{"id":5600,"date":"2024-03-23T15:25:05","date_gmt":"2024-03-23T07:25:05","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/03\/23\/cell-metab%ef%bc%9a%e9%a5%ae%e9%a3%9f%e4%b8%ad%e7%9a%84%e5%8f%8d%e5%bc%8f%e6%b2%b9%e9%85%b8%e9%80%9a%e8%bf%87acsl5%e5%a2%9e%e5%bc%ba%e8%82%bf%e7%98%a4%e6%8a%97%e5%8e%9f%e5%91%88%e9%80%92%e5%92%8c\/"},"modified":"2024-03-23T15:25:05","modified_gmt":"2024-03-23T07:25:05","slug":"cell-metab%ef%bc%9a%e9%a5%ae%e9%a3%9f%e4%b8%ad%e7%9a%84%e5%8f%8d%e5%bc%8f%e6%b2%b9%e9%85%b8%e9%80%9a%e8%bf%87acsl5%e5%a2%9e%e5%bc%ba%e8%82%bf%e7%98%a4%e6%8a%97%e5%8e%9f%e5%91%88%e9%80%92%e5%92%8c","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/03\/23\/cell-metab%ef%bc%9a%e9%a5%ae%e9%a3%9f%e4%b8%ad%e7%9a%84%e5%8f%8d%e5%bc%8f%e6%b2%b9%e9%85%b8%e9%80%9a%e8%bf%87acsl5%e5%a2%9e%e5%bc%ba%e8%82%bf%e7%98%a4%e6%8a%97%e5%8e%9f%e5%91%88%e9%80%92%e5%92%8c\/","title":{"rendered":"Cell Metab\uff1a\u996e\u98df\u4e2d\u7684\u53cd\u5f0f\u6cb9\u9178\u901a\u8fc7ACSL5\u589e\u5f3a\u80bf\u7624\u6297\u539f\u5448\u9012\u548c\u6297\u80bf\u7624\u514d\u75ab"},"content":{"rendered":"
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\u6742\u5fd7\u540d\u79f0<\/strong>\uff1aCell Metab.<\/span><\/p>\n

\u53d1\u8868\u65e5\u671f<\/strong>\uff1a2024.02.08<\/p>\n

DOI<\/strong>\uff1a10.1016\/j.cmet.2024.01.012.  <\/p>\n

PubMed<\/strong>\uff1ahttps:\/\/pubmed.ncbi.nlm.nih.gov\/38350448\/<\/p>\n

\u5f71\u54cd\u56e0\u5b50<\/strong>\uff1a29.0<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n<\/section>\n

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\u957f\u94fe\u8102\u80aa\u9178\uff08LCFAs\uff09\u53ca\u5176\u6fc0\u6d3b\u9176\uff0c\u9170\u8f85\u9176A\uff08CoA\uff09\u5408\u6210\u9176\u957f\u94fe\u5bb6\u65cf\uff08ACSL\uff09\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u4ecd\u7136\u4e0d\u751a\u660e\u4e86\u3002\u6211\u4eec\u53d1\u73b0\uff0cACSL5\u4f5c\u4e3a\u4e00\u79cd\u4f9d\u8d56\u514d\u75ab\u7684\u80bf\u7624\u6291\u5236\u56e0\u5b50\u53d1\u6325\u4f5c\u7528\u3002ACSL5\u8868\u8fbe\u4f7f\u80bf\u7624\u5bf9PD-1\u963b\u65ad\u7597\u6cd5\u5728\u4f53\u5185\u654f\u611f\uff0c\u5e76\u901a\u8fc7\u8c03\u8282\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53I\u7c7b\uff08MHC-I\uff09\u4ecb\u5bfc\u7684\u6297\u539f\u5448\u9012\uff0c\u5728\u4f53\u5916\u589e\u5f3aCD8+ <\/sup>T\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u901a\u8fc7\u7b5b\u9009ACSL5\u7684\u6f5c\u5728\u5e95\u7269\uff0c\u6211\u4eec\u8fdb\u4e00\u6b65\u786e\u5b9a\u4e86\u957f\u671f\u88ab\u8ba4\u4e3a\u5bf9\u4eba\u4f53\u5065\u5eb7\u6709\u5bb3\u7684\u53cd\u5f0f\u957f\u94fe\u8102\u80aa\u9178\u2014\u2014\u53cd\u5f0f\u6cb9\u9178\uff08EA\uff09\u2014\u2014\u53ef\u4ee5\u589e\u5f3aMHC-I\u8868\u8fbe\u3002\u8865\u5145EA\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u751f\u957f\u5e76\u589e\u5f3aPD-1\u963b\u65ad\u7597\u6cd5\u7684\u654f\u611f\u6027\u3002\u5728\u4e34\u5e8a\u4e0a\uff0cACSL5\u8868\u8fbe\u4e0e\u80ba\u764c\u60a3\u8005\u7684\u751f\u5b58\u7387\u6b63\u76f8\u5173\uff0c\u8840\u6d46EA\u6c34\u5e73\u4e5f\u53ef\u4ee5\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u7684\u6548\u7387\u3002\u6211\u4eec\u7684\u53d1\u73b0\u4e3a\u901a\u8fc7\u9488\u5bf9ACSL5\u6216\u901a\u8fc7\u996e\u98df\u8865\u5145EA\u6765\u8fdb\u884c\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff0c\u4ece\u800c\u589e\u5f3a\u514d\u75ab\u7597\u6cd5\u63d0\u4f9b\u4e86\u57fa\u7840\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u521b\u65b0\u6027\u53ca\u7814\u7a76\u610f\u4e49<\/strong><\/p>\n<\/section>\n

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\u8fd9\u7bc7\u6587\u7ae0\u7684\u6838\u5fc3\u521b\u65b0\u6027\u5728\u4e8e\u63ed\u793a\u4e86\u957f\u94fe\u8102\u80aa\u9178\uff08LCFAs\uff09\u53ca\u5176\u6fc0\u6d3b\u9176ACSL5\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u7279\u522b\u662fACSL5\u5728\u8c03\u8282\u80bf\u7624\u6297\u539f\u5448\u9012\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u7814\u7a76\u53d1\u73b0\uff0cACSL5\u4e0d\u4ec5\u662f\u4e00\u4e2a\u4f9d\u8d56\u514d\u75ab\u7684\u80bf\u7624\u6291\u5236\u56e0\u5b50\uff0c\u800c\u4e14\u5176\u8868\u8fbe\u80fd\u591f\u589e\u5f3aPD-1\u963b\u65ad\u7597\u6cd5\u7684\u6548\u679c\uff0c\u5e76\u5728\u4f53\u5916\u589e\u5f3aCD8+ <\/sup>T\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n

\u7814\u7a76\u7684\u53e6\u4e00\u4e2a\u521b\u65b0\u70b9\u662f\u8bc6\u522b\u51fa\u957f\u671f\u88ab\u8ba4\u4e3a\u5bf9\u4eba\u4f53\u6709\u5bb3\u7684\u53cd\u5f0f\u6cb9\u9178\uff08EA\uff09\u5b9e\u9645\u4e0a\u80fd\u901a\u8fc7ACSL5\u589e\u5f3aMHC-I\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u6291\u5236\u80bf\u7624\u751f\u957f\u5e76\u63d0\u9ad8PD-1\u963b\u65ad\u7597\u6cd5\u7684\u654f\u611f\u6027\u3002\u8fd9\u4e00\u53d1\u73b0\u98a0\u8986\u4e86\u5bf9\u53cd\u5f0f\u6cb9\u9178\u7684\u4f20\u7edf\u770b\u6cd5\uff0c\u5e76\u6307\u51fa\u901a\u8fc7\u996e\u98df\u8865\u5145EA\u53ef\u80fd\u662f\u4e00\u79cd\u65b0\u7684\u80bf\u7624\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n

\u7814\u7a76\u7684\u610f\u4e49\u5728\u4e8e\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u89d2\u5ea6\u548c\u65b9\u6cd5\u3002\u901a\u8fc7\u7784\u51c6ACSL5\u6216\u901a\u8fc7\u996e\u98df\u8865\u5145EA\u6765\u8fdb\u884c\u4ee3\u8c22\u91cd\u7f16\u7a0b\uff0c\u6709\u53ef\u80fd\u589e\u5f3a\u514d\u75ab\u7597\u6cd5\u7684\u6548\u679c\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u8868\u660eACSL5\u8868\u8fbe\u548c\u8840\u6d46EA\u6c34\u5e73\u53ef\u4f5c\u4e3a\u80ba\u764c\u60a3\u8005\u9884\u540e\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4e3a\u4e34\u5e8a\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u53c2\u8003\u4f9d\u636e\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u5f00\u53d1\u65b0\u7684\u6297\u80bf\u7624\u7b56\u7565\u63d0\u4f9b\u4e86\u79d1\u5b66\u4f9d\u636e\uff0c\u5177\u6709\u91cd\u8981\u7684\u7814\u7a76\u610f\u4e49\u548c\u4e34\u5e8a\u5e94\u7528\u524d\u666f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6570\u636e\u56fe<\/strong><\/p>\n<\/section>\n

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\u56fe 1\uff1aACSL5\u8868\u8fbe\u5bf9\u4f53\u5185\u80bf\u7624\u751f\u957f\u7684\u6291\u5236\u4f5c\u7528<\/strong><\/p>\n

(A) \u63cf\u8ff0C57BL\/6\u5c0f\u9f20\u4f53\u5185\u8868\u8fbe\u67d0\u79cdACSL\u6210\u5458\u7684B16F10\u80bf\u7624\u7684\u4e2a\u4f53\u751f\u957f\u60c5\u51b5\uff08\u6bcf\u7ec47\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(B\u2013D) \u5c55\u793a\u4e86\u5bf9\u7167\u7ec4\u548c\u8868\u8fbeACSL5-FLAG\u7684LLC\u7ec6\u80de\u4e2dACSL5\u7684\u514d\u75ab\u5370\u8ff9\u5206\u6790\u7ed3\u679c\uff08B\uff09\u3002\u6b64\u5916\uff0c\u8fd8\u5c55\u793a\u4e86\u5c0f\u9f20\u4f53\u5185LLC\u80bf\u7624\u7684\u4e2a\u4f53\u751f\u957f\u60c5\u51b5\uff08C\uff09\uff0c\u4ee5\u53ca\u5728\u5b9e\u9a8c\u7ec8\u70b9\u65f6\u6d4b\u91cf\u7684\u80bf\u7624\u91cd\u91cf\uff08D\uff09\uff08\u6bcf\u7ec47\u62168\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(E\u2013G) \u5c55\u793a\u4e86sgControl\u548csgACSL5\u6572\u51cf\u7684TDCL\u7ec6\u80de\u4e2dACSL5\u7684\u514d\u75ab\u5370\u8ff9\u5206\u6790\u7ed3\u679c\uff08E\uff09\u3002\u56fe\u4e2d\u8fd8\u663e\u793a\u4e86\u5c0f\u9f20\u4f53\u5185TDCL\u80bf\u7624\u7684\u4e2a\u4f53\u751f\u957f\u60c5\u51b5\uff08F\uff09\u4ee5\u53ca\u5728\u5b9e\u9a8c\u7ec8\u70b9\u65f6\u7684\u80bf\u7624\u91cd\u91cf\uff08G\uff09\uff08\u6bcf\u7ec49\u621610\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(H) \u5c55\u793a\u4e86\u4eba\u7c7bLUAD\u6807\u672c\u4e2dACSL5\u514d\u75ab\u7ec4\u5316(IHC)\u67d3\u8272\u7684\u4ee3\u8868\u6027\u56fe\u7247\u3002\u6bd4\u4f8b\u5c3a\uff0c\u4e0b\u65b9200\u6beb\u7c73\uff0c\u4e0a\u65b920\u6beb\u7c73\u3002<\/p>\n

(I) \u663e\u793a\u4e86\u8868\u8fbe\u9ad8\uff0841\u4f8b\uff09\u6216\u4f4e\uff0845\u4f8b\uff09ACSL5\u7684LUAD\u60a3\u8005\u7684Kaplan-Meier\u751f\u5b58\u66f2\u7ebf\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u3002\u56fe(A)\u3001(C)\u548c(F)\u4e2d\u7684p\u503c\u662f\u901a\u8fc7\u53cc\u5411ANOVA\u786e\u5b9a\u7684\uff0c\u56fe(D)\u548c(G)\u4e2d\u7684\u662f\u901a\u8fc7\u53cc\u5c3et\u68c0\u9a8c\u786e\u5b9a\u7684\uff0c\u56fe(I)\u4e2d\u7684\u662f\u901a\u8fc7\u5bf9\u6570\u79e9\u68c0\u9a8c\u786e\u5b9a\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\u56fe 2\uff1a\u80bf\u7624ACSL5\u4ecb\u5bfc\u5bf9ICB\u6cbb\u7597\u7684\u654f\u611f\u6027<\/strong><\/p>\n

(A) \u5728M-NSG\u5c0f\u9f20\u4e2d\uff0c\u8868\u8fbeACSL5-FLAG\u7684LLC\u80bf\u7624\u7684\u751f\u957f\u60c5\u51b5\u3002\u6bcf\u7ec45\u62166\u53ea\u5c0f\u9f20\u3002<\/p>\n

(B \u548c C) \u5728M-NSG\u5c0f\u9f20\uff08B\uff0c\u6bcf\u7ec45\u53ea\uff09\u6216Rag2-\/-<\/sup>\u5c0f\u9f20\uff08C\uff0c\u6bcf\u7ec45\u53ea\uff09\u4e2d\uff0csgACSL5 TDCL\u80bf\u7624\u7684\u751f\u957f\u60c5\u51b5\u3002<\/p>\n

(D) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u7ecf\u8fc7\u6297CD8\u03b1\u6297\u4f53\u5904\u7406\u7684\u5c0f\u9f20\u813e\u7ec6\u80de\u4e2dCD8+ <\/sup>\u548cCD4+ <\/sup>T\u7ec6\u80de\u4e9a\u7fa4\u3002<\/p>\n

(E) \u5728\u7ecf\u6297CD8\u03b1\u6297\u4f53\u5904\u7406\u7684\u5c0f\u9f20\u4e2d\uff0csgACSL5 TDCL\u80bf\u7624\u7684\u751f\u957f\u60c5\u51b5\uff08\u6bcf\u7ec47\u62168\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(F\u2013H) \u643a\u5e26sgControl\u6216sgACSL5 TDCL\u80bf\u7624\u7684\u5c0f\u9f20\u63a5\u53d7\u4e86\u6297PD-1\u6297\u4f53\u6cbb\u7597\u3002\u76d1\u6d4b\u4e86\u80bf\u7624\u4f53\u79ef\uff08F\u548cG\uff09\uff0c\u5e76\u5728\u5b9e\u9a8c\u7ec8\u70b9\u65f6\u6d4b\u91cf\u4e86\u80bf\u7624\u91cd\u91cf\uff08H\uff09\uff08\u6bcf\u7ec47\u62168\u53ea\u5c0f\u9f20\uff09\u3002<\/p>\n

(I\u2013K) \u5c0f\u63d0\u7434\u56fe\u6bd4\u8f83\u63a5\u53d7ICB\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u5e94\u7b54\u8005\u4e0e\u975e\u5e94\u7b54\u8005\u4e4b\u95f4ACSL5\u7684\u8868\u8fbe\u60c5\u51b5\uff08I\uff09\u3002\u4e3a\u8fd9\u4e9bACSL5\u8868\u8fbe\u9ad8\u6216\u4f4e\u7684\u80bf\u7624\u60a3\u8005\u7ed8\u5236\u7684Kaplan-Meier\u603b\u751f\u5b58\u7387\uff08J\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08K\uff09\u66f2\u7ebf\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u5dee\u3002\u56fe(A)\u2013(C)\u3001(E)\u548c(F)\u4e2d\u7684p\u503c\u901a\u8fc7\u53cc\u5411ANOVA\u786e\u5b9a\uff0c\u56fe(H)\u4e2d\u7684\u901a\u8fc7\u53cc\u5c3et\u68c0\u9a8c\u786e\u5b9a\uff0c\u56fe(I)\u4e2d\u7684\u901a\u8fc7Mann-Whitney\u68c0\u9a8c\u786e\u5b9a\uff0c\u56fe(J)\u548c(K)\u4e2d\u7684\u901a\u8fc7\u5bf9\u6570\u79e9\u68c0\u9a8c\u786e\u5b9a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe 3\uff1aACSL5\u589e\u5f3a\u80bf\u7624\u5bf9CTL\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u7684\u654f\u611f\u6027<\/strong><\/p>\n

(A\u2013F) \u5728sgControl\u6216sgACSL5 TDCL\u80bf\u7624\uff08A\u2013C\uff09\u4ee5\u53ca\u8868\u8fbeACSL5-FLAG\u7684LLC\u80bf\u7624\uff08D\u2013F\uff09\u4e2d\uff0cT\u7ec6\u80de\u6d78\u6da6\u7684\u6982\u51b5\u3002\u56fe\u5c55\u793a\u4e86CD45+<\/sup>\u7fa4\u4f53\u4e2dT\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff08A\u548cD\uff09\uff0c\u4ee5\u53ca\u8868\u8fbeTNF-\u03b1\uff08B\u548cE\uff09\u6216IFN-\u03b3\uff08C\u548cF\uff09\u7684T\u7ec6\u80de\u7684\u767e\u5206\u6bd4\uff08n = 6\u4e2a\u80bf\u7624\uff09\u3002<\/p>\n

(G) \u63cf\u8ff0\u4e86OVA+<\/sup>Luc+<\/sup>\u80bf\u7624\u7ec6\u80de\u4e0eOT-I\u7ec6\u80de\u5171\u57f9\u517b\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u3002<\/p>\n

(H\u2013J) \u5728\u6307\u5b9a\u7684\u6548\u5e94\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u6bd4\u4f8b\uff08E:T\uff09\u4e0b\uff0c\u5171\u57f9\u517b\u4e8630\u5c0f\u65f6\uff08H\uff09\u621648\u5c0f\u65f6\uff08I\u548cJ\uff09\u7684\u6307\u5b9aOVA+<\/sup>Luc+<\/sup>\u80bf\u7624\u7ec6\u80de\u4e0eOT-I\u7ec6\u80de\u7684\u76f8\u5bf9\u5b58\u6d3b\u7387\uff08n = 3\uff09\u3002<\/p>\n

(K\u548cL) \u5728\u4e0e\u4e0d\u540c\u6bd4\u4f8b\u7684OT-I\u7ec6\u80de\u5171\u57f9\u517b48\u5c0f\u65f6\u540e\uff0cOVA+<\/sup>Luc+<\/sup> Hepa1-6\uff08K\uff09\u6216B16F10\uff08L\uff09\u7684\u7ec6\u80de\u6b7b\u4ea1\u60c5\u51b5\uff08n = 3\uff09\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u3002\u56fe(A)\u2013(F)\u548c(H)\u2013(L)\u4e2d\u7684p\u503c\u901a\u8fc7\u53cc\u5411ANOVA\u8ba1\u7b97\u5f97\u51fa\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/section>\n<\/section>\n
\n

\u56fe 4\uff1aACSL5\u7f3a\u5931\u964d\u4f4e\u4e86\u7ec6\u80de\u8868\u9762MHC-I\u7684\u8868\u8fbe<\/strong><\/p>\n

(A) \u5728IFN-\u03b3\u5904\u7406\u4e0b\uff0csgControl\u548csgACSL5 OVA+<\/sup>Luc+ <\/sup>TDCL\u7ec6\u80de\u8868\u9762\u7684SIINFEKL-H-2Kb<\/sup>\u6c34\u5e73\uff08n = 3\uff09\u3002<\/p>\n

(B \u548c C) sgControl\u548csgACSL5 TDCL\u7ec6\u80de\u8868\u9762\u7684H-2Kb<\/sup>\/Db<\/sup>\u6c34\u5e73\uff08B\uff09\u6216\u603bH2-K1 mRNA\u6c34\u5e73\uff08C\uff09\uff08n = 3\uff09\u3002<\/p>\n

(D) \u5bf9\u7167\u7ec4\u548c\u8868\u8fbeACSL5-FLAG\u7684LLC\u7ec6\u80de\u8868\u9762\u7684H-2Kb<\/sup>\/Db<\/sup>\u6c34\u5e73\uff08n = 3\uff09\u3002<\/p>\n

(E) sgControl\u548csgACSL5 A549\u7ec6\u80de\u4e2dACLS5\u7684\u514d\u75ab\u5370\u8ff9\uff08\u5de6\uff09\u3002\u8fd9\u4e9b\u7ec6\u80de\u4e2dHLA-ABC mRNA\u6c34\u5e73\uff08\u4e2d\uff09\u548c\u7ec6\u80de\u8868\u9762\u4e30\u5ea6\uff08\u53f3\uff09\u88ab\u5b9a\u91cf\u5316\uff08n = 3\uff09\u3002<\/p>\n

(F) \u5728IFN-\u03b3\u4f5c\u7528\u4e0b\uff0c\u8868\u8fbescramble\u6216shACSL5\u7684TDCL\u7ec6\u80de\u8868\u9762\u7684H-2Kb<\/sup>\/Db<\/sup>\u6c34\u5e73\uff08n = 3\uff09\u3002<\/p>\n

(G) \u8868\u8fbescramble\u6216shACSL5\u7684SNU387\u7ec6\u80de\u8868\u9762\u7684HLA-ABC\u6c34\u5e73\uff08n = 3\uff09\u3002<\/p>\n

(H \u548c I) \u4ecesgControl\u6216sgACSL5 TDCL\u80bf\u7624\u4e2d\u5206\u79bb\u7684BFP+\u80bf\u7624\u7ec6\u80de\u7684\u8868\u9762H-2Kb<\/sup>\/Db<\/sup>\u4e30\u5ea6\uff08I, n = 5\u62167\uff09\u3002\u5e26\u6709H-2Kb<\/sup>\/Db<\/sup>\u67d3\u8272\u7684\u6d3b\u7ec6\u80deBFP+<\/sup>\u80bf\u7624\u7ec6\u80de\u7684\u5206\u9009\u7b56\u7565\uff08H\uff09\u3002<\/p>\n

(J \u548c K) \u5728IFN-\u03b3\u5904\u7406\u4e0b\uff0c\u8868\u8fbescramble\u6216shb2m\u7684sgControl\u6216sgACSL5 TDCL\u7ec6\u80de\u7684\u8868\u9762H-2Kb<\/sup>\/Db<\/sup>\u4e30\u5ea6\uff08J, n = 2\uff09\u3002\u8fd9\u4e9bTDCL\u80bf\u7624\u5728C57BL\/6\u5c0f\u9f20\u4e2d\u7684\u751f\u957f\uff08K, n = 9\u6bcf\u7ec4\uff09\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u3002\u56fe(A)\u2013(F)\u548c(I)\u4e2d\u7684p\u503c\u901a\u8fc7\u53cc\u5c3et\u68c0\u9a8c\u8ba1\u7b97\uff0c\u56fe(G)\u4e2d\u7684\u901a\u8fc7\u5355\u5411ANOVA\u8ba1\u7b97\uff0c\u56fe(K)\u4e2d\u7684\u901a\u8fc7\u53cc\u5411ANOVA\u8ba1\u7b97\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/section>\n<\/section>\n
\n

\u56fe 5\uff1aACSL5\u8c03\u63a7NLRC5\u4ecb\u5bfc\u7684\u6297\u539f\u5448\u9012<\/strong><\/p>\n

(A) sgControl\u4e0esgACSL5 Hepa1-6\u7ec6\u80de\u4e2d\u4e0d\u540c\u8868\u8fbe\u7684\u6297\u539f\u5448\u9012\u673a\u5236\uff08APM\uff09\u76f8\u5173\u57fa\u56e0\u7684\u70ed\u56fe\u3002<\/p>\n

(B) APM\u7279\u5f81\u7684\u5bcc\u96c6\u56fe\u3002<\/p>\n

(C) \u5728IFN-\u03b3\u4f5c\u7528\u4e0b\uff0csgControl\u6216sgACSL5 Hepa1-6\u7ec6\u80de\u4e2d\u5173\u952eAPM\u57fa\u56e0\u7684\u76f8\u5bf9mRNA\u6c34\u5e73\uff08n = 3\uff09\u3002<\/p>\n

(D) \u5728SKCM TCGA\u6570\u636e\u96c6\u4e2d\uff0cACSL5\u4e0eNLRC5 mRNA\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/p>\n

(E \u548c F) \u5728\u8868\u8fbescramble\u6216shNLRC5\u7684Hepa1-6\u7ec6\u80de\u4e2d\uff0c\u5173\u952eAPM\u57fa\u56e0\u7684\u76f8\u5bf9mRNA\u6c34\u5e73\uff08E\uff09\u548c\u7ec6\u80de\u8868\u9762H2Kb<\/sup>\/Db<\/sup>\u6c34\u5e73\uff08F\uff09\uff08n = 3\uff09\u3002<\/p>\n

(G) \u7ecfscramble\u6216shNLRC5\u5904\u7406\u7684OVA+<\/sup> B16F10\u7ec6\u80de\u4e0eOT-I\u7ec6\u80de\u5171\u57f9\u517b\u540e\u7684\u7ec6\u80de\u6b7b\u4ea1\u7387\uff08n = 3\uff09\u3002<\/p>\n

(H) \u5728C57BL\/6\u5c0f\u9f20\u4e2d\u8868\u8fbeshNLRC5\u7684TDCL\u80bf\u7624\u7684\u751f\u957f\uff08n = 5\u6bcf\u7ec4\uff09\u3002<\/p>\n

(I) \u5728293T\u7ec6\u80de\u4e2d\u8f6c\u67d3NLRC5\u8868\u8fbe\u8d28\u7c92\u540e\uff0c\u5e26\u6709FLAG\u6807\u7b7e\u7684NLRC5\u7684\u514d\u75ab\u5370\u8ff9\uff08\u5de6\uff09\u3002\u8fd9\u4e9b\u7ec6\u80de\u7684\u7ec6\u80de\u8868\u9762HLA-ABC\u6c34\u5e73\u88ab\u6d4b\u5b9a\uff08\u53f3\uff0cn = 3\uff09\u3002<\/p>\n

(J) \u9ad8\u8868\u8fbe\u4e0e\u4f4e\u8868\u8fbeNLRC5\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u603b\u751f\u5b58\u7387\u7684Kaplan-Meier\u66f2\u7ebf\u3002<\/p>\n

(K \u548c L) \u5728IFNg\u5904\u7406\u7684B16F10\u7ec6\u80de\u4e2d\uff0c\u8868\u8fbe\u7a7a\u8d28\u7c92\u3001ACSL5-FLAG\u6216ACSL5-FLAG\u52a0shNLRC5\u7684\u7ec6\u80de\u8868\u9762H2Kb<\/sup>\/Db<\/sup>\u6c34\u5e73\uff08K\uff0cn = 3\uff09\u3002\u8fd9\u4e9b\u80bf\u7624\u5728C57BL\/6\u5c0f\u9f20\u4e2d\u7684\u751f\u957f\uff08L\uff0cn = 8, 7, \u6216 6\u6bcf\u7ec4\uff09\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u3002\u56fe(C)\u548c(I)\u4e2d\u7684p\u503c\u901a\u8fc7\u53cc\u5c3et\u68c0\u9a8c\u786e\u5b9a\uff0c\u56fe(D)\u901a\u8fc7Pearson\u76f8\u5173\u7cfb\u6570\u786e\u5b9a\uff0c\u56fe(E)\u3001(F)\u548c(K)\u901a\u8fc7\u5355\u5411ANOVA\u786e\u5b9a\uff0c\u56fe(G)\u3001(H)\u548c(L)\u901a\u8fc7\u53cc\u5411ANOVA\u786e\u5b9a\uff0c\u56fe(J)\u901a\u8fc7\u5bf9\u6570\u79e9\u68c0\u9a8c\u786e\u5b9a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/section>\n<\/section>\n
\n

\u56fe 6\uff1aEA\u901a\u8fc7ACSL5-NLRC5\u8f74\u4fc3\u8fdb\u80bf\u7624\u6297\u539f\u5448\u9012\u5e76\u589e\u5f3a\u80bf\u7624\u5bf9CTL\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u7684\u654f\u611f\u6027<\/strong><\/p>\n

(A) \u5728IFN-\u03b3\u5904\u7406\u540e\uff0cSNU387\u7ec6\u80de\u7ecf\u4e0d\u540c\u6d53\u5ea6\u7684\u957f\u94fe\u8102\u80aa\u9178\uff08LCFAs\uff09\u5904\u7406\u540e\u7684\u7ec6\u80de\u8868\u9762HLA-ABC\u6c34\u5e73\uff08n = 2\uff09\u3002<\/p>\n

(B\u2013E) \u5728EA\u6216PA\u5904\u7406\u540e\u63a5IFN-\u03b3\u5904\u7406\u7684\u6307\u5b9a\u80bf\u7624\u7ec6\u80de\u7684H2Kb<\/sup>\/Db<\/sup>\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff08n = 3\uff09\u3002<\/p>\n

(F) \u7ecfEA\u548cIFN-\u03b3\u5904\u7406\u7684A549\u7ec6\u80de\u7684\u7ec6\u80de\u8868\u9762HLA-ABC\u6c34\u5e73\uff08n = 3\uff09\u3002<\/p>\n

(G\u2013J) \u6307\u5b9aHepa1-6\uff08G\u548cH\uff09\u6216LLC\u7ec6\u80de\uff08I\u548cJ\uff09\u4e2dNlrc5\uff08G\u548cI\uff09\u548cH2-K1\uff08H\u548cJ\uff09\u7684\u76f8\u5bf9mRNA\u6c34\u5e73\uff08n = 2\u20133\uff09\u3002<\/p>\n

(K) scramble\u6216shNLRC5\u8868\u8fbe\u7684LLC\u7ec6\u80de\u7684H2Kb\/Db\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff08n = 3\uff09\u3002<\/p>\n

(L) \u7ecfEA\u5904\u7406\u540e\u4e0eOT-I\u5171\u57f9\u517b\uff08E:T = 2:1\uff09\u7684\u6307\u5b9aHepa1-6\u7ec6\u80de\u7684\u7ec6\u80de\u6b7b\u4ea1\u60c5\u51b5\uff08n = 3\uff09\u3002<\/p>\n

(M) \u6307\u5b9aHepa1-6\u7ec6\u80de\u4e0aH-2Kb<\/sup>\/Db<\/sup>\u8868\u9762\u67d3\u8272\u7684\u4ee3\u8868\u6027\u56fe\u50cf\u3002<\/p>\n

(N) \u5728EA\u548cIFN-\u03b3\u5904\u7406\u4e0b\u6307\u5b9aSNU387\u7ec6\u80de\u4e2dHLA-ABC\u4e30\u5ea6\u7684\u53d8\u5316\u500d\u6570\uff08n = 3\uff09\u3002<\/p>\n

(O) \u7ecf2H17-EA\uff0850 mM\uff09\u5904\u740624\u5c0f\u65f6\u7684Hepa1-6\u7ec6\u80de\u4e2d2H17-EA-CoA\u7684\u76f8\u5bf9\u542b\u91cf\uff08n = 3\uff09\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u3002\u56fe(B)\u2013(D)\u548c(K)\u4e2d\u7684p\u503c\u901a\u8fc7\u5355\u5411ANOVA\u8ba1\u7b97\uff0c\u56fe(E)\u2013(J)\u548c(O)\u4e2d\u7684\u901a\u8fc7\u53cc\u5c3et\u68c0\u9a8c\u8ba1\u7b97\uff0c\u56fe(L)\u548c(N)\u4e2d\u7684\u901a\u8fc7\u53cc\u5411ANOVA\u8ba1\u7b97\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/section>\n<\/section>\n
\n

\u56fe 7\uff1aEA\u6291\u5236\u80bf\u7624\u751f\u957f\u5e76\u589e\u5f3aICB\u6cbb\u7597\u7684\u654f\u611f\u6027<\/strong><\/p>\n

(A) \u5728\u8865\u5145\u4e86\u4e59\u9187\uff08ETOH\uff09\u3001EA\u6216OA\uff0810 mg\/kg\uff09\u7684C57BL\/6\u5c0f\u9f20\u4e2d\uff0cB16F10\u80bf\u7624\u7684\u751f\u957f\u60c5\u51b5\uff08n = 9\u621610\u6bcf\u7ec4\uff09\u3002<\/p>\n

(B \u548c C) \u5728\u8865\u5145\u4e86ETOH\u62165 mg\/kg EA\u7684C57BL\/6\uff08B\uff0cn = 7\u62166\u6bcf\u7ec4\uff09\u6216M-NSG\u5c0f\u9f20\uff08C\uff0cn = 5\u6bcf\u7ec4\uff09\u4e2d\uff0cLLC\u80bf\u7624\u7684\u751f\u957f\u60c5\u51b5\u3002<\/p>\n

(D) EA\u5904\u7406\u7684B16F10\u80bf\u7624\u4e2dT\u7ec6\u80de\u6d78\u6da6\u7684\u6982\u51b5\uff08n = 5\uff09\u3002<\/p>\n

(E) \u4ece\u5bf9\u7167\u7ec4\u6216EA\u5904\u7406\u7684B16F10\u80bf\u7624\u4e2d\u5206\u79bb\u7684BFP+<\/sup>\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684H-2Kb<\/sup>\/Db<\/sup>\u4e30\u5ea6\uff08n = 8\u4e2a\u80bf\u7624\uff09\u3002<\/p>\n

(F) \u8868\u8fbescramble\u6216shb2m\u7684LLC\u7ec6\u80de\u8868\u9762\u7684H-2Kb<\/sup>\/Db<\/sup>\u6c34\u5e73\uff08\u5de6\uff09\u3002\u8fd9\u4e9b\u80bf\u7624\u5728\u63a5\u53d7EA\u5904\u7406\u7684\u5c0f\u9f20\u4e2d\u7684\u751f\u957f\u60c5\u51b5\uff08n = 9\u621610\u6bcf\u7ec4\uff09\u3002<\/p>\n

(G \u548c H) EA\u8865\u5145\u5bf9LLC\u80bf\u7624\u4e2dPD-1\u963b\u65ad\u6cbb\u7597\u7684\u6548\u679c\u3002\u76d1\u6d4b\u4e86\u80bf\u7624\u4f53\u79ef\uff08G, n = 7\u62168\uff09\uff0c\u5e76\u7ed8\u5236\u4e86\u751f\u5b58\u66f2\u7ebf\uff08H\uff09\u3002<\/p>\n

(I) \u5728C57BL\/6\u5c0f\u9f20\u643a\u5e26TDCL\u80bf\u7624\u4e2d\uff0cEA\u52a0PD-1\u963b\u65ad\u7684\u8054\u5408\u6cbb\u7597\uff08n = 9\u621610\u6bcf\u7ec4\uff09\u3002<\/p>\n

(J) \u5728\u5bf9ICB\u6cbb\u7597\u4e3a\u5e94\u7b54\u8005\uff08n = 47\uff09\u6216\u975e\u5e94\u7b54\u8005\uff08n = 22\uff09\u7684\u60a3\u8005\u8840\u6d46\u4e2d\uff0cEA\u6d53\u5ea6\u7684\u60c5\u51b5\u3002<\/p>\n

(K) \u5bf9\u8840\u6d46EA\u6c34\u5e73\u9ad8\u6216\u4f4e\u7684NSCLC\u60a3\u8005\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7684Kaplan-Meier\u66f2\u7ebf\u3002<\/p>\n

\u6570\u636e\u8868\u793a\u4e3a\u5747\u503c \u00b1 \u6807\u51c6\u8bef\u3002\u56fe(A)\u2013(D)\u3001(F, \u53f3)\u3001(G)\u548c(I)\u4e2d\u7684p\u503c\u901a\u8fc7\u53cc\u5411ANOVA\u8ba1\u7b97\uff0c\u56fe(E)\u548c(F, \u5de6)\u4e2d\u7684\u901a\u8fc7\u53cc\u5c3et\u68c0\u9a8c\u8ba1\u7b97\uff0c\u56fe(H)\u548c(K)\u4e2d\u7684\u901a\u8fc7\u5bf9\u6570\u79e9\u68c0\u9a8c\u8ba1\u7b97\uff0c\u56fe(J)\u4e2d\u7684\u901a\u8fc7Mann-Whitney\u68c0\u9a8c\u8ba1\u7b97\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | Cell Metab.<\/span><\/span><\/section>\n
\u7b5b\u9009\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
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\u516c\u4f17\u53f7\u53d1\u90012024020821\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n


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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6742\u5fd7\u540d\u79f0\uff1aCell Metab. \u53d1\u8868\u65e5\u671f\uff1a2024.02.08 DOI\uff1a10.1016\/j.cmet.2024.01.012.   PubMed\uff1ahttps:\/\/pub…<\/p>\n","protected":false},"author":1,"featured_media":5591,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[57],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5600"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5600"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5600\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5591"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5600"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}