{"id":5209,"date":"2023-06-30T00:00:12","date_gmt":"2023-06-29T16:00:12","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/06\/30\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%8d%a1%e4%bb%8b%e8%8b%97%e5%92%8c%e6%8a%97pd-l1%e6%8a%97%e4%bd%93%e5%9c%a8%e8%86%80%e8%83%b1%e8%82%bf%e7%98%a4%e4%b8%ad-2\/"},"modified":"2023-06-30T00:00:12","modified_gmt":"2023-06-29T16:00:12","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%8d%a1%e4%bb%8b%e8%8b%97%e5%92%8c%e6%8a%97pd-l1%e6%8a%97%e4%bd%93%e5%9c%a8%e8%86%80%e8%83%b1%e8%82%bf%e7%98%a4%e4%b8%ad-2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/06\/30\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%8d%a1%e4%bb%8b%e8%8b%97%e5%92%8c%e6%8a%97pd-l1%e6%8a%97%e4%bd%93%e5%9c%a8%e8%86%80%e8%83%b1%e8%82%bf%e7%98%a4%e4%b8%ad-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c22\u7ae0\uff1a\u5361\u4ecb\u82d7\u548c\u6297PD-L1\u6297\u4f53\u5728\u8180\u80f1\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\uff08\u4e0b\uff09"},"content":{"rendered":"<div class='wxsyncmain'>\n<section style=\"font-size: 16px;\">\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.5583333333333333\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-b3d9c9760ec1a224f36311e2a4ffdd56.png\"  \/><\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(51, 122, 183);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><a target=\"_blank\" href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456254876&amp;idx=1&amp;sn=f90d408389224900871bbbadf1db7578&amp;chksm=8d74a65dba032f4bb9d892ad021d9f6ad4d875c28349e0d9c03bf53503963e43fcac836613ef&amp;scene=21#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c22\u7ae0\uff1a\u5361\u4ecb\u82d7\u548c\u6297PD-L1\u6297\u4f53\u5728\u8180\u80f1\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" data-itemshowtype=\"0\" tab=\"innerlink\" data-linktype=\"2\" rel=\"noopener\">\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c22\u7ae0\uff1a\u5361\u4ecb\u82d7\u548c\u6297PD-L1\u6297\u4f53\u5728\u8180\u80f1\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">22.3.3&nbsp;&nbsp; PD-1 \u548c PD-L1 \u6291\u5236\u5242\u4f1a\u6539\u53d8\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u80bf\u7624\u7684\u62a4\u7406\u6807\u51c6<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7814\u7a76\u4eba\u5458\u57fa\u4e8e\u65e9\u671f\u7814\u7a76\u6570\u636e\u8fdb\u884c\u4e86\u4e24\u9879\u5927\u578b3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u6bd4\u8f83\u963f\u66ff\u5229\u73e0\u5355\u6297\u6216\u6d3e\u59c6\u5355\u6297\u4e0e\u5316\u7597\u5728\u8f6c\u79fb\u6027\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u7597\u6548\u3002\u8fd9\u4e9b\u7814\u7a76\u4e3b\u8981\u5173\u6ce8\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u548cPD-L1\u9633\u6027\u60a3\u8005\u5728\u4e8c\u7ebf(2L)\u6216\u4e09\u7ebf(3L)\u6cbb\u7597\u4e2d\u7684\u603b\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(PFS)\u3002<\/p>\n<p style=\"white-space: normal;\">\u5176\u4e2d\uff0c2016\u5e74\u62a5\u5bfc\u7684KEYNOTE-045\u8bd5\u9a8c\u5728542\u4f8b\u60a3\u8005\u4e2d\u6bd4\u8f83\u4e86\u6d3e\u59c6\u5355\u6297\u4e0e\u5316\u7597\uff08\u6587\u592b\u5362\u5b81\u3001\u7d2b\u6749\u9187\u6216\u591a\u70ef\u7d2b\u6749\u9187\uff09\u7684\u7597\u6548\u3002\u5728\u4e8c\u6b21\u4e2d\u671f\u5206\u6790\u65f6\uff0c\u4e2d\u4f4d\u968f\u8bbf14.1\u4e2a\u6708\u540e\uff0c\u6d3e\u59c6\u5355\u6297\u7ec4\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a10.3\u4e2a\u6708\uff0895% CI: 8-11.8\uff09\uff0c\u800c\u5316\u7597\u7ec4\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a7.4\u4e2a\u6708\uff0895% IC: 6.1-8.3\uff09\u3002\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8627%\uff08HR: 0.73, 95% CI: 0.59-0.91, p = 0.0022\uff09\u3002<\/p>\n<p style=\"white-space: normal;\">\u5f53\u96c6\u4e2d\u5206\u6790\u80bf\u7624\u548c\u5468\u56f4\u514d\u75ab\u7ec6\u80de\u4e0aPD-L1\u8868\u8fbe\u6c34\u5e73\u7684\u8054\u5408\u8bc4\u5206(CPS)\u226510%\u7684\u60a3\u8005\u65f6\uff0c\u6d3e\u59c6\u5355\u6297\u548c\u5316\u7597\u836f\u7269\u7684\u6b7b\u4ea1\u98ce\u9669\u5dee\u5f02\u66f4\u5927\uff08HR\uff1a0.57\uff0cCI 95%\uff1a0.37-0.88\uff0cP=0.0048\uff09\uff0c\u4f46\u4e24\u79cd\u836f\u7269\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u6ca1\u6709\u663e\u793a\u51fa\u5dee\u5f02\u3002\u6d3e\u59c6\u5355\u6297\u7684\u6cbb\u7597\u7f13\u89e3\u7387\u63a5\u8fd120%\uff0821.1%\uff09\uff0c\u660e\u663e\u4f18\u4e8e\u5316\u7597\uff0811.4%\uff09\uff0c\u4e14\u7f13\u89e3\u6548\u679c\u6301\u4e45\u3002CPS\u226510%\u5e76\u672a\u8868\u73b0\u51fa\u66f4\u597d\u7684\u7f13\u89e3\u7387\u3002<\/p>\n<p style=\"white-space: normal;\">\u5728KEYNOTE-045\u8bd5\u9a8c\u4e2d\uff0c\u53ea\u670915%\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u53d1\u751f3-5\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5176\u4e2d4\u4f8b\u6b7b\u4ea1\u4e0e\u6d3e\u59c6\u5355\u6297\u6709\u5173\u3002\u8fd9\u662f\u7b2c\u4e00\u4e2a\u8bc1\u660ePD-1\/PD-L1\u6291\u5236\u5242\u5bf9\u5c3f\u8def\u4e0a\u76ae\u764c\u5177\u6709\u7597\u6548\u7684\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u30022017\u5e74\uff0c\u6d3e\u59c6\u5355\u6297\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u7684\u4e8c\u7ebf\u548c\u4e09\u7ebf\u6cbb\u7597\u4e2d\u3002<\/p>\n<p style=\"white-space: normal;\">\u81f3\u4e8e\u5c06\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e0e\u4e8c\u7ebf\u6216\u4e09\u7ebf\u5316\u7597\u8fdb\u884c\u6bd4\u8f83\u76843\u671f\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5c06\u4f1a\u57282017\u5e74\u516c\u5e03\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">22.3.4 &nbsp;\u6211\u4eec\u53ef\u4ee5\u7b5b\u9009\u51fa\u54ea\u4e9b\u60a3\u8005\u66f4\u6709\u53ef\u80fd\u5bf9PD-1\u548cPD-L1\u6291\u5236\u5242\u4f5c\u51fa\u53cd\u5e94\u5417\uff1f<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u867d\u7136PD-1\u548cPD-L1\u6291\u5236\u5242\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027UC\uff0c\u4f46\u53ea\u670920%\u7684\u60a3\u8005\u4f1a\u5bf9\u68c0\u67e5\u70b9\u963b\u65ad\u514d\u75ab\u7597\u6cd5\u4ea7\u751f\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u4e3a\u4e86\u66f4\u6709\u6548\u5730\u5e94\u7528\u514d\u75ab\u7597\u6cd5\u6cbb\u7597\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\uff0c\u6211\u4eec\u9700\u8981\u91c7\u53d6\u4e00\u4e9b\u7b56\u7565\u3002\u7b2c\u4e00\u4e2a\u7b56\u7565\u662f\u7b5b\u9009\u53ef\u80fd\u4f1a\u5bf9\u8fd9\u4e9b\u836f\u7269\u4ea7\u751f\u53cd\u5e94\u7684\u60a3\u8005\u3002\u4e0e\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\u4e00\u6837\uff0c\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u5728\u63a2\u7d22\u53ef\u80fd\u9884\u6d4b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u7597\u6548\u7684\u56e0\u7d20\u3002\u7136\u800c\uff0c\u76ee\u524d\u7684\u7814\u7a76\u7ed3\u679c\u5e76\u4e0d\u4e00\u81f4\uff0c\u56e0\u6b64\u65e0\u6cd5\u8fdb\u884c\u51c6\u786e\u9884\u6d4b\u3002\u4f8b\u5982\uff0c\u80bf\u7624\u7c7b\u578b\uff08\u5982\u8180\u80f1\u764c\/\u4e0a\u547c\u5438\u9053\u75be\u75c5\uff09\u3001\u6027\u522b\uff08\u7537\u6027\/\u5973\u6027\uff09\u4ee5\u53ca\u65e2\u5f80\u6cbb\u7597\u8def\u7ebf\u7684\u6570\u91cf\u90fd\u4e0e\u7597\u6548\u65e0\u5173\u3002\u4e0d\u8fc7\uff0c\u6839\u636eKEYNOTE-045\u8bd5\u9a8c\u7684\u62a5\u544a\uff0c\u5438\u70df\u8005\u66f4\u6709\u53ef\u80fd\u4ece\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u4e2d\u53d7\u76ca\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u6ca1\u6709\u5176\u4ed6\u7814\u7a76\u8868\u660e\u5438\u70df\u4e0e\u9884\u6d4b\u60a3\u8005\u7684\u7597\u6548\u6709\u5173\u3002\u6b64\u5916\uff0c\u8f6c\u79fb\u6027\u80bf\u7624\u7684\u90e8\u4f4d\u4e0e\u7597\u6548\u4e5f\u6709\u5173\u7cfb\u3002\u53ea\u6709\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u7684\u60a3\u8005\u5bf9PD-1\u548cPD-L1\u6291\u5236\u5242\u7684\u53cd\u5e94\u7387\u9ad8\u4e8e\u5185\u810f\u8f6c\u79fb\u7684\u60a3\u8005\u3002\u8fd9\u4e5f\u5f15\u53d1\u4e86\u4e00\u4e2a\u95ee\u9898\uff0c\u5373\u7279\u5b9a\u7684\u80bf\u7624\u90e8\u4f4d\u5fae\u73af\u5883\u662f\u5426\u53ef\u4ee5\u5728\u9884\u6d4b\u7597\u6548\u65b9\u9762\u53d1\u6325\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u786e\u5b9a\u9884\u6d4b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6548\u7684\u5408\u9002\u56e0\u7d20\uff0c\u5e76\u5e2e\u52a9\u66f4\u591a\u7684\u60a3\u8005\u4ece\u514d\u75ab\u7597\u6cd5\u4e2d\u53d7\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u76ee\u524d\u5df2\u7ecf\u53d1\u73b0\u4e86\u8bb8\u591a\u6f5c\u5728\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7528\u4e8e\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u3002\u8fd9\u4e9b\u6807\u5fd7\u7269\u5305\u62ec\u57fa\u4e8e\u5fae\u73af\u5883\u548c\u57fa\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u6807\u5fd7\u7269<span style=\"color: rgb(203, 47, 21);\">\uff08Table 22.2)<\/span>\u3002\u6700\u5148\u8fdb\u7684\u9884\u6d4bPD-1\u548cPD-L1\u6291\u5236\u5242\u7597\u6548\u7684\u751f\u7269\u6807\u5fd7\u7269\u5305\u62ec\u7a81\u53d8\u8d1f\u8377\u3001\u80bf\u7624\u6216\u514d\u75ab\u7ec6\u80dePD-L1\u7684\u8868\u8fbe\u6c34\u5e73\u4ee5\u53ca\u80bf\u7624\u5185\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u7a0b\u5ea6\u3002\u76ee\u524d\uff0cPD-1\u548cPD-L1\u7684\u8868\u8fbe\u91cf\u5c1a\u672a\u88ab\u8ba4\u4e3a\u662f\u53ef\u9760\u4e14\u53ef\u590d\u5236\u7684\u6807\u5fd7\u7269\uff0c\u7528\u4e8e\u9884\u6d4b\u5176\u7597\u6548\u6216\u673a\u4f53\u5bf9\u5176\u8010\u836f\u6027\u3002\u5728\u4e8c\u7ebf\u6cbb\u7597\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\u6216\u514d\u75ab\u7ec6\u80de\u4e0a\u7684PD-L1\u8868\u8fbe\u4e0e\u673a\u4f53\u5bf9PD-1\/PD-L1\u6291\u5236\u5242\u7684\u53cd\u5e94\u5b58\u5728\u76f8\u5173\u6027\uff0c\u4f46\u6b64\u76f8\u5173\u6027\u5c1a\u4e0d\u8db3\u4ee5\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u5e94\u7528\u3002<\/p>\n<p style=\"white-space: normal;\">\u4f7f\u7528PD-1\/PD-L1\u67d3\u8272\u7684\u4e00\u4e2a\u4e3b\u8981\u7f3a\u70b9\u662f\u514d\u75ab\u7ec4\u5316PD-L1\u9633\u6027\u7684\u8bc4\u4f30\u65b9\u6cd5\u5b58\u5728\u5f02\u8d28\u6027\u3002\u76ee\u524d\uff0c\u4e0d\u540c\u7684\u6297\u4f53\u5236\u9020\u5546\u5df2\u7ecf\u5f00\u53d1\u51fa\u591a\u79cd\u4e0d\u540c\u7684\u68c0\u6d4b\u65b9\u6cd5\u4f5c\u4e3a\u8f85\u52a9\u8bca\u65ad\u3002\u8bc4\u4f30PD-L1\u7684\u6297\u4f53\u5177\u6709\u4e0d\u540c\u7684\u7279\u6027\uff0c\u8fd9\u5f71\u54cd\u4e86\u4e0d\u540c\u7814\u7a76\u95f4\u7684\u6bd4\u8f83\u3002\u6b64\u5916\uff0c\u8fd8\u5b58\u5728\u8bb8\u591a\u672a\u89e3\u51b3\u7684\u95ee\u9898\uff0c\u4f8b\u5982PD-L1\u9633\u6027\u67d3\u8272\u7684\u754c\u5b9a\u6807\u51c6\u3002\u5927\u591a\u6570\u7814\u7a76\u8ba4\u4e3a\uff0c\u5728\u80bf\u7624\u7ec6\u80de\u6216\u514d\u75ab\u7ec6\u80de\u4e2d\uff0cPD-L1\u67d3\u8272\u7684\u7ec6\u80de\u6570\u5e94\u8be5\u5927\u4e8e5%\uff08IHC\u67d3\u8272\u8bc4\u52062\/3\uff09\u624d\u80fd\u5224\u65ad\u4e3aPD-L1\u9633\u6027\uff0c\u4f46\u4e5f\u6709\u5176\u4ed6\u7814\u7a76\u8ba4\u4e3a\u5927\u4e8e1%\u5373\u4e3a\u9633\u6027\u754c\u9650\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u5176\u4ed6\u8bca\u65ad\u6765\u8f85\u52a9\u8bca\u65ad\u3002\u84dd\u56fe\u8ba1\u5212\u5c06\u6709\u52a9\u4e8e\u5728\u6279\u51c6\u524d\u9636\u6bb5\u4e3aPD-1\/PD-L1\u8f85\u52a9\u8bca\u65ad\u7279\u5f81\u5efa\u7acb\u8bc1\u636e\u57fa\u7840\u3002\u4e00\u65e6\u6d4b\u8bd5\u88ab\u6279\u51c6\uff0c\u4ea7\u751f\u7684\u4fe1\u606f\u53ef\u4ee5\u4e3a\u6279\u51c6\u540e\u7684\u7814\u7a76\u5960\u5b9a\u57fa\u7840\uff0c\u5e2e\u52a9\u60a3\u8005\u3001\u533b\u751f\u548c\u75c5\u7406\u5b66\u5bb6\u51b3\u5b9a\u5982\u4f55\u6700\u597d\u5730\u5229\u7528\u6d4b\u8bd5\u7ed3\u679c\u505a\u51fa\u6cbb\u7597\u51b3\u7b56\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.8331318016928658\" data-s=\"300,640\"  data-type=\"png\" data-w=\"827\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-46639d33d37fcfe3288c89a8650aa473.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\" powered-by=\"xiumi.us\">\n<p><span style=\"color: rgb(203, 47, 21);\">Table 22.2<\/span>&nbsp;\u76ee\u524d\u5728UC\u4e2d\u8bc4\u4f30\u9884\u6d4bPD1\u6216PD-L1\u963b\u65ad\u53cd\u5e94\u7684\u5173\u952e\u751f\u7269\u6807\u5fd7\u7269\u3002IHC, \u514d\u75ab\u7ec4\u5316\uff1bTCGA, \u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff1bTCR, T\u7ec6\u80de\u53d7\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6839\u636e\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31(TCGA)\u7684\u5206\u7c7b\uff0c\u5c3f\u8def\u4e0a\u76ae\u764c\u5b58\u5728\u6cbb\u7597\u6548\u679c\u4e0e\u8f6c\u5f55\u7ec4\u7279\u5f81\u4e4b\u95f4\u7684\u5173\u8054\u95ee\u9898\u3002\u6700\u8fd1\u7684\u6570\u636e\u8868\u660e\uff0c\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\uff08MIBC\uff09\u53ef\u4ee5\u6839\u636e\u57fa\u56e0\u8868\u8fbe\u5206\u4e3a\u56db\u79cd\u4e9a\u578b\uff0c\u5176\u4e2d\u6709\u4e24\u79cd\u8154\u5185\u4e9a\u578b\uff08\u8154\u51851\u548c\u8154\u51852\uff09\u548c\u4e24\u79cd\u57fa\u5e95\u4e9a\u578b<span style=\"color: rgb(203, 47, 21);\">&nbsp;(Fig 22.1)<\/span>\u3002\u63a2\u7d22\u6027\u5206\u6790\u663e\u793a\uff0c\u5728MIBC\u60a3\u8005\u4e2d\uff0c\u57fa\u5e95\u578b\uff0860%\uff09\u60a3\u8005\u7684\u514d\u75ab\u7ec6\u80dePD-L1\u8868\u8fbe\u9ad8\u4e8e\u8154\u5185\u578b\uff0823%\uff09\u60a3\u8005\u3002\u80bf\u7624\u7ec6\u80de\u4e0aPD-L1\u7684\u8868\u8fbe\u4ec5\u5728\u57fa\u5e95\u4e9a\u578b\u4e2d\u8f83\u9ad8\uff08\u57fa\u5e95\u4e9a\u578b39%\uff0c\u8154\u5185\u4e9a\u578b4%\uff09\u3002<\/p>\n<p style=\"white-space: normal;\">\u6b64\u5916\uff0cCD8+T\u6548\u5e94\u57fa\u56e0\u5728\u8154\u5185II\u578b\u548c\u57fa\u5e95\u4e9a\u578b\u4e2d\u90fd\u8868\u8fbe\u589e\u52a0\uff0c\u800c\u5728\u8154\u5185I\u578b\u4e2d\u8868\u8fbe\u4e0d\u660e\u663e\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e9b\u9ad8\u8868\u8fbeCD8+T\u6548\u5e94\u57fa\u56e0\u7684\u4e9a\u578b\u5728\u963f\u66ff\u5229\u73e0\u5355\u6297\u5e94\u7b54\u8005\u4e2d\u89c2\u5bdf\u5230\u8f83\u9ad8\u7684\u57fa\u7ebfIFN-\u0263\u5e94\u7b54\u57fa\u56e0\uff08\u8f83\u9ad8\u6c34\u5e73\u7684\u5e72\u6270\u7d20\u0263\uff0c\u7531CD8+T\u7ec6\u80de\u91ca\u653e\uff09\u3002\u8fd9\u4e9b\u6570\u636e\u4e0eTh1\u548cCTL\u514d\u75ab\u53cd\u5e94\u662f\u4e00\u81f4\u7684\u3002<\/p>\n<p style=\"white-space: normal;\">\u6240\u6709TCGA\u4e9a\u578b\u5bf9\u963f\u66ff\u5229\u73e0\u5355\u6297\u5747\u6709\u5e94\u7b54\uff0c\u4f46\u4e0e\u5176\u4ed6\u4e9a\u578b\u76f8\u6bd4\uff0c\u8154\u5185II\u578b\u4e9a\u578b\u7684MIBC\u5bf9\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u5e94\u7b54\u660e\u663e\u66f4\u9ad8\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660e\u8fd9\u4e9bMIBC\u4e9a\u578b\u5177\u6709\u4e0d\u540c\u7684\u80bf\u7624\u514d\u75ab\u7279\u6027\uff0c\u800c\u4e0d\u540c\u7684\u80bf\u7624\u514d\u75ab\u7279\u6027\u5c31\u5bfc\u81f4\u4e86\u4e0d\u540c\u4e9a\u578bMIBC\u5bf9\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u53cd\u5e94\u6027\u4e0d\u540c\uff1a<\/p>\n<ul class=\"list-paddingleft-1\" style=\"padding-left: 40px;list-style-position: outside;\">\n<li>\n<p style=\"white-space: normal;\">\u8154\u5185I\u578b\u80bf\u7624\u5177\u6709\u8f83\u4f4e\u7684\u6548\u5e94T\u7ec6\u80de\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\uff08\u201c\u514d\u75ab\u8352\u6f20\u201d\uff09<\/p>\n<\/li>\n<li>\n<p style=\"white-space: normal;\">\u8154\u5185II\u578b\u6709\u9ad8\u6548\u5e94T\u7ec6\u80de\u8868\u8fbe\u548c\u4f4e\u57fa\u8d28\u57fa\u56e0\u8868\u8fbe\uff08\u201c\u708e\u75c7\u80bf\u7624\u201d\uff09<\/p>\n<\/li>\n<li>\n<p style=\"white-space: normal;\">\u57fa\u5e95\u4e9a\u578b\u9ad8\u8868\u8fbe\u6548\u5e94T\u7ec6\u80de\u548c\u57fa\u8d28\u57fa\u56e0\uff08\u201c\u514d\u75ab\u6291\u5236\u201d\uff09<\/p>\n<\/li>\n<\/ul>\n<p style=\"white-space: normal;\">\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u8fd9\u4e9b\u521d\u6b65\u6570\u636e\u4e0eCheckMate 275\u7814\u7a76\u4e2d\u62a5\u9053\u7684PD-1\u6291\u5236\u5242\u7eb3\u6b66\u5355\u6297\u7684\u6570\u636e\u5e76\u4e0d\u5b8c\u5168\u4e00\u81f4\u3002\u8be5\u7814\u7a76\u663e\u793a\u80bf\u7624\u5fae\u73af\u5883\u4e2dIFN-\u0263\u7684\u542b\u91cf\u4e0e\u8f83\u9ad8\u7684\u5e94\u7b54\u7387\u548c\u8f83\u9ad8\u7684PD-L1\u8868\u8fbe\u76f8\u5173\u3002\u5728\u57fa\u8d28I\u4e9a\u578b\u7684MIBC\u60a3\u8005\u4e2dIFN-\u0263\u8868\u8fbe\u7684\u542b\u91cf\u662f\u6700\u9ad8\u7684\uff0c\u8be5\u4e9a\u578b\u60a3\u8005\u7684\u5e94\u7b54\u8005\u6bd4\u4f8b\u4e5f\u662f\u6700\u9ad8\uff0cCXCL9\u6216CXCL10\u8868\u8fbe\u6700\u9ad8\u3002\u8fd9\u4e9b\u6570\u636e\u9700\u8981\u5728\u7814\u7a76\u963f\u66ff\u5229\u73e0\u5355\u6297\u548c\u6d3e\u59c6\u5355\u6297\u7684\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u4e00\u6b65\u5f97\u5230\u8bc1\u5b9e\uff0c\u8fd9\u53ef\u80fd\u53cd\u6620\u4e86PD-1\/PD-L1\u6291\u5236\u5242\u4e4b\u95f4\u9776\u70b9\u5206\u5e03\u7684\u5dee\u5f02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.408812729498164\" data-s=\"300,640\"  data-type=\"png\" data-w=\"817\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-7513022ce2f41aa0ba611e66fd8144ca.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\" powered-by=\"xiumi.us\">\n<p><span style=\"color: rgb(203, 47, 21);\">Fig 22.1<\/span>&nbsp;\u8de8\u5c3f\u8def\u4e0a\u76ae\u764c\u4e9a\u578b\u7684\u514d\u75ab\u666f\u89c2<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">22.3.5 &nbsp;\u6211\u4eec\u8be5\u5982\u4f55\u589e\u52a0PD-1\/PD-L1\u514d\u75ab\u6291\u5236\u7597\u6cd5\u7684\u4e34\u5e8a\u7597\u6548\uff1f<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u7b2c\u4e8c\u4e2a\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u662f\u5982\u4f55\u589e\u52a0PD-1\u548cPD-L1\u6291\u5236\u5242\u7684\u53cd\u5e94\u60a3\u8005\u6bd4\u4f8b\u3002\u665a\u671f\u94c2\u57fa\u5316\u7597\u60a3\u8005\u4e2d\uff0c\u53ea\u670920%\u5bf9PD-1\u963b\u65ad\u5242\u6709\u53cd\u5e94\u3002\u4e0e\u5176\u4ed6\u80bf\u7624\uff08\u5982\u9ed1\u8272\u7d20\u7624\u6216\u80ba\u764c\uff09\u4e00\u6837\uff0c\u8054\u5408\u514d\u75ab\u7597\u6cd5\u5728\u8180\u80f1\u80bf\u7624\u4e2d\u53ef\u80fd\u6bd4\u5355\u4e00\u7597\u6cd5\u66f4\u6709\u6548\u3002\u8054\u5408\u514d\u75ab\u6cbb\u7597\u5df2\u88ab\u8bc1\u660e\u6bd4\u5355\u836f\u6cbb\u7597\u66f4\u80fd\u63d0\u9ad8\u4e34\u5e8a\u7597\u6548\u3002\u4f8b\u5982\uff0c\u5bf9\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u540c\u65f6\u7ed9\u4e88\u7eb3\u6b66\u5355\u6297\u548c\u4f0a\u5339\u5355\u6297\u6bd4\u5355\u836f\u6cbb\u7597\u4ea7\u751f\u66f4\u9ad8\u7684\u7f13\u89e3\u7387\u3002\u8054\u5408\u514d\u75ab\u53cd\u5e94\u80fd\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u6709\u6548\u3001\u66f4\u6301\u4e45\u7684\u7597\u6548\u3002<\/p>\n<p style=\"white-space: normal;\">\u8bc4\u4f30CTLA-4\u548cPD-1\u6291\u5236\u5242\u8054\u5408\u5e94\u7528\u7684\u57fa\u672c\u539f\u7406\u662f\uff0cCTLA-4\u548cPD-1\u7684\u673a\u5236\u662f\u76f8\u4e92\u72ec\u7acb\u7684\u3002\u8fd9\u8868\u660e\u9776\u5411\u4e24\u8005\u90fd\u53ef\u80fd\u5177\u6709\u6dfb\u52a0\u6216\u534f\u540c\u6d3b\u6027\uff0c\u65e0\u8bbaPD-L1\u9633\u6027\u6216PD-L1\u9634\u6027\u4eba\u7fa4\u3002\u6b64\u5916\uff0cCTLA-4\u6291\u5236\u5242\u5df2\u88ab\u8bc1\u660e\u53ef\u4e0a\u8c03PD-1\uff0c\u800cPD-1\u4e5f\u5df2\u88ab\u8bc1\u660e\u53ef\u4e0a\u8c03CTLA-4\u3002\u8fd9\u4e3a\u8054\u5408\u4f7f\u7528\u66ff\u897f\u6728\u5355\u6297\u548c\u5fb7\u74e6\u9c81\u5355\u6297\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u73b0\u5b9e\u4f9d\u636e\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u8868\u660e\uff0cPD-L1\u9634\u6027\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u63a5\u53d7PD-1\u6291\u5236\u5242\uff08\u7eb3\u6b66\u5355\u6297\u6216\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff09+ CTLA-4\u6291\u5236\u5242\uff08\u4f0a\u5339\u5355\u6297\u6216\u66f2\u7f8e\u6728\u5355\u6297\uff09\u8054\u5408\u6cbb\u7597\u6bd4\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u5355\u836f\u6cbb\u7597\u7684\u7f13\u89e3\u7387\uff08\u5206\u522b\u4e3a30\u548c70%\uff09\u548c\u75be\u75c5\u63a7\u5236\u7387\uff08\u5206\u522b\u4e3a10\u548c42%\uff09\u66f4\u9ad8\u3002\u8fd9\u79cd\u65b9\u6cd5\u76ee\u524d\u6b63\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e2d\u8fdb\u884c1\/2\u671f\u8bd5\u9a8c\u3002<\/p>\n<p style=\"white-space: normal;\">\u6b64\u5916\uff0c\u6b63\u5728\u8fdb\u884c\u76841\u671f\u8bd5\u9a8c\u7814\u7a76\u4e86\u4ee5PD-1\u6291\u5236\u5242\u6216PD-L1\u6291\u5236\u5242\u4e3a\u9aa8\u67b6\u7684\u5176\u4ed6\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08\u5982LAG-3\u3001VISTA\uff09\u6216\u6fc0\u6d3b\u5242\u514d\u75ab\u68c0\u67e5\u70b9\uff08\u5982OX40\u3001CD27\uff09\u7684\u7ec4\u5408\u3002\u53e6\u4e00\u79cd\u7b56\u7565\u662f\u5c06\u5316\u7597\u6216\u653e\u7597\u7b49DNA\u635f\u4f24\u5242\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u76f8\u7ed3\u5408\u3002\u7406\u7531\u662f\u5e38\u89c4\u836f\u7269\u53ef\u80fd\u4f1a\u589e\u52a0\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u7a81\u53d8\u8d1f\u8377\uff0c\u4ece\u800c\u5bfc\u81f4\u60a3\u8005\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6709\u66f4\u9ad8\u7684\u54cd\u5e94\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row nowrap;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 2;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><strong>22.4&nbsp;&nbsp;&nbsp;&nbsp; \u5c55\u671b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u65e9\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u8bc1\u660e\uff0c\u5728\u7ecf\u8fc7\u5316\u7597\u6cbb\u7597\u7684\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e2d\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5177\u6709\u663e\u8457\u7684\u75be\u75c5\u7f13\u89e3\u7387\u3001\u6301\u4e45\u7684\u7597\u6548\u4ee5\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6700\u8fd1\u7684\u4e09\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0cPD-1\u6291\u5236\u5242\u53ef\u4ee5\u6539\u5584\u81f4\u6b7b\u6027\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u7684\u9884\u540e\u3002\u8003\u8651\u5230\u8fd9\u4e9b\u7814\u7a76\u6570\u636e\uff0c\u672a\u6765\u51e0\u4e2a\u6708\u5185\u5c06\u4f1a\u8fdb\u884cPD-1\/PD-L1\u963b\u65ad\u5242\u5728\u6ca1\u6709\u7ecf\u8fc7\u5316\u7597\u6cbb\u7597\u7684\u8f6c\u79fb\u6027MIBC\u3001\u975e\u8f6c\u79fb\u6027MIBC\uff0c\u751a\u81f3\u5728\u5361\u4ecb\u82d7\u6cbb\u7597\u65e0\u53cd\u5e94\u7684\u9ad8\u7ea7\u522b\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\uff08NMIBC\uff09\u7684\u75be\u75c5\u65e9\u671f\u7684\u6f5c\u5728\u5e94\u7528\u7814\u7a76<span style=\"color: rgb(203, 47, 21);\">(Table 22.3)<\/span>\u3002<\/p>\n<p style=\"white-space: normal;\">\u56e0\u6b64\uff0cPD-1\u548cPD-L1\u6291\u5236\u5242\u5c06\u6210\u4e3a\u672a\u6765\u57fa\u7840\u514d\u75ab\u6cbb\u7597\u7684\u9aa8\u5e72\uff0c\u7279\u522b\u662f\u5728\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e2d\u3002\u672a\u6765PD-1\u548cPD-L1\u6291\u5236\u5242\u7684\u53d1\u5c55\u9700\u8981\u4e0e\u5176\u4ed6\u514d\u75ab\u6291\u5236\u5242\u5408\u7406\u5730\u7ec4\u5408\u4f7f\u7528\u3002<\/p>\n<p style=\"white-space: normal;\">\u7136\u800c\uff0c\u65b0\u7684\u95ee\u9898\u662f\u5982\u4f55\u63d0\u9ad8\u53ef\u80fd\u53d7\u76ca\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u60a3\u8005\u6570\u91cf\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u591a\u671f1\u671f\u8bd5\u9a8c\uff0c\u8bc4\u4f30\u5404\u79cd\u8054\u5408\u6cbb\u7597\u7ec4\u5408\u3002\u7406\u60f3\u60c5\u51b5\u4e0b\uff0c\u8fd9\u4e9b\u836f\u7269\u7ec4\u5408\u5e94\u8be5\u57fa\u4e8e\u6f5c\u5728\u7684\u80bf\u7624\u6297\u836f\u673a\u5236\u3002\u8154\u5185I\u578b\u80bf\u7624\u7684\u7279\u70b9\u662f\u201c\u514d\u75ab\u8352\u6f20\u201d\u548cFGFR2\u548cFGFR3\u57fa\u56e0\u7578\u53d8\u3002\u8fd9\u8868\u660e\uff0c\u901a\u8fc7\u5316\u7597\u3001\u653e\u7597\u6216FGFR\u6291\u5236\u5242\u53ef\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\uff0c\u6b7b\u4ea1\u7684\u80bf\u7624\u7ec6\u80de\u91ca\u653e\u80bf\u7624\u6297\u539f\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u5bfc\u81f4\u5bf9\u968f\u540e\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6548\u679c\u66f4\u52a0\u654f\u611f\u3002<\/p>\n<p style=\"white-space: normal;\">\u53e6\u4e00\u79cd\u65b9\u6cd5\u662f\u5728\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e4b\u524d\uff0c\u4f7f\u7528\u643a\u5e26\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u7684\u75ab\u82d7\u6765\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u4ece\u800c\u63d0\u9ad8\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u53cd\u5e94\u7387\u3002\u5bf9\u4e8e\u4ee5\u9ad3\u7cfb\u7ec6\u80de\u9ad8\u6d78\u6da6\u4e3a\u7279\u5f81\u7684\u57fa\u5e95\u80bf\u7624\uff0c\u8054\u5408\u7528\u836f\u5e94\u9488\u5bf9\u6291\u5236\u514d\u75ab\u73af\u5883\u3002\u5432\u54da\u80fa2,3-\u53cc\u52a0\u6c27\u9176(Indoleamine 2,3-dioxygenase, IDO)\u548c\u7ec6\u80de\u5185\u9ad8\u6d53\u5ea6\u7684\u817a\u82f7\u5728\u8bf1\u5bfc\u6291\u5236\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u529f\u80fd\u7684\u9014\u5f84\u4e2d\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff0c\u56e0\u6b64\u9776\u5411IDO1\u548c\u817a\u82f7A2a\u53d7\u4f53(A2aR)\u4e5f\u662f\u5c3f\u8def\u4e0a\u76ae\u764c\u6cbb\u7597\u7684\u4e00\u4e2a\u5f88\u6709\u5e0c\u671b\u7684\u9776\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"2.204044117647059\" data-s=\"300,640\"  data-type=\"png\" data-w=\"544\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-1420103ff022cf8868c78140b20c477d.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\" powered-by=\"xiumi.us\">\n<p><span style=\"color: rgb(203, 47, 21);\">Table 22.3<\/span>&nbsp;UC\u7684\u4e3b\u89813\u671f\u8bd5\u9a8c\u3002DFS, \u65e0\u75c5\u751f\u5b58\u671f\uff1bMIBC, \u808c\u8089\u6d78\u6da6\u6027\u8180\u80f1\u764c\uff1bmUC, \u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\uff1bOS, \u603b\u751f\u5b58\u671f\uff1bPFS, \u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u672a\u6765\u7684\u7814\u7a76\u5de5\u4f5c\u5e94\u8be5\u96c6\u4e2d\u5728\u201c\u660e\u786e\u53ef\u4ee5\u9884\u6d4b\u60a3\u8005\u5bf9\u514d\u75ab\u6291\u5236\u5242\u662f\u5426\u6709\u53cd\u5e94\u7684\u9884\u6d4b\u6027\u751f\u7269\u6807\u5fd7\u7269\u201d\u4e0a\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u8bc6\u522b\u521b\u65b0\u7684\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u5c06\u6709\u671b\u5e2e\u52a9\u533b\u751f\u5728\u60a3\u8005\u4e2a\u4f53\u5c42\u9762\u4e0a\u9884\u6d4b\u60a3\u8005\u662f\u5426\u53ef\u4ee5\u4ece\u7279\u5b9a\u7684\u514d\u75ab\u6cbb\u7597\u6216\u8054\u5408\u514d\u75ab\u6cbb\u7597\u4e2d\u53d7\u76ca\u3002\u8fd9\u4e9b\u751f\u7269\u6807\u5fd7\u7269\u53ef\u4ee5\u901a\u8fc7\u7279\u5b9a\u7684\u80bf\u7624\u6216\u5bbf\u4e3b\u6807\u8bb0\u7269\uff08\u4f8b\u5982\uff0c\u8840\u6e05\u3001\u5fae\u751f\u7269\u7fa4\u7b49\uff09\u6216\u4e24\u8005\u5171\u540c\u51b3\u5b9a\uff0c\u4ee5\u7efc\u5408\u8003\u8651\u80bf\u7624\u548c\u514d\u75ab\u7cfb\u7edf\u9ad8\u5ea6\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u51b3\u5b9a\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u8bf1\u5bfc\u673a\u4f53\u4ea7\u751f\u66f4\u6709\u6548\u7684\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);text-align: start;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);font-size: 16px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;text-align: center;visibility: visible;\">\n<p style=\"margin-bottom: 10px;outline: 0px;\"><span style=\"outline: 0px;color: rgb(0, 0, 0);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 12px;letter-spacing: 0.544px;\">\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><br style=\"outline: 0px;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;background-color: rgb(255, 255, 255);text-align: center;\"><br style=\"outline: 0px;letter-spacing: 0.544px;\"  \/><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);\"><span style=\"outline: 0px;color: rgb(0, 0, 0);font-size: 12px;\">\u2014&nbsp;THE&nbsp;&nbsp;END&nbsp;\u2014<\/span><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u6765\u6e90&nbsp;|&nbsp;Oncoimmunology:&nbsp;A&nbsp;Practical&nbsp;Guide&nbsp;<\/span><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">for&nbsp;Cancer&nbsp;Immunotherapy<\/span><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u4f5c\u8005&nbsp;|&nbsp;<\/span><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\">Pernelle Lavaud and Yohann Loriot<\/span><\/span><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;letter-spacing: 0.54px;\">\u521d\u7a3f\u7ffb\u8bd1&nbsp;|&nbsp;<span style=\"outline: 0px;letter-spacing: 0.54px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\"><span style=\"outline: 0px;letter-spacing: 0.54px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\">\u9648\u6653\u610f \u90ed\u5b50&nbsp;\u7f57\u4f73\u4f73<\/span><\/span><\/span><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><span data-raw-text=\"\u7f16\" data-textnode-index=\"127\" data-index=\"7100\" style=\"outline: 0px;\">\u7f16\u8f91\u6392\u7248<\/span><span style=\"outline: 0px;letter-spacing: 0.54px;\">&nbsp;| \u5e94\u6b63<span style=\"outline: 0px;letter-spacing: 0.54px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\"><span style=\"outline: 0px;letter-spacing: 0.54px;caret-color: rgba(0, 0, 0, 0);\"><span style=\"outline: 0px;letter-spacing: 0.54px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\"><\/span><\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u5ba1\u6838\u4fee\u6539&nbsp;|&nbsp;\u738b\u5764&nbsp;\u80e1\u73ca<\/span><\/p>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><strong style=\"outline: 0px;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n<p style=\"outline: 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style=\"outline: 0px;visibility: visible;\">\n<section style=\"margin-top: 24px;outline: 0px;visibility: visible;\"><strong style=\"outline: 0px;text-indent: 0em;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;letter-spacing: 0.54px;text-align: center;visibility: visible;\"><strong style=\"outline: 0px;color: rgb(64, 118, 0);font-family: Arial, sans-serif;letter-spacing: 2px;visibility: visible;\"><\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"margin-bottom: 0em;outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;line-height: 2em;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;visibility: visible;\">\n<section style=\"padding: 29px;outline: 0px;display: inline-block;width: 677px;vertical-align: top;background-color: rgba(97, 155, 139, 0.09);align-self: flex-start;flex: 0 0 auto;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: justify;visibility: visible;\">\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2826543872209125379&amp;count=3#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;color: var(--weui-LINK);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;cursor: pointer;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=MzAwMDUzNTIxNA==&amp;action=getalbum&amp;album_id=1647467076418060289#wechat_redirect\" textvalue=\"\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;letter-spacing: 0.544px;\" rel=\"noopener\">\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2018077716062715908&amp;count=3#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2822922341205737475&amp;count=3#wechat_redirect\" textvalue=\"ACIR\u6587\u732e\u901f\u9012\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564295698236358662&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u4f5c\u56fe\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564293167342993409&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1894714083283615746&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456254175&amp;idx=1&amp;sn=d302a786f8fea3868ee719195418af61&amp;scene=21#wechat_redirect\" textvalue=\"R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564291300860936193&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;color: var(--weui-LINK);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;cursor: pointer;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564278007870046209&amp;count=3#wechat_redirect\" textvalue=\"RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;letter-spacing: 0.544px;\" rel=\"noopener\">RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564286064490496000&amp;count=3#wechat_redirect\" textvalue=\"\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\" rel=\"noopener\">\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"162\" data-cropsely1=\"0\" data-cropsely2=\"162\" data-fileid=\"308764751\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"jpeg\" data-w=\"258\" style=\"outline: 0px;color: rgb(0, 0, 0);font-size: 14px;letter-spacing: 0.54px;display: initial;visibility: visible !important;width: 162px !important;\" width=\"162px\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-37436bfb03f3af56c2d9d1f15d025bb9.jpeg\"><\/span><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u5173\u6ce8\u672c\u53f7~<\/span><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"155\" data-cropsely1=\"0\" data-cropsely2=\"155\" data-fileid=\"308764752\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"613\" width=\"147px\"  style=\"outline: 0px;display: initial;visibility: visible !important;width: 147px !important;\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-31c5899f9f8bf52a8d71c2727d9fa17d.jpeg\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n<p style=\"outline: 0px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"margin-bottom: 0em;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"147\" data-cropsely1=\"0\" data-cropsely2=\"147\" data-fileid=\"308764752\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"png\" data-w=\"400\" style=\"outline: 0px;display: initial;visibility: visible !important;width: 172px !important;\" width=\"172px\" src=\"http:\/\/dh.oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-19b3b83ce1f57adda5547d3f49a89758.png\"><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;text-align: right;line-height: 1.6em;\"><span style=\"outline: 0px;font-size: 15px;background-color: rgb(249, 237, 166);\">\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;text-align: right;line-height: 1.6em;\"><span style=\"outline: 0px;font-size: 15px;background-color: rgb(249, 237, 166);\">\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<blockquote>\n<p>\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c22\u7ae0\uff1a\u5361\u4ecb\u82d7\u548c\u6297PD-L1\u6297\u4f53\u5728\u8180\u80f1\u80bf\u7624\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09 22.3.3&nbsp;&nbsp; PD-1 \u548c PD-L1 \u6291\u5236\u5242\u4f1a\u6539\u53d8\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u80bf\u7624\u7684\u62a4\u7406\u6807\u51c6 \u7814&hellip;<\/p>\n","protected":false},"author":1,"featured_media":5205,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5209"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5209"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5209\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5205"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5209"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}