{"id":5218,"date":"2023-08-03T11:51:11","date_gmt":"2023-08-03T03:51:11","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/03\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac23%e7%ab%a0%ef%bc%9a-pd-l1%e5%92%8c%e5%85%b6%e4%bb%96%e5%85%8d%e7%96%ab%e5%ad%a6%e8%af%8a%e6%96%ad%e5%b7%a5%e5%85%b7%ef%bc%88%e4%b8%8b%ef%bc%89\/"},"modified":"2023-08-03T11:51:11","modified_gmt":"2023-08-03T03:51:11","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac23%e7%ab%a0%ef%bc%9a-pd-l1%e5%92%8c%e5%85%b6%e4%bb%96%e5%85%8d%e7%96%ab%e5%ad%a6%e8%af%8a%e6%96%ad%e5%b7%a5%e5%85%b7%ef%bc%88%e4%b8%8b%ef%bc%89","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/03\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac23%e7%ab%a0%ef%bc%9a-pd-l1%e5%92%8c%e5%85%b6%e4%bb%96%e5%85%8d%e7%96%ab%e5%ad%a6%e8%af%8a%e6%96%ad%e5%b7%a5%e5%85%b7%ef%bc%88%e4%b8%8b%ef%bc%89\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c23\u7ae0\uff1a PD-L1\u548c\u5176\u4ed6\u514d\u75ab\u5b66\u8bca\u65ad\u5de5\u5177\uff08\u4e0b\uff09"},"content":{"rendered":"
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23.4 PD-L1\u7684\u8868\u8fbe\u5728\u80bf\u7624\u5fae\u73af\u5883(TME)\u4e2d\u6709\u4f55\u610f\u4e49\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1\/PD-L\u8f74\u7531\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d1(PD-1)\u53ca\u5176\u914d\u4f53(PDL1\u548cPD-L2)\u7ec4\u6210\uff0c\u662f\u7ef4\u6301\u5916\u5468\u8010\u53d7\u7684\u91cd\u8981\u751f\u7406\u673a\u5236\u4e4b\u4e00\u3002\u5b83\u662f\u63a7\u5236\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u53cd\u5e94\u5f3a\u5f31\u7684\u5173\u952e\uff0c\u4e0e\u8bb8\u591a\u5176\u4ed6\u6291\u5236\u6027\u53d7\u4f53\u9014\u5f84\u4e0d\u540c\uff0c\u5176\u5728\u51e0\u4e4e\u6240\u6709\u7c7b\u578b\u7684\u708e\u75c7\u6761\u4ef6\u4e0b\u90fd\u6709\u4f5c\u7528\u3002PD-1\u5728\u6d3b\u5316\u7684T\u7ec6\u80de\u548cB\u7ec6\u80de\u4e0a\u8868\u8fbe\u3002PD-1\u8868\u8fbe\u7684\u6c34\u5e73\u548c\u65f6\u95f4\u7a97\u53e3\u4e0e\u7ec6\u80de\u672c\u8eab\u7279\u6027\u548c\u6301\u7eed\u523a\u6fc0\u76f8\u5173\uff0cT\u7ec6\u80de\u7684PD-1\u8868\u8fbe\u662f\u7531TCR\u4f9d\u8d56\u7684\u6fc0\u6d3b\u4fe1\u53f7\u8bf1\u5bfc\u7684\u3002PD-L1\u548cPD-L2\u901a\u5e38\u7531\u5de8\u566c\u7ec6\u80de\u4e9a\u7fa4\u8868\u8fbe\uff0c\u4f46\u53ef\u5728\u591a\u79cd\u9020\u8840\u7ec6\u80de\u548c\u975e\u9020\u8840\u7ec6\u80de\u4e2d\u88ab\u591a\u79cd\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u3002PD-1\/PD-L1\u53c2\u4e0e\u6291\u5236T\u7ec6\u80de\u7684\u6838\u5fc3\u529f\u80fd\uff0c\u5305\u62ec\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3001\u589e\u6b96\u548c\u7ec6\u80de\u6bd2\u6027\u9897\u7c92\u7684\u5f62\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80bf\u7624\u53ef\u80fd\u5229\u7528PD-1\/PD-L1\u8f74\u6765\u9003\u907fT\u7ec6\u80de\u4ecb\u5bfc\u7684\u653b\u51fb\u3002\u5728TME\u4e2d\uff0cPD-L1\u53ef\u5728\u9ed1\u8272\u7d20\u7624\u4e2d\u8868\u8fbe\u56db\u79cd\u4e0d\u540c\u7ec4\u7ec7\u5b66\u6a21\u5f0f\uff0c\u5305\u62ec\uff1a(1)PD-L1(+)\/TIL+, (2) PD-L1(+)\/TIL-, (3)PD-L1(\u2212)\u548cTIL+, (4)PD-L1(\u2212)\/TIL-\uff0cFig. 23.3A<\/span>\u3002 \u81ea\u4ece\u6700\u521d\u7684\u8fd9\u4e00\u63cf\u8ff0\u51fa\u73b0\u4ee5\u6765\uff0c\u8fd9\u4e9b\u6a21\u5f0f\u5df2\u7ecf\u5728\u5f88\u591a\u5b9e\u4f53\u80bf\u7624\u7c7b\u578b\u4e2d\u88ab\u5e94\u7528\uff0c\u5982\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u809b\u95e8\u9cde\u72b6\u7ec6\u80de\u764c(SCC)\u548c\u4e73\u817a\u764c\u3002\u6bcf\u4e00\u79cd\u6a21\u5f0f\u90fd\u4ee3\u8868\u4e86\u4e0d\u540c\u7684\u514d\u75ab\u5fae\u73af\u5883\uff0cFig. 23.3<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 23.3<\/span> PD-L1\u8868\u8fbe\u6a21\u5f0f\u548cTIL(\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de)\u5b9a\u4e49\u4e86\u4e0d\u540c\u7684\u80bf\u7624\u5fae\u73af\u5883\u3002\u5728\u8868\u73b0\u51faPD-L1\u8868\u8fbe\u7684\u9002\u5e94\u6027\u514d\u75ab\u62b5\u6297\u6a21\u5f0f\u7684\u80bf\u7624\u4e2d(\u5de6\u4e0a<\/strong>)\uff0c\u6fc0\u6d3b\u7684\u3001\u5728\u5bbf\u4e3b-\u80bf\u7624\u754c\u9762\u8868\u8fbePD-1\u7684T\u7ec6\u80de\u5206\u6ccc\u5e72\u6270\u7d20-\u0263\u548c\u5176\u4ed6\u708e\u6027\u7ec6\u80de\u56e0\u5b50\uff0c\u8fd9\u53cd\u8fc7\u6765\u53c8\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u548c\u76f8\u5173\u514d\u75ab\u7ec6\u80de\u8868\u8fbePD-L1\u3002PD-L1\u968f\u540e\u4e0eT\u7ec6\u80de\u7ed3\u5408\uff0c\u5bfc\u81f4T\u7ec6\u80de\u6291\u5236\uff0c\u4fc3\u8fdb\u514d\u75ab\u8010\u53d7\u3002\u5bf9\u4e8e\u8868\u73b0\u51fa\u5148\u5929PD-L1\u8868\u8fbe\u6a21\u5f0f\u7684\u80bf\u7624(\u5de6\u4e0b<\/strong>)\uff0c\u7a81\u53d8(\u4f8b\u5982\uff0cPTEN)\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u7684\u7ed3\u6784\u6027PD-L1\u8868\u8fbe\uff0c\u8fd9\u79cd\u8868\u8fbe\u72ec\u7acb\u4e8eTIL\u3002PD-L1(\u2212)\/TIL+\u80bf\u7624\u662f\u90a3\u4e9b\u514d\u75ab\u65e0\u6548\u7684\u80bf\u7624(\u53f3\u4e0a<\/strong>)\uff0c\u5bfc\u81f4\u8fd9\u79cd\u8868\u578b\u7684\u56e0\u7d20\u5305\u62ec\u90a3\u4e9b\u6270\u4e71\u9002\u5e94\u6027\u514d\u75ab\u62b5\u6297\u9014\u5f84\u7684\u56e0\u7d20\uff0c\u5305\u62ecTIL\u7684\u6fc0\u6d3b\u6216\u529f\u80fd\u7f3a\u9677\uff0c\u6216\u8005\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u5bf9\u5e72\u6270\u7d20-\u0263\u7684\u529f\u80fd\u969c\u788d\u7684\u7a81\u53d8\u3002PD-L1(\u2212)\/TIL\u2212\u80bf\u7624\u88ab\u514d\u75ab\u5ffd\u89c6(\u53f3\u4e0b<\/strong>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD-L1(+)\/TIL-\u548c PD-L1(+)\/TIL+\u4e24\u79cd\u6a21\u5f0f\u88ab\u8ba4\u4e3a\u5206\u522b\u4e0e\u80bf\u7624\u7684\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u6297\u6027\u76f8\u5173\u3002\u5148\u5929\u514d\u75ab\u62b5\u6297\u662f\u6307\u539f\u764c\u57fa\u56e0\u9a71\u52a8\u7684PD-L1\u7684\u7ed3\u6784\u6027\u8868\u8fbe\u3002\u7ec4\u7ec7\u5b66\u4e0a\uff0c\u8fd9\u8868\u73b0\u4e3a\u80bf\u7624\u7ec6\u80de\u8868\u9762\u5e7f\u6cdb\u8868\u8fbePD-L1\uff0c\u5b83\u7684\u8868\u8fbe\u4f4d\u7f6e\u4e0eTIL\u7684\u5b58\u5728\u4f4d\u7f6e\u65e0\u5173\u3002\u4e0ePD-L1\u8868\u8fbe\u589e\u52a0\u76f8\u5173\u7684\u9057\u4f20\u5f02\u5e38\u5305\u62ecPTEN\u7f3a\u5931\u3001PI3K-AKT\u7a81\u53d8\u548c\u4e5d\u53f7\u67d3\u8272\u4f53\u6269\u589e\u3002<\/p>\n

PD-L1\u8868\u8fbe\u7684\u9002\u5e94\u6027\u514d\u75ab\u62b5\u6297\u6a21\u5f0f\u5728\u7ec4\u7ec7\u5b66\u4e0a\u7684\u7279\u5f81\u662fPD-L1\u663e\u793a\u5728\u7d27\u90bbTIL\u7684\u80bf\u7624\u7ec6\u80de\u6216\u514d\u75ab\u7ec6\u80de\u4e0a\u3002\u8fd9\u79cd\u6a21\u5f0f\u6700\u5e38\u89c1\u4e8e\u80bf\u7624\u7684\u6d78\u6da6\u6027\u8fb9\u7f18(TIL\u901a\u5e38\u5bc6\u5ea6\u6700\u9ad8)\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0cPD-L1\u7684\u8868\u8fbe\u662f\u7531\u5e72\u6270\u7d20-\u03b3\u548c\u5176\u4ed6\u7531\u6fc0\u6d3b\u7684\u514d\u75ab\u7ec6\u80de\u5206\u6ccc\u7684\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u7684\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u80bf\u7624\u7ec6\u80de\u4e5f\u53ef\u80fd\u8868\u73b0\u51fa\u8fd9\u4e24\u79cd\u673a\u5236\u7684\u6df7\u5408\uff0c\u5373\u5728\u7ed3\u6784\u6027PD-L1\u8868\u8fbe\u7684\u57fa\u7840\u4e0a\u53e0\u52a0\u4e86\u9002\u5e94\u6027PD-L1\u7684\u6210\u5206\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53ef\u80fd\u662fPD-L1\u8868\u8fbe\u7684\u4e0d\u540c\u751f\u7269\u5b66\u673a\u5236\u5bfc\u81f4\u4e86\u6587\u732e\u4e2d\u5173\u4e8ePD-L1\u8868\u8fbe\u5bf9\u9884\u540e\u7684\u5f71\u54cd\u7684\u76f8\u4e92\u77db\u76fe\u7684\u62a5\u9053\u3002\u5f53\u7814\u7a76PD-L1\u8868\u8fbe\u7684\u9002\u5e94\u6027\u6a21\u5f0f\u65f6\uff0c\u5b83\u5728\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e73\u817a\u764c\u548c\u5589\u764c\u7b49\u80bf\u7624\u7c7b\u578b\u4e2d\u662f\u4e00\u4e2a\u79ef\u6781\u9884\u540e\u7279\u5f81\u3002\u8fd9\u4e0e\u9002\u5e94\u6027PD-L1\u8868\u8fbe\u4ee3\u8868\u673a\u4f53\u5bf9\u80bf\u7624\u7684\u6301\u7eed\u514d\u75ab\u53cd\u5e94\u7684\u89c2\u70b9\u662f\u4e00\u81f4\u7684\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u9ed1\u8272\u7d20\u7624\u4e2dPD-L1\u7684\u7ed3\u6784\u6027\u8868\u8fbe\u4e0e\u8f83\u5dee\u7684\u9884\u540e\u76f8\u5173\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86\u7406\u89e3PD-L1\u8868\u8fbe\u7684\u4f4d\u7f6e\u73af\u5883\u7684\u5fc5\u8981\u6027\uff0c\u800c\u4e0d\u662f\u6ce8\u610f\u5b83\u662f\u5426\u7b80\u5355\u5730\u5b58\u5728\u4e8eTME\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TIL-\u548cTIL+\u7684\u4e24\u79cdPD-L1(\u2212)\u6a21\u5f0f\u4e5f\u4ee3\u8868\u4e86\u4e0d\u540c\u7684\u6f5c\u5728\u751f\u7269\u5b66\u7279\u5f81\u3002\u8fd9\u5bfc\u81f4PD-L1(\u2212)\/TIL+\u578b\u5fae\u73af\u5883\u7684\u673a\u5236\u66f4\u52a0\u5f02\u8d28\u5316\uff0c\u73b0\u4ecd\u5728\u7814\u7a76\u4e2d\u3002\u53ef\u80fd\u7684\u89e3\u91ca\u5305\u62ecTIL\u7684\u4e0d\u540c\u529f\u80fd\u72b6\u6001\uff0c\u5373TIL\u4e0d\u5206\u6ccc\u5e72\u6270\u7d20-\u03b3\uff0c\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\u5185\u5e72\u6270\u7d20-\u03b3\u53d7\u4f53\u7ea7\u8054\u7684\u53d8\u5316\u3002\u4e5f\u6709\u53ef\u80fd\u80bf\u7624\u901a\u8fc7\u53e6\u4e00\u79cd\u673a\u5236\u9003\u907f\u514d\u75ab\u7cfb\u7edf\uff0c\u5305\u62ec\u6f5c\u5728\u7684\u9664PD-1\/PD-L1\u4ee5\u5916\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u3002\u53e6\u4e00\u65b9\u9762\uff0cPD-L1(\u2212)\/TIL\u2212\u60a3\u8005\u7684\u80bf\u7624\u57fa\u672c\u4e0a\u88ab\u514d\u75ab\u7cfb\u7edf\u5ffd\u89c6\u4e86\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e9bPD-L1\u8868\u8fbe\u6a21\u5f0f\u4e2d\u7684\u6bcf\u4e00\u79cd\u4e5f\u53ef\u80fd\u5177\u6709\u6cbb\u7597\u610f\u4e49\u3002\u4f8b\u5982\uff0c\u5177\u6709\u9002\u5e94\u6027\u514d\u75ab\u6297\u6027\u6a21\u5f0f\uff08PD-L1+\/TIL+\uff09\u7684\u60a3\u8005\u88ab\u8ba4\u4e3a\u662f\u5bf9\u6297PD-1\/PD-L1\u5355\u4e00\u7597\u6cd5\u6700\u6709\u53ef\u80fd\u7684\u53cd\u5e94\u3002\u60a3\u6709\u514d\u75ab\u5ffd\u89c6\u80bf\u7624\uff08PD-L1- \/TIL-\uff09\u6216\u8868\u73b0\u51fa\u7eaf\u7cb9\u7684\u5148\u5929\u514d\u75ab\u62b5\u6297\u6a21\u5f0f\uff08PD-L1+\/TIL-\uff09\u7684\u4e2a\u4f53\u53ef\u80fd\u9700\u8981\u63a5\u79cd\u75ab\u82d7\u6216\u5176\u4ed6\u6cbb\u7597\uff0c\u5728PD-1\/PD-L1\u68c0\u67e5\u70b9\u963b\u65ad\u4e4b\u5916\u4fc3\u8fdb\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u3002\u8868\u73b0\u4e3a\u9002\u5e94\u6027\u548c\u7ec4\u6210\u578b\u76f8\u7ed3\u5408\u7684\u80bf\u7624\u5bf9\u6297PD-1\/PD-L1\u7684\u654f\u611f\u6027\u4ecd\u4e0d\u6e05\u695a\uff0c\u4f46\u5f88\u53ef\u80fd\u4e0e\u7279\u5b9aTIL\u4e9a\u7fa4\u7684\u5bc6\u5ea6\u548c\u5206\u5e03\u6709\u5173\u3002\u6700\u540e\uff0cPD-L1 – \/TIL+\u80bf\u7624\u7684\u65b9\u6cd5\u5c06\u53d6\u51b3\u4e8e\u80bf\u7624\u548cTIL\u7684\u5176\u4ed6\u7279\u5f81\u3002\u4f8b\u5982\uff0c\u643a\u5e26JAK1\u6216JAK2\u7a81\u53d8\u7684\u80bf\u7624\u53ef\u5e72\u6270\u80bf\u7624\u7ec6\u80de\u54cd\u5e94IFN-\u03b3\u800c\u4e0a\u8c03PD-L1\u7684\u80fd\u529b\uff0c\u4ece\u800c\u53ef\u4ee5\u5bf9PD-1\u963b\u65ad\u4ea7\u751f\u6297\u6027\u3002\u80bf\u7624\u901a\u8fc7\u5176\u4ed6\u7684\u68c0\u67e5\u70b9\u5206\u5b50\u6216\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u4ee5\u5916\u7684TIL\u4e9a\u7fa4\u8eb2\u907f\u514d\u75ab\u7cfb\u7edf\uff0c\u4e5f\u53ef\u80fd\u663e\u793a\u51fa\u7c7b\u4f3c\u7684\u6a21\u5f0f\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u80bf\u7624\u53ef\u80fd\u9700\u8981\u963b\u65ad\u53e6\u4e00\u4e2a\u68c0\u67e5\u70b9\uff0c\u8054\u5408\u514d\u75ab\u7597\u6cd5\uff0c\u6216\u8005\u5bf9\u4e8e\u771f\u6b63\u7684IFN-\u03b3\u8010\u836f\u7684\u80bf\u7624\uff0c\u9700\u8981\u514d\u75ab\u7597\u6cd5\u4ee5\u5916\u7684\u53e6\u4e00\u79cd\u5f62\u5f0f\u7684\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

23.5 \u5176\u4ed6\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

23.5.1 \u7a81\u53d8\u8d1f\u8377<\/p>\n<\/section>\n

\n
\n
\n

\u80bf\u7624\u7ec6\u80de\u7684\u7279\u5f81\u4e4b\u4e00\u662f\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4e00\u4e2a\u80bf\u7624\u7ec6\u80de\u5e73\u5747\u8868\u73b0\u51fa\u5927\u7ea6120\u4e2a\u975e\u540c\u4e49\u7a81\u53d8\uff0c\u8fd9\u4e2a\u6570\u5b57\u53ef\u4ee5\u589e\u52a0\u5230\u5927\u7ea62000\u4e2a\u3002\u8f83\u9ad8\u7684\u7a81\u53d8\u8d1f\u8377\u4e0e\u67d0\u4e9b\u764c\u75c7\u7684\u9884\u540e\u6539\u5584\u6709\u5173\u3002\u8fd9\u88ab\u8ba4\u4e3a\u662f\u56e0\u4e3a\u8fd9\u4e9b\u7a81\u53d8\u53ef\u4ea7\u751f\u514d\u75ab\u539f\u6027\u65b0\u6297\u539f\u3002\u5f53\u786e\u5b9a\u4e86\u4e00\u7cfb\u5217\u764c\u75c7\u7c7b\u578b\u7684\u7a81\u53d8\u60c5\u51b5\u540e\uff0c\u8bb8\u591a\u7a81\u53d8\u8d1f\u8377\u6700\u9ad8\u7684\u764c\u75c7(\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u8180\u80f1\u764c)\u5728\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5bf9PD-1\/PD-L1\u963b\u65ad\u6cbb\u7597\u6709\u6548\uff0c\u8fd9\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8fd9\u4e00\u6982\u5ff5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7a81\u53d8\u8d1f\u8377\u548c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u53cd\u5e94\u4e4b\u95f4\u7684\u5173\u7cfb\u73b0\u5728\u5df2\u7ecf\u5728\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u4e86\u6b63\u5f0f\u7684\u9a8c\u8bc1\u3002\u5728\u63a5\u53d7\u6297PD-1\u6cbb\u7597\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u80bf\u7624\u975e\u540c\u4e49\u7a81\u53d8\u7684\u6570\u91cf\u589e\u52a0\u4e0e\u66f4\u9ad8\u7684ORR\u548c\u6700\u957f\u7684PFS\u76f8\u5173\u3002\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5bf9\u6297CTLA-4\u6cbb\u7597\u7684\u53cd\u5e94\u548c\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u5bf9\u6297PD-L1\u6cbb\u7597\u7684\u53cd\u5e94\u4e5f\u6709\u76f8\u4f3c\u7684\u53d1\u73b0\u3002\u4e5f\u8bb8\u6700\u5f15\u4eba\u6ce8\u76ee\u7684\u4f8b\u5b50\u662f\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u7684\u80bf\u7624(DNA\u4fee\u590d\u673a\u5236\u6709\u7f3a\u9677)\uff0c\u5b83\u4eec\u8868\u73b0\u51fa\u6bd4\u5176\u4ed6\u75c5\u56e0\u7684\u80bf\u7624\u66f4\u9ad8\u7684\u7a81\u53d8\u8d1f\u62c5\u548c\u76f8\u5e94\u7684\u6297PD-1\u6cbb\u7597\u7684ORR\u3002\u867d\u7136\u8fd9\u4e9b\u60a3\u8005\u9884\u540e\u90fd\u6709\u6539\u5584\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u6cbb\u7597\u540e\u7684\u751f\u5b58\u7387\u63d0\u9ad8\u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u5f52\u56e0\u4e8e\u7a81\u53d8\u8d1f\u8377\u7684\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u867d\u7136\u7a81\u53d8\u8d1f\u8377\u901a\u5e38\u4e0e\u9884\u6d4b\u7684\u65b0\u6297\u539f\u76f8\u5173\uff0c\u4f46\u7279\u5b9a\u7684\u65b0\u6297\u539f\u53ef\u80fd\u5e76\u4e0d\u603b\u662f\u5177\u6709\u514d\u75ab\u539f\u6027\u3002\u76ee\u524d\uff0c\u4eba\u4eec\u5bf9\u8bc6\u522b\u4f5c\u4e3a\u5355\u4e2a\u5bbf\u4e3b\u3001\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u6027\u9776\u70b9\u7684\u7279\u5b9a\u65b0\u6297\u539f\u6709\u7740\u6d53\u539a\u7684\u5174\u8da3\u3002\u5bf9\u8fd9\u4e9b\u65b0\u6297\u539f\u7684\u8bc6\u522b\u5c06\u6709\u52a9\u4e8e\u5f00\u53d1\u771f\u6b63\u7684\u4e2a\u6027\u5316\u533b\u5b66\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

23.5.2 \u5206\u5b50\u4e9a\u7fa4<\/p>\n<\/section>\n

\n
\n
\n

\u901a\u8fc7\u5bf9\u7279\u5b9a\u80bf\u7624\u7c7b\u578b\u7684\u5168\u8f6c\u5f55\u6570\u636e\u5206\u6790\uff08\u5982\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\u9879\u76ee\uff09\uff0c\u5bf9\u764c\u75c7\u7c7b\u578b\u4e9a\u5bb6\u65cf(\u6216\u5206\u5b50\u4e9a\u7ec4)\u5df2\u7ecf\u6709\u4e86\u76f8\u5173\u63cf\u8ff0\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u80bf\u7624\u5206\u5b50\u4e9a\u578b\u548c\u5bf9\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u53cd\u5e94\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u4ec5\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\u4e24\u9879\u72ec\u7acb\u7684\u7814\u7a76\u5df2\u7ecf\u63cf\u8ff0\u4e86\u60a3\u6709\u5c3f\u8def\u4e0a\u76ae\u764c\u201c\u7ba1\u8154II\u578b\u201d\u4e9a\u578b\u7684\u60a3\u8005\u5bf9\u6cbb\u7597\u53cd\u5e94\u7684\u673a\u4f1a\u66f4\u9ad8\u3002\u8fd9\u79cd\u7814\u7a76\u5f00\u542f\u4e86\u4e00\u4e2a\u65b0\u5174\u7684\u9886\u57df\uff0c\u5c06\u6765\u53ef\u80fd\u4f1a\u6269\u5c55\u5230\u5176\u4ed6\u764c\u75c7\u7c7b\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

23.5.3 CD8+ <\/sup>TIL<\/p>\n<\/section>\n

\n
\n
\n

\u5927\u91cf\u8bc1\u636e\u652f\u6301\u80bf\u7624\u514d\u75ab\u6d78\u6da6\u7269\u7684\u7ec4\u6210\u548c\u5206\u5e03\u5bf9\u60a3\u8005\u7684\u4e34\u5e8a\u9884\u540e\u6709\u91cd\u8981\u5f71\u54cd\u3002\u8d1d\u8d6b\u7279\u7b49\u4eba\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u5206\u6790\u4e86130\u591a\u7bc7\u8bba\u6587\u4e2d\u7684\u6570\u636e\uff0c\u8868\u660eCD8+<\/sup>\u548cTh1\u5bfc\u5411\u7684TIL\u5bc6\u5ea6\u589e\u52a0\u4e0e20\u591a\u79cd\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u826f\u597d\u4e34\u5e8a\u7ed3\u679c\u4e4b\u95f4\u5448\u6b63\u76f8\u5173\u5173\u7cfb\u3002\u5728\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u548c\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4ee5\u53ca\u5728\u8fdb\u5c55\u671f\u5148\u63a5\u53d7\u6297CTLA -4\u6cbb\u7597\u540e\u63a5\u53d7\u7eb3\u6b66\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0cCD8+<\/sup> TIL\u5bc6\u5ea6\u4e0e\u6297PD -1\u53cd\u5e94\u4e4b\u95f4\u4e5f\u6709\u7c7b\u4f3c\u7684\u76f8\u5173\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6709\u8da3\u7684\u662f\uff0c\u4e24\u9879\u72ec\u7acb\u7814\u7a76\u62a5\u544a\u4e86\u8f6c\u79fb\u6027\u80be\u764c\u4e2dCD8+ <\/sup>TIL\u7684\u6d78\u6da6\u7a0b\u5ea6\u4e0e\u6297PD-1\u7684\u53cd\u5e94\u65e0\u5173\u3002\u8fd9\u53ef\u80fd\u4e0e\u8fd9\u6837\u4e00\u4e2a\u4e8b\u5b9e\u6709\u5173\uff1a\u4e0e\u5927\u591a\u6570\u764c\u75c7\u7c7b\u578b\u4e0d\u540c\uff0c\u80be\u7ec6\u80de\u764c\u4e2d\u7ec6\u80de\u6bd2\u6027CD8+ <\/sup>TIL\u7684\u589e\u52a0\u4e0e\u751f\u5b58\u7387\u964d\u4f4e\u6709\u5173\u3002\u8fd9\u53ef\u80fd\u662f\u7531\u4e8eTIL\u4e0a\u51e0\u79cd\u6291\u5236\u6027\u53d7\u4f53\u7684\u5171\u540c\u8868\u8fbe\u548c\u80bf\u7624\u5185T\u7ec6\u80de\u7684\u591a\u514b\u9686\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

23.5.4 \u57fa\u56e0\u7279\u5f81<\/p>\n<\/section>\n

\n
\n
\n

\u4e00\u4e9b\u6d4b\u8bd5\u6297PD-1\/PD-L1\u8bd5\u5242\u7684\u7814\u7a76\u5df2\u7ecf\u8bc4\u4f30\u4e86\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u764c\u75c7\u4e2d\uff0c\u5927\u91cf\u514d\u75ab\u548c\u975e\u514d\u75ab\u76f8\u5173\u8f6c\u5f55\u7269\u7684\u4e30\u5ea6\u4e0e\u4e34\u5e8a\u7ed3\u679c\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u4e0e\u4ee5\u524d\u7684\u8bc1\u636e\u4e00\u81f4\uff0c\u5728\u51e0\u9879\u7814\u7a76\u4e2d\uff0c\u5e72\u6270\u7d20-\u03b3\u4fe1\u53f7\u76f8\u5173\u57fa\u56e0(\u5982IFNG\u3001CD8A\u3001IDO\u548cCX3CL1)\u7684\u4e0a\u8c03\u4e0e\u6cbb\u7597\u53cd\u5e94\u6709\u5173\u3002\u5176\u4ed6\u4e0e\u4e34\u5e8a\u7ed3\u679c\u76f8\u5173\u7684\u514d\u75ab\u7279\u5f81\u5305\u62ec\u4e0eTCR\u4fe1\u53f7\u548c\u7ec6\u80de\u6bd2\u6027\u514d\u75ab\u53cd\u5e94\u76f8\u5173\u7684\u57fa\u56e0\u3002\u7531\u4e8e\u5e72\u6270\u7d20-\u03b3\u53ef\u4ee5\u8bf1\u5bfcPD-L1\u8f6c\u5f55\uff0c\u56e0\u6b64\u6709\u7406\u7531\u8ba4\u4e3a\u8868\u73b0\u51fa\u5e72\u6270\u7d20-\u03b3\u57fa\u56e0\u7279\u5f81\u7684\u80bf\u7624\u53ef\u80fd\u4e0e\u8868\u8fbePD-L1\u86cb\u767d\u7684\u80bf\u7624\u91cd\u53e0\uff0c\u5373\u8fd9\u4e24\u79cd\u65b9\u6cd5\u53ef\u4ee5\u5927\u81f4\u8bc6\u522b\u540c\u4e00\u7ec4\u80bf\u7624\u3002\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u7279\u5f81\u7684\u9a8c\u8bc1\u76ee\u524d\u6b63\u5728\u7d27\u5f20\u7684\u7814\u7a76\u4e2d\uff0c\u57fa\u4e8e\u8fd9\u79cd\u65b9\u6cd5\u4f30\u8ba1\u60a3\u8005\u5bf9\u6297PD-1\/PD-L1\u836f\u7269\u654f\u611f\u6027\u7684\u5546\u4e1a\u8bd5\u5242\u6709\u671b\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u95ee\u4e16\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u4e0e\u62b5\u6297PD-1\u963b\u65ad\u76f8\u5173\u7684\u57fa\u56e0\u7279\u5f81\u4e5f\u5df2\u6709\u62a5\u9053\u3002\u4f8b\u5982\uff0c\u4e0e\u5bf9\u6297PD-1\u654f\u611f\u7684\u9ed1\u8272\u7d20\u7624\u76f8\u6bd4\uff0c\u62b5\u6297\u6d3e\u59c6\u5355\u6297\u7684\u9ed1\u8272\u7d20\u7624\u8fc7\u5ea6\u8868\u8fbe\u4e86\u53c2\u4e0e\u95f4\u8d28\u8f6c\u5316\uff08\u5982AXL\u548cROR2\uff09\u3001\u514d\u75ab\u6291\u5236\uff08\u5982IL10\u548cVEGFA\uff09\u4ee5\u53ca\u5355\u6838\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u87af\u5408\u4f5c\u7528\uff08\u5982CCL2\u548cCCL13\uff09\u7684\u57fa\u56e0\u3002\u975e\u514d\u75ab\u76f8\u5173\u9014\u5f84\u4e5f\u53ef\u80fd\u6709\u52a9\u4e8e\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u6709\u6548\u6027\u3002\u4f8b\u5982\uff0c\u5bf9\u6297PD-1\u6cbb\u7597\u6709\u62b5\u6297\u529b\u7684PD-L1(+)\u80be\u7ec6\u80de\u764c\u8fc7\u5ea6\u8868\u8fbe\u53c2\u4e0e\u4ee3\u8c22\u548c\u6eb6\u8d28\u8fd0\u8f93\u529f\u80fd\u7684\u57fa\u56e0\uff0c\u5982UGT1A\u3002 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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23.5.5 T\u7ec6\u80de\u8c31\u7cfb<\/p>\n<\/section>\n

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\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\u5f88\u53ef\u80fd\u4e0e\u589e\u5f3a\u9488\u5bf9\u80bf\u7624\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u65b0\u6297\u539f\u7684\u539f\u4f4d\u7ec6\u80de\u6bd2\u514d\u75ab\u53cd\u5e94\u6709\u5173\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8bb8\u591a\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u8fd9\u4e9b\u836f\u7269\u7684\u6cbb\u7597\u4fc3\u8fdb\u4e86CD8+<\/sup>TIL\u6d41\u5165\u80bf\u7624\uff0c\u5e76\u4f34\u968f\u7740T\u7ec6\u80de\u8c31\u7cfb\u7684\u7624\u5185\u548c\u5916\u5468\u53d8\u5316\u3002\u56e0\u6b64\uff0cT\u7ec6\u80de\u514b\u9686\u6027\u6307\u6570(\u8861\u91cf\u72ec\u7279\u7684TCR CDR3\u53ef\u53d8\u5e8f\u5217\u7684\u6570\u91cf\u548c\u4e30\u5ea6)\u88ab\u8ba4\u4e3a\u662f\u5bf9\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53cd\u5e94\u7684\u4e00\u4e2a\u6f5c\u5728\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u5bf9\u4e8e\u63a5\u53d7\u6297CTLA-4\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u6cbb\u7597\u524d\u80bf\u7624\u6807\u672c\u6216\u6cbb\u7597\u5f00\u59cb\u540e\u5916\u5468\u8840\u4e2d\u7684\u4f4e\u514b\u9686\u53cd\u5e94\uff0c\u5373T\u7ec6\u80de\u8c31\u7cfb\u591a\u6837\u6027\u8f83\u4f4e\uff0c\u4e0e\u53cd\u5e94\u76f8\u5173\u3002\u4e0e\u65e0\u53cd\u5e94\u8005\u76f8\u6bd4\uff0c\u5bf9\u6297PD-1\u6709\u53cd\u5e94\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e5f\u8868\u73b0\u51fa\u66f4\u591a\u7684\u514b\u9686\u6027T\u7ec6\u80de\u7fa4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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23.5.6 \u5916\u5468\u8840\u6807\u5fd7\u7269<\/p>\n<\/section>\n

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\u5982\u4e0a\u6240\u8ff0\uff0c\u5e72\u6270\u7d20-\u03b3\u9a71\u52a8\u7684PD-L1\u5728\u5c40\u90e8\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u8868\u8fbe\u5df2\u88ab\u8bc1\u660e\u4e0e\u6297PD-1\u7684\u53cd\u5e94\u6709\u5173\u3002\u5e72\u6270\u7d20-\u03b3\u53cd\u5e94\u5143\u4ef6\uff0c\u5982\u5916\u5468\u8840T\u7ec6\u80de\u4e0a\u7684BIM\u8868\u8fbe\uff0c\u4e5f\u88ab\u89c2\u5bdf\u5230\u5728\u7ecf\u5386\u6297PD-1\u4e34\u5e8a\u76ca\u5904\u7684\u60a3\u8005\u4e2d\u9ad8\u6c34\u5e73\u8868\u8fbe\u3002\u6700\u8fd1\uff0c\u4e00\u7bc7\u8bc4\u4ef7\u963f\u7279\u4e3d\u73e0\u5355\u6297\u5728\u8f6c\u79fb\u6027RCC\u548c\u665a\u671f\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u6d3b\u6027\u7684\u6587\u7ae0\u63cf\u8ff0\u4e86\u8840\u6e05\u4e2d\u4e00\u4e9b\u7ec6\u80de\u56e0\u5b50\u548c\u6025\u6027\u671f\u86cb\u767d\u7684\u6d53\u5ea6\u53ef\u80fd\u4e0e\u6cbb\u7597\u53cd\u5e94\u6709\u5173 \u3002\u53e6\u4e00\u4e2a\u53ef\u4ee5\u5728\u60a3\u8005\u8840\u6e05\u4e2d\u8bc4\u4f30\u7684\u53c2\u6570\u662f\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u6c34\u5e73\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0cctDNA\u6c34\u5e73\u4e0e\u63a5\u53d7\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e34\u5e8a\u548c\u653e\u5c04\u7ed3\u679c\u76f8\u5173\uff0c\u4f46\u5176\u4f5c\u4e3a\u4e34\u5e8a\u53cd\u5e94\u7684\u751f\u7269\u6807\u5fd7\u7269\u7684\u6709\u6548\u6027\u5c1a\u672a\u5f97\u5230\u6b63\u5f0f\u6d4b\u8bd5\u3002\u7531\u4e8e\u5916\u5468\u91c7\u8840\u7684\u5fae\u521b\u6027\u8d28\uff0c\u4ee5\u53ca\u57fa\u4e8e\u8840\u6db2\u7684\u68c0\u6d4b\u5728\u5e38\u89c4\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u76f8\u5bf9\u5bb9\u6613\u5b9e\u73b0\u7684\u53ef\u80fd\u6027\uff0c\u8fd9\u4e00\u9886\u57df\u53d7\u5230\u7279\u522b\u5bc6\u5207\u7684\u5173\u6ce8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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23.6 \u7ed3\u8bba\u548c\u672a\u6765\u65b9\u5411<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5927\u591a\u6570\u7814\u7a76\u8868\u660e\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u5e72\u9884\u540e\uff0c\u5bf9\u80bf\u7624\u7684\u539f\u4f4d\u514d\u75ab\u5e94\u7b54\u589e\u52a0\u4e0e\u4e34\u5e8a\u7ed3\u679c\u4e4b\u95f4\u5b58\u5728\u5f3a\u70c8\u7684\u76f8\u5173\u6027\u3002\u5c40\u90e8PD-L1\u86cb\u767d\u8868\u8fbe\u3001\u9ad8\u7a81\u53d8\u8d1f\u8377\u3001TIL\u6d78\u6da6\u589e\u52a0\u3001\u4ee5\u5e72\u6270\u7d20-\u03b3\u4e3a\u5bfc\u5411\u7684\u57fa\u56e0\u4fe1\u53f7\u8fc7\u5ea6\u8868\u8fbe\u662f\u6700\u5177\u5b9e\u9a8c\u652f\u6301\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u5927\u591a\u6570\u8bc4\u4f30\u8fd9\u4e9b\u53c2\u6570\u7684\u7814\u7a76\u9700\u8981\u5728\u66f4\u591a\u7684\u764c\u75c7\u7c7b\u578b\u4e2d\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u548c\u6269\u5c55\u6d4b\u8bd5\u3002\u867d\u7136\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5927\u591a\u6570\u7684\u7126\u70b9\u90fd\u96c6\u4e2d\u5728\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u4e0a\uff0c\u4f46\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u7fa4\uff0c\u5982B\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\uff0c\u4e5f\u53ef\u4ee5\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u7684\u6d88\u9664\u3002\u6b64\u5916\uff0c\u8c03\u8282\u6027T\u7ec6\u80de\u548c\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u7ec6\u80de\u7b49\u7fa4\u4f53\u53ef\u4ee5\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u4fc3\u8fdb\u6076\u6027\u7ec6\u80de\u751f\u957f\u548c\u7ec4\u7ec7\u4fb5\u88ad\u3002\u591a\u91cd\u514d\u75ab\u8367\u5149\u6216\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u7b49\u65b0\u6280\u672f\u5c06\u5141\u8bb8\u540c\u65f6\u8bc6\u522b\u3001\u8ba1\u6570\u548c\u8bc4\u4f30\u4f17\u591a\u7ec6\u80de\u79cd\u7fa4\u4e4b\u95f4\u7684\u4f4d\u7f6e\u5173\u7cfb\uff0cFig. 23.4<\/span>\u3002\u672a\u6765\u7684\u7814\u7a76\u5c06\u96c6\u4e2d\u5728\u5c06\u8fd9\u79cd\u7a7a\u95f4\u86cb\u767d\u8868\u8fbe\u4e0e\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u6807\u8bb0\u6574\u5408\u65b9\u9762\uff0c\u4ee5\u6539\u8fdb\u60a3\u8005\u9009\u62e9\u3001\u6cbb\u7597\u76d1\u6d4b\u548c\u6cbb\u7597\u836f\u7269\u7ed9\u836f\u7684\u9002\u5e94\u6027\u8c03\u6574\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 23.4<\/span> \u798f\u5c14\u9a6c\u6797\u56fa\u5b9a\u77f3\u8721\u5305\u57cb\u7684\u9ed1\u8272\u7d20\u7624\u6807\u672c\u7528\u591a\u5149\u8c31\u514d\u75ab\u8367\u5149\u67d3\u8272\u5e76\u6210\u50cf\u3002\u8be5\u65b9\u6cd5\u6709\u52a9\u4e8e\u540c\u65f6\u89c2\u5bdf\u4e0d\u540c\u7684\u7ec6\u80de\u4e9a\u7fa4\u548c\u5728\u540c\u4e00\u8f7d\u73bb\u7247\u4e0a\u5171\u8868\u8fbe\u7684\u7814\u7a76\u3002\u56fe\u793a\u4e3a\u7ec6\u80de\u6bd2\u6027CD8+T\u7ec6\u80de(\u84dd\u8272)\u3001FoxP3+\u8c03\u8282\u6027T\u7ec6\u80de(\u7ea2\u8272)\u3001CD68+\u5de8\u566c\u7ec6\u80de(\u6d0b\u7ea2\u8272)\u548cSox10+\u9ed1\u8272\u7d20\u7624\u7ec6\u80de(\u6a59\u8272)\u3002PD-L1(AquA)\u5728\u80bf\u7624\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u6dcb\u5df4\u7ec6\u80de\u4e0a\u7684\u8868\u8fbe\u4e0eCD8+\u548cFoxP3+T\u7ec6\u80de\u7684PD-1\u8868\u8fbe\u975e\u5e38\u63a5\u8fd1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Nicolas A. Giraldo and Janis M. Taube<\/span><\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u7f57\u4f73\u4f73 \u7ae0\u9707<\/span><\/span><\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u675c\u8f7b\u677e<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764 \u80e1\u73ca<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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