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\u901a\u8fc7\u4f53\u5916\u4f7f\u7528\u4f4e\u7532\u57fa\u5316\u5242RG108\u5904\u7406TILs\uff0c\u53ef\u4ee5\u589e\u52a0\u5b83\u4eec\u5bf9Tcf7\u548cIl7r\u7684\u8868\u8fbe\u3002\u4e3a\u4e86\u63a2\u7a76\u8fd9\u662f\u5426\u80fd\u589e\u5f3a\u7ec6\u80de\u8f6c\u79fb\u6cbb\u7597\uff08ACT\uff09\uff0c\u7814\u7a76\u4eba\u5458\u5728\u4f53\u5916\u4f7f\u7528RG108\u5904\u7406IL-7Rhi<\/sup>\u6216IL-7Rlo<\/sup> CD8+<\/sup> T\u7ec6\u80de\u7fa4\u4f53\uff0c\u7136\u540e\u5c06\u5b83\u4eec\u8f6c\u79fb\u81f3\u672a\u7ecf\u514d\u75ab\u7684\u5c0f\u9f20\u4f53\u5185\u3002\u968f\u540e\uff0c\u5c0f\u9f20\u88abYUMMER1.7\uff08\u4e00\u79cd\u9ad8\u6297\u539f\u8d1f\u8f7d\u7684YUMM1.7\u80bf\u7624\u7ec6\u80de\u53d8\u4f53\uff0c\u4f46\u6ca1\u6709\u4e3b\u8981\u6297\u539f[CMV\u6216OVA]\uff09\u6311\u6218\u3002\u4e0e\u672a\u5904\u7406\u7684IL-7Rhi<\/sup>\u7ec6\u80de\u76f8\u6bd4\uff0c\u63a5\u79cdRG108\u5904\u7406\u540e\u7684IL-7Rhi<\/sup>\u7ec6\u80de\u80fd\u591f\u63d0\u4f9b\u66f4\u5f3a\u7684\u4fdd\u62a4\u514d\u75ab\u529b\uff0c\u5ef6\u957f\u5c0f\u9f20\u7684\u4e2d\u4f4d\u751f\u5b58\u65f6\u95f4\uff0c\u5e76\u4f7f75%\u7684\u5c0f\u9f20\u5b9e\u73b0\u80bf\u7624\u6e05\u9664\u3002\u6b64\u5916\uff0c\u7ecf\u8fc7RG108\u5904\u7406\u7684IL-7Rlo<\/sup>\u7ec6\u80de\u4e5f\u80fd\u591f\u63d0\u4f9b\u589e\u5f3a\u7684\u6297\u80bf\u7624\u514d\u75ab\u529b\uff0c\u6d88\u9664\u4e86\u4e4b\u524d\u89c2\u5bdf\u5230\u7684IL-7Rhi<\/sup>\u548cIL-7Rlo<\/sup>\u7ec6\u80de\u7fa4\u4f53\u4e4b\u95f4\u7684\u5dee\u5f02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u4e3a\u4e86\u7814\u7a76\u8fd9\u4e9b\u53d1\u73b0\u7684\u8f6c\u5316\u610f\u4e49\uff0cMicevic\u548cDaniels\u7b49\u4eba\u5728\u5927\u89c4\u6a21\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u961f\u5217\u4e2d\u5206\u6790\u4e86TME\u4e2d\u7684IL-7R\u8868\u8fbe\u3002\u4e0e\u5c0f\u9f20\u76f8\u4f3c\uff0c\u4eba\u7c7bIL-7Rhi<\/sup> CD8+<\/sup> T\u7ec6\u80de\u8868\u73b0\u51faTcf7\u542f\u52a8\u5b50\u7684\u4f4e\u7532\u57fa\u5316\uff0c\u4e0eIL-7Rlo<\/sup>\u7ec4\u76f8\u6bd4\uff0c\u5bf9\u5e94\u7740\u66f4\u9ad8\u7684TCF7\u8868\u8fbe\u3002\u4eba\u7c7bIL-7Rhi<\/sup> CD8+<\/sup> T\u7ec6\u80de\u4e5f\u8868\u8fbe\u4e86\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\u7684\u7c7b\u4f3c\u8bb0\u5fc6\u6027\u7684\u7532\u57fa\u5316\u6807\u8bb0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u786e\u5b9aIL-7R\u8868\u8fbe\u662f\u5426\u4e0e\u6301\u4e45\u7684\u6cbb\u7597\u53cd\u5e94\u548c\u751f\u5b58\u76f8\u5173\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u4e00\u5927\u6279\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5206\u4e3aIL-7Rhi<\/sup>\u548cIL-7Rlo<\/sup>\u7ec4\u3002\u4e0eIL-7Rlo<\/sup>\u7ec4\u76f8\u6bd4\uff0cIL-7Rhi<\/sup>\u961f\u5217\u5bcc\u96c6\u4e86\u4e0eT\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u548c\u514d\u75ab\u5e94\u7b54\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\uff0c\u5e76\u663e\u793a\u51fa\u5ef6\u957f\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08755\u5929 vs. 523\u5929\uff09\u548c\u603b\u751f\u5b58\u671f\uff082,421\u5929 vs. 875\u5929\uff09\u3002\u8fd9\u79cd\u76f8\u5173\u6027\u4e0d\u80fd\u5f52\u56e0\u4e8e\u5176\u4ed6\u9884\u540e\u56e0\u7d20\uff0c\u5e76\u4e14\u786e\u5b9aIL-7R\u8868\u8fbe\u662f\u603b\u4f53\u751f\u5b58\u671f\u7684\u72ec\u7acb\u9884\u540e\u56e0\u7d20\u3002\u6709\u8da3\u7684\u662f\uff0cTCF7\u4e0e\u751f\u5b58\u671f\u65e0\u76f8\u5173\u6027\uff0c\u8fd9\u8868\u660eIL-7R\u8868\u8fbe\u4e0d\u4ec5\u4ec5\u662f\u589e\u52a0\u5e72\u7ec6\u80de\u7279\u6027\u7684\u4f53\u73b0\u3002\u5728\u5927\u89c4\u6a21\u7684\u80ba\u764c\u60a3\u8005\u961f\u5217\u548c60\u4f8b\u63a5\u53d7\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u961f\u5217\u4e2d\u4e5f\u89c2\u5bdf\u5230\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u4e3a\u4e86\u4e86\u89e3IL-7R\u5982\u4f55\u5f71\u54cd\u5bf9\u6297CTLA-4\u548cPD-1\u7684\u6cbb\u7597\u53cd\u5e94\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u643a\u5e26\u80bf\u7624\u7684\u5c0f\u9f20\u8fdb\u884c\u4e86\u53cc\u91cd\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u3002\u5c3d\u7ba1\u540c\u65f6\u963b\u65adIL-7R\u548c\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u4e0d\u4f1a\u5f71\u54cd\u6297PD-1\u548c\u6297CTLA-4\u8bf1\u5bfc\u7684\u7f13\u89e3\uff0c\u4f46\u5b83\u786e\u5b9e\u5bfc\u81f4\u80bf\u7624\u590d\u53d1\u589e\u52a0\uff0c\u8fd9\u8868\u660eIL-7R\u4fe1\u53f7\u5728\u7ef4\u6301\u6301\u4e45\u6027\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u603b\u7684\u6765\u8bf4\uff0cMicevic\u548cDaniels\u7b49\u4eba\u7684\u7814\u7a76\u7ed3\u679c\u8868\u660e\u9ad8IL-7R\u8868\u8fbe\u662f\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u7684\uff0c\u5e76\u5728\u9650\u5236\u80bf\u7624\u590d\u53d1\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002IL-7Rhi<\/sup> CD8+<\/sup> T\u7ec6\u80de\u7fa4\u4f53\u5728\u6dcb\u5df4\u7ed3\u4e2d\u957f\u671f\u5b58\u5728\uff0c\u5728\u90a3\u91cc\u5b83\u4eec\u4fdd\u6301\u51c6\u5907\u72b6\u6001\uff0c\u968f\u65f6\u51c6\u5907\u5e94\u5bf9\u4efb\u4f55\u91cd\u65b0\u51fa\u73b0\u7684\u80bf\u7624\u7ec6\u80de\u3002\u6b64\u5916\uff0cIL-7Rhi<\/sup> CD8+<\/sup> T\u7ec6\u80de\u5728\u4e34\u5e8a\u4e0a\u5177\u6709\u5e7f\u6cdb\u5e94\u7528\u524d\u666f\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e3b\u8981\u9488\u5bf9\u80bf\u7624\uff0c\u53ef\u4ee5\u901a\u8fc7\u4f4e\u7532\u57fa\u5316\u5242\u589e\u5f3a\uff0c\u5e76\u4e14\u53ef\u4ee5\u5728\u4e0d\u9700\u8981\u9274\u5b9a\u7279\u5b9a\u80bf\u7624\u6297\u539f\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0\u6709\u6548\u7684\u7ec6\u80de\u8f6c\u79fb\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n

\u4f5c\u8005\u9762\u5bf9\u9762<\/strong><\/p>\n<\/section>\n

\n
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\n

\u672c\u5468\uff0c\u5171\u540c\u7b2c\u4e00\u4f5c\u8005Andrew Daniels\u548cGoran Micevic\u56de\u7b54\u4e86\u6211\u4eec\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
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\u5171\u540c\u7b2c\u4e00\u4f5c\u8005Goran Micevic\uff08\u5de6\uff09\u548cAndrew Daniels\uff08\u53f3\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5bf9\u4f60\u4eec\u6765\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u6700\u4ee4\u4eba\u60ca\u8bb6\u7684\u53d1\u73b0\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n

\n
\n
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AD\uff1a<\/strong>\u5bf9\u6211\u4eec\u6765\u8bf4\uff0c\u6700\u4ee4\u4eba\u60ca\u8bb6\u7684\u53d1\u73b0\u4e4b\u4e00\u662f\u4f7f\u7528\u4f4e\u7532\u57fa\u5316\u5242\u5bf9T\u7ec6\u80de\u8fdb\u884c\u9884\u5904\u7406\uff0c\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u5b83\u4eec\u7684\u6297\u80bf\u7624\u529f\u80fd\u3002\u4f4e\u7532\u57fa\u5316\u5242\u4e0d\u4ec5\u80fd\u591f\u589e\u5f3aT\u7ec6\u80de\u5728\u8f6c\u79fb\u81f3\u672a\u7ecf\u514d\u75ab\u7684\u5c0f\u9f20\u4e4b\u524d\u8868\u8fbe\u529f\u80fd\u6807\u5fd7\u7269\u7684\u6548\u529b\uff0c\u800c\u4e14\u5728\u5b8c\u5168\u4e0d\u8868\u8fbe\u8fd9\u4e9b\u6807\u5fd7\u7269\u7684\u5927\u91cfT\u7ec6\u80de\u4e2d\u4e5f\u80fd\u591f\u4ea7\u751f\u51e0\u4e4e\u76f8\u540c\u7684\u7597\u6548\u3002<\/p>\n

GM\uff1a<\/strong>\u963b\u65adIL-7R\u4ee5\u6d88\u9664\u5f3a\u6709\u529b\u7684\u529f\u80fd\u6027\u8bb0\u5fc6\u8868\u578b\u7684\u80fd\u529b\u4e5f\u662f\u4ee4\u4eba\u9707\u60ca\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u7814\u7a76\u610f\u4e49\u5982\u4f55\uff1f<\/strong><\/p>\n

\n
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AD\uff1a<\/strong>\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u4e34\u5e8a\u521b\u65b0\u63d0\u4f9b\u4e86\u4e00\u4e2a\u4ee4\u4eba\u5174\u594b\u7684\u9886\u57df\u3002\u8fd1\u5e74\u6765\uff0c\u6211\u4eec\u5bf9\u5728\u80bf\u7624\u73af\u5883\u4e2d\u53d1\u751f\u7684T\u7ec6\u80de\u5927\u91cf\u518d\u7f16\u7a0b\u7684\u4e00\u4e9b\u8868\u89c2\u9057\u4f20\u673a\u5236\u6709\u4e86\u66f4\u597d\u7684\u7406\u89e3\u3002\u6211\u4eec\u8ba4\u4e3a\uff0c\u7ec6\u80de\u8f6c\u79fb\u7597\u6cd5\u662f\u53ef\u4ee5\u4ece\u8fd9\u4e9b\u521b\u65b0\u4e2d\u83b7\u76ca\u7684\u5173\u952e\u6cbb\u7597\u65b9\u5f0f\u4e4b\u4e00\u3002<\/p>\n

GM\uff1a<\/strong>\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u5c06\u9700\u8981\u786e\u5b9a\u5173\u952e\u7684\u8868\u89c2\u9057\u4f20\u9a71\u52a8\u56e0\u7d20\u548c\u6700\u4f73\u7684\u9776\u5411\u65b9\u6cd5\u3002\u5173\u4e8e\u6210\u529f\u7684\u6297\u80bf\u7624\u8bb0\u5fc6\u53cd\u5e94\u7684\u89e3\u6790\u4ecd\u7136\u5b58\u5728\u91cd\u8981\u95ee\u9898\uff0c\u5305\u62ec\u65f6\u95f4\u8868\u3001\u4fe1\u53f7\u3001\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u4ee5\u53ca\u53d1\u751f\u8fd9\u4e9b\u53cd\u5e94\u7684\u533a\u57df\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u5de5\u4f5c\u4e4b\u5916\uff0c\u4f60\u6700\u8fd1\u4e86\u89e3\u5230\u7684\u6700\u9177\u7684\u4e8b\u60c5\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n

\n
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AD\uff1a<\/strong>\u5bf9\u6211\u6765\u8bf4\uff0c\u6700\u8fd1\u4e00\u76f4\u5728\u5173\u6ce8\u91c7\u96c6\u8611\u83c7\uff01\u4f60\u53ef\u4ee5\u91c7\u96c6\u5230\u8bb8\u591a\u65e0\u6cd5\u683d\u57f9\u7684\u7f8e\u5473\u54c1\u79cd\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0e\u6811\u6728\u4e4b\u95f4\u5f62\u6210\u4e86\u590d\u6742\u7684\u5173\u7cfb\u4ee5\u83b7\u53d6\u517b\u5206\u3002\u8fd9\u4f7f\u5f97\u91c7\u96c6\u6210\u4e3a\u4e00\u4e2a\u975e\u5e38\u9177\u7684\u673a\u4f1a\uff01<\/p>\n

GM\uff1a<\/strong>\u6211\u6700\u8fd1\u4e86\u89e3\u5230\uff0c\u6d77\u6d0b\u7845\u85fb\uff0c\u4e5f\u5c31\u662f\u5355\u7ec6\u80de\u85fb\u7c7b\uff0c\u4ea7\u751f\u4e86\u6211\u4eec\u4f7f\u7528\u7684\u5927\u90e8\u5206\u6c27\u6c14\uff01\u5c31\u50cfT\u7ec6\u80de\u4e00\u6837\uff0c\u5b83\u4eec\u867d\u5c0f\u5374\u5f3a\u5927\u3002\u8fd9\u4e2a\u63cf\u8ff0\u4e5f\u9002\u7528\u4e8e\u6211\u7684\u4e09\u5c81\u5b69\u5b50\uff0c\u5e76\u63d0\u9192\u6211\u73cd\u60dc\u751f\u6d3b\u4e2d\u90a3\u4e9b\u4ee4\u4eba\u60ca\u5947\u7684\u201c\u5c0f\u4e8b\u7269\u201d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & PNAS<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u4efb\u632f\u9633 \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
<\/span><\/span><\/section>\n
\u516c\u4f17\u53f7\u53d1\u900120230802\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n

<\/span><\/strong><\/p>\n


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\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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