd\u5e94\u53c2\u4e0e\u548c\u514d\u75ab\u6cbb\u7597\u76f8\u5173\u7684\u80bf\u7624\u63a7\u5236<\/strong><\/span><\/p>\n

Cell. 2023 Mar 30;186(7):1448-1464.e20.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.02.032.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37001504\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u4e2d\u6027\u7c92\u7ec6\u80de\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\u79ef\u7d2f\uff0c\u5176\u4e30\u5ea6\u4e0e\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002\u7136\u800c\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u5e76\u975e\u5747\u8d28\uff0c\u53ef\u80fd\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u53d1\u6325\u4e0d\u540c\u7684\u4f5c\u7528\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u7814\u7a76\u4e86\u4e2d\u6027\u7c92\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\uff0c\u5bfc\u81f4\u80bf\u7624\u53d7\u5230\u63a7\u5236\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u6210\u529f\u7684\u6cbb\u7597\u6025\u5267\u6269\u5927\u4e86\u80bf\u7624\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u6570\u91cf\u3002\u8fd9\u79cd\u6269\u5f20\u53ef\u4ee5\u5f52\u56e0\u4e8e\u9ad8Sell\uff08\u57fa\u56e0\u540d\uff09\u72b6\u6001\uff0c\u800c\u4e0d\u662f\u4fc3\u4f7f\u80bf\u7624\u8fdb\u5c55\u7684\u5176\u4ed6\u4e2d\u6027\u7c92\u7ec6\u80de\u3002\u6cbb\u7597\u8bf1\u5bfc\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u83b7\u5f97\u4e86\u5e72\u6270\u7d20\u57fa\u56e0\u7279\u5f81\uff0c\u8fd9\u4e5f\u51fa\u73b0\u5728\u4eba\u7c7b\u60a3\u8005\u8eab\u4e0a\uff0c\u5e76\u4e14\u5bf9\u4e8e\u6210\u529f\u7684\u6cbb\u7597\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2d\u5e72\u6270\u7d20\u5e94\u7b54\u8f6c\u5f55\u56e0\u5b50IRF1\u7684\u4e27\u5931\u5bfc\u81f4\u514d\u75ab\u6cbb\u7597\u5931\u8d25\u3002\u4e2d\u6027\u7c92\u7ec6\u80de\u53cd\u5e94\u4f9d\u8d56\u4e8e\u6297\u80bf\u7624\u514d\u75ab\u7684\u5173\u952e\u7ec4\u4ef6\uff0c\u5305\u62ec\u4f9d\u8d56\u4e8eBATF3\u7684DCs\u3001IL-12\u548cIFN\u03b3\u3002\u6b64\u5916\uff0c\u6211\u4eec\u53d1\u73b0\u6cbb\u7597\u8bf1\u5bfc\u7684\u5168\u8eab\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u53cd\u5e94\u4e0e\u80ba\u764c\u60a3\u8005\u7684\u75be\u75c5\u7ed3\u5c40\u5448\u6b63\u76f8\u5173\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u786e\u7acb\u4e86\u4e2d\u6027\u7c92\u7ec6\u80de\u72b6\u6001\u5728\u6709\u6548\u764c\u75c7\u6cbb\u7597\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

IRF1\uff1bSiglecF\uff1b\u6297CD40\uff1b\u6297PD-1\uff1b\u764c\u75c7\uff1b\u514d\u75ab\u6cbb\u7597\uff1b\u5e72\u6270\u7d20\uff1b\u80ba\u764c\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u5355\u7ec6\u80deRNA-seq\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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09<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Hematol Oncol. 20230413<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Novel strategies for cancer immunotherapy: counter-immunoediting therapy<\/strong><\/p>\n

\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u65b0\u7b56\u7565\uff1a\u9006\u5411\u514d\u75ab\u7f16\u8f91\u7597\u6cd5<\/strong><\/span><\/p>\n

J Hematol Oncol. 2023 Apr 13;16(1):38.<\/em><\/p>\n

doi: <\/strong>10.1186\/s13045-023-01430-8.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37055849\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u514d\u75ab\u7597\u6cd5\u7684\u51fa\u73b0\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7559\u4e0b\u4e86\u4e0d\u53ef\u78e8\u706d\u7684\u5370\u8bb0\uff0c\u7279\u522b\u662f\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u5e94\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3002\u5c3d\u7ba1\u514d\u75ab\u7597\u6cd5\u5728\u4e00\u4e9b\u80bf\u7624\u4e2d\u8bc1\u660e\u4e86\u5176\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u4f46\u8bb8\u591a\u60a3\u8005\u4ecd\u7136\u5bf9\u514d\u75ab\u7597\u6cd5\u5b58\u5728\u5148\u5929\u6027\u6216\u83b7\u5f97\u6027\u8010\u836f\u6027\u3002\u8fd9\u79cd\u73b0\u8c61\u7684\u51fa\u73b0\u4e0e\u80bf\u7624\u7ec6\u80de\u7ecf\u8fc7\u764c\u75c7\u514d\u75ab\u7f16\u8f91\u540e\u5f62\u6210\u7684\u9ad8\u5ea6\u5f02\u8d28\u6027\u514d\u75ab\u5fae\u73af\u5883\u5bc6\u5207\u76f8\u5173\u3002\u764c\u75c7\u514d\u75ab\u7f16\u8f91\u8fc7\u7a0b\u662f\u6307\u80bf\u7624\u7ec6\u80de\u548c\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u5408\u4f5c\u4e92\u52a8\uff0c\u5305\u62ec\u4e09\u4e2a\u9636\u6bb5\uff1a\u6d88\u9664\u3001\u5e73\u8861\u548c\u9003\u9038\u3002\u5728\u8fd9\u4e9b\u9636\u6bb5\uff0c\u514d\u75ab\u7cfb\u7edf\u4e0e\u80bf\u7624\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4ea7\u751f\u4e86\u590d\u6742\u7684\u514d\u75ab\u5fae\u73af\u5883\uff0c\u4ece\u800c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u83b7\u5f97\u4e0d\u540c\u6c34\u5e73\u7684\u514d\u75ab\u6cbb\u7597\u8010\u836f\u6027\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u603b\u7ed3\u4e86\u764c\u75c7\u514d\u75ab\u7f16\u8f91\u7684\u4e0d\u540c\u9636\u6bb5\u7684\u7279\u70b9\u53ca\u76f8\u5e94\u7684\u6cbb\u7597\u5de5\u5177\uff0c\u5e76\u63d0\u51fa\u4e86\u57fa\u4e8e\u514d\u75ab\u8868\u578b\u7684\u89c4\u8303\u5316\u6cbb\u7597\u7b56\u7565\u3002\u901a\u8fc7\u9488\u5bf9\u764c\u75c7\u514d\u75ab\u7f16\u8f91\u4e0d\u540c\u9636\u6bb5\u7684\u9776\u5411\u5e72\u9884\uff0c\u4f7f\u764c\u75c7\u514d\u75ab\u7f16\u8f91\u8fc7\u7a0b\u9006\u8f6c\uff0c\u5728\u7cbe\u786e\u6cbb\u7597\u80cc\u666f\u4e0b\u4f7f\u514d\u75ab\u6cbb\u7597\u6210\u4e3a\u6cbb\u6108\u764c\u75c7\u6700\u6709\u524d\u666f\u7684\u7597\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10<\/strong><\/p>\n<\/section>\n<\/section>\n

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Dev Cell. 20230406<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer<\/strong><\/p>\n

\u4f4d\u4e8e\u5185\u8d28\u7f51\u7684JmjC\u7ed3\u6784\u57df\u86cb\u767dJMJD8\u9776\u5411STING\u4ee5\u4fc3\u8fdb\u4e73\u817a\u764c\u7684\u514d\u75ab\u9003\u9038\u548c\u80bf\u7624\u751f\u957f<\/strong><\/span><\/p>\n

Dev Cell. 2023 Apr 6;S1534-5807(23)00131-4.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.devcel.2023.03.015.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37054705\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5df2\u77e5STING\u4ecb\u5bfc\u7684I\u578b\u5e72\u6270\u7d20\uff08IFN\uff09\u4fe1\u53f7\u901a\u8def\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u8bc1\u660e\u4e86\u4e00\u79cd\u5185\u8d28\u7f51\uff08ER\uff09\u5b9a\u4f4d\u7684JmjC\u7ed3\u6784\u57df\u86cb\u767d\uff0cJMJD8\uff0c\u6291\u5236STING\u8bf1\u5bfc\u7684I\u578bIFN\u53cd\u5e94\uff0c\u4ee5\u4fc3\u8fdb\u514d\u75ab\u9003\u907f\u548c\u4e73\u817a\u80bf\u7624\u53d1\u751f\u3002\u5728\u673a\u5236\u4e0a\uff0cJMJD8\u4e0eTBK1\u7ade\u4e89\u4e0eSTING\u7ed3\u5408\uff0c\u963b\u6b62STING-TBK1\u590d\u5408\u7269\u7684\u5f62\u6210\uff0c\u9650\u5236I\u578bIFN\u548cIFN\u523a\u6fc0\u57fa\u56e0\uff08ISG\uff09\u7684\u8868\u8fbe\u4ee5\u53ca\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u3002JMJD8\u7684\u6572\u4f4e\u63d0\u9ad8\u4e86\u5316\u7597\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\u5728\u6cbb\u7597\u4eba\u7c7b\u548c\u5c0f\u9f20\u4e73\u817a\u764c\u7ec6\u80de\u6765\u6e90\u7684\u79fb\u690d\u7624\u65f6\u7684\u6709\u6548\u6027\u3002\u4e34\u5e8a\u76f8\u5173\u6027\u5728\u4e8eJMJD8\u5728\u4eba\u7c7b\u4e73\u817a\u80bf\u7624\u6837\u672c\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u5176\u8868\u8fbe\u4e0eI\u578bIFN\u548cISGs\u4ee5\u53ca\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u5448\u8d1f\u76f8\u5173\u3002\u603b\u7684\u6765\u8bf4\uff0c\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0JMJD8\u8c03\u8282I\u578bIFN\u53cd\u5e94\uff0c\u9776\u5411JMJD8\u89e6\u53d1\u6297\u80bf\u7624\u514d\u75ab\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

JMJD8\uff1bSTING\uff1b\u6297\u80bf\u7624\u514d\u75ab\uff1b\u4e73\u817a\u764c\uff1bI\u578bIFN\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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11<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Rev Cancer. 20230412<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Dynamics and specificities of T cells in cancer immunotherapy<\/strong><\/p>\n

\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e2dT\u7ec6\u80de\u7684\u52a8\u6001\u548c\u7279\u5f02\u6027<\/strong><\/span><\/p>\n

Nat Rev Cancer. 2023 Apr 12.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41568-023-00560-y.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37046001\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u8fdb\u5c55\uff0c\u4ece\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u5230\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u548c\u75ab\u82d7\uff0c\u5df2\u7ecf\u5f7b\u5e95\u6539\u53d8\u4e86\u80bf\u7624\u6cbb\u7597\u6a21\u5f0f\u3002\u7136\u800c\uff0c\u4e34\u5e8a\u5bf9\u8fd9\u4e9b\u836f\u7269\u53cd\u5e94\u7684\u53d8\u5316\u6fc0\u53d1\u4e86\u4eba\u4eec\u5bf9T\u7ec6\u80de\u5728\u514d\u75ab\u5e72\u9884\u4e0b\u5982\u4f55\u6f14\u53d8\u7684\u6d53\u539a\u5174\u8da3\u3002\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u91cc\uff0c\u591a\u7ef4\u5355\u7ec6\u80de\u6280\u672f\u7684\u51fa\u73b0\u4e3a\u89e3\u6790\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6dcb\u5df4\u7ec6\u80de\u7684\u7ec6\u80de\u72b6\u6001\u63d0\u4f9b\u4e86\u7a7a\u524d\u7684\u80fd\u529b\u3002\u7279\u522b\u662f\uff0c\u901a\u8fc7T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u786e\u5b9a\u80bf\u7624\u5185\u8868\u578b\u4e0eT\u7ec6\u80de\u6297\u539f\u7279\u5f02\u6027\u4e4b\u95f4\u5173\u8054\u7684\u80fd\u529b\u5feb\u901f\u6269\u5c55\uff0c\u4f7f\u5f97\u73b0\u5728\u53ef\u4ee5\u4e13\u6ce8\u4e8e\u7814\u7a76\u5177\u6709\u80bf\u7624\u7279\u5f02\u6027\u53cd\u5e94\u7684T\u7ec6\u80de\u7684\u6027\u8d28\u3002\u6b64\u5916\uff0cTCR\u514b\u9686\u6027\u7684\u8bc4\u4f30\u4f7f\u5f97\u53ef\u4ee5\u91c7\u7528\u5206\u5b50\u65b9\u6cd5\u5728\u514d\u75ab\u6cbb\u7597\u5e72\u9884\u8fc7\u7a0b\u4e2d\u8ffd\u8e2a\u6297\u80bf\u7624T\u7ec6\u80de\u7684\u8f68\u8ff9\u3001\u514b\u9686\u52a8\u6001\u548c\u8868\u578b\u53d8\u5316\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u56de\u987e\u4e86\u6297\u80bf\u7624T\u7ec6\u80de\u7684\u7ec6\u80de\u72b6\u6001\u548c\u6297\u539f\u7279\u5f02\u6027\u7684\u73b0\u6709\u77e5\u8bc6\uff0c\u5e76\u7814\u7a76\u4e86\u5982\u4f55\u901a\u8fc7\u5bf9\u60a3\u8005T\u7ec6\u80de\u52a8\u6001\u7684\u7ec6\u81f4\u5206\u6790\uff0c\u4e3a\u63ed\u793a\u6709\u6548\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u80cc\u540e\u7684\u673a\u5236\u63d0\u4f9b\u6709\u610f\u4e49\u7684\u89c1\u89e3\u3002\u6211\u4eec\u91cd\u70b9\u5173\u6ce8\u4e86\u4e0eT\u7ec6\u80de\u53cd\u5e94\u76f8\u5173\u7684T\u7ec6\u80de\u4e9a\u7fa4\uff0c\u5e76\u8ba8\u8bba\u4e86\u4e0d\u540c\u514d\u75ab\u6cbb\u7597\u5982\u4f55\u5229\u7528\u5df2\u5b58\u5728\u7684\u80bf\u7624\u53cd\u5e94\u6027T\u7ec6\u80de\u5e93\u6216\u5f15\u5bfc\u6297\u80bf\u7624\u7279\u5f02\u6027\u7684\u4ea7\u751f\u3002\u4e0b\u4e00\u6b65\u7684\u7814\u7a76\u5c06\u65e8\u5728\u9610\u660e\u4e0e\u4ea7\u751f\u6709\u6548\u6297\u80bf\u7624T\u7ec6\u80de\u514d\u75ab\u76f8\u5173\u7684\u56e0\u7d20\uff0c\u8fd9\u5c06\u6307\u5bfc\u66f4\u6709\u6548\u7684\u6cbb\u7597\u7b56\u7565\u7684\u8bbe\u8ba1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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12<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230404<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment<\/strong><\/p>\n

\u7624\u5185\u7f57\u4f0a\u6c0f\u4e73\u6746\u83cc\u91ca\u653e\u7684\u81b3\u98df\u8272\u6c28\u9178\u4ee3\u8c22\u7269\u4fc3\u8fdb\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597<\/strong><\/span><\/p>\n

Cell. 2023 Apr 4;S0092-8674(23)00271-4.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.03.011.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37028428\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u75c7\u60a3\u8005\u4f7f\u7528\u76ca\u751f\u83cc\u7684\u60c5\u51b5\u8d8a\u6765\u8d8a\u666e\u904d\uff0c\u5305\u62ec\u90a3\u4e9b\u63a5\u53d7\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u6cbb\u7597\u7684\u60a3\u8005\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u9610\u660e\u4e86\u76ca\u751f\u83cc\u91ca\u653e\u7684\u82b3\u9999\u70c3\u53d7\u4f53\uff08AhR\uff09\u6fc0\u52a8\u5242\u5432\u54da-3-\u919b\uff08I3A\uff09\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684CD8 T\u7ec6\u80de\u4e4b\u95f4\u7684\u5173\u952e\u5fae\u751f\u7269\u5bbf\u4e3b\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u5728\u4e34\u5e8a\u524d\u9ed1\u8272\u7d20\u7624\u4e2d\u5f3a\u70c8\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u5e76\u4fc3\u8fdbICI\u3002\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u76ca\u751f\u83ccLactobacillus reuteri\uff08Lr\uff09\u8fc1\u79fb\u5230\u9ed1\u8272\u7d20\u7624\u4e2d\uff0c\u5b9a\u690d\u5e76\u5728\u5176\u4e2d\u6301\u7eed\u5b58\u5728\uff0c\u901a\u8fc7\u91ca\u653e\u7684\u81b3\u98df\u8272\u6c28\u9178\u4ee3\u8c22\u7269I3A\uff0c\u5728\u5c40\u90e8\u4fc3\u8fdb\u5e72\u6270\u7d20-\u03b3\u4ea7\u751f\u7684CD8 T\u7ec6\u80de\uff0c\u4ece\u800c\u589e\u5f3aICI\u3002\u6b64\u5916\uff0cLr\u5206\u6ccc\u7684I3A\u662f\u9a71\u52a8\u6297\u80bf\u7624\u514d\u75ab\u7684\u5fc5\u8981\u548c\u5145\u5206\u6761\u4ef6\uff0c\u800cCD8 T\u7ec6\u80de\u4e2dAhR\u4fe1\u53f7\u4f20\u5bfc\u7684\u4e27\u5931\u4f1a\u62b5\u6d88Lr\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u5bcc\u542b\u8272\u6c28\u9178\u7684\u996e\u98df\u589e\u5f3a\u4e86Lr\u548cICI\u8bf1\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u8fd9\u53d6\u51b3\u4e8eCD8 T\u7ec6\u80de\u7684AhR\u4fe1\u53f7\u3002\u6700\u540e\uff0c\u6211\u4eec\u4e3aI3A\u5728\u4fc3\u8fdb\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684ICI\u7597\u6548\u548c\u751f\u5b58\u63d0\u4f9b\u4e86\u8bc1\u636e\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u4e73\u9178\u6746\u83cc\uff1b\u82b3\u9999\u70c3\u53d7\u4f53\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff1b\u5432\u54da-3-\u919b\uff1b\u9ed1\u8272\u7d20\u7624\uff1b\u5fae\u751f\u7269AhR\u914d\u4f53\uff1b\u5fae\u751f\u7269-\u5bbf\u4e3b\u76f8\u4e92\u4f5c\u7528\uff1b\u8272\u6c28\u9178\uff1b\u80bf\u7624\u83cc\u7fa4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Small-molecule PIK-93 modulates the tumor microenvironment to improve immune checkpoint blockade response<\/strong><\/p>\n

\u5c0f\u5206\u5b50PIK-93\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u4ee5\u63d0\u9ad8\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u53cd\u5e94<\/strong><\/span><\/p>\n

Sci Adv. 2023 Apr 7;9(14):eade9944.<\/em><\/p>\n

doi: <\/strong>10.1126\/sciadv.ade9944.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37027467\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u9488\u5bf9PD-L1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u514d\u75ab\u6cbb\u7597\u662f\u6cbb\u7597\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u6700\u5148\u8fdb\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u7531\u4e8e\u4e0d\u5229\u7684\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u548c\u57fa\u4e8e\u6297\u4f53\u7684ICI\u6e17\u900f\u6027\u8f83\u5dee\uff0c\u90e8\u5206NSCLC\u60a3\u8005\u7684\u6cbb\u7597\u53cd\u5e94\u4e0d\u5c3d\u5982\u4eba\u610f\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u65e8\u5728\u53d1\u73b0\u53ef\u4ee5\u8c03\u8282TME\u4ee5\u63d0\u9ad8NSCLC\u4f53\u5916\u548c\u4f53\u5185ICI\u6cbb\u7597\u6548\u679c\u7684\u5c0f\u5206\u5b50\u836f\u7269\u3002\u6211\u4eec\u4f7f\u7528\u57fa\u4e8e\u7ec6\u80de\u7684\u5168\u5c40\u86cb\u767d\u8d28\u7a33\u5b9a\u6027\uff08GPS\uff09\u7b5b\u9009\u7cfb\u7edf\uff0c\u9274\u5b9a\u51fa\u4e00\u4e2aPD-L1\u86cb\u767d\u8c03\u8282\u5c0f\u5206\u5b50PIK-93\u3002PIK-93\u901a\u8fc7\u589e\u5f3aPD-L1-Cullin-4A\u76f8\u4e92\u4f5c\u7528\u4fc3\u4f7fPD-L1\u6cdb\u7d20\u5316\u3002PIK-93\u964d\u4f4e\u4e86M1\u5de8\u566c\u7ec6\u80de\u4e0a\u7684PD-L1\u6c34\u5e73\u5e76\u589e\u5f3a\u4e86M1\u6297\u80bf\u7624\u7ec6\u80de\u6bd2\u6027\u3002\u7ed3\u5408PIK-93\u548c\u6297PD-L1\u6297\u4f53\u6cbb\u7597\u589e\u5f3a\u4e86T\u7ec6\u80de\u6fc0\u6d3b\uff0c\u6291\u5236\u4e86\u80bf\u7624\u751f\u957f\uff0c\u5e76\u589e\u52a0\u4e86\u540c\u57fa\u56e0\u548c\u4eba\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de\uff08PBMC\uff09\u7cfb\u884d\u751f\u7684\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u6a21\u578b\u4e2d\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u7684\u62db\u52df\u3002PIK-93\u4e0e\u6297PD-L1\u6297\u4f53\u7ed3\u5408\u65f6\u4fc3\u4f7f\u4e00\u4e2a\u6709\u5229\u4e8e\u6cbb\u7597\u7684TME\uff0c\u4ece\u800c\u589e\u5f3aPD-1\/PD-L1\u963b\u65ad\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14<\/strong><\/p>\n<\/section>\n<\/section>\n

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Trends Biochem Sci. 20230418<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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The metabolic cross-talk between cancer and T cells<\/strong><\/p>\n

\u80bf\u7624\u4e0eT\u7ec6\u80de\u4e4b\u95f4\u7684\u4ee3\u8c22\u76f8\u4e92\u4f5c\u7528<\/strong><\/span><\/p>\n

Trends Biochem Sci. 2023 Apr 18;S0968-0004(23)00080-4.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.tibs.2023.03.004.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37080875\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80bf\u7624\u7ec6\u80de\u4e0eT\u7ec6\u80de\u4e4b\u95f4\u7684\u4ee3\u8c22\u76f8\u4e92\u4f5c\u7528\u51b3\u5b9a\u4e86\u764c\u75c7\u7684\u5f62\u6210\u548c\u8fdb\u5c55\u3002\u8fd9\u4e9b\u7ec6\u80de\u5177\u6709\u4ee3\u8c22\u53ef\u5851\u6027\u3002\u56e0\u6b64\uff0c\u5b83\u4eec\u8c03\u6574\u81ea\u5df1\u7684\u4ee3\u8c22\u7279\u5f81\u4ee5\u6ee1\u8db3\u8868\u578b\u9700\u6c42\u3002\u7136\u800c\uff0c\u80bf\u7624\u7684\u8425\u517b\u5fae\u73af\u5883\u662f\u4e00\u4e2a\u975e\u5e38\u6076\u52a3\u7684\u751f\u6001\u4f4d\uff0c\u8fd9\u4e9b\u7ec6\u80de\u88ab\u8feb\u4e89\u593a\u53ef\u7528\u7684\u8425\u517b\u7269\u8d28\u3002\u80bf\u7624\u7ec6\u80de\u7684\u9ad8\u6d3b\u6027\u4ee3\u8c22\u7ecf\u5e38\u5728\u4fc3\u8fdb\u5177\u6709\u80bf\u7624\u4fc3\u8fdb\u4f5c\u7528\u7684\u8017\u7aedCD8+ T\u7ec6\u80de\u548c\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u540c\u65f6\uff0c\u4e0e\u5177\u6709\u6297\u80bf\u7624\u4f5c\u7528\u7684CD8+ T\u7ec6\u80de\u7ade\u4e89\u3002\u56e0\u6b64\uff0c\u764c\u7ec6\u80de\u9003\u907f\u514d\u75ab\u5e94\u7b54\u5e76\u5931\u53bb\u63a7\u5236\u5730\u6269\u6563\u3002\u8bc6\u522b\u5fc5\u8981\u7684\u4ee3\u8c22\u9014\u5f84\u4ee5\u5c06\u5e73\u8861\u4ece\u80bf\u7624\u4fc3\u8fdb\u578b\u8f6c\u53d8\u4e3a\u6297\u80bf\u7624\u578b\u514d\u75ab\u8868\u578b\u5bf9\u4e8e\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u6297\u80bf\u7624T\u7ec6\u80de\uff1b\u514d\u75ab\u4ee3\u8c22\uff1b\u80bf\u7624\u4fc3\u8fdb\u578bT\u7ec6\u80de\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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15<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20230419<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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PTEN\u7f3a\u5931\u4e73\u817a\u80bf\u7624\u4e2d\u7684PI3K\u03b2\u8c03\u63a7\u514d\u75ab\u9003\u907f<\/strong><\/p>\n

PTEN\u7f3a\u5931\u4e73\u817a\u80bf\u7624\u4e2d\u7684PI3K\u03b2\u8c03\u63a7\u514d\u75ab\u9003\u907f<\/strong><\/span><\/p>\n

Nature. 2023 Apr 19.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-05940-w.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37076617\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

PTEN\u80bf\u7624\u6291\u5236\u57fa\u56e0\u7684\u4e27\u5931\u662f\u6240\u6709\u764c\u75c7\u7c7b\u578b\u4e2d\u6700\u5e38\u89c1\u7684\u81f4\u764c\u9a71\u52a8\u56e0\u7d20\u4e4b\u4e00\u3002PTEN\u662fPI3K\u4fe1\u53f7\u4f20\u5bfc\u7684\u4e3b\u8981\u8d1f\u5411\u8c03\u8282\u5668\u3002\u5df2\u7ecf\u8bc1\u660e\uff0cPI3K\u03b2\u4e9a\u578b\u5728PTEN\u7f3a\u5931\u80bf\u7624\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u4f46PI3K\u03b2\u6d3b\u6027\u7684\u91cd\u8981\u6027\u80cc\u540e\u7684\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u4f7f\u7528\u4e00\u79cd\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b\uff0c\u901a\u8fc7\u6572\u9664Pten\u548cTrp53\uff08\u7f16\u7801p53\uff09\u6765\u7814\u7a76\u4fb5\u88ad\u6027\u4e73\u817a\u764c\uff0c\u53d1\u73b0PI3K\u03b2\u7684\u57fa\u56e0\u5931\u6d3b\u5bfc\u81f4\u4e86\u5f3a\u70c8\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u8fd9\u79cd\u5e94\u7b54\u5728\u514d\u75ab\u529f\u80fd\u6b63\u5e38\u7684\u5c0f\u9f20\u4e2d\u6291\u5236\u4e86\u80bf\u7624\u751f\u957f\uff0c\u4f46\u5728\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u4e2d\u6ca1\u6709\u8fd9\u79cd\u6548\u679c\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cPTEN\u7f3a\u5931\u80cc\u666f\u4e0b\u7684PI3K\u03b2\u5931\u6d3b\u5bfc\u81f4STAT3\u4fe1\u53f7\u51cf\u5f31\uff0c\u5e76\u589e\u52a0\u4e86\u514d\u75ab\u523a\u6fc0\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e86\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u836f\u7269\u5e72\u9884\u7684PI3K\u03b2\u6291\u5236\u4e5f\u8bf1\u53d1\u4e86\u6297\u80bf\u7624\u514d\u75ab\uff0c\u5e76\u4e0e\u514d\u75ab\u6cbb\u7597\u534f\u540c\u4f5c\u7528\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u5728\u8054\u5408\u6cbb\u7597\u4e2d\u5b8c\u5168\u5e94\u7b54\u7684\u5c0f\u9f20\u8868\u73b0\u51fa\u514d\u75ab\u8bb0\u5fc6\uff0c\u5e76\u5728\u518d\u6b21\u63a5\u79cd\u65f6\u6392\u65a5\u80bf\u7624\u3002\u6211\u4eec\u7684\u7814\u7a76\u63ed\u793a\u4e86\u4e00\u4e2a\u8fde\u63a5PTEN\u4e27\u5931\u548cSTAT3\u6fc0\u6d3b\u7684\u5206\u5b50\u673a\u5236\uff0c\u5e76\u8868\u660ePI3K\u03b2\u5728PTEN\u7f3a\u5931\u80bf\u7624\u4e2d\u63a7\u5236\u514d\u75ab\u9003\u907f\uff0c\u4e3a\u5c06PI3K\u03b2\u6291\u5236\u5242\u4e0e\u514d\u75ab\u6cbb\u7597\u76f8\u7ed3\u5408\u6cbb\u7597PTEN\u7f3a\u5931\u4e73\u817a\u764c\u63d0\u4f9b\u4e86\u5408\u7406\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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16<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nucleic Acids Res. 20230418<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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DeepNeo: a webserver for predicting immunogenic neoantigens<\/strong><\/p>\n

DeepNeo\uff1a\u4e00\u4e2a\u7528\u4e8e\u9884\u6d4b\u514d\u75ab\u539f\u6027\u65b0\u6297\u539f\u7684\u5728\u7ebf\u5de5\u5177<\/strong><\/span><\/p>\n

Nucleic Acids Res. 2023 Apr 18;gkad275.<\/em><\/p>\n

doi: <\/strong>10.1093\/nar\/gkad275.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37070174\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u975e\u81ea\u4f53\u8868\u4f4d\uff0c\u65e0\u8bba\u662f\u6765\u6e90\u4e8e\u5916\u6765\u7269\u8d28\u8fd8\u662f\u4f53\u7ec6\u80de\u7a81\u53d8\uff0c\u5728\u88ab\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff08MHC\uff09\u5206\u5b50\u5448\u9012\u5e76\u88abT\u7ec6\u80de\u8bc6\u522b\u65f6\u5f15\u53d1\u514d\u75ab\u5e94\u7b54\u3002\u9274\u5b9a\u5177\u6709\u514d\u75ab\u6d3b\u6027\u7684\u65b0\u8868\u4f4d\u5728\u764c\u75c7\u548c\u75c5\u6bd2\u533b\u5b66\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u7136\u800c\uff0c\u76ee\u524d\u7684\u65b9\u6cd5\u4e3b\u8981\u5c40\u9650\u4e8e\u9884\u6d4b\u7a81\u53d8\u80bd\u4e0eMHC\u7684\u7269\u7406\u7ed3\u5408\u3002\u6211\u4eec\u4e4b\u524d\u5f00\u53d1\u4e86\u4e00\u4e2a\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u6a21\u578bDeepNeo\uff0c\u901a\u8fc7\u6355\u83b7\u5177\u6709T\u7ec6\u80de\u53cd\u5e94\u6027\u7684\u80bd-MHC\u914d\u5bf9\u7684\u7ed3\u6784\u7279\u6027\u6765\u8bc6\u522b\u514d\u75ab\u539f\u6027\u65b0\u8868\u4f4d\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u4f7f\u7528\u6700\u65b0\u7684\u8bad\u7ec3\u6570\u636e\u5347\u7ea7\u4e86\u6211\u4eec\u7684DeepNeo\u6a21\u578b\u3002\u5347\u7ea7\u540e\u7684\u6a21\u578b\uff08DeepNeo-v2\uff09\u5728\u8bc4\u4f30\u6307\u6807\u4e0a\u5f97\u5230\u4e86\u6539\u8fdb\uff0c\u5e76\u5c55\u793a\u4e86\u66f4\u7b26\u5408\u5df2\u77e5\u65b0\u6297\u539f\u884c\u4e3a\u7684\u9884\u6d4b\u5f97\u5206\u5206\u5e03\u3002\u514d\u75ab\u539f\u6027\u65b0\u6297\u539f\u9884\u6d4b\u53ef\u4ee5\u5728https:\/\/deepneo.net\u4e0a\u8fdb\u884c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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17<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Hematol Oncol. 20230417<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Emerging evidence and treatment paradigm of non-small cell lung cancer<\/strong><\/p>\n

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J Hematol Oncol. 2023 Apr 17;16(1):40.<\/em><\/p>\n

doi: <\/strong>10.1186\/s13045-023-01436-2.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37069698\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u751f\u7269\u6807\u5fd7\u7269\u9a71\u52a8\u7597\u6cd5\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7814\u7a76\u6b63\u5728\u8fc5\u901f\u53d1\u5c55\u3002\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5e7f\u5ea6\u548c\u6df1\u5ea6\u4e5f\u4ee5\u524d\u6240\u672a\u6709\u7684\u901f\u5ea6\u663e\u8457\u63d0\u9ad8\u3002\u4e2a\u6027\u5316\u6cbb\u7597\u8303\u5f0f\u6bcf\u5e74\u90fd\u5728\u4e0d\u65ad\u6f14\u53d8\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u603b\u7ed3\u4e86\u6539\u53d8\u4e86\u6240\u6709\u9636\u6bb5NSCLC\u60a3\u8005\u6cbb\u7597\u8303\u5f0f\u7684\u6709\u524d\u666f\u7684\u836f\u7269\uff0c\u5305\u62ec\u9776\u5411\u6cbb\u7597\u548c\u4f7f\u7528\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u514d\u75ab\u6cbb\u7597\u3002\u6839\u636e\u6700\u8fd1\u7684\u8bc1\u636e\uff0c\u6211\u4eec\u4e3aNSCLC\u63d0\u51fa\u6cbb\u7597\u7b97\u6cd5\uff0c\u5e76\u63d0\u51fa\u4e86\u4e00\u4e9b\u5c1a\u672a\u89e3\u51b3\u7684\u4e34\u5e8a\u95ee\u9898\uff0c\u8fd9\u4e9b\u95ee\u9898\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u63a2\u8ba8\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u7684\u7ed3\u679c\u53ef\u80fd\u4f1a\u5f71\u54cd\u672a\u6765\u7684\u4e34\u5e8a\u5b9e\u8df5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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18<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230413-1<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Advances in cancer immunotherapies<\/strong><\/p>\n

\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u8fdb\u5c55<\/strong><\/span><\/p>\n

Cell. 2023 Apr 13;186(8):1814-1814.e1.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.02.039.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37059073\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u4fc3\u4f7f\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u548c\u6d88\u9664\u764c\u7ec6\u80de\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u5373\u764c\u75c7\u514d\u75ab\u6cbb\u7597\uff0c\u5df2\u7ecf\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u4e00\u4e2a\u72ec\u7279\u652f\u67f1\u3002\u5176\u4e2d\u6700\u5177\u524d\u666f\u7684\u6cbb\u7597\u65b9\u6cd5\u5305\u62ec\u6cbb\u7597\u6027\u75ab\u82d7\u3001\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u3001\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u8bf1\u5bfc\u5242\uff08BiTEs\uff09\u548c\u8fc7\u7ee7\u6027\u7ec6\u80de\u6cbb\u7597\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5177\u6709\u5171\u540c\u7684\u4f5c\u7528\u673a\u5236\uff0c\u5373\u8bf1\u5bfc\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684T\u7ec6\u80de\u4e3a\u57fa\u7840\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u65e0\u8bba\u662f\u5185\u6e90\u6027\u8fd8\u662f\u5de5\u7a0b\u6027\uff0c\u4f46\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\uff08\u5c24\u5176\u662f\u6297\u539f\u5448\u73b0\u7ec6\u80de\uff09\u4e0e\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4e5f\u662f\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6709\u6548\u6027\u7684\u57fa\u7840\uff0c\u76ee\u524d\u8fd8\u5728\u5f00\u53d1\u4e0e\u8fd9\u4e9b\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u65b9\u6cd5\u3002\u8981\u67e5\u770b\u6b64SnapShot\uff0c\u8bf7\u6253\u5f00\u6216\u4e0b\u8f7dPDF\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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19<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230413-2<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Cancer neuroscience: State of the field, emerging directions<\/strong><\/p>\n

\u764c\u75c7\u795e\u7ecf\u79d1\u5b66\uff1a\u73b0\u72b6\u4e0e\u65b0\u5174\u65b9\u5411<\/strong><\/span><\/p>\n

Cell. 2023 Apr 13;186(8):1689-1707.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.02.002<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37059069\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u795e\u7ecf\u7cfb\u7edf\u65e2\u4e3b\u5bfc\u4e2a\u4f53\u53d1\u80b2\uff0c\u4e5f\u8c03\u63a7\u80bf\u7624\u5f62\u6210\u3002\u795e\u7ecf\u7cfb\u7edf\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u8c03\u8282\u5668\u5b98\u53d1\u751f\uff0c\u7ef4\u6301\u4f53\u5185\u7a33\u6001\uff0c\u5e76\u5728\u6574\u4e2a\u751f\u547d\u8fc7\u7a0b\u4e2d\u4fc3\u8fdb\u53ef\u5851\u6027\uff0c\u4e0e\u6b64\u540c\u65f6\u5728\u764c\u75c7\u8c03\u63a7\u4e2d\u53d1\u6325\u7c7b\u4f3c\u4f5c\u7528\u3002\u57fa\u7840\u7814\u7a76\u53d1\u73b0\uff0c\u795e\u7ecf\u5143\u4e0e\u764c\u7ec6\u80de\u4e4b\u95f4\u5b58\u5728\u76f4\u63a5\u7684\u65c1\u5206\u6ccc\u548c\u7535\u5316\u5b66\u901a\u4fe1\uff0c\u800c\u5728\u5e7f\u6cdb\u7684\u6076\u6027\u80bf\u7624\u4e2d\uff0c\u795e\u7ecf\u7cfb\u7edf\u5bf9\u514d\u75ab\u7cfb\u7edf\u548c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u57fa\u8d28\u7ec6\u80de\u7684\u5f71\u54cd\u4e5f\u5b58\u5728\u95f4\u63a5\u76f8\u4e92\u4f5c\u7528\u3002\u795e\u7ecf\u7cfb\u7edf\u4e0e\u764c\u75c7\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u53ef\u8c03\u8282\u764c\u75c7\u53d1\u751f\u3001\u751f\u957f\u3001\u4fb5\u88ad\u548c\u8f6c\u79fb\u3001\u6cbb\u7597\u8010\u53d7\u6027\u3001\u523a\u6fc0\u4fc3\u80bf\u7624\u708e\u75c7\u7684\u53d1\u751f\u4ee5\u53ca\u635f\u5bb3\u6297\u764c\u514d\u75ab\u3002\u764c\u75c7\u795e\u7ecf\u79d1\u5b66\u7684\u8fdb\u5c55\u53ef\u80fd\u4e3a\u764c\u75c7\u6cbb\u7597\u521b\u9020\u4e00\u4e2a\u91cd\u8981\u7684\u65b0\u652f\u67f1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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20<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230413-3<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Immune checkpoint therapy-current perspectives and future directions<\/strong><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\uff1a\u5f53\u524d\u89c2\u70b9\u548c\u672a\u6765\u65b9\u5411<\/strong><\/span><\/p>\n

Cell. 2023 Apr 13;186(8):1652-1669.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.03.006.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37059068\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\uff08ICT\uff09\u5df2\u6781\u5927\u5730\u6539\u5584\u4e86\u764c\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u7ed3\u5c40\uff0c\u4e3a\u90e8\u5206\u60a3\u8005\u5e26\u6765\u4e86\u6301\u4e45\u7684\u4e34\u5e8a\u76ca\u5904\uff0c\u751a\u81f3\u6cbb\u6108\u3002\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u7684\u53cd\u5e94\u7387\u5dee\u5f02\u4ee5\u53ca\u4f18\u5316\u60a3\u8005\u7b5b\u9009\u7684\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u9700\u6c42\u4ee5\u6700\u5927\u5316\u7597\u6548\u548c\u6700\u5c0f\u5316\u6bd2\u6027\uff0c\u4fc3\u4f7f\u4eba\u4eec\u52aa\u529b\u7814\u7a76\u8c03\u8282ICT\u53cd\u5e94\u7684\u514d\u75ab\u548c\u975e\u514d\u75ab\u56e0\u7d20\u3002\u672c\u7efc\u8ff0\u91cd\u70b9\u4ecb\u7ecd\u4e86\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u53ca\u5176\u5728ICT\u4e2d\u7684\u5e94\u7b54\u548c\u8010\u836f\u6027\u80cc\u540e\u7684\u751f\u7269\u5b66\u539f\u7406\uff0c\u8ba8\u8bba\u4e86\u89e3\u51b3ICT\u5f53\u524d\u6311\u6218\u7684\u52aa\u529b\uff0c\u5e76\u6982\u8ff0\u4e86\u6307\u5bfcICT\u540e\u7eed\u4e34\u5e8a\u8bd5\u9a8c\u548c\u8054\u5408\u6cbb\u7597\u7b56\u7565\u7684\u65b9\u5411\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CTLA-4\uff1bICT\uff1bPD-1\uff1bPD-L1\uff1b\u8054\u5408\u751f\u7269\u6807\u5fd7\u7269\uff1b\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u86cb\u767d4\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\uff1b\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff1birAEs\uff1b\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d1\uff1b\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff1b\u9006\u5411\u7ffb\u8bd1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u516c\u4f17\u53f7\u53d1\u9001202304\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/section>\n
\u7b5b\u9009\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n


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SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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