{"id":5192,"date":"2023-10-08T20:06:34","date_gmt":"2023-10-08T12:06:34","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/10\/08\/2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%80\/"},"modified":"2023-10-08T20:06:34","modified_gmt":"2023-10-08T12:06:34","slug":"2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%80","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/10\/08\/2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%80\/","title":{"rendered":"2023\u5e74\u56fd\u9645\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\u4e00"},"content":{"rendered":"
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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1.<\/strong>\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u4ee3\u8c22<\/strong><\/p>\n

Guoliang Cui – HI-TRON\/\u5fb7\u56fd\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3DKFZ\uff0c\u8fc8\u56e0\u8328\/\u6d77\u5fb7\u5821\uff0c\u5fb7\u56fd<\/span><\/strong><\/p>\n<\/section>\n

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2.<\/strong>\u6162\u6027\u611f\u67d3\u548c\u764c\u75c7\u671f\u95f4T\u7ec6\u80de\u7684\u751f\u5b58\u65b9\u5f0f\uff1a\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u610f\u4e49<\/strong><\/p>\n<\/section>\n

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Rafi Ahmed-\u7f8e\u56fd\u4e9a\u7279\u5170\u5927\u57c3\u9ed8\u91cc\u5927\u5b66\u533b\u5b66\u9662<\/strong><\/p>\n<\/section>\n

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\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u5411\u672b\u671f\u611f\u67d3\u6216\u764c\u75c7\u60a3\u8005\u7684\u6cbb\u7597\u4e2d\u6dfb\u52a0IL-2\u53ef\u80fd\u4f1a\u63d0\u9ad8\u6297PD-1\u8f74\u6cbb\u7597\u7684\u6548\u679c\u3002\u6b64\u5916\uff0c\u8fd9\u4e5f\u8bc1\u5b9e\u4e86\u5e72\u7ec6\u80de\u6837\u7684CD8+<\/sup> T\u7ec6\u80de\u5728\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u5b83\u4eec\u662f\u7ef4\u6301\u957f\u671f\u6297\u611f\u67d3\u6216\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684\u91cd\u8981\u56e0\u7d20\u3002\u8fd9\u79cd\u7406\u89e3\u4e0d\u4ec5\u6709\u52a9\u4e8e\u6211\u4eec\u66f4\u597d\u5730\u7406\u89e3\u514d\u75ab\u7cfb\u7edf\u5982\u4f55\u5e94\u5bf9\u6162\u6027\u75c5\u6bd2\u611f\u67d3\u548c\u764c\u75c7\uff0c\u800c\u4e14\u4e5f\u4e3a\u53d1\u5c55\u65b0\u7684\u514d\u75ab\u7597\u6cd5\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.<\/strong>\u9776\u5411\u6811\u7a81\u72b6\u7ec6\u80de\u6cbb\u7597\u764c\u75c7<\/strong><\/p>\n<\/section>\n

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Miriam Merad-\u7f8e\u56fd\u7ebd\u7ea6\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662<\/strong>
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\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff08Tumor Immune Microenvironment\uff0cTIME\uff09\u4e2d\u7684\u708e\u75c7\u7ec6\u80de\u5bf9\u75be\u75c5\u7684\u8fdb\u7a0b\u5177\u6709\u76f4\u63a5\u5f71\u54cd\u3002\u4e3a\u4e86\u63ed\u793a\u5e76\u5229\u7528\u8fd9\u80cc\u540e\u7684\u673a\u5236\uff0cMiriam Merad\u4e13\u6ce8\u4e8e\u7814\u7a76\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7684\u4f5c\u7528\u3002\u6811\u7a81\u72b6\u7ec6\u80de\u8d1f\u8d23\u5c06\u514d\u75ab\u8377\u8f7d\uff08immune cargo\uff09\u4f20\u9012\u5230\u6dcb\u5df4\u7ed3\u4ee5\u542f\u52a8T\u7ec6\u80de\u53cd\u5e94\uff0c\u800c\u5de8\u566c\u7ec6\u80de\u65e2\u80fd\u63a7\u5236\u708e\u75c7\u4ee5\u4fc3\u8fdb\u4fee\u590d\uff0c\u4e5f\u80fd\u5f15\u53d1\u514d\u75ab\u6291\u5236\u3002Merad\u5229\u7528\u4e86\u672f\u524d\u73af\u5883\uff0c\u8be6\u7ec6\u63cf\u8ff0\u4e86\u5979\u548c\u4e00\u4e2a\u591a\u5b66\u79d1\u56e2\u961f\u5171\u540c\u5efa\u7acb\u7684TARGET\u5e73\u53f0\uff08\u65b0\u8f85\u52a9\u7814\u7a76\u5c0f\u7ec4\u8bc4\u4f30\u6cbb\u7597\u65b9\u6cd5\uff09\u7684\u4f18\u52bf\uff0c\u8be5\u5e73\u53f0\u80fd\u5bf9\u57fa\u7ebf\u548c\u514d\u75ab\u6270\u52a8\u540e\u7684TIME\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u5df2\u7ecf\u53d1\u8868\u7684\u6765\u81eaTARGET\u5e73\u53f0\u7684\u7814\u7a76\u4e2d\uff0c\u809d\u7ec6\u80de\u764c\u60a3\u8005\u5bf9PD-1\u963b\u65ad\u6cbb\u7597\u7684\u53cd\u5e94\u4e0e\u5426\uff0c\u5bfc\u81f4\u4e86\u5176\u514d\u75ab\u7ec6\u80de\u6570\u91cf\u548c\u79cd\u7c7b\u7684\u5dee\u5f02\u3002\u5728\u5bf9PD-1\u963b\u65ad\u53cd\u5e94\u7684\u60a3\u8005\u4e2d\uff0c\u6269\u589e\u4e86\u4e00\u90e8\u5206PD-1hi<\/sup>IL-21+<\/sup>CXCL13+<\/sup>\u7c7b\u4f3c\u6dcb\u5df4\u6ee4\u6ce1\u8f85\u52a9\u6027\u7684CD4+<\/sup> T\u7ec6\u80de\u548c\u6548\u5e94\u6027CD8+<\/sup> T\u7ec6\u80de\uff0c\u800c\u5728\u672a\u53cd\u5e94\u8005\u4e2d\uff0c\u7ec8\u672b\u8017\u7aed\u7684CD8+<\/sup> T\u7ec6\u80de\u548c\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u7684\u6c34\u5e73\u8f83\u9ad8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u867d\u7136\u5728\u6cbb\u7597\u524d\u5c31\u5b58\u5728\u5e76\u5728\u6cbb\u7597\u540e\u6269\u589e\u7684T\u7ec6\u80de\u5728\u54cd\u5e94\u8005\u548c\u975e\u54cd\u5e94\u8005\u7684\u80bf\u7624\u75c5\u7076\u4e2d\u90fd\u6709\u9ad8\u5ea6\u6d78\u6da6\uff0c\u4f46\u5176\u8868\u578b\u8f68\u8ff9\u5404\u5f02\u3002\u4e3a\u4e86\u7814\u7a76\u5bfc\u81f4\u4e0d\u540c\u53cd\u5e94\u7684\u5c40\u90e8\u56e0\u7d20\uff0cMerad\u4f7f\u7528\u4e86PIC-Seq\u6280\u672f\uff0c\u8fd9\u662f\u4e00\u79cd\u80fd\u9274\u5b9a\u4ece\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5206\u79bb\u51fa\u7684\u7269\u7406\u76f8\u4e92\u4f5c\u7528\u7ec6\u80de\u8868\u578b\u7684\u6280\u672f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6709\u8da3\u7684\u662f\uff0c\u54cd\u5e94\u8005\u4e2d\u53d1\u73b0\u4e86\u514d\u75ab\u8c03\u8282\u6027mregDCs\u3001CXCL13+<\/sup>CD4+<\/sup> T\u7ec6\u80de\u548c\u524d\u4f53CD8+<\/sup> T\u7ec6\u80de\u4e4b\u95f4\u7684\u4e09\u91cd\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u4e0eCD8+<\/sup>\u6548\u5e94\u7ec6\u80de\u7684\u5bcc\u96c6\u6709\u5173\uff0c\u4f46\u5728\u975e\u54cd\u5e94\u8005\u4e2d\u4e5f\u5b58\u5728\u3002mregDCs\u548cCD4+<\/sup> T\u7ec6\u80de\u5171\u4eab\u591a\u4e2a\u53d7\u4f53-\u914d\u4f53\u5bf9\uff0c\u5728\u54cd\u5e94\u8005\u4e2d\u5bfc\u81f4\u4e86\u6548\u5e94\u6027CD8+<\/sup>\u7ec6\u80de\u7684\u4ea7\u751f\uff0c\u4f46\u5728\u975e\u54cd\u5e94\u8005\u4e2d\u5219\u5bfc\u81f4\u4e86\u7ec8\u672b\u7ec6\u80de\u7684\u5f62\u6210\uff0c\u8fd9\u5f15\u53d1\u4e86\u4e00\u4e2a\u95ee\u9898\uff1a\u5728\u4e0d\u540c\u7684\u751f\u6001\u4f4d\u4e2d\uff0cmregDCs\u662f\u5982\u4f55\u4e0d\u540c\u5730\u53d1\u6325\u529f\u80fd\u5e76\u5bfc\u81f4\u5982\u6b64\u4e0d\u540c\u7ed3\u679c\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5148\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u788e\u7247\u7684\u6444\u53d6\u80fd\u8bf1\u5bfc\u51famregDC\u8868\u578b\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u4f1a\u4e2d\u6b62\u66f4\u591a\u788e\u7247\u7684\u6444\u53d6\uff0c\u540c\u65f6\u5f15\u53d1\u4e86\u5bf9\u83b7\u53d6\u5230\u7684cargo\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u3002\u5c3d\u7ba1\u8fd9\u4e2a\u8f6c\u53d8\u8fc7\u7a0b\u4e0e\u4f17\u591a\u5df2\u77e5\u7684\u8c03\u63a7\u7ec6\u80de\u8fc1\u79fb\u7684\u5206\u5b50\u65e0\u5173\uff0c\u4f46mregDCs\u5b58\u5728\u4e8e\u6b63\u5e38\u548c\u708e\u75c7\u7ec4\u7ec7\u4e2d\uff0c\u5e76\u8868\u73b0\u51fa\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Merad\u7684\u62a5\u544a\u6307\u51fa\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6210\u719f\u4f9d\u8d56\u4e8e\u80c6\u56fa\u9187\u5411\u7ec6\u80de\u8868\u9762\u7684\u8fd0\u52a8\uff0c\u6291\u5236\u80c6\u56fa\u9187\u7684\u8f6c\u8fd0\u4f1a\u964d\u4f4e\u5176\u6210\u719f\u3002\u5979\u7684\u56e2\u961f\u53d1\u73b0\uff0c\u809d\u7ec6\u80de\u764c\u4e2d\u7684mregDCs\u5728\u75c5\u7076\u4e2d\u7684\u6570\u91cf\u504f\u9ad8\uff0c\u800c\u4e14\u5b83\u4eec\u7684\u80c6\u56fa\u9187\u5408\u6210\u80fd\u529b\u4e5f\u66f4\u5f3a\u3002\u8fd9\u4e9bmregDCs\u5728\u75c5\u7076\u4e2d\u7684\u5b58\u5728\uff0c\u901a\u8fc7\u4e0e\u514d\u75ab\u8c03\u8282\u6027T\u7ec6\u80de\u5171\u4eab\u7684\u914d\u4f53\uff0c\u80fd\u591f\u6291\u5236T\u7ec6\u80de\u7684\u6d3b\u6027\u3002\u8fd9\u9879\u53d1\u73b0\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u6cbb\u7597\u601d\u8def\uff1a\u901a\u8fc7\u6291\u5236mregDCs\u7684\u80c6\u56fa\u9187\u5408\u6210\u80fd\u529b\uff0c\u53ef\u80fd\u53ef\u4ee5\u4f7fT\u7ec6\u80de\u7684\u53cd\u5e94\u6027\u6062\u590d\uff0c\u4ece\u800c\u589e\u5f3a\u514d\u75ab\u7597\u6cd5\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4.\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u673a\u5236\u57fa\u7840<\/strong><\/p>\n

Ira Mellman – \u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u65e7\u91d1\u5c71\u5e02Genentech\u516c\u53f8<\/span><\/strong><\/p>\n<\/section>\n

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\u764c\u75c7\u514d\u75ab\u5468\u671f\u662f\u63cf\u8ff0\u751f\u6210\u548c\u7ef4\u6301\u5bf9\u80bf\u7624\u7684\u81ea\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u5173\u952e\u6b65\u9aa4\u7684\u4e00\u4e2a\u7406\u8bba\u3002\u8fd9\u4e2a\u7406\u8bba\u4e5f\u5e2e\u52a9\u6211\u4eec\u627e\u51fa\u53ef\u80fd\u7834\u574f\u6709\u6548\u514d\u75ab\u53cd\u5e94\u7684\u5173\u952e\u73af\u8282\uff0c\u4ee5\u4fbf\u8fdb\u884c\u5e72\u9884\u548c\u4fee\u6b63\u3002Ira Mellman\u9996\u5148\u501f\u52a9\u8fd9\u4e2a\u5468\u671f\uff0c\u89e3\u91ca\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5982\u4f55\u901a\u8fc7T\u7ec6\u80de\u4ea7\u751f\u6297\u80bf\u7624\u53cd\u5e94\uff0c\u4ee5\u53caT\u7ec6\u80de\u5982\u4f55\u6df1\u53d7\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff08TIME\uff09\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76\u5df2\u7ecf\u8bc1\u5b9e\uff0c\u957f\u671f\u7684\u80bf\u7624\u6297\u539f\u66b4\u9732\u6700\u7ec8\u4f1a\u5bfc\u81f4\u529f\u80fd\u4e0d\u5168\u4e14\u5bff\u547d\u77ed\u7684\u201c\u8017\u7aed\u201dT\u7ec6\u80de\u7684\u4ea7\u751f\u3002\u4eba\u4eec\u66fe\u7ecf\u4ee5\u4e3a\u6297PD-1\u8f74\u7597\u6cd5\u80fd\u9006\u8f6c\u6216\u9884\u9632T\u7ec6\u80de\u8017\u7aed\uff0c\u4f46\u5bf9\u8017\u7aed\u7684\u8868\u89c2\u9057\u4f20\u5b66\u7684\u7406\u89e3\u4f7f\u5f97\u8fd9\u79cd\u89c2\u70b9\u65e0\u6cd5\u6210\u7acb\u3002\u73b0\u5728\uff0c\u4eba\u4eec\u8ba4\u4e3a\u65e9\u671f\u4e2d\u65ad\u6291\u5236\u6027PD-1\u8f74\u529f\u80fd\u53ef\u4ee5\u5bfc\u81f4\u66f4\u591a\u65b0\u751fT\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u6539\u5584\u5206\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0cPD-1\u4fe1\u53f7\u963b\u65ad\u4e86\u5173\u952e\u7684CD28\u5171\u523a\u6fc0\u4fe1\u53f7\uff0cPD-L1\u9633\u6027\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u5bf9\u6297PD-1\u8f74\u7684\u6548\u5e94\u975e\u5e38\u5173\u952e\u3002Mellman\u8fdb\u4e00\u6b65\u63cf\u8ff0\u4e86\u4ed6\u8fd1\u671f\u7684\u5de5\u4f5c\uff0c\u4ed6\u53d1\u73b0TIGIT\u662fCD226\u5171\u523a\u6fc0\u53d7\u4f53\u7684\u5185\u6e90\u6027\u7ade\u4e89\u7269\uff0c\u963b\u65ad\u5176\u5bf9PVR\uff08CD226\u7684\u6fc0\u6d3b\u914d\u4f53\uff09\u7684\u963b\u65ad\u53ef\u4ee5\u963b\u6b62\u6700\u5927\u7a0b\u5ea6\u7684T\u7ec6\u80de\u523a\u6fc0\u3002\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\u540c\u65f6\u963b\u65ad\u4e24\u6761\u901a\u8def\u5c06\u662f\u6700\u4f73\u9009\u62e9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u8054\u5408PD-L1\u548cTIGIT\u963b\u65ad\u57282\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u63d0\u9ad8\u603b\u751f\u5b58\u7387\u7684\u53ef\u80fd\uff0c\u76ee\u524d\u6b63\u5728\u7b49\u5f853\u671f\u7814\u7a76\u7684\u6700\u7ec8\u7ed3\u679c\u3002\u673a\u5236\u4e0a\uff0c\u8054\u5408\u963b\u65ad\u80fd\u663e\u8457\u4e0a\u8c03CD226\uff0c\u5e76\u5728\u7279\u5f02\u6027\u6297\u539f\u548c\u5927\u91cf\u7684CD8+<\/sup> T\u7ec6\u80de\u4e2d\u4e0b\u8c03TOX\uff0c\u4ece\u800c\u6539\u5584\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684\u8d28\u91cf\u3002TOX\u7684\u8868\u8fbe\u964d\u4f4e\u9700\u8981CD226\u4fe1\u53f7\u4f20\u5bfc\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5927\u89c4\u6a21\u7684\u5355\u7ec6\u80de\u5206\u6790\u6e05\u6670\u5730\u63cf\u8ff0\u4e86\u591a\u79cdT\u7ec6\u80de\u72b6\u6001\u548c\u5173\u952e\u6807\u8bb0\u7269\uff0c\u5305\u62ec\u4f4d\u4e8e\u4ece\u5e7c\u7a1a\u7ec6\u80de\u5230\u6b7b\u4ea1\u7ec6\u80de\u8fde\u7eed\u8c31\u4e0a\u7684\u7ec6\u80de\uff0c\u5982\u6807\u8bb0\u4e3aSlamf6\u7684T\u5e72\u7ec6\u80de\u8bb0\u5fc6\u7ec6\u80de\uff0c\u6807\u8bb0\u4e3a\u5e72\u6270\u7d20\u9014\u5f84\u7684\u6548\u5e94\u7ec6\u80de\uff0c\u6807\u8bb0\u4e3aCCL5\u7684\u4e34\u65f6\u6548\u5e94\u6837\u7ec6\u80de\uff0c\u4ee5\u53ca\u4e00\u7fa4\u665a\u671f\u6548\u5e94\u5668\/\u8017\u7aed\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TCR\u6d4b\u5e8f\u7684\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u540c\u65f6\u963b\u65adPD-L1\u548cTIGIT\u80fd\u663e\u8457\u589e\u5f3a\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u5728\u5f15\u6d41\u6dcb\u5df4\u7ed3\uff08dLN\uff09\u3001\u8840\u6db2\u548c\u80bf\u7624\u4e2d\u7684\u6570\u91cf\u3002\u9006\u65f6\u5e8f\u5206\u6790\u63ed\u793a\uff0c\u867d\u7136\u5355\u4e2a\u68c0\u67e5\u70b9\u7597\u6cd5\u6709\u4e00\u5b9a\u7684\u6539\u5584\uff08\u4f8b\u5982\u5728dLN\u4e2d\u589e\u52a0\u6548\u5e94\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u4fc3\u8fdb\u6548\u5e94\u7ec6\u80de\u4ecedLN\u5411\u80bf\u7624\u8fc1\u79fb\uff0c\u4ee5\u53ca\u51cf\u5c11\u8017\u7aed\u7684\u7ec6\u80de\u7ec4\u5206\uff09\uff0c\u4f46\u662f\u8054\u5408\u963b\u65adPD-L1\u548cTIGIT\u53ef\u4ee5\u8fdb\u4e00\u6b65\u4f18\u5316\u8fd9\u4e9b\u5f71\u54cd\u3002\u8fd9\u79cd\u8054\u5408\u963b\u65ad\u5bfc\u81f4TSCM\u548cT\u6548\u5e94\u6837\u7ec6\u80de\u5728dLN\u4e2d\u7684\u6269\u589e\uff0c\u5e76\u4f7f\u5177\u6709\u591a\u79cd\u529f\u80fd\u7684\u5be1\u514b\u9686\u7ec6\u80de\u901a\u8fc7\u8840\u6db2\u8fdb\u5165\u80bf\u7624\u3002\u5728\u80bf\u7624\u5185\u90e8\uff0c\u4ed6\u4eec\u89c2\u5bdf\u5230\u6548\u5e94\u8bb0\u5fc6\u7ec6\u80de\u548cCTLs\u7684\u51fa\u73b0\uff0c\u4f46\u5b83\u4eec\u6700\u7ec8\u5206\u5316\u6210\u7ec8\u672b\u8017\u7aed\u7ec6\u80de\u7684\u7a0b\u5ea6\u6709\u9650\u3002\u8fd9\u79cd\u6709\u9650\u7684\u8017\u7aed\u5206\u5316\u4f3c\u4e4e\u4f9d\u8d56\u4e8e\u5171\u523a\u6fc0\u901a\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u521d\u6b65\u6570\u636e\u663e\u793a\uff0cTIGIT\u6297\u4f53\u4e0a\u7684Fc\u7ed3\u6784\u57df\u53ef\u80fd\u5bf9\u9ad3\u7cfb\u7ec6\u80de\u4ea7\u751f\u4fe1\u53f7\u4f5c\u7528\uff0c\u4f7f\u5176\u5206\u6ccc\u4fc3\u708e\u56e0\u5b50\uff0c\u9650\u5236Treg\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5e76\u6fc0\u6d3bNK\u7ec6\u80de\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\u53ef\u80fd\u5b58\u5728\u591a\u6761\u6d3b\u8dc3\u7684\u901a\u8def\uff0c\u8fd9\u4e0e\u6211\u4eec\u4ece2\u671f\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c\u4e2d\u83b7\u53d6\u7684\u751f\u7269\u6807\u5fd7\u7269\u6570\u636e\u76f8\u543b\u5408\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u540e\uff0cMellman\u63cf\u8ff0\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u9ad8\u901a\u91cf\u5b9e\u9a8c\u65b9\u6cd5\uff08\u5373\u5c06\u53d1\u8868\uff09\uff0c\u8be5\u65b9\u6cd5\u5728\u5c0f\u9f20\u8033\u6735\u4e0a\u521b\u5efa\u4e86\u4e00\u7cfb\u5217\u53ef\u4ee5\u79cd\u690d\u80bf\u7624\u7ec6\u80de\u7684”\u4e95”\u3002\u53ef\u4ee5\u5206\u522b\u76d1\u6d4b\u6bcf\u4e2a”\u4e95”\u4e2d\u7ec6\u80de\u7684\u751f\u957f\uff0c\u5e76\u53ef\u4ee5\u6d4b\u8bd5\u68c0\u67e5\u70b9\u963b\u65ad\u6216\u6dfb\u52a0\u751f\u957f\u56e0\u5b50\u7b49\u5e72\u9884\u63aa\u65bd\u7684\u6548\u679c\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u4e0d\u540c\u7684\u80bf\u7624\u7ec6\u80de\u682a\u5728\u690d\u5165\u65f6\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u884c\u4e3a\uff0c\u8fd9\u8868\u660e\u80bf\u7624\u7ec6\u80de\u53ef\u80fd\u5177\u6709\u81ea\u4e3b\u7684\u6548\u5e94\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5373\u4f7f\u4f7f\u7528\u540c\u4e00\u79cd\u80bf\u7624\u7ec6\u80de\u6837\u672c\u8fdb\u884c\u79cd\u690d\uff0c\u4e0d\u540c”\u4e95”\u4e4b\u95f4\u7684\u80bf\u7624\u7ec6\u80de\u751f\u957f\u548cT\u7ec6\u80de\u6d78\u6da6\u4e5f\u5b58\u5728\u5dee\u5f02\u3002\u8fd9\u8868\u660e\u5c40\u90e8\u7ec6\u80de\u73af\u5883\u5728\u80bf\u7624\u751f\u957f\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5c3d\u7ba1\u6240\u6709\u7684”\u4e95”\u90fd\u53d7\u5230\u4e86\u7c7b\u4f3c\u7684T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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5.<\/strong>\u63ed\u793a\u80f0\u817a\u764c\u5bf9T\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\u7684\u80bf\u7624\u5185\u5728\u62b5\u6297\u673a\u5236<\/strong><\/p>\n

Judit D\u00edaz-G\u00f3mez – \u5df4\u585e\u7f57\u90a3Vall d’Hebron\u80bf\u7624\u7814\u7a76\u6240\uff08VHIO\uff09<\/span><\/strong><\/p>\n<\/section>\n

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\u4e3a\u4e86\u627e\u5230\u53ef\u80fd\u4f7f\u80f0\u817a\u764c\u5bf9\u514d\u75ab\u7597\u6cd5\u66f4\u654f\u611f\u7684\u65b0\u9014\u5f84\uff0cJudit Diaz-Gomez\u53ca\u5176\u56e2\u961f\u5229\u7528\u5168\u57fa\u56e0\u7ec4\u7684CRISPR\/Cas9\u6572\u9664\u7b5b\u9009\u6280\u672f\uff0c\u5bfb\u627e\u9650\u5236\u7279\u5f02\u6027\u65b0\u6297\u539fTCR\u8f6c\u5bfcT\u7ec6\u80de\u6740\u4f24\u60a3\u8005\u6e90\u80f0\u817a\u764c\u7ec6\u80de\u7cfbTCL-4177\u7684\u57fa\u56e0\u3002\u4ed6\u4eec\u4e3b\u8981\u5173\u6ce8\u90a3\u4e9b\u5728\u88ab\u6572\u9664\u540e\uff0c\u80fd\u589e\u5f3aT\u7ec6\u80de\u6740\u4f24\u6548\u5e94\u7684\u57fa\u56e0\u3002\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e8635\u4e2a\u80fd\u591f\u6291\u5236T\u7ec6\u80de\u4ecb\u5bfc\u7684\u6740\u4f24\u6548\u5e94\u7684\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4ee5\u524d\u5e76\u672a\u88ab\u7814\u7a76\u8fc7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c06\u8fd9\u4e9b\u57fa\u56e0\u7ed8\u5236\u5728\u5168\u86cb\u767d\u7ec4\u5206\u6790\u7f51\u7edc\u4e2d\uff0c\u4ed6\u4eec\u53d1\u73b0\u81ea\u566c\u548c\u6cdb\u7d20\u5316\u9014\u5f84\u3001\u67d3\u8272\u8d28\u91cd\u5851\u3001\u56ca\u6ce1\u8f6c\u8fd0\u3001\u86cb\u767d\u8d28\u6298\u53e0\u4ee5\u53caESCRT\u590d\u5408\u4f53\u90fd\u53c2\u4e0e\u4e86\u80bf\u7624\u7684\u5185\u5728\u62b5\u6297\u673a\u5236\u3002\u76ee\u524d\u4e3a\u6b62\uff0c\u4ed6\u4eec\u5df2\u7ecf\u72ec\u7acb\u9a8c\u8bc1\u4e8610\u4e2a\u6d89\u53ca\u56db\u4e2a\u4e0d\u540c\u9014\u5f84\u7684\u57fa\u56e0\u4e2d\u76847\u4e2a\uff0c\u5e76\u4e14\u53d1\u73b0\u6c89\u9ed8\u5176\u4e2d\u56db\u4e2a\u57fa\u56e0\u80fd\u589e\u5f3aT\u7ec6\u80de\u5bf9\u53e6\u4e00\u79cd\u80f0\u817a\u80bf\u7624\u7ec6\u80de\u7cfbTCL-CABA\u7684\u6740\u4f24\u6548\u5e94\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u5177\u6709\u4e0d\u540c\u7684\uff08\u672a\u77e5\uff09\u7279\u5f02\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5176\u4e2d\u6700\u6709\u524d\u666f\u7684\u5019\u9009\u57fa\u56e0ITGB1\u548cMARCH5\u5df2\u7ecf\u5728\u4e34\u5e8a\u6570\u636e\u4e2d\u5f97\u5230\u4e86\u56de\u987e\u6027\u5206\u6790\uff0c\u7ed3\u679c\u663e\u793a\uff0cITGB1\u6216MARCH5\u7684\u4f4e\u8868\u8fbe\u4e0e\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u60a3\u8005\u7684\u603b\u4f53\u751f\u5b58\u7387\u6539\u5584\u6709\u5173\u3002\u76ee\u524d\uff0c\u4ed6\u4eec\u6b63\u5728\u5bf9\u66f4\u591a\u7684\u5019\u9009\u57fa\u56e0\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u548c\u9a8c\u8bc1\uff0c\u5e76\u8fdb\u884c\u76f8\u5173\u7684\u673a\u7406\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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6.CLN-617\u662f\u4e00\u79cd\u9996\u521b\u7684\u878d\u5408\u86cb\u767d\uff0c\u80fd\u5728\u6ce8\u5c04\u7684\u80bf\u7624\u4e2d\u7279\u5f02\u6027\u4fdd\u7559IL-2\u548cIL-12\uff0c\u5e76\u5f3a\u529b\u89e6\u53d1\u5168\u8eab\u6027\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94<\/span><\/strong><\/p>\n

Naveen Mehta – Cullinan Oncology, \u7f8e\u56fd\u5251\u6865<\/span><\/strong><\/p>\n<\/section>\n

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\u591a\u9879\u8bc1\u636e\u8868\u660e\uff0cIL-2 \u548c IL-12 \u4e0d\u4ec5\u662f\u5f3a\u5927\u7684\u6297\u80bf\u7624\u7ec6\u80de\u56e0\u5b50\uff0c\u4e14\u5728\u4fe1\u53f7\u901a\u8def\u4e0a\u662f\u76f8\u8054\u7cfb\u7684\uff0c\u540c\u65f6\u5b83\u4eec\u7684\u6d3b\u6027\u4e5f\u662f\u534f\u540c\u7684\u3002\u7136\u800c\uff0c\u5f53\u5b83\u4eec\u5728\u4e34\u5e8a\u4e0a\u901a\u8fc7\u5168\u8eab\u7ed9\u836f\u65f6\uff0c\u5404\u81ea\u90fd\u4f1a\u53d7\u5230\u6bd2\u6027\u7684\u9650\u5236\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u9650\u5236\uff0c\u7814\u7a76\u4eba\u5458\u6839\u636e\u4e09\u4e2a\u539f\u5219\u8bbe\u8ba1\u4e86 CLN-617\uff1a\uff081\uff09\u7ec6\u80de\u56e0\u5b50\u4e3b\u8981\u4ee5\u81ea\u5206\u6ccc\/\u65c1\u5206\u6ccc\u7684\u65b9\u5f0f\u8d77\u4f5c\u7528\uff0c\u56e0\u6b64\u5e94\u8fdb\u884c\u5c40\u90e8\u7ed9\u836f; \uff082\uff09\u5c40\u90e8\u6ce8\u5c04\u7684\u7ec6\u80de\u56e0\u5b50\u9700\u8981\u8fdb\u884c\u4fee\u6539\u4ee5\u9650\u5236\u5168\u8eab\u66b4\u9732\u5e76\u589e\u5f3a\u4fdd\u7559\u6548\u679c; \uff083\uff09\u7ec6\u80de\u56e0\u5b50\u901a\u5e38\u4e0e\u5176\u4ed6\u7ec6\u80de\u56e0\u5b50\u534f\u540c\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u4ed6\u4eec\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5355\u5206\u5b50\uff0c\u8be5\u5206\u5b50\u7f16\u7801\u672a\u4fee\u9970\u7684\u4eba\u6e90 IL-2 \u548c IL-12\uff0c\u5e76\u4e0e\u80f6\u539f\u7ed3\u5408\u57df\uff08hLAIR2\uff09\u548c\u4eba\u8840\u6e05\u767d\u86cb\u767d\u94fe\u63a5\uff0c\u4ee5\u5728\u80bf\u7624\u4e2d\u4fdd\u7559\u6ce8\u5c04\u7684 CLN-617\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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