{"id":5173,"date":"2023-08-30T07:00:11","date_gmt":"2023-08-29T23:00:11","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/30\/immunity-20230705-treg%e7%bb%86%e8%83%9e%e4%b8%8a%e7%9a%84cxcr3%e6%8e%a7%e5%88%b6%e7%9d%80%e5%ae%83%e4%bb%ac%e7%9a%84%e7%b4%af%e7%a7%af%e5%92%8c%e6%bf%80%e6%b4%bb\/"},"modified":"2023-08-30T07:00:11","modified_gmt":"2023-08-29T23:00:11","slug":"immunity-20230705-treg%e7%bb%86%e8%83%9e%e4%b8%8a%e7%9a%84cxcr3%e6%8e%a7%e5%88%b6%e7%9d%80%e5%ae%83%e4%bb%ac%e7%9a%84%e7%b4%af%e7%a7%af%e5%92%8c%e6%bf%80%e6%b4%bb","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/30\/immunity-20230705-treg%e7%bb%86%e8%83%9e%e4%b8%8a%e7%9a%84cxcr3%e6%8e%a7%e5%88%b6%e7%9d%80%e5%ae%83%e4%bb%ac%e7%9a%84%e7%b4%af%e7%a7%af%e5%92%8c%e6%bf%80%e6%b4%bb\/","title":{"rendered":"Immunity. 20230705: Treg\u7ec6\u80de\u4e0a\u7684CXCR3\u63a7\u5236\u7740\u5b83\u4eec\u7684\u7d2f\u79ef\u548c\u6fc0\u6d3b"},"content":{"rendered":"
\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n

\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u7ecf\u5e38\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u6784\u6210\u6311\u6218\uff0c\u4f46\u5b83\u4eec\u5982\u4f55\u6291\u5236\u514d\u75ab\u53cd\u5e94\u5c1a\u672a\u5b8c\u5168\u7406\u89e3\u3002\u5728\u5bf9Tregs\u5728\u80bf\u7624\u4e2d\u7684\u79ef\u7d2f\u548c\u6fc0\u6d3b\u8fdb\u884c\u7814\u7a76\u65f6\uff0cMoreno Ayala\u7b49\u4eba\u53d1\u73b0CXCR3+<\/sup> Tregs\u5728\u80bf\u7624\u4e2d\u66f4\u503e\u5411\u4e8e\u4e0eCXCL9+<\/sup> DC1\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e14\u5728Tregs\u4e2d\u7279\u5f02\u6027\u57fa\u56e0\u6572\u9664CXCR3\u589e\u5f3a\u4e86DC1\u7ec6\u80de\u5bf9\u80bf\u7624\u6297\u539f\u7684\u4ea4\u53c9\u5448\u9012\u3001\u5bf9CD8+<\/sup> T\u7ec6\u80de\u7684\u6fc0\u6d3b\u4ee5\u53ca\u6297\u80bf\u7624\u514d\u75ab\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u6700\u8fd1\u53d1\u8868\u5728\u300aImmunity\u300b\u6742\u5fd7\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

Moreno Ayala\u7b49\u4eba\u9996\u5148\u7814\u7a76\u4e86\u643a\u5e26MC38\u7ed3\u80a0\u764c\u3001EL4\u80f8\u817a\u6dcb\u5df4\u7624\u62169464D\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u7684\u5c0f\u9f20\u4e2d\u7684T\u7ec6\u80de\u8868\u578b\u3002\u5c3d\u7ba1Tregs\u548cCD8+<\/sup> T\u7ec6\u80de\u7684\u9891\u7387\u5728\u4e0d\u540c\u80bf\u7624\u4e2d\u5b58\u5728\u5dee\u5f02\uff0c\u4f46\u4e24\u79cd\u7ec6\u80de\u7fa4\u4f53\u4e4b\u95f4\u59cb\u7ec8\u5b58\u5728\u6b63\u76f8\u5173\u6027\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u6ce8\u610f\u5230\uff0c\u4e0e\u5065\u5eb7\u7ec4\u7ec7\u548c\u5916\u5468\u6dcb\u5df4\u7ed3\u76f8\u6bd4\uff0cCXCR3\u5728\u80bf\u7624\u548c\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u7684CD8+<\/sup> T\u7ec6\u80de\u3001\u6548\u5e94\u6027CD4+<\/sup> T\u7ec6\u80de\u548cTregs\u4e0a\u7684\u8868\u8fbe\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u52a8\u529b\u5b66\u8bc4\u4f30\u663e\u793a\uff0cTregs\u4e2dCXCR3\u8868\u8fbe\u7684\u5cf0\u503c\uff0c\u4e0eCXCR3+<\/sup>CD8+<\/sup> T\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u6d78\u6da6\u6709\u76f8\u5173\u6027\uff0c\u6b64\u65f6Tregs\u5f00\u59cb\u5728\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u79ef\u805a\u3002\u5728\u80bf\u7624\u6d78\u6da6\u7684\u9ad8\u5cf0\u671f\uff0c\u7ecf\u5386\u6297\u539f\u523a\u6fc0\u7684\uff08CD44+<\/sup>\uff09CXCR3+<\/sup> Tregs\u76f8\u5bf9\u4e8eCD44+<\/sup>CXCR3–<\/sup> Tregs\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u6fc0\u6d3b\u6807\u8bb0\u7269\u548c\u6548\u5e94\u529f\u80fd\uff08CD69\u3001CD103\u3001KLRG1\u3001PD-1\u548cCTLA-4\uff09\u3002\u7efc\u5408\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cCXCR3\u7684\u8868\u8fbe\u652f\u6301Tregs\u5728\u80bf\u7624\u4e2d\u7684\u589e\u52a0\u79ef\u7d2f\u548c\u6fc0\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u4e3a\u4e86\u4e13\u95e8\u7814\u7a76CXCR3\u5bf9Tregs\u7684\u5f71\u54cd\uff0cMoreno Ayala\u7b49\u4eba\u5229\u7528\u96cc\u6027\u5c0f\u9f20\u7684X\u67d3\u8272\u4f53\u5931\u6d3b\u751f\u6210\u4e86\u9057\u4f20\u5b66\u5c0f\u9f20\u6a21\u578b\u3002\u5728\u8fd9\u4e9b\u6a21\u578b\u4e2d\uff0c\u5c0f\u9f20\u542b\u6709CXCR3+<\/sup>\u548cCXCR3KO<\/sup> Tregs\u7684\u5f02\u8d28\u7fa4\u4f53\uff0c\u5e76\u53ef\u4ee5\u901a\u8fc7\u7ed9\u4e88\u767d\u5589\u6bd2\u7d20\u6765\u6e05\u9664\u5176\u4e2d\u4e00\u79cdTreg\u7fa4\u4f53\uff08\u6839\u636e\u6a21\u578b\u7684\u4e0d\u540c\uff09\u3002\u5728\u6e05\u9664CXCR3+<\/sup> Tregs\u7684\u5c0f\u9f20\u4e2d\uff08\u53ea\u5269\u4e0bCXCR3KO<\/sup> Tregs\uff09\uff0c\u4e0e\u4fdd\u7559CXCR3+<\/sup> Tregs\u5b8c\u6574\u6216\u6e05\u9664CXCR3KO<\/sup>\u7ec6\u80de\u7684\u60c5\u51b5\u76f8\u6bd4\uff0cMC38\u3001EL4\u548c9464D\u80bf\u7624\u7684\u751f\u957f\u5ef6\u8fdf\u3002\u5f53\u6e05\u9664\u4e00\u5b9a\u6bd4\u4f8b\u7684Tregs\u800c\u4e0d\u8003\u8651CXCR3\u65f6\uff0c\u8fd9\u79cd\u6548\u5e94\u5e76\u672a\u89c2\u5bdf\u5230\uff0c\u8fd9\u8868\u660eCXCR3+<\/sup> Tregs\u5728\u7279\u5b9a\u6291\u5236\u6297\u80bf\u7624\u6548\u5e94\u4e2d\u53d1\u6325\u7740\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u5728CXCR3KO<\/sup> Tregs\u60c5\u51b5\u4e0b\uff0c\u5305\u62ec\u4e00\u7fa4\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027CD8+<\/sup> T\u7ec6\u80de\u5728\u5185\u7684CD8+<\/sup> T\u7ec6\u80de\u5728MC38\u3001EL4\u548c9464D\u6a21\u578b\u7684\u80bf\u7624\u4e2d\u589e\u52a0\u3002\u901a\u8fc7\u4f53\u5916\u518d\u523a\u6fc0\u540e\u68c0\u6d4bIFN\u03b3\u548cTNF\u0251\u7684\u4ea7\u751f\u91cf\u53d1\u73b0\uff0cTregs\u4e2d\u7684CXCR3\u7f3a\u9677\u5e76\u4e0d\u5f71\u54cdCD8+<\/sup> T\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u540c\u6837\u4e5f\u6ca1\u6709\u5f71\u54cdPD-1\u7684\u8868\u8fbe\uff0c\u8fd9\u8868\u660eCXCR3+<\/sup> Tregs\u9650\u5236\u4e86CD8+<\/sup> T\u7ec6\u80de\u7684\u79ef\u7d2f\uff0c\u4f46\u4e0d\u5f71\u54cd\u5176\u6fc0\u6d3b\u3002\u6b64\u5916\uff0c\u6dfb\u52a0\u6297PD-1\u6297\u4f53\u53ef\u7528\u4e8e\u589e\u5f3a\u6297\u80bf\u7624\u6548\u679c\u3002\u901a\u8fc7\u89c2\u5bdf\u80bf\u7624\u4e2dTreg\u7684\u79ef\u7d2f\uff0c\u7814\u7a76\u4eba\u5458\u6ce8\u610f\u5230Treg\u7684\u9891\u7387\u7a0d\u5fae\u964d\u4f4e\u5e76\u4e14\u4e0eCXCR3\u7f3a\u4e4f\u5448\u76f8\u5173\u6027\u3002\u5728\u4e00\u4e2a\u57fa\u56e0\u5de5\u7a0b\u7684\u8089\u7624\u53d1\u751f\u5c0f\u9f20\u6a21\u578b\uff08\u975e\u79fb\u690d\uff09\u4e2d\u4e5f\u89c2\u5bdf\u5230\u7c7b\u4f3c\u7684\u6548\u679c\uff0c\u5373\u5728\u8089\u7624\u5f62\u6210\u540e\u6e05\u9664CXCR3+<\/sup> T\u7ec6\u80de\u5bfc\u81f4\u80bf\u7624\u5185CD8+<\/sup> T\u7ec6\u80de\u589e\u52a0\u548cTregs\u51cf\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u89c2\u5bdfCXCR3KO<\/sup> Tregs\u7684\u7279\u6027\uff0c\u7814\u7a76\u4eba\u5458\u6ce8\u610f\u5230\u5728MC38\u80bf\u7624\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0cPD-1\u548cCTLA-4\u7684\u8868\u8fbe\u964d\u4f4e\uff0c\u8868\u660e\u5176\u6d3b\u5316\u8868\u578b\u8f83\u5f31\u3002\u5728\u540c\u65f6\u5b58\u5728CXCR3+<\/sup>\u548cCXCR3KO<\/sup> Tregs\u7684\u5c0f\u9f20\u4e2d\u8fdb\u884c\u76f4\u63a5\u7ade\u4e89\u6027\u6d4b\u8bd5\u65f6\uff0c\u4e0eCXCR3+<\/sup>\u7ec6\u80de\u76f8\u6bd4\uff0cCXCR3KO<\/sup> Tregs\u5728\u80bf\u7624\u548c\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u6240\u5360\u7684Tregs\u6bd4\u4f8b\u8f83\u5c0f\uff0c\u5e76\u4e14\u8868\u8fbe\u7684PD-1\u548cCTLA-4\u8f83\u5c11\uff0c\u518d\u6b21\u8868\u660eCXCR3\u6709\u52a9\u4e8e\u80bf\u7624\u7ec4\u7ec7\u4e2dTreg\u7684\u4f18\u5148\u79ef\u7d2f\u548c\u6fc0\u6d3b\u3002\u66f4\u8fdb\u4e00\u6b65\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u8fc7\u7ee7\u6027\u5730\u8f6c\u79fb\u4f53\u5916\u6fc0\u6d3b\u548c\u5206\u5316\u7684\u8868\u8fbe\u6216\u4e0d\u8868\u8fbeCXCR3\u7684Th1\u6837Tbet+<\/sup> Treg\uff0c\u968f\u540e\u68c0\u6d4b\u4e86CXCR3+<\/sup> Treg\u7684\u79ef\u7d2f\u3002\u5728\u8f6c\u79fb\u5230MC38\u80bf\u7624\u5c0f\u9f20\u540e\uff0c\u4e0eWT Tregs\u76f8\u6bd4\uff0cCXCR3KO<\/sup> Tregs\u5728\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u5bcc\u96c6\uff0c\u4f46\u5728\u80bf\u7624\u4e2d\u51cf\u5c11\uff0c\u8fd9\u8868\u660eCXCR3\u8868\u8fbe\u672c\u8eab\u5bf9\u4e8eTreg\u5728\u80bf\u7624\u4e2d\u7684\u7d2f\u79ef\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u5047\u8bbeTregs\u4e2d\u7684CXCR3\u53ef\u80fd\u901a\u8fc7\u4fc3\u8fdbTreg\u4e0eDC\u7684\u5171\u5b9a\u4f4d\u548c\u8c03\u8282\u6765\u53d1\u6325\u4f5c\u7528\uff0c\u5df2\u77e5\u5728C57BL\/6\u5c0f\u9f20\u4e2d\uff0cDC\u4ea7\u751fCXCR3\u914d\u4f53CXCL9\u548cCXCL10\u3002\u4e3a\u4e86\u7814\u7a76\u8fd9\u4e00\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u5e26\u6709\u8367\u5149\u6807\u8bb0\u7684\u5c0f\u9f20\u6a21\u578b\uff0c\u4f7f\u4ed6\u4eec\u80fd\u591f\u53ef\u89c6\u5316\u548c\u91cf\u5316Tregs\u4e0eCD11c+<\/sup> DC\u4ee5\u53caCD8+<\/sup> T\u7ec6\u80de\u4e0eDC\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u7ed3\u679c\u663e\u793a\uff0cCXCR3\u7f3a\u9677\u7684Treg\u4e0eDC\u76f8\u4e92\u4f5c\u7528\u7684\u53ef\u80fd\u6027\u4f4e\u4e8eCXCR3\u6b63\u5e38\u7684Treg\uff0c\u800c\u5f53Treg\u7f3a\u4e4fCXCR3\u65f6\uff0cCD8+<\/sup> T\u7ec6\u80de\u589e\u52a0\u5e76\u66f4\u53ef\u80fd\u4e0eDC\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u540c\u65f6\u5b58\u5728CXCR3+<\/sup>\u548cCXCR3KO<\/sup>\u7ec6\u80de\u7684\u7ade\u4e89\u6027\u73af\u5883\u4e2d\uff0cTreg\u4e0eDC\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c\u7c7b\u4f3c\uff0c\u4f46\u5bf9CD8\u4e0eDC\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u7684\u5f71\u54cd\u88ab\u9006\u8f6c\u4e86\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u4e86CXCL9\u548cCXCL10\u7684\u4ea7\u751f\u60c5\u51b5\uff0c\u53d1\u73b0CXCL9\u51e0\u4e4e\u5b8c\u5168\u7531DC\u4ea7\u751f\uff0c\u800cCXCL9+<\/sup>CD11c+<\/sup>\u7ec6\u80de\u7684\u6570\u91cf\u4e0e\u91ce\u751f\u578bTregs\u7684\u6570\u91cf\u5448\u6b63\u76f8\u5173\u3002\u5f53Tregs\u4e2d\u6572\u9664CXCR3\u65f6\uff0c\u8fd9\u79cd\u6b63\u76f8\u5173\u6027\u8f83\u5f31\uff0c\u5e76\u4e14\u5728CXCL10\u4e2d\u6ca1\u6709\u89c2\u5bdf\u5230\u8fd9\u79cd\u73b0\u8c61\uff0c\u56e0\u4e3aCXCL10\u7684\u4ea7\u751f\u4e0d\u4ec5\u9650\u4e8eDC\u3002\u5728\u7f3a\u4e4fCD8+<\/sup> T\u7ec6\u80de\u6216IFN\u03b3\u7684\u60c5\u51b5\u4e0b\uff0cCXCL9\u51cf\u5c11\uff0c\u8fd9\u652f\u6301\u4e86\u4e00\u79cd\u5047\u8bbe\uff0c\u5373CD8+<\/sup> T\u7ec6\u80de\u4ea7\u751f\u7684IFN\u03b3\u53ef\u80fd\u6709\u52a9\u4e8eDC\u4e0a\u8c03CXCL9\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u5438\u5f15CXCR3+<\/sup> Tregs\u3002\u901a\u8fc7\u8fc7\u7ee7\u8f6c\u79fb\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8fd9\u4e00\u5047\u8bbe\uff0c\u7ed3\u679c\u663e\u793a\u5728\u7f3a\u4e4fDC1\u7684\u5c0f\u9f20\u4e2d\uff0cCXCR3+<\/sup> Tregs\u5728\u80bf\u7624\u4e2d\u7d2f\u79ef\u589e\u591a\u7684\u73b0\u8c61\u6d88\u5931\u4e86\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u6700\u540e\uff0c\u7814\u7a76\u4eba\u5458\u5047\u8bbeCXCR3+<\/sup> Treg\u7ec6\u80de\u53ef\u80fd\u8c03\u8282DC1\u6fc0\u6d3b\u6297\u80bf\u7624CD8+<\/sup> T\u7ec6\u80de\u53cd\u5e94\u7684\u80fd\u529b\uff0c\u4f7f\u7528\u8868\u8fbeOVA\u7684MHC-I\u7f3a\u9677\u7684MC38\u80bf\u7624\u6765\u6d4b\u8bd5\u4ed6\u4eec\u7684\u5047\u8bbe\uff0c\u8fd9\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u80fd\u591f\u6d4b\u91cfCD8+<\/sup> T\u7ec6\u80de\u5bf9DC\u4ea4\u53c9\u5448\u9012\u7684\u53cd\u5e94\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728CXCR3KO<\/sup> Tregs\u7684\u80cc\u666f\u4e0b\uff0c\u80bf\u7624\u548c\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u7684OVA\u7279\u5f02\u6027CD8+<\/sup> T\u7ec6\u80de\u663e\u8457\u589e\u52a0\uff0c\u800c\u5728CXCR3+<\/sup> Tregs\u7684\u80cc\u666f\u4e0b\u5219\u6ca1\u6709\u3002\u8fd9\u79cd\u6548\u5e94\u4f9d\u8d56\u4e8eDC1\u7684\u5b58\u5728\u3002\u4f7f\u7528\u7ed3\u5408SIINFEKL\/H-2Kb\u590d\u5408\u7269\u7684\u6297\u4f53\u8fdb\u4e00\u6b65\u786e\u8ba4\u4e86DC1\u5bf9\u80bf\u7624\u6297\u539f\u7684\u4ea4\u53c9\u5448\u9012\u589e\u5f3a\u3002<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7ed3\u679c\u63cf\u8ff0\u4e86\u4e00\u79cd\u673a\u5236\uff0c\u5373CD8+<\/sup> T\u7ec6\u80de\u4ea7\u751f\u7684IFN\u03b3\u589e\u5f3a\u4e86DC1\u4e2dCXCL9\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u62db\u52dfCXCR3+<\/sup> Tregs\u3002\u8fd9\u4e9bCXCR3+<\/sup> Tregs\u53cd\u8fc7\u6765\u589e\u52a0\u4e86CXCL9+<\/sup> DC1\u7684\u6570\u91cf\uff0c\u4f46\u9650\u5236\u4e86DC1\u5bf9\u80bf\u7624\u6297\u539f\u7684\u4ea4\u53c9\u5448\u9012\uff0c\u963b\u788d\u4e86\u6297\u80bf\u7624CD8+<\/sup> T\u7ec6\u80de\u7684\u6fc0\u6d3b\u8fc7\u7a0b\uff0c\u5e76\u9650\u5236\u4e86\u5b83\u4eec\u5bf9\u764c\u75c7\u8fdb\u5c55\u7684\u63a7\u5236\u80fd\u529b\u3002Tregs\u4e2d\u7684CXCR3\u6572\u9664\u589e\u5f3a\u4e86DC1\u7684\u4ea4\u53c9\u5448\u9012\u3001CD8+<\/sup> T\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u6297\u80bf\u7624\u6548\u679c\uff0c\u8fd9\u8868\u660eCXCR3\u53ef\u80fd\u6210\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u6f5c\u5728\u9776\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & Immunity<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u7f57\u8377 \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
<\/span><\/span><\/section>\n
\u516c\u4f17\u53f7\u53d1\u900120230705\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n

<\/span><\/strong><\/p>\n


<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u7ecf\u5e38\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u6784\u6210\u6311\u6218\uff0c\u4f46\u5b83\u4eec\u5982\u4f55\u6291\u5236\u514d\u75ab\u53cd\u5e94\u5c1a\u672a\u5b8c\u5168\u7406\u89e3\u3002\u5728\u5bf9Tregs\u5728\u80bf\u7624\u4e2d\u7684\u79ef\u7d2f\u548c\u6fc0\u6d3b\u8fdb\u884c\u7814\u7a76\u65f6\uff0cMoreno Ayala\u7b49\u4eba\u53d1\u73b0CXCR3+ …<\/p>\n","protected":false},"author":1,"featured_media":5171,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[72],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5173"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5173"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5173\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5171"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5173"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}