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\u5171\u523a\u6fc0\u5206\u5b50\u672c\u8eab\u4e0d\u5177\u5907\u9176\u6d3b\u6027\uff0c\u5176\u529f\u80fd\u4f9d\u8d56\u4e8e\u5bf9\u4fe1\u53f7\u9002\u914d\u86cb\u767d\u7684\u52a8\u6001\u62db\u52df\u3002\u5206\u6790\u5171\u523a\u6fc0\u53d7\u4f53\u53d1\u51fa\u7684\u7ec6\u80de\u5185\u4fe1\u53f7\u662f\u4e00\u9879\u6311\u6218\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u4fe1\u53f7\u5f80\u5f80\u5728\u5f3a\u5927\u7684TCR-CD3\u523a\u6fc0\u80cc\u666f\u4e0b\u4ea7\u751f\u3002\u7814\u7a76\u901a\u5e38\u8868\u660e\uff0c\u5171\u523a\u6fc0\u53d7\u4f53\u7684\u603b\u4f53\u4f5c\u7528\u4e3b\u8981\u662f\u5bf9TCR\u4f9d\u8d56\u7684\u4fe1\u53f7\u8fdb\u884c\u653e\u5927\u6216\u589e\u5f3a\uff0c\u5e76\u5f88\u5c11\u6709\u8bc1\u636e\u663e\u793a\u5b83\u4eec\u80fd\u591f\u72ec\u7acb\u89e6\u53d1\u751f\u5316\u7684\u7b2c\u4e8c\u4fe1\u53f7\u4f20\u9012\u3002\u8fd9\u7c7b\u5171\u523a\u6fc0\u53d7\u4f53\u7684\u4e0b\u6e38\u76f4\u63a5\u751f\u5316\u4e8b\u4ef6\u4e3b\u8981\u5305\u62ec\u916a\u6c28\u9178\u548c\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6b8b\u57fa\u7684\u78f7\u9178\u5316\uff0c\u6216\u662f\u86cb\u767d\u8d28\u53d1\u751f\u6cdb\u7d20\u5316\u3002\u8fd9\u4e24\u79cd\u6539\u53d8\u90fd\u80fd\u5f15\u53d1\u77ac\u6001\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u4f4d\u70b9\u7684\u4ea7\u751f\u548c\u591a\u86cb\u767d\u590d\u5408\u4f53\u7684\u5f62\u6210\uff0c\u8fd9\u901a\u5e38\u4f1a\u5bfc\u81f4\u8f6c\u5f55\u56e0\u5b50\u7684\u6fc0\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5171\u523a\u6fc0\u5206\u5b50\u7684\u4fe1\u53f7\u4f20\u9012\u901a\u5e38\u7531\u5176\u5929\u7136\u914d\u4f53\u6fc0\u6d3b\uff0c\u4e0d\u8fc7\u4e5f\u53ef\u4ee5\u901a\u8fc7\u4e8c\u4ef7\u6297\u4f53\u6216\u914d\u4f53\u3001\u5355\u514b\u9686\u6297\u4f53\uff08mAbs\uff09\uff0c\u6216\u5176\u4ed6\u5206\u5b50\u5982\u6838\u82f7\u9178\u9002\u914d\u4f53\u7684\u4ea4\u8054\u4f5c\u7528\u6765\u589e\u5f3a\u3002\u8fd9\u4e9b\u4fe1\u53f7\u4f20\u9012\u8fc7\u7a0b\u4e00\u822c\u5728\u514d\u75ab\u7a81\u89e6\u7684\u7279\u5b9a\u533a\u57df\u5185\u53d1\u751f\uff0c\u5e76\u4e14\u5728\u53d7\u4f53\u4e0e\u914d\u4f53\u7ed3\u5408\u540e\uff0c\u53d7\u4f53\u5f80\u5f80\u4f1a\u88ab\u5185\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\uff08TNFR\uff09\u5bb6\u65cf\u7531\u5177\u5907\u4e0d\u540c\u7ed3\u6784\u548c\u529f\u80fd\u7684\u5206\u5b50\u7ec4\u6210\uff0c\u5206\u4e3a\u5305\u542b\u80de\u6d46\u5185\u6b7b\u4ea1\u7ed3\u6784\u57df\u7684\u6210\u5458\u4ee5\u53ca\u4e0d\u542b\u6b64\u7ed3\u6784\u57df\u7684\u6210\u5458\u3002\u8fd9\u4e2a\u5bb6\u65cf\u5728\u514d\u75ab\u7cfb\u7edf\u4e2d\u8d1f\u8d23\u8c03\u63a7\u591a\u79cd\u673a\u80fd\uff0c\u5305\u62ec\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3001\u53c2\u4e0e\u708e\u75c7\u53cd\u5e94\u4ee5\u53ca\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u3002\u5728\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u4e2d\uff0c\u7279\u522b\u5173\u6ce8\u7684\u662f\u90a3\u4e9b\u4e0d\u542b\u6b7b\u4ea1\u7ed3\u6784\u57df\u7684\u9776\u5411\u53d7\u4f53\uff0c\u56e0\u4e3a\u542b\u6709\u6b7b\u4ea1\u7ed3\u6784\u57df\u7684\u53d7\u4f53\u4f1a\u5f15\u5165caspase\u6fc0\u6d3b\u673a\u5236\u3002TNFR\u81ea\u8eab\u4e0d\u5177\u6709\u4efb\u4f55\u5185\u5728\u9176\u6d3b\u6027\uff0c\u5b83\u4eec\u7684\u4fe1\u53f7\u4f20\u5bfc\u4f5c\u7528\u4f9d\u8d56\u4e8e\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u76f8\u5173\u56e0\u5b50\uff08TRAF\uff09\u5bb6\u65cf\u4ee5\u53ca\u5176\u4ed6\u9002\u914d\u86cb\u767d\u7684\u534f\u52a9\u3002\u56fe26.1\u901a\u8fc7\u793a\u610f\u56fe\u5c55\u793a\u4e86TNFR\u5bb6\u65cf\u6210\u5458\u53ca\u5176\u914d\u4f53\u5728\u514d\u75ab\u7a81\u89e6\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u4e14\u4ecb\u7ecd\u4e86\u6b63\u5728\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u6fc0\u52a8\u5242\u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 26.1 <\/span>\u5728T\u7ec6\u80de\u3001NK\u7ec6\u80de\u548c\u6297\u539f\u5448\u9012\u7ec6\u80de(apc)\u4e0a\u8868\u8fbe\u7684TNF\u548cTNFR\u5bb6\u65cf\u7684\u7ec4\u6210\u578b\u548c\u6fc0\u6d3b\u8bf1\u5bfc\u7684\u5171\u523a\u6fc0\u6210\u5458\u3002\u6548\u5e94T\u7ec6\u80de(Teff)\u3001\u8c03\u8282\u6027T\u7ec6\u80de(Treg)\u548c\u5177\u6709APC\u529f\u80fd\u7684NK\u7ec6\u80de\u4e4b\u95f4\u7684\u514d\u75ab\u7a81\u89e6\u793a\u610f\u56fe\u3002\u4e3a\u6bcf\u4e2aTNFR\u5171\u523a\u6fc0\u5206\u5b50\u63d0\u4f9b\u4e86TRAF\u63a5\u5934\u7684\u4f7f\u7528\u548c\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u6fc0\u52a8\u5242\u5355\u514b\u9686\u6297\u4f53\u7684\u53c2\u8003<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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26.2 TNFR\u5bb6\u65cf\u5171\u523a\u6fc0\u53d7\u4f53\u6297\u4f53\u6fc0\u52a8\u5242\u7684\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7ecf\u9a8c<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u836f\u7406\u5b66\u9886\u57df\uff0c\u6709\u610f\u8bc6\u5730\u4ee5\u6297\u539f\u7279\u5f02\u6027\u7684\u65b9\u5f0f\u542f\u52a8\u6216\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u4e00\u76f4\u662f\u4e00\u4e2a\u957f\u671f\u8ffd\u6c42\u4f46\u96be\u4ee5\u8fbe\u6210\u7684\u76ee\u6807\u3002\u867d\u7136\u75ab\u82d7\u63a5\u79cd\u5728\u9884\u9632\u9886\u57df\u53d6\u5f97\u4e86\u6210\u529f\u2014\u2014\u5373\u5728\u63a5\u89e6\u4f20\u67d3\u6027\u75c5\u539f\u4f53\u6216\u6bd2\u7d20\u4e4b\u524d\u8bf1\u5bfc\u51fa\u4e2d\u548c\u6297\u4f53\u2014\u2014\u4f46\u662f\u5728\u8bf1\u5bfc\u4fdd\u62a4\u6027\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u65b9\u9762\uff0c\u75ab\u82d7\u7684\u6548\u679c\u901a\u5e38\u662f\u6709\u9650\u7684\u3002\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\uff0c\u5e38\u89c1\u7684\u73b0\u8c61\u662f\u5df2\u7ecf\u5b58\u5728\u4e00\u5b9a\u7a0b\u5ea6\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u867d\u7136\u8fd9\u4e9b\u53cd\u5e94\u5f3a\u5ea6\u4e0d\u8db3\u4ee5\u6d88\u9664\u6076\u6027\u80bf\u7624\uff0c\u4f46\u4ece\u591a\u9879\u5c0f\u9f20\u548c\u4eba\u7c7b\u7814\u7a76\u4e2d\u6211\u4eec\u5f97\u77e5\uff0c\u8fd9\u4e9b\u514d\u75ab\u53cd\u5e94\u5b9e\u9645\u4e0a\u5728\u79ef\u6781\u5730\u9650\u5236\u80bf\u7624\u7684\u8fdb\u5c55\u3002\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\uff0c\u514d\u75ab\u7cfb\u7edf\u4e0e\u764c\u75c7\u4e4b\u95f4\u7ef4\u6301\u7740\u4e00\u79cd\u52a8\u6001\u5e73\u8861\uff0c\u4e3b\u8981\u5728\u80bf\u7624\u7684\u5fae\u73af\u5883\u53ca\u53ef\u80fd\u5728\u80bf\u7624\u5f15\u6d41\u7684\u6dcb\u5df4\u7ed3\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u57fa\u4e8e\u8fd9\u4e9b\u89c2\u70b9\uff0c\u53ef\u4ee5\u8bbe\u60f3\u901a\u8fc7\u5bf9\u8fd9\u79cd\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u53d7\u4f53\u65bd\u4ee5\u836f\u7406\u5f71\u54cd\uff0c\u51b3\u5b9a\u6027\u5730\u589e\u5f3a\u6f5c\u5728\u7684\u57fa\u7ebf\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u4f7f\u5176\u5177\u5907\u5bf9\u6297\u6076\u6027\u80bf\u7624\u7684\u80fd\u529b\u300220\u4e16\u7eaa90\u5e74\u4ee3\u672b\u7684\u514d\u75ab\u5b66\u7814\u7a76\u610f\u5916\u53d1\u73b0\uff0c\u901a\u8fc7\u523a\u6fc0TNFR\u5bb6\u65cf\u6210\u5458\u53ef\u4ee5\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u5b9e\u73b0\u80bf\u7624\u7684\u6839\u9664\u3002\u76ee\u524d\uff0c\u5173\u4e8e\u9776\u5411\u8be5\u5bb6\u65cf\u5173\u952e\u53d7\u4f53\u7684\u77e5\u8bc6\u548c\u5176\u4e34\u5e8a\u7814\u7a76\u6548\u679c\u6b63\u5728\u4e0d\u65ad\u79ef\u7d2f\u4e4b\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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26.3 TNF\u5bb6\u65cf\u6210\u5458CD137 (4-1BB)<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CD137\uff08\u4ea6\u79f0\u4e3a4-1BB\u6216TNFRSF9\uff09\u6700\u521d\u5728\u6d3b\u5316\u7684T\u6dcb\u5df4\u7ec6\u80de\u4e0a\u88ab\u8bc6\u522b\u5230\uff0c\u5e76\u5df2\u88ab\u8bc1\u5b9e\u80fd\u4fc3\u8fdbT\u7ec6\u80de\u7684\u589e\u6b96\u548cIL-2\u7684\u4ea7\u751f\u3002\u5b9e\u9645\u4e0a\uff0c\u5728\u6297\u539f\u8bf1\u5bfc\u7684\u6fc0\u6d3b\u4e4b\u540e\uff0cCD137\u7684\u8868\u8fbe\u5728\u6d3b\u5316\u7684CD8+\u548cCD4+T\u7ec6\u80de\uff08\u5305\u62ec\u8c03\u8282\u6027T\u7ec6\u80de\uff0cTreg\uff09\u4e0a\u5bb9\u6613\u88ab\u68c0\u6d4b\u5230\u3002\u7814\u7a76\u8fd8\u53d1\u73b0\u5b83\u5728\u6d3b\u5316\u7684NK\u7ec6\u80de\u3001B\u7ec6\u80de\u548c\u9ad3\u7cfb\u7ec6\u80de\u4e0a\u4e5f\u6709\u8868\u8fbe\u3002\u5728\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u7684\u5b9e\u9a8c\u4e2d\uff0cCD137\u88ab\u8bc1\u660e\u5bf9\u4e8e\u4ea7\u751f\u7406\u60f3\u7684\u6297\u75c5\u6bd2\u548c\u540c\u79cd\u5f02\u4f53\u53cd\u5e94\u7684CTL\uff08\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff09\u53cd\u5e94\u4ee5\u53ca\u75c5\u6bd2\u611f\u67d3\u540e\u957f\u6548\u8bb0\u5fc6T\u7ec6\u80de\u7684\u8bf1\u5bfc\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u5df2\u786e\u8ba4CD137\u7684\u552f\u4e00\u8de8\u819c\u914d\u4f53\u662fCD137L\uff0c\u5c5e\u4e8eTNF\u5bb6\u65cf\uff0c\u4e5f\u79f0\u4e3a4-1BBL\u6216TNFSF9\u3002\u8fd9\u4e00\u914d\u4f53\u4e0e\u53d7\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u4e2d\u663e\u793a\u51fa\u663e\u8457\u7684\u4fdd\u5b88\u6027\u3002\u914d\u4f53\u7684\u7ed3\u5408\u6fc0\u53d1CD137\u901a\u8fc7\u4e0eTRAF2\u548cTRAF1\u7ed3\u5408\u4f5c\u4e3a\u4e3b\u8981\u9002\u914d\u5206\u5b50\uff0c\u53d1\u51fa\u5f3a\u6709\u529b\u7684\u4fe1\u53f7\u3002\u5df2\u53d1\u73b0CD137\u914d\u4f53\u7684\u80de\u5916\u533a\u80fd\u591f\u901a\u8fc7\u4e0e\u5176\u7cd6\u57fa\u5316\u72b6\u6001\u76f8\u5173\u7684Galectin 9\u53d1\u751f\u4e00\u5b9a\u7a0b\u5ea6\u7684\u9884\u4ea4\u8054\u4f5c\u7528\u3002\u8fd9\u79cd\u7531\u51dd\u96c6\u7d20\u9884\u4ea4\u8054\u7684CD137\u590d\u5408\u4f53\u7684\u6784\u8c61\u53ef\u80fd\u5bf9\u4e8e\u4fe1\u53f7\u4f20\u5bfc\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CD137\u7684\u521d\u59cb\u4fe1\u53f7\u4f20\u5bfc\u6d89\u53caTRAF2\u4f9d\u8d56\u7684K-63\u94fe\u578b\u6cdb\u7d20\u5316\u4f5c\u7528\uff0c\u6700\u7ec8\u89e6\u53d1NF-\u03baB\u548cMAP\u6fc0\u9176\u9014\u5f84\u7684\u6d3b\u5316\u3002\u65e9\u671f\u8bc1\u636e\u663e\u793a\uff0c\u8fd9\u4e9b\u9014\u5f84\u53d7\u5230\u7279\u5b9a\u53bb\u6cdb\u7d20\u5316\u9176\u7684\u79ef\u6781\u8c03\u63a7\u3002\u867d\u7136TRAF1\u5728\u8fd9\u4e9b\u590d\u5408\u4f53\u4e2d\u7684\u786e\u5207\u751f\u5316\u529f\u80fd\u5c1a\u4e0d\u660e\u786e\uff0c\u4f46\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0cTRAF1\u53ef\u80fd\u53c2\u4e0e\u8c03\u8282\u5176\u4ed6TNF\u5bb6\u65cf\u53d7\u4f53\u7684\u7ebf\u6027\u6cdb\u7d20\u5316\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u5b58\u5728CD137\u6fc0\u52a8\u5242\u65f6\uff0c\u6d3b\u5316\u7684CD8+ T\u7ec6\u80de\u66f4\u6613\u4e8e\u4e0e\u6297\u539f\u53d1\u751f\u76f8\u9047\uff0c\u8fd9\u53ef\u80fd\u4e0emiRNA\u8868\u8fbe\u6a21\u5f0f\u7684\u53d8\u5316\u548c\u8868\u89c2\u9057\u4f20\u5c42\u9762\u7684\u67d3\u8272\u8d28\u7ed3\u6784\u8c03\u6574\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
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\n
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\n

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\n
\n
\n

CD137\u5171\u523a\u6fc0\u7684\u53e6\u4e00\u65b9\u9762\uff0c\u503c\u5f97\u5173\u6ce8\u7684\u662f\u5176\u4e0eT\u7ec6\u80de\u4e0aTCR\u4fe1\u53f7\u901a\u8def\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u5b83\u5728\u514d\u75ab\u7a81\u89e6\u4e2d\u7684\u884c\u4e3a\u3002\u8fd1\u671f\u7684\u7814\u7a76\u63d0\u793aCD137\u80fd\u5728\u4e0e\u5176\u914d\u4f53\u7ed3\u5408\u540e\u8fc5\u901f\u88ab\u5185\u5316\uff0c\u5c3d\u7ba1\u5982\u6b64\uff0c\u5b83\u4f3c\u4e4e\u80fd\u6301\u7eed\u4ece\u5185\u4f53\u4e2d\u4f20\u9012\u4fe1\u53f7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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PFZ-05082566\uff08Utomilumab\uff09\u662f\u4e00\u79cdIgG2\u7c7b\u578b\u7684\u6297CD137\u5355\u514b\u9686\u6297\u4f53\uff0c\u5b83\u5728\u4f53\u5916\u8bd5\u9a8c\u4e2d\u5c55\u793a\u4e86\u751f\u7269\u6d3b\u6027\uff0c\u5728\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u5b89\u5168\u6027\u7814\u7a76\u4e2d\u4e5f\u8868\u73b0\u826f\u597d\u3002\u8be5\u6297\u4f53\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u968f\u540e\u7684\u6269\u5c55\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u542b\u4e86\u4e0e\u5229\u59a5\u6614\u5355\u6297\uff08NCT01307267\uff09\u548c\u5f6d\u535a\u5229\u5355\u6297\uff08NCT02179918\uff09\u8054\u5408\u4f7f\u7528\u7684\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\u3002\u5728I\u671f\u8bd5\u9a8c\u4e2d\uff0c\u4e00\u4e9b\u6885\u514b\u5c14\u7ec6\u80de\u764c\u60a3\u8005\u6b63\u5728\u63a5\u53d7\u6cbb\u7597\uff0c\u521d\u6b65\u7ed3\u679c\u663e\u793a\u8be5\u6297\u4f53\u5177\u6709\u5ba2\u89c2\u7684\u4e34\u5e8a\u6d3b\u6027\uff0c\u800c\u5728\u8fc4\u4eca\u4e3a\u6b62\u7684\u5242\u91cf\u6c34\u5e73\u4e0a\u5e76\u672a\u89c2\u5bdf\u5230\u809d\u6bd2\u6027\u7684\u8ff9\u8c61\u3002\u4e34\u5e8a\u7f13\u89e3\u6570\u636e\u8868\u660e\uff0c\u4e0epembrolizumab\u8054\u5408\u4f7f\u7528\u65f6\uff0cUtomilumab\u81f3\u5c11\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u589e\u5f3a\u4e86\u6cbb\u7597\u6548\u679c\uff08ASCO 2016\uff09\u3002\u56e0\u6b64\uff0c\u6269\u5927\u7814\u7a76\u8303\u56f4\u4ee5\u63a2\u7d22\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u7684\u5fc5\u8981\u6027\u53d8\u5f97\u65e5\u76ca\u660e\u663e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Ignacio Melero, Elisabeth P\u00e9rez-Ruiz, Alfonso R. Sanchez-Paulete, Alvaro Teijeira, Angela Aznar, and Miguel F. Sanmamed<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u51bc\u91d1\u6b22<\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u675c\u8f7b\u677e<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764 \u80e1\u73ca<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

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RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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