{"id":5612,"date":"2024-04-05T15:55:28","date_gmt":"2024-04-05T07:55:28","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/04\/05\/cancer-cell%ef%bc%9a%e9%80%9a%e8%bf%87mrna%e6%8a%80%e6%9c%af%e7%bc%96%e7%a0%81%e6%8c%81%e4%b9%85%e6%80%a7il-2%e5%9c%a8mhc-i%e7%b1%bb%e5%88%86%e5%ad%90%e7%bc%ba%e9%99%b7%e7%99%8c%e7%97%87%e4%b8%ad\/"},"modified":"2024-04-05T15:55:28","modified_gmt":"2024-04-05T07:55:28","slug":"cancer-cell%ef%bc%9a%e9%80%9a%e8%bf%87mrna%e6%8a%80%e6%9c%af%e7%bc%96%e7%a0%81%e6%8c%81%e4%b9%85%e6%80%a7il-2%e5%9c%a8mhc-i%e7%b1%bb%e5%88%86%e5%ad%90%e7%bc%ba%e9%99%b7%e7%99%8c%e7%97%87%e4%b8%ad","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/04\/05\/cancer-cell%ef%bc%9a%e9%80%9a%e8%bf%87mrna%e6%8a%80%e6%9c%af%e7%bc%96%e7%a0%81%e6%8c%81%e4%b9%85%e6%80%a7il-2%e5%9c%a8mhc-i%e7%b1%bb%e5%88%86%e5%ad%90%e7%bc%ba%e9%99%b7%e7%99%8c%e7%97%87%e4%b8%ad\/","title":{"rendered":"Cancer Cell\uff1a\u901a\u8fc7mRNA\u6280\u672f\u7f16\u7801\u6301\u4e45\u6027IL-2\u5728MHC I\u7c7b\u5206\u5b50\u7f3a\u9677\u764c\u75c7\u4e2d\u53ef\u6062\u590d\u9488\u5bf9\u65b0\u6297\u539f\u7684CD8+ T\u7ec6\u80de\u53cd\u5e94"},"content":{"rendered":"
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\u524d\u671f\u7cbe\u5f69\u5185\u5bb9\uff1a<\/span><\/p>\n

Nature Cancer\uff1a\u80bf\u7624\u76f8\u5173\u9ad3\u7cfb\u7ec6\u80de\u4e0a\u7684Sirp\u03b1\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u72ec\u7acb\u4e8e\u5176\u4e0eCD47\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab<\/span><\/a><\/span><\/p>\n

Cell Metab\uff1a\u80bf\u7624\u5206\u6ccc\u7684FGF21\u901a\u8fc7\u91cd\u5851CD8+T\u7ec6\u80de\u7684\u80c6\u56fa\u9187\u4ee3\u8c22\u53d1\u6325\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/span><\/a><\/span><\/p>\n

Cell\uff1aSMARCAL1\u662f\u4fc3\u8fdb\u80bf\u7624\u514d\u75ab\u9003\u9038\u7684\u5929\u7136\u514d\u75ab\u4fe1\u53f7\u548cPD-L1\u8868\u8fbe\u7684\u53cc\u91cd\u8c03\u8282\u5668<\/span><\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6742\u5fd7\u540d\u79f0<\/strong>\uff1aCancer Cell<\/span><\/p>\n

\u53d1\u8868\u65e5\u671f<\/strong>\uff1a2024.03.01<\/p>\n

DOI<\/strong>\uff1a10.1016\/j.ccell.2024.02.013.<\/p>\n

PubMed<\/strong>\uff1ahttps:\/\/pubmed.ncbi.nlm.nih.gov\/38490213\/<\/p>\n

\u5f71\u54cd\u56e0\u5b50<\/strong>\uff1a50.3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n<\/section>\n

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\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\uff08MHC\uff09I\u7c7b\u6297\u539f\u5448\u9012\u7f3a\u9677\u662f\u764c\u75c7\u514d\u75ab\u9003\u9038\u7684\u5e38\u89c1\u673a\u5236\uff0c\u4f46\u5bf9\u5176\u673a\u5236\u548c\u89e3\u51b3\u8fd9\u4e00\u6311\u6218\u7684\u6f5c\u5728\u7b56\u7565\u4ecd\u7136\u4e86\u89e3\u4e0d\u8db3\u3002\u901a\u8fc7\u03b22-\u5fae\u7403\u86cb\u767d\uff08B2M\uff09\u7f3a\u9677\u7684\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\uff0c\u7814\u7a76\u8005\u53d1\u73b0MHC I\u7c7b\u7f3a\u5931\u5bfc\u81f4\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u5927\u91cf\u514d\u75ab\u8352\u6f20\u5316\u4ee5\u53ca\u5bf9\u514d\u75ab\u3001\u5316\u7597\u548c\u653e\u7597\u7684\u5e7f\u6cdb\u62b5\u6297\u3002\u8be5\u7814\u7a76\u8fd8\u5c55\u793a\u4e86\u901a\u8fc7mRNA\u6280\u672f\u7f16\u7801\u6301\u4e45\u6027IL-2\u8fdb\u884c\u6cbb\u7597\u53ef\u4ee5\u6062\u590d\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u3001IFN\u03b3\u4fc3\u8fdb\u7684\u9ad8\u5ea6\u708e\u75c7\u7684TME\u7279\u5f81\uff0c\u5e76\u4e14\u5f53\u4e0e\u9488\u5bf9\u80bf\u7624\u7684\u5355\u514b\u9686\u6297\u4f53\uff08mAB\uff09\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u53ef\u4ee5\u514b\u670d\u6cbb\u7597\u6297\u6027\u3002\u610f\u5916\u7684\u662f\uff0c\u8fd9\u79cd\u6cbb\u7597\u7684\u6709\u6548\u6027\u662f\u7531\u91ca\u653eIFN\u03b3\u7684CD8+ <\/sup>T\u7ec6\u80de\u9a71\u52a8\u7684\uff0c\u8fd9\u4e9b\u7ec6\u80de\u8bc6\u522b\u7531TME\u4e2d\u6d3b\u5316\u7684\u5de8\u566c\u7ec6\u80de\u4ea4\u53c9\u5448\u9012\u7684\u65b0\u6297\u539f\u3002\u5728IL-2\u6cbb\u7597\u4e0b\uff0c\u8fd9\u4e9b\u5de8\u566c\u7ec6\u80de\u83b7\u5f97\u4e86\u589e\u5f3a\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u548c\u5176\u4ed6M1\u8868\u578b\u76f8\u5173\u7279\u5f81\u3002\u8be5\u7814\u7a76\u7684\u53d1\u73b0\u5f3a\u8c03\u4e86\u5728\u6cbb\u7597MHC I\u7c7b\u7f3a\u9677\u764c\u75c7\u4e2d\u6062\u590d\u65b0\u6297\u539f\u7279\u5f02\u6027\u514d\u75ab\u5e94\u7b54\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u521b\u65b0\u6027\u53ca\u7814\u7a76\u610f\u4e49<\/strong><\/p>\n<\/section>\n

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\u8fd9\u7bc7\u6587\u7ae0\u7684\u6838\u5fc3\u521b\u65b0\u6027\u5728\u4e8e\u63ed\u793a\u4e86\u4e00\u79cd\u65b0\u7684\u764c\u75c7\u6cbb\u7597\u7b56\u7565\uff0c\u5373\u901a\u8fc7mRNA\u6280\u672f\u7f16\u7801\u7684\u957f\u6548IL-2\u6765\u6062\u590dMHC I\u7c7b\u5206\u5b50\u7f3a\u9677\u764c\u75c7\u4e2d\u9488\u5bf9\u65b0\u6297\u539f\u7684CD8+ <\/sup>T\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u3002\u6587\u7ae0\u7814\u7a76\u4e86\u03b22-\u5fae\u7403\u86cb\u767d\uff08B2M\uff09\u7f3a\u5931\u7684\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\uff0c\u53d1\u73b0MHC I\u7c7b\u5206\u5b50\u7684\u7f3a\u5931\u5bfc\u81f4\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u514d\u75ab\u8352\u6f20\u5316\u548c\u5bf9\u514d\u75ab\u3001\u5316\u7597\u548c\u653e\u7597\u7684\u5e7f\u6cdb\u62b5\u6297\u3002<\/p>\n

\u6587\u7ae0\u5c55\u793a\u4e86\u957f\u6548mRNA\u7f16\u7801\u7684IL-2\u6cbb\u7597\u80fd\u591f\u6062\u590dTME\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u3001\u4fc3\u8fdbIFN\u03b3\u9a71\u52a8\u7684\u9ad8\u5ea6\u708e\u75c7\u53cd\u5e94\uff0c\u5e76\u4e14\u5f53\u4e0e\u9488\u5bf9\u80bf\u7624\u7684\u5355\u514b\u9686\u6297\u4f53\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u80fd\u591f\u514b\u670d\u6cbb\u7597\u62b5\u6297\u3002\u610f\u5916\u7684\u53d1\u73b0\u662f\uff0c\u8fd9\u79cd\u6cbb\u7597\u7684\u6709\u6548\u6027\u7531\u80fd\u591f\u8bc6\u522b\u7531TME\u5185\u6d3b\u5316\u7684\u5de8\u566c\u7ec6\u80de\u8de8\u5448\u9012\u7684\u65b0\u6297\u539f\u7684IFN\u03b3\u91ca\u653eCD8+ <\/sup>T\u7ec6\u80de\u9a71\u52a8\u3002\u8fd9\u4e9b\u5de8\u566c\u7ec6\u80de\u5728IL-2\u6cbb\u7597\u4e0b\u83b7\u5f97\u4e86\u589e\u5f3a\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u548c\u5176\u4ed6M1\u8868\u578b\u76f8\u5173\u7684\u7279\u5f81\u3002<\/p>\n

\u7814\u7a76\u7684\u610f\u4e49\u5728\u4e8e\u5f3a\u8c03\u4e86\u5728\u6cbb\u7597MHC I\u7c7b\u7f3a\u9677\u764c\u75c7\u65f6\uff0c\u6062\u590d\u9488\u5bf9\u65b0\u6297\u539f\u7684\u7279\u5f02\u6027\u514d\u75ab\u5e94\u7b54\u7684\u91cd\u8981\u6027\u3002\u8fd9\u4e3a\u514b\u670d\u764c\u75c7\u514d\u75ab\u9003\u9038\u673a\u5236\u63d0\u4f9b\u4e86\u65b0\u7684\u7b56\u7565\uff0c\u5e76\u53ef\u80fd\u4e3aMHC I\u7c7b\u5206\u5b50\u7f3a\u9677\u764c\u75c7\u7684\u6cbb\u7597\u5f00\u8f9f\u65b0\u7684\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6570\u636e\u56fe<\/strong><\/p>\n<\/section>\n

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\u56fe1\uff1aMHC I\u7c7b\u7f3a\u5931\u80bf\u7624\u7684\u514d\u75ab\u8352\u6f20\u5316<\/strong><\/p>\n

(A) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u786e\u5b9aCT26\u6216CT26-B2m-\/-<\/sup>\u80bf\u7624\u4e2dT\u7ec6\u80de\u548cNK\u7ec6\u80de\u6e17\u900f\u7684\u65f6\u95f4\u52a8\u6001\uff08\u6bcf\u4e2a\u65f6\u95f4\u70b9n = 4-5\uff09\u3002<\/p>\n

(B) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u5728\u63a5\u79cd\u540e20\u5929\u5185\u786e\u5b9aCT26\u3001MC38\u6216B16F10\u91ce\u751f\u578b\uff08WT\uff09\u548cB2m-\/-<\/sup>\u80bf\u7624\u4e2d\u514d\u75ab\u7ec6\u80de\u7684\u6e17\u900f\u60c5\u51b5\uff08n = 8\uff09\u3002<\/p>\n

(C) \u901a\u8fc7\u03b1CD8\u514d\u75ab\u7ec4\u5316\uff08IHC\uff09\u6216\u514d\u75ab\u8367\u5149\uff08IF\uff09\u67d3\u8272\u4ee5\u53caNcr1\u539f\u4f4d\u6742\u4ea4\uff08ISH\uff09\uff0c\u5728\u63a5\u79cd19\u5929\u540e\u786e\u5b9aCT26\u6216MC38 WT\u548cB2m-\/-<\/sup>\u80bf\u7624\u4e2dCD8+ <\/sup>T\u7ec6\u80de\u548cNK\u7ec6\u80de\u7684\u6e17\u900f\uff08\u5c55\u793a\u4e86\u4ee3\u8868\u6027\u793a\u4f8b\uff1b\u6bcf\u884c\u4ee3\u8868\u4e00\u4e2a\u5355\u72ec\u7684\u80bf\u7624\uff09\u3002\u6bd4\u4f8b\u5c3a=100 mm\uff08IF\uff09\u621650 mm\uff08IHC, Ncr1 ISH\uff09\u3002<\/p>\n

(D) CT26\u3001MC38\u6216B16F10 WT\u548cB2m-\/-<\/sup>\u7ec6\u80de\u5728\u4f53\u5185\u7684\u751f\u957f\uff08n = 5\uff09\u3002<\/p>\n

(E) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u5728\u63a5\u79cd\u540e20\u5929\u5185\u786e\u5b9a\u6e17\u900fCT26\u6216MC38 WT\u548cB2m-\/-<\/sup>\u80bf\u7624\u7ec4\u7ec7\u4e2dCD8+ <\/sup>T\u7ec6\u80de\u7684PD-1\u8868\u8fbe\uff08n = 8\uff09\u3002<\/p>\n

(F) \u901a\u8fc7\u5b9a\u91cf\u5b9e\u65f6PCR\uff08qRT-PCR\uff09\uff0c\u5728\u63a5\u79cd\u540e19\u5929\u5185\u786e\u5b9aCT26\uff08n = 3\uff09\u6216MC38\uff08n = 5\uff09WT\u548cB2m-\/-<\/sup>\u80bf\u7624\u7ec4\u7ec7\u4e2d\u6240\u793a\u57fa\u56e0\u7684\u8868\u8fbe\u3002<\/p>\n

(G) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u5728\u63a5\u79cd\u540e20\u5929\u5185\u786e\u5b9aCT26\u6216MC38 WT\u548cB2m-\/-<\/sup>\u80bf\u7624\u7ec6\u80de\u4e2dPD-L1\u7684\u8868\u8fbe\uff08n = 8\uff09\u3002<\/p>\n

(H) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u5728\u63a5\u79cd\u540e20\u5929\u5185\u786e\u5b9a\u6e17\u900fCT26\u6216MC38 WT\u548cB2m-\/-<\/sup>\u80bf\u7624\u7684\u5de8\u566c\u7ec6\u80de\u4e2dPD-L1\u548cMHC II\u7c7b\u7684\u8868\u8fbe\uff08n = 8\uff09\u3002<\/p>\n

\u4ee5\u5747\u503c\u4f5c\u4e3a\u6c47\u603b\u7edf\u8ba1\u3002\u8bef\u5dee\u6761\u8868\u793a\u5747\u503c\u7684\u6807\u51c6\u8bef\u5dee\uff08SEM\uff09\u3002\u901a\u8fc7Grubb\u2019s\u68c0\u9a8c\u79fb\u9664\u4e86\u5355\u4e2a\u5f02\u5e38\u503c\uff08B\uff09\u3002\u901a\u8fc7\u4e24\u79cd\u65b9\u5f0fANOVA\u4e0eSidak\u2019s\u4e8b\u540e\u68c0\u9a8c\uff08A, D\uff09\u6216\u5b66\u751f\u7684\u53cc\u5c3e\u975e\u914d\u5bf9t\u68c0\u9a8c\uff08B, E, F, G, H\uff09\u786e\u5b9a\u7edf\u8ba1\u663e\u8457\u6027\u3002ns\uff0c\u4e0d\u663e\u8457\uff1b*p<\/em> < 0.05, **p<\/em> < 0.01, ***p<\/em> < 0.001, ****p<\/em> < 0.0001\u3002\u53e6\u89c1\u56feS1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe2\uff1aMHC I\u7c7b\u7f3a\u5931\u80bf\u7624\u7684\u6cbb\u7597\u62b5\u6297\u6027<\/strong><\/p>\n

(A\u2013F) \u5728\u63a5\u53d7\u4ee5\u4e0b\u6cbb\u7597\u540e\uff0c\u643a\u5e26\u6240\u793a\u4eb2\u672c\u6216B2m-\/-<\/sup>\u80bf\u7624\u53d8\u5f02\u4f53\u7684\u5c0f\u9f20\u7684\u5b58\u6d3b\u60c5\u51b5\uff1a\u03b1PD-1\/\u03b1CTLA4\u7ec4\u5408\u6cbb\u7597\u6216\u540c\u79cd\u578b\u5bf9\u7167\uff08A\uff1bn = 10\uff09\u3001\u03b1PD-1\u3001\u03b1CTLA4\u6216\u4e0d\u76f8\u5173\u5bf9\u7167\u5355\u514b\u9686\u6297\u4f53\uff08B\uff1bn = 10\uff09\u3001\u7f16\u7801gp70\u7684mRNA-LPX\u75ab\u82d7\u6216\u7a7a\u8f7d\u4f53mRNA-LPX\u4f5c\u4e3a\u5bf9\u7167\uff08C\uff1bn = 10\uff09\u3001\u5965\u6c99\u5229\u94c2\uff08OX\uff09\/\u6c1f\u5c3f\u5627\u5576\uff085-FU\uff09\u53cc\u836f\u6cbb\u7597\u6216\u8f66\u8f86\u5bf9\u7167\uff08D\uff1bn = 9\u201310\uff09\u3001OX\u6216\u8f66\u8f86\u5bf9\u7167\uff08E\uff1bn = 10\u201315\uff09\u3001\u5c40\u90e8\u653e\u7597\uff08LRT\uff09\uff0c\u5242\u91cf\u4e3a12 Gy\u62160 Gy\u4f5c\u4e3a\u5bf9\u7167\uff08F\uff1bn = 10\uff09\u3002CR\u8868\u793a\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n

(G) \u5728\u5c40\u90e8\u653e\u7597\uff08LRT\uff09\u540e9\u5929\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u786e\u5b9a\u8840\u6db2\u4e2dgp70\u7279\u5f02\u6027CD8+ <\/sup>T\u7ec6\u80de\u7684\u6570\u91cf\uff08n = 10\uff09\u3002<\/p>\n

\u4ee5\u5747\u503c\u4f5c\u4e3a\u6c47\u603b\u7edf\u8ba1\u3002\u901a\u8fc7\u5bf9\u6570\u79e9\u68c0\u9a8c\uff08A\u2013F\uff09\u6216\u5b66\u751f\u7684\u53cc\u5c3e\u975e\u914d\u5bf9t\u68c0\u9a8c\uff08G\uff09\u786e\u5b9a\u7edf\u8ba1\u663e\u8457\u6027\u3002ns\u8868\u793a\u4e0d\u663e\u8457\uff1b*p<\/em> < 0.05, **p<\/em> < 0.01, ***p<\/em> < 0.001, ****p<\/em> < 0.0001\u3002\u53e6\u89c1\u56feS1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n

\u56fe3\uff1a\u901a\u8fc7mAB\/IL-2\u6cbb\u7597\u9006\u8f6cMHC I\u7c7b\u7f3a\u5931\u80bf\u7624\u5bf9\u591a\u79cd\u6cbb\u7597\u65b9\u5f0f\u7684\u6297\u6027<\/strong><\/p>\n

(A) IL-2\u53ca\u5176\u4e0e\u767d\u86cb\u767d\u7ed3\u5408\u7684IL-2 mRNA\u7684\u793a\u610f\u56fe\uff0c\u5305\u62ec5’\u7aef\u5e3d\u5b50\u7ed3\u6784\u30015’\u548c3’\u975e\u7ffb\u8bd1\u533a\uff08UTR\uff09\u3001\u5f00\u653e\u9605\u8bfb\u6846\u67b6\u4e24\u4fa7\u4ee5\u53ca\u591a\u817a\u82f7\u9178\u5c3e\u5df4\uff08\u5de6\u56fe\uff09\uff0c\u4ee5\u53ca\u4e0e\u91cd\u7ec4\u86cb\u767d\u76f8\u6bd4\uff0c\u901a\u8fc7mRNA\u4f20\u9012\u7684\u957f\u6548IL-2\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff08\u53f3\u56fe\uff1bn = 3\uff09\u3002<\/p>\n

(B \u548c C) \u7ecf\u03b1Trp1\uff08B\uff09\u6216\u03b1Her2\uff08C\uff09\u5355\u514b\u9686\u6297\u4f53\u548cIL-2\u6cbb\u7597\u7684B16F10-B2m-\/-<\/sup>\uff08B\uff09\u6216MC38-Her2-B2m-\/-<\/sup>\uff08C\uff09\u80bf\u7624\u5c0f\u9f20\u7684\u751f\u5b58\u60c5\u51b5\uff0c\u6216\u8005\u5206\u522b\u4f7f\u7528\u8fd9\u4e24\u79cd\u5316\u5408\u7269\uff08n = 10\uff09\u3002CR\u8868\u793a\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n

(D) \u5f02\u8d28\u6027B16F10:B16F10-B2m-\/-<\/sup>\u80bf\u7624\u6a21\u578b\u7684\u6cbb\u7597\u548c\u5206\u6790\u65b9\u6848\u3002<\/p>\n

(E) \u63a5\u79cd\u5f02\u8d28\u6027B16F10:B16F10-B2m-\/-<\/sup>\u80bf\u7624\u5e76\u63a5\u53d7\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\/IL-2\u3001\u03b1PD-1\/\u03b1CTLA4\u7ec4\u5408\u6cbb\u7597\u6216\u56db\u8054\u6cbb\u7597\u7684\u5c0f\u9f20\u7684\u751f\u5b58\u60c5\u51b5\uff08n = 15\uff09\u3002<\/p>\n

(F) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\uff0c\u5728IFN\u03b3\u4f53\u5916\u523a\u6fc024\u5c0f\u65f6\u540e\uff0c\u786e\u5b9a\u8fbe\u5230\u7ec8\u70b9\u6807\u51c6\u7684\u5c0f\u9f20\u5f02\u8d28\u80bf\u7624\u4e2dMHC I\u7c7b+ B16F10\u7ec6\u80de\u7684\u6570\u91cf\uff08n = 3\u201314\uff09\u3002\u865a\u7ebf\u4ee3\u8868\u63a5\u79cd\u65f6MHC I\u7c7b+\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002<\/p>\n

(G \u548c H) \u7ecf\u03b1Her2\u5355\u514b\u9686\u6297\u4f53\/IL-2\u3001\u5965\u6c99\u5229\u94c2\uff08OX\uff09\u6216\u4e09\u8054\u7ec4\u5408\uff08G\uff1bn = 15\uff09\u6cbb\u7597\u7684MC38-Her2-B2m-\/-<\/sup>\u80bf\u7624\u5c0f\u9f20\u7684\u751f\u5b58\u60c5\u51b5\uff0c\u6216\u7ecf\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\/IL-2\u3001\u73af\u78f7\u9170\u80fa\uff08CP\uff09\u6216\u4e09\u8054\u7ec4\u5408\uff08H\uff1bn = 14\u201315\uff09\u6cbb\u7597\u7684B16F10-B2m-\/-<\/sup>\u80bf\u7624\u5c0f\u9f20\u7684\u751f\u5b58\u60c5\u51b5\u3002\u6240\u6709\u5b9e\u9a8c\u4e2d\u4f7f\u7528\u7f16\u7801\u767d\u86cb\u767d\u7684mRNA\u548c\u540c\u79cd\u578b\u5355\u514b\u9686\u6297\u4f53\u4f5c\u4e3a\u5bf9\u7167\u3002<\/p>\n

\u5747\u503c\u4f5c\u4e3a\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u3002\u8bef\u5dee\u6761\u4ee3\u8868SEM\u3002\u7edf\u8ba1\u663e\u8457\u6027\u901a\u8fc7\u5bf9\u6570\u79e9\u68c0\u9a8c\uff08B, C, E, G, H\uff09\u6216\u5355\u5411ANOVA\u914d\u5408Dunnett\u2019s\u4e8b\u540e\u68c0\u9a8c\uff08F\uff09\u786e\u5b9a\u3002ns\u8868\u793a\u4e0d\u663e\u8457\uff1b*p<\/em> < 0.05, **p<\/em> < 0.01, ***p<\/em> < 0.001, ****p<\/em> < 0.0001\u3002\u53e6\u89c1\u56feS2\u548cS3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n

\u56fe4\uff1aIL-2\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5f15\u53d1\u4e0eIFN\u76f8\u5173\u7684\u708e\u75c7\u7279\u5f81\u6807\u5fd7<\/strong><\/p>\n

(A) \u5b9e\u9a8c\u793a\u610f\u56fe\uff0c\u5206\u6790\u7ecf\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\u548cIL-2\u6216\u5176\u4e2d\u4efb\u4e00\u6cbb\u7597\u540e\u7684B16F10-B2m-\/-<\/sup>\u80bf\u7624\u3002<\/p>\n

(B \u548c C) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u786e\u5b9a\u7684\u6307\u5b9a\u80bf\u7624\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\uff08B\uff09\u548c\u6fc0\u6d3b\u6807\u5fd7\u7269\u4e0a\u8c03\uff08C\uff09\uff08n = 7\u20138\uff09\u3002<\/p>\n

(D) \u901a\u8fc7\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u786e\u5b9a\u7684\u4e0d\u540c\u6cbb\u7597\u7ec4\u4e2d\u7ec6\u80de\u7c7b\u578b\u7c07\u7684\u6bd4\u4f8b\uff08\u6bcf\u7ec4n = 3\u6c47\u603b\uff09\u3002<\/p>\n

(E) \u901a\u8fc7\u5b9a\u91cf\u5b9e\u65f6PCR\uff08qRT-PCR\uff09\u786e\u5b9a\u7684\u6574\u4e2a\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u8868\u8fbe\u7684log2\u500d\u53d8\u5316\uff08n = 5\uff1b\u6bcf\u884c\u4ee3\u8868\u4e00\u4e2a\u72ec\u7acb\u7684\u80bf\u7624\uff09\u3002<\/p>\n

(F) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u786e\u5b9a\u7684B16F10-B2m-\/-<\/sup>\u80bf\u7624\u7ec6\u80de\u4e2dPD-L1\u8868\u8fbe\uff08n = 7\u20138\uff09\u3002<\/p>\n

\u6240\u6709\u5b9e\u9a8c\u4e2d\u5747\u4f7f\u7528\u7f16\u7801\u767d\u86cb\u767d\u7684mRNA\u548c\u540c\u79cd\u578b\u5355\u514b\u9686\u6297\u4f53\u4f5c\u4e3a\u5bf9\u7167\u3002<\/p>\n

\u5747\u503c\u4f5c\u4e3a\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u3002\u901a\u8fc7Grubb\u2019s\u68c0\u9a8c\u79fb\u9664\u5355\u4e2a\u5f02\u5e38\u503c\uff08B\uff09\u3002\u7edf\u8ba1\u663e\u8457\u6027\u901a\u8fc7Kruskal-Wallis\u68c0\u9a8c\u4e0eDunn\u2019s\u4e8b\u540e\u68c0\u9a8c\uff08B\uff09\u6216\u5355\u5411ANOVA\u4e0eDunnett\u2019s\u4e8b\u540e\u68c0\u9a8c\uff08C, F\uff09\u786e\u5b9a\u3002ns\u8868\u793a\u4e0d\u663e\u8457\uff1b*p<\/em> < 0.05, **p<\/em> < 0.01, ***p<\/em> < 0.001, ****p<\/em> < 0.0001\u3002\u53e6\u89c1\u56feS4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n

\u56fe5\uff1aCD8+ <\/sup>T\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u5728mAB\/IL-2\u5904\u7406\u7684\u5c0f\u9f20\u4e2d\u6392\u65a5MHC I\u7c7b\u7f3a\u5931\u80bf\u7624\u4e2d\u53d1\u6325\u6838\u5fc3\u4f5c\u7528<\/strong><\/p>\n

(A\u2013C) \u7528\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\u548cIL-2\u6cbb\u7597\u643a\u5e26B16F10-B2m-\/-<\/sup>\u80bf\u7624\u7684\u5c0f\u9f20\uff0c\u5e76\u6d88\u8017\u7279\u5b9a\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u540e\u7684\u5b58\u6d3b\u60c5\u51b5\u3002\u5bf9NK1.1\u548cLy6G\uff08A\uff1bn = 8\u201315\uff09\u3001CD4\u3001CSF1R\u548cCD90.2\uff08B\uff1bn = 10\u201315\uff09\u6216IFN\u03b1\u548cCD8\uff08C\uff1bn = 8\u201315\uff09\u8fdb\u884c\u4e86\u6d88\u8017\/\u4e2d\u548c\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u3002\u5bf9\u7167\u7ec4\u6ce8\u5c04\u4e86\u65e0\u5173\u7684\u5355\u514b\u9686\u6297\u4f53\u3002CR\u8868\u793a\u5b8c\u5168\u7f13\u89e3\u3002<\/p>\n

(D) \u7ecf\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\u548cIL-2\u8054\u5408\u6cbb\u7597\u6216\u5176\u4e2d\u4efb\u4e00\u6cbb\u7597\u540e\uff0c\u4eceB16F10-B2m-\/-<\/sup>\u80bf\u7624\u4e2d\u5206\u79bb\u51fa\u7684CD8+<\/sup> TILs\u4e2d\u9009\u5b9a\u57fa\u56e0\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u901a\u8fc7\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u786e\u5b9a\uff08\u6bcf\u7ec4n = 3\u6c47\u603b\uff09\u3002\u6cbb\u7597\u4e8e\u63a5\u79cd\u540e9\u5929\u5f00\u59cb\uff0c\u5206\u6790\u4e8e\u63a5\u79cd\u540e\u7b2c20\u5929\u8fdb\u884c\u3002<\/p>\n

(E) \u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u6d4b\u91cf\uff0c\u6cbb\u7597\u540eB16F10-B2m-\/-<\/sup>\u80bf\u7624\u4e2d\u6e17\u900f\u7684\u5de8\u566c\u7ec6\u80de\u7684M1\/M2\u6bd4\u4f8b\uff0c\u6cbb\u7597\u5305\u62ec\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\u548cIL-2\u8054\u5408\u6216\u5176\u4e2d\u4efb\u4e00\u6cbb\u7597\u5904\u7406\u3002\u6cbb\u7597\u4e8e\u63a5\u79cd\u540e9\u5929\u5f00\u59cb\uff0c\u5206\u6790\u4e8e\u63a5\u79cd\u540e\u7b2c20\u5929\u8fdb\u884c\u3002<\/p>\n

(F) \u70ed\u56fe\u663e\u793a\u4e86\u63a5\u79cd\u540e\u7b2c20\u5929\uff0c\u901a\u8fc7\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u6d4b\u91cf\u7684B16F10-B2m-\/-<\/sup>\u80bf\u7624\u4e2d\u5de8\u566c\u7ec6\u80de\u4e2d\u524d20\u4e0a\u8c03\u548c\u524d20\u4e0b\u8c03\u57fa\u56e0\u7684\u8868\u8fbe\uff08\u6bcf\u7ec4n = 3\u6c47\u603b\uff09\u3002\u6cbb\u7597\u4e8e\u63a5\u79cd\u540e9\u5929\u5f00\u59cb\uff0c\u5305\u62ec\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\u548cIL-2 mRNA\u6216\u5176\u4e2d\u4efb\u4e00\u5355\u4e00\u5316\u5408\u7269\u3002<\/p>\n

\u6240\u6709\u5b9e\u9a8c\u4e2d\u5747\u4f7f\u7528\u7f16\u7801\u767d\u86cb\u767d\u7684mRNA\u548c\u540c\u79cd\u578b\u5355\u514b\u9686\u6297\u4f53\u4f5c\u4e3a\u5bf9\u7167\u3002<\/p>\n

\u5747\u503c\u4f5c\u4e3a\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u3002\u901a\u8fc7Grubb\u2019s\u68c0\u9a8c\u79fb\u9664\u5355\u4e2a\u5f02\u5e38\u503c\uff08E\uff09\u3002\u7edf\u8ba1\u663e\u8457\u6027\u901a\u8fc7\u5bf9\u6570\u79e9\u68c0\u9a8c\uff08A\u81f3C\uff09\u6216\u5355\u5411ANOVA\u914d\u5408Dunnett\u2019s\u4e8b\u540e\u68c0\u9a8c\uff08E\uff09\u786e\u5b9a\u3002ns\u8868\u793a\u4e0d\u663e\u8457\uff1b*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001\u3002\u53e6\u89c1\u56feS5\u548cS6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n

\u56fe6\uff1aIL-2\u6fc0\u6d3b\u7684CD8+ <\/sup>T\u7ec6\u80de\u548c\u5448\u9012\u80bf\u7624\u65b0\u6297\u539f\u7684\u5de8\u566c\u7ec6\u80de\u8fdb\u884c\u7279\u5f02\u6027\u4ea4\u6d41<\/strong><\/p>\n

(A) \u70b9\u56fe\uff08\u5de6\uff09\u548c\u7279\u5f81\u56fe\uff08\u53f3\uff09\u5c55\u793a\u4e86mAB\/IL-2\u5904\u7406\u7684B16F10-B2m-\/-<\/sup>\u80bf\u7624\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\u7684\u6240\u6709\u7ec6\u80de\u7c07\u4e2dIfng\u8868\u8fbe\u60c5\u51b5\uff0c\u8fd9\u662f\u901a\u8fc7\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u786e\u5b9a\u7684\uff08\u6bcf\u7ec4n = 3\u6c47\u603b\uff09\u3002\u6cbb\u7597\u5728\u63a5\u79cd\u540e9\u5929\u5f00\u59cb\uff0c\u5206\u6790\u5728\u63a5\u79cd\u540e\u7b2c20\u5929\u8fdb\u884c\u3002<\/p>\n

(B) \u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u6d4b\u91cf\uff0c\u5728\u63a5\u79cd\u540e9\u5929\u5f00\u59cb\u6cbb\u7597\u5e76\u5728\u63a5\u79cd\u540e\u7b2c18\u5929\u8fdb\u884c\u5206\u6790\u7684mAB\/IL-2\u5904\u7406\u5c0f\u9f20\u4e2d\uff0c\u6ce8\u5c04\u9488\u5bf9CD8\u6216IFN\u03b3\u6216\u65e0\u5173\u5bf9\u7167\u5355\u514b\u9686\u6297\u4f53\u540e\uff0cB16F10-B2m-\/-<\/sup>\u80bf\u7624\u6d78\u6da6\u5de8\u566c\u7ec6\u80de\u7684M1\/M2\u6bd4\u4f8b\uff08n = 9\u201310\uff09\u3002<\/p>\n

(C) \u5728\u63a5\u79cd\u540e\u7b2c15\u5929\u8fdb\u884c\u5355\u6b21\u03b1Trp1\u5355\u514b\u9686\u6297\u4f53\u548cIL-2\u6216\u5176\u4e2d\u4efb\u4e00\u6cbb\u75973\u5929\u540e\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u91cf\u5316\u6d4b\u5b9a\u6d78\u6da6B16F10-Ova-B2m-\/-<\/sup>\u80bf\u7624\u7684\u5de8\u566c\u7ec6\u80de\u4e0aH2-Kb\/SIINFEKL\u590d\u5408\u7269\u7684\u6570\u91cf\uff08n = 8\uff09\u3002\u7f16\u7801\u767d\u86cb\u767d\u7684mRNA\u548c\u540c\u79cd\u578b\u5355\u514b\u9686\u6297\u4f53\u4f5c\u4e3a\u5bf9\u7167\u3002<\/p>\n

(D) \u5b9e\u9a8c\u793a\u610f\u56fe\uff0c\u5206\u6790\u4ece\u643a\u5e26MC38-Her2-B2m-\/-<\/sup>\u80bf\u7624\u7684\u5c0f\u9f20\u4e2d\u5206\u79bb\u51fa\u7684\u5de8\u566c\u7ec6\u80de\u5448\u9012\u65b0\u6297\u539f\u7684\u80fd\u529b\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u5728\u63a5\u79cd\u540e\u7b2c20\u5929\u88ab\u5206\u6790\u3002\u6cbb\u7597\u5728\u63a5\u79cd\u540e\u7b2c9\u5929\u5f00\u59cb\uff0c\u4f7f\u7528\u03b1Her2\u5355\u514b\u9686\u6297\u4f53\u548cIL-2\u8054\u5408\u6216\u5176\u4e2d\u4efb\u4e00\u79cd\u8fdb\u884c\u5904\u7406\u3002<\/p>\n

(E) CD8+ TILs\u4e0eBMDCs\u5355\u72ec\u5171\u57f9\u517b\u6216\u5728\u65b0\u6297\u539f\u80bd\u6bb5\u6216\u6307\u5b9a\u80bf\u7624\u7ec6\u80de\u7cfb\u5b58\u5728\u4e0b\u5171\u57f9\u517b\u7684IFN\u03b3 ELISpot\u68c0\u6d4b\uff08n = 8\uff09\u3002<\/p>\n

(F) \u4ece\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5206\u79bb\u51fa\u7684\u5de8\u566c\u7ec6\u80de\u4e0e\u63a5\u79cd\u7a7a\u8f7d\u4f53\u3001Rpl18-\u6216Adpgk\u7f16\u7801RNA-LPX\u7684\u5c0f\u9f20\u7684CD8+ <\/sup>T\u7ec6\u80de\u5171\u57f9\u517b\u7684IFN\u03b3 ELISpot\u68c0\u6d4b\uff08n = 8\uff09\u3002<\/p>\n

\u5747\u503c\u4f5c\u4e3a\u6c47\u603b\u7edf\u8ba1\u6570\u636e\u3002\u901a\u8fc7Grubb\u2019s\u68c0\u9a8c\u79fb\u9664\u5355\u4e2a\u5f02\u5e38\u503c\uff08B\uff09\u3002\u7edf\u8ba1\u663e\u8457\u6027\u901a\u8fc7\u5355\u5411ANOVA\u914d\u5408Dunnett\u2019s\u4e8b\u540e\u68c0\u9a8c\u786e\u5b9a\u3002ns\u8868\u793a\u4e0d\u663e\u8457\uff1b*p<\/em> < 0.05, **p<\/em> < 0.01, ***p<\/em> < 0.001, ****p<\/em> < 0.0001\u3002\u53e6\u89c1\u56feS6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | Cancer Cell<\/span><\/section>\n
\u7b5b\u9009\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
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\u516c\u4f17\u53f7\u53d1\u90012024030112\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n


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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u524d\u671f\u7cbe\u5f69\u5185\u5bb9\uff1a Nature Cancer\uff1a\u80bf\u7624\u76f8\u5173\u9ad3\u7cfb\u7ec6\u80de\u4e0a\u7684Sirp\u03b1\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u72ec\u7acb\u4e8e\u5176\u4e0eCD47\u76f8\u4e92\u4f5c\u7528\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab Cell Metab\uff1a\u80bf\u7624\u5206\u6ccc\u7684FGF21\u901a\u8fc7\u91cd\u5851C…<\/p>\n","protected":false},"author":1,"featured_media":5604,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[57],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5612"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5612"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5612\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5604"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5612"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}