{"id":5435,"date":"2024-03-24T07:09:32","date_gmt":"2024-03-23T23:09:32","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/03\/24\/cell-metab%ef%bc%9a%e8%82%bf%e7%98%a4%e5%88%86%e6%b3%8c%e7%9a%84fgf21%e9%80%9a%e8%bf%87%e9%87%8d%e5%a1%91cd8t%e7%bb%86%e8%83%9e%e7%9a%84%e8%83%86%e5%9b%ba%e9%86%87%e4%bb%a3%e8%b0%a2%e5%8f%91%e6%8c%a5\/"},"modified":"2024-03-24T07:09:32","modified_gmt":"2024-03-23T23:09:32","slug":"cell-metab%ef%bc%9a%e8%82%bf%e7%98%a4%e5%88%86%e6%b3%8c%e7%9a%84fgf21%e9%80%9a%e8%bf%87%e9%87%8d%e5%a1%91cd8t%e7%bb%86%e8%83%9e%e7%9a%84%e8%83%86%e5%9b%ba%e9%86%87%e4%bb%a3%e8%b0%a2%e5%8f%91%e6%8c%a5","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/03\/24\/cell-metab%ef%bc%9a%e8%82%bf%e7%98%a4%e5%88%86%e6%b3%8c%e7%9a%84fgf21%e9%80%9a%e8%bf%87%e9%87%8d%e5%a1%91cd8t%e7%bb%86%e8%83%9e%e7%9a%84%e8%83%86%e5%9b%ba%e9%86%87%e4%bb%a3%e8%b0%a2%e5%8f%91%e6%8c%a5\/","title":{"rendered":"Cell Metab\uff1a\u80bf\u7624\u5206\u6ccc\u7684FGF21\u901a\u8fc7\u91cd\u5851CD8+T\u7ec6\u80de\u7684\u80c6\u56fa\u9187\u4ee3\u8c22\u53d1\u6325\u514d\u75ab\u6291\u5236\u4f5c\u7528"},"content":{"rendered":"
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<\/section>\n<\/section>\n
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\u6742\u5fd7\u540d\u79f0<\/strong>\uff1aCell Metab.<\/span><\/p>\n

\u53d1\u8868\u65e5\u671f<\/strong>\uff1a2024.01.23<\/p>\n

DOI<\/strong>\uff1a10.1016\/j.cmet.2024.01.005.<\/p>\n

PubMed<\/strong>\uff1ahttps:\/\/pubmed.ncbi.nlm.nih.gov\/38309268\/<\/p>\n

\u5f71\u54cd\u56e0\u5b50<\/strong>\uff1a29.0<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n<\/section>\n

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\u80bf\u7624\u91c7\u7528\u591a\u79cd\u7b56\u7565\u6765\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u653b\u51fb\u3002\u63ed\u793a\u80bf\u7624\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u7684\u673a\u5236\u6709\u52a9\u4e8e\u514d\u75ab\u7597\u6cd5\u7684\u53d1\u5c55\u3002\u6211\u4eec\u5df2\u7ecf\u786e\u5b9a\u80bf\u7624\u5206\u6ccc\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b5021\uff08FGF21\uff09\u662f\u4e00\u4e2a\u5173\u952e\u7684\u514d\u75ab\u6291\u5236\u5242\u3002\u5728\u591a\u79cd\u7c7b\u578b\u7684\u80bf\u7624\u4e2d\uff0cFGF21\u8868\u8fbe\u4e0a\u8c03\uff0c\u5e76\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\u3002\u80bf\u7624\u5206\u6ccc\u7684FGF21\u663e\u8457\u6270\u4e71\u6297\u80bf\u7624\u514d\u75ab\uff0c\u901a\u8fc7\u91cd\u5851CD8+T\u7ec6\u80de\u7684\u80c6\u56fa\u9187\u4ee3\u8c22\u3002\u5728\u673a\u5236\u4e0a\uff0cFGF21\u7ef4\u6301\u6fc0\u6d3b\u7684CD8+T\u7ec6\u80de\u4e2dAKT-mTORC1-\u56fa\u9187\u8c03\u8282\u5143\u4ef6\u7ed3\u5408\u86cb\u767d1\uff08SREBP1\uff09\u4fe1\u53f7\u8f74\u7684\u9ad8\u6d3b\u6027\u72b6\u6001\uff0c\u5bfc\u81f4\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210\u589e\u52a0\u548cT\u7ec6\u80de\u8017\u7aed\u3002\u901a\u8fc7\u4f7f\u7528\u4e2d\u548c\u6297\u4f53\u964d\u4f4eFGF21\u8868\u8fbe\u6216\u963b\u65adFGF21\u53ef\u4ee5\u4f7fAKT-mTORC1\u4fe1\u53f7\u6b63\u5e38\u5316\uff0c\u5e76\u51cf\u5c11CD8+T\u7ec6\u80de\u4e2d\u8fc7\u91cf\u7684\u80c6\u56fa\u9187\u79ef\u7d2f\uff0c\u4ece\u800c\u6062\u590dCD8+T\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u529f\u80fd\uff0c\u5e76\u5f3a\u6709\u529b\u5730\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u6211\u4eec\u7684\u53d1\u73b0\u63ed\u793a\u4e86FGF21\u4f5c\u4e3a\u4e00\u4e2a\u201c\u5206\u6ccc\u578b\u514d\u75ab\u68c0\u67e5\u70b9\u201d\uff0c\u963b\u788d\u6297\u80bf\u7624\u514d\u75ab\uff0c\u8868\u660e\u6291\u5236FGF21\u53ef\u80fd\u662f\u589e\u5f3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6548\u679c\u7684\u4e00\u4e2a\u6709\u4ef7\u503c\u7684\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u521b\u65b0\u6027\u53ca\u7814\u7a76\u610f\u4e49<\/strong><\/p>\n<\/section>\n

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\u8fd9\u7bc7\u6587\u7ae0\u7684\u6838\u5fc3\u521b\u65b0\u6027\u5728\u4e8e\u8bc6\u522b\u4e86\u80bf\u7624\u5206\u6ccc\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b5021\uff08FGF21\uff09\u4f5c\u4e3a\u4e00\u4e2a\u5173\u952e\u7684\u514d\u75ab\u6291\u5236\u56e0\u5b50\u3002\u7814\u7a76\u53d1\u73b0\uff0cFGF21\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u8868\u8fbe\u4e0a\u8c03\uff0c\u5e76\u901a\u8fc7\u91cd\u5851CD8+T\u7ec6\u80de\u7684\u80c6\u56fa\u9187\u4ee3\u8c22\u663e\u8457\u5e72\u6270\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u5177\u4f53\u673a\u5236\u662fFGF21\u7ef4\u6301CD8+T\u7ec6\u80de\u5185AKT-mTORC1-SREBP1\u4fe1\u53f7\u8f74\u7684\u9ad8\u6d3b\u6027\u72b6\u6001\uff0c\u5bfc\u81f4\u80c6\u56fa\u9187\u5408\u6210\u589e\u52a0\u548cT\u7ec6\u80de\u529f\u80fd\u8017\u7aed\u3002\u901a\u8fc7\u964d\u4f4eFGF21\u8868\u8fbe\u6216\u4f7f\u7528\u4e2d\u548c\u6297\u4f53\u963b\u65ad\u5176\u4f5c\u7528\uff0c\u53ef\u4ee5\u6062\u590dCD8+T\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u529f\u80fd\uff0c\u6709\u6548\u6291\u5236\u80bf\u7624\u751f\u957f\u3002<\/p>\n

\u7814\u7a76\u610f\u4e49\u5728\u4e8e\u63ed\u793a\u4e86FGF21\u4f5c\u4e3a\u4e00\u4e2a\u201c\u5206\u6ccc\u578b\u514d\u75ab\u68c0\u67e5\u70b9\u201d\uff0c\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u9776\u70b9\u3002\u901a\u8fc7\u6291\u5236FGF21\uff0c\u53ef\u80fd\u4e3a\u589e\u5f3a\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u6548\u679c\u63d0\u4f9b\u4e86\u4e00\u6761\u65b0\u7684\u7b56\u7565\u8def\u5f84\uff0c\u4e3a\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u548c\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6570\u636e\u56fe<\/strong><\/p>\n<\/section>\n

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\u56fe 1\uff1aFGF21\u8868\u8fbe\u4e0e\u80bf\u7624\u8fdb\u5c55\u7684\u4e0d\u826f\u9884\u540e\u76f8\u5173<\/strong><\/p>\n

(A) \u4f7f\u7528\u5bf9\u7167\u57f9\u517b\u57fa\uff08CM\uff09\u6216\u80bf\u7624\u6761\u4ef6\u57f9\u517b\u57fa\uff08TCM\uff09\u5904\u7406\u7684CD8+ T\u7ec6\u80de\uff0c\u5728\u7ecf\u8fc7\u6297CD3\/CD28\u6fc0\u6d3b72\u5c0f\u65f6\u540e\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\uff08FACS\uff09\u5206\u6790IFNg+\u548cgranzyme B+\u7684\u8868\u8fbe\u60c5\u51b5\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(B) \u901a\u8fc7\u7ec6\u80de\u56e0\u5b50\u82af\u7247\u9635\u5217\u5206\u6790\u4e0a\u8ff0\u6307\u5b9a\u80bf\u7624\u7ec6\u80de\u7cfb\u7684CM\u548cTCM\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\u4e30\u5ea6\u7684\u70ed\u56fe\u3002<\/p>\n

(C) \u901a\u8fc7\u9176\u8054\u514d\u75ab\u5438\u9644\u6d4b\u5b9a\uff08ELISA\uff09\u5206\u6790\u4e0a\u8ff0\u6307\u5b9a\u80bf\u7624\u7ec6\u80de\u7cfb\u7684CM\u548cTCM\u4e2dFGF21\u86cb\u767d\u6c34\u5e73\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(D) \u901a\u8fc7ELISA\u5206\u6790\u6b63\u5e38\u5c0f\u9f20\u4e0e\u643a\u5e26\u80bf\u7624\u7684\u5c0f\u9f20\u8840\u6e05\u4e2d\u7684FGF21\u86cb\u767d\u6c34\u5e73\uff08n = 6\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(E) \u901a\u8fc7ELISA\u5206\u6790\u7ed3\u80a0\u764c\u60a3\u8005\u5207\u9664\u7684\u80bf\u7624\u7ec4\u7ec7\u53ca\u76f8\u90bb\u6b63\u5e38\u7ec4\u7ec7\u7684\u7ec4\u7ec7\u88c2\u89e3\u6db2\u4e2dFGF21\u86cb\u767d\u6c34\u5e73\uff08n = 29\u540d\u60a3\u8005\uff09\u3002<\/p>\n

(F) \u5206\u6790\u7ed3\u80a0\u764c\u60a3\u8005\u4f53\u5185FGF21\u86cb\u767d\u6c34\u5e73\u4e0e\u80bf\u7624\u4f53\u79ef\u4e4b\u95f4\u7684\u76f8\u5173\u6027\uff08n = 28\u540d\u60a3\u8005\uff09\u3002\u8fdb\u884c\u4e86\u7ebf\u6027\u56de\u5f52\u5206\u6790\u3002<\/p>\n

(G) \u901a\u8fc7Kaplan-Meier\u751f\u5b58\u5206\u6790\uff0c\u6bd4\u8f83\u88ab\u5206\u7c7b\u4e3aFGF21\u9ad8\u8868\u8fbe\uff08n = 30\u540d\u60a3\u8005\uff09\u548cFGF21\u4f4e\u8868\u8fbe\uff08n = 31\u540d\u60a3\u8005\uff09\u7684\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u751f\u5b58\u60c5\u51b5\uff0c\u4f7f\u7528Log-rank\u68c0\u9a8c\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u3002*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001\uff0c\u901a\u8fc7\u5b66\u751ft\u68c0\u9a8c\u8fdb\u884c\u6bd4\u8f83\uff08A \u548c C\u2013E\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe 2\uff1a\u80bf\u7624\u7ec6\u80de\u4e2dFGF21\u7684\u7f3a\u5931\u901a\u8fc7\u589e\u5f3a\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u6765\u6291\u5236\u80bf\u7624\u751f\u957f<\/strong><\/p>\n

(A) \u5728\u63a5\u79cd\u4e86\u5bf9\u7167\uff08shNC\uff09\u6216shFgf21\u80bf\u7624\u7ec6\u80de\u7684\u91ce\u751f\u578b\uff08WT\uff09\u5c0f\u9f20\u4e2d\uff0cMC38\u3001E0771\u548cB16-OVA\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff08n = 5\u20138\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(B) \u5bf9(A)\u4e2d\u643a\u5e26\u80bf\u7624\u7684\u5c0f\u9f20\u8840\u6e05\u8fdb\u884c\u7684FGF21\u6c34\u5e73\u7684ELISA\u5206\u6790\uff08n = 5\u20138\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(C) \u5728\u63a5\u79cd\u4e86shNC\u6216shFgf21\u80bf\u7624\u7ec6\u80de\u7684Rag2-\/-<\/sup>\u5c0f\u9f20\u4e2d\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(D\u2013F) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\uff08FACS\uff09\u5206\u6790shNC\u548cshFgf21\u80bf\u7624\u4e2d\u7684\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u6bd4\u4f8b\uff08D\uff09\u3001CD8+<\/sup> T\u7ec6\u80de\u51cb\u4ea1\u60c5\u51b5\uff08E\uff09\u4ee5\u53caCD8+ <\/sup>T\u7ec6\u80de\u4e2dgranzyme B+<\/sup>\u548cIFNg+<\/sup>\u7684\u8868\u8fbe\uff08F\uff09\uff08n = 4\u20136\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(G) \u5bf9OT-1 CTLs\u7ec6\u80de\u8fc7\u7ee7\u6027\u8f6c\u79fb\u7684\u793a\u610f\u56fe\u3002<\/p>\n

(H) \u5728\u63a5\u53d7OT-1 CTLs\u7ec6\u80de\u8fc7\u7ee7\u6027\u8f6c\u79fb\u7684shNC\u548cshFgf21\u80bf\u7624\u643a\u5e26\u7684Rag2-\/-<\/sup>\u5c0f\u9f20\u4e2d\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(I) \u5728\u8fdb\u884cOT-1 CTLs\u7ec6\u80de\u8fc7\u7ee7\u6027\u8f6c\u79fb\u540e\uff0c\u901a\u8fc7FACS\u5206\u6790CD8+ <\/sup>T\u7ec6\u80de\u4e2dgranzyme B+<\/sup>\u548cIFNg+<\/sup>\u7684\u8868\u8fbe\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(J) \u5728CD8+ <\/sup>T\u7ec6\u80de\u8017\u7aed\u540e\uff0cshNC\u6216shFgf21\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u3002*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001\uff0cns\u8868\u793a\u65e0\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u901a\u8fc7\u5b66\u751ft\u68c0\u9a8c\uff08B\u548cE\uff09\u4ee5\u53ca\u53cc\u5411\u65b9\u5dee\u5206\u6790\uff08A, C, D, F, H, I, \u548c J\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe 3\uff1a\u80bf\u7624\u5206\u6ccc\u7684FGF21\u9650\u5236CD8+ <\/sup>T\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528<\/strong><\/p>\n

(A) shNC\u548cshFgf21\u80bf\u7624\u7ec6\u80de\u5f62\u6210\u7684MC38\u80bf\u7624\u4e2d\u5206\u9009\u51fa\u7684\u80bf\u7624\u7ec6\u80de\u548cT\u7ec6\u80de\u7684RNA\u6d4b\u5e8f\u793a\u610f\u56fe\u3002<\/p>\n

(B) \u5982(A)\u6240\u8ff0\uff0c\u5bf9\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u8fdb\u884c\u7684Go\u5bcc\u96c6\u5206\u6790\u3002<\/p>\n

(C) \u5982(A)\u6240\u8ff0\uff0cTILs\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\uff08DEGs\uff09\u7684\u706b\u5c71\u56fe\u3002<\/p>\n

(D) \u6765\u81eaTCGA\u6570\u636e\u5e93\uff0c\u6bd4\u8f83\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2dFGF21\u9ad8\u8868\u8fbe\u7ec4\u4e0e\u4f4e\u8868\u8fbe\u7ec4\u7684CTL\u7279\u5f81\u7684\u7bb1\u7ebf\u56fe\u3002<\/p>\n

(E) \u7ecf\u8fc712\u5c0f\u65f6\u5171\u57f9\u517b\u540e\uff0cOT-1 CD8+ <\/sup>T\u7ec6\u80de\u5bf9\u8868\u8fbeshNC\u6216shFgf21\u7684OVA\u80bf\u7624\u7ec6\u80de\u7684granzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(F) \u5206\u6790OT-1 CTLs\u7ec6\u80de\u6bd2\u6027\u7684\u793a\u610f\u56fe\u3002<\/p>\n

(G) OT-1 CTLs\u5b75\u80b2\u540e\uff0c\u8868\u8fbeshNC\u6216shFgf21\u7684OVA\u80bf\u7624\u7ec6\u80de\u7684\u6eb6\u89e3\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(H) \u7ecf\u8fc7rFGF21\u5904\u7406\uff0c\u6216\u52a0\u4e0a\u514d\u75ab\u7403\u86cb\u767dG\uff08IgG\uff09\u5bf9\u7167\u6216\u6297FGF21\u5904\u7406\u7684\uff0c\u7ecf\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u7684granzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(I) \u9884\u5904\u7406\u4e86IgG\u5bf9\u7167\u6216\u6297FGF21\u7684\uff0c\u8868\u8fbeOVA\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u968f\u540e\u4e0eOT-1 CTLs\u5171\u57f9\u517b\u7684\u7ec6\u80de\u6eb6\u89e3\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u3002*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns\u8868\u793a\u65e0\u663e\u8457\u6027\uff0c\u901a\u8fc7\u5b66\u751ft\u68c0\u9a8c\uff08D\u548cI\uff09\u548c\u53cc\u5411\u65b9\u5dee\u5206\u6790\uff08E, G, \u548c H\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\u56fe 4\uff1aFGF21\u4fc3\u8fdb\u80c6\u56fa\u9187\u4ea7\u751f\uff0c\u7834\u574fCD8+ <\/sup>T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027<\/strong><\/p>\n

(A) \u5229\u7528\u57fa\u56e0\u96c6\u5bcc\u96c6\u5206\u6790\uff08GSEA\uff09\u5206\u6790\uff0c\u7814\u7a76\u6765\u6e90\u4e8eshNC\u548cshFgf21 MC38\u80bf\u7624\u4e2d\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u7684\u80c6\u56fa\u9187\u4ee3\u8c22\u57fa\u56e0\u7279\u5f81\u3002<\/p>\n

(B \u548c C) Filipin III\u67d3\u8272\u663e\u793a\u80c6\u56fa\u9187\u542b\u91cf\uff08B\uff09\u548c\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u5728\u5bf9\u7167\u57f9\u517b\u57fa\uff08CM\uff09\u6216\u80bf\u7624\u6761\u4ef6\u57f9\u517b\u57fa\uff08TCM\uff09\u4e2d\u57f9\u517b72\u5c0f\u65f6\u540e\uff0c\u80c6\u56fa\u9187\u76f8\u5173\u57fa\u56e0\u7684\u5b9e\u65f6PCR\u5206\u6790\uff08C\uff09\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(D \u548c E) Filipin III\u67d3\u8272\u663e\u793a\u80c6\u56fa\u9187\u542b\u91cf\uff08D\uff09\u548c\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u5728\u7ecfrFGF21\u5904\u7406\uff0c\u6216\u52a0\u4e0aIgG\u5bf9\u7167\u6216\u6297FGF21\u5904\u740672\u5c0f\u65f6\u540e\uff0c\u80c6\u56fa\u9187\u76f8\u5173\u57fa\u56e0\u7684\u5b9e\u65f6PCR\u5206\u6790\uff08E\uff09\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(F) \u4eceshNC\u6216shFgf21 MC38-OVA\u80bf\u7624\u643a\u5e26\u7684Rag2-\/-<\/sup>\u5c0f\u9f20\u4e2d\u8f6c\u79fb\u7684OT-1 T\u7ec6\u80de\u7684Filipin III\u67d3\u8272\u663e\u793a\u7684\u80c6\u56fa\u9187\u542b\u91cf\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(G \u548c H) Filipin III\u67d3\u8272\u663e\u793a\u7684\u80c6\u56fa\u9187\u542b\u91cf\uff08G\uff09\u548c\u6765\u81eashNC\u6216shFgf21 MC38\u80bf\u7624\u7684CD8+ <\/sup>T\u7ec6\u80de\u7684\u80c6\u56fa\u9187\u76f8\u5173\u57fa\u56e0\u7684\u5b9e\u65f6PCR\u5206\u6790\uff08H\uff09\uff08n = 6\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(I) shNC\u6216shFgf21 MC38\u80bf\u7624\u4e2d\u7ec8\u672b\u8017\u7aedT\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(J) \u5728\u6dfb\u52a0\u4e86\u03b2-\u73af\u7cca\u7cbe\u6216\u80c6\u56fa\u9187\u7684\u6761\u4ef6\u4e0b\uff0cOT-1 CD8+ <\/sup>T\u7ec6\u80de\u4e0e\u8868\u8fbeshNC\u6216shFgf21\u7684OVA\u80bf\u7624\u7ec6\u80de\u5171\u57f9\u517b\u540e\uff0cgranzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7684\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(K) \u6dfb\u52a0\u4e86\u03b2-\u73af\u7cca\u7cbe\u6216\u80c6\u56fa\u9187\u540e\uff0cOT-1 CTLs\u5b75\u80b2\u7684shNC\u6216shFgf21\u80bf\u7624\u7ec6\u80de\u7684\u6eb6\u89e3\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(L) \u7ecf\u8fc7\u6eb6\u5242\u5bf9\u7167\u5904\u7406\u6216\u8f9b\u4f10\u4ed6\u6c40\u5904\u7406\u7684shNC\u6216shFgf21 B16-OVA\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff08n = 5\u20136\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(M\u2013O) \u5728(L)\u4e2d\uff0cCD8+ <\/sup>T\u7ec6\u80de\u7684Filipin III\u80c6\u56fa\u9187\u67d3\u8272\uff08M\uff09\uff0c\u7ec8\u672b\u8017\u7aedT\u7ec6\u80de\uff08N\uff09\u548cgranzyme B+<\/sup>\u53caIFN\u03b3+ <\/sup>CD8+ <\/sup>T\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff08O\uff09\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(P) \u5728\u5e38\u89c4\u996e\u98df\uff08ND\uff09\u548c\u9ad8\u80c6\u56fa\u9187\u996e\u98df\uff08HCD\uff09\u5582\u517b\u7684\u5c0f\u9f20\u4e2d\uff0cshNC\u6216shFgf21 MC38\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff08n = 5\u20136\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(Q\u2013S) \u5728(P)\u4e2d\uff0cCD8+ T\u7ec6\u80de\u7684Filipin III\u80c6\u56fa\u9187\u67d3\u8272\uff08Q\uff09\uff0c\u7ec8\u672b\u8017\u7aedT\u7ec6\u80de\uff08R\uff09\u548cgranzyme B+<\/sup>\u53caIFN\u03b3+ <\/sup>CD8+ <\/sup>T\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff08S\uff09\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 5\u53ea\u5c0f\u9f20\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

\u6570\u636e\u4ee5\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u5448\u73b0\u3002*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001\uff0cns\u8868\u793a\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff0c\u901a\u8fc7\u5b66\u751ft\u68c0\u9a8c\uff08B, D, F, G, I, K, M, N, Q, \u548c R\uff09\u548c\u53cc\u5411\u65b9\u5dee\u5206\u6790\uff08C, E, H, J, L, O, P, \u548c S\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\u56fe 5\uff1aFGF21\u901a\u8fc7FGFR1-KLB\u53d7\u4f53\u7ef4\u6301AKT-mTORC1\u4fe1\u53f7\u7684\u8fc7\u5ea6\u6fc0\u6d3b\uff0c\u4ece\u800c\u5728CD8+ <\/sup>T\u7ec6\u80de\u4e2d\u52a0\u5267\u80c6\u56fa\u9187\u751f\u7269\u5408\u6210<\/strong><\/p>\n

(A) \u4f7f\u7528\u6297CD3\/CD28\u523a\u6fc072\u5c0f\u65f6\u540e\uff0c\u5bf9\u521d\u59cb\u6216\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2dFGFR1\u3001KLB\u548cFGFR2\u8868\u8fbe\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\u3002<\/p>\n

(B) \u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2dp-FGFR1\/FGFR1\u3001p-PI3K\/PI3K\u3001p-AKT\/AKT\u3001p-mTOR\/mTOR\u3001p-S6K\/S6K\u548cp-ERK\/ERK\u7684\u514d\u75ab\u5370\u8ff9\u5206\u6790\uff08n = 3\u4e2a\u72ec\u7acb\u5b9e\u9a8c\uff09\u3002<\/p>\n

(C\u2013E) \u5728\u6297CD3\/CD28\u523a\u6fc0\u540e\u7684\u6307\u5b9a\u65f6\u95f4\u70b9\uff0c\u4f7f\u7528\u5bf9\u7167\u57f9\u517b\u57fa(CM)\u6216\u6765\u81eashNC\u6216shFgf21 MC38\u80bf\u7624\u7ec6\u80de\u7684\u80bf\u7624\u6761\u4ef6\u57f9\u517b\u57fa(TCM)\u57f9\u517b\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2dp-AKT\u3001p-mTOR\u548cp-S6K\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(F) \u5728\u6297CD3\/CD28\u523a\u6fc072\u5c0f\u65f6\u540e\uff0crFGF21\u4ee5\u53caIgG\u5bf9\u7167\u6216\u6297FGF21\u5904\u7406\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2dp-AKT\u3001p-mTOR\u548cp-S6K\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(G) \u6765\u81eashNC\u6216shFgf21 MC38\u80bf\u7624\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2dp-AKT\u3001p-mTOR\u548cp-S6K\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(H \u548c I) \u5728rFGF21\u5904\u7406\uff0c\u6216\u52a0\u4e0a\u96f7\u5e15\u9709\u7d20\u5904\u740672\u5c0f\u65f6\u540e\uff0c\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2d\u80c6\u56fa\u9187\u76f8\u5173\u57fa\u56e0\u7684\u5b9e\u65f6PCR\u5206\u6790(H)\u548cFilipin III\u80c6\u56fa\u9187\u67d3\u8272(I)\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(J \u548c K) \u5728\u6297CD3\/CD28\u523a\u6fc072\u5c0f\u65f6\u540e\uff0c\u4f7f\u7528PBS\u6216rFGF21\u5904\u7406\u7684WT\u3001Fgfr1-\/-<\/sup>\u548cKlb-\/- <\/sup>CD8+ <\/sup>T\u7ec6\u80de\u4e2dp-AKT\u3001p-mTOR\u548cp-S6K (J)\u548cFilipin III\u80c6\u56fa\u9187\u67d3\u8272(K)\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(L) \u5728WT\u3001Fgfr1-\/-<\/sup>\u548cKlb-\/-<\/sup> OT-1 CTLs\u7ec6\u80de\u8fc7\u7ee7\u6027\u8f6c\u79fb\u540e\uff0c\u643a\u5e26shNC\u6216shFgf21 MC38-OVA\u80bf\u7624\u7684Rag2-\/-<\/sup>\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(M\u2013P) \u5728(L)\u4e2d\uff0cp-AKT\u3001p-mTOR\u3001p-S6K (M)\uff0cFilipin III\u80c6\u56fa\u9187\u67d3\u8272(N)\uff0c\u672b\u7aef\u8017\u7aedT\u7ec6\u80de\u7684\u767e\u5206\u6bd4(O)\u548cOT-1 CTLs\u4e2dgranzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7684\u767e\u5206\u6bd4(P)\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

\u6570\u636e\u4ee5\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u8868\u793a\u3002*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001\uff0cns\u8868\u793a\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff0c\u901a\u8fc7\u5b66\u751ft\u68c0\u9a8c(F, I, J, K, \u548c M\u2013O)\u548c\u53cc\u5411\u65b9\u5dee\u5206\u6790(C\u2013E, G, H, L, \u548c P)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe 6\uff1a\u6291\u5236FGF21\u6fc0\u6d3b\u7684mTORC1-SREBP1\u6062\u590dCD8+ T\u7ec6\u80de\u529f\u80fd<\/strong><\/p>\n

(A) \u5728rFGF21\u5904\u7406\uff0c\u6216\u52a0\u4e0a\u96f7\u5e15\u9709\u7d20\u5904\u740672\u5c0f\u65f6\u540e\uff0c\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ T\u7ec6\u80de\u4e2dSrebf1\u8868\u8fbe\u7684\u5b9e\u65f6PCR\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(B) \u5728rFGF21\u5904\u7406\uff0c\u6216\u52a0\u4e0a\u96f7\u5e15\u9709\u7d20\u5904\u740672\u5c0f\u65f6\u540e\uff0c\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2d\u7ec6\u80de\u6838\u7684\u6210\u719fSREBP1\uff08m-SREBP1\uff09\u548c\u7ec6\u80de\u8d28\u7684\u524d\u4f53SREBP1\uff08p-SREBP1\uff09\u7684\u514d\u75ab\u5370\u8ff9\u5206\u6790\uff08n = 3\u4e2a\u72ec\u7acb\u5b9e\u9a8c\uff09\u3002<\/p>\n

(C) SREBP1\u7684\u542f\u52a8\u5b50\u7ed3\u5408\u5206\u6790\u3002<\/p>\n

(D \u548c E) \u5728PBS\u6216rFGF21\u5904\u7406\u4e0b\uff0c\u6297CD3\/CD28\u6fc0\u6d3b\u7684shNC\u6216shSrebf1 CD8+ <\/sup>T\u7ec6\u80de\u4e2d\u80c6\u56fa\u9187\u76f8\u5173\u57fa\u56e0\uff08D\uff09\u7684\u5b9e\u65f6PCR\u5206\u6790\u548c\u80c6\u56fa\u9187\u7684Filipin III\u67d3\u8272\uff08E\uff09\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(F) \u7ecfCM\u3001TCM\u6216\u52a0\u4e0a\u96f7\u5e15\u9709\u7d20\u3001\u80c6\u56fa\u9187\u5904\u740672\u5c0f\u65f6\u540e\uff0c\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2dgranzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(G) \u7ecfrapamycin\u6216\u80c6\u56fa\u9187\u6dfb\u52a0\u540e\uff0c\u4e0e\u8868\u8fbeOVA\u7684\u80bf\u7624\u7ec6\u80de\u5171\u57f9\u517b12\u5c0f\u65f6\u7684OT-1 T\u7ec6\u80de\u4e2dgranzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7684\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(H) \u7ecfrapamycin\u6216\u80c6\u56fa\u9187\u9884\u5904\u740624\u5c0f\u65f6\u540e\uff0c\u4e0eOT-1 CTLs\u5171\u57f9\u517b\u7684\u8868\u8fbeOVA\u7684\u80bf\u7624\u7ec6\u80de\u7684\u6eb6\u89e3\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(I) \u5728rFGF21\u5904\u7406\uff0c\u6216\u52a0\u4e0a\u96f7\u5e15\u9709\u7d20\u3001\u80c6\u56fa\u9187\u5904\u740672\u5c0f\u65f6\u540e\uff0c\u6297CD3\/CD28\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2dgranzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(J) \u5728PBS\u6216rFGF21\u5904\u7406\u4e0b\uff0c\u6297CD3\/CD28\u6fc0\u6d3b\u7684shNC\u6216shSrebf1 CD8+ <\/sup>T\u7ec6\u80de\u4e2dgranzyme B+<\/sup>\u548cIFN\u03b3+<\/sup>\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

(K) \u7ecf\u5bf9\u7167\u6216\u80c6\u56fa\u9187\u9884\u5904\u740624\u5c0f\u65f6\u540e\uff0c\u4e0eshNC\u6216shSrebf1 OT-1 CTLs\u5171\u57f9\u517b\u7684\u8868\u8fbeOVA\u7684\u80bf\u7624\u7ec6\u80de\u7684\u6eb6\u89e3\u767e\u5206\u6bd4\uff08n = 3\u4e2a\u751f\u7269\u91cd\u590d\uff09\u3002<\/p>\n

\u6570\u636e\u4ee5\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u8868\u793a\u3002*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001\uff0cns\u8868\u793a\u65e0\u663e\u8457\u6027\u5dee\u5f02\uff0c\u901a\u8fc7\u5b66\u751ft\u68c0\u9a8c\uff08A, E, H, \u548c K\uff09\u548c\u53cc\u5411\u65b9\u5dee\u5206\u6790\uff08D, F, G, I, \u548c J\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe 7\uff1a\u4e2d\u548cFGF21\u53ef\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u5e76\u4e0e\u6297PD-1\u963b\u65ad\u53d1\u6325\u534f\u540c\u4f5c\u7528<\/strong><\/p>\n

(A) \u5728\u9759\u8109\u6ce8\u5c04\u4e86IgG\u5bf9\u7167\u6216\u6297FGF21\u7684WT\u5c0f\u9f20\u4e2d\uff0cMC38\u3001E0771\u548cB16F10\u80bf\u7624\u7684\u751f\u957f\u66f2\u7ebf\uff08n = 6\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(B \u548c C) \u5982(A)\u6240\u8ff0\uff0cCD8+ <\/sup>T\u7ec6\u80de\u4e2dp-AKT\u3001p-mTOR\u548cp-S6K (B)\u53caFilipin III\u80c6\u56fa\u9187\u67d3\u8272(C)\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 5\u20136\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(D \u548c E) \u5982(A)\u6240\u8ff0\uff0cCD8+ <\/sup>T\u7ec6\u80de\u4e2dCD8+<\/sup>T\u7ec6\u80de\u767e\u5206\u6bd4(D)\u548cgranzyme B+<\/sup>\u53caIFNg+ <\/sup>CD8+<\/sup>T\u7ec6\u80de(E)\u7684\u6d41\u5f0f\u7ec6\u80de\u5206\u6790\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(F) \u7ecfIgG\u5bf9\u7167\u3001\u6297PD-1\u3001\u6297FGF21\u6216\u6297PD-1\u8054\u5408\u6297FGF21\u5904\u7406\u7684MC38\u3001E0771\u548cB16F10\u80bf\u7624\u643a\u5e26\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(G) \u5982(F)\u6240\u8ff0\uff0c\u5c0f\u9f20\u5b58\u6d3b\u7684Kaplan-Meier\u5206\u6790\uff08n = 5\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

\u6570\u636e\u4ee5\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u8868\u793a\u3002*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001\uff0c\u901a\u8fc7\u5b66\u751ft\u68c0\u9a8c(C)\uff0c\u53cc\u5411\u65b9\u5dee\u5206\u6790(A, B, D, E, \u548c F)\uff0c\u4ee5\u53calog-rank\u68c0\u9a8c(G)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | Cell Metab.<\/span><\/span><\/section>\n
\u7b5b\u9009\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
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\u516c\u4f17\u53f7\u53d1\u90012024012319\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n


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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6742\u5fd7\u540d\u79f0\uff1aCell Metab. \u53d1\u8868\u65e5\u671f\uff1a2024.01.23 DOI\uff1a10.1016\/j.cmet.2024.01.005. PubMed\uff1ahttps:\/\/pubmed.ncb…<\/p>\n","protected":false},"author":1,"featured_media":5423,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[57],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5435"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5435"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5435\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5423"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5435"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}