{"id":5128,"date":"2023-08-10T19:01:44","date_gmt":"2023-08-10T11:01:44","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/10\/monthly-updates-2023-07\/"},"modified":"2025-01-03T18:49:39","modified_gmt":"2025-01-03T10:49:39","slug":"monthly-updates-2023-07","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/10\/monthly-updates-2023-07\/","title":{"rendered":"Monthly Updates 2023.07"},"content":{"rendered":"
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Monthly Updates 2023.06<\/a><\/p>\n

Monthly Updates 2023.05<\/a><\/p>\n

Monthly Updates 2023.04<\/a><\/p>\n

Monthly Updates 2023.03<\/a><\/p>\n

Monthly Updates 2023.02<\/a><\/p>\n

Monthly Updates 2023.01<\/a><\/p>\n

Monthly Updates 2022.12<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Metab. 20230628<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Cell Metab. 2023 Jun 28;S1550-4131(23)00215-2.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cmet.2023.06.005. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37413991\/<\/span><\/p>\n

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\u80bf\u7624\u7ec6\u80de\u8868\u578b\u548c\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u53d7\u5230\u5c40\u90e8\u4ee3\u8c22\u7269\u7684\u5f71\u54cd\uff0c\u4f46\u5bf9\u80bf\u7624\u5185\u90e8\u4ee3\u8c22\u7269\u5f02\u8d28\u6027\uff08IMH\uff09\u53ca\u5176\u8868\u578b\u540e\u679c\u7684\u7406\u89e3\u4ecd\u7136\u8f83\u4e3a\u6b20\u7f3a\u3002\u4e3a\u4e86\u7814\u7a76 IMH\uff0c\u6211\u4eec\u5bf9\u80be\u900f\u660e\u7ec6\u80de\u764c\uff08ccRCC\uff09\u60a3\u8005\u7684\u80bf\u7624\/\u6b63\u5e38\u533a\u57df\u8fdb\u884c\u4e86\u5206\u6790\u3002\u6240\u6709\u60a3\u8005\u90fd\u8868\u73b0\u51fa IMH \u7684\u5e38\u89c1\u6a21\u5f0f\uff0c\u5176\u7279\u5f81\u662f\u4e0e\u94c1\u6b7b\u4ea1\u76f8\u5173\u7684\u4ee3\u8c22\u7269\u548c\u8fc7\u7a0b\u7684\u4e30\u5ea6\u5448\u76f8\u5173\u6ce2\u52a8\u3002\u5bf9\u80bf\u7624\u5185\u90e8\u4ee3\u8c22\u7269-RNA \u534f\u53d8\u7684\u5206\u6790\u63ed\u793a\u4e86\u5fae\u73af\u5883\u7684\u514d\u75ab\u7ec4\u6210\uff0c\u7279\u522b\u662f\u9ad3\u6837\u7ec6\u80de\u7684\u4e30\u5ea6\uff0c\u9a71\u52a8\u4e86\u80bf\u7624\u5185\u90e8\u4ee3\u8c22\u7269\u7684\u53d8\u5316\u3002\u7531\u4e8e RNA-\u4ee3\u8c22\u7269\u534f\u53d8\u7684\u5f3a\u5ea6\u4ee5\u53ca ccRCC \u4e2d RNA \u751f\u7269\u6807\u5fd7\u7269\u7684\u4e34\u5e8a\u610f\u4e49\uff0c\u6211\u4eec\u4ece\u53c2\u52a0\u4e867\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684 ccRCC \u60a3\u8005\u7684 RNA \u6d4b\u5e8f\u6570\u636e\u4e2d\u63a8\u65ad\u51fa\u4e86\u4ee3\u8c22\u7ec4\u5b66\u7279\u5f81\uff0c\u5e76\u6700\u7ec8\u786e\u5b9a\u4e86\u4e0e\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u53cd\u5e94\u76f8\u5173\u7684\u4ee3\u8c22\u7269\u751f\u7269\u6807\u5fd7\u7269\u3002\u56e0\u6b64\uff0c\u5c40\u90e8\u4ee3\u8c22\u8868\u578b\u4e0e\u514d\u75ab\u5fae\u73af\u5883\u5171\u540c\u5f71\u54cd\u7740\u6b63\u5728\u8fdb\u884c\u7684\u80bf\u7624\u6f14\u53d8\uff0c\u5e76\u4e0e\u6cbb\u7597\u654f\u611f\u6027\u76f8\u5173\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

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02<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20230705<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nature. 2023 Jul 5.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-06299-8. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37407815\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Rev Cancer. 20230703<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nat Rev Cancer. 2023 Jul 3.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41568-023-00594-2. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37400581\/<\/span><\/p>\n

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04<\/strong><\/p>\n<\/section>\n<\/section>\n

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Trends Cancer. 20230701<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Trends Cancer. 2023 Jul 1;S2405-8033(23)00104-8. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.trecan.2023.06.003. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37400315\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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05<\/strong><\/p>\n<\/section>\n<\/section>\n

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Immunity. 20230627<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Immunity. 2023 Jun 27;S1074-7613(23)00260-1. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.immuni.2023.06.003. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37392735\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u6d78\u6da6\uff0c\u4e00\u79cd\u5177\u6709\u514d\u75ab\u6291\u5236\u529f\u80fd\u7684CD4+ T\u7ec6\u80de\u7fa4\u4f53\uff0c\u8fdb\u5165\u5b9e\u4f53\u80bf\u7624\u6784\u6210\u4e86\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u969c\u788d\u3002\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u5bf9\u4e8eTreg\u7ec6\u80de\u7684\u62db\u52df\u548c\u708e\u75c7\u7ec4\u7ec7\uff08\u5305\u62ec\u764c\u75c7\uff09\u4e2d\u7684\u7ec6\u80de-\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u6b64\u662f\u7406\u60f3\u7684\u6cbb\u7597\u76ee\u6807\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5728\u591a\u79cd\u764c\u75c7\u6a21\u578b\u4e2d\u663e\u793a\uff0c\u4e0e\u6dcb\u5df4\u7ec4\u7ec7\u76f8\u6bd4\uff0c\u80bf\u7624\u4e2d\u7684CXCR3+ Treg\u7ec6\u80de\u6570\u91cf\u589e\u52a0\uff0c\u5448\u73b0\u51fa\u4e00\u79cd\u6fc0\u6d3b\u7684\u8868\u578b\uff0c\u5e76\u4e0e\u4ea7\u751fCXCL9\u7684BATF3+\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u6709\u4f18\u5148\u7684\u4ea4\u4e92\u3002\u5728Treg\u7ec6\u80de\u4e2d\u9057\u4f20\u6027\u6d88\u9664CXCR3\uff0c\u7834\u574f\u4e86DC1-Treg\u7ec6\u80de\u4ea4\u4e92\uff0c\u540c\u65f6\u589e\u52a0\u4e86DC-CD8+ T\u7ec6\u80de\u7684\u4ea4\u4e92\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cTreg\u7ec6\u80de\u4e2d\u7684CXCR3\u6d88\u9664\u589e\u52a0\u4e86DC1\u5bf9\u80bf\u7624\u6297\u539f\u7684\u7279\u5f02\u6027\u8de8\u5448\u9012\uff0c\u589e\u52a0\u4e86\u80bf\u7624\u4e2dCD8+ T\u7ec6\u80de\u7684\u542f\u52a8\u548c\u91cd\u65b0\u6fc0\u6d3b\u3002\u8fd9\u6700\u7ec8\u963b\u788d\u4e86\u80bf\u7624\u7684\u8fdb\u5c55\uff0c\u5c24\u5176\u662f\u4e0e\u6297PD-1\u68c0\u67e5\u70b9\u963b\u65ad\u514d\u75ab\u7597\u6cd5\u7ed3\u5408\u4f7f\u7528\u65f6\u3002\u603b\u7684\u6765\u8bf4\uff0cCXCR3\u88ab\u8bc1\u660e\u662fTreg\u7ec6\u80de\u5728\u80bf\u7624\u4e2d\u7684\u79ef\u7d2f\u548c\u514d\u75ab\u6291\u5236\u7684\u5173\u952e\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

CXCR3; Tregs; \u764c\u75c7; \u68c0\u67e5\u70b9\u963b\u65ad; \u4ea4\u53c9\u5448\u9012; \u6811\u7a81\u72b6\u7ec6\u80de; \u514d\u75ab\u7597\u6cd5; \u8c03\u8282\u6027T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Metab. 20230620<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e5e\u4e10\u7684\u76db\u5bb4\uff1a\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u4ee3\u8c22\u4e0e\u764c\u75c7\u6cbb\u7597<\/strong>
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Cell Metab. 2023 Jun 20;S1550-4131(23)00213-9. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.cmet.2023.06.003. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37390822\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684\u4ee3\u8c22\u7f16\u7a0b\u6539\u53d8\u4e86\u8377\u7624\u5c0f\u9f20\u548c\u764c\u75c7\u60a3\u8005\u7684\u80bf\u7624\u514d\u75ab\u548c\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u56de\u987e\u4e86TME\u4e2d\u6838\u5fc3\u4ee3\u8c22\u9014\u5f84\u3001\u5173\u952e\u4ee3\u8c22\u7269\u548c\u5173\u952e\u8425\u517b\u7269\u8f6c\u8fd0\u4f53\u7684\u4e0e\u514d\u75ab\u76f8\u5173\u7684\u529f\u80fd\uff0c\u8ba8\u8bba\u4e86\u5b83\u4eec\u5bf9\u80bf\u7624\u514d\u75ab\u548c\u514d\u75ab\u7597\u6cd5\u7684\u4ee3\u8c22\u3001\u4fe1\u53f7\u548c\u8868\u89c2\u9057\u4f20\u5f71\u54cd\uff0c\u5e76\u63a2\u8ba8\u4e86\u5982\u4f55\u5c06\u8fd9\u4e9b\u89c1\u89e3\u5e94\u7528\u5230\u5f00\u53d1\u66f4\u6709\u6548\u7684\u65b9\u5f0f\u6765\u589e\u5f3aT\u7ec6\u80de\u7684\u529f\u80fd\u5e76\u4f7f\u80bf\u7624\u7ec6\u80de\u5bf9\u514d\u75ab\u653b\u51fb\u66f4\u654f\u611f\uff0c\u4ece\u800c\u514b\u670d\u6cbb\u7597\u6297\u6027\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

T\u7ec6\u80de\uff1b\u68c0\u67e5\u70b9\uff1b\u514d\u75ab\u7597\u6cd5\uff1b\u4ee3\u8c22\uff1b\u4ee3\u8c22\u7269\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Adv. 20230630<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5355\u6838MDSCs\u901a\u8fc7\u817a\u82f7\u53d1\u6325\u66f4\u5f3a\u7684\u514d\u75ab\u6291\u5236\u6548\u679c\uff0c\u6e05\u9664\u817a\u82f7\u53ef\u63d0\u5347\u514d\u75ab\u7597\u6cd5\u7684\u6709\u6548\u6027<\/strong>
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Sci Adv. 2023 Jun 30;9(26):eadg3736.<\/em><\/p>\n

doi: <\/strong>10.1126\/sciadv.adg3736. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37390211\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u7597\u6cd5\u5bf9\u8bb8\u591a\u764c\u75c7\u7684\u4e00\u90e8\u5206\u60a3\u8005\u6709\u6548\uff1b\u5927\u90e8\u5206\u60a3\u8005\u5bf9\u8fd9\u79cd\u7597\u6cd5\u4ecd\u7136\u6ca1\u6709\u53cd\u5e94\u3002\u5bfc\u81f4ICI\u62b5\u6297\u7684\u4e00\u4e2a\u56e0\u7d20\u662f\u5355\u6838\u578b\u9aa8\u9ad3\u6291\u5236\u7ec6\u80de\uff08M-MDSCs\uff09\u7684\u79ef\u7d2f\uff0c\u8fd9\u662f\u4e00\u79cd\u5bf9T\u6dcb\u5df4\u7ec6\u80de\u5177\u6709\u5f3a\u5927\u514d\u75ab\u6291\u5236\u6d3b\u6027\u7684\u5148\u5929\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u4f7f\u7528\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u548c\u4e73\u817a\u764c\u5c0f\u9f20\u6a21\u578b\uff0c\u663e\u793a\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u8868\u8fbeCD73\u7684M-MDSCs\u8868\u73b0\u51fa\u66f4\u5f3a\u7684T\u7ec6\u80de\u6291\u5236\u529f\u80fd\u3002\u80bf\u7624\u6e90\u6027PGE2\uff0c\u4e00\u79cd\u524d\u5217\u817a\u7d20\uff0c\u76f4\u63a5\u901a\u8fc7Stat3\u548cCREB\u8bf1\u5bfcM-MDSCs\u4e2d\u7684CD73\u8868\u8fbe\u3002\u7ed3\u679cCD73\u8fc7\u8868\u8fbe\u5bfc\u81f4\u817a\u82f7\u6c34\u5e73\u5347\u9ad8\uff0c\u817a\u82f7\u662f\u4e00\u79cd\u5177\u6709T\u7ec6\u80de\u6291\u5236\u6d3b\u6027\u7684\u6838\u82f7\uff0c\u6700\u7ec8\u5bfc\u81f4\u6297\u80bf\u7624CD8+ T\u7ec6\u80de\u6d3b\u6027\u7684\u6291\u5236\u3002\u901a\u8fc7\u836f\u7269\u805a\u4e59\u4e8c\u9187\u5316\u817a\u82f7\u8131\u6c28\u9176\uff08PEG-ADA\uff09\u5728TME\u4e2d\u6d88\u8017\u817a\u82f7\uff0c\u53ef\u4ee5\u589e\u52a0CD8+ T\u7ec6\u80de\u7684\u6d3b\u6027\u5e76\u589e\u5f3a\u5bf9ICI\u7597\u6cd5\u7684\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4f7f\u7528PEG-ADA\u53ef\u4ee5\u6210\u4e3a\u514b\u670d\u764c\u75c7\u60a3\u8005\u5bf9ICI\u62b5\u6297\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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08<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230627<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u80c3\u817a\u764c\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u514d\u75ab\u548c\u57fa\u8d28\u7ec6\u80de\u72b6\u6001\u53ca\u751f\u6001\u578b\u7684\u6f14\u53d8<\/strong>
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Cancer Cell. 2023 Jun 27;S1535-6108(23)00215-5. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.06.005. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37419119\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u7406\u89e3\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u5728\u80c3\u817a\u764c\uff08GAC\uff09\u8fdb\u5c55\u4e2d\u7684\u91cd\u7f16\u7a0b\u53ef\u80fd\u4f1a\u53d1\u73b0\u65b0\u7684\u6cbb\u7597\u9776\u70b9\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5bf9\u764c\u524d\u75c5\u53d8\u3001\u5c40\u90e8\u548c\u8f6c\u79fb\u6027GAC\u8fdb\u884c\u4e86\u5355\u7ec6\u80de\u5206\u6790\uff0c\u8bc6\u522b\u51faGAC\u8fdb\u5c55\u8fc7\u7a0b\u4e2dTME\u7ec6\u80de\u72b6\u6001\u548c\u7ec4\u6210\u7684\u6539\u53d8\u3002\u4e30\u5bcc\u7684IgA+\u6d46\u7ec6\u80de\u5b58\u5728\u4e8e\u764c\u524d\u5fae\u73af\u5883\u4e2d\uff0c\u800c\u514d\u75ab\u6291\u5236\u7684\u9ad3\u6837\u548c\u57fa\u8d28\u4e9a\u7fa4\u5219\u5728\u665a\u671fGAC\u4e2d\u5360\u4e3b\u5bfc\u3002\u6211\u4eec\u786e\u5b9a\u4e86\u516d\u79cdTME\u751f\u6001\u578b\uff08EC1-6\uff09\u3002EC1\u4ec5\u5728\u8840\u6db2\u4e2d\u5b58\u5728\uff0c\u800cEC4\u3001EC5\u548cEC2\u5219\u5728\u65e0\u5173\u7ec4\u7ec7\u3001\u764c\u524d\u75c5\u53d8\u548c\u8f6c\u79fb\u7624\u4e2d\u9ad8\u5ea6\u5bcc\u96c6\u3002EC3\u548cEC6\uff0c\u4e24\u79cd\u5728\u539f\u53d1\u6027GAC\u4e2d\u7684\u4e0d\u540c\u751f\u6001\u578b\uff0c\u4e0e\u7ec4\u7ec7\u75c5\u7406\u548c\u57fa\u56e0\u7ec4\u7279\u6027\u4ee5\u53ca\u751f\u5b58\u7ed3\u679c\u6709\u5173\u3002\u5728GAC\u8fdb\u5c55\u4e2d\u53d1\u751f\u4e86\u5e7f\u6cdb\u7684\u57fa\u8d28\u91cd\u5851\u3002\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u4e2dSDC2\u8868\u8fbe\u9ad8\u4e0e\u4fb5\u88ad\u6027\u8868\u578b\u548c\u751f\u5b58\u671f\u4e0d\u826f\u76f8\u5173\uff0cCAFs\u4e2dSDC2\u7684\u8fc7\u8868\u8fbe\u6709\u52a9\u4e8e\u80bf\u7624\u751f\u957f\u3002\u6211\u4eec\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u4e00\u4e2a\u9ad8\u5206\u8fa8\u7387\u7684GAC TME\u56fe\u8c31\uff0c\u5e76\u5f3a\u8c03\u4e86\u8fdb\u4e00\u6b65\u7814\u7a76\u7684\u6f5c\u5728\u9776\u70b9\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1b\u6162\u6027\u840e\u7f29\u6027\u80c3\u708e\uff1b\u751f\u6001\u578b\uff1b\u80c3\u817a\u764c\uff1b\u514d\u75ab-\u57fa\u8d28\u4ea4\u53c9\u5bf9\u8bdd\uff1b\u80a0\u4e0a\u76ae\u5316\u751f\uff1b\u8179\u819c\u764c\u75c5\u53d8\uff1b\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff1b\u9aa8\u9ad3\u7d202\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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09<\/strong><\/p>\n<\/section>\n<\/section>\n

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Trends Pharmacol Sci. 20230617<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u9488\u5bf9NET\u7684\u6cbb\u7597\uff1a\u6548\u679c\u3001\u9650\u5236\u4ee5\u53ca\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u7684\u53ef\u80fd\u7b56\u7565<\/strong>
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Trends Pharmacol Sci. 2023 Jul 17;S0165-6147(23)00134-7. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.tips.2023.06.007. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37468402\/<\/span><\/p>\n

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\u5173\u952e\u8bcd<\/strong><\/p>\n

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Sci Transl Med. 20230719<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Sci Transl Med. 2023 Jul 19;15(705):eadf5302. <\/em><\/p>\n

doi: <\/strong>10.1126\/scitranslmed.adf5302. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37467314\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u662f\u6700\u5177\u4fb5\u88ad\u6027\u7684\u539f\u53d1\u6027\u8111\u80bf\u7624\u7c7b\u578b\uff0c\u6025\u9700\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u764c\u7ec6\u80de\u80fd\u591f\u901a\u8fc7\u514d\u75ab\u8010\u53d7\u6027\u7a0b\u5e8f\u6765\u9003\u907f\u5982\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\u884d\u751f\u7ec6\u80de\u7b49\u541e\u566c\u7ec6\u80de\u7684\u6e05\u9664\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u53d1\u73b0\u553e\u6db2\u9178\u514d\u75ab\u7403\u86cb\u767d\u6837\u7ed3\u5408\u53d7\u4f539\uff08Siglec-9\uff09\u7684\u9ad8\u8868\u8fbe\u4e0eGBM\u60a3\u8005\u7684\u751f\u5b58\u671f\u964d\u4f4e\u76f8\u5173\u3002\u6211\u4eec\u4f7f\u7528\u4e86\u5c0f\u80f6\u8d28\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\u884d\u751f\u7ec6\u80de\u7279\u5f02\u6027\u7684Siglec-E\uff08Siglec-9\u7684\u5c0f\u9f20\u529f\u80fd\u540c\u6e90\u7269\uff09\u6572\u9664\uff0c\u5e76\u7ed3\u5408\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u6211\u4eec\u8bc1\u660e\u4e86Siglec-E\u6291\u5236\u4e86\u8fd9\u4e9b\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e86\u514d\u75ab\u9003\u9038\u3002\u5355\u6838\u7ec6\u80de\u884d\u751f\u7ec6\u80de\u4e0aSiglec-E\u7684\u4e27\u5931\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86\u6297\u539f\u4ea4\u53c9\u5448\u9012\u548c\u4fc3\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u8fd9\u5bfc\u81f4\u4e86\u66f4\u6709\u6548\u7684T\u7ec6\u80de\u542f\u52a8\u3002\u8fd9\u79cd\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u53cd\u5e94\u7684\u6865\u63a5\u5ef6\u8fdf\u4e86\u80bf\u7624\u751f\u957f\uff0c\u5e76\u5728GBM\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u5ef6\u957f\u4e86\u751f\u5b58\u671f\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u5c55\u793a\u4e86Siglec-E\u963b\u65ad\u548c\u5176\u4ed6\u514d\u75ab\u6cbb\u7597\u7684\u7ec4\u5408\u6d3b\u6027\uff0c\u8fd9\u8868\u660e\u9776\u5411Siglec-9\u53ef\u4f5c\u4e3a\u6cbb\u7597GBM\u60a3\u8005\u7684\u6f5c\u5728\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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11<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Commun. 20230717<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nat Commun. 2023 Jul 17;14(1):4251. <\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-023-39953-w.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37460545\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u6210\u7ea4\u7ef4\u7ec6\u80de\u5177\u6709\u663e\u8457\u7684\u529f\u80fd\u548c\u5206\u5b50\u5f02\u8d28\u6027\uff0c\u5e76\u53ef\u4ee5\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u53d1\u6325\u5404\u79cd\u89d2\u8272\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u4f7f\u7528\u591a\u4e2a\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6570\u636e\u96c6\uff0c\u786e\u5b9a\u4e86\u4e00\u4e2a\u4fc3\u7624\u7684IL1R1+\uff0cIL-1\u9ad8\u4fe1\u53f7\u8f6c\u5bfc\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e9a\u578b\u3002\u8fd9\u79cd\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e9a\u578b\u4e0eT\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7684\u6291\u5236\u6709\u5173\uff0c\u5e76\u57283D\u5171\u57f9\u517b\u8bd5\u9a8c\u4e2d\u5bfc\u81f4\u764c\u7ec6\u80de\u751f\u957f\u7684\u589e\u52a0\u3002\u6b64\u5916\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u7279\u5f02\u6027\u7684IL1R1\u6572\u9664\u548cIL-1\u53d7\u4f53\u62ee\u6297\u5242Anakinra\u7684\u5e94\u7528\u90fd\u51cf\u5c11\u4e86\u4f53\u5185\u7684\u80bf\u7624\u751f\u957f\u3002\u8fd9\u4f34\u968f\u7740\u80bf\u7624\u5185Th17\u7ec6\u80de\u6d78\u6da6\u7684\u51cf\u5c11\u3002\u540c\u65f6\uff0c\u8868\u8fbeIL1R1\u7684\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u7684CRC\u60a3\u8005\uff0c\u4e5f\u663e\u793a\u51fa\u514d\u75ab\u8017\u7aed\u6807\u8bb0\u7269\u7684\u6c34\u5e73\u5347\u9ad8\uff0c\u4ee5\u53caTh17\u8bc4\u5206\u7684\u589e\u52a0\u548c\u603b\u4f53\u751f\u5b58\u671f\u7684\u964d\u4f4e\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u5f3a\u8c03\u4e86\u5728CRC\u80cc\u666f\u4e0b\u9488\u5bf9\u8868\u8fbeIL1R1\u7684CAFs\u7684\u6cbb\u7597\u4ef7\u503c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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12<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Cell. 20230711<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Cancer Cell. 2023 Jul 11;S1535-6108(23)00218-0.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.06.008. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37451271\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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\u5173\u952e\u8bcd<\/strong><\/p>\n

\u6811\u7a81\u72b6\u7ec6\u80de\uff1bT\u7ec6\u80de\uff1b\u6297\u764c\u514d\u75ab\uff1b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff1b\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\uff1b\u6df1\u5ea6\u5b66\u4e60\uff1b\u514d\u75ab\u9003\u9038\uff1b\u5e72\u7ec6\u80de\u6837T\u7ec6\u80de\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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13<\/strong><\/p>\n<\/section>\n<\/section>\n

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Immunity. 20230707<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Immunity. 2023 Jul 7;S1074-7613(23)00274-1. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.immuni.2023.06.017.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37451265\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u662f\u4e00\u79cd\u9ad8\u5ea6\u81f4\u547d\u7684\u8111\u764c\uff0c\u4ee5\u514d\u75ab\u6291\u5236\u800c\u81ed\u540d\u662d\u8457\uff0c\u4f46\u5176\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u8bb0\u5f55\u4e86\u80bf\u7624\u76f8\u5173\u9ad3\u6837\u7ec6\u80de\uff08TAMs\uff09\u7684\u65f6\u7a7a\u6a21\u5f0f\uff0c\u8fd9\u4e0eGBM\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u7684\u8840\u7ba1\u53d8\u5316\u76f8\u5bf9\u5e94\u3002\u968f\u7740\u80bf\u7624\u8840\u7ba1\u4ece\u6700\u521d\u7684\u5bc6\u96c6\u6b63\u5e38\u7f51\u7edc\u8fc7\u6e21\u5230\u540e\u671f\u7684\u7a00\u758f\u548c\u5145\u8840\u8840\u7ba1\uff0cTAMs\u4ece\u8840\u7ba1\u5468\u56f4\u533a\u57df\u8f6c\u79fb\u51fa\u6765\uff0c\u79fb\u5411\u8840\u7ba1\u8d2b\u7620\u7684\u533a\u57df\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d7\u5230\u5bbf\u4e3b\u514d\u75ab\u80fd\u529b\u72b6\u6001\u7684\u5f71\u54cd\u3002\u6211\u4eec\u4f7f\u7528\u654f\u611f\u7684\u8367\u5149UnaG\u62a5\u544a\u5668\u8ffd\u8e2a\u80bf\u7624\u7f3a\u6c27\uff0c\u5e76\u7ed3\u5408\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5b66\uff0c\u6211\u4eec\u63ed\u793a\u4e86\u7f3a\u6c27\u751f\u6001\u4f4d\u5438\u5f15\u5e76\u56f0\u4f4fTAMs\u548c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTLs\uff09\uff0c\u5728\u90a3\u91cc\u5b83\u4eec\u88ab\u91cd\u65b0\u7f16\u7a0b\u5230\u514d\u75ab\u6291\u5236\u72b6\u6001\u3002\u5728\u673a\u5236\u4e0a\uff0c\u6211\u4eec\u786e\u5b9a\u4e86\u8d8b\u5316\u56e0\u5b50CCL8\u548c\u7ec6\u80de\u56e0\u5b50IL-1\u03b2\u662f\u4e24\u4e2a\u5bf9TAM\u8fc1\u79fb\u4ee5\u53ca\u7f3a\u6c27\u533a\u57df\u5411\u5047\u6805\u683c\u6a21\u5f0f\u5171\u6f14\u5316\u81f3\u5173\u91cd\u8981\u7684\u7f3a\u6c27\u751f\u6001\u4f4d\u56e0\u5b50\u3002\u56e0\u6b64\uff0c\u5e72\u6270\u7f3a\u6c27\u533a\u57df\u4e2d\u7684TAM\u6a21\u5f0f\u53ef\u80fd\u6539\u5584\u80bf\u7624\u63a7\u5236\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

CCL8\uff1bCTLs\uff1bGBM\uff1bIL-1\u03b2\uff1bTAM\uff1b\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff1b\u514d\u75ab\u666f\u89c2\uff1b\u514d\u75ab\u6291\u5236\uff1b\u80bf\u7624\u7f3a\u6c27\uff1b\u80bf\u7624\u8840\u7ba1\uff1b\u80bf\u7624\u76f8\u5173\u5fae\u80f6\u8d28\u7ec6\u80de\/\u5de8\u566c\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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14<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Cell Biol. 20230713<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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STING\u662f\u4e00\u4e2a\u7ec6\u80de\u5185\u5728\u7684\u4ee3\u8c22\u68c0\u67e5\u70b9\uff0c\u901a\u8fc7\u9776\u5411HK2\u9650\u5236\u6709\u6c27\u7cd6\u9175\u89e3<\/strong>
<\/p>\n

Nat Cell Biol. 2023 Jul 13. <\/em><\/p>\n

doi: <\/strong>10.1038\/s41556-023-01185-x. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37443289\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u9003\u907f\u6297\u80bf\u7624\u514d\u75ab\u662f\u764c\u75c7\u7684\u4e00\u4e2a\u6807\u5fd7\u3002STING\uff0c\u4e00\u79cd\u516c\u8ba4\u7684\u5929\u7136\u514d\u75ab\u4fe1\u53f7\u9002\u914d\u5668\uff0c\u5728\u901a\u8fc7\u914d\u5408\u9ad3\u7cfb\u7ec6\u80de\u7684\u5185\u6e90\u611f\u5e94\u548c\u9002\u5e94\u6027\u514d\u75ab\u76d1\u89c6\u6765\u53d1\u8d77\u6297\u80bf\u7624\u514d\u75ab\u65b9\u9762\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u5728\u5404\u79cd\u4eba\u7c7b\u6076\u6027\u80bf\u7624\u4e2d\uff0cSTING\u663e\u8457\u5730\u88ab\u6c89\u9ed8\uff0c\u5e76\u4f5c\u4e3a\u7ec6\u80de\u5185\u5728\u7684\u80bf\u7624\u6291\u5236\u56e0\u5b50\u3002STING\u5982\u4f55\u53d1\u6325\u5185\u5728\u7684\u6297\u80bf\u7624\u6d3b\u6027\u5c1a\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u53d1\u73b0STING\u53ef\u9650\u5236\u6709\u6c27\u7cd6\u9175\u89e3\uff0c\u8fd9\u72ec\u7acb\u4e8e\u5176\u5929\u7136\u514d\u75ab\u529f\u80fd\u3002\u5728\u673a\u5236\u4e0a\uff0cSTING\u9776\u5411\u5df1\u7cd6\u6fc0\u9176II\uff08HK2\uff09\u4ee5\u963b\u6b62\u5176\u5df1\u7cd6\u6fc0\u9176\u6d3b\u6027\u3002\u56e0\u6b64\uff0cSTING\u901a\u8fc7\u6291\u5236HK2\u6765\u9650\u5236\u80bf\u7624\u7684\u6709\u6c27\u7cd6\u9175\u89e3\uff0c\u5e76\u5728\u4f53\u5185\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u3002\u5728\u4eba\u7c7b\u7ed3\u76f4\u80a0\u764c\u6837\u672c\u4e2d\uff0c\u4e73\u9178\uff08\u53ef\u4ee5\u4f5c\u4e3a\u6709\u6c27\u7cd6\u9175\u89e3\u7684\u66ff\u4ee3\u54c1\uff09\u4e0eSTING\u8868\u8fbe\u6c34\u5e73\u548c\u6297\u80bf\u7624\u514d\u75ab\u5448\u8d1f\u76f8\u5173\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u63ed\u793a\u4e86STING\u4f5c\u4e3a\u4e00\u4e2a\u7ec6\u80de\u5185\u5728\u7684\u4ee3\u8c22\u68c0\u67e5\u70b9\uff0c\u9650\u5236\u6709\u6c27\u7cd6\u9175\u89e3\u4ee5\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u3002\u8fd9\u4e9b\u53d1\u73b0\u5bf9\u4e8e\u5f00\u53d1\u57fa\u4e8eSTING\u7684\u6cbb\u7597\u65b9\u6cd5\u4ee5\u6539\u5584\u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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15<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Hematol Oncol. 20230725<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u764c\u75c7\u4e2d\u7684\u4ee3\u8c22\u3001\u4ee3\u8c22\u7269\u548c\u5de8\u566c\u7ec6\u80de<\/strong>
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J Hematol Oncol. 2023 Jul 25;16(1):80. <\/em><\/p>\n

doi: <\/strong>10.1186\/s13045-023-01478-6.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37491279\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAMs\uff09\u662f\u80bf\u7624\u5fae\u73af\u5883\u7684\u5173\u952e\u6210\u5206\uff0c\u901a\u8fc7\u5f62\u6210\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\uff0c\u5728\u80bf\u7624\u53d1\u5c55\u548c\u836f\u7269\u62b5\u6297\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5de8\u566c\u7ec6\u80de\u662f\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u5bf9\u62b5\u6297\u75c5\u539f\u4f53\u548c\u8c03\u8282\u751f\u7269\u4f53\u7a33\u6001\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5de8\u566c\u7ec6\u80de\u7684\u529f\u80fd\u548c\u6781\u5316\u4e0e\u4ee3\u8c22\u6539\u53d8\u5bc6\u5207\u76f8\u5173\u3002\u901a\u5e38\uff0cM1\u578b\u5de8\u566c\u7ec6\u80de\u4e3b\u8981\u4f9d\u8d56\u6709\u6c27\u7cd6\u9175\u89e3\uff0c\u800cM2\u578b\u5de8\u566c\u7ec6\u80de\u4f9d\u8d56\u6c27\u5316\u4ee3\u8c22\u3002\u4ee3\u8c22\u7814\u7a76\u5df2\u7ecf\u63ed\u793a\u4e86\u80bf\u7624\u5fae\u73af\u5883\u4e2dTAMs\u548c\u4ee3\u8c22\u7269\u7684\u4ee3\u8c22\u7279\u5f81\u8c03\u8282\u7740TAMs\u7684\u529f\u80fd\u548c\u6781\u5316\u3002\u7136\u800c\uff0c\u4ee3\u8c22\u91cd\u7f16\u7a0b\u5bf9\u80bf\u7624\u548cTAMs\u7684\u7cbe\u786e\u6548\u5e94\u5c1a\u672a\u5b8c\u5168\u4e86\u89e3\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u4ee3\u8c22\u9014\u5f84\u5bf9\u5de8\u566c\u7ec6\u80de\u529f\u80fd\u548c\u6781\u5316\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u91cd\u65b0\u7f16\u7a0b\u5de8\u566c\u7ec6\u80de\u4ee3\u8c22\u7684\u6f5c\u5728\u7b56\u7565\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

\u764c\u75c7\uff1b\u4ee3\u8c22\uff1b\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff1b\u80bf\u7624\u5fae\u73af\u5883\uff1b\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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16<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gut. 20230725<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Roseburia intestinalis\u4ea7\u751f\u7684\u4e01\u9178\u901a\u8fc7\u6fc0\u6d3b\u7ec6\u80de\u6bd2\u6027CD8+ T\u7ec6\u80de\u4ee5\u63d0\u9ad8\u6297PD-1\u7597\u6cd5\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u6548\u679c<\/strong>
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Gut. 2023 Jul 25;gutjnl-2023-330291. <\/em><\/p>\n

doi: <\/strong>10.1136\/gutjnl-2023-330291. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37491158\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

Roseburia intestinalis\u662f\u4e00\u79cd\u76ca\u751f\u83cc\u79cd\u7c7b\uff0c\u901a\u8fc7\u4ea7\u751f\u4ee3\u8c22\u7269\u53ef\u4ee5\u6291\u5236\u80a0\u9053\u708e\u75c7\u3002\u6211\u4eec\u65e8\u5728\u7814\u7a76R. intestinalis\u5728\u7ed3\u76f4\u80a0\u80bf\u7624\u53d1\u751f\u548c\u514d\u75ab\u7597\u6cd5\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n

\u5728\u7ed3\u76f4\u80a0\u764c (CRC) \u60a3\u8005\uff08n=444\uff09\u548c\u5065\u5eb7\u5bf9\u7167\uff08n=575\uff09\u7684\u7caa\u4fbf\u4e2d\u8bc4\u4f30R. intestinalis\u7684\u4e30\u5ea6\u3002\u5728ApcMin\/+\u6216\u8005\u6c2e\u5316\u5076\u6c2e\uff08AOM\uff09\u8bf1\u5bfc\u7684CRC\u5c0f\u9f20\u6a21\u578b\uff0c\u4ee5\u53caCT26\uff08\u5fae\u536b\u661f\u7a33\u5b9a\u6027\uff08MSI\uff09-\u4f4e\uff09\u6216MC38\uff08MSI-\u9ad8\uff09\u7684\u540c\u79cd\u5f02\u4f53\u5c0f\u9f20\u79fb\u690d\u6a21\u578b\u4e2d\u7814\u7a76R. intestinalis\u7684\u6548\u679c\u3002\u901a\u8fc7\u591a\u8272\u6d41\u5f0f\u7ec6\u80de\u672f\u548c\u514d\u75ab\u7ec4\u5316\u67d3\u8272\u8bc4\u4f30\u514d\u75ab\u666f\u89c2\u7684\u53d8\u5316\u3002\u901a\u8fc7\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\u6765\u63cf\u7ed8\u4ee3\u8c22\u7269\u3002<\/p>\n

\u4e0e\u5065\u5eb7\u5bf9\u7167\u76f8\u6bd4\uff0cCRC\u60a3\u8005\u7684\u7caa\u4fbf\u4e2dR. intestinalis\u660e\u663e\u51cf\u5c11\u3002R. intestinalis\u7684\u4f7f\u7528\u663e\u8457\u6291\u5236\u4e86ApcMin\/+\u5c0f\u9f20\u7684\u80bf\u7624\u5f62\u6210\uff0c\u8fd9\u5728AOM\u8bf1\u5bfc\u7684CRC\u5c0f\u9f20\u4e2d\u5f97\u5230\u4e86\u8bc1\u5b9e\u3002R. intestinalis\u6062\u590d\u4e86\u80a0\u9053\u5c4f\u969c\u529f\u80fd\uff0c\u5982\u6539\u5584\u7684\u80a0\u9053\u901a\u900f\u6027\u548c\u589e\u5f3a\u7684\u7d27\u5bc6\u8fde\u63a5\u86cb\u767d\u7684\u8868\u8fbe\u3002\u4e01\u9178\u88ab\u786e\u5b9a\u4e3aR. intestinalis\u4ea7\u751f\u7684\u529f\u80fd\u6027\u4ee3\u8c22\u7269\u3002R. intestinalis\u6216\u4e01\u9178\u901a\u8fc7\u8bf1\u5bfc\u7ec6\u80de\u6bd2\u6027\u9897\u7c92\u9176B+\uff0c\u5e72\u6270\u7d20\uff08IFN\uff09-\u03b3+\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09-\u03b1+ CD8+ T\u7ec6\u80de\u5728MC38\u6216CT26\u7684\u539f\u4f4d\u5c0f\u9f20\u6a21\u578b\u4e2d\u6291\u5236\u80bf\u7624\u751f\u957f\u3002R. intestinalis\u6216\u4e01\u9178\u4e5f\u663e\u8457\u6539\u5584\u4e86\u643a\u5e26MSI-low CT26\u80bf\u7624\u7684\u5c0f\u9f20\u7684\u6297\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d1\uff08anti-PD-1\uff09\u7684\u6548\u679c\u3002\u5728\u673a\u5236\u4e0a\uff0c\u4e01\u9178\u76f4\u63a5\u4e0eCD8+ T\u7ec6\u80de\u4e0a\u7684Toll\u6837\u53d7\u4f535\uff08TLR5\uff09\u53d7\u4f53\u7ed3\u5408\uff0c\u901a\u8fc7\u6fc0\u6d3b\u6838\u56e0\u5b50kappa B\uff08NF-\u03baB\uff09\u4fe1\u53f7\u6765\u8bf1\u5bfc\u5176\u6d3b\u6027\u3002<\/p>\n

R. intestinalis\u901a\u8fc7\u4ea7\u751f\u4e01\u9178\u6765\u9632\u6b62\u7ed3\u76f4\u80a0\u80bf\u7624\u53d1\u751f\uff0c\u8fd9\u4e5f\u53ef\u4ee5\u901a\u8fc7\u8bf1\u5bfc\u529f\u80fd\u6027CD8+ T\u7ec6\u80de\u6765\u6539\u5584\u6297PD-1\u7684\u6548\u679c\u3002R. intestinalis\u662f\u4e00\u79cd\u53ef\u80fd\u7684\u8f85\u52a9\u5242\uff0c\u53ef\u4ee5\u589e\u5f3a\u6297PD-1\u5bf9CRC\u7684\u6548\u679c\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong>
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\u4e01\u9178\uff1b\u7ed3\u80a0\u5fae\u751f\u7269\uff1b\u7ed3\u76f4\u80a0\u764c\uff1b\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Nat Rev Clin Oncol. 20230724<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nat Rev Clin Oncol. 2023 Jul 24. <\/em><\/p>\n

doi: <\/strong>10.1038\/s41571-023-00803-9. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37488231\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u5728\u5c40\u90e8\u548c\u5168\u8eab\u8c03\u8282\u514d\u75ab\u8fc7\u7a0b\u3002\u8fd9\u5305\u62ec\u514d\u75ab\u7cfb\u7edf\u5bf9\u65b0\u51fa\u73b0\u7684\u80bf\u7624\u5982\u4f55\u4ee5\u53ca\u5982\u4f55\u53cd\u5e94\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u6cbb\u7597\u671f\u95f4\u662f\u5426\u91cd\u65b0\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u4ee5\u53ca\u6b64\u7c7b\u6cbb\u7597\u662f\u5426\u4f34\u968f\u7740\u610f\u5916\u7684\u7834\u574f\u6027\u514d\u75ab\u75c5\u7406\u3002\u8fc7\u53bb\u5341\u5e74\u7684\u8fdb\u5c55\u5df2\u7ecf\u8bc1\u660e\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u662f\u4e00\u4e2a\u6709\u5e0c\u671b\u7684\u9776\u70b9\uff0c\u8c03\u8282\u5fae\u751f\u7269\u7fa4\u53ef\u80fd\u514b\u670d\u5bf9ICI\u7684\u8010\u836f\u6027\u548c\/\u6216\u6539\u5584\u6cbb\u7597\u7684\u5b89\u5168\u6027\u3002\u7136\u800c\uff0c\u5fae\u751f\u7269\u7fa4\u8c03\u8282\u6297\u80bf\u7624\u514d\u75ab\u7684\u5177\u4f53\u673a\u5236\u4ecd\u4e0d\u6e05\u695a\u3002\u4e86\u89e3\u5fae\u751f\u7269\u7fa4\u4e0e\u63a5\u53d7ICI\u6cbb\u7597\u7684\u60a3\u8005\u4e34\u5e8a\u7ed3\u679c\u76f8\u5173\u8054\u7684\u751f\u7269\u5b66\u57fa\u7840\uff0c\u4ee5\u53ca\u201c\u5065\u5eb7\u201d\u5fae\u751f\u7269\u7fa4\u7684\u72b6\u51b5\uff0c\u5c06\u4e3a\u6709\u6548\u64cd\u7eb5\u5fae\u751f\u7269\u7fa4\u63d0\u4f9b\u91cd\u8981\u7684\u57fa\u7840\uff0c\u4ece\u800c\u6539\u5584\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u63a2\u8ba8\u4e86\u996e\u98df\u548c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u5728ICI\u6cbb\u7597\u671f\u95f4\u5851\u9020\u514d\u75ab\u53cd\u5e94\u7684\u4f5c\u7528\uff0c\u5e76\u5f3a\u8c03\u5728\u5c06\u80a0\u9053\u83cc\u7fa4\u4f5c\u4e3a\u764c\u75c7\u60a3\u8005\u4e34\u5e8a\u7ba1\u7406\u7684\u5b9e\u7528\u5de5\u5177\u65f6\u9762\u4e34\u7684\u5173\u952e\u6311\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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18<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nat Rev Clin Oncol. 20230724<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nat Rev Clin Oncol. 2023 Jul 24. <\/em><\/p>\n

doi: <\/strong>10.1038\/s41571-023-00794-7. <\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37488229\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

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RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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