{"id":5166,"date":"2023-08-28T17:13:52","date_gmt":"2023-08-28T09:13:52","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/28\/nat-immunol-20230719%ef%bc%9a%e8%82%bf%e7%98%a4%e6%96%b0%e6%8a%97%e5%8e%9f%e7%89%b9%e5%bc%82%e6%80%a7cd4-t%e7%bb%86%e8%83%9e%e6%98%af%e4%b8%aa%e5%a5%bd%e5%b8%ae%e6%89%8b\/"},"modified":"2023-08-28T17:13:52","modified_gmt":"2023-08-28T09:13:52","slug":"nat-immunol-20230719%ef%bc%9a%e8%82%bf%e7%98%a4%e6%96%b0%e6%8a%97%e5%8e%9f%e7%89%b9%e5%bc%82%e6%80%a7cd4-t%e7%bb%86%e8%83%9e%e6%98%af%e4%b8%aa%e5%a5%bd%e5%b8%ae%e6%89%8b","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/28\/nat-immunol-20230719%ef%bc%9a%e8%82%bf%e7%98%a4%e6%96%b0%e6%8a%97%e5%8e%9f%e7%89%b9%e5%bc%82%e6%80%a7cd4-t%e7%bb%86%e8%83%9e%e6%98%af%e4%b8%aa%e5%a5%bd%e5%b8%ae%e6%89%8b\/","title":{"rendered":"Nat Immunol. 20230719\uff1a\u80bf\u7624\u65b0\u6297\u539f\u7279\u5f02\u6027CD4+ T\u7ec6\u80de\u662f\u4e2a\u597d\u5e2e\u624b"},"content":{"rendered":"
\n
\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n

CD4+<\/sup> T \u7ec6\u80de\u5728\u6297\u764c\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u89d2\u8272\u5df2\u5f97\u5230\u5e7f\u6cdb\u786e\u8ba4\uff0c\u7136\u800c\u5176\u5177\u4f53\u7684\u4f5c\u7528\u673a\u5236\u4ee5\u53ca\u5f71\u54cd\u5176\u529f\u80fd\u7684\u56e0\u7d20\u4ecd\u5f85\u660e\u786e\u3002\u5728\u4e4b\u524d\u5bf9\u5c0f\u9f20\u7684\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u786e\u8ba4\u4e86\u7279\u5f02\u6027 CD4+<\/sup> T \u7ec6\u80de\u5bf9\u4e8e MHC-II \u7f3a\u9677\u578b\u9cde\u72b6\u7ec6\u80de\u764c\u80bf\u7624\u6a21\u578b\uff08SCC VII\uff09\u4e2d\u8868\u8fbe\u7684\u65b0\u6297\u539f\u9776\u6807 CLTCH129 > Q \u7684\u53cd\u5e94\u3002\u4e3a\u4e86\u6df1\u5316\u8fd9\u4e00\u7814\u7a76\uff0cBrightman \u7b49\u4eba\u8fd1\u671f\u8bc6\u522b\u51fa\u56db\u79cd\u4e0d\u540c\u7684 TCR \u514b\u9686\u578b\uff0c\u8fd9\u4e9b\u514b\u9686\u578b\u53ef\u4ee5\u4ee5\u4e0d\u540c\u7684\u4eb2\u548c\u529b\u8bc6\u522b\u8be5\u6297\u539f\u9776\u6807\uff0c\u5e76\u5bf9 CLTCH129 > Q \u7279\u5f02\u6027 CD4+<\/sup> T \u7ec6\u80de\u5728\u589e\u5f3a\u6297\u764c\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u6f5c\u529b\u8fdb\u884c\u4e86\u8bc4\u4f30\u548c\u4f18\u5316\u3002\u8fd9\u4e00\u7814\u7a76\u6210\u679c\u5df2\u5728\u300aNature Immunology\u300b\u671f\u520a\u4e2d\u53d1\u8868\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9996\u5148\uff0cBrightman\u7b49\u4eba\u4f7f\u7528\u5c0f\u9f20\u63a5\u79cd\u8f90\u7167\u7684SCC VII\u7ec6\u80de\u548c\u4f50\u5242polyI:C\uff0c\u5e76\u4fdd\u62a4\u5176\u514d\u53d7SCC VII\u6d3b\u80bf\u7624\u653b\u51fb\uff0c\u4ee5\u5206\u79bb\u6269\u5927\u7684CLTCH129> Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u6c60\u3002\u63a5\u4e0b\u6765\uff0c\u4ed6\u4eec\u4ece\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u8bc6\u522b\u548c\u9a8c\u8bc1\u4e86\u56db\u79cd\u4e0d\u540c\u7684 TCR \u514b\u9686\u578b\uff0c\u7531\u4e09\u79cd TCR \u03b2 \u514b\u9686\u578b\u548c\u56db\u79cd \u03b1 \u94fe\u514b\u9686\u578b\u7ec4\u6210\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cTCR 1 \u548c TCR 2 \u5171\u4eab\u76f8\u540c\u7684 TCR \u03b2 \u94fe\uff0c\u5e76\u4e14\u4ed6\u4eec\u7684 \u03b1 \u94fe\u4e5f\u51e0\u4e4e\u76f8\u540c\uff0c\u53ea\u6709\u4e00\u4e2a\u6c28\u57fa\u9178\u7684\u5dee\u5f02\u3002\u53e6\u5916\uff0c\u5c3d\u7ba1\u4e0e\u5148\u524d\u5728 CD8+<\/sup> T \u7ec6\u80de\u4e2d\u7684\u89c2\u5bdf\u7ed3\u679c\u4e0d\u540c\uff0cTCR 1 \u548c TCR 2 \u7684\u6d3b\u6027\u660e\u663e\u9ad8\u4e8e TCR 3 \u548c TCR 4\uff08\u7ea6\u9ad8\u51fa10\u500d\uff09\uff0c\u5e76\u4e14\u8fd9\u4e00\u73b0\u8c61\u5e76\u672a\u4e0e TCR \u7684\u8fd1\u7aef\u4fe1\u53f7\u4f20\u5bfc\u5dee\u5f02\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e3a\u4e86\u7814\u7a76 CLTCH129 > Q \u7279\u5f02\u6027 CD4+<\/sup> T \u7ec6\u80de\u5728\u4f53\u5185\u7684\u6269\u589e\u548c\u6d3b\u5316\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u76f8\u540c\u6570\u91cf\u7684\u9006\u8f6c\u5f55\u75c5\u6bd2\u8f6c\u67d3\u6807\u8bb0\u8868\u8fbe \u7684TCR 1\u6216 TCR 3\u7684 CD4+<\/sup> T \u7ec6\u80de\u8f6c\u79fb\u5230\u5e7c\u7a1a\u5c0f\u9f20\u4e2d\u3002\u5f53\u968f\u540e\u7528 SCC VII \u653b\u51fb\u5c0f\u9f20\u65f6\uff0c\u4e24\u4e2a\u4e9a\u7fa4\u90fd\u5bf9\u6297\u539f\u8bc6\u522b\u4f5c\u51fa\u53cd\u5e94\uff0c\u4e24\u4e2a\u4e9a\u7fa4\u5747\u53d1\u751f\u6269\u589e\uff0c\u8868\u8fbe\u76f8\u4f3c\u6c34\u5e73\u7684\u6025\u6027\u6fc0\u6d3b\u6807\u5fd7\u7269 CD69\uff0c\u5e76\u4ee5\u76f8\u4f3c\u7684\u7a0b\u5ea6\u4e0a\u8c03 PD-1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5373\u4f7f\u5728\u708e\u75c7\u6761\u4ef6\u4e0b\uff0cSCC VII\u4e5f\u4e0d\u8868\u8fbeMHC-II\uff0c\u8868\u8fbeTCR 1\u7684\u6d3b\u5316CD4+<\/sup> T\u7ec6\u80de\u8fc7\u7ee7\u8f6c\u79fb\u57281\u5929\u540e\u4fdd\u62a4\u5c0f\u9f20\u514d\u53d7\u80bf\u7624\u653b\u51fb\u3002\u8fd9\u79cd\u4fdd\u62a4\u662f\u6297\u539f\u7279\u5f02\u6027\u7684\uff0c\u56e0\u4e3a\u5f53\u5c0f\u9f20\u88ab\u6fc0\u6d3b\u7684\u591a\u514b\u9686\u975e\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u5904\u7406\u65f6\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u540c\u6837\u7684\u4fdd\u62a4\u3002\u5728\u7b2c\u4e00\u6b21\u653b\u51fb\u4e2d\u88ab\u4fdd\u62a4\u7684\u5c0f\u9f20\u5728\u7b2c30\u5929\u4e5f\u88ab\u4fdd\u62a4\u514d\u53d7\u518d\u6b21\u653b\u51fb\uff0c\u8fd9\u8868\u660eCLTCH129>Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u4ecb\u5bfc\u6301\u4e45\u7684\u514d\u75ab\u8bb0\u5fc6\u3002\u8fd9\u4e9b\u7ed3\u679c\u53d6\u51b3\u4e8e\u8f6c\u79fb\u7684\u7ec6\u80de\u6570\u91cf\uff0c\u56e0\u4e3a\u4e0e\u63a5\u53d7\u8f83\u9ad8\u7ec6\u80de\u5242\u91cf\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u63a5\u53d7\u8f83\u4f4e\u7ec6\u80de\u5242\u91cf\u7684\u5c0f\u9f20\u7684\u751f\u5b58\u76ca\u5904\u964d\u4f4e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9274\u4e8eCLTCH129>Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u7531\u4e8eSCC – VII\u80bf\u7624\u7ec6\u80de\u7f3a\u4e4fMHC-II\u800c\u4e0d\u80fd\u76f4\u63a5\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u4e0a\u7684\u65b0\u6297\u539f\uff0c\u7814\u7a76\u4eba\u5458\u5047\u8bbe\u89c2\u5bdf\u5230\u7684\u6297\u80bf\u7624\u4f5c\u7528\u53ef\u80fd\u662f\u901a\u8fc7CD8+<\/sup> T\u7ec6\u80de\u7684\u5e2e\u52a9\u4ecb\u5bfc\u7684\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728\u65b0\u6297\u539f\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u8fc7\u7ee7\u8f6c\u79fb\u4e4b\u524d\uff0cCD8+<\/sup> T\u7ec6\u80de\u7684\u6e05\u9664\u4f7f\u5176\u4fdd\u62a4\u4f5c\u7528\u5931\u6548\u3002\u57fa\u4e8e\u6700\u8fd1\u7684\u8bc1\u636e\uff0cCD4+<\/sup> T\u7ec6\u80de\u901a\u8fc7CD40L\u4f9d\u8d56\u7684cDC1s\u8bb8\u53ef\u63d0\u4f9b\u5e2e\u52a9\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86\u8868\u8fbeTCR 1\u7684CD4+<\/sup> T\u7ec6\u80de\u5bf9CD40L\u8868\u8fbe\u7684\u5f71\u54cd\uff0c\u53d1\u73b0\u5728\u4f53\u5916\u813e\u7ec6\u80de\u8bc6\u522b\u80bd\u6bb5\u65f6\u4e0a\u8c03\u3002\u5728\u4f53\u5185\uff0c\u5728\u80bf\u7624\u690d\u5165\u5f53\u5929\u548c2\u5929\u540e\u518d\u6b21\u7ed9\u4e88cd40l\u963b\u65ad\u6297\u4f53\uff0c\u6d88\u9664\u4e86\u65b0\u6297\u539f\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u8bf1\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u3002\u540c\u6837\uff0cTCR1\u548cTCR3\u4e4b\u95f4\u6ca1\u6709\u5dee\u5f02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u63a5\u4e0b\u6765\uff0cBrightman\u7b49\u4eba\u7814\u7a76\u4e86CLTCH129>Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u5bf9\u5df2\u7ecf\u5f62\u6210\u7684\u8f83\u5927\u80bf\u7624\u7684\u6f5c\u5728\u7597\u6548\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u65b0\u6297\u539f\u7279\u5f02\u6027\u7684CD4+<\/sup> T\u7ec6\u80de\u5728tdLNs\u4e2d\u589e\u6b96\u5e76\u6d78\u6da6\u80bf\u7624\uff0c\u4f46\u672a\u80fd\u63d0\u9ad8\u751f\u5b58\u7387\u3002\u4e3a\u4e86\u63d0\u9ad8\u5b83\u4eec\u7684\u6548\u529b\uff0c\u7814\u7a76\u4eba\u5458\u5c1d\u8bd5\u5728\u8f6c\u79fb\u524d\u5728IL-15\u548cIL-7\u4e2d\u57f9\u517b\u7ec6\u80de\uff0c\u800c\u4e0d\u662f\u5728\u6807\u51c6\u7684IL-2\u4e2d\u57f9\u517b\u7ec6\u80de\uff0c\u56e0\u4e3a\u5728CD8+<\/sup> T\u7ec6\u80de\u7684\u7814\u7a76\u4e2d\uff0c\u8fd9\u79cd\u7b56\u7565\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u8bf1\u5bfc\u5206\u5316\u7a0b\u5ea6\u8f83\u4f4e\u7684\u5e72\u7ec6\u80de\u8bb0\u5fc6\u6837\u72b6\u6001\uff0c\u5e76\u589e\u5f3aACT\u3002\u4e0eIL-2\u57f9\u517b\u7684\u7ec6\u80de\u76f8\u6bd4\uff0cIL-15\/IL-7\u57f9\u517b\u7684CLTCH129>Q -\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u5728\u5916\u5468\u8840\u4e2d\u6709\u66f4\u5927\u7684\u6269\u589e\uff0c\u5728\u80bf\u7624\u548ctdLNs\u4e2d\u79ef\u7d2f\uff0c\u5e76\u6709\u6548\u5730\u5ef6\u7f13\u80bf\u7624\u751f\u957f\u548c\u63d0\u9ad8\u751f\u5b58\u7387\u3002\u8868\u8fbeTCR 1\u548cTCR 3\u7684CD4+<\/sup> T\u7ec6\u80de\u4e4b\u95f4\u7684\u7ed3\u679c\u76f8\u4f3c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u901a\u8fc7\u5bf9\u4e0d\u540c\u4f4d\u7f6eCLTCH129>Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0tdLNs\u4e2d\u7684\u7ec6\u80de\u5dee\u5f02\u8868\u8fbe\u4e86\u8bb0\u5fc6T\u7ec6\u80de\u6807\u8bb0\u7269\uff0c\u800c\u80bf\u7624\u4e2d\u7684\u7ec6\u80de\u5dee\u5f02\u8868\u8fbe\u4e86\u4e0e\u6548\u5e94\u529f\u80fd\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u5305\u62ecTH1\u7ec6\u80de\u56e0\u5b50\u3001TCR\u4fe1\u53f7\u901a\u8def\u6210\u5206\u548c\u7ec6\u80de\u6bd2\u6027\u57fa\u56e0\u3002\u4e0e\u6b64\u76f8\u4e00\u81f4\u7684\u662f\uff0c\u6d41\u5f0f\u7ec6\u80de\u672f\u663e\u793a\uff0c\u80bf\u7624\u7ec6\u80de\u7fa4\u4e3b\u8981\u5305\u542b\u6548\u5e94\u8bb0\u5fc6T\u7ec6\u80de\uff0c\u800ctdLNs\u5305\u542b\u5404\u79cd\u8bb0\u5fc6\u4e9a\u7fa4\uff0c\u5305\u62ec\u6548\u5e94\u8bb0\u5fc6\u3001\u4e2d\u592e\u8bb0\u5fc6\u548c\u5e72\u7ec6\u80de\u8bb0\u5fc6\u6837\u7ec6\u80de\u7fa4\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5f53\u7ec6\u80de\u5728IL-15\/IL-7\u4e2d\u57f9\u517b\u65f6\uff0c\u89c2\u5bdf\u5230\u72ec\u7279\u7684\u8bb0\u5fc6\u7fa4\u4f53\uff0c\u800c\u5f53\u7ec6\u80de\u5728IL-2\u4e2d\u57f9\u517b\u65f6\u5219\u6ca1\u6709\u89c2\u5bdf\u5230\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u6dcb\u5df4\u7ed3\u4f5c\u4e3a\u8f6c\u79fb\u7684TSCM\u7ec6\u80de\u7684\u50a8\u5b58\u5e93\uff0c\u4ea7\u751f\u66f4\u591a\u5206\u5316\u7684\u4e9a\u7fa4\uff0c\u8fd0\u8f93\u5230\u80bf\u7624\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e3a\u4e86\u8bc4\u4f30\u6cbb\u7597\u6027\u8f6c\u79fb\u7684CLTCH129>Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de(\u5728IL-15\/IL-7\u4e2d\u57f9\u517b)\u5bf9CD8+<\/sup> T\u7ec6\u80de\u514d\u75ab\u7684\u5f71\u54cd\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u6d4b\u4e86PD-1\u7684\u8868\u8fbe\u3002\u867d\u7136\u80bf\u7624\u4e2d\u8868\u8fbePD-1\u7684\u5bbf\u4e3bCD8+<\/sup> T\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u6ca1\u6709\u53d8\u5316\uff0c\u4f46PD-1\u7684\u6c34\u5e73\u8f83\u4f4e\uff0c\u8868\u660e\u7ec8\u672b\u8870\u7aed\u51cf\u5c11\u3002\u5728tdLNs\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0PD-1+<\/sup>CD8+<\/sup> T\u7ec6\u80de\u663e\u8457\u589e\u52a0\uff0c\u8fd9\u4e0e\u8f6c\u79fb\u7684\u7ec6\u80de\u6570\u91cf\u76f8\u5173\uff0c\u8868\u660e\u6fc0\u6d3b\u589e\u52a0\u3002\u5f53\u5c06CLTCH129>Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u8f6c\u79fb\u5230CD8+<\/sup> T\u7ec6\u80de\u6e05\u9664\u4e86\u7684\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u65f6\uff0c\u89c2\u5bdf\u5230\u4e00\u4e9b\u521d\u6b65\u7684\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u4f46\u5931\u53bb\u4e86\u8f83\u957f\u671f\u7684\u80bf\u7624\u751f\u957f\u5ef6\u8fdf\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u65b0\u6297\u539f\u7279\u5f02\u6027\u7684TSCM\u6837CD4+<\/sup> T\u7ec6\u80de\u79ef\u6781\u53c2\u4e0e\u4e86tdLNs\u4e2d\u80bf\u7624\u7279\u5f02\u6027CD8+<\/sup> T\u7ec6\u80de\u7684\u542f\u52a8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u603b\u4e4b\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8868\u660eCLTCH129>Q\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u901a\u8fc7CD40L\u8bf1\u5bfc\u5bf9SCC VII\u7684\u6297\u80bf\u7624\u514d\u75ab\uff0c\u4ece\u800c\u589e\u5f3aCD8+<\/sup> T\u7ec6\u80de\u7684\u542f\u52a8\u3002\u65e0\u8bbaTCR\u7684\u5bc6\u5ea6\u5982\u4f55\uff0c\u6297\u80bf\u7624\u4f5c\u7528\u90fd\u662f\u660e\u663e\u7684\uff0c\u5e76\u4e14\u53ef\u4ee5\u901a\u8fc7\u5728IL-15\/IL-7\u6df7\u5408\u7269\u4e2d\u57f9\u517b\u5de5\u7a0b\u5316\u7684\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6765\u589e\u5f3a\uff0c\u4ece\u800c\u8bf1\u5bfc\u5e72\u7ec6\u80de\u8bb0\u5fc6\u6837\u8868\u578b\uff0c\u4ece\u800c\u589e\u5f3a\u4f53\u5185T\u7ec6\u80de\u7684\u6269\u589e\u5e76\u8bf1\u5bfc\u6301\u4e45\u7684\u80bf\u7624\u63a7\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n

\u4f5c\u8005\u9762\u5bf9\u9762<\/strong><\/p>\n<\/section>\n

\n
\n
\n

\u8fd9\u5468\uff0c\u7b2c\u4e00\u4f5c\u8005Spencer Brightman\u548c\u4e3b\u8981\u4f5c\u8005Stephen Schoenberger\u56de\u7b54\u4e86\u6211\u4eec\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u5bf9\u4f60\u6765\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u6700\u4ee4\u4eba\u60ca\u8bb6\u7684\u53d1\u73b0\u662f\u4ec0\u4e48?<\/strong><\/p>\n

\n
\n
\n

SB: <\/strong>\u6211\u4eec\u60ca\u8bb6\u5730\u53d1\u73b0\uff0c\u8868\u8fbe\u5177\u6709\u9002\u5ea6\u4eb2\u548c\u529b\u7684T\u7ec6\u80de\u53d7\u4f53\u7684CD4+<\/sup> T\u7ec6\u80de\uff0c\u5176\u529f\u80fd\u4e0e\u8868\u8fbe\u9ad8\u4eb2\u548c\u529b\u53d7\u4f53\u7684\u7ec6\u80de\u5728\u4f53\u5185\u7684\u6269\u5c55\u3001\u6297\u80bf\u7624\u6548\u80fd\u548c\u8868\u9762\u6807\u8bb0\u8868\u578b\u65b9\u9762\u76f8\u4f3c\u3002\u6211\u4eec\u8fd8\u60ca\u8bb6\u5730\u53d1\u73b0\uff0c\u6cbb\u7597\u6027\u8f6c\u79fb\u7684T\u7ec6\u80de\u5728\u8f6c\u79fb\u540e\u51e0\u5929\u5185\u5728\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u4fdd\u6301\u4e86\u5176\u5e72\u7ec6\u80de\u6837\u8868\u578b\u3002<\/p>\n

SS: <\/strong>\u6211\u5df2\u7ecf\u7814\u7a76\u4e86\u591a\u5e74CD4+<\/sup> T\u7ec6\u80de\u5bf9CD8+<\/sup> T\u7ec6\u80de\u7684\u5e2e\u52a9\u673a\u5236\uff0c\u6240\u4ee5\u6211\u5bf9\u5b83\u4e5f\u80fd\u8c03\u8282\u65b0\u6297\u539f\u7279\u5f02\u6027\u5e94\u7b54\u611f\u5230\u6ee1\u8db3\uff0c\u800c\u4e0d\u662f\u60ca\u8bb6\u3002\u7136\u800c\uff0c\u6211\u786e\u5b9e\u611f\u5230\u60ca\u8bb6\u7684\u662f\uff0c\u9ad8\u4eb2\u548c\u529b\u548c\u9002\u5ea6\u4eb2\u548c\u529b\u7684CD4+<\/sup> T\u7ec6\u80de\u5728\u6548\u80fd\u4e0a\u4f3c\u4e4e\u6ca1\u6709\u592a\u5927\u533a\u522b\uff0c\u800c\u4e14\u4ed6\u4eec\u7684\u6cbb\u7597\u80fd\u529b\u6d89\u53ca\u5230\u4f9d\u8d56CD8\u548c\u72ec\u7acb\u4e8eCD8\u7684\u6d3b\u52a8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u524d\u666f\u5982\u4f55?<\/strong><\/p>\n

\n
\n
\n

SB:<\/strong> \u6211\u4eec\u5e0c\u671b\u8fd9\u4e9b\u53d1\u73b0\u5c06\u901a\u8fc7\u589e\u52a0\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u5174\u8da3\u6765\u5f71\u54cd\u8fd9\u4e2a\u9886\u57df\uff0c\u8fd9\u4e9b\u514d\u75ab\u6cbb\u7597\u9664\u4e86\u96c6\u4e2d\u5728\u7ec6\u80de\u6bd2\u6027\u7684CD8+<\/sup> T\u7ec6\u80de\u5916\uff0c\u8fd8\u5173\u6ce8CD4+<\/sup> T\u7ec6\u80de\uff0c\u800c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u514d\u75ab\u6cbb\u7597\u7684\u4e3b\u8981\u7126\u70b9\u4e00\u76f4\u662fCD8+<\/sup> T\u7ec6\u80de\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u5e94\u8be5\u786e\u5b9a\u901a\u8fc7\u91c7\u7528\u7c7b\u4f3c\u5e72\u7ec6\u80de\u7684\u65b0\u6297\u539f\u7279\u5f02\u6027CD4+<\/sup> T\u7ec6\u80de\u8fdb\u884c\u8f6c\u79fb\uff0c\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4ea7\u751f\u7684\u5e7f\u6cdb\u7ec6\u80de\u548c\u8f6c\u5f55\u7ec4\u6539\u53d8\u3002<\/p>\n

SS: <\/strong>\u554a\uff0c\u8fd9\u5c31\u662f\u6709\u8da3\u7684\u5730\u65b9\uff01\u76ee\u524d\u7684\u7ec6\u80de\u79fb\u690d\u7597\u6cd5\u6d89\u53ca\u5230\u9488\u5bf9\u80bf\u7624\u8868\u8fbe\u7684\u5355\u4e00\u9776\u6807\u6297\u539f\u7684\u5de5\u7a0b\u5316T\u7ec6\u80de\uff0c\u4eba\u4eec\u5728\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\uff0c\u5982\u679c\u80bf\u7624\u4e27\u5931\u6216\u4fee\u6539\u5176\u5bf9\u90a3\u4e2a\u6297\u539f\u7684\u8868\u8fbe\uff0c\u8fd9\u79cd\u65b9\u6cd5\u53ef\u80fd\u4f1a\u53d8\u5f97\u65e0\u6548\u3002\u6211\u4eec\u7684\u5de5\u4f5c\u663e\u793a\uff0c\u901a\u8fc7\u9488\u5bf9\u4ea4\u53c9\u5448\u9012\u80bf\u7624\u6297\u539f\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de\uff0c\u53ef\u4ee5\u5b9e\u73b0\u6709\u6548\u7684\u514d\u75ab\u6cbb\u7597\uff0c\u8fd9\u589e\u5f3a\u4e86\u6fc0\u6d3b\u800c\u975e\u6740\u4f24\u3002\u7136\u540e\u8fd9\u4e9b\u88ab\u6fc0\u6d3b\u7684APC\u53ef\u4ee5\u53d1\u52a8\u4e00\u652f\u9488\u5bf9\u8bb8\u591a\u80bf\u7624\u6297\u539f\u7684\u7ec6\u80de\u6bd2\u6027CD8+<\/sup> T\u7ec6\u80de\u519b\u961f\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u4e00\u4e2a\u3002\u6211\u4eec\u73b0\u5728\u5df2\u7ecf\u51c6\u5907\u597d\u5c06\u8fd9\u79cd\u65b9\u6cd5\u5e94\u7528\u5230\u4e34\u5e8a\u5b9e\u8df5\u4e2d\uff0c\u5982\u679c\u6210\u529f\uff0c\u8fd9\u79cd\u65b9\u6cd5\u53ef\u80fd\u4f1a\u4e3a\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u4f60\u6700\u8fd1\u5728\u5de5\u4f5c\u4e4b\u5916\u5b66\u5230\u7684\u6700\u9177\u7684\u4e8b\u60c5\u662f\u4ec0\u4e48?<\/strong><\/p>\n

\n
\n
\n

SS:\u6211\u6700\u8fd1\u6210\u4e86\u4e00\u4e2a\u201c\u7a7a\u5de2\u8001\u4eba\u201d\uff0c\u4e00\u76f4\u5728\u4eab\u53d7\u53d8\u5316\u5e26\u6765\u7684\u6240\u6709\u673a\u4f1a\uff1a\u66f4\u591a\u7684\u65c5\u884c\uff0c\u66f4\u5c11\u7684\u8d2d\u7269\uff0c\u66f4\u5b89\u9759\u7684\u751f\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n<\/section>\n
\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & Nat Immunol.<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u848b\u94b0\u6f47 \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
<\/span><\/span><\/section>\n
\u516c\u4f17\u53f7\u53d1\u900120230719\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n

<\/span><\/strong><\/p>\n


<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

CD4+ T \u7ec6\u80de\u5728\u6297\u764c\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u89d2\u8272\u5df2\u5f97\u5230\u5e7f\u6cdb\u786e\u8ba4\uff0c\u7136\u800c\u5176\u5177\u4f53\u7684\u4f5c\u7528\u673a\u5236\u4ee5\u53ca\u5f71\u54cd\u5176\u529f\u80fd\u7684\u56e0\u7d20\u4ecd\u5f85\u660e\u786e\u3002\u5728\u4e4b\u524d\u5bf9\u5c0f\u9f20\u7684\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u786e\u8ba4\u4e86\u7279\u5f02\u6027 CD4+ T \u7ec6\u80de\u5bf9\u4e8e M…<\/p>\n","protected":false},"author":1,"featured_media":5164,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[72],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5166"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5166"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5166\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5164"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5166"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5166"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}