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OX40\u6fc0\u52a8\u5242\u7684\u4e34\u5e8a\u5f00\u53d1\u59cb\u4e8e2006\u5e74\uff0c\u8d77\u521d\u4f7f\u7528\u7684\u662f\u9488\u5bf9\u4ebaOX40\u7684\u9f20\u6e90\u5355\u514b\u9686\u6297\u4f53\uff08AntihOX40\uff09\u3002\u8fd9\u79cd\u6297\u4f53\u6700\u521d\u5728\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e0a\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u6210\u529f\u540e\uff0c\u8fdb\u884c\u4e86\u9996\u6b21\u4eba\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728\u8fd9\u9879\u8bd5\u9a8c\u4e2d\uff0c30\u540d\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\u63a5\u53d7\u4e86\u4e09\u6b21\u5242\u91cf\u6cbb\u7597\uff08\u5206\u522b\u5728\u7b2c1\u30013\u548c5\u5929\uff09\uff0c\u5242\u91cf\u4ece0.1\u52302 mg\/kg\u4e0d\u7b49\u3002\u6cbb\u7597\u6574\u4f53\u4e0a\u88ab\u826f\u597d\u8010\u53d7\uff0c\u4e14\u672a\u8fbe\u5230\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002\u867d\u7136\u90e8\u5206\u60a3\u8005\u7684\u80bf\u7624\u4f53\u79ef\u6709\u6240\u51cf\u5c11\uff0c\u4f46\u6309\u7167RECIST\u6807\u51c6\u8bc4\u4f30\uff0c\u6ca1\u6709\u60a3\u8005\u663e\u793a\u51fa\u660e\u663e\u7684\u5ba2\u89c2\u54cd\u5e94\u3002<\/p>\n

\u6b64\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e00\u4e2a\u5173\u952e\u9650\u5236\u662f\u4e2d\u548c\u6027\u7684\u4eba\u6297\u9f20\u514d\u75ab\u7403\u86cb\u767d\u6297\u4f53\u6c34\u5e73\u6709\u6240\u589e\u9ad8\u3002\u5c3d\u7ba1\u5b58\u5728\u8fd9\u4e00\u6311\u6218\uff0c\u9488\u5bf9hOX40\u7684\u9f20\u6e90\u6297\u4f53\u4ecd\u7136\u5728\u4e0e\u5316\u7597\u548c\/\u6216\u653e\u7597\u8054\u5408\u7684\u5f62\u5f0f\uff0c\u7ee7\u7eed\u5728\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u4e2d\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u63a5\u4e0b\u6765\u7684\u91cd\u8981\u6b65\u9aa4\u662f\u5f00\u53d1\u5b8c\u5168\u4eba\u5316\u7684OX40\u6fc0\u52a8\u5242\uff0c\u8fd9\u5c06\u5141\u8bb8\u764c\u75c7\u60a3\u8005\u53ef\u4ee5\u8fdb\u884c\u591a\u6b21\u91cd\u590d\u6cbb\u7597\u3002\u4eba\u7c7bFc-OX40L\u878d\u5408\u86cb\u767d\u5df2\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u6709\u524d\u666f\u7684\u6548\u679c\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u5c06\u5728\u8fd1\u671f\u5185\u542f\u52a8\u3002<\/p>\n

\u76ee\u524d\uff0c\u4e24\u79cd\u4eba\u6e90\u5316\u7684\u6297OX40\u5355\u514b\u9686\u6297\u4f53\uff0c\u5373MEDI6383\uff08\u7531\u963f\u65af\u5229\u5eb7\u5f00\u53d1\uff0c\u5546\u54c1\u540d\u4e3aAgonOx\uff09\u548cMOXR0916\uff08\u7531Genentech, \u7f57\u6c0f\u96c6\u56e2\u5f00\u53d1\uff09\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u7814\u7a76\u3002\u8fd9\u4e9b\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u8fd9\u4e9b\u5355\u514b\u9686\u6297\u4f53\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u4ee5\u53ca\u4e0ePD-1\u548cPD-L1\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

26.5 GITR<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8bf1\u5bfc\u7684TNFR\u76f8\u5173\u86cb\u767d\uff08GITR\uff0c\u53c8\u540dTNFRSF18\u6216CD357\uff09\u662fTNFR\u5bb6\u65cf\u7684\u4e00\u5458\u3002\u5176\u540d\u79f0\u6e90\u81ea\u4e8e\u6700\u521d\u5728\u7528\u5730\u585e\u7c73\u677e\u6cbb\u7597\u7684\u5c0f\u9f20T\u7ec6\u80de\u6742\u4ea4\u7624\u4e2d\u7684\u53d1\u73b0\u3002\u540e\u7eed\u7814\u7a76\u8868\u660e\uff0c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5bf9\u4eba\u7c7bGITR\u7684\u8868\u8fbe\u5e76\u65e0\u5f71\u54cd\uff0c\u8fd9\u4e00\u70b9\u5728\u5c0f\u9f20\u4e2d\u4e5f\u975e\u5fc5\u9700\u3002\u76f8\u53cd\uff0cGITR\u7684\u8868\u8fbe\u662f\u7531TCR\u6fc0\u6d3b\u540e\u5728CD4+\u548cCD8+ T\u7ec6\u80de\u4e2d\u8bf1\u5bfc\u7684\u3002\u5728\u8fd9\u4e9bT\u7ec6\u80de\u4e2d\uff0cGITR\u5728\u9759\u606f\u72b6\u6001\u4e0b\u4f4e\u6c34\u5e73\u8868\u8fbe\uff0c\u5e76\u5728TCR\u6fc0\u6d3b\u540e\u768424\u81f372\u5c0f\u65f6\u5185\u8868\u8fbe\u4e0a\u8c03\uff0c\u7ee7\u800c\u5728\u7ec6\u80de\u8868\u9762\u6301\u7eed\u5b58\u5728\u6570\u5929\u3002\u4e0d\u540c\u4e8e\u8fd9\u4e9b\u7ec6\u80de\uff0cTreg\u7ec6\u80de\u4e2dGITR\u7684\u8868\u8fbe\u5219\u662f\u56fa\u6709\u4e14\u663e\u8457\u7684\uff0c\u5b83\u5728\u8fd9\u91cc\u53ef\u80fd\u5bf9Treg\u7684\u6291\u5236\u529f\u80fd\u4ea7\u751f\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9664\u6b64\u4e4b\u5916\uff0cGITR\u4e5f\u5728NK\u7ec6\u80de\u3001\u55dc\u9178\u6027\u548c\u55dc\u78b1\u6027\u7c92\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u4ee5\u53caB\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u7279\u522b\u662f\u5728\u8fd9\u4e9b\u7ec6\u80de\u88ab\u6fc0\u6d3b\u65f6\u3002GITR\u7684\u914d\u4f53\uff08GITRL\uff09\u7c7b\u4f3c\u4e8eOX40L\uff0c\u4e3b\u8981\u5728\u6d3b\u5316\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u548c\u5185\u76ae\u7ec6\u80de\u4e0a\u9ad8\u8868\u8fbe\u3002\u5f53GITRL\u4e0eGITR\u7ed3\u5408\u65f6\uff0c\u901a\u8fc7\u4e00\u4e2a\u5305\u542b\u5355\u4e2aTRAF5\u548c\u4e24\u4e2aTRAF2\u7684\u590d\u5408\u4f53\u6765\u4f20\u9012\u4fe1\u53f7\uff0c\u4ece\u800c\u6fc0\u6d3bNF-\u03ba\u03b2\u548cMAPK\u4fe1\u53f7\u901a\u8def\u3002\u8fd9\u79cd\u7531GITR\u4ecb\u5bfc\u7684\u5171\u523a\u6fc0\u4f5c\u7528\u6700\u7ec8\u589e\u5f3a\u4e86T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6548\u5e94\u529f\u80fd\uff0c\u90e8\u5206\u539f\u56e0\u662f\u7531\u4e8e\u4e0a\u8c03\u4e86IL-2R\u03b1\u3001IL-2\u548cIFN\u03b3\u3002\u6b64\u5916\uff0cGITR\u7684\u6fc0\u6d3b\u8fd8\u53ef\u4ee5\u4fdd\u62a4T\u7ec6\u80de\u514d\u53d7\u6d3b\u5316\u8bf1\u5bfc\u7684\u7ec6\u80de\u6b7b\u4ea1\uff08AICD\uff09\uff0c\u5e76\u4fc3\u8fdb\u8bb0\u5fc6\u6027T\u7ec6\u80de\u7684\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u521d\u6b65\u7814\u7a76\u663e\u793a\uff0cGITR\u6fc0\u6d3b\u53ef\u80fd\u6709\u52a9\u4e8e\u514b\u670d\u5bf9\u81ea\u8eab\u548c\u80bf\u7624\u6297\u539f\u7684\u8010\u53d7\u6027\uff0c\u8fd9\u4f7f\u5f97\u5b83\u6210\u4e3a\u5f00\u53d1\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u4e00\u4e2a\u6709\u5438\u5f15\u529b\u7684\u9776\u70b9\u3002\u5728\u591a\u79cd\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u901a\u8fc7\u4f7f\u7528\u6fc0\u52a8\u6027\u6297GITR\u5355\u6297\uff08\u5982\u5927\u9f20\u5355\u514b\u9686\u6297\u4f53DTA-1\uff09\u6216\u64cd\u4f5cGITRL\uff0c\u5df2\u8bc1\u660eGITR\u523a\u6fc0\u5177\u6709\u6297\u80bf\u7624\u6548\u679c\u3002\u7279\u522b\u662f\uff0cDTA-1\u5bf9\u4e8e\u6cbb\u75978\u5929\u7684Meth-A\u8089\u7624\u3001CT26\u7ed3\u80a0\u764c\u548c\u5c0f\u578b\u7684B16\u9ed1\u8272\u7d20\u7624\u663e\u793a\u51fa\u6709\u6548\u6027\u3002\u6b64\u5916\uff0c\u5f53GITR\u6fc0\u52a8\u5242\u4e0e\u75ab\u82d7\u3001TLR\u6fc0\u52a8\u5242\u4ee5\u53ca\u5176\u4ed6\u514d\u75ab\u523a\u6fc0\u6027\u5355\u514b\u9686\u6297\u4f53\uff08\u4f8b\u5982\u6297CTLA-4\u6297\u4f53\uff09\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u8868\u73b0\u51fa\u4e86\u663e\u8457\u7684\u534f\u540c\u6297\u80bf\u7624\u4f5c\u7528\u3002\u91cd\u7ec4GITRL\u4e5f\u5df2\u6210\u529f\u5730\u5e94\u7528\u4e8e\u7ecf\u8fc7\u5de5\u7a0b\u6539\u9020\u7684\u6811\u7a81\u7ec6\u80de\uff08DCs\uff09\uff0c\u4f7f\u5176\u80fd\u591f\u5206\u6ccc\u53ef\u6eb6\u6027\u7684GITRL\u878d\u5408\u86cb\u767d\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3a\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

GITR\u6fc0\u52a8\u5242\u7684\u6297\u80bf\u7624\u4f5c\u7528\u53ef\u80fd\u901a\u8fc7\u591a\u79cd\u673a\u5236\u5b9e\u73b0\uff0c\u5176\u4e2d\u6700\u4e3a\u5173\u952e\u7684\u53ef\u80fd\u662f\u5176\u5728\u524a\u5f31Treg\u7ec6\u80de\u5bf9\u6548\u5e94T\u7ec6\u80de\uff08Teff\u7ec6\u80de\uff09\u6291\u5236\u4f5c\u7528\u4e2d\u7684\u89d2\u8272\u3002\u7814\u7a76\u8868\u660e\uff0cGITR\u6fc0\u52a8\u5242\u53ef\u4ee5\u901a\u8fc7\u76f4\u63a5\u4f5c\u7528\u4e8eTreg\u7ec6\u80de\uff0c\u51cf\u5f31\u5176\u8868\u8fbe\u7684FoxP3\uff0c\u8fd9\u662fTreg\u7684\u5173\u952e\u8c03\u63a7\u56e0\u5b50\uff0c\u4ece\u800c\u6291\u5236Treg\u7684\u529f\u80fd\u3002\u6b64\u5916\uff0cGITR\u6fc0\u52a8\u5242\u8fd8\u53ef\u80fd\u589e\u5f3a\u6297\u539f\u7279\u5f02\u6027CD8+T\u7ec6\u80de\u5bf9Treg\u7684\u6291\u5236\u7684\u62b5\u6297\u80fd\u529b\uff0c\u4ece\u800c\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u524a\u5f31Treg\u7684\u6548\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8fd1\u671f\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u6297GITR\u5355\u514b\u9686\u6297\u4f53\uff08\u5982DTA-1\uff09\u53ef\u80fd\u901a\u8fc7\u6fc0\u6d3bFc\u03b3\u53d7\u4f53\u7684\u65b9\u5f0f\uff0c\u76f4\u63a5\u5728\u80bf\u7624\u5185\u90e8\u6d88\u8017Treg\u7ec6\u80de\uff0c\u8fd9\u662f\u5176\u6f5c\u5728\u7684\u4f5c\u7528\u673a\u5236\u4e4b\u4e00\u3002\u652f\u6301\u8fd9\u4e00\u673a\u5236\u7684\u8bc1\u636e\u5305\u62ec\u5728DTA-1\u6cbb\u7597\u540e\uff0c\u80bf\u7624\u90e8\u4f4d\u7684Teff\/Treg\u6bd4\u4f8b\u589e\u52a0\uff0c\u8fd9\u4e00\u53d8\u5316\u4e0e\u6cbb\u7597\u7684\u6709\u6548\u6027\u7d27\u5bc6\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u76ee\u524d\uff0c\u51e0\u79cd\u4eba\u6e90\u5316GITR\u6fc0\u52a8\u5242\u5355\u514b\u9686\u6297\u4f53\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002TRX518\u662f\u7531Tolx\u516c\u53f8\uff08\u73b0\u66f4\u540d\u4e3aGITR Inc.\uff09\u5f00\u53d1\u7684\uff0c\u76ee\u524d\u5728\u7eaa\u5ff5\u65af\u9686\u00b7\u51ef\u7279\u6797\u764c\u75c7\u4e2d\u5fc3\uff08Memorial Sloan Kettering Cancer Center\uff09\u53ca\u5176\u4ed6\u7814\u7a76\u673a\u6784\u8fdb\u884c\u5242\u91cf\u9012\u589e\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u5177\u6709\u7c7b\u4f3c\u4f5c\u7528\u7684\u5176\u4ed6\u5355\u514b\u9686\u6297\u4f53\uff0c\u5982INCAGN01876\uff08\u7531Incyte\u5f00\u53d1\uff09\u548cMEDI1873\uff08\u7531Medimmune\u5f00\u53d1\uff09\uff0c\u4e5f\u5df2\u5f00\u59cb\u4e34\u5e8a\u6d4b\u8bd5\uff0c\u6211\u4eec\u671f\u5f85\u8fd9\u4e9b\u7814\u7a76\u5e26\u6765\u79ef\u6781\u7684\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

ACT adoptive cell therapy ACT\u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5<\/p>\n

KLH keyhole-limpet hemocyanin  \u8840\u84dd\u86cb\u767d<\/p>\n

RFA radiofrequency ablation \u5c04\u9891\u6d88\u878d\u672f<\/p>\n

ONT-10\u662f\u4e00\u79cd\u7528PET\u8102\u8d28a\u4f50\u5242\u914d\u5236\u7684\u8102\u8d28\u4f53\u5408\u6210\u7cd6\u5171\u80bdMUC1\u9776\u5411\u6297\u539f<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
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<\/p>\n<\/section>\n<\/section>\n

\n
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26.6 CD27<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

CD27\u662fTNFR\u5bb6\u65cf\u7684\u4e00\u4e2a\u6210\u5458\uff0c\u5176\u5728\u5927\u591a\u6570T\u7ec6\u80de\uff08\u4e3b\u8981\u662f\u521d\u7ea7T\u7ec6\u80de\uff09\u4e0a\u5177\u6709\u7ed3\u6784\u6027\u548c\u6301\u7eed\u7684\u8868\u8fbe\uff0c\u8fd9\u662f\u5176\u5728TNFR\u5bb6\u65cf\u4e2d\u7684\u4e00\u4e2a\u72ec\u7279\u7279\u5f81\u3002\u6b64\u5916\uff0cCD27\u4e5f\u4f5c\u4e3a\u4e00\u4e2a\u6807\u5fd7\u7269\u5728\u6d46\u7ec6\u80de\u4e0a\u8868\u8fbe\u3002CD27\u7684\u8fd9\u79cd\u666e\u904d\u8868\u8fbe\u6a21\u5f0f\u610f\u5473\u7740\u5176\u552f\u4e00\u5df2\u77e5\u914d\u4f53CD70\u7684\u8868\u8fbe\u5fc5\u987b\u88ab\u4e25\u683c\u63a7\u5236\u3002\u5b9e\u9645\u4e0a\uff0cCD70\u5728\u6b63\u5e38\u751f\u7406\u6761\u4ef6\u4e0b\u53ea\u5728\u6fc0\u6d3b\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u3001T\u7ec6\u80de\u548cNK\u7ec6\u80de\u4e0a\u77ed\u6682\u8868\u8fbe\u3002\u7136\u800c\uff0c\u5728\u6162\u6027\u708e\u75c7\u6761\u4ef6\u4e0b\uff0cCD70\u7684\u6301\u7eed\u8868\u8fbe\u5df2\u7ecf\u88ab\u8bc1\u5b9e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76f8\u53cd\uff0c\u6301\u7eed\u7684CD70\u8868\u8fbe\u6709\u65f6\u4f1a\u5bfc\u81f4T\u7ec6\u80de\u529f\u80fd\u969c\u788d\uff0c\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u5728\u6162\u6027\u611f\u67d3\u4e2d\u89c2\u5bdf\u5230\uff0c\u5982LCMV\uff08\u6dcb\u5df4\u7ec6\u80de\u6027\u810a\u9ad3\u7070\u8d28\u708e\u75c5\u6bd2\uff09\u6162\u6027\u611f\u67d3\u6a21\u578b\u4e2d\u6240\u793a\u3002\u5728\u6b64\u6a21\u578b\u4e2d\uff0cCD70\u4e0eCD27\u7684\u6301\u7eed\u76f8\u4e92\u4f5c\u7528\u88ab\u53d1\u73b0\u6709\u52a9\u4e8e\u6e05\u9664\u611f\u67d3\uff0c\u663e\u793a\u4e86\u5176\u5728\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u590d\u6742\u6027\u548c\u53cc\u9762\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ed3\u6784\u6027\u7684CD70\u8868\u8fbe\u5df2\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u88ab\u8bc1\u5b9e\u3002\u7279\u522b\u662f\u5728\u80bf\u7624\u7ec6\u80de\u6216\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APCs\uff09\u4e0a\u7684\u6301\u7eedCD70\u8868\u8fbe\uff0c\u5df2\u5728\u5c0f\u9f20\u7684\u6dcb\u5df4\u7624\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\uff0c\u5b83\u80fd\u663e\u8457\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u548cNK\u7ec6\u80de\u4ecb\u5bfc\u7684\u6392\u65a5\u53cd\u5e94\u3002\u8fd9\u4e9b\u53d1\u73b0\u652f\u6301\u4e86\u4f7f\u7528\u6fc0\u52a8\u578b\u6297CD27\u6297\u4f53\u4f5c\u4e3a\u6cbb\u7597\u624b\u6bb5\u7684\u6982\u5ff5\uff0c\u5b9e\u9a8c\u8bc1\u660e\u8fd9\u79cd\u6297\u4f53\u80fd\u963b\u6b62\u4e24\u79cd\u4e0d\u540c\u7684\u6dcb\u5df4\u7624\u7ec6\u80de\u7cfb\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u5f62\u6210\u80bf\u7624\uff0c\u5e76\u80fd\u5ef6\u7f13B16\u9ed1\u8272\u7d20\u7624\u7684\u751f\u957f\u3002<\/p>\n

\u7136\u800c\uff0c\u5b8c\u6574\u7684CD27\/CD70\u4fe1\u53f7\u4f20\u5bfc\u5e38\u4e0e\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u51cf\u5f31\u53ca\u80bf\u7624\u5185\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u589e\u52a0\u76f8\u5173\u8054\u3002\u8fd9\u8868\u660e\uff0cCD27\u7684\u4f5c\u7528\u6781\u5927\u5730\u53d7\u5230CD70\u8868\u8fbe\u7684\u7ec4\u7ec7\u73af\u5883\u4ee5\u53caCD27\u4e0eCD70\u4e4b\u95f4\u8fde\u63a5\u7684\u6301\u7eed\u65f6\u95f4\u7684\u5f71\u54cd\u3002\u56e0\u6b64\uff0cCD27\u76f8\u5173\u836f\u7269\u7684\u4e34\u5e8a\u5f00\u53d1\u9700\u8981\u7cbe\u786e\u5730\u5728\u7279\u5b9a\u73af\u5883\u4e2d\u6fc0\u6d3b\u7279\u5b9a\u7684\u5206\u5b50\uff0c\u4ee5\u907f\u514d\u52a0\u5267\u80bf\u7624\u8bf1\u5bfc\u7684\u514d\u75ab\u6291\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u4e00\u79cd\u5168\u4eba\u6e90\u6027\u7684\u6fc0\u52a8\u578b\u6297CD27\u5355\u514b\u9686\u6297\u4f53\uff0cCDX-1127\uff08\u7531Celldex Therapeutics, Inc.\uff0cNeedham, MA, USA\u5f00\u53d1\uff09\uff0c\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8fd9\u4e9b\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30\u5176\u5bf9\u7279\u5b9a\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u6548\u679c\u3002\u901a\u8fc7\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6211\u4eec\u5e0c\u671b\u80fd\u591f\u66f4\u597d\u5730\u7406\u89e3CD27\/CD70\u8def\u5f84\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\u548c\u6311\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e34\u5e8a\u4e0a\u7684\u6210\u529f\u6848\u4f8b\uff0c\u5982Ipilimumab\uff08\u4e00\u79cd\u6297CTLA-4\u6297\u4f53\uff09\u3001\u6297PD-1\u548c\u6297PD-L1\u5355\u514b\u9686\u6297\u4f53\uff0c\u5df2\u7ecf\u8bc1\u5b9e\u8c03\u8282\u514d\u75ab\u53cd\u5e94\u53ef\u4ee5\u6709\u6548\u514b\u670d\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u673a\u5236\uff0c\u5e76\u53ef\u4ee5\u5f15\u53d1\u5b9e\u8d28\u6027\u7684\u6297\u80bf\u7624\u53cd\u5e94\u3002\u7136\u800c\uff0c\u6bcf\u4e2a\u60a3\u8005\u7684\u80bf\u7624\u53ef\u80fd\u53d1\u5c55\u51fa\u72ec\u7279\u7684\u514d\u75ab\u9003\u907f\u7b56\u7565\uff0c\u5f53\u524d\u7684\u6311\u6218\u5728\u4e8e\u786e\u5b9a\u54ea\u4e00\u79cd\u9003\u907f\u673a\u5236\u662f\u4e3b\u5bfc\u7684\uff0c\u4ee5\u53ca\u5982\u4f55\u9009\u62e9\u6700\u9002\u5408\u7684\u4e2a\u4f53\u5316\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u3002\u4e34\u5e8a\u5b9e\u8df5\u663e\u793a\uff0c\u5e76\u975e\u6240\u6709\u60a3\u8005\u90fd\u5bf9CTLA-4\u6216PD-1\/PD-L1\u963b\u65ad\u5242\u654f\u611f\u3002\u56e0\u6b64\uff0c\u63ed\u793a\u8fd9\u4e9b\u539f\u53d1\u6027\u8010\u836f\u6027\u7684\u673a\u5236\uff0c\u5e76\u6df1\u5165\u7406\u89e3\u80bf\u7624\u514d\u75ab\u6d78\u6da6\u7684\u5f02\u8d28\u6027\uff0c\u662f\u4e2a\u4f53\u5316\u533b\u7597\u5b9e\u65bd\u53ca\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u9886\u57df\u53d1\u5c55\u7ec4\u5408\u7597\u6cd5\u7684\u5173\u952e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u7ed3\u5408\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08\u5373\u963b\u65ad\u5171\u6291\u5236\u5206\u5b50\uff09\u548c\u5171\u523a\u6fc0\u5206\u5b50\u5355\u514b\u9686\u6297\u4f53\u7684\u7b56\u7565\uff0c\u88ab\u8ba4\u4e3a\u662f\u7ee7CTLA-4\u548c\u6297PD-1\u7ec4\u5408\u6cbb\u7597\u540e\u6700\u6709\u6f5c\u529b\u7684\u65b9\u6cd5\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u7ed3\u5408\u6297PD-1\u548c\u6297CD137\uff08\u4e00\u4e2a\u91cd\u8981\u7684\u514d\u75ab\u523a\u6fc0\u5206\u5b50\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u542f\u52a8\uff0c\u76f8\u5173\u7684\u8bd5\u9a8c\u7f16\u53f7\u5305\u62ecNCT02253992\u548cNCT02179918\u3002\u8003\u8651\u5230CD137\u5728\u6fc0\u6d3b\u7684NK\u7ec6\u80de\u4e0a\u901a\u8fc7Fc\u03b3Rs-Fc\u7ed3\u5408\u8868\u8fbe\uff0c\u6297CD137\u5355\u514b\u9686\u6297\u4f53\u5df2\u7ecf\u4e0e\u6297EGFR\u3001\u6297CD20\u6216\u6297HER-2\u5355\u514b\u9686\u6297\u4f53\u5728\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\u8fdb\u884c\u4e86\u6210\u529f\u7684\u8054\u5408\u6d4b\u8bd5\u3002\u8fd9\u4e9b\u7ec4\u5408\u76ee\u524d\u5728\u6dcb\u5df4\u7624\u3001\u5934\u9888\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u4f8b\u5982NCT01307267\u548cNCT01775631\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u867d\u7136\u4e0d\u540cTNFRSF\u6210\u5458\u7684\u6fc0\u52a8\u5242\u7ec4\u5408\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u5df2\u8bc1\u660e\u6709\u6548\uff0c\u4f46\u7531\u4e8e\u6fc0\u52a8\u578b\u514d\u75ab\u523a\u6fc0\u6027\u5355\u514b\u9686\u6297\u4f53\uff08ISMAB\uff09\u53ef\u80fd\u5e26\u6765\u7684\u6bd2\u6027\uff0c\u8fd9\u79cd\u7b56\u7565\u7684\u4e34\u5e8a\u5e94\u7528\u8fd8\u5b58\u5728\u4e00\u5b9a\u7684\u62c5\u5fe7\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u9650\u5236\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u591a\u79cd\u7b56\u7565\uff0c\u8fd9\u4e9b\u7b56\u7565\u4e3b\u8981\u96c6\u4e2d\u5728\u5c06\u6297\u4f53\u66f4\u52a0\u7279\u5f02\u6027\u5730\u9001\u8fbe\u5230\u80bf\u7624\u90e8\u4f4d\uff0c\u6216\u5728\u53ef\u63a7\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u80bf\u7624\u5185\u90e8\u7ed9\u836f\u3002\u76ee\u524d\uff0c\u9488\u5bf9T\u7ec6\u80de\u548cNK\u7ec6\u80de\u7684\u5171\u523a\u6fc0\u53d7\u4f53\u7684\u6fc0\u52a8\u578b\u5355\u514b\u9686\u6297\u4f53\u662f\u65b0\u4e00\u4ee3\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u7684\u4e00\u90e8\u5206\uff0c\u8fd9\u4e9b\u6cbb\u7597\u6b63\u9010\u6e10\u6539\u53d8\u7740\u764c\u75c7\u7684\u6cbb\u7597\u6a21\u5f0f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Ignacio Melero, Elisabeth P\u00e9rez-Ruiz, Alfonso R. Sanchez-Paulete, Alvaro Teijeira, Angela Aznar, and Miguel F. Sanmamed<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u51bc\u91d1\u6b22<\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u675c\u8f7b\u677e<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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