{"id":5153,"date":"2023-10-03T22:13:49","date_gmt":"2023-10-03T14:13:49","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/10\/03\/monthly-updates-2023-09\/"},"modified":"2025-01-03T18:49:39","modified_gmt":"2025-01-03T10:49:39","slug":"monthly-updates-2023-09","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/10\/03\/monthly-updates-2023-09\/","title":{"rendered":"Monthly Updates 2023.09"},"content":{"rendered":"
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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20230906<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nature. 2023 Sep 6.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-06511-9.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37674079\/<\/span><\/p>\n

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02<\/strong><\/p>\n<\/section>\n<\/section>\n

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Mol Cancer. 20230907<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Mol Cancer. 2023 Sep 7;22(1):148.<\/em><\/p>\n

doi: <\/strong>10.1186\/s12943-023-01843-6.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37679744\/<\/span><\/p>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20230906<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nature. 2023 Sep 6.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-06498-3.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37674077\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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04<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Discov. 20230906<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Cancer Discov. 2023 Sep 6;13(9):1973-1981.<\/em><\/p>\n

doi: <\/strong>10.1158\/2159-8290.CD-23-0505.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37671471\/<\/span><\/p>\n

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05<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell Death Differ. 2023090<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u901a\u8fc7\u53bb\u6cdb\u7d20\u5316\u548c\u7a33\u5b9aPD-L1\uff0cUSP2\u5e2e\u52a9\u80bf\u7624\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u653b\u51fb<\/strong>
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Cell Death Differ. 2023 Sep 5.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41418-023-01219-9.
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PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37670038\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f53-1 (PD-L1)\u5f02\u5e38\u589e\u52a0\u4f1a\u963b\u6b62T\u7ec6\u80de\u901a\u8fc7PD-1\u7ed3\u5408\u6240\u4ea7\u751f\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u56e0\u6b64\uff0c\u5bf9PD-L1\u5728\u80bf\u7624\u4e2d\u7684\u8c03\u63a7\u673a\u5236\u7684\u6df1\u5165\u7814\u7a76\u53ef\u80fd\u6709\u52a9\u4e8e\u589e\u5f3aPD-L1\u963b\u65ad\u6cbb\u7597\u7684\u6548\u679c\u3002\u6211\u4eec\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u6cdb\u7d20\u7279\u5f02\u6027\u52a0\u5de5\u86cb\u767d\u91762 (USP2)\u662f\u4e00\u79cd\u65b0\u578b\u7684PD-L1\u7a33\u5b9a\u8c03\u8282\u56e0\u5b50\uff0c\u5b83\u901a\u8fc7\u53bb\u6cdb\u7d20\u5316\u589e\u52a0\u80bf\u7624\u7ec6\u80de\u4e2dPD-L1\u7684\u6570\u91cf\uff0c\u5e2e\u52a9\u80bf\u7624\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u653b\u51fb\u3002\u6211\u4eec\u7684\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0cUSP2\u901a\u8fc7\u89e3\u9664PD-L1\u7684\u805a\u6cdb\u7d20\u5316\u6765\u589e\u52a0PD-L1\u7684\u6570\u91cf\uff0c\u4ece\u800c\u4f7f\u80bf\u7624\u7ec6\u80de\u5bf9T\u7ec6\u80de\u4ecb\u5bfc\u7684\u6740\u4f24\u53d8\u5f97\u4e0d\u654f\u611f\u3002\u800cUSP2\u7684\u7f3a\u5931\u4f1a\u5bfc\u81f4PD-L1\u5728\u5185\u8d28\u7f51\u4e2d\u7684\u964d\u89e3\uff0c\u51cf\u5f31\u4e86PD-L1\u548cPD-1\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f7f\u764c\u7ec6\u80de\u5bf9T\u7ec6\u80de\u4ecb\u5bfc\u7684\u6740\u4f24\u53d8\u5f97\u66f4\u654f\u611f\u3002\u6211\u4eec\u8fd8\u53d1\u73b0\uff0cUSP2\u7684\u6d88\u9664\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0CD8+<\/sup> T\u7ec6\u80de\u7684\u6d78\u6da6\u548c\u51cf\u5c11\u514d\u75ab\u6291\u5236\u7ec6\u80de\u7684\u6d78\u6da6\uff0c\u589e\u5f3a\u5c0f\u9f20\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u589e\u52a0PD-L1\u7684\u8868\u8fbe\uff0cUSP2\u7f3a\u5931\u53ef\u4ee5\u9006\u8f6c\u80bf\u7624\u751f\u957f\u7684\u6291\u5236\u3002\u6211\u4eec\u7684\u7814\u7a76\u8fd8\u53d1\u73b0\uff0cUSP2\u7684\u6572\u9664\u548c\u6297PD-1\u7684\u8054\u5408\u6cbb\u7597\u5177\u6709\u534f\u540c\u7684\u6297\u80bf\u7624\u6548\u679c\u3002\u5bf9\u4e34\u5e8a\u6837\u672c\u7684\u5206\u6790\u4e5f\u663e\u793a\uff0cUSP2\u548cPD-L1\u5728\u764c\u75c7\u4e2d\u7684\u8868\u8fbe\u5177\u6709\u6b63\u76f8\u5173\u6027\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u7684\u7814\u7a76\u63ed\u793a\u4e86USP2\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u63a7\u5236PD-L1\u7a33\u5b9a\u6027\u7684\u5173\u952e\u4f5c\u7528\uff0c\u5e76\u7a81\u663e\u4e86USP2\u4f5c\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/strong><\/p>\n<\/section>\n<\/section>\n

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Immunity. 20230908<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6811\u7a81\u72b6\u7ec6\u80de\uff1a\u764c\u75c7T\u7ec6\u80de\u514d\u75ab\u7684\u5f15\u9886\u8005<\/strong>
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Immunity. 2023 Sep 8;S1074-7613(23)00370-9.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.immuni.2023.08.014.
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PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37708889\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u5728\u764c\u75c7\u60a3\u8005\u4e2d\uff0c\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u7684\u6811\u7a81\u72b6\u7ec6\u80de (DCs) \u626e\u6f14\u7740\u91cd\u8981\u7684\u89d2\u8272\u3002\u5b83\u4eec\u6253\u7834\u4e86\u514d\u75ab\u7cfb\u7edf\u7684\u6c89\u9ed8\uff0c\u5c06\u6297\u539f\u5448\u9012\u7ed9\u521d\u59cbT\u7ec6\u80de\uff0c\u4ece\u800c\u542f\u52a8\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u4e9b\u88ab\u542f\u52a8\u7684T\u7ec6\u80de\u4f1a\u5728\u80bf\u7624\u90e8\u4f4d\u8fdb\u4e00\u6b65\u53d7\u5230DCs\u7684\u5f71\u54cd\u3002DCs\u5728\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\u591a\u79cd\u591a\u6837\uff0c\u65e2\u53ef\u4ee5\u7ed9T\u7ec6\u80de\u63d0\u4f9b\u751f\u5b58\u7684\u4fe1\u53f7\uff0c\u4e5f\u53ef\u4ee5\u63a8\u52a8\u6548\u5e94\u7ec6\u80de\u7684\u5206\u5316\uff0c\u4ece\u800c\u5728\u5c40\u90e8\u52a0\u5f3a\u5bf9\u6297\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002\u7136\u800c\uff0c\u80bf\u7624\u4e2d\u7684DCs\u53ef\u80fd\u4f1a\u56e0\u6570\u91cf\u4e0d\u8db3\u6216\u514d\u75ab\u8c03\u8282\u5206\u5b50\u7684\u8868\u8fbe\u800c\u9650\u5236\u6297\u80bf\u7624T\u7ec6\u80de\u7684\u53cd\u5e94\u3002\u5728\u8fd9\u7bc7\u6587\u7ae0\u4e2d\uff0c\u6211\u4eec\u5c06\u56de\u987e\u76ee\u524d\u5bf9DC\u548cT\u7ec6\u80de\u5728\u514d\u75ab\u53cd\u5e94\u542f\u52a8\u548c\u6548\u5e94\u90e8\u4f4d\u76f8\u4e92\u4f5c\u7528\u7684\u7406\u89e3\u3002\u6211\u4eec\u5c06\u4eceDC\u7684\u53d1\u5c55\u3001\u8d77\u6e90\u548c\u5728\u5176\u4ed6\u73af\u5883\u4e2d\u7684\u4f5c\u7528\u51fa\u53d1\uff0c\u63a2\u8ba8\u5728\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u65b0\u53d1\u73b0\uff0c\u5e76\u63d0\u51faDC\u81f3\u5c11\u63a7\u5236\u4e24\u4e2a\u4e0eT\u7ec6\u80de\u76f8\u5173\u7684\u80bf\u7624\u514d\u75ab\u5468\u671f\u68c0\u67e5\u70b9\u3002\u5bf9\u8fd9\u4e24\u4e2a\u68c0\u67e5\u70b9\u7684\u7406\u89e3\u5bf9\u4e8e\u5f00\u53d1\u65b0\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u5177\u6709\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/strong><\/p>\n<\/section>\n<\/section>\n

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Immunity. 20230903<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u9488\u5bf9\u56fa\u6709\u514d\u75ab\u901a\u8def\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597<\/strong>
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Immunity. 2023 Sep 3;S1074-7613(23)00331-X.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.immuni.2023.07.018.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37703879\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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08<\/strong><\/p>\n<\/section>\n<\/section>\n

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Nature. 20230920<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Nature. 2023 Sep 20.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-06568-6.
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PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37731001\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

CD8+<\/sup> T\u7ec6\u80de\u662f\u6211\u4eec\u62b5\u6297\u75c5\u6bd2\u548c\u80bf\u7624\u7684\u91cd\u8981\u6b66\u5668\uff0c\u5b83\u4eec\u80fd\u591f\u6e05\u9664\u611f\u67d3\u7684\u7ec6\u80de\u548c\u764c\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5982\u679c\u6297\u539f\u65e0\u6cd5\u5b8c\u5168\u6e05\u9664\uff0cT\u7ec6\u80de\u4f1a\u9677\u5165\u4e00\u79cd\u88ab\u79f0\u4e3a”\u8017\u7aed”\u7684\u72b6\u6001\u3002\u8fd9\u79cd\u72b6\u6001\u4e0b\uff0c\u867d\u7136\u957f\u671f\u5b58\u5728\u7684\u6297\u539f\u4f1a\u52a0\u901fCD8+<\/sup> T\u7ec6\u80de\u7684\u8017\u7aed\uff0c\u4f46\u7ec4\u7ec7\u5185\u7684\u5e94\u6fc0\u53cd\u5e94\u662f\u5982\u4f55\u5f71\u54cdT\u7ec6\u80de\u529f\u80fd\u7684\u8fd8\u4e0d\u5341\u5206\u660e\u786e\u3002\u6211\u4eec\u7684\u7814\u7a76\u63ed\u793a\u4e86\u03b21<\/sub>\u80be\u4e0a\u817a\u7d20\u80fd\u53d7\u4f53ADRB1\u5728\u5e94\u6fc0\u53cd\u5e94\u76f8\u5173\u7684\u513f\u8336\u915a\u80fa\u548cT\u7ec6\u80de\u8017\u7aed\u4e4b\u95f4\u7684\u65b0\u8fde\u63a5\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u8017\u7aed\u7684CD8+<\/sup> T\u7ec6\u80de\u5728ADRB1\u7684\u8868\u8fbe\u4e0a\u6709\u6240\u589e\u52a0\uff0c\u800c\u66b4\u9732\u5728\u513f\u8336\u915a\u80fa\u4e2d\u7684ADRB1+<\/sup> T\u7ec6\u80de\u4f1a\u6291\u5236\u5176\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u548c\u589e\u6b96\u3002\u8fd9\u4e9b\u8017\u7aed\u7684CD8+<\/sup> T\u7ec6\u80de\u4f1a\u4f9d\u8d56ADRB1\u7684\u65b9\u5f0f\u805a\u96c6\u5728\u4ea4\u611f\u795e\u7ecf\u5468\u56f4\u3002\u5728\u9ed1\u8272\u7d20\u7624\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0\u6d88\u9664\u03b21<\/sub>\u80be\u4e0a\u817a\u7d20\u80fd\u4fe1\u53f7\u4f20\u5bfc\u80fd\u591f\u963b\u6b62T\u7ec6\u80de\u8fdb\u4e00\u6b65\u8017\u7aed\uff0c\u5e76\u5728\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad(ICB)\u6cbb\u7597\u65f6\u63d0\u9ad8\u6548\u679c\u3002\u5bf9\u4e8e\u90a3\u4e9b\u5bf9ICB\u6cbb\u7597\u62b5\u6297\u7684\u80f0\u817a\u764c\u6a21\u578b\uff0c\u03b2\u53d7\u4f53\u963b\u6ede\u5242\u548cICB\u80fd\u591f\u5171\u540c\u6fc0\u53d1CD8+<\/sup> T\u7ec6\u80de\u7684\u53cd\u5e94\uff0c\u5e76\u8bf1\u5bfc\u7ec4\u7ec7\u9a7b\u7559\u8bb0\u5fc6\u6837T\u7ec6\u80de\u7684\u53d1\u5c55\u3002\u6211\u4eec\u7684\u7814\u7a76\u4e3a\u7406\u89e3\u4ea4\u611f\u5e94\u6fc0\u53cd\u5e94\u3001\u7ec4\u7ec7\u795e\u7ecf\u652f\u914d\u548cT\u7ec6\u80de\u8017\u7aed\u4e4b\u95f4\u7684\u5173\u7cfb\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002\u6211\u4eec\u63ed\u793a\u4e86\u4e00\u4e2a\u65b0\u7684\u673a\u5236\uff0c\u901a\u8fc7\u963b\u65adCD8+<\/sup> T\u7ec6\u80de\u7684\u03b2-\u80be\u4e0a\u817a\u7d20\u80fd\u4fe1\u53f7\u901a\u8def\u4ee5\u6062\u590d\u5176\u6297\u80bf\u7624\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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09<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gut. 20230928<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u9e21\u4e73\u6746\u83cc\u4ee3\u8c22\u4ea7\u7269\u901a\u8fc7IDO1\/Kyn\/AHR\u8f74\u6291\u5236\u8c03\u8282\u6027T\u7ec6\u80de\uff0c\u589e\u5f3a\u6297PD-1\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u7597\u6548<\/strong>
<\/p>\n

Gut. 2023 Sep 28;gutjnl-2023-329543.<\/em><\/p>\n

doi: <\/strong>10.1136\/gutjnl-2023-329543.
<\/em><\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37770127\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u80a0\u9053\u83cc\u7fa4\u662f\u5f71\u54cd\u514d\u75ab\u6cbb\u7597\u6548\u679c\u7684\u5173\u952e\u56e0\u7d20\u3002\u8be5\u7814\u7a76\u65e8\u5728\u63a2\u7d22\u76ca\u751f\u83cc\u9e21\u4e73\u6746\u83cc\u5982\u4f55\u8c03\u8282\u514d\u75ab\u53cd\u5e94\uff0c\u5e76\u63d0\u9ad8\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u86cb\u767d1 (PD-1)\u5bf9\u7ed3\u76f4\u80a0\u764c(CRC)\u7684\u6cbb\u7597\u6548\u679c\u3002\u6211\u4eec\u5728\u4e0d\u540c\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u8bc4\u4f30\u4e86\u9e21\u4e73\u6746\u83cc\u5728\u6297PD-1\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u3002\u6211\u4eec\u4f7f\u7528\u4e86\u591a\u8272\u6d41\u5f0f\u7ec6\u80de\u672f\u6765\u8bc6\u522b\u514d\u75ab\u683c\u5c40\u7684\u53d8\u5316\uff0c\u5e76\u901a\u8fc7\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u548c\u4f53\u5916\u529f\u80fd\u5206\u6790\u8fdb\u884c\u9a8c\u8bc1\u3002\u6211\u4eec\u8fd8\u4f7f\u7528\u6db2\u76f8\u8272\u8c31-\u8d28\u8c31\u8054\u7528\u6280\u672f\u6765\u8bc6\u522b\u4ee3\u8c22\u4ea7\u7269\u3002\u6211\u4eec\u53d1\u73b0\u9e21\u4e73\u6746\u83cc\u663e\u8457\u63d0\u9ad8\u4e86\u6297PD-1\u7684\u7597\u6548\u3002\u8fd9\u79cd\u6548\u5e94\u662f\u901a\u8fc7\u51cf\u5c11\u80bf\u7624\u5185Foxp3+<\/sup> CD25+<\/sup>\u8c03\u8282\u6027T\u7ec6\u80de(Treg)\u7684\u6d78\u6da6\uff0c\u589e\u5f3aCD8+<\/sup> T\u7ec6\u80de\u7684\u6548\u5e94\u529f\u80fd\uff0c\u4ece\u800c\u589e\u5f3a\u6297PD-1\u6cbb\u7597\u7684\u6548\u679c\u3002\u6211\u4eec\u9274\u5b9a\u51fa\u9e21\u4e73\u6746\u83cc\u4ea7\u751f\u7684\u4e00\u79cd\u7279\u5b9a\u4ee3\u8c22\u7269-\u5432\u54da-3-\u7fa7\u9178(ICA)\uff0c\u5176\u53ef\u4ee5\u901a\u8fc7IDO1\/Kyn\/AHR\u8f74\u8c03\u8282Treg\u7684\u529f\u80fd\u3002\u8fd9\u4e2a\u53d1\u73b0\u63ed\u793a\u4e86\u80a0\u9053\u83cc\u7fa4\u5982\u4f55\u901a\u8fc7\u7279\u5b9a\u7684\u83cc\u7fa4\u4ee3\u8c22\u4ea7\u7269\u6765\u8c03\u8282\u5bbf\u4e3b\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8fdb\u4e00\u6b65\u5730\uff0c\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u652f\u6301\u4e86\u5728\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u4e2d\u4f7f\u7528\u9e21\u4e73\u6746\u83cc\u4f5c\u4e3a\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u3002\u9e21\u4e73\u6746\u83cc\u7684\u4ee3\u8c22\u4ea7\u7269\u53ef\u80fd\u4f5c\u4e3a\u65b0\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u901a\u8fc7\u8c03\u8282\u5fae\u751f\u7269\u7fa4\u4f53\u6765\u63d0\u9ad8\u6297PD-1\u6cbb\u7597\u7684\u6548\u679c\u3002\u8fd9\u9879\u7814\u7a76\u4e3a\u6211\u4eec\u7406\u89e3\u80a0\u9053\u83cc\u7fa4\u5982\u4f55\u5f71\u54cd\u514d\u75ab\u6cbb\u7597\uff0c\u7279\u522b\u662f\u5728\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\uff0c\u63d0\u4f9b\u4e86\u65b0\u7684\u89c1\u89e3\u3002\u6211\u4eec\u7684\u53d1\u73b0\u4e5f\u4e3a\u5f00\u53d1\u65b0\u7684\u7597\u6cd5\uff0c\u4ee5\u6539\u5584\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u9884\u540e\u63d0\u4f9b\u4e86\u53ef\u80fd\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230923<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4eba\u8111\u80bf\u7624\u5fae\u73af\u5883\u5f71\u54cd\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u6d3b\u6027<\/strong>
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Cell. 2023 Sep 23;S0092-8674(23)00977-7.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.08.043.
<\/em><\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37769657\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u4e2d\u6027\u7c92\u7ec6\u80de\u662f\u8840\u6db2\u4e2d\u6570\u91cf\u4f17\u591a\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u5b83\u4eec\u5e38\u88ab\u53d1\u73b0\u5728\u5404\u79cd\u7c7b\u578b\u7684\u80bf\u7624\u4e2d\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u764c\u75c7\uff0c\u5305\u62ec\u8111\u90e8\u80bf\u7624\u4e2d\u7684\u5177\u4f53\u4f5c\u7528\uff0c\u6211\u4eec\u4ecd\u7136\u4e0d\u5b8c\u5168\u4e86\u89e3\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5bf9\u80f6\u8d28\u7624\u548c\u8111\u8f6c\u79fb\u60a3\u8005\u7684\u80bf\u7624\u7ec4\u7ec7\u4ee5\u53ca\u76f8\u5e94\u7684\u5916\u5468\u8840\u6db2\u4e2d\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u5e76\u9996\u6b21\u8be6\u7ec6\u63cf\u8ff0\u4e86\u8fd9\u4e9b\u7ec6\u80de\u5728\u8fd9\u4e9b\u7ec4\u7ec7\u4e2d\u7684\u7279\u6027\u548c\u529f\u80fd\u3002\u901a\u8fc7\u5728\u4eba\u7c7b\u548c\u5c0f\u9f20\u4e2d\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u6211\u4eec\u53d1\u73b0\u8111\u80bf\u7624\u76f8\u5173\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\uff08TANs\uff09\u4e0e\u8840\u6db2\u4e2d\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u6709\u663e\u8457\u7684\u5dee\u5f02\uff0c\u5b83\u4eec\u7684\u751f\u547d\u671f\u66f4\u957f\uff0c\u80fd\u6291\u5236\u514d\u75ab\u53cd\u5e94\u5e76\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u3002TANs\u5448\u73b0\u51fa\u72ec\u7279\u7684\u708e\u75c7\u7279\u5f81\uff0c\u7531\u5305\u62ec\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1(TNF-\u03b1)\u548c\u94dc\u84dd\u86cb\u767d\u7b49\u53ef\u6eb6\u6027\u708e\u75c7\u4ecb\u8d28\u6240\u9a71\u52a8\uff0c\u8fd9\u5728\u8111\u8f6c\u79fb\u7624TANs\u4e2d\u5c24\u5176\u660e\u663e\u3002\u4f4d\u4e8e\u708e\u75c7\u4ecb\u8d28\u7f51\u7edc\u6838\u5fc3\u7684\u9ad3\u7cfb\u7ec6\u80de\uff08\u5305\u62ec\u80bf\u7624\u76f8\u5173\u7684\u5de8\u566c\u7ec6\u80de\uff09\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u8fd9\u6837\u4e00\u4e2a\u89c2\u70b9\uff1a\u5728\u4eba\u8111\u80bf\u7624\u4e2d\uff0c\u5173\u952e\u7684\u9ad3\u7cfb\u5fae\u73af\u5883\u5728\u8c03\u8282\u603b\u4f53\u514d\u75ab\u6291\u5236\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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11<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cancer Discov. 20230927<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e73\u817a\u764c\u80ba\u8f6c\u79fb\u7684\u65f6\u7a7a\u7279\u5f81\u786e\u5b9aTREM2\u5de8\u566c\u7ec6\u80de\u662f\u8f6c\u79fb\u8fb9\u754c\u7684\u8c03\u8282\u56e0\u5b50<\/strong>
<\/p>\n

Cancer Discov. 2023 Sep 27.<\/em><\/p>\n

doi: <\/strong>10.1158\/2159-8290.CD-23-0299.
<\/em><\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37756565\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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\u2014 THE  END \u2014<\/span><\/section>\n
\u516c\u4f17\u53f7\u53d1\u9001202309\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/section>\n
\u7b5b\u9009\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n


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SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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