{"id":5615,"date":"2023-12-04T08:42:19","date_gmt":"2023-12-04T00:42:19","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2023\/12\/04\/2023%e5%b9%b4%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%ef%bc%88aacr%ef%bc%89%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e4%b8%8e%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%b9%b4\/"},"modified":"2023-12-04T08:42:19","modified_gmt":"2023-12-04T00:42:19","slug":"2023%e5%b9%b4%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%ef%bc%88aacr%ef%bc%89%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e4%b8%8e%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%b9%b4","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2023\/12\/04\/2023%e5%b9%b4%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%ef%bc%88aacr%ef%bc%89%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e4%b8%8e%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%b9%b4\/","title":{"rendered":"2023\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u80bf\u7624\u514d\u75ab\u4e0e\u514d\u75ab\u6cbb\u7597\u5e74\u4f1a-\u4e3b\u9898\u56db\uff1a\u514d\u75ab\u8c03\u8282"},"content":{"rendered":"
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\u4e0a\u671f\u94fe\u63a5\uff1a<\/strong><\/span><\/p>\n

2023\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u80bf\u7624\u514d\u75ab\u4e0e\u514d\u75ab\u6cbb\u7597\u5e74\u4f1a-\u4e3b\u9898\u4e09\uff1a\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883<\/span><\/a><\/span><\/p>\n

2023\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u80bf\u7624\u514d\u75ab\u4e0e\u514d\u75ab\u6cbb\u7597\u5e74\u4f1a-\u4e3b\u9898\u4e8c\uff1a\u7ec6\u80de\u56e0\u5b50\u7597\u6cd5<\/span><\/a><\/span><\/p>\n

2023\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u80bf\u7624\u514d\u75ab\u4e0e\u514d\u75ab\u6cbb\u7597\u5e74\u4f1a-\u4e3b\u9898\u4e00\uff1aT\u7ec6\u80de\u7597\u6cd5<\/span><\/a><\/span><\/p>\n

2023\u5e74\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u80bf\u7624\u514d\u75ab\u4e0e\u514d\u75ab\u6cbb\u7597\u5e74\u4f1a-\u4e3b\u9898\u6f14\u8bb2\uff1a\u8ffd\u8e2aT\u7ec6\u80de\u8017\u7aed<\/span><\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1. <\/strong>\u514d\u75ab\u539f\u578b\u53ca\u764c\u75c7\u4e2d\u9ad3\u7cfb\u751f\u7269\u5b66\u7684\u8f6c\u53d8\u8303\u5f0f<\/strong><\/p>\n

\u9a6c\u4fee\u00b7\u514b\u9c81\u6885\u5c14-\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u6d77\u4f26\u00b7\u8fea\u52d2\u5bb6\u5ead\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\uff0c\u65e7\u91d1\u5c71\uff0c\u52a0\u5229\u798f\u5c3c\u4e9a<\/strong><\/span>
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\u5728\u5173\u4e8e\u764c\u75c7\u4e2d\u7684\u514d\u75ab\u539f\u578b\u548c\u9ad3\u7cfb\u751f\u7269\u5b66\u7684\u8f6c\u53d8\u6a21\u5f0f\u7684\u8ba8\u8bba\u4e2d\uff0cMatthew Krummel – \u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821Helen Diller\u5bb6\u5ead\u7efc\u5408\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u5458\uff0c\u5f3a\u8c03\u4e86\u9700\u8981\u8d85\u8d8a\u514d\u75ab\u53cd\u5e94\u88ab\u89c6\u4e3a\u8010\u53d7\u6216\u8005\u6bc1\u706d\u7684\u4f20\u7edf\u89c2\u5ff5\uff0c\u5e76\u5f3a\u8c03\u4e86\u5404\u79cd\u514d\u75ab\u539f\u578b\u7684\u65b0\u5174\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u539f\u578b\u662f\u4e00\u79cd\u5728\u591a\u79cd\u7ec4\u7ec7\u7c7b\u578b\u4e2d\u76f8\u5173\u8054\u7684\u7ec6\u80de\u96c6\u5408\u7684\u9ad8\u9636\u72b6\u6001\u3002\u4f8b\u5982\uff0cTreg\/Th17\u548cDCs\u8c03\u8282\u5171\u751f\u5fae\u751f\u7269\u5e73\u8861\uff0c\u6216\u8005\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u4ecb\u5bfc\u4f24\u53e3\u6108\u5408\u3002\u4f5c\u4e3a\u80bf\u7624-\u514d\u75ab\u539f\u578b\u7684\u4e00\u4e2a\u4f8b\u5b50\uff0cKrummel\u9996\u5148\u5c55\u793a\u4e86\u4ed6\u7684\u56e2\u961f\u5173\u4e8ecDC1\u5728\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u89d2\u8272\u7684\u65e9\u671f\u5de5\u4f5c\uff0c\u5e76\u8868\u660ecDC1\u5bf9\u4e8e\u523a\u6fc0\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684CD8+ <\/sup>T\u7ec6\u80de\u7684\u589e\u6b96\u81f3\u5173\u91cd\u8981\uff0c\u5e76\u4e14\u548c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u5bf9\u6297PD-L1\u7684\u53cd\u5e94\u4ee5\u53ca\u751f\u5b58\u7387\u7684\u63d0\u9ad8\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u53d1\u73b0\u5728\u5404\u79cd\u764c\u75c7\u4e2d\u7684\u4e3b\u5bfc\u514d\u75ab\u539f\u578b\uff0cKrummel\u548c\u4ed6\u7684\u540c\u4e8b\u4eec\u4f7f\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u5bf9\u4e0d\u540c\u764c\u75c7\u7684\u5b9e\u4f53\u80bf\u7624\u6837\u672c\u8fdb\u884c\u5206\u6790\u548c\u6392\u5e8f\uff0c\u7136\u540e\u5bf9\u4e0d\u540c\u7fa4\u4f53\u8fdb\u884cRNA\u6d4b\u5e8f\u3002\u5bf9300\u4e2a\u75c5\u4eba\u6837\u672c\u7684\u5206\u6790\u663e\u793a\u51fa\u708e\u75c7\uff08CD8\u4e30\u5bcc\uff09\u548c\u8352\u829c\uff08CD8\u8d2b\u4e4f\uff09\u80bf\u7624\u7684\u660e\u663e\u96c6\u7fa4\u3002\u867d\u7136\u80be\u764c\u5927\u90e8\u5206\u5728\u708e\u75c7\u96c6\u7fa4\u4e2d\uff0c\u4f46\u662f\u4e00\u4e9b\u80be\u764c\u6837\u672c\u51fa\u73b0\u5728\u514d\u75ab\u8352\u6f20\u96c6\u7fa4\u4e2d\u3002\u7c7b\u4f3c\u7684\u7ed3\u679c\u4e5f\u5728\u80ba\u764c\u548c\u9ed1\u8272\u7d20\u7624\u4e2d\u53d1\u73b0\uff0c\u8fd9\u8868\u660e\u80bf\u7624\u7c7b\u578b\u5e76\u4e0d\u5b9a\u4e49\u539f\u578b\u3002\u7136\u800c\uff0c\u539f\u578b\u786e\u5b9e\u4e0e\u7279\u5b9a\u7684\u514d\u75ab\u751f\u7269\u5b66\uff08\u7279\u5b9a\u514d\u75ab\u7fa4\u4f53\u7684\u4e30\u5bcc\u6027\uff09\u548c\u4e34\u5e8a\u7ed3\u679c\u6709\u5173\u3002\u4f8b\u5982\uff0c\u5728\u80be\u764c\u4e2d\uff0c\u5bcc\u96c6CD8-Mo-cDC1\u539f\u578b\u7684\u75c5\u4eba\u6bd4CD4-cDC2\u6216Treg-Mp\u539f\u578b\u7684\u75c5\u4eba\u6709\u66f4\u597d\u7684\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Krummel\u7136\u540e\u5c55\u793a\u4e86\u4ed6\u7684\u5b9e\u9a8c\u5ba4\u5173\u4e8eCD206+<\/sup>\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u63a7\u5236\u4e2d\u7684\u4f5c\u7528\u7684\u4e00\u4e9b\u5de5\u4f5c\uff0c\u8bc1\u660e\u4e86\u5728\u4f53\u5185\u5de8\u566c\u7ec6\u80de\u5b9e\u9645\u4e0a\u5e76\u4e0d\u6291\u5236\uff08\u4e00\u4e2a\u5728\u4f53\u5916\u975e\u751f\u7406\u8868\u578b\uff09\uff0c\u800c\u662f\uff0c\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAMs\uff09\u8ba9T\u7ec6\u80de\u8017\u7aed\uff0c\u4e0d\u6fc0\u6d3b\u5b83\u4eec\u3002\u4ed6\u5f3a\u8c03\u4e86\u9700\u8981\u57fa\u4e8e\u5176\u529f\u80fd\u6765\u5206\u7c7b\u5de8\u566c\u7ec6\u80de\uff0c\u4ed6\u5c55\u793a\u4e86M1\u548cM2\u6807\u8bb0\u5e76\u4e0d\u80fd\u5728PyMT\u80bf\u7624\u6216\u4eba\u7c7b\u6837\u672c\u4e2d\u5bf9TAMs\u8fdb\u884c\u5206\u7c7b\u3002\u5728B16F10\u9ed1\u8272\u7d20\u7624\u80bf\u7624\u4e2d\uff0cCD206\uff0c\u88ab\u89c6\u4e3aM2\u6807\u8bb0\uff0c\u4e0e\u5355\u6838\u7ec6\u80de\u5230\u5de8\u566c\u7ec6\u80de\u7684\u5206\u5316\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u673a\u5236\u4e0a\uff0c\u4ece\u80bf\u7624\u690d\u5165\u540e\u65e9\u671f\u5f00\u59cb\u5728\u5c0f\u9f20\u4e2d\u6e05\u9664CD206+<\/sup>\u9ad3\u7cfb\u7ec6\u80de\u5bfc\u81f4\u53cd\u5e94\u6027\u514d\u75ab\u539f\u578b\u7684\u95f4\u63a5\u635f\u5931\uff08MACs\u3001cDC1\u3001NK\u7ec6\u80de\u548cOT1 CD8+ T\u7ec6\u80de\u7684\u51cf\u5c11\uff09\uff0c\u4f46\u665a\u671fTAM\u8017\u7aed\u5e76\u672a\u5bfc\u81f4\u8fd9\u79cd\u60c5\u51b5\u3002\u65e9\u671f\u8017\u7aed\u4e5f\u964d\u4f4e\u4e86B78chOVA\u80bf\u7624\u7684\u63a7\u5236\u5e76\u7834\u574f\u4e86CXCL9:CXCR3\u7684\u62db\u52df\u8f74\uff0c\u8fd9\u8868\u660eCD206+<\/sup> TAM:cDC1\u53cd\u5e94\u578b\u539f\u578b\u5bf9\u4e8e\u6297\u80bf\u7624\u514d\u75ab\u662f\u5fc5\u9700\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bf9\u6765\u81ea5\u4e2a\u6307\u793a\u7684230\u540d\u60a3\u8005\u7684CD206-\u4f4e\u548cCD206-\u9ad8\u57fa\u56e0\u96c6\u8fdb\u884c\u6bd4\u8f83\uff0c\u663e\u793a\u51faCD206\u8868\u8fbe\u8f83\u9ad8\u7684\u60a3\u8005\u6709\u751f\u5b58\u4f18\u52bf\u3002\u603b\u7684\u6765\u8bf4\uff0c\u65e9\u671f\u80bf\u7624\u9636\u6bb5\u7684CD206+<\/sup> TAMs\u901a\u8fc7CXCL9\/10\u8f74\u7ef4\u6301\u4e86\u91cd\u8981\u7684CD8\uff0cNK\u548ccDC1\u539f\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2. \u901a\u8fc7\u7ebf\u7c92\u4f53\u91cd\u7f16\u7a0b\u5f15\u5bfc\u7684\u8f6c\u5f55\u7f51\u7edc\u6765\u5b9a\u5236T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u514d\u75ab<\/strong><\/p>\n<\/section>\n

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Ping-Chih Ho – \u745e\u58eb\u6d1b\u6851\uff0c\u6d1b\u6851\u5927\u5b66<\/strong><\/p>\n<\/section>\n

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\u5728\u957f\u671f\u6297\u539f\u66b4\u9732\u4e0b\u53d1\u751f\u7684T\u7ec6\u80de\u8017\u7aed\uff0c\u662f\u7531\u4e0d\u53ef\u9006\u8f6c\u7684\u8868\u89c2\u9057\u4f20\u7f16\u7a0b\u9a71\u52a8\u7684\u3002\u5728\u8ba8\u8bba\u5982\u4f55\u4fdd\u6301T\u7ec6\u80de\u7684\u53cd\u5e94\u6027\u7b56\u7565\u65f6\uff0cPing-Chih Ho\u6307\u51fa\uff0c\u524d\u4f53\u8017\u7aed\u548c\u6548\u5e94T\u7ec6\u80de\u663e\u793a\u51fa\u4e0d\u540c\u7684\u7ebf\u7c92\u4f53\u5065\u5eb7\u72b6\u51b5\u3002\u7279\u522b\u5730\uff0c\u8017\u7aed\u4e0e\u7531\u4e8e\u964d\u4f4e\u7684\u7ebf\u7c92\u4f53\u81ea\u566c\uff08\u901a\u8fc7\u81ea\u566c\u964d\u89e3\u7ebf\u7c92\u4f53\uff09\u800c\u79ef\u7d2f\u7684\u53bb\u6781\u5316\/\u635f\u574f\u7684\u7ebf\u7c92\u4f53\u6709\u5173\uff0c\u5c3d\u7ba1\u4e0e\u86cb\u767d\u9176\u4f53\u76f8\u5173\u7684\u57fa\u56e0\u6c34\u5e73\u5f88\u9ad8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u66f4\u6df1\u5165\u7684\u89c2\u5bdf\uff0c\u7814\u7a76\u4eba\u5458\u5728\u529f\u80fd\u5931\u8c03\u7684\u7ebf\u7c92\u4f53\u4e2d\u770b\u5230\u4e86\u8017\u7aed\u7684CD8+ <\/sup>T\u7ec6\u80de\u4e2d\u7684\u9ad8\u6c34\u5e73\u7684\u8c03\u63a7\u6027\u8840\u7ea2\u7d20\uff08RH\uff1b\u7531\u7ebf\u7c92\u4f53\u8840\u7ea2\u86cb\u767d\u964d\u89e3\u91ca\u653e\u7684\u80de\u8d28\u8840\u7ea2\u7d20\uff09\u3002\u963b\u6b62\u86cb\u767d\u8d28\u964d\u89e3\u53ef\u4ee5\u6d88\u9664RH\u7684\u589e\u52a0\uff0c\u800c\u5728\u91cd\u590d\u523a\u6fc0\u7684\u6761\u4ef6\u4e0b\uff0c\u7528\u8840\u7ea2\u7d20\u7684\u7ed3\u6784\u7c7b\u4f3c\u7269Hemin\u57f9\u517b\u7ec6\u80de\uff0c\u5f15\u53d1\u4e86\u7ec8\u672b\u8017\u7aed\u7ec6\u80de\u7684\u7279\u5f81\uff0c\u5305\u62ec\u964d\u4f4e\u7684\u589e\u6b96\u548c\u53d7\u635f\u7684\u6548\u5e94\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3002\u5c06\u8fd9\u4e9b\u7ec6\u80de\u8f6c\u79fb\u5230\u5c0f\u9f20\u4e2d\uff0c\u7136\u540e\u611f\u67d3\u6025\u6027LCMV\uff08Armstong\uff09\u5bfc\u81f4\u5728\u4f53\u5185\u5177\u6709\u76f8\u4f3c\u8017\u7aed\u8868\u578b\u7684\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7814\u7a76\u8fd9\u80cc\u540e\u7684\u673a\u5236\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u8840\u7ea2\u7d20\u4e0eBach2\u8840\u7ea2\u86cb\u767d\u7ed3\u5408 – \u8fd9\u662f\u8c03\u8282T\u7ec6\u80de\u5206\u5316\u7684\u91cd\u8981\u7684\u6291\u5236\u6027\u8f6c\u5f55\u56e0\u5b50 – \u5bfc\u81f4BACH2\u964d\u89e3\u548cDNA\u7ed3\u5408\u7684\u51cf\u5c11\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u4e0d\u80fd\u7ed3\u5408\u8840\u7ea2\u7d20\u7684Bach2\u7684\u7a81\u53d8\u5f62\u5f0f\u80fd\u591f\u4fdd\u6301\u6291\u5236\u6027\u8f6c\u5f55\u6d3b\u6027\u3002\u8868\u8fbe\u7a81\u53d8Bach2\u7684\u7ec6\u80de\u6ca1\u6709\u663e\u793a\u51fa\u6d78\u6da6\u4f18\u52bf\uff0c\u4f46\u786e\u5b9e\u663e\u793a\u51fa\u4fdd\u6301\u524d\u4f53\u8868\u578b\u548c\u62b5\u6297\u8017\u7aed\u7684\u66f4\u9ad8\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e9b\u7ec6\u80de\u4e5f\u663e\u793a\u51faBlimp1\u7684\u4e0b\u8c03\uff0c\u8fd9\u662f\u4e00\u4e2a\u8fdb\u5c55\u5230\u7ec8\u672b\u8017\u7aed\u72b6\u6001\u9700\u8981\u7684\u8f6c\u5f55\u56e0\u5b50\u3002\u5728\u673a\u5236\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0BACH2\u4e5f\u7ed3\u5408\u5230Blimp1\u7684\u542f\u52a8\u5b50\u4ee5\u6291\u5236Blimp1\u7684\u4ea7\u751f\u3002\u5728\u6572\u9664Pgrmc2\uff08\u4e00\u79cd\u5e2e\u52a9\u80de\u8d28\u8840\u7ea2\u7d20\u8fd0\u8f93\u5230\u6838\u7684\u8840\u7ea2\u7d20\u4f34\u4fa3\uff09\u65f6\uff0c\u4e5f\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\uff0c\u8fd9\u963b\u6b62\u4e86\u7ec8\u672b\u5206\u5316\u5e76\u589e\u5f3a\u4e86TILs\u7684\u591a\u529f\u80fd\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7ed3\u679c\u63ed\u793a\u4e86\u7ebf\u7c92\u4f53\u964d\u89e3\u662fT\u7ec6\u80de\u8017\u7aed\u7684\u5173\u952e\u51b3\u5b9a\u56e0\u7d20\uff0c\u5e76\u6307\u51fa\u4e86\u51e0\u4e2a\u53ef\u80fd\u7684\u76ee\u6807\uff0c\u8fd9\u4e9b\u76ee\u6807\u53ef\u4ee5\u5728\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e2d\u9650\u5236T\u7ec6\u80de\u7684\u8017\u7aed\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3. \u901a\u8fc7\u65f6\u95f4\u5355\u7ec6\u80de\u5206\u6790\u8bc6\u522bB\u7ec6\u80de\u7279\u5f02\u6027\u68c0\u67e5\u70b9\u5206\u5b50\u4ee5\u8c03\u63a7\u6297\u80bf\u7624\u514d\u75ab<\/strong><\/p>\n<\/section>\n

\n

Lloyd Bod – \u9a6c\u8428\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f\uff0c\u9a6c\u8428\u8bf8\u585e\u5dde\u603b\u533b\u9662<\/strong>
<\/p>\n<\/section>\n

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B\u7ec6\u80de\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7ecf\u5e38\u88ab\u5ffd\u89c6\uff0c\u4f46Lloyd Bod\u5728\u7406\u89e3\u5b83\u4eec\u6297\u80bf\u7624\u548c\u4fc3\u80bf\u7624\u529f\u80fd\u4e4b\u95f4\u7684\u5e73\u8861\u65b9\u9762\u53d6\u5f97\u4e86\u8fdb\u5c55\u3002\u4f8b\u5982\uff0c\u867d\u7136B\u7ec6\u80de\u53ef\u4ee5\u5728\u6297\u539f\u5448\u73b0\u3001\u5171\u523a\u6fc0\u3001\u4f53\u6db2\u53cd\u5e94\u3001\u708e\u75c7\u6027\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u4ee5\u53ca\u5f62\u6210\u4e09\u7ea7\u6dcb\u5df4\u7ed3\u6784\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u4f46\u5b83\u4eec\u4e5f\u53ef\u4ee5\u4ea7\u751f\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\uff0c\u76f4\u63a5\u6291\u5236T\u7ec6\u80de\uff0c\u5e76\u4fc3\u8fdbIg\u514d\u75ab\u590d\u5408\u7269\u7684\u5f62\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u5728\u80bf\u7624\u4e2d\u7684\u6d78\u6da6\u4ee5\u53ca\u7ed3\u679c\u4e4b\u95f4\u7684\u5173\u7cfb\u5728\u4e0d\u540c\u7684\u80bf\u7624\u548c\u7814\u7a76\u4e2d\u4e5f\u6709\u6240\u4e0d\u540c\u3002\u4e3a\u4e86\u786e\u5b9a\u662f\u5426\u67d0\u4e9bB\u7ec6\u80de\u4e9a\u7fa4\u53ef\u80fd\u663e\u793a\u66f4\u660e\u786e\u7684\u53cd\u5e94\u6216\u65e0\u53cd\u5e94\u7684\u76f8\u5173\u6027\uff0cBod\u4ece\u643a\u5e26B16F10\u9ed1\u8272\u7d20\u7624\u7684\u5c0f\u9f20\u7684\u80bf\u7624\u3001\u5f15\u6d41\u6dcb\u5df4\u7ed3\u548c\u975e\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u5206\u79bb\u5e76\u8868\u5f81\u4e86B\u7ec6\u80de\u3002\u8fd9\u63ed\u793a\u4e86\u4e00\u4e2a\u8868\u8fbeTIM-1\u7684B\u7ec6\u80de\u7fa4\uff0c\u5b83\u4eec\u5728\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u968f\u65f6\u95f4\u589e\u52a0\u3002\u5bf9\u8fd9\u4e9bTIM-1+ <\/sup>B\u7ec6\u80de\u7684\u8fdb\u4e00\u6b65\u8868\u5f81\u663e\u793a\uff0c\u5b83\u4eec\u8868\u8fbe\u4e86\u5927\u91cf\u6291\u5236\u6027\u68c0\u67e5\u70b9\u5206\u5b50\u3002\u5728\u4eba\u7c7b\u9ed1\u8272\u7d20\u7624\u548c\u5176\u4ed6\u764c\u75c7\u7684\u6837\u672c\u4e2d\u4e5f\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7814\u7a76\u8fd9\u4e9bB\u7ec6\u80de\u4e0a\u7684\u6291\u5236\u6027\u53d7\u4f53\u7684\u4f5c\u7528\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4e00\u4e2a\u4f53\u5185\u529f\u80fd\u7b5b\u9009\uff0c\u5176\u4e2d\u4e0d\u540c\u7684\u6291\u5236\u53d7\u4f53\u88ab\u6572\u9664\u3002\u867d\u7136\u5728B\u7ec6\u80de\u4e2d\u5220\u9664TIM-3\u3001TIGIT\u3001PD-1\u3001LAG-3\u6216IL-10\u5bf9\u80bf\u7624\u751f\u957f\u51e0\u4e4e\u6ca1\u6709\u5f71\u54cd\uff0c\u4f46\u5728B\u7ec6\u80de\u4e2d\u5220\u9664TIM-1\u663e\u8457\u6291\u5236\u4e86\u80bf\u7624\u751f\u957f\u3002\u673a\u5236\u7814\u7a76\u8fdb\u4e00\u6b65\u8868\u660e\uff0cTIM-1\u7684\u5220\u9664\u589e\u5f3a\u4e86\u5bf9IFN\u03b3\u7684\u654f\u611f\u6027\uff0c\u5bfc\u81f4B\u7ec6\u80de\u7684\u6297\u539f\u5448\u9012\u6d3b\u6027\u589e\u5f3a\uff0c\u4f46\u5e76\u4e0d\u589e\u52a0\u4f53\u6db2\u514d\u75ab\u3002\u6b64\u5916\uff0c\u8fd9\u79cd\u589e\u5f3a\u7684B\u7ec6\u80de\u6fc0\u6d3b\u53ef\u4ee5\u4fc3\u8fdbT\u7ec6\u80de\u5411\u6548\u5e94\u548c\u7ec6\u80de\u6bd2\u6027\uff0c\u800c\u4e0d\u662f\u8c03\u8282\u6027\u8868\u578b\u8f6c\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7ed3\u679c\u786e\u5b9a\u4e86TIM-1\u662f\u4e00\u4e2a\u91cd\u8981\u7684B\u7ec6\u80de\u68c0\u67e5\u70b9\u548c\u53ef\u80fd\u7684\u514d\u75ab\u6cbb\u7597\u76ee\u6807\uff0c\u4ee5\u589e\u5f3aB\u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u652f\u6301\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4. \u901a\u8fc7\u7a7a\u95f4\u529f\u80fd\u57fa\u56e0\u7ec4\u5b66\u8bc6\u522b\u80bf\u7624\u514d\u75ab\u7684\u8c03\u63a7\u56e0\u5b50<\/strong><\/p>\n<\/section>\n

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Brian D. Brown – \u7ebd\u7ea6\u5e02\u897f\u5948\u5c71\u4f0a\u574e\u533b\u5b66\u9662<\/strong><\/p>\n<\/section>\n

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Brian Brown\u7684\u6f14\u8bb2\u4e3b\u8981\u5173\u6ce8\u7684\u662f\u9a71\u52a8\u5f02\u8d28\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5404\u79cd\u7ec4\u7ec7\u7ed3\u6784\u548c\u6761\u4ef6\u7684\u56e0\u7d20\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3\u764c\u75c7\u5982\u4f55\u63a7\u5236TME\uff0cBrown\u548c\u540c\u4e8b\u4eec\u8fdb\u884c\u4e86\u53d7\u4f53\/\u914d\u4f53\u914d\u5bf9\u5206\u6790\uff0c\u8fd9\u4e2a\u5206\u6790\u8bc6\u522b\u51fa35-50\u79cd\u8c03\u63a7\u5de8\u566c\u7ec6\u80de\u7684\u56e0\u7d20\uff0c\u7279\u522b\u662f\u5728\u5375\u5de2\u764c\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9274\u4e8eCRISPR\u7b5b\u9009\u9650\u4e8e\u7ec6\u80de\u81ea\u4e3b\u6548\u5e94\uff0c\u4ee5\u53ca\u529f\u80fd\u57fa\u56e0\u7ec4\u5b66\u65b9\u6cd5\u4e0d\u80fd\u8bc6\u522b\u7ec6\u80de\u5916\u8868\u578b\uff08\u5982\u7ec6\u80de\u62db\u52df\uff09\u6216\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u7684\u529f\u80fd\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u4e2apro-Code\/CRISPR\u5e93\uff0c\u8be5\u5e93\u5c06\u76ee\u6807\u5b9a\u4f4d\u523035\u4e2a\u53d7\u4f53\u548c\u914d\u4f53\u5728ID8\u5375\u5de2\u764c\u4e2d\u7684\u6572\u9664\uff0c\u5e76\u5141\u8bb8\u5728\u4f53\u5916\u6216\u4f53\u5185\u7684\u6761\u5f62\u7f16\u7801\u86cb\u767d\u8d28\u6c34\u5e73\u4e0a\u8bfb\u51faCRISPR\u7b5b\u9009\u7ed3\u679c\u3002\u867d\u7136\u6ca1\u6709\u4e00\u4e2a\u6572\u9664\u5f71\u54cd\u5230\u764c\u7ec6\u80de\u7684\u9002\u5e94\u6027\uff0c\u4f46\u5728\u4f53\u5185\u7684\u57fa\u56e0\u6572\u9664\u590d\u5236\u4e86\u80bf\u7624\u5185\u514b\u9686\u7684\u5f02\u8d28\u6027\u3002\u53d1\u73b0Ccl7\u3001Ccl3\u548cCalr\u7684\u7f3a\u5931\u4f1a\u589e\u52a0\u80bf\u7624\u8d1f\u62c5\uff0c\u800cPaur\u3001Mif\u3001Serpine1\u548cThbs1\u7684\u7f3a\u5931\u5219\u4e0e\u51cf\u5c11\u7684\u80bf\u7624\u8d1f\u62c5\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7814\u7a76CCL7\u7f3a\u5931\u5bf9\u80bf\u7624\u751f\u957f\u7684\u652f\u6301\u4f5c\u7528\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u5373\u4f7f\u5728CCL7\u88ab\u6572\u9664\u65f6\uff0c\u80bf\u7624\u7ec6\u80de\u5728\u6df7\u5408\u80bf\u7624\u73af\u5883\u4e2d\u4ecd\u80fd\u8d85\u8d8a\u4eb2\u672c\u7ec6\u80de\u7684\u751f\u957f\u3002CCL7\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u6572\u9664\u8fd8\u4fc3\u8fdb\u4e86\u80bf\u7624\u5185\u90e8\u7684\u5f02\u8d28\u6027\uff0c\u4e00\u4e2a\u514d\u75ab\u6392\u9664\u7684TME\u548c\u514b\u9686\u9009\u62e9\uff0c\u8fd9\u8868\u660eCCL7\u662f\u514d\u75abTME\u7684\u4e3b\u8981\u8c03\u63a7\u56e0\u5b50\u3002\u5728\u4eba\u7c7b\u5375\u5de2\u80bf\u7624\u4e2d\uff0cCCL7\u4e0e\u66f4\u597d\u7684\u9884\u540e\u548c\u514d\u75ab\u6d78\u6da6\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u5bfb\u627e\u5f71\u54cd\u5375\u5de2\u764c\u5bf9\u6297PD-1\u6297\u6027\u7684\u57fa\u56e0\u7684\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5728\u7531\u524d\u8ff0CRISPR\u5e93\u9a71\u52a8\u7684\u5f02\u8d28\u6027\u80bf\u7624\u7684\u5c0f\u9f20\u4e2d\uff0cIL-4\u7684\u7f3a\u5931\u4f7f\u80bf\u7624\u5bf9\u6297PD-1\u66f4\u654f\u611f\uff0c\u8fd9\u8868\u660eIL-4\u4fc3\u8fdb\u4e86\u5bf9\u6cbb\u7597\u7684\u6297\u6027\u3002\u6b64\u5916\uff0c\u53d1\u73b0IL-4\u7531\u5c0f\u9f20\u548c\u4eba\u5375\u5de2\u764c\u7ec6\u80de\u4ea7\u751f\uff0c\u5e76\u901a\u8fc7\u5375\u5de2\u80bf\u7624\u5de8\u566c\u7ec6\u80de\u4e2d\u7684IL-4\u8bf1\u5bfc\u4fe1\u53f7\u4f20\u5bfc\u4fc3\u8fdb\u4e86\u5bf9\u6297PD-1\u7684\u6297\u6027\uff0c\u8fd9\u5bfc\u81f4\u4e86TME\u4e2d\u5de8\u566c\u7ec6\u80de\u7684\u5bcc\u96c6\u548cT\u7ec6\u80de\u7684\u51cf\u5c11\uff0c\u4ee5\u53caTLS\u6837\u6dcb\u5df4\u805a\u96c6\u4f53\u5f62\u6210\u7684\u51cf\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u2014 THE  END \u2014<\/span><\/section>\n
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ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

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RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

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