{"id":5226,"date":"2023-08-14T21:10:29","date_gmt":"2023-08-14T13:10:29","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/14\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac24%e7%ab%a0%ef%bc%9a%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%ef%bc%9at-vec%e5%92%8c%e5%85%b6%e4%bb%96%ef%bc%88%e4%b8%8a%ef%bc%89\/"},"modified":"2023-08-14T21:10:29","modified_gmt":"2023-08-14T13:10:29","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac24%e7%ab%a0%ef%bc%9a%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%ef%bc%9at-vec%e5%92%8c%e5%85%b6%e4%bb%96%ef%bc%88%e4%b8%8a%ef%bc%89","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/08\/14\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac24%e7%ab%a0%ef%bc%9a%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%ef%bc%9at-vec%e5%92%8c%e5%85%b6%e4%bb%96%ef%bc%88%e4%b8%8a%ef%bc%89\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c24\u7ae0\uff1a\u6eb6\u7624\u75c5\u6bd2\uff1aT-VEC\u548c\u5176\u4ed6\uff08\u4e0a\uff09"},"content":{"rendered":"
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24.1 \u80cc\u666f\u4ecb\u7ecd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u6cbb\u7597\u5df2\u6210\u4e3a\u9ed1\u8272\u7d20\u7624\u3001\u80ba\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u7b49\u591a\u79cd\u665a\u671f\u764c\u75c7\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u6dcb\u5df4\u7ec6\u80de\u4e30\u5bcc\u7684\u80bf\u7624\u5fae\u73af\u5883\u662f\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u9884\u6d4b\u56e0\u7d20\u3002<\/p>\n

\u5c3d\u7ba1\u4ece\u7406\u8bba\u4e0a\u8bb2\uff0c\u8fd9\u4e9b\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u5e94\u8be5\u5177\u6709\u5f88\u9ad8\u7684\u514d\u75ab\u539f\u6027\uff0c\u4f46\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u5fae\u73af\u5883\u672c\u8eab\u5177\u6709\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u800c\u80bf\u7624\u76f8\u5173\u6297\u539f\uff08TAAs\uff09\u7684\u514d\u75ab\u539f\u6027\u5f88\u5f31\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5927\u591a\u6570\u80bf\u7624\u7c7b\u578b\u7684\u81ea\u53d1\u6027\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u3002<\/p>\n

\u56e0\u6b64\uff0c\u6539\u53d8\u80bf\u7624\u751f\u957f\u548c\u514d\u75ab\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e4b\u95f4\u7684\u5e73\u8861\uff0c\u540c\u65f6\u63d0\u9ad8\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u5e45\u5ea6\u7684\u7b56\u7565\u662f\u975e\u5e38\u9700\u8981\u7684\u3002\u76ee\u524d\u7684\u8bb8\u591a\u514d\u75ab\u7597\u6cd5\uff0c\u5982\u4f0a\u5339\u5355\u6297\u3001\u6d3e\u59c6\u5355\u6297\u548c\u7eb3\u6b66\u5355\u6297\u7b49\uff0c\u90fd\u5f71\u54cd\u4e86\u8fd9\u4e9b\u514d\u75ab\u8c03\u8282\u901a\u8def\u7684\u5173\u952e\u56e0\u7d20\uff0c\u5982CTLA-4\u548cPD-1\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u6297\u80bf\u7624\u514d\u75ab\u3002<\/p>\n

\u4f7f\u7528\u4f0a\u5339\u5355\u6297\u963b\u65adCTLA-4\u548c\u4f7f\u7528\u6d3e\u59c6\u5355\u6297\u6216\u7eb3\u6b66\u5355\u6297\u963b\u65adPD-1\u53ef\u5206\u522b\u4ea7\u751f11%-15%\u548c30%-40%\u7684\u5e94\u7b54\u7387\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u5bfb\u6c42\u4f0a\u5339\u5355\u6297\u548c\u7eb3\u6b66\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\u3002\u5c3d\u7ba1\u5e94\u7b54\u7387\u8fdc\u9ad8\u4e8e\u5355\u72ec\u7528\u836f\uff0c\u4f46\u7531\u4e8e\u53cc\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\uff0c\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u4e5f\u6709\u6240\u4e0a\u5347\u3002\u56e0\u6b64\uff0c\u5177\u6709\u826f\u597d\u4e34\u5e8a\u6d3b\u6027\u540c\u65f6\u6bd2\u6027\u8f83\u4f4e\u7684\u7597\u6cd5\u975e\u5e38\u503c\u5f97\u671f\u5f85\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.1.1 \u4ec0\u4e48\u662f\u6eb6\u7624\u75c5\u6bd2\uff1f<\/p>\n<\/section>\n

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\u80bf\u7624\u6eb6\u89e3\u75c5\u6bd2\u5305\u62ec\u672a\u4fee\u9970\u7684\u91ce\u751f\u578b\u548c\u57fa\u56e0\u5de5\u7a0b\u5236\u5242\uff0c\u53ef\u9009\u62e9\u6027\u5730\u611f\u67d3\u80bf\u7624\u7ec6\u80de\u5e76\u5728\u80bf\u7624\u7ec6\u80de\u5185\u590d\u5236\uff0c\u5bfc\u81f4\u611f\u67d3\u7ec6\u80de\u88c2\u89e3\u3002\u6b64\u5916\uff0c\u80bf\u7624\u88c2\u89e3\u91ca\u653e\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u80bf\u7624\u884d\u751f\u6297\u539f\u53ef\u89e6\u53d1\u514d\u75ab\u7cfb\u7edf\u5e76\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u3002\u6eb6\u7624\u75c5\u6bd2\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u662f\u6709\u7528\u7684\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0d\u4ec5\u5bf9\u764c\u7ec6\u80de\u5177\u6709\u5148\u5929\u7684\u55dc\u6027\u5e76\u5bfc\u81f4\u80bf\u7624\u6b7b\u4ea1\uff0c\u800c\u4e14\u91ca\u653e\u7684TAAs\u53ef\u4f5c\u4e3a\u589e\u5f3a\u80bf\u7624\u7279\u5f02\u6027\u6297\u80bf\u7624\u514d\u75ab\u7684\u9776\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.1.2 \u6eb6\u7624\u75c5\u6bd2\u53f2<\/p>\n<\/section>\n

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\u751a\u81f3\u5728\u6eb6\u7624\u75c5\u6bd2\u88ab\u8bbe\u8ba1\u6216\u4f7f\u7528\u4e4b\u524d\uff0c\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u65e9\u572820\u4e16\u7eaa50\u5e74\u4ee3\u4e2d\u671f\u5c31\u89c2\u5bdf\u5230\u4e00\u4e9b\u75c5\u6bd2\u5177\u6709\u611f\u67d3\u6027\uff0c\u4ece\u800c\u5bfc\u81f4\u4f53\u5916\u5916\u5468\u8840\u767d\u8840\u75c5\u7ec6\u80de\u6b7b\u4ea1\u3002\u6b64\u5916\uff0c\u5386\u53f2\u4e0a\u66fe\u6709\u7814\u7a76\u8868\u660e\uff0c\u6c34\u75d8\u3001\u9ebb\u75b9\u6216\u809d\u708e\u5bfc\u81f4\u7684\u75c5\u6bd2\u7efc\u5408\u5f81\u53ef\u4f7f\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\u7b49\u665a\u671f\u6076\u6027\u80bf\u7624\u7f13\u89e3\u3002<\/p>\n

1949\u5e74\uff0c22\u4f8b\u970d\u5947\u91d1\u75c5\u60a3\u8005\u63a5\u53d7\u4e86\u542b\u6709\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u7684\u4eba\u8840\u6e05\u80a0\u5916\u6ce8\u5c04\u6cbb\u7597\uff0c\u5176\u4e2d13\u4f8b\u51fa\u73b0\u611f\u67d3\u3002\u5176\u4e2d7\u4f8b\u51fa\u73b0\u90e8\u5206\u6297\u80bf\u7624\u53cd\u5e94\u30021952\u5e74\uff0c34\u4f8b\u665a\u671f\u96be\u6cbb\u6027\u80bf\u7624\u60a3\u8005\u63a5\u53d7\u4e86\u57c3\u53ca101\u75c5\u6bd2\u6cbb\u7597\uff0c\u7ed3\u679c\u53d1\u73b04\/34\u7684\u60a3\u8005\u51fa\u73b0\u6682\u65f6\u6027\u80bf\u7624\u6d88\u9000\u30021956\u5e74\uff0c\u817a-\u54bd-\u7ed3\u819c\uff08APC\uff09\u75c5\u6bd2\u7528\u4e8e\u6cbb\u759730\u4f8b\u5bab\u9888\u764c\u60a3\u8005\uff0c\u5176\u4e2d26\u4f8b\u51fa\u73b0\u6297\u80bf\u7624\u53cd\u5e94\u30021967\u5e74\uff0cLindenmann\u548cKlein\u5bf9\u6eb6\u7624\u75c5\u6bd2\u8fdb\u884c\u4e86\u5b9a\u70b9\u7814\u7a76\uff0c\u8bc1\u660e\u6d41\u611f\u75c5\u6bd2\u7684\u75c5\u6bd2\u7597\u6cd5\u53ef\u589e\u5f3a\u80bf\u7624\u7ec6\u80de\u6297\u539f\u7684\u514d\u75ab\u539f\u6027\u300220\u4e16\u7eaa70\u5e74\u4ee3\uff0cAsada\u8bc1\u5b9e40%\u4ee5\u4e0a\u7684\u665a\u671f\u764c\u75c7\u60a3\u8005\u63a5\u53d7\u975e\u51cf\u6bd2\u816e\u817a\u708e\u75c5\u6bd2\u6cbb\u7597\u540e\u4ea7\u751f\u6297\u80bf\u7624\u53cd\u5e94\u30021999\u5e74\u665a\u4e9b\u65f6\u5019\uff0cMartuza\u3001Toda\u548c\u5176\u4ed6\u4eba\u53d1\u73b0HSV G207\uff08\u4e00\u79cd\u57fa\u56e0\u5de5\u7a0b\u6eb6\u7624\u75c5\u6bd2\uff09\u5728CT26\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u3002\u76ee\u524d\uff0c\u6b63\u5728\u5bf9\u51e0\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u75c5\u6bd2\u8fdb\u884c\u591a\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.1.3 \u8fd9\u79cd\u7597\u6cd5\u7279\u5f81\u662f\u4ec0\u4e48\uff1f<\/p>\n<\/section>\n

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\u80bf\u7624\u9009\u62e9\u6027\u548c\u901a\u8fc7\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u91ca\u653e TAAs \u4e0e\u5176\u4ed6\u4fe1\u53f7\u548c\u7ec6\u80de\u56e0\u5b50\u5171\u540c\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u662f\u6eb6\u7624\u75c5\u6bd2\u7684\u7279\u70b9\u3002\u4e0eTAAs\u5171\u540c\u53d1\u6325\u4f5c\u7528\u7684\u4fe1\u53f7\u662f\u635f\u4f24\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff08DAMP\uff09\u548c\u6eb6\u7624\u75c5\u6bd2\u884d\u751f\u7684\u75c5\u539f\u4f53\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff08PAMP\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7531\u4e8e\u6eb6\u7624\u75c5\u6bd2\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u56e0\u6b64\u8fd9\u79cd\u7597\u6cd5\u53ef\u80fd\u4f1a\u4ea7\u751f\u6301\u4e45\u7684\u53cd\u5e94\u3002\u9274\u4e8e\u6eb6\u7624\u75c5\u6bd2\u9488\u5bf9\u591a\u79cd\u81f4\u764c\u9014\u5f84\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027\uff0c\u4ea7\u751f\u6297\u836f\u6027\u7684\u53ef\u80fd\u6027\u8f83\u5c0f\u3002\u4e0e\u68c0\u67e5\u70b9\u963b\u65ad\u6291\u5236\u5242\u7b49\u5927\u591a\u6570\u514d\u75ab\u7597\u6cd5\u4e0d\u540c\u7684\u662f\uff0c\u7279\u5f02\u7684\u80bf\u7624\u9009\u62e9\u6027\u53ef\u4f7f\u5168\u8eab\u6bd2\u6027\u8fbe\u5230\u6700\u5c0f\u3002<\/p>\n

\u8fd9\u4e9b\u75c5\u6bd2\u5927\u591a\u662f\u4f5c\u4e3a\u7624\u5185\u7597\u6cd5\u5f00\u53d1\u7684\uff0c\u4f46\u4e5f\u6709\u5c11\u6570\u53ef\u7528\u4e8e\u5168\u8eab\u3002\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u9762\u4e34\u7684\u4e00\u4e2a\u7279\u6b8a\u6311\u6218\u662f\u65e0\u6cd5\u6709\u6548\u5730\u5c06\u8fd9\u4e9b\u75c5\u6bd2\u8f93\u9001\u5230\u80bf\u7624\u7ed3\u8282\uff0c\u5e76\u8fdb\u4e00\u6b65\u6269\u6563\u5230\u8fdc\u5904\u7684\u5fae\u8f6c\u79fb\u7076\uff0c\u4ece\u800c\u9650\u5236\u4e86\u5176\u7597\u6548\u3002\u6297\u6eb6\u7624\u75c5\u6bd2\u6297\u4f53\u53ef\u80fd\u4f5c\u4e3a\u4eba\u4f53\u8840\u6e05\u4e2d\u5148\u5929\u6027\u514d\u75ab\u7684\u4e00\u90e8\u5206\u9884\u5148\u5b58\u5728\uff0c\u6216\u56e0\u591a\u6b21\u4f7f\u7528\u8fd9\u79cd\u7597\u6cd5\u800c\u4ea7\u751f\uff0c\u8fd9\u4e9b\u90fd\u4f1a\u9650\u5236\u6eb6\u7624\u75c5\u6bd2\u5728\u5168\u8eab\u7684\u4f7f\u7528\u3002\u6b64\u5916\uff0c\u6eb6\u7624\u75c5\u6bd2\u5728\u80bf\u7624\u5185\u4e0d\u6613\u5916\u6e17\uff0c\u5e76\u4e14\u4f1a\u88ab\u809d\u810f\u9694\u79bb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6eb6\u7624\u75c5\u6bd2\u7684\u6cbb\u7597\u6548\u679c\u901a\u8fc7\u75c5\u6bd2\u8131\u843d\u3001\u7624\u5185\u75c5\u6bd2\u590d\u5236\u3001\u75c5\u6bd2\u8840\u75c7\u3001\u75c5\u6bd2\u57fa\u56e0\u7ec4\u3001\u75c5\u6bd2\u8f7d\u91cf\u3001\u514d\u75ab\u6d78\u6da6\u548c\u5faa\u73af\u514d\u75ab\u7ec6\u80de\u7b49\u6307\u6807\u76d1\u6d4b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.1.4 \u6eb6\u7624\u75c5\u6bd2\u7684\u4f5c\u7528\u673a\u5236<\/p>\n<\/section>\n

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\u6eb6\u7624\u75c5\u6bd2\u5bf9\u80bf\u7624\u7684\u9009\u62e9\u6027\u4f9d\u8d56\u51e0\u4e2a\u56e0\u7d20\u7684\u5f71\u54cd\u3002<\/p>\n

\u9996\u5148\uff0c\u5b58\u5728\u53d7\u4f53\u4ecb\u5bfc\u7684\u75c5\u6bd2\u7279\u5f02\u6027\u7ec6\u80de\u8fdb\u5165\uff0c\u5176\u81ea\u7136\u9776\u5411\u80bf\u7624\u7ec6\u80de\u8868\u8fbe\u53d7\u4f53\uff0c\u5982\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u3001\u53f6\u9178\u53d7\u4f53\u3001Her2-neu\u3001\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\u3001CD20\u3001COX-2\u548c\u7834\u9aa8\u7ec6\u80de\u7d20\u7b49\uff0c\u6216\u8005\u75c5\u6bd2\u53ef\u4ee5\u901a\u8fc7\u8fd9\u4e9b\u53d7\u4f53\u88ab\u5de5\u7a0b\u5316\u4ee5\u7279\u5f02\u6027\u9776\u5411\u764c\u7ec6\u80de\u3002CD155\u88ab\u8ba4\u4e3a\u662f\u810a\u9ad3\u7070\u8d28\u708e\u75c5\u6bd2\u53d7\u4f53\uff0c\u5b58\u5728\u4e8e\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u7ec6\u80de\u4e0a\uff0c\u5e76\u4fc3\u8fdb\u810a\u9ad3\u7070\u8d28\u75c5\u6bd2\u8fdb\u5165\u3002<\/p>\n

\u5176\u6b21\uff0c\u80bf\u7624\u7ec6\u80de\u7b49\u4ee3\u8c22\u6d3b\u8dc3\u7684\u7ec6\u80de\u4e3a\u6eb6\u7624\u75c5\u6bd2\u63d0\u4f9b\u4e86\u826f\u597d\u7684\u590d\u5236\u573a\u6240\u3002\u80bf\u7624\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u4e5f\u80fd\u4e13\u95e8\u5e2e\u52a9\u75c5\u6bd2\u590d\u5236\u3002\u817a\u75c5\u6bd2\u5728 S \u671f\u8fdb\u884c\u7279\u5f02\u6027\u590d\u5236\u3002\u91ce\u751f\u578b\u75c5\u6bd2\u7f16\u7801 E1A \u86cb\u767d\uff0c\u901a\u8fc7\u89c6\u7f51\u819c\u6bcd\u7ec6\u80de\u7624\u4fe1\u53f7\u8f6c\u5bfc\u4fc3\u8fdb\u75c5\u6bd2\u8fdb\u5165 S \u671f\u3002\u89c6\u7f51\u819c\u6bcd\u7ec6\u80de\u7624\u4fe1\u53f7\u7a81\u53d8\u548c\u5bcc\u96c6\u7684 S \u671f\u7fa4\u4f53\u53ef\u89c1\u4e8e\u8bb8\u591a\u764c\u75c7\u7c7b\u578b\uff1b\u56e0\u6b64\uff0c\u5728\u6eb6\u7624\u53d8\u4f53\u4e2d\u5220\u9664 E1A \u57fa\u56e0\u6709\u52a9\u4e8e\u964d\u4f4e\u5176\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u7684\u81f4\u75c5\u6027 \u3002<\/p>\n

\u7b2c\u4e09\uff0c\u80bf\u7624\u7ec6\u80de\u4e2d\u6297\u75c5\u6bd2 I \u578b\u5e72\u6270\u7d20\u4fe1\u53f7\u7f3a\u9677\u6709\u52a9\u4e8e\u75c5\u6bd2\u590d\u5236\u3002\u547c\u80a0\u5b64\u75c5\u6bd2\u4f18\u5148\u653b\u51fb Ras \u4fe1\u53f7\u6fc0\u6d3b\u7684\u7ec6\u80de\u3002\u4f7f\u764c\u7ec6\u80de\u6613\u53d7\u8fd9\u4e9b\u75c5\u6bd2\u6eb6\u7624\u6548\u5e94\u5f71\u54cd\u7684\u5176\u4ed6\u4e00\u4e9b\u6539\u53d8\u7684\u4fe1\u53f7\u901a\u8def\u5305\u62ec RB\/E2F\/p16\u3001p53\u3001PKR\u3001\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u3001Ras\u3001Wnt\u3001\u6297\u51cb\u4ea1\u3001\u7f3a\u6c27\u3001IFN \u7f3a\u9677\u548c\u5176\u4ed6\u5148\u5929\u514d\u75ab\u4fe1\u53f7\u901a\u8def\u3002\u75c5\u6bd2\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u590d\u5236\u6fc0\u6d3b\u4e86\u5148\u5929\u514d\u75ab\u548c\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u548c\u57fa\u8d28\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\uff08Fig. 24.1\uff09<\/span><\/span>\u3002<\/p>\n

\u764c\u7ec6\u80de\u6b7b\u4ea1\u7684\u5176\u4ed6\u6a21\u5f0f\u6709\uff1a(1) \u75c5\u6bd2\u76f4\u63a5\u6eb6\u89e3\u764c\u7ec6\u80de\uff0c\u8fd9\u53ef\u80fd\u662f\u7ec6\u80de\u51cb\u4ea1\u3001\u574f\u6b7b\u3001\u70ed\u89e3\u6216\u81ea\u566c\u7684\u7ed3\u679c\uff0c\u591a\u6570\u60c5\u51b5\u4e0b\u662f\u7efc\u5408\u4f5c\u7528\u7684\u7ed3\u679c\uff1b(2) \u6eb6\u7624\u75c5\u6bd2\u7684\u6297\u8840\u7ba1\u751f\u6210\u7279\u6027\u53ef\u5bfc\u81f4\u672a\u611f\u67d3\u7ec6\u80de\u7684\u574f\u6b7b\u548c\u51cb\u4ea1\u3002\u4e0e\u6b64\u7c7b\u4f3c\uff0c\u9488\u5bf9\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u63d0\u51fa\u7684\u6297\u836f\u6027\u673a\u5236\u662f\u5bbf\u4e3b\u4f53\u5185\u5b58\u5728\u4e2d\u548c\u6297\u4f53\u4ee5\u53ca\u9488\u5bf9\u6eb6\u7624\u75c5\u6bd2\u7684\u5148\u5929\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.1.5 \u6eb6\u7624\u75c5\u6bd2\u7684\u7c7b\u578b<\/p>\n<\/section>\n

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\u6eb6\u7624\u75c5\u6bd2\u6709\u4e24\u79cd\u7c7b\u578b\uff1a(1)\u7531\u4e8e\u4f9d\u8d56\u81f4\u764c\u4fe1\u53f7\u901a\u8def\u6216\u5bf9\u5148\u5929\u6027\u6297\u75c5\u6bd2\u4fe1\u53f7\u654f\u611f\u6027\u63d0\u9ad8\uff0c\u4f18\u5148\u5728\u764c\u7ec6\u80de\u4e2d\u590d\u5236\uff0c\u800c\u975e\u81f4\u75c5\u7ec6\u80de\u4e0d\u53d7\u5f71\u54cd\uff1b(2)\u7ecf\u8fc7\u57fa\u56e0\u64cd\u4f5c\u548c\/\u6216\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\uff0c\u63d2\u5165\u6216\u7f3a\u5931\u5728\u6b63\u5e38\u7ec6\u80de\u800c\u975e\u764c\u7ec6\u80de\u4e2d\u590d\u5236\u6240\u9700\u7684\u57fa\u56e0\u7684\u75c5\u6bd2\u3002<\/p>\n

\u81ea\u4e3b\u526f\u75c5\u6bd2\u3001\u808c\u7624\u75c5\u6bd2\uff08\u75d8\u75c5\u6bd2\uff09\u3001\u65b0\u57ce\u75ab\u75c5\u6bd2\uff08\u526f\u7c98\u75c5\u6bd2\uff09\u3001\u518d\u75c5\u6bd2\u548c\u585e\u5185\u5361\u8c37\u75c5\u6bd2\uff08\u76ae\u5361\u75c5\u6bd2\uff09\u90fd\u662f\u5728\u764c\u7ec6\u80de\u4e2d\u590d\u5236\u7684\u7279\u5f02\u6027\u75c5\u6bd2\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u9ebb\u75b9\u75c5\u6bd2\uff08\u526f\u9ecf\u6db2\u75c5\u6bd2\uff09\u3001\u810a\u9ad3\u7070\u8d28\u708e\u75c5\u6bd2\uff08\u76ae\u5361\u75c5\u6bd2\uff09\u3001\u75ab\u82d7\u75c5\u6bd2\uff08\u75d8\u75c5\u6bd2\uff09\u3001\u817a\u75c5\u6bd2\u3001\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u548c\u6c34\u6ce1\u6027\u53e3\u708e\u75c5\u6bd2\u7b49\u75c5\u6bd2\u5219\u662f\u901a\u8fc7\u57fa\u56e0\u64cd\u4f5c\u6216\u5de5\u7a0b\u6280\u672f\u5236\u9020\u7684\u3002<\/p>\n

\u76ee\u524d\u6b63\u5728\u5bf9\u51e0\u79cd\u6eb6\u7624\u75c5\u6bd2\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u552f\u4e00\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u53ca\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u662f\u63d0\u53d6\u81ea HSV-1 \u7684 Talimogene laherparepvec\uff08T-VEC\uff09\uff0c\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3002\u5176\u4ed6\u6b63\u5728\u5f00\u53d1\u7684\u7597\u6cd5\u5305\u62ec\u67ef\u8428\u5947\u75c5\u6bd2\uff08CVA21\uff09\u3001\u817a\u75c5\u6bd2\uff08K901\u3001CG0070\uff09\u3001\u75ab\u82d7\uff08JX-594\u3001GM-CSF RV\u3001Pexa-Vec\uff09\u548c\u91cd\u7ec4\u75c5\u6bd2\uff08pelareorep\u3001REOLYSIN\u00ae\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig. 24.1<\/span>\u6eb6\u7624\u75c5\u6bd2\u7684\u4f5c\u7528\u673a\u5236\uff1a\u764c\u7ec6\u80de\u4e2d\u7684\u9009\u62e9\u6027\u590d\u5236\u3001\u80bf\u7624\u6eb6\u89e3\u3001\u75c5\u6bd2\u91ca\u653e\uff0c\u4ee5\u53ca\u764c\u7ec4\u7ec7\u5185\u7684\u6269\u6563\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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24.2 T-VEC<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.2.1 \u4ec0\u4e48\u662fT-VEC<\/p>\n<\/section>\n

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Talimogene laherparepvec\uff08T-VEC\uff09\u4ee5\u524d\u4e5f\u79f0\u4e3a OncoVEXGM-CSF\uff0c\u662f\u4e00\u79cd\u6539\u826f\u7684\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2 1 \u578b\u884d\u751f\u7684\u6eb6\u7624\u514d\u75ab\u7597\u6cd5\uff0c\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u9ed1\u8272\u7d20\u7624\u7684\u7624\u5185\u6cbb\u7597\u3002\u76ee\u524d\u6b63\u5728\u5f00\u53d1\u7528\u4e8e\u591a\u79cd\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.2.2 T-VEC\u7684\u7ed3\u6784\u548c\u53ef\u80fd\u4f5c\u7528\u673a\u5236<\/p>\n<\/section>\n

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\u8fd9\u79cd\u6eb6\u7624\u75c5\u6bd2\u6e90\u81ea HSV-1\u3002\u9274\u4e8e HSV-1 \u7684\u7279\u5f81\u5341\u5206\u660e\u786e\uff0c\u5176\u751f\u7269\u5b66\u7279\u6027\u4e5f\u5e7f\u4e3a\u4eba\u77e5\uff0c\u56e0\u6b64\u662f\u4e00\u79cd\u5408\u9002\u7684\u8f7d\u4f53\u3002\u5b83\u7684\u5927\u578b\u975e\u6574\u5408\u53cc\u94fe DNA \u57fa\u56e0\u7ec4\u5f88\u5bb9\u6613\u64cd\u4f5c\uff0c\u53ef\u4ee5\u63d2\u5165\u5927\u91cf\u57fa\u56e0\u3002T-VEC \u7684\u7ed3\u6784\uff08Fig. 24.2<\/span>\uff09\u663e\u793a\u5220\u9664\u4e86\u4e24\u4e2a HSV \u57fa\u56e0\uff1aICP34.5\u548cICP47\u3002ICP34.5 \u8d4b\u4e88 HSV-1 \u795e\u7ecf\u75c5\u6bd2\u6027\u3002\u56e0\u6b64\uff0cICP34.5 \u57fa\u56e0\u7684\u7f3a\u5931\u53ef\u63d0\u4f9b\u9009\u62e9\u6027\u7684\u764c\u7ec6\u80de\u590d\u5236\uff0c\u800c\u7528\u4e24\u4e2a GM-CSF \u57fa\u56e0\u62f7\u8d1d\u66ff\u4ee3\u5219\u53ef\u589e\u5f3a\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\uff09\u7684\u5c40\u90e8\u4ea7\u751f\u3002GM-CSF\u8d1f\u8d23\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u5185\u7684\u6210\u719f\u548c\u62db\u52df\uff0c\u8fd9\u4e9b\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u53cd\u8fc7\u6765\u53c8\u5141\u8bb8\u80bf\u7624\u6297\u539f\u5448\u9012\uff0c\u4ece\u800c\u4ea7\u751f T \u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6548\u5e94\u3002ICP47 \u7684\u7f3a\u5931\u4f1a\u5bfc\u81f4 US11 \u542f\u52a8\u5b50\u7684\u65e9\u671f\u6fc0\u6d3b\uff0c\u4ece\u800c\u589e\u5f3a\u75c5\u6bd2\u590d\u5236\u5e76\u4fc3\u8fdb\u6297\u539f\u5448\u9012\uff0c\u5bfc\u81f4\u66f4\u597d\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94 \u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e\u5176\u4ed6\u6eb6\u7624\u75c5\u6bd2\u7c7b\u4f3c\uff0cT-VEC \u4e5f\u88ab\u8ba4\u4e3a\u5177\u6709\u5c40\u90e8\u548c\u5168\u8eab\u6548\u5e94\uff08Fig.24.3<\/span>\uff09\u3002\u901a\u8fc7\u4e0a\u8ff0\u673a\u5236\uff0cT-VEC \u53ef\u9009\u62e9\u6027\u5730\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u590d\u5236\uff0c\u4ece\u800c\u4ea7\u751f\u6eb6\u7624\u4f5c\u7528\u3002\u8fd9\u53cd\u8fc7\u6765\u53c8\u4f1a\u91ca\u653e\u51fa\u66f4\u591a\u7684\u5b50\u4ee3\u75c5\u6bd2\uff0c\u5468\u800c\u590d\u59cb\u3002\u5728\u4ea7\u751f\u514d\u75ab\u8c03\u8282\u7ec6\u80de\u56e0\u5b50GM-CSF\u7684\u540c\u65f6\uff0c\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u7684\u91ca\u653e\u4f1a\u8bf1\u5bfc\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u62db\u52df\u548c\u6210\u719f\u3002\u80bf\u7624\u7ec6\u80de\u6297\u539f\u5448\u9012\u7ed9 T \u7ec6\u80de\uff0c\u5bfc\u81f4 CD8+<\/sup> T \u7ec6\u80de\u6d3b\u5316\u548c\u6269\u589e\uff0c\u5f15\u8d77\u5168\u8eab\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 24.2<\/span> T-VEC \u57fa\u56e0\u7ec4\u7684\u7ed3\u6784\u3002ICP34.5 \u548c ICP47 \u7684\u5220\u9664\u4f4d\u7f6e\u6807\u8bb0\u4e3a\u039434.5\u548c\u039447\u3002\u7528\u7c89\u7ea2\u8272\u6807\u8bb0\u7684\u533a\u57df\u662f\u63d2\u5165\u4ebaGM-CSF\u57fa\u56e0\u7684\u4f4d\u70b9\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 24.3<\/span> T-VEC \u7684\u4f5c\u7528\u673a\u5236\u3002\u80bf\u7624\u5185\u65bd\u7528 T-VEC\uff081\uff09\u540e\uff0c\u75c5\u6bd2\u5728\u764c\u7ec6\u80de\u4e2d\u9009\u62e9\u6027\u590d\u5236\uff082\uff09\u3002T-VEC \u8fd8\u8868\u8fbe GM-CSF\uff0c\u5176\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6210\u719f\u548c\u529f\u80fd\uff0c\u5f15\u53d1\u7cfb\u7edf\u6027 T \u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u53cd\u5e94\uff083\uff09\u3002\u75c5\u6bd2\u53ef\u7cfb\u7edf\u6027\u589e\u6b96\u81f3\u8fdc\u5904\u7684\u80bf\u7624\u90e8\u4f4d\uff084\uff09\u3002\u80bf\u7624\u7ec6\u80de\u6297\u539f\u5448\u9012\u7ed9 T \u7ec6\u80de\u5bfc\u81f4\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u6fc0\u6d3b\uff085\uff09\u3002\u80bf\u7624\u7ec6\u80de\u88c2\u89e3\u91ca\u653e\u80bf\u7624\u884d\u751f\u6297\u539f\uff08TDA\uff09\uff086\uff09\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.2.3 T-VEC\u7684\u7528\u836f\u6807\u51c6\u53ca\u64cd\u4f5c<\/p>\n<\/section>\n

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\u6839\u636e\u80bf\u7624\u5c3a\u5bf8\u786e\u5b9a\u6700\u5927\u6ce8\u5c04\u91cf\u3002T-VEC \u7684\u6ce8\u5c04\u91cf\u56e0\u75c5\u53d8\u5927\u5c0f\u800c\u5f02\uff1a\u80bf\u7624\u6700\u957f\u5c3a\u5bf8\u4e0d\u8d85\u8fc7 0.5 \u5398\u7c73\u4e3a 0.1 \u6beb\u5347\uff0c0.5 \u81f3 1.5 \u5398\u7c73\u4e3a 0.5 \u6beb\u5347\uff0c1.5 \u81f3 2.5 \u5398\u7c73\u4e3a 1 \u6beb\u5347\uff0c2.5 \u81f3 5 \u5398\u7c73\u4e3a 2 \u6beb\u5347\uff0c\u80bf\u7624\u6700\u957f\u5c3a\u5bf8\u8d85\u8fc7 5 \u5398\u7c73\u4e3a 4 \u6beb\u5347\u3002\u6bcf\u6b21\u6700\u5927\u6ce8\u5c04\u91cf\u4e3a 4 \u6beb\u5347\uff0c\u6ce8\u5c04\u91cf\u6839\u636e\u80bf\u7624\u6700\u957f\u5c3a\u5bf8\u7684\u4f53\u79ef\u8ba1\u7b97\u3002\u5f53\u5b58\u5728\u591a\u4e2a\u75c5\u7076\u65f6\uff0c\u5efa\u8bae\u9996\u5148\u6ce8\u5c04\u6700\u5927\u7684\u75c5\u7076\uff0c\u7136\u540e\u6ce8\u5c04\u5c0f\u4e00\u4e9b\u7684\u75c5\u7076\uff0c\u6700\u540e\u6ce8\u5c04\u65e0\u75c7\u72b6\u7684\u75c5\u7076\u3002\u6ce8\u5c04 T-VEC \u524d\uff0c\u5fc5\u987b\u7528\u9152\u7cbe\u68c9\u7403\u6e05\u6d01\u5f85\u6ce8\u5c04\u90e8\u4f4d\uff0c\u5e76\u8ba9\u5176\u98ce\u5e72\u3002\u5982\u679c\u75c5\u53d8\u8868\u9762\u65e0\u6cd5\u89e6\u53ca\uff0c\u5219\u5e94\u5728\u8d85\u58f0\u5f15\u5bfc\u4e0b\u5bf9\u8f83\u6df1\u7684\u76ae\u4e0b\u80bf\u7624\u8fdb\u884c\u6ce8\u5c04\u3002\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u5efa\u8bae\u4f7f\u7528 T-VEC \u6ce8\u5c04\u9488\u5355\u4e2a\u63d2\u5165\u90e8\u4f4d\uff0c\u4f46\u8f83\u5927\u7684\u80bf\u7624\u53ef\u80fd\u9700\u8981\u591a\u4e2a\u63d2\u5165\u90e8\u4f4d\u3002\u9664\u975e\u6ce8\u5c04\u90e8\u4f4d\u66fe\u6709\u8fc7\u75bc\u75db\u53f2\uff0c\u5426\u5219\u901a\u5e38\u4e0d\u9700\u8981\u5728\u6ce8\u5c04\u524d\u670d\u7528\u836f\u7269\u548c\u5c40\u90e8\u9ebb\u9189\u5242\u3002\u6cbb\u7597\u540e\uff0c\u5efa\u8bae\u5728\u6ce8\u5c04\u90e8\u4f4d\u6309\u538b 30 \u79d2\u3002\u6ce8\u5c04\u90e8\u4f4d\u5e94\u8986\u76d6\u7eb1\u5e03\u548c\u95ed\u585e\u6027\u6577\u6599\uff0c\u6bcf\u6b21\u6cbb\u7597\u540e\u5e94\u8986\u76d6\u4e00\u5468\u3002\u4e0e\u6cbb\u7597\u90e8\u4f4d\u63a5\u89e6\u7684\u6240\u6709\u6750\u6599\u90fd\u5e94\u91c7\u7528\u901a\u7528\u9884\u9632\u63aa\u65bd\u8fdb\u884c\u5904\u7406\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T-VEC \u662f\u4f5c\u4e3a\u751f\u7269\u5b89\u5168\u4e00\u7ea7\u5236\u5242\u5904\u7406\u7684\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u4e0d\u4f1a\u5bf9\u6b63\u5e38\u5065\u5eb7\u4eba\u9020\u6210\u6301\u7eed\u4f24\u5bb3\u3002\u5b83\u662f\u5728\u65e0\u83cc\u751f\u7269\u5b89\u5168\u67dc\u4e2d\u5236\u5907\u7684\u3002\u5b83\u6709\u4e24\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u5c0f\u74f6\uff1a\u6d53\u5ea6\u4e3a 106<\/sup> PFU\/ml \u7684\u9ec4\u7eff\u8272\u5c0f\u74f6\u548c\u6d53\u5ea6\u4e3a 108<\/sup> PFU\/ml \u7684\u84dd\u8272\u5c0f\u74f6\u3002\u8fd9\u4e9b\u5c0f\u74f6\u50a8\u5b58\u5728\u96f6\u4e0b 70 \u6444\u6c0f\u5ea6\u6216\u66f4\u4f4e\u7684\u6e29\u5ea6\u4e0b\uff0c\u5728\u5ba4\u6e29\u4e0b\u89e3\u51bb\uff0c\u76f4\u5230\u8f6c\u5316\u4e3a\u6db2\u6001\u4f9b\u4f7f\u7528\u3002\u89e3\u51bb\u540e\uff0c\u5c0f\u74f6\u53ef\u51b7\u85cf 12 \u5c0f\u65f6\uff08106 <\/sup>PFU\/ml \u6d53\u5ea6\uff09\u81f3 48 \u5c0f\u65f6\uff08108<\/sup> PFU\/ml \u6d53\u5ea6\uff09\u3002\u5c0f\u74f6\u89e3\u51bb\u540e\u4e0d\u80fd\u518d\u51b7\u51bb\u3002\u5728\u5904\u7406 T-VEC \u65f6\uff0c\u5fc5\u987b\u9075\u5b88\u4e2a\u4eba\u9632\u62a4\u88c5\u5907\u548c\u901a\u7528\u9884\u9632\u63aa\u65bd\u3002\u5982\u53d1\u751f\u610f\u5916\u63a5\u89e6\uff0c\u5e94\u5c06\u63a5\u89e6\u533a\u57df\u7528\u6c34\u6e05\u6d17 15 \u5206\u949f\u3002\u5982\u679c\u53d1\u751f\u6ea2\u51fa\uff0c\u5e94\u4f7f\u7528 10%\u6f02\u767d\u5242\u6eb6\u6db2\u548c\u5438\u6c34\u6750\u6599\u6e05\u6d17\u8868\u9762\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.2.4 \u4f7f\u7528T-VEC\u7684\u4e34\u5e8a\u524d\u7814\u7a76<\/p>\n<\/section>\n

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T-VEC\u5728\u9f20A20\u80bf\u7624\u6a21\u578b\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u5728\u53cc\u4fa7\u4fa7\u8179\u7cfb\u7edf\u4e2d\uff0c\u5c06\u8868\u8fbe\u548c\u4e0d\u8868\u8fbe GM-CSF \u57fa\u56e0\u7684 HSV-1 \u75c5\u6bd2\u682a\u6ce8\u5c04\u5230\u5355\u4fa7\u80bf\u7624\u4e2d\u3002\u8868\u8fbe\u548c\u4e0d\u8868\u8fbe GM-CSF \u7684 HSV-1 \u75c5\u6bd2\u682a\u90fd\u4f1a\u5bfc\u81f4\u80bf\u7624\u6d88\u9000\uff1b\u4f46\u53ea\u6709\u8868\u8fbe GM-CSF \u7684 HSV-1 \u624d\u4f1a\u5bfc\u81f4\u5bf9\u4fa7\u80bf\u7624\u6d88\u9000\u3002\u53ea\u6709\u7528\u8868\u8fbe GM-CSF \u7684 HSV-1 \u6cbb\u7597\u65f6\uff0c\u624d\u4f1a\u51fa\u73b0\u9488\u5bf9\u4eb2\u4ee3 A20 \u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027 T \u7ec6\u80de\uff0c\u8fd9\u8868\u660e\u8be5\u75c5\u6bd2\u682a\u4ea7\u751f\u4e86\u957f\u671f\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u4e3a\u8fdb\u4e00\u6b65\u6539\u9020 HSV-1 \u57fa\u56e0\u548c\u751f\u6210 T-VEC \u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T-VEC\u7b49\u7597\u6cd5\u88ab\u8ba4\u4e3a\u662f\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u7406\u60f3\u65b9\u6cd5\uff0c\u56e0\u4e3a\uff1a\uff081\uff09\u8f6c\u79fb\u7076\u7684\u5b58\u5728\u8868\u660e\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u540c\u65f6\u6269\u6563\u5230\u4e86\u771f\u76ae\u6dcb\u5df4\u7ba1\uff0c\u4f7f\u624b\u672f\u5207\u9664\u53d8\u5f97\u56f0\u96be\uff1b\uff082\uff09\u9ed1\u8272\u7d20\u7624\u7684\u8f6c\u79fb\u7076\u4f1a\u4f18\u5148\u6269\u6563\u5230\u76ae\u80a4\uff0c\u4f7f\u5176\u6210\u4e3a\u901a\u8fc7\u533a\u57df\u5185\u7597\u6cd5\u8fdb\u884c\u9776\u5411\u6cbb\u7597\u7684\u6700\u4f73\u9009\u62e9\u3002\u56e0\u6b64\uff0cT-VEC\u7597\u6cd5\u5728\u9ed1\u8272\u7d20\u7624\u65b9\u9762\u53d6\u5f97\u4e86\u5f88\u5927\u8fdb\u5c55\u3002\u4e3a\u4e86\u4e0e\u5185\u90e8\u7597\u6cd5\u4fdd\u6301\u4e00\u81f4\uff0c\u5361\u4ecb\u82d7\u3001GM-CSF\u3001IL-2\u3001PV-10 \u548c IFN-\u03b1 \u7b49\u836f\u7269\u5df2\u88ab\u4f7f\u7528\uff0c\u5e76\u5728\u6ce8\u5c04\u548c\u975e\u6ce8\u5c04\u75c5\u7076\u4e2d\u663e\u793a\u51fa\u53cd\u5e94\uff0c\u4f46\u53ea\u6709\u4e0d\u5230\u4e00\u534a\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u6cbb\u7597\u3002\u76ae\u80a4\u6bd2\u6027\u548c\u7f3a\u4e4f\u7cfb\u7edf\u6027\u83b7\u76ca\u9650\u5236\u4e86\u8fd9\u4e9b\u836f\u7269\u7684\u4f7f\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76\u8868\u660e\uff0c\u6ce8\u5c04 T-VEC \u53ef\u589e\u52a0\u5c40\u90e8\u548c\u5168\u8eab MART-1 \u7279\u5f02\u6027 CD8+<\/sup> \u6548\u5e94 T \u7ec6\u80de\uff0c\u540c\u65f6\u51cf\u5c11 CD4+<\/sup> Foxp3+<\/sup> \u8c03\u8282 T \u7ec6\u80de\u548c\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de (MDSC)\u3002\u4e0e\u672a\u6ce8\u5c04\u90e8\u4f4d\u76f8\u6bd4\uff0c\u6ce8\u5c04\u90e8\u4f4d\u7684\u8c03\u8282\u6027T\u7ec6\u80de\u6bd4\u4f8b\u8f83\u4f4e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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24.2.5 \u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/p>\n<\/section>\n

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\u5728I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5bf930\u4f8b\u60a3\u8005\uff08\u5305\u62ec\u665a\u671f\u4e73\u817a\u764c\uff0c\u5934\u9888\u764c\uff0c\u7ed3\u80a0\u76f4\u80a0\u764c\u548c\u9ed1\u8272\u7d20\u7624\uff09\u7684\u76ae\u80a4\uff0c\u76ae\u4e0b\u6216\u6d45\u8868\u6dcb\u5df4\u7ed3\u90e8\u4f4d\u7684T-VEC\u8fdb\u884c\u4e86\u5b89\u5168\u6027\uff0c\u6700\u4f73\u5242\u91cf\u548c\u65f6\u95f4\u8868\u8bc4\u4f30\u3002\u572819\u4e2a\u53ef\u8bc4\u4f30\u7684\u7ec4\u7ec7\u5b66\u6807\u672c\u4e2d\uff0c73%\u7684\u6ce8\u5c04\u90e8\u4f4d\u6d3b\u7ec4\u7ec7\u68c0\u67e5\u53d1\u73b0\u708e\u75c7\u548c\u574f\u6b7b\u3002\u574f\u6b7b\u90e8\u4f4d\u7684 HSV \u86cb\u767d\u67d3\u8272\u8f83\u5f3a\u3002\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u975e\u80bf\u7624\u7ec6\u80de\u65e0\u574f\u6b7b\u8ff9\u8c61\uff0c\u8bc1\u660e\u4e86 T-VEC \u7684\u80bf\u7624\u7279\u5f02\u6027\u3002\u8be5\u7814\u7a76\u5f97\u51fa\u7684\u6700\u4f73\u5242\u91cf\u548c\u7597\u7a0b\u4e3a\u521d\u59cb\u5242\u91cf 106<\/sup> PFU\/ml\uff0c3 \u5468\u540e\u5242\u91cf\u4e3a 108<\/sup> PFU\/ml\uff0c\u6bcf 2 \u5468\u91cd\u590d\u4e00\u6b21\uff0c\u76f4\u81f3\u51fa\u73b0\u4e34\u5e8a\u53cd\u5e94\u3001\u6bd2\u6027\u6216\u75be\u75c5\u8fdb\u5c55\u3002HSV\u8840\u6e05\u9634\u6027\u548c\u8840\u6e05\u9633\u6027\u60a3\u8005\u7684\u4e34\u5e8a\u6d3b\u6027\u76f8\u4f3c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T-VEC \u5728 I \u671f\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u751f\u7269\u6d3b\u6027\u540e\uff0c\u53c8\u5728 III \u671f\u548c IV \u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u5f00\u5c55\u4e86 II \u671f\u7814\u7a76\u3002\u6839\u636e RECIST \u6807\u51c6\u8bc4\u4f30\uff0c26% \u7684\u60a3\u8005\u6709\u4e86\u5e94\u7b54\uff0c\u5176\u4e2d 8 \u540d\u60a3\u8005\u83b7\u5f97\u4e86\u5b8c\u5168\u5e94\u7b54\u300292%\u7684\u60a3\u8005\u83b7\u5f97\u4e867\u4e2a\u6708\u523031\u4e2a\u6708\u4e0d\u7b49\u7684\u6301\u4e45\u5e94\u7b54\u3002\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\u7684 1 \u5e74\u5b58\u6d3b\u7387\u4e3a 58%\uff0c\u800c\u6709\u521d\u6b65\u5ba2\u89c2\u53cd\u5e94\u7684\u60a3\u8005\u7684\u5b58\u6d3b\u7387\u4e3a 93% \u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7f8e\u56fd\u8fdb\u884c\u7684\u4e00\u9879Ib\u671f\u7814\u7a76\uff08NCT01740297\uff09\u4e2d\uff0c19\u540d\u60a3\u8005\u63a5\u53d7\u4e86T-VEC\u4e0e\u4f0a\u5339\u5355\u6297\u8054\u5408\u6cbb\u7597\u3002T-VEC\u7684\u5242\u91cf\u4e3a\u7b2c1\u5929106<\/sup> PFU\/ml\uff0c3\u5468\u540e\u7b2c\u4e8c\u6b21\u5242\u91cf\u4e3a108<\/sup> PFU\/ml\uff0c\u6bcf2\u5468\u91cd\u590d\u4e00\u6b21\u3002\u4f0a\u5339\u5355\u6297\u7684\u5242\u91cf\u4e3a3\u6beb\u514b\/\u5343\u514b\uff0c\u4ece\u7b2c6\u5468\u7684\u7b2c1\u5929\u5f00\u59cb\uff0c\u6bcf3\u5468\u4e00\u6b21\uff0c\u51714\u6b21\u3002<\/p>\n

\u96645\u540d\u60a3\u8005\u62a5\u544a\u22653\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5916\uff0c\u8be5\u7597\u6cd5\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u6076\u5fc3\u662f\u5e38\u89c1\u7684 3 \u7ea7\u4e0d\u826f\u4e8b\u4ef6\u3002\u5176\u4ed6\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u53d1\u70ed\u3001\u75b2\u52b3\u3001\u6d41\u611f\u6837\u75c7\u72b6\u3001\u8131\u6c34\u3001\u8179\u6cfb\u548c\u5455\u5410\u3002<\/p>\n

\u4f7f\u7528\u514d\u75ab\u76f8\u5173\u53cd\u5e94\u6307\u6807\uff08irRC\uff09\u8bc4\u4f30\u7684\u603b\u53cd\u5e94\u7387\u4e3a56%\uff0c\u5176\u4e2d4\u4f8b\uff0833%\uff09\u5b8c\u5168\u53cd\u5e94\uff0c5\u4f8b\u90e8\u5206\u53cd\u5e94\u3002\u8fd9\u4e00\u603b\u4f53\u53cd\u5e94\u7387\u4e0e\u4f7f\u7528\u4f0a\u5339\u5355\u6297\u548c\u5c3c\u592b\u5355\u6297\u768456%\u76f8\u5f53\uff0c\u53ea\u662f55%\u7684\u53c2\u4e0e\u8005\u51fa\u73b0\u4e863\/4\u7ea7AE\u3002\u6301\u4e45\u5e94\u7b54\u7387\uff08\u5e94\u7b54\u6301\u7eed\u65f6\u95f4\u22656\u4e2a\u6708\uff09\u4e3a44%\u300212\u4e2a\u6708\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a50%\uff0c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e3a72%\u3002\u6d3b\u5316\u7684 CD8+ T \u7ec6\u80de\uff08CD3+<\/sup>\u3001CD4–<\/sup>\u3001HLA-DR+<\/sup>\uff09\u5728\u6cbb\u7597\u540e\u6bd4\u57fa\u7ebf\u589e\u52a0\u4e86 1.5 \u500d\uff0c\u5e76\u4e0e\u5e94\u7b54\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e0e\u6b64\u7c7b\u4f3c\uff0c\u4e00\u9879Ib\/III\u671f\u7814\u7a76\uff08NCT2263508\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u8be5\u7814\u7a76\u7814\u7a76\u4e86T-VEC\u4e0e\u6d3e\u59c6\u5355\u6297\u5728\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u3001\u65e0\u6cd5\u5207\u9664\u7684III\/IV\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u7684\u8054\u5408\u5e94\u7528\u3002\u6839\u636e\u76ee\u524d\u516c\u5e03\u7684Ib\u671f\u7814\u7a76\u7ed3\u679c\uff0c\u4f7f\u7528irRC\u8bc4\u4f30\u7684\u786e\u8bca\u603b\u53cd\u5e94\u7387\u4e3a57.1%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a23.8%\u3002\u53c2\u4e0e\u8005\u5728\u7b2c1\u5929\u63a5\u53d7\u5242\u91cf\u4e3a106<\/sup> PFU\/ml\u7684T-VEC\u6cbb\u7597\uff0c\u7b2c22\u5929\u63a5\u53d7\u5242\u91cf\u4e3a108<\/sup> PFU\/ml\u7684T-VEC\u6cbb\u7597\uff0c\u6b64\u540e\u6bcf2\u5468\u63a5\u53d7\u4e00\u6b21\u6cbb\u7597\uff0c\u800c\u6d3e\u59c6\u5355\u6297\u7684\u9759\u8109\u6ce8\u5c04\u5242\u91cf\u4e3a200\u6beb\u514b\uff0c\u7b2c36\u5929\u63a5\u53d7\u6cbb\u7597\uff0c\u6b64\u540e\u6bcf2\u5468\u63a5\u53d7\u4e00\u6b21\u6cbb\u7597\u300233%\u7684\u60a3\u8005\u51fa\u73b0\u4e863\/4\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u6ca1\u6709\u51fa\u73b05\u7ea7\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u9879\u7814\u7a76 T-VEC \u5728\u665a\u671f\u80f0\u817a\u764c\u60a3\u8005\u4e2d\u5b89\u5168\u6027\u7684 I \u671f\u8bd5\u9a8c\u8bc1\u660e\uff0cT-VEC \u53ef\u901a\u8fc7\u5185\u7aa5\u955c\u3001\u8d85\u58f0\u5f15\u5bfc\u4e0b\u7684\u7ec6\u9488\u6ce8\u5c04 (EUSFNI) \u5b89\u5168\u5730\u76f4\u63a5\u7528\u4e8e\u5185\u810f\u75c5\u7076\u3002\u6839\u636e\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u60a3\u8005\u5c06\u5148\u63a5\u53d7104<\/sup> PFU\/ml\u81f3106 <\/sup>PFU\/ml\u4e0d\u7b49\u7684\u9996\u5242T-VEC\uff0c\u7136\u540e\u6bcf\u4e24\u5468\u518d\u63a5\u53d7\u4e24\u5242107<\/sup>-108<\/sup> PFU\/ml\u4e0d\u7b49\u7684T-VEC\uff0c\u6240\u6709\u5242\u91cf\u5747\u5728\u5185\u955c\u4e0b\u6ce8\u5c04\u3002\u8be5\u7814\u7a76\u8ba1\u5212\u5206\u56db\u7ec4\u8fdb\u884c\uff0c\u4f46\u7531\u4e8e\u5b89\u5168\u6027\u4ee5\u5916\u7684\u539f\u56e0\uff0c\u7814\u7a76\u5728\u7b2c\u56db\u7ec4\u5165\u7ec4\u4e4b\u524d\u5c31\u505c\u6b62\u4e86\u3002\u7b2c 3 \u7ec4\u7684 4 \u4eba\u4e2d\u6709 2 \u4eba\u7684\u80bf\u7624\u7f29\u5c0f\u8d85\u8fc7 30%\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u8179\u6c34\u3001\u8131\u6c34\u3001\u8d2b\u8840\u3001\u8179\u75db\u3001\u4fbf\u79d8\u3001\u6076\u5fc3\u548c\u5455\u5410\u3002\u867d\u7136\u51fa\u73b0\u4e86\u4e24\u4f8b\u4e94\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u4f46\u8fd9\u4e9b\u4e0d\u826f\u53cd\u5e94\u5e76\u975e\u7531\u7814\u7a76\u836f\u7269\u5f15\u8d77\u3002\u6709\u8da3\u7684\u662f\uff0c59% \u7684\u53c2\u4e0e\u8005\u5728\u63a5\u53d7\u8ba1\u5212\u7684\u6cbb\u7597\u524d\u4e2d\u65ad\u4e86\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u4e00\u9879 I\/II \u671f\u7814\u7a76\u4e2d\uff0cT-VEC \u8fd8\u4e0e\u653e\u7597\u548c\u987a\u94c2\u8054\u5408\u7528\u4e8e\u672a\u7ecf\u6cbb\u7597\u7684 III\/IV \u671f\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u60a3\u8005\u3002\u53c2\u4e0e\u8005\u5728\u7b2c 1\u300122 \u548c 43 \u5929\u63a5\u53d7 70 Gy \u5206 35 \u6b21\u7684\u5316\u653e\u7597\uff0c\u987a\u94c2\u5242\u91cf\u4e3a 100 mg\/m2<\/sup>\u3002T-VEC\u7684\u521d\u59cb\u5242\u91cf\u4e3a106<\/sup> PFU\/ml\uff0c\u968f\u540e\u5728\u7ec4\u522b1\u30012\u548c3\u4e2d\u5206\u522b\u8ffd\u52a0\u4e24\u4e2a\u5242\u91cf106<\/sup> PFU\/ml\u3001107<\/sup> PFU\/ml\u6216108<\/sup> PFU\/ml\u3002\u8be5\u6cbb\u7597\u65b9\u6848\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u672a\u62a5\u544a\u51fa\u73b0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u6240\u6709\u60a3\u8005\u5747\u5728 6-10 \u5468\u540e\u63a5\u53d7\u9888\u90e8\u5207\u9664\u672f\u3002RECIST\u8bc4\u4f30\u7684\u53cd\u5e94\u7387\u4e3a82%\uff084\u4f8b\u5b8c\u5168\u53cd\u5e94\uff0c10\u4f8b\u90e8\u5206\u53cd\u5e94\uff09\uff0c93%\u7684\u60a3\u8005\u5728\u9888\u90e8\u5207\u9664\u672f\u65f6\u51fa\u73b0\u75c5\u7406\u5b8c\u5168\u53cd\u5e94\u300229\u4e2a\u6708\u540e\uff0c\u75be\u75c5\u7279\u5f02\u6027\u751f\u5b58\u7387\u4e3a82%\uff0c\u65e0\u590d\u53d1\u751f\u5b58\u7387\u4e3a76%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5176\u4ed6\u9009\u5b9a\u7684\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u5217\u4e8eTable 24.1<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 24.1 <\/span>\u6eb6\u7624\u75c5\u6bd2\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u603b\u7ed3<\/span><\/p>\n

PCR \u75c5\u7406\u5b8c\u5168\u5e94\u7b54\u3001ORR \u603b\u5e94\u7b54\u7387\u3001OS \u603b\u751f\u5b58\u7387\u3001RFS \u65e0\u590d\u53d1\u751f\u5b58\u7387\u3001PFS \u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u3001TTP \u8fdb\u5c55\u65f6\u95f4\u3001DCR \u75be\u75c5\u63a7\u5236\u7387\u3001AE \u4e0d\u826f\u4e8b\u4ef6\u3001NCI \u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u3001HCC \u809d\u7ec6\u80de\u764c\u3001TIL \u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u3001RP2D \u63a8\u8350II\u671f\u5242\u91cf\uff0cPS \u6027\u80fd\u72b6\u6001\u3001QoL \u751f\u6d3b\u8d28\u91cf\u3001DLT \u5242\u91cf\u9650\u5236\u6bd2\u6027\u30015FU 5-\u6c1f\u5c3f\u5627\u5576\u3001FOLFIRI 5FU+\u4f0a\u7acb\u66ff\u5eb7+\u4e9a\u53f6\u9178<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Rutika Mehta and Igor Puzanov<\/span><\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u674e\u5b89\u742a \u6f58\u541b\u541b<\/span><\/span><\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u90ed\u5b50<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764 \u80e1\u73ca<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
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\n
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<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

24.1 \u80cc\u666f\u4ecb\u7ecd \u514d\u75ab\u6cbb\u7597\u5df2\u6210\u4e3a\u9ed1\u8272\u7d20\u7624\u3001\u80ba\u764c\u3001\u5934\u9888\u90e8\u80bf\u7624\u7b49\u591a\u79cd\u665a\u671f\u764c\u75c7\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u6dcb\u5df4\u7ec6\u80de\u4e30\u5bcc\u7684\u80bf\u7624\u5fae\u73af\u5883\u662f\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u9884\u6d4b\u56e0\u7d20\u3002 \u5c3d\u7ba1\u4ece\u7406\u8bba\u4e0a\u8bb2\uff0c\u8fd9\u4e9b\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u5e94…<\/p>\n","protected":false},"author":1,"featured_media":5219,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5226"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5226"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5226\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5219"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5226"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}