{"id":5091,"date":"2023-06-24T22:03:54","date_gmt":"2023-06-24T14:03:54","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/06\/24\/monthly-updates-2023-05\/"},"modified":"2025-01-03T18:49:39","modified_gmt":"2025-01-03T10:49:39","slug":"monthly-updates-2023-05","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/06\/24\/monthly-updates-2023-05\/","title":{"rendered":"Monthly Updates 2023.05"},"content":{"rendered":"
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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Res. 20230504<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches<\/strong><\/p>\n

SCUBE2\u901a\u8fc7\u8c03\u8282\u514d\u75ab\u6291\u5236\u6027\u6210\u9aa8\u7ec6\u80de\u4ecb\u5bfc\u4e73\u817a\u764c\u7684\u9aa8\u8f6c\u79fb<\/strong><\/span><\/p>\n

Cell Res. 2023 May 4.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41422-023-00810-6.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37142671\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u96cc\u6fc0\u7d20\u53d7\u4f53\uff08ER\uff09\u9633\u6027\u4e73\u817a\u764c\u662f\u4e00\u79cd\u5177\u6709\u8f83\u4f4e\u8fdc\u5904\u5668\u5b98\u8f6c\u79fb\u98ce\u9669\u7684\u4e9a\u578b\u3002\u7136\u800c\uff0c\u9aa8\u590d\u53d1\u5728\u4e73\u817a\u764c\u4e2d\u66f4\u5bb9\u6613\u53d1\u751f\u3002\u8fd9\u79cd\u4e9a\u578b\u7279\u5f02\u6027\u7684\u5668\u5b98\u7279\u5f02\u6027\u673a\u5236\u4ecd\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5c55\u793a\u4e86\u4e00\u4e2aER\u8c03\u63a7\u7684\u5206\u6ccc\u86cb\u767dSCUBE2\u6709\u52a9\u4e8e\u4e73\u817a\u764c\u7684\u9aa8\u8f6c\u79fb\u3002\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u5206\u6790\u63ed\u793a\u4e86\u65e9\u671f\u9aa8\u8f6c\u79fb\u5fae\u73af\u5883\u4e2dSCUBE2\u4fc3\u4f7f\u6210\u9aa8\u7ec6\u80de\u7684\u5bcc\u96c6\u3002SCUBE2\u4fc3\u4f7f\u80bf\u7624\u819c\u951a\u5b9a\u7684SHH\u91ca\u653e\uff0c\u4ee5\u6fc0\u6d3b\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e2d\u7684Hedgehog\u4fe1\u53f7\u901a\u8def\uff0c\u4ece\u800c\u4fc3\u8fdb\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u3002\u6210\u9aa8\u7ec6\u80de\u6c89\u79ef\u80f6\u539f\u86cb\u767d\u901a\u8fc7\u6291\u5236LAIR1\u4fe1\u53f7\u6291\u5236NK\u7ec6\u80de\uff0c\u4fc3\u8fdb\u80bf\u7624\u5b9a\u690d\u3002SCUBE2\u7684\u8868\u8fbe\u548c\u5206\u6ccc\u4e0e\u4eba\u7c7b\u80bf\u7624\u7684\u6210\u9aa8\u7ec6\u80de\u5206\u5316\u548c\u9aa8\u8f6c\u79fb\u76f8\u5173\u3002\u9776\u5411Hedgehog\u4fe1\u53f7\u901a\u8def\u7684Sonidegib\u548c\u9776\u5411SCUBE2\u7684\u4e2d\u548c\u6297\u4f53\u5747\u53ef\u5728\u591a\u79cd\u8f6c\u79fb\u6a21\u578b\u4e2d\u6709\u6548\u6291\u5236\u9aa8\u8f6c\u79fb\u3002\u603b\u4e4b\uff0c\u6211\u4eec\u7684\u53d1\u73b0\u4e3a\u4e73\u817a\u764c\u8f6c\u79fb\u4e2d\u7684\u9aa8\u504f\u597d\u63d0\u4f9b\u4e86\u673a\u5236\u6027\u89e3\u91ca\uff0c\u5e76\u63d0\u4f9b\u4e86\u65b0\u7684\u8f6c\u79fb\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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02<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Transl Med. 20230503<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer<\/strong><\/p>\n

\u6cbb\u7597\u6027\u963b\u65adVEGF\u4e0eNRP2\u7684\u7ed3\u5408\u901a\u8fc7\u964d\u4f4ePD-L1\u8868\u8fbe\u6fc0\u6d3b\u524d\u5217\u817a\u764c\u4e2d\u7684\u6297\u80bf\u7624\u514d\u75ab<\/strong><\/span><\/p>\n

Sci Transl Med. 2023 May 3; 15 (694) : eade5855.<\/em><\/p>\n

doi: <\/strong>10.1126\/scitranslmed.ade5855.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37134151\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u524d\u5217\u817a\u764c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09\u7684\u53cd\u5e94\u8f83\u5dee\uff0c\u4e14\u6709\u5145\u5206\u8bc1\u636e\u8868\u660e\uff0c\u5fc5\u987b\u6291\u5236\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f53-1\uff08PD-L1\uff09\u7684\u8868\u8fbe\u4ee5\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u53d1\u73b0\u795e\u7ecf\u7ea4\u6bdb\u86cb\u767d2\uff08NRP2\uff09\uff0c\u4f5c\u4e3a\u80bf\u7624\u7ec6\u80de\u4e0a\u7684\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u53d7\u4f53\uff0c\u662f\u6fc0\u6d3b\u524d\u5217\u817a\u764c\u6297\u80bf\u7624\u514d\u75ab\u7684\u4e00\u4e2a\u6709\u5438\u5f15\u529b\u7684\u9776\u6807\uff0c\u56e0\u4e3aVEGF-NRP2\u4fe1\u53f7\u662f\u7ef4\u6301PD-L1\u8868\u8fbe\u7684\u91cd\u8981\u56e0\u7d20\u3002NRP2\u8017\u7aed\u589e\u52a0\u4e86\u4f53\u5916T\u7ec6\u80de\u6fc0\u6d3b\u3002\u5728\u5bf9ICI\u8010\u836f\u7684\u524d\u5217\u817a\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u4f7f\u7528\u5c0f\u9f20\u7279\u5f02\u6027\u7684\u6297NRP2\u5355\u514b\u9686\u6297\u4f53\uff08mAb\uff09\u6291\u5236VEGF\u4e0eNRP2\u7684\u7ed3\u5408\uff0c\u4e0e\u6297PD-L1 mAb\u548c\u5bf9\u7167\u514d\u75ab\u7403\u86cb\u767dG\u76f8\u6bd4\uff0c\u5bfc\u81f4\u4e86\u80bf\u7624\u7684\u574f\u6b7b\u548c\u6d88\u9000\u3002\u8fd9\u79cd\u7597\u6cd5\u8fd8\u964d\u4f4e\u4e86\u80bf\u7624PD-L1\u8868\u8fbe\uff0c\u589e\u52a0\u4e86\u6d78\u6da6\u6027CD8+ T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u5e76\u8bf1\u5bfc\u4e86IFN-\u03b3\u4ea7\u751f\u3002\u6211\u4eec\u8bc1\u660e\u4e86\u4e00\u79cd\u65b0\u578b\u6297NRP2 mAb\uff08MABN217\uff09\u53ef\u4ee5\u963b\u65ad\u4eba\u7c7bVEGF\u4e0eNRP2\u7684\u7ed3\u5408\uff0c\u5e76\u5728\u591a\u79cd\u524d\u5217\u817a\u764c\u7ec6\u80de\u7cfb\u4e2d\u6291\u5236VEGF\u8bf1\u5bfc\u7684PD-L1\u8868\u8fbe\u3002\u5728\u5bf9\u6297PD-1\u6cbb\u7597\u8010\u836f\u7684\u524d\u5217\u817a\u764c\u60a3\u8005\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u4e2d\uff0cMABN217\u4e5f\u53ef\u4ee5\u6062\u590dT\u7ec6\u80de\u6d3b\u6027\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u6570\u636e\u652f\u6301\u5728\u524d\u5217\u817a\u764c\u4e2d\u4f7f\u7528\u6297NRP2\u7597\u6cd5\u4ee5\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Host Microbe. 20230427<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer<\/strong><\/p>\n

Fusobacterium\u6746\u83cc\u6765\u6e90\u7684\u7425\u73c0\u9178\u8bf1\u5bfc\u4e86\u7ed3\u76f4\u80a0\u764c\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u8010\u836f\u6027<\/strong><\/p>\n

Cell Host Microbe. 2023 Apr 27;S1931-3128(23)00161-0.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.chom.2023.04.010.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37130518\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u4f7f\u7528\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\uff08mAb\uff09\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u662f\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u4e00\u79cd\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u4e00\u4e9b\u60a3\u8005\u5bf9PD-1\u963b\u65ad\u6cbb\u7597\u4ecd\u7136\u6ca1\u6709\u53cd\u5e94\u3002\u80a0\u9053\u83cc\u7fa4\u5df2\u88ab\u8ba4\u4e3a\u4e0e\u514d\u75ab\u6cbb\u7597\u8010\u836f\u6027\u6709\u5173\uff0c\u4f46\u5176\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u5bf9\u514d\u75ab\u6cbb\u7597\u65e0\u53cd\u5e94\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5177\u6709\u66f4\u591a\u7684Fusobacterium\u6746\u83cc\u548c\u7425\u73c0\u9178\u3002\u6765\u81ea\u4f4eF. \u6746\u83cc\u53cd\u5e94\u8005\u7684\u7caa\u4fbf\u83cc\u7fa4\u8f6c\u79fb\u53ef\u4f7f\u5c0f\u9f20\u5bf9\u6297PD-1 mAb\u654f\u611f\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cF. \u6746\u83cc\u6765\u6e90\u7684\u7425\u73c0\u9178\u6291\u5236\u4e86cGAS-\u5e72\u6270\u7d20-\u03b2\u9014\u5f84\uff0c\u4ece\u800c\u901a\u8fc7\u9650\u5236CD8+ T\u7ec6\u80de\u5728\u4f53\u5185\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684\u8fc1\u79fb\u6765\u51cf\u5f31\u6297\u80bf\u7624\u53cd\u5e94\u3002\u7528\u6297\u751f\u7d20\u7532\u785d\u5511\u5904\u7406\u53ef\u964d\u4f4e\u80a0\u9053F. nucleatum\u4e30\u5ea6\uff0c\u4ece\u800c\u964d\u4f4e\u8840\u6e05\u7425\u73c0\u9178\u6c34\u5e73\uff0c\u5e76\u91cd\u65b0\u4f7f\u80bf\u7624\u5bf9\u4f53\u5185\u514d\u75ab\u6cbb\u7597\u654f\u611f\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0cF. \u6746\u83cc\u548c\u7425\u73c0\u9178\u8bf1\u5bfc\u4e86\u80bf\u7624\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u8010\u836f\u6027\uff0c\u4e3aCRC\u4e2d\u7684\u83cc\u7fa4-\u4ee3\u8c22\u7269-\u514d\u75ab\u7684\u76f8\u4e92\u4f5c\u7528\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

Fusobacterium\u6746\u83cc\uff1bcGAS-IFN-\u03b2\u9014\u5f84\uff1b\u7ed3\u76f4\u80a0\u764c\uff1b\u514d\u75ab\u6cbb\u7597\uff1b\u7425\u73c0\u9178\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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04<\/strong><\/p>\n<\/section>\n<\/section>\n

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Trends Cancer. 20230426<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Immune mechanisms of toxicity from checkpoint inhibitors<\/strong><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4ea7\u751f\u6bd2\u6027\u7684\u514d\u75ab\u673a\u5236<\/strong><\/span><\/p>\n

Trends Cancer. 2023 Apr 26;S2405-8033(23)00058-4.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.trecan.2023.04.002.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37117135\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u91cc\uff0c\u514d\u75ab\u6cbb\u7597\u6539\u53d8\u4e86\u764c\u75c7\u6cbb\u7597\u7684\u683c\u5c40\u3002\u6291\u5236\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767d\u5982CTLA-4\u3001PD-1\u548cPD-L1\u7684\u6291\u5236\u5242\u80fd\u591f\u5728\u4e00\u90e8\u5206\u8f6c\u79fb\u6027\u75be\u75c5\u60a3\u8005\u4e2d\u8bf1\u5bfc\u6301\u4e45\u7f13\u89e3\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u6cbb\u7597\u53ef\u80fd\u53d7\u5230\u5f71\u54cd\u5668\u5b98\u7cfb\u7edf\u7684\u708e\u75c7\u6027\u6bd2\u6027\u7684\u9650\u5236\uff0c\u67d0\u4e9b\u60c5\u51b5\u4e0b\u751a\u81f3\u53ef\u80fd\u5371\u53ca\u751f\u547d\u3002\u5728\u7406\u89e3\u8fd9\u4e9b\u6bd2\u6027\u7684\u9a71\u52a8\u56e0\u7d20\u4ee5\u53ca\u6709\u6548\u7ba1\u7406\u7b56\u7565\u65b9\u9762\u5df2\u53d6\u5f97\u4e86\u76f8\u5f53\u5927\u7684\u8fdb\u5c55\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u9a71\u52a8\u6bd2\u6027\u7684\u5206\u5b50\u548c\u7ec6\u80de\u673a\u5236\u5c06\u6709\u52a9\u4e8e\u66f4\u597d\u5730\u9884\u6d4b\u6bd2\u6027\u5e76\u5f00\u53d1\u4f18\u5316\u6cbb\u7597\u7b56\u7565\uff0c\u907f\u514d\u5e72\u6270\u6297\u80bf\u7624\u514d\u75ab\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u76ee\u524d\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u708e\u75c7\u6027\u6bd2\u6027\u7684\u8ba4\u8bc6\uff0c\u5e76\u63d0\u51fa\u4e86\u9488\u5bf9\u8fd9\u4e9b\u6bd2\u6027\u7684\u6700\u4f73\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u764c\u75c7\u514d\u75ab\u6cbb\u7597\uff1b\u68c0\u67e5\u70b9\u963b\u65ad\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff1b\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff1b\u708e\u75c7\u6027\u6bd2\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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05<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gastroenterology. 20230530<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Spatially resolved multi-omics single-cell analyses inform mechanisms of immune-dysfunction in pancreatic cancer<\/strong><\/p>\n

\u80f0\u817a\u764c\u514d\u75ab\u529f\u80fd\u969c\u788d\u673a\u5236\u7684\u7a7a\u95f4\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u89e3\u6790<\/strong><\/span><\/p>\n

Gastroenterology. 2023 May 30;S0016-5085(23)00810-7.<\/em><\/p>\n

doi: <\/strong>10.1053\/j.gastro.2023.05.036.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37263303\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80cc\u666f\u4e0e\u76ee\u7684\uff1a<\/strong>\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u662f\u4e00\u79cd\u6cbb\u7597\u96be\u5ea6\u6781\u5927\u7684\u6076\u6027\u80bf\u7624\uff0c\u5c3d\u7ba1\u5728\u5176\u4ed6\u5b9e\u4f53\u6076\u6027\u80bf\u7624\u4e2d\u514d\u75ab\u6cbb\u7597\u6548\u679c\u826f\u597d\uff0c\u4f46\u5bf9PDAC\u7684\u6cbb\u7597\u5e72\u9884\u4ecd\u7136\u56f0\u96be\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u8feb\u5207\u9700\u8981\u66f4\u6df1\u5165\u4e86\u89e3PDAC\u7684\u514d\u75ab\u5fae\u73af\u5883\u3002\u672c\u7814\u7a76\u65e8\u5728\u4f7f\u7528\u7a7a\u95f4\u89e3\u6790\u7684\u591a\u6a21\u6001\u5355\u7ec6\u80de\u65b9\u6cd5\uff0c\u63ed\u793aPDAC\u514d\u75ab\u5fae\u73af\u5883\u7684\u8be6\u7ec6\u89c6\u56fe\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/strong>\u6211\u4eec\u4f7f\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u3001\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u3001\u591a\u91cd\u514d\u75ab\u7ec4\u5316\u548c\u8d28\u8c31\u7ec6\u80de\u672f\uff0c\u5bf9\u672a\u7ecf\u6cbb\u7597\u7684PDAC\u80bf\u7624\u53ca\u5176\u76f8\u90bb\u6b63\u5e38\u80f0\u817a\u7ec4\u7ec7\u4e2d\u7684\u514d\u75ab\u6210\u5206\uff0c\u4ee5\u53ca\u7cfb\u7edf\u5faa\u73af\u4e2d\u7684\u514d\u75ab\u6210\u5206\u8fdb\u884c\u5206\u6790\u3002\u6211\u4eec\u786e\u5b9a\u4e86\u514d\u75ab\u7279\u5f81\u4e0e\u9884\u540e\u7684\u5173\u8054\uff0c\u5e76\u5bf9PDAC\u548c\u80ba\u817a\u764c\uff08LUAD\uff09\u7684\u514d\u75ab\u5fae\u73af\u5883\u8fdb\u884c\u4e86\u5355\u7ec6\u80de\u6c34\u5e73\u7684\u6c47\u603b\u5206\u6790\u3002<\/p>\n

\u7ed3\u679c\uff1a<\/strong>\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u7a7a\u95f4\u89e3\u6790\u7684\u7cbe\u7ec6\u5730\u56fe\uff0c\u5c55\u793a\u4e86PDAC\u7684\u514d\u75ab\u666f\u89c2\u3002\u6211\u4eec\u8bc1\u5b9e\u4e86CD8 T\u7ec6\u80de\u7684\u8017\u7aed\u8868\u578b\u548c\u9ad3\u6837\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u7279\u5f81\uff0c\u5e76\u7a81\u663e\u51fa\u5728PDAC\u4e2d\u53ef\u80fd\u88ab\u4f4e\u4f30\u7684\u514d\u75ab\u4e9a\u7fa4\u3002\u8fd9\u4e9b\u4e9a\u7fa4\u4e0e\u76f8\u90bb\u6b63\u5e38\u533a\u57df\u5185\u7684\u514d\u75ab\u7ec6\u80de\u7fa4\u6709\u6240\u4e0d\u540c\uff0c\u7279\u522b\u662fCD4 T\u7ec6\u80de\u4e9a\u7fa4\u548cNKT\u7ec6\u80de\uff0c\u5b83\u4eec\u5904\u4e8e\u7ec8\u672b\u8017\u7aed\u72b6\u6001\u5e76\u5177\u6709\u8c03\u8282\u8868\u578b\u3002\u6211\u4eec\u8fd8\u53d1\u73b0\uff0cPDAC\u548cLUAD\u7684\u514d\u75ab\u8868\u578b\u5b58\u5728\u5dee\u5f02\uff0cPDAC\u4e2d\u5b58\u5728\u6781\u5ea6\u514d\u75ab\u6291\u5236\u7684\u4e9a\u578b\uff0c\u4ee5\u53ca\u72ec\u7279\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u7ec4\u6210\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/strong>\u6211\u4eec\u7684\u7814\u7a76\u63ed\u793a\u4e86PDAC\u4e2d\u591a\u5c42\u6b21\u7684\u514d\u75ab\u529f\u80fd\u969c\u788d\uff0c\u5e76\u5448\u73b0\u4e86PDAC\u548cLUAD\u514d\u75ab\u666f\u89c2\u7684\u6574\u4f53\u89c6\u56fe\u3002\u8fd9\u4e3a\u529f\u80fd\u7814\u7a76\u548cPDAC\u4e2d\u5177\u6709\u6cbb\u7597\u6f5c\u529b\u7684\u9776\u70b9\u63a2\u7d22\u63d0\u4f9b\u4e86\u5168\u9762\u7684\u8d44\u6e90\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u80ba\u764c\uff1b\u80f0\u817a\u764c\uff1b\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\uff1b\u80bf\u7624\u514d\u75ab\u5b66\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Commun. 20230510<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer<\/strong><\/p>\n

\u7a7a\u95f4\u591a\u7ec4\u5b66\u89e3\u6790\u80c3\u764c\u4e2d\u7279\u5f02\u6027\u7ec6\u80de\u4ee3\u8c22\u91cd\u5851\u53ca\u76f8\u4e92\u4f5c\u7528<\/strong><\/span><\/p>\n

Nat Commun. 2023 May 10;14(1):2692.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-023-38360-5.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37164975\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u63cf\u7ed8\u80bf\u7624\u4ee3\u8c22\u91cd\u5851\u53ca\u5176\u4e0e\u5468\u56f4\u975e\u80bf\u7624\u7ec6\u80de\u7684\u7a7a\u95f4\u4ea4\u6d41\u53ef\u4ee5\u4ece\u6839\u672c\u4e0a\u63d0\u9ad8\u6211\u4eec\u5bf9\u80bf\u7624\u751f\u7269\u5b66\u7684\u7406\u89e3\uff0c\u4fc3\u8fdb\u5148\u8fdb\u6cbb\u7597\u7b56\u7565\u7684\u8bbe\u8ba1\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u63d0\u51fa\u4e86\u4e00\u79cd\u5c06\u8d28\u8c31\u6210\u50cf\u4e3a\u57fa\u7840\u7684\u7a7a\u95f4\u4ee3\u8c22\u7ec4\u5b66\u548c\u8102\u8d28\u7ec4\u5b66\u4e0e\u57fa\u4e8e\u5fae\u9635\u5217\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u76f8\u7ed3\u5408\u7684\u65b9\u6cd5\uff0c\u4ee5\u5c42\u6b21\u5316\u5730\u53ef\u89c6\u5316\u80c3\u764c\u6837\u672c\u4e2d\u7684\u80bf\u7624\u5185\u4ee3\u8c22\u5f02\u8d28\u6027\u548c\u7ec6\u80de\u4ee3\u8c22\u76f8\u4e92\u4f5c\u7528\u3002\u80bf\u7624\u76f8\u5173\u7684\u4ee3\u8c22\u91cd\u7f16\u7a0b\u5728\u4ee3\u8c22-\u8f6c\u5f55\u6c34\u5e73\u4e0a\u88ab\u6210\u50cf\uff0c\u4ee3\u8c22\u7269\u3001\u8102\u8d28\u3001\u57fa\u56e0\u5728\u4ee3\u8c22\u9014\u5f84\u4e2d\u88ab\u8fde\u63a5\u5e76\u5728\u5f02\u8d28\u6027\u764c\u7ec4\u7ec7\u4e2d\u5171\u540c\u5b9a\u4f4d\u3002\u6765\u81ea\u7a7a\u95f4\u591a\u7ec4\u5b66\u65b9\u6cd5\u7684\u6574\u5408\u6570\u636e\u4e00\u81f4\u6027\u5730\u8bc6\u522b\u590d\u6742\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u7c7b\u578b\u548c\u5206\u5e03\uff0c\u4ee5\u53ca\u4e00\u4e2a\u514d\u75ab\u7ec6\u80de\u4e3a\u4e3b\u5bfc\u7684\u201c\u80bf\u7624-\u6b63\u5e38\u754c\u9762\u201d\u533a\u57df\uff0c\u80bf\u7624\u7ec6\u80de\u63a5\u89e6\u76f8\u90bb\u7ec4\u7ec7\u5177\u6709\u72ec\u7279\u7684\u8f6c\u5f55\u7279\u5f81\u548c\u663e\u8457\u7684\u514d\u75ab\u4ee3\u8c22\u6539\u53d8\u3002\u6211\u4eec\u7ed8\u5236\u7ec4\u7ec7\u5206\u5b50\u7ed3\u6784\u7684\u65b9\u6cd5\u63d0\u4f9b\u4e86\u80bf\u7624\u5185\u5f02\u8d28\u6027\u7684\u9ad8\u5ea6\u6574\u5408\u753b\u50cf\uff0c\u5e76\u5728\u7cfb\u7edf\u5c42\u9762\u6539\u53d8\u4e86\u5bf9\u764c\u75c7\u4ee3\u8c22\u7684\u7406\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Immunol. 20230519<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance<\/strong><\/p>\n

PD-L1\u68c0\u67e5\u70b9\u963b\u65ad\u901a\u8fc7\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\u6d3b\u6027\u5bfc\u81f4\u6cbb\u7597\u8010\u53d7<\/strong><\/span><\/p>\n

Sci Immunol. 2023 May 19;8(83):eabn6173.<\/em><\/p>\n

doi: <\/strong>10.1126\/sciimmunol.abn6173.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37205768\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5c3d\u7ba1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u5728\u4e34\u5e8a\u4e0a\u53d6\u5f97\u4e86\u6210\u529f\uff0c\u4f46\u5728\u67d0\u4e9b\u7c7b\u578b\u7684\u764c\u75c7\u4e2d\uff0c\u5927\u591a\u6570\u764c\u75c7\u60a3\u8005\u5bf9ICB\u7684\u53cd\u5e94\u5e76\u4e0d\u7406\u60f3\u3002\u6b64\u5916\uff0c\u5728\u6700\u521d\u5bf9ICB\u6709\u6548\u7684\u60a3\u8005\u4e2d\uff0c\u8fd9\u79cd\u6210\u529f\u5f80\u5f80\u662f\u77ed\u6682\u7684\uff0c\u56e0\u4e3a\u4ed6\u4eec\u968f\u540e\u4f1a\u53d1\u5c55\u51fa\u5bf9ICB\u7684\u8010\u53d7\u3002\u76ee\u524d\u5bf9\u4e8eICB\u7684\u521d\u7ea7\u6216\u6b21\u7ea7\u8010\u836f\u673a\u5236\u5c1a\u672a\u5b8c\u5168\u4e86\u89e3\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u53d1\u73b0\u5728\u03b1PD-L1\u6cbb\u7597\u8010\u53d7\u7684\u5b9e\u4f53\u7624\u5c0f\u9f20\u4e2d\uff0c\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\u7ec6\u80de\uff09\u7684\u6fc0\u6d3b\u4f18\u5148\u8fdb\u884c\u4e14\u6291\u5236\u80fd\u529b\u589e\u5f3a\u3002Treg\u7ec6\u80de\u7684\u6d88\u8017\u53ef\u4ee5\u9006\u8f6c\u5bf9\u03b1PD-L1\u7684\u8010\u53d7\uff0c\u5e76\u4f34\u968f\u6548\u5e94T\u7ec6\u80de\u7684\u6269\u589e\u3002\u6b64\u5916\uff0c\u6211\u4eec\u53d1\u73b0\uff0c\u5728\u63a5\u53d7ICB\u6cbb\u7597\u7684\u76ae\u80a4\u764c\u60a3\u8005\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u80bf\u7624\u6d78\u6da6\u7684Treg\u7ec6\u80de\u4e0a\u8c03\u4e86\u4e00\u4e2a\u6291\u5236\u6027\u57fa\u56e0\u8f6c\u5f55\u7a0b\u5e8f\uff0c\u8fd9\u4e0e\u6cbb\u7597\u53cd\u5e94\u7684\u7f3a\u5931\u76f8\u5173\u3002\u5728\u80ba\u764c\u548c\u95f4\u76ae\u7624\u60a3\u8005\u7684\u5916\u5468\u8840\u4e2d\uff0c\u5c24\u5176\u662f\u5728\u975e\u5e94\u7b54\u8005\u4e2d\uff0c\u4e5f\u89c2\u5bdf\u5230\u03b1PD-1\/PD-L1\u8bf1\u5bfc\u7684PD-1+ Treg\u7ec6\u80de\u6fc0\u6d3b\u3002\u7efc\u5408\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u03b1PD-1\u548c\u03b1PD-L1\u7684\u6cbb\u7597\u91ca\u653e\u4e86Treg\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5bfc\u81f4\u6cbb\u7597\u8010\u53d7\uff0c\u8fd9\u8868\u660e\u9488\u5bf9Treg\u7ec6\u80de\u7684\u6cbb\u7597\u662f\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u7684\u91cd\u8981\u8f85\u52a9\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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08<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Commun. 20230506<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment<\/strong><\/p>\n

\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7684I\u578b\u5e72\u6270\u7d20\u53cd\u5e94\u901a\u8fc7\u589e\u5f3a\u5355\u6838\u9ad3\u7cfb\u7ec6\u80de\u52df\u96c6\u4fc3\u8fdb\u8111\u8f6c\u79fb<\/strong><\/span><\/p>\n

Nat Commun. 2023 May 6;14(1):2632.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-023-38252-8.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37149684\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u75c7\u8f6c\u79fb\u5230\u5927\u8111\u662f\u4e00\u4e2a\u4e25\u91cd\u7684\u4e34\u5e8a\u95ee\u9898\u3002\u8f6c\u79fb\u662f\u4fb5\u88ad\u764c\u7ec6\u80de\u4e0e\u5fae\u73af\u5883\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u8bc1\u660e\u764c\u75c7\u6fc0\u6d3b\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5728\u8111\u8f6c\u79fb\u75c5\u7076\u4e2d\u521b\u9020\u4e86\u4e00\u4e2a\u6301\u7eed\u7684\u4f4e\u6c34\u5e73\u6fc0\u6d3b\u7684I\u578b\u5e72\u6270\u7d20\uff08IFN\uff09\u5fae\u73af\u5883\u3002\u6211\u4eec\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684IFN\u53cd\u5e94\u4fc3\u8fdb\u4e86\u8111\u8f6c\u79fb\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0c\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\u7684IFN\u4fe1\u53f7\u6fc0\u6d3bC-C \u6fc0\u52a8\u5242\u8d8b\u5316\u56e0\u5b50\u914d\u4f532\uff08CCL2\uff09\u7684\u4ea7\u751f\uff0c\u8fdb\u4e00\u6b65\u589e\u52a0\u4e86\u5355\u6838\u7ec6\u80de\u6837\u9ad3\u7cfb\u7ec6\u80de\u7684\u62db\u52df\u3002\u5728\u4e34\u5e8a\u8111\u8f6c\u79fb\u6837\u672c\u4e2d\u8bc1\u5b9e\u4e86CCL2\u4e0e\u5355\u6838\u9ad3\u7cfb\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u6700\u540e\uff0c\u901a\u8fc7\u57fa\u56e0\u6216\u836f\u7269\u6291\u5236CCR2\u53ef\u6709\u6548\u51cf\u5c11\u8111\u8f6c\u79fb\u3002\u6211\u4eec\u7684\u7814\u7a76\u9610\u660e\u4e86\u5c3d\u7ba1IFN\u53cd\u5e94\u88ab\u8ba4\u4e3a\u5177\u6709\u6297\u80bf\u7624\u6548\u5e94\uff0c\u4f46\u5728\u5927\u8111\u4e2dI\u578bIFN\u5177\u6709\u4fc3\u8f6c\u79fb\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u8fd9\u9879\u5de5\u4f5c\u6269\u5c55\u4e86\u6211\u4eec\u5bf9\u764c\u75c7\u6fc0\u6d3b\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u548c\u8111\u8f6c\u79fb\u4e2d\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u7406\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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09<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Adv. 20230505<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development<\/strong><\/p>\n

\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\u8c03\u63a7\u817a\u82f7\u4ee3\u8c22\u4ee5\u4fc3\u8fdb\u809d\u764c\u53d1\u5c55<\/strong><\/span><\/p>\n

Sci Adv. 2023 May 5;9(18):eade5111.<\/em><\/p>\n

doi: <\/strong>10.1126\/sciadv.ade5111.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37146141\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7f3a\u6c27\u8bf1\u5bfc\u7684\u817a\u82f7\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u4ea7\u751f\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u964d\u4f4e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09\u7684\u7597\u6548\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b501\uff08HIF-1\uff09\u901a\u8fc7\u4e24\u4e2a\u6b65\u9aa4\u8c03\u63a7\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u4e2d\u7684\u817a\u82f7\u5916\u6392\u3002\u9996\u5148\uff0cHIF-1\u6fc0\u6d3b\u8f6c\u5f55\u6291\u5236\u56e0\u5b50MXI1\uff0c\u6291\u5236\u817a\u82f7\u6fc0\u9176\uff08ADK\uff09\uff0c\u5bfc\u81f4\u817a\u82f7\u4e0d\u80fd\u78f7\u9178\u5316\u4e3a\u817a\u82f7\u5355\u78f7\u9178\u3002\u8fd9\u5bfc\u81f4\u7f3a\u6c27\u764c\u7ec6\u80de\u4e2d\u817a\u82f7\u7684\u79ef\u7d2f\u3002\u5176\u6b21\uff0cHIF-1\u8f6c\u5f55\u6fc0\u6d3b\u7b49\u6e17\u6838\u82f7\u8f6c\u8fd0\u86cb\u767d4\uff0c\u5c06\u817a\u82f7\u6cf5\u5165HCC\u7684\u95f4\u8d28\u7a7a\u95f4\uff0c\u63d0\u9ad8\u7ec6\u80de\u5916\u817a\u82f7\u6c34\u5e73\u3002\u591a\u79cd\u4f53\u5916\u5b9e\u9a8c\u5c55\u793a\u4e86\u817a\u82f7\u5bf9T\u7ec6\u80de\u548c\u9ad3\u6837\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002\u4f53\u5185\u6572\u9664ADK\u4f7f\u80bf\u7624\u5185\u514d\u75ab\u7ec6\u80de\u504f\u5411\u4fc3\u80bf\u7624\uff0c\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\u3002\u5728\u6cbb\u7597\u4e0a\uff0c\u817a\u82f7\u53d7\u4f53\u62ee\u6297\u5242\u4e0e\u6297PD-1\u7684\u8054\u5408\u6cbb\u7597\u5ef6\u957f\u4e86HCC\u60a3\u8005\u5c0f\u9f20\u7684\u751f\u5b58\u65f6\u95f4\u3002\u6211\u4eec\u9610\u660e\u4e86\u7f3a\u6c27\u5728\u5efa\u7acb\u817a\u82f7\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236TME\u4e2d\u7684\u53cc\u91cd\u4f5c\u7528\uff0c\u5e76\u63d0\u4f9b\u4e86\u4e00\u79cd\u53ef\u80fd\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4e0eHCC\u4e2d\u7684ICIs\u534f\u540c\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10<\/strong><\/p>\n<\/section>\n<\/section>\n

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Signal Transduct Target Ther. 20230519<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer<\/strong><\/p>\n

JAK-STAT\u4fe1\u53f7\u901a\u8def\u7684\u8ba4\u77e5\u6f14\u53d8\uff1a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u764c\u75c7<\/strong><\/span><\/p>\n

Signal Transduct Target Ther. 2023 May 19;8(1):204.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41392-023-01468-7.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37208335\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

Janus\u6fc0\u9176\uff08JAK\uff09\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50\u901a\u8def\uff08JAK-STAT\uff09\u662f\u4e00\u79cd\u8fdb\u5316\u4fdd\u5b88\u7684\u8de8\u819c\u4fe1\u53f7\u8f6c\u5bfc\u673a\u5236\uff0c\u4f7f\u7ec6\u80de\u80fd\u591f\u4e0e\u5916\u90e8\u73af\u5883\u8fdb\u884c\u901a\u4fe1\u3002\u5404\u79cd\u7ec6\u80de\u56e0\u5b50\u3001\u5e72\u6270\u7d20\u3001\u751f\u957f\u56e0\u5b50\u548c\u5176\u4ed6\u7279\u5f02\u6027\u5206\u5b50\u6fc0\u6d3bJAK-STAT\u4fe1\u53f7\u4f20\u5bfc\uff0c\u9a71\u52a8\u4e00\u7cfb\u5217\u751f\u7406\u548c\u75c5\u7406\u8fc7\u7a0b\uff0c\u5305\u62ec\u589e\u6b96\u3001\u4ee3\u8c22\u3001\u514d\u75ab\u5e94\u7b54\u3001\u708e\u75c7\u548c\u6076\u6027\u8f6c\u5316\u3002\u5931\u8c03\u7684JAK-STAT\u4fe1\u53f7\u4f20\u5bfc\u53ca\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u4e0e\u514d\u75ab\u6fc0\u6d3b\u548c\u764c\u75c7\u8fdb\u5c55\u5bc6\u5207\u76f8\u5173\u3002\u5bf9JAK-STAT\u901a\u8def\u7684\u7ed3\u6784\u548c\u529f\u80fd\u7684\u4e86\u89e3\u5df2\u7ecf\u5bfc\u81f4\u4e86\u591a\u79cd\u836f\u7269\u7684\u5f00\u53d1\u548c\u6279\u51c6\uff0c\u7528\u4e8e\u75be\u75c5\u7684\u4e34\u5e8a\u6cbb\u7597\u3002\u76ee\u524d\uff0c\u5df2\u5f00\u53d1\u51fa\u7684\u836f\u7269\u4e3b\u8981\u9488\u5bf9JAK-STAT\u901a\u8def\uff0c\u901a\u5e38\u5206\u4e3a\u4e09\u4e2a\u4e9a\u578b\uff1a\u7ec6\u80de\u56e0\u5b50\u6216\u53d7\u4f53\u6297\u4f53\u3001JAK\u6291\u5236\u5242\u548cSTAT\u6291\u5236\u5242\u3002\u65b0\u578b\u836f\u7269\u4e5f\u7ee7\u7eed\u5728\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u5f00\u53d1\u548c\u6d4b\u8bd5\u3002\u6bcf\u79cd\u836f\u7269\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u5728\u6295\u5165\u4e34\u5e8a\u5e94\u7528\u4e4b\u524d\u4e5f\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u79d1\u5b66\u8bd5\u9a8c\u6765\u8bc1\u5b9e\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u56de\u987e\u4e86\u76ee\u524d\u5bf9JAK-STAT\u4fe1\u53f7\u901a\u8def\u7684\u57fa\u672c\u7ec4\u6210\u548c\u529f\u80fd\u7684\u7406\u89e3\u3002\u6211\u4eec\u8fd8\u8ba8\u8bba\u4e86\u5173\u4e8eJAK-STAT\u76f8\u5173\u81f4\u75c5\u673a\u5236\u7684\u8ba4\u77e5\u8fdb\u6b65\uff1b\u9488\u5bf9\u5404\u79cd\u75be\u75c5\uff08\u5c24\u5176\u662f\u514d\u75ab\u6027\u75be\u75c5\u548c\u764c\u75c7\uff09\u7684\u9776\u5411JAK-STAT\u6cbb\u7597\uff1b\u65b0\u5f00\u53d1\u7684JAK\u6291\u5236\u5242\uff1b\u4ee5\u53ca\u8be5\u9886\u57df\u76ee\u524d\u9762\u4e34\u7684\u6311\u6218\u548c\u53d1\u5c55\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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11<\/strong><\/p>\n<\/section>\n<\/section>\n

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Signal Transduct Target Ther. 20230522<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Macrophages in immunoregulation and therapeutics<\/strong><\/p>\n

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Signal Transduct Target Ther. 2023 May 22;8(1):207.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41392-023-01452-1.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37211559\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

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Nat Rev Immunol. 20230425<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1<\/strong><\/p>\n

\u4ece30\u5e74\u7684\u5386\u7a0b\u4e2d\u83b7\u5f97\u7684\u542f\u793a\uff1aPD1\u7684\u529f\u80fd\u3001\u8c03\u63a7\u548c\u6cbb\u7597\u8c03\u8282<\/strong><\/span><\/p>\n

Nat Rev Immunol. 2023 Apr 25.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41577-023-00867-9.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37185300\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

PD1\u6700\u521d\u4e8e1992\u5e74\u88ab\u53d1\u73b0\uff0c\u4e3aT\u7ec6\u80de\u6fc0\u6d3b\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u7684\u5206\u5b50\u3002\u5728\u8fc7\u53bb\u768430\u5e74\u4e2d\uff0c\u4eba\u4eec\u53d1\u73b0PD1\u5728\u907f\u514d\u8fc7\u5ea6\u6fc0\u6d3b\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u5177\u6709\u5173\u952e\u4f5c\u7528\uff0c\u800c\u5176\u6291\u5236\u5219\u53ef\u6fc0\u6d3b\u6297\u764c\u514d\u75ab\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u6982\u8ff0\u4e86\u4ecePD1\u7684\u53d1\u73b0\u5230\u5176\u4f5c\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7a81\u7834\u6027\u9776\u70b9\u7684\u8fc7\u7a0b\u3002\u6211\u4eec\u63cf\u8ff0\u4e86PD1\u7684\u8c03\u63a7\u548c\u529f\u80fd\uff0c\u5e76\u63a2\u8ba8\u4e86PD1\u4fe1\u53f7\u4f20\u5bfc\u5728\u8bbe\u5b9aT\u7ec6\u80de\u6fc0\u6d3b\u9608\u503c\u4e2d\u7684\u6838\u5fc3\u529f\u80fd\u53ca\u53d1\u6325\u8fd9\u79cd\u529f\u80fd\u7684\u673a\u5236\uff0c\u4ece\u800c\u63a7\u5236T\u7ec6\u80de\u7684\u589e\u6b96\u3001\u5206\u5316\u3001\u8017\u7aed\u548c\u4ee3\u8c22\u72b6\u6001\u3002\u8fd9\u4e00\u9608\u503c\u7406\u8bba\uff0c\u7ed3\u5408\u5bf9T\u7ec6\u80de\u4ee3\u8c22\u7684\u65b0\u89c1\u89e3\u548c\u5bf9\u514d\u75ab\u7ec6\u80de\u53d7\u5fae\u751f\u7269\u7fa4\u8c03\u63a7\u7684\u66f4\u597d\u7406\u89e3\uff0c\u53ef\u4ee5\u4e3a\u5f00\u53d1\u9ad8\u6548\u8054\u5408\u6cbb\u7597\u63d0\u4f9b\u6307\u5bfc\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86PD1\u9776\u5411\u6cbb\u7597\u540e\u4ea7\u751f\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u7684\u673a\u5236\u53ca\u5176\u53ef\u80fd\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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13<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Metab. 20230505<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment<\/strong><\/p>\n

\u764c\u7ec6\u80de\u6765\u6e90\u7684\u5ef6\u80e1\u7d22\u9178\u6291\u5236\u80bf\u7624\u5fae\u73af\u5883\u4e2dCD8+ T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u80fd\u529b<\/strong><\/span><\/p>\n

Cell Metab. 2023 May 5;S1550-4131(23)00171-7.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cmet.2023.04.017.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37178684\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5728\u5fae\u73af\u5883\u4e2d\uff0c\u4ee3\u8c22\u7684\u53d8\u5316\u80fd\u591f\u663e\u8457\u5730\u8c03\u8282\u80bf\u7624\u7684\u514d\u75ab\u654f\u611f\u6027\uff0c\u4f46\u662f\u5176\u6f5c\u5728\u673a\u5236\u76ee\u524d\u5c1a\u672a\u5b8c\u5168\u6e05\u695a\u3002\u672c\u7814\u7a76\u62a5\u544a\u4e86\u5ef6\u80e1\u7d22\u9178\u6c34\u5408\u9176\uff08FH\uff09\u7f3a\u5931\u5bf9\u80bf\u7624\u4ea7\u751f\u7684\u5f71\u54cd\uff0c\u53d1\u73b0FH\u7f3a\u5931\u7684\u80bf\u7624\u53ef\u4ee5\u6291\u5236\u529f\u80fd\u6027CD8+ T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3001\u6269\u589e\u548c\u6548\u529b\uff0c\u540c\u65f6\u589e\u5f3a\u6076\u6027\u589e\u6b96\u80fd\u529b\u3002\u673a\u5236\u4e0a\u6765\u770b\uff0cFH\u7f3a\u5931\u5bfc\u81f4\u80bf\u7624\u95f4\u8d28\u6db2\u4e2d\u5ef6\u80e1\u7d22\u9178\u7684\u79ef\u7d2f\uff0c\u8fc7\u91cf\u7684\u5ef6\u80e1\u7d22\u9178\u53ef\u4ee5\u76f4\u63a5\u4f7f\u5f97ZAP70\u5728C96\u548cC102\u4f4d\u70b9\u916e\u620a\u4e8c\u9178\u5316\uff0c\u4ece\u800c\u6291\u5236\u6d78\u6da6CD8+ T\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u5bfc\u81f4\u4f53\u5185\u5916CD8+ T\u7ec6\u80de\u6fc0\u6d3b\u548c\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u53d7\u5230\u6291\u5236\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u63d0\u9ad8FH\u8868\u8fbe\u4ee5\u964d\u4f4e\u5ef6\u80e1\u7d22\u9178\u542b\u91cf\uff0c\u53ef\u4ee5\u663e\u8457\u589e\u5f3a\u6297CD19 CAR T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6548\u529b\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u53d1\u73b0\u63ed\u793a\u4e86\u5ef6\u80e1\u7d22\u9178\u5728\u63a7\u5236TCR\u4fe1\u53f7\u4e2d\u7684\u4f5c\u7528\uff0c\u540c\u65f6\u8868\u660e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5ef6\u80e1\u7d22\u9178\u7684\u79ef\u7d2f\u662fCD8+ T\u7ec6\u80de\u6297\u80bf\u7624\u529f\u80fd\u7684\u4e00\u4e2a\u4ee3\u8c22\u969c\u788d\u3002\u6f5c\u5728\u5730\uff0c\u5ef6\u80e1\u7d22\u9178\u7684\u8017\u7aed\u53ef\u80fd\u6210\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u4e00\u4e2a\u91cd\u8981\u7b56\u7565\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CD8(+) T\u7ec6\u80de\u6fc0\u6d3b; FH; ZAP70; \u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54; \u5ef6\u80e1\u7d22\u9178; \u5ef6\u80e1\u7d22\u9178\u6c34\u5408\u9176; \u916e\u620a\u4e8c\u9178\u5316; \u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gut. 20230525<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas<\/strong><\/p>\n

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Gut. 2023 May 25;gutjnl-2022-328697.<\/em><\/p>\n

doi: <\/strong>10.1136\/gutjnl-2022-328697.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37230755\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u76ee\u7684\uff1a<\/strong>\u672c\u7814\u7a76\u65e8\u5728\u6df1\u5165\u4e86\u89e3\u80f0\u817a\u5bfc\u7ba1\u764c\uff08PDAC\uff09\u7684\u514d\u75ab\u5fae\u73af\u5883\uff0c\u63a2\u8ba8T\u7ec6\u80de\u548cB\u7ec6\u80de\u5728\u4e09\u7ea7\u6dcb\u5df4\u7ed3\u7ed3\u6784\uff08TLS\uff09\u4e2d\u7684\u5206\u5e03\u4e0e\u4ea7\u751f\u5c40\u90e8\u6297\u80bf\u7624\u514d\u75ab\u7684\u76f8\u5173\u6027\u3002<\/p>\n

\u8bbe\u8ba1\uff1a<\/strong>\u6211\u4eec\u4f7f\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u3001\u6d41\u5f0f\u7ec6\u80de\u672f\u3001\u591a\u8272\u514d\u75ab\u8367\u5149\u3001\u5fae\u5207\u5272TLS\u57fa\u56e0\u8868\u8fbe\u8c31\u4ee5\u53ca\u4f53\u5916\u5b9e\u9a8c\u7b49\u591a\u79cd\u6280\u672f\u624b\u6bb5\uff0c\u5bf9PDAC\u6d78\u6da6T\u7ec6\u80de\u548cB\u7ec6\u80de\u7684\u529f\u80fd\u72b6\u6001\u548c\u7a7a\u95f4\u7ec4\u7ec7\u8fdb\u884c\u4e86\u8868\u5f81\u3002\u540c\u65f6\uff0c\u6211\u4eec\u4f7f\u7528\u6765\u81ea8\u79cd\u764c\u75c7\u7c7b\u578b\u7684scRNA-seq\u548csc T\u7ec6\u80de\u53d7\u4f53\u6d4b\u5e8f\u6570\u636e\u96c6\uff0c\u5bf9\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u8fdb\u884c\u5168\u764c\u75c7\u5206\u6790\u3002\u6700\u540e\uff0c\u6211\u4eec\u8fd8\u4f7f\u7528\u6765\u81ea\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\u548cPRINCE\u5316\u7597\u514d\u75ab\u6cbb\u7597\u8bd5\u9a8c\u7684PDAC\u6574\u4f53RNA-seq\u6570\u636e\uff0c\u8bc4\u4f30\u4e86\u6211\u4eec\u53d1\u73b0\u7684\u4e34\u5e8a\u76f8\u5173\u6027\u3002<\/p>\n

\u7ed3\u679c\uff1a<\/strong>\u6211\u4eec\u53d1\u73b0PDAC\u7684\u4e00\u90e8\u5206\u60a3\u8005\u5177\u6709\u5b8c\u5168\u53d1\u80b2\u7684TLS\uff0c\u5176\u4e2dB\u7ec6\u80de\u53ef\u4ee5\u589e\u6b96\u5e76\u5206\u5316\u4e3a\u6d46\u7ec6\u80de\u3002\u8fd9\u4e9b\u6210\u719f\u7684TLS\u4e0d\u4ec5\u652f\u6301T\u7ec6\u80de\u6d3b\u6027\uff0c\u800c\u4e14\u5bcc\u96c6\u6709\u80bf\u7624\u53cd\u5e94\u6027T\u7ec6\u80de\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6211\u4eec\u8bc1\u660e\u4e86\u957f\u671f\u6fc0\u6d3b\u7684\u80bf\u7624\u53cd\u5e94\u6027T\u7ec6\u80de\u53ef\u80fd\u901a\u8fc7\u4ea7\u751fB\u7ec6\u80de\u8d8b\u5316\u56e0\u5b50CXCL13\u5145\u5f53TLS\u7ec4\u7ec7\u8005\uff0c\u5e76\u66b4\u9732\u4e8e\u6210\u7ea4\u7ef4\u7ec6\u80de\u6765\u6e90\u7684TGF-\u03b2\u3002\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\uff0c\u6211\u4eec\u8fd8\u53d1\u73b0\u4e86\u9ad8\u5ea6\u76f8\u4f3c\u7684\u514b\u9686\u6269\u589eCXCL13+\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u5b50\u96c6\uff0c\u8fdb\u4e00\u6b65\u8868\u660e\u80bf\u7624\u6297\u539f\u8bc6\u522b\u4e0eB\u7ec6\u80de\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u53d7\u4fdd\u62a4\u7684\u67a2\u7ebd\u4e4b\u95f4\u5b58\u5728\u7740\u4fdd\u5b88\u7684\u8054\u7cfb\u3002\u6700\u540e\uff0c\u6211\u4eec\u8bc1\u5b9e\u4e86\u5728\u63a5\u53d7\u4e0d\u540c\u5316\u7597\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u540e\u751f\u5b58\u65f6\u95f4\u8f83\u957f\u7684PDAC\u60a3\u8005\u7684\u9884\u5904\u7406\u6d3b\u68c0\u4e2d\uff0c\u8868\u8fbe\u53cd\u6620\u6210\u719fTLS\u7684\u57fa\u56e0\u7279\u5f81\u3002<\/p>\n

\u7ed3\u8bba\uff1a<\/strong>\u672c\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6846\u67b6\uff0c\u6df1\u5165\u7406\u89e3\u4e0ePDAC\u76f8\u5173\u7684TLS\u7684\u751f\u7269\u5b66\u4f5c\u7528\uff0c\u5e76\u63ed\u793a\u4e86\u5b83\u4eec\u5728\u6307\u5bfc\u672a\u6765\u514d\u75ab\u6cbb\u7597\u8bd5\u9a8c\u60a3\u8005\u7b5b\u9009\u65b9\u9762\u7684\u6f5c\u529b\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u514d\u75ab\u5e94\u7b54\uff1b\u80f0\u817a\u764c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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15<\/strong><\/p>\n<\/section>\n<\/section>\n

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Science. 20230526<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse<\/strong><\/p>\n

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Science. 2023 May 26;380(6647):818-823.<\/em><\/p>\n

doi: <\/strong>10.1126\/science.abp8933.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37228189\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTLs\uff09\u901a\u8fc7T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u8bc6\u522b\u6765\u6d88\u706d\u75c5\u6bd2\u611f\u67d3\u548c\u764c\u7ec6\u80de\u3002\u5982\u4f55\u7ec8\u6b62CTLs\u7684\u4fe1\u53f7\u4f20\u5bfc\u5e76\u4f7f\u5176\u8131\u79bb\u4ee5\u5141\u8bb8\u8fde\u7eed\u6740\u4f24\u4ecd\u7136\u662f\u4e2a\u8c1c\u3002TCR\u6fc0\u6d3b\u89e6\u53d1\u514d\u75ab\u7a81\u89e6\u5185\u7684\u819c\u53d1\u751f\u7279\u5316\uff0c\u5305\u62ec\u4ea7\u751f\u4e8c\u9170\u7518\u6cb9\uff08DAG\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u53ef\u4ee5\u8bf1\u5bfc\u8d1f\u6027\u819c\u66f2\u7387\u7684\u8102\u8d28\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u6fc0\u6d3b\u7684TCRs\u5728\u514d\u75ab\u7a81\u89e6\u4e2d\u88ab\u6392\u653e\u5230\u5bcc\u542bDAG\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\u4e2d\uff0c\u800c\u4e0d\u662f\u901a\u8fc7\u5185\u541e\u4f5c\u7528\u5185\u5316\uff0c\u8fd9\u8868\u660eDAG\u53ef\u80fd\u6709\u52a9\u4e8e\u7ec6\u80de\u5916\u56ca\u6ce1\u5f62\u6210\u6240\u9700\u7684\u5411\u5916\u7a81\u51fa\u3002\u7a81\u51fa\u7684\u7ec6\u80de\u5916\u56ca\u6ce1\u88ab\u9776\u7ec6\u80de\u76f4\u63a5\u5185\u541e\uff0c\u4ece\u800c\u7ec8\u6b62TCR\u4fe1\u53f7\u4f20\u5bfc\u5e76\u540c\u65f6\u4f7fCTL\u4ece\u9776\u7ec6\u80de\u8131\u79bb\u4ee5\u5141\u8bb8\u8fde\u7eed\u6740\u4f24\u3002\u56e0\u6b64\uff0c\u7ec6\u80de\u5916\u56ca\u6ce1\u4f7fTCR\u4fe1\u53f7\u4f20\u5bfc\u5177\u6709\u81ea\u6211\u9650\u5236\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Endocytosis in cancer and cancer therapy<\/strong><\/p>\n

\u764c\u75c7\u548c\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u5185\u541e\u4f5c\u7528<\/strong><\/span><\/p>\n

Nat Rev Cancer. 2023 May 22.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41568-023-00574-6.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37217781\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

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\u2014 THE  END \u2014<\/span><\/section>\n
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\u7b5b\u9009\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n


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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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