{"id":5635,"date":"2024-04-27T06:47:51","date_gmt":"2024-04-26T22:47:51","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/04\/27\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac27%e7%ab%a0%ef%bc%9a%e8%82%a0%e9%81%93%e8%8f%8c%e7%be%a4%e5%af%b9%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e5%8f%8d%e5%ba%94%e7%9a%84%e5%bd%b1-2\/"},"modified":"2024-04-27T06:47:51","modified_gmt":"2024-04-26T22:47:51","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac27%e7%ab%a0%ef%bc%9a%e8%82%a0%e9%81%93%e8%8f%8c%e7%be%a4%e5%af%b9%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e5%8f%8d%e5%ba%94%e7%9a%84%e5%bd%b1-2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/04\/27\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac27%e7%ab%a0%ef%bc%9a%e8%82%a0%e9%81%93%e8%8f%8c%e7%be%a4%e5%af%b9%e7%99%8c%e7%97%87%e6%b2%bb%e7%96%97%e5%8f%8d%e5%ba%94%e7%9a%84%e5%bd%b1-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c27\u7ae0\uff1a\u80a0\u9053\u83cc\u7fa4\u5bf9\u764c\u75c7\u6cbb\u7597\u53cd\u5e94\u7684\u5f71\u54cd\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c27\u7ae0\uff1a\u80a0\u9053\u83cc\u7fa4\u5bf9\u764c\u75c7\u6cbb\u7597\u53cd\u5e94\u7684\u5f71\u54cd\uff08\u4e0a\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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27.7 \u80a0\u9053\u7ec6\u83cc\u4e0e\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80bf\u7624\u5b66\u5bb6\u73b0\u5728\u8d8a\u6765\u8d8a\u503e\u5411\u4e8e\u4e0d\u4ec5\u4ec5\u901a\u8fc7\u9776\u5411\u80bf\u7624\u7ec6\u80de\u514b\u9686\u8fdb\u884c\u6cbb\u7597\uff0c\u800c\u662f\u901a\u8fc7\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u5e76\u4fc3\u8fdb\u957f\u671f\u8bb0\u5fc6T\u7ec6\u80de\u53cd\u5e94\u6765\u4fdd\u62a4\u60a3\u8005\u514d\u53d7\u5fae\u5c0f\u6b8b\u7559\u75be\u75c5\u7684\u4fb5\u88ad\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\uff08ICB\uff09\u5df2\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u91cd\u8981\u624b\u6bb5\u3002\u7136\u800c\uff0c\u5927\u7ea670%\u7684\u60a3\u8005\u5bf9ICB\u5b58\u5728\u539f\u53d1\u6027\u8010\u836f\uff0c\u8fd9\u8868\u660e\u901a\u8fc7T\u7ec6\u80de\u5728\u80bf\u7624\u90e8\u4f4d\u8fbe\u5230\u6709\u6548\u6d78\u6da6\u548c\u6740\u4f24\u7684\u53cd\u5e94\u662f\u76f8\u5bf9\u7f55\u89c1\u7684\u3002\u4e2a\u4f53\u7684\u514d\u75ab\u54cd\u5e94\u53d7\u5230\u5bbf\u4e3b\u3001\u80bf\u7624\u3001\u73af\u5883\u56e0\u7d20\u53ca\u6cbb\u7597\u5386\u53f2\u7b49\u591a\u79cd\u590d\u6742\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u8fd9\u4e9b\u56e0\u7d20\u5171\u540c\u51b3\u5b9a\u4e86\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684\u9608\u503c\u548c\u6301\u7eed\u6027\u3002\u7814\u7a76\u663e\u793a\uff0c\u5fae\u751f\u7269\u7ec4\u5728\u786e\u5b9a\u4e2a\u4f53\u7684\u201c\u764c\u75c7\u514d\u75ab\u8bbe\u5b9a\u70b9\u201d\u4e2d\u626e\u6f14\u5173\u952e\u89d2\u8272\uff0c\u5f71\u54cd\u514d\u75ab\u53cd\u5e94\u7684\u542f\u52a8\u9608\u503c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8fdb\u884c\u6297\u767d\u7ec6\u80de\u4ecb\u7d20-10\u53d7\u4f53\uff08IL-10R\uff09\u548c\u80de\u5627\u5576\u78f7\u9178\u9e1f\u82f7\u5be1\u8131\u6c27\u6838\u82f7\u9178\uff08CpG-ODN\uff09TLR9\u6fc0\u52a8\u5242\u6cbb\u7597\u540e\uff0c\u7814\u7a76\u53d1\u73b0\u7ed3\u80a0\u764c\u5c0f\u9f20\u7684\u7caa\u4fbf\u4e2d\u6c99\u6c0f\u6cfb\u5b50\u83cc\u6570\u91cf\u8fc7\u591a\u3002\u4e0e\u65e0\u83cc\u5c0f\u9f20\u76f8\u6bd4\uff0c\u7ecf\u8fc7\u706d\u83cc\u5904\u7406\u7684\u5c0f\u9f20\u4e0eA. shahii\u8054\u5408\u540e\uff0c\u76ae\u4e0b\u7ed3\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u5f97\u5230\u663e\u8457\u6539\u5584\u3002\u5728\u6b64\u6a21\u578b\u4e2d\uff0cA. shahii\u80fd\u589e\u52a0\u7624\u5185\u9ad3\u7cfb\u7ec6\u80de\u5206\u6cccTNF-\u03b1\uff0c\u800c\u4e2d\u548cTNF-\u03b1\u540e\u4f1a\u6d88\u9664\u6cbb\u7597\u6548\u679c\uff0c\u8bf4\u660eA. shahii\u901a\u8fc7\u5f71\u54cd\u9ad3\u7cfb\u7ec6\u80de\u7684\u5148\u5929\u514d\u75ab\u6548\u5e94\u56e0\u5b50\uff0c\u91cd\u5851\u80bf\u7624\u5fae\u73af\u5883\u4ee5\u6539\u5584\u514d\u75ab\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5176\u4ed6\u7814\u7a76\u4e5f\u8868\u660e\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICB\uff09\u7684\u529f\u6548\uff0c\u5373\u65e8\u5728\u91cd\u65b0\u6fc0\u6d3b\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\uff0c\u540c\u6837\u4f9d\u8d56\u4e8e\u80a0\u9053\u83cc\u7fa4\u7684\u72b6\u6001\u3002Ipilimumab\uff0c\u4e00\u79cd\u6297CTLA-4\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u663e\u8457\u63d0\u9ad8\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u603b\u751f\u5b58\u7387\uff0c\u957f\u671f\u63a7\u5236\u7387\u9ad8\u8fbe18%\u3002\u7136\u800c\uff0cIpilimumab\u5728\u63a5\u53d7\u6297\u7ed3\u6838\u6cbb\u7597\u7684\u7279\u5b9a\u75c5\u539f\u4f53\u81ea\u7531\uff08SPF\uff09\u5c0f\u9f20\u6216\u65e0\u83cc\u52a8\u7269\u4e2d\u7684\u6297\u80bf\u7624\u6548\u679c\u88ab\u6291\u5236\u3002V\u00e9tizou\u7b49\u4eba\u7684\u7814\u7a76\u8868\u660e\uff0c\u5728CTLA4\u963b\u65ad\u514d\u75ab\u6cbb\u7597\u7684\u80cc\u666f\u4e0b\uff0c\u4e0d\u4ea7\u751f\u80a0\u6bd2\u7d20\u7684\u8106\u5f31\u62df\u6746\u83cc\u83cc\u682a\u8868\u73b0\u51fa\u6297\u764c\u7279\u6027\u3002\u963b\u65ad\u514d\u75ab\u68c0\u67e5\u70b9\u540e\uff0c\u62df\u6746\u83cc\u5728\u56de\u80a0\u548c\u7caa\u4fbf\u4e2d\u7684\u5b58\u5728\u53d7\u5230\u5f71\u54cd\uff0cB. fragilis\u80fd\u591f\u5360\u636e\u4e3b\u5bfc\u5730\u4f4d\uff0c\u4e0e\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u8fc1\u79fb\u548c\u80a0\u7cfb\u819c\u6dcb\u5df4\u7ed3\u7684\u6fc0\u6d3b\u76f8\u5173\uff0c\u4ece\u800c\u5f71\u54cd\u5bf9B. fragilis\u7684\u8bb0\u5fc6T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728CTLA4\u963b\u65ad\u7597\u6cd5\u540e\uff0c\u8106\u5f31\u62df\u6746\u83cc\uff08B. fragilis\uff09\u6240\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u4f9d\u8d56\u4e8e\u767d\u4ecb\u7d2012\uff08IL-12\uff09\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5e26\u6709\u80bf\u7624\u7684\u65e0\u83cc\uff08GF\uff09\u5c0f\u9f20\u5728\u63a5\u53d7\u9488\u5bf9CTLA4\u7684\u6297\u4f53\u6cbb\u7597\u65f6\u8868\u73b0\u51fa\u514d\u75ab\u53cd\u5e94\u4e0d\u8db3\uff0c\u4f46\u8fd9\u4e00\u95ee\u9898\u53ef\u4ee5\u901a\u8fc7\u5355\u72ec\u4e0eB. fragilis\u7ed3\u5408\u53ca\u79fb\u690dCD4+ T\u7ec6\u80de\u6765\u89e3\u51b3\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u6b64\u524d\u5df2\u88abB. fragilis\u6fc0\u6d3b\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u6240\u542f\u52a8\uff0c\u4ece\u800c\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u6709\u8da3\u7684\u662f\uff0c\u4e0e\u5355\u57fa\u56e0\u8106\u5f31\u62df\u6746\u83cc\u76f8\u5173\u7684\u5c0f\u9f20\u5728\u80bf\u7624\u90e8\u4f4d\u663e\u793a\u51fa\u66f4\u6210\u719f\u7684DC\u8868\u578b\uff0c\u8fd9\u4e9bDC\u5177\u6709\u66f4\u9ad8\u7684MHC II\u3001\u5171\u523a\u6fc0\u5206\u5b50CD80\u548cCD86\u7684\u8868\u8fbe\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6587\u732e\u8868\u660e\uff0c\u8106\u5f31\u62df\u6746\u83cc\u7ec6\u80de\u58c1\u542b\u6709\u4e00\u79cd\u514d\u75ab\u523a\u6fc0\u591a\u7cd6A\uff08PSA\uff09\uff0c\u8fd9\u79cd\u7269\u8d28\u80fd\u591f\u6fc0\u6d3b\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5173\u4e8ePSA\u5355\u72ec\u4f7f\u7528\u4e0e\u5b8c\u6574\u6d3b\u83cc\u5728\u6297\u80bf\u7624\u6d3b\u6027\u4e0a\u7684\u6bd4\u8f83\u6548\u679c\uff0c\u76ee\u524d\u5c1a\u65e0\u5b9a\u8bba\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u901a\u8fc7\u5206\u6790\u63a5\u53d7Ipilimumab\u6cbb\u7597\u524d\u540e\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u80a0\u9053\u83cc\u7fa4\u53d8\u5316\uff0c\u7814\u7a76\u8bc1\u5b9e\u4e86\u8fd9\u4e9b\u53d1\u73b0\u7684\u4e34\u5e8a\u76f8\u5173\u6027\u3002\u5bf925\u4f8bIV\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u7caa\u4fbf\u8fdb\u884c16S rRNA\u6d4b\u5e8f\uff0c\u6839\u636e\u62df\u6746\u83cc\u5c5e\u548c\u666e\u96f7\u6c83\u6c0f\u83cc\u5c5e\u7684\u83cc\u79cd\u4e30\u5ea6\u6216\u76f8\u5bf9\u4ee3\u8868\u6027\uff0c\u63ed\u793a\u4e86\u4e09\u79cd\u4e3b\u8981\u7684\u80a0\u9053\u83cc\u578b\u3002\u901a\u8fc7\u5c06\u6bcf\u79cd\u83cc\u578b\u7684\u7caa\u4fbf\u5fae\u751f\u7269\u79fb\u690d\uff08FMT\uff09\u5230\u63a5\u53d7\u6297CTLA4\u6297\u4f53\u6cbb\u7597\u7684\u8377\u7624\u65e0\u83cc\u5c0f\u9f20\u4e2d\uff0c\u8bc1\u5b9e\u4e86\u5bcc\u542b\u514d\u75ab\u539f\u6027\u62df\u6746\u83cc\u7269\u79cd\u7684\u80a0\u578bC\u7684\u5fae\u751f\u7269\u7ec4\u6210\u80fd\u591f\u652f\u6301\u8106\u5f31\u62df\u6746\u83cc\u7684\u5b9a\u690d\u5e76\u6062\u590d\u5bf9CTLA4\u6297\u4f53\u7684\u7597\u6548\uff0c\u800c\u5728\u65e0\u83cc\u5c0f\u9f20\u4e2d\u8be5\u6548\u679c\u4f1a\u4e27\u5931\uff0c\u800c\u80a0\u578bA\u548cB\u672a\u80fd\u8fbe\u5230\u8fd9\u4e00\u6548\u679c\u3002\u5728\u63a5\u53d7Ipilimumab\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u503e\u5411\u4e8e\u8868\u73b0\u51fa\u80a0\u578bC\u7684\u7279\u5f81\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Gajewski\u56e2\u961f\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u53cc\u6b67\u6746\u83cc\u79cd\uff08\u5982Bifidobacterium breve\u548cBifidobacterium longum\uff09\u7684\u80cc\u666f\u4e0b\uff0c\u6297PD-L1\u6297\u4f53\u7684\u6297\u80bf\u7624\u6548\u679c\u53d7\u5230\u7ed3\u80a0\u4e2d\u8fd9\u4e9b\u83cc\u79cd\u542b\u91cf\u7684\u663e\u8457\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cSivan\u53ca\u5176\u540c\u4e8b\u6bd4\u8f83\u4e86\u6765\u81ea\u4e24\u4e2a\u4e0d\u540c\u4f9b\u5e94\u5546\u7684\u57fa\u56e0\u76f8\u4f3c\u7684C57BL\/6\u80bf\u7624\u643a\u5e26\u8005\u5c0f\u9f20\u7684\u6297\u80bf\u7624CTL\u53cd\u5e94\uff0c\u53d1\u73b0\u8fd9\u4e9b\u5c0f\u9f20\u7684\u5fae\u751f\u7269\u7ec4\u6210\u5b58\u5728\u5dee\u5f02\u3002\u901a\u8fc7\u5bf9\u6bd4Jackson\u5b9e\u9a8c\u5ba4\u548cTaconic\u519c\u573a\u7684\u5c0f\u9f20\uff0c\u7814\u7a76\u56e2\u961f\u89c2\u5bdf\u5230\uff0c\u4eceTaconic\u519c\u573a\u7684\u5c0f\u9f20\u4e2d\u76ae\u4e0b\u690d\u5165\u7684\u9ed1\u8272\u7d20\u7624\u5c55\u793a\u4e86\u66f4\u5f3a\u7684\u4fb5\u88ad\u6027\uff0c\u8fd9\u4e0e\u8f83\u4f4e\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u6210\u719f\u5ea6\u548cIFN\u6807\u8bb0\u7684\u8868\u8fbe\u6709\u5173\uff0c\u540c\u65f6\u4e5f\u4e0e\u80bf\u7624\u5185\u7279\u5f02\u6027\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u7684\u8f83\u5dee\u79ef\u7d2f\u76f8\u5173\u3002\u6709\u8da3\u7684\u662f\uff0c\u5c06Taconic\u519c\u573a\u7684\u5c0f\u9f20\u4e0e\u6765\u81eaJackson\u5b9e\u9a8c\u5ba4\u7684\u5c0f\u9f20\u5171\u540c\u9972\u517b\u6216\u8fdb\u884c\u7caa\u4fbf\u5fae\u751f\u7269\u79fb\u690d\uff08FMT\uff09\u540e\uff0c\u80bf\u7624\u751f\u957f\u6709\u6240\u51cf\u7f13\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7caa\u4fbf\u57fa\u56e0\u6269\u589e\u5b50\u7684\u6d4b\u5e8f\u5206\u6790\u663e\u793a\uff0c\u53cc\u6b67\u6746\u83cc\u5728\u8fd9\u4e9b\u5c0f\u9f20\u7684\u80a0\u9053\u4e2d\u542b\u91cf\u8f83\u9ad8\uff0c\u4e0e\u79fb\u690d\u6027\u9ed1\u8272\u7d20\u7624\u7684\u751f\u957f\u51cf\u7f13\u548cCTL\u4ecb\u5bfc\u7684\u514d\u75ab\u76d1\u89c6\u7684\u6539\u5584\u76f8\u5173\u3002\u5c06B. breve\u6216B. longum\u9009\u62e9\u6027\u5730\u8f6c\u79fb\u5230\u901a\u5e38\u7f3a\u4e4f\u8fd9\u4e9b\u83cc\u682a\u7684\u5c0f\u9f20\u4f53\u5185\uff0c\u8db3\u4ee5\u51cf\u5c11\u9ed1\u8272\u7d20\u7624\u7684\u751f\u957f\u5e76\u6062\u590d\u5bf9\u9ed1\u8272\u7d20\u7624\u7684CTL\u53cd\u5e94\u3002B. longum\u5728\u4f53\u5916\u548c\u4f53\u5185\u90fd\u80fd\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6210\u719f\u3002\u56e0\u6b64\uff0c\u5728\u643a\u5e26B. breve\u6216B. longum\u7684\u5c0f\u9f20\u4e2d\uff0c\u80bf\u7624\u7279\u5f02\u6027CTL\u5728\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u79ef\u7d2f\u9891\u7387\u589e\u52a0\uff0c\u8fd9\u79cdCTL\u6d78\u6da6\u7684\u80bf\u7624\u5bf9\u9776\u5411PD-L1\u6297\u4f53\u7684\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u66f4\u52a0\u5f3a\u70c8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8fd9\u4e9b\u53d1\u73b0\u7a81\u51fa\u4e86\u4e0d\u540c\u5171\u751f\u83cc\u682a\u4e0e\u514d\u75ab\u80bf\u7624\u6cbb\u7597\u7b56\u7565\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u672a\u6765\u7684\u7814\u7a76\u5c06\u63ed\u793a\u8fd9\u4e9b\u5171\u751f\u83cc\u662f\u5426\u80fd\u591f\u4ecb\u5bfc\u6cbb\u7597\u5316\u5408\u7269\u5bf9\u5148\u5929\u6216\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u751f\u7269\u6d3b\u6027\uff0c\u4ee5\u53ca\u5b83\u4eec\u5728\u786e\u5b9a\u7684\u5316\u5408\u7269\u7684\u4f5c\u7528\u6a21\u5f0f\u548c\u8303\u56f4\u5185\u5982\u4f55\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

27.8 \u80a0\u9053\u5fae\u751f\u7269\u5728\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5(GVHD)\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d(allo- HSCT)\u540e\u53d1\u751f\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff0c\u5e38\u5e38\u9650\u5236\u6cbb\u7597\u7684\u6210\u529f\u3002\u79fb\u690d\u7269\u4f9b\u4f53\u514d\u75ab\u7ec6\u80de\u5bf9\u5bbf\u4e3b\u7ec6\u80de\u7684\u653b\u51fb\u662fGVHD\u7684\u7ed3\u679c\u3002\u5927\u91cf\u7814\u7a76\u8868\u660e\uff0c\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u7684\u53d1\u751f\u53d6\u51b3\u4e8e\u591a\u79cd\u56e0\u7d20\uff0c\u5982\u5e74\u9f84\u3001\u8c03\u7406\u65b9\u6848\u3001\u79fb\u690d\u7269\u6765\u6e90\u7b49\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6b64\u5916\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u80a0\u9053\u83cc\u7fa4\u5728GVHD\u7684\u53d1\u75c5\u673a\u5236\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u53ef\u80fd\u4e0e\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u8840\u6db2\u6076\u6027\u80bf\u7624\u590d\u53d1\u6709\u5173\u3002\u5148\u524d\u5728\u5c0f\u9f20\u4e2d\u8fdb\u884c\u7684\u7814\u7a76\u8868\u660e\uff0c\u5728GF\u5c0f\u9f20\u6216\u63a5\u53d7\u6297\u751f\u7d20\u6cbb\u7597\u7684\u5c0f\u9f20\u6216\u5728\u4eba\u7c7b\u4e2d\uff0cGVHD\u7684\u4e25\u91cd\u7a0b\u5ea6\u51cf\u5f31\u3002GVHD\u60a3\u8005\u7684\u80a0\u9053\u83cc\u7fa4\u7279\u5f81\u663e\u793a\uff0c\u591a\u6837\u6027\u663e\u8457\u4e0b\u964d\uff0c\u8fd9\u4e0e\u4e73\u9178\u6746\u83cc\u7684\u589e\u52a0\u548c\u68ad\u72b6\u82bd\u80de\u6746\u83cc\u7684\u51cf\u5c11\u6709\u5173\uff0c\u800c\u68ad\u72b6\u82bd\u80de\u6746\u83cc\u53ef\u8c03\u8282\u80a0\u9053\u708e\u75c7\u3002\u5728\u540e\u6765\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0cJenq\u7b49\u4eba\u5c06\u5c5e\u4e8e\u68ad\u72b6\u82bd\u80de\u6746\u83cc\u7c7b\u7684Blautia\u7684\u4e30\u5ea6\u4e0eGVDH\u76f8\u5173\u7684\u6b7b\u4ea1\u7387\u8fdb\u884c\u4e86\u53cd\u76f8\u5173\u7814\u7a76\u3002\u867d\u7136\u7caa\u4fbf\u6746\u83cc\u6216\u7624\u80c3\u7403\u83cc\u7b49\u5177\u6709\u4fc3\u8fdb\u5065\u5eb7\u7279\u6027\u7684\u7ec6\u83cc\u79cd\u7c7b\u5927\u5e45\u51cf\u5c11\uff0c\u4f46\u4e0e\u6ca1\u6709GVHD\u7684\u60a3\u8005\u76f8\u6bd4\uff0cGVHD\u60a3\u8005\u80a0\u7403\u83cc\u7684\u4e30\u5ea6\u663e\u8457\u589e\u5f3a\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728\u60a3\u6709\u4e25\u91cd\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u7684\u6210\u4eba\u60a3\u8005\u4e2d\uff0c\u79fb\u690d\u540e\u80a0\u7403\u83cc\u7684\u6570\u91cf\u6709\u6240\u589e\u52a0\u3002\u572810\u4f8b\u63a5\u53d7\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u513f\u7ae5\u60a3\u8005\u4e2d\u4e5f\u89c2\u5bdf\u5230\u8fd9\u79cd\u60c5\u51b5\u3002\u6709\u8da3\u7684\u662f\uff0c\u63a5\u53d7GVHD\u7684\u60a3\u8005\u663e\u793a\u8f83\u4f4e\u7684\u62df\u6746\u83cc\u548c\u526f\u6746\u83cc\uff0c\u5b83\u4eec\u7684\u4e30\u5ea6\u4e0eSCFAs\u6c34\u5e73\u5448\u6b63\u76f8\u5173\uff0c\u5c24\u5176\u662f\u4e19\u9178\uff0c\u5728\u5f02\u57fa\u56e0hsct\u4e4b\u524d\u3002\u6700\u8fd1\uff0cSimms-Waldrip\u7b49\u4eba\u8bc1\u5b9e\uff0c\u5728\u5f02\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u9488\u5bf9\u538c\u6c27\u83cc\u7684\u6297\u751f\u7d20\u4e0e\u6297\u708e\u68ad\u72b6\u82bd\u80de\u6746\u83cc\u7684\u663e\u8457\u4e0b\u964d\u548cGVHD\u7684\u53d1\u5c55\u76f8\u5173\u3002<\/p>\n<\/section>\n

\n
\n
\n

\u56e0\u6b64\uff0c\u901a\u8fc7\u4f7f\u7528\u76ca\u751f\u83cc\u6216\u76ca\u751f\u5143\u6765\u63a7\u5236\u80a0\u9053\u83cc\u7fa4\u53ef\u4ee5\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u65e8\u5728\u964d\u4f4e\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u98ce\u9669\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u521d\u6b65\u6570\u636e\u663e\u793a\uff0c\u5728\u5f02\u57fa\u56e0hsct\u524d\u540e\u7ed9\u836f\u9f20\u674e\u7cd6\u4e73\u6746\u83cc\u53ef\u964d\u4f4e\u4e25\u91cd\u7684\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff0c\u63d0\u9ad8\u5c0f\u9f20\u5b58\u6d3b\u7387\u3002\u5176\u4ed6\u7814\u7a76\u89c2\u5bdf\u5230\uff0c\u4f7f\u7528\u7ea6\u6c0f\u4e73\u6746\u83cc\u53ef\u901a\u8fc7\u9884\u9632\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u80a0\u7403\u83cc\u79ef\u7d2f\u6765\u964d\u4f4e\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6\u3002\u6b64\u5916\uff0cFMT\u5728\u4e00\u9879\u4e34\u5e8a\u4e2d\u8bd5\u7814\u7a76\u4e2d\u88ab\u7528\u4e8e\u6cbb\u7597\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u53d1\u751f\u7684\u80a0\u9053\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\u3002\u5927\u591a\u6570\u60a3\u8005fmt\u540e\u4e73\u9178\u83cc\u7684\u4e30\u5ea6\u589e\u52a0\uff0c\u80a0\u9053\u83cc\u7fa4\u8f6c\u5411\u6297\u708e\u72b6\u6001\u3002\u5176\u4ed6\u7814\u7a76\u8868\u660e\uff0cFMT\u53ef\u6709\u6548\u6cbb\u7597\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u7684\u8270\u96be\u68ad\u83cc\u611f\u67d3\u3002\u4ea7\u4e01\u9178\u7684\u68ad\u72b6\u82bd\u80de\u6746\u83cc\u83cc\u682a\u964d\u4f4e\u4e86\u5f02\u57fa\u56e0BMT\u8bf1\u5bfc\u7684\u80a0\u9053GVHD\u3002\u8fd9\u79cd\u4f5c\u7528\u4e0e\u6539\u5584\u8fde\u63a5\u5b8c\u6574\u6027\u548c\u51cf\u5c11\u80a0\u4e0a\u76ae\u7ec6\u80de\u51cb\u4ea1\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0cPeled\u7b49\u4eba\u62a5\u9053\u4e86\u80a0\u5185\u8102\u80aa\u771f\u6746\u83cc\u7684\u4e30\u5bcc\u7a0b\u5ea6\u4e0eallo- HSCT\u540e\u8840\u6db2\u6076\u6027\u80bf\u7624\u590d\u53d1\/\u8fdb\u5c55\u7684\u98ce\u9669\u964d\u4f4e\u6709\u5173\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u63a5\u53d7\u5168T\u7ec6\u80de\u79fb\u690d\u7684\u60a3\u8005\u4e2d\uff0c\u4e73\u6746\u83cc\u4e0e\u75be\u75c5\u590d\u53d1\u98ce\u9669\u8f83\u4f4e\u7684\u76f8\u5173\u6027\u6700\u5f3a\u3002\u4e0eT\u7ec6\u80de\u7f3a\u5931\u7684\u79fb\u690d\u7269\u53d7\u4f53\u76f8\u6bd4\uff0c\u4f9b\u4f53\u7ec6\u80de\u4ecb\u5bfc\u7684\u79fb\u690d\u7269\u6297\u80bf\u7624(GVT)\u6548\u5e94\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u5b9e\u9645\u4e0a\u66f4\u9ad8\uff0c\u8fd9\u8868\u660e\u80a0\u9053\u83cc\u7fa4\u53ef\u80fd\u5728GVT\u6d3b\u6027\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7814\u7a76\u5f3a\u8c03\u4e86\u80a0\u9053\u83cc\u7fa4\u5728\u6307\u793a\u5f02\u57fa\u56e0\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u7597\u6548\u548c\u6bd2\u6027\u65b9\u9762\u7684\u4e3b\u5bfc\u4f5c\u7528\uff0c\u5e76\u901a\u8fc7\u5229\u7528\u80a0\u9053\u83cc\u7fa4\u5f00\u8f9f\u4e86\u5e72\u9884GVHD\/GVT\u7684\u65b0\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

27.9 \u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u7ec6\u83cc:\u76ca\u751f\u83cc\u548c\u5176\u4ed6<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\uff0c\u5f00\u53d1\u57fa\u4e8e\u6d3b\u5fae\u751f\u7269\u5236\u5242\u7684\u836f\u7269\u4e3b\u8981\u96c6\u4e2d\u5728\u5c40\u90e8\u6216\u5168\u8eab\u7684\u80a0\u5916\u9014\u5f84\u3002William Coley\u662f\u6700\u65e9\u901a\u8fc7\u5411\u80bf\u7624\u5185\u6ce8\u5c04\u5316\u8113\u6027\u94fe\u7403\u83cc\u548c\u9ecf\u8d28\u6c99\u96f7\u6c0f\u83cc\u7684\u6df7\u5408\u7269\uff0c\u90e8\u5206\u6210\u529f\u5730\u5229\u7528\u5fae\u751f\u7269\u5b9e\u73b0\u6297\u764c\u6548\u679c\u7684\u5148\u9a71\u3002\u81ea\u90a3\u4ee5\u540e\uff0c\u8bb8\u591a\u7814\u7a76\u8005\u81f4\u529b\u4e8e\u5f00\u53d1\u57fa\u4e8e\u5fae\u751f\u7269\u7684\u6297\u764c\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5361\u4ecb\u82d7\uff08BCG\uff09\u57281990\u5e74\u88abFDA\u548cEMA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6d45\u8868\u8180\u80f1\u764c\u3002\u5361\u4ecb\u82d7\u7684\u7597\u6548\u4e3b\u8981\u4f9d\u8d56\u4e8e\u8bf1\u5bfc\u5c40\u90e8\u514d\u75ab\u53cd\u5e94\u5bf9\u6297\u6b8b\u7559\u764c\u7ec6\u80de\uff0c\u4ee5\u964d\u4f4e\u590d\u53d1\u7387\u3002\u81ea\u90a3\u65f6\u8d77\uff0c\u5c3d\u7ba1\u8fdb\u884c\u4e86\u591a\u79cd\u7b56\u7565\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u5982Table 27.1\u6240\u5217\uff09\uff0c\u4f46\u672a\u6709\u5176\u4ed6\u7ec6\u83cc\u5236\u5242\u83b7\u5f97\u4e0a\u5e02\u8bb8\u53ef\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 27.1 <\/span>\u5361\u4ecb\u82d7, NK\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff0cMRI\u78c1\u5171\u632f\u6210\u50cf<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8fd1\u5e74\u6765\uff0c\u7814\u7a76\u4eba\u5458\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u65b9\u6cd5\uff1a\u901a\u8fc7\u6ce8\u5c04\u6d3b\u83cc\uff08\u76ca\u751f\u83cc\uff09\u4f7f\u5176\u5728\u80a0\u9053\u5185\u5b9a\u690d\uff0c\u4ece\u800c\u5b9e\u73b0\u6297\u764c\u6d3b\u6027\u3002\u76ca\u751f\u83cc\u88ab\u5b9a\u4e49\u4e3a\u201c\u5f53\u4ee5\u8db3\u591f\u5242\u91cf\u6444\u5165\u65f6\uff0c\u80fd\u4e3a\u5bbf\u4e3b\u5e26\u6765\u5065\u5eb7\u76ca\u5904\u7684\u6d3b\u5fae\u751f\u7269\u201d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4f17\u6240\u5468\u77e5\uff0c\u76ca\u751f\u83cc\u80fd\u589e\u5f3a\u81ea\u7136\u9632\u5fa1\u529b\uff0c\u9884\u9632\u80c3\u80a0\u9053\u75be\u75c5\u548c\u75c5\u539f\u4f53\u611f\u67d3\uff0c\u5e76\u8c03\u8282\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u3002\u4e73\u9178\u83cc\u662f\u76ca\u751f\u83cc\u4e2d\u7684\u91cd\u8981\u4e00\u5458\uff0c\u7814\u7a76\u663e\u793a\uff0c\u4e0d\u540c\u79cd\u7c7b\u7684\u4e73\u9178\u83cc\u5982\u5e72\u916a\u4e73\u6746\u83cc\u3001\u690d\u7269\u4e73\u6746\u83cc\u548c\u9f20\u674e\u7cd6\u4e73\u6746\u83ccGG\u7b49\u901a\u8fc7\u4e0d\u540c\u673a\u5236\u4ecb\u5bfc\u6297\u764c\u4f5c\u7528\uff0c\u5305\u62ec\u6fc0\u6d3bNK\u7ec6\u80de\u3001\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de\u6210\u719f\u6216\u91ca\u653e\u76ca\u751f\u83cc\u884d\u751f\u7684\u751f\u7269\u6d3b\u6027\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

Prohep\u662f\u4e00\u79cd\u7531\u9f20\u674e\u7cd6\u4e73\u6746\u83ccGG\u3001\u5927\u80a0\u57c3\u5e0c\u83ccNissle 1917\u548c\u70ed\u706d\u6d3bVSL#3\u6df7\u5408\u800c\u6210\u7684\u76ca\u751f\u83cc\u4ea7\u54c1\u3002\u5728\u60a3\u6709\u76ae\u4e0b\u809d\u7ec6\u80de\u764c\u7684\u5c0f\u9f20\u4e2d\u53e3\u670dProhep\uff0c\u53ef\u4ee5\u963b\u6b62\u80bf\u7624\u8fdb\u5c55\uff0c\u5e76\u6539\u53d8\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u843d\u7ed3\u6784\uff0c\u4f7f\u4e4b\u503e\u5411\u4e8e\u666e\u96f7\u6c83\u6c0f\u83cc\u548cOscillibacter\u3002\u8fd9\u4e9b\u83cc\u7fa4\u7684\u53d8\u5316\u5bfc\u81f4\u6297\u708e\u4ee3\u8c22\u4ea7\u7269\u7684\u589e\u52a0\uff0c\u4ece\u800c\u964d\u4f4eTh17\u7684\u6781\u5316\u5e76\u589e\u5f3a\u80a0\u9053\u4e2d\u6297\u708eTreg\/Tr1\u7ec6\u80de\u7684\u5206\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u867d\u7136\u8fd9\u4e9b\u76ca\u751f\u83cc\u5355\u72ec\u4f7f\u7528\u53ef\u80fd\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4f46\u5176\u5728\u590d\u5408\u4f7f\u7528\u65f6\u662f\u5426\u80fd\u5f62\u6210\u5177\u6709\u5e7f\u6cdb\u6297\u80bf\u7624\u7279\u6027\u7684\u751f\u6001\u7cfb\u7edf\u4ecd\u6709\u5f85\u786e\u5b9a\u3002
\u6b63\u5982\u4e4b\u524d\u6240\u8ff0\uff0c\u67d0\u4e9b\u80a0\u9053\u5171\u751f\u83cc\u80fd\u8c03\u8282\u6297\u764c\u5316\u5408\u7269\u4ea7\u751f\u7684\u514d\u75ab\u53cd\u5e94\u53ca\u5176\u6cbb\u7597\u6548\u679c\uff0c\u8fd9\u4e9b\u5305\u62ec\u7ed3\u5408CTLA4\u6291\u5236\u5242\u7684\u8106\u5f31\u62df\u6746\u83cc\u3001\u7ed3\u5408\u6297PD-L1\u6297\u4f53\u7684\u957f\u77ed\u53cc\u6b67\u6746\u83cc\u7b49\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8fd9\u4e9b\u5fae\u751f\u7269\u7684\u4f5c\u7528\u673a\u5236\u5c1a\u672a\u5728\u5206\u5b50\u6c34\u5e73\u4e0a\u5b8c\u5168\u9610\u660e\u3002\u8bc6\u522b\u76f4\u63a5\u53c2\u4e0e\u6297\u764c\u6d3b\u6027\u6216\u4fc3\u8fdb\u514d\u75ab\u76d1\u89c6\u7684\u7ec6\u83cc\u7ed3\u6784\u5c06\u6709\u52a9\u4e8e\u901a\u8fc7\u76ca\u751f\u83cc\u5de5\u7a0b\u4f18\u5316\u6297\u80bf\u7624\u6548\u679c\u6216\u5f00\u53d1\u6a21\u62df\u5176\u836f\u7406\u6d3b\u6027\u7684\u5316\u5408\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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27.10 \u8f6c\u57fa\u56e0\u7ec6\u83cc<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

Din\u7b49\u4eba\u5728\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u793a\u4e86\u5229\u7528\u7ec6\u83cc\u5408\u6210\u5de5\u7a0b\u6280\u672f\u6765\u589e\u5f3a\u6297\u4ee3\u8c22\u836f\u72695-\u6c1f\u5c3f\u5627\u5576\uff085-FU\uff09\u7684\u6297\u80bf\u7624\u6548\u679c\u3002\u901a\u8fc7\u57fa\u4e8e\u7fa4\u4f53\u611f\u5e94\u7684\u53cd\u9988\u73af\u8def\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5141\u8bb8\u7ec6\u83cc\u540c\u6b65\u91ca\u653e5-FU\uff0c\u5b9e\u73b0\u8109\u51b2\u5f0f\u7684\u836f\u7269\u4f20\u9012\u3002\u5728\u7279\u5f81\u4e3a\u4f4e\u8840\u7ba1\u5316\u7684\u574f\u6b7b\u6027\u80bf\u7624\u4e2d\uff0c\u7531\u4e8e\u836f\u7269\u53ef\u53ca\u6027\u53d7\u9650\uff0c\u5316\u7597\u7684\u7597\u6548\u5f80\u5f80\u53d7\u5230\u9650\u5236\u3002\u4f7f\u7528\u538c\u6c27\u7ec6\u83cc\u4f5c\u4e3a\u80bf\u7624\u9776\u5411\u8f7d\u4f53\uff0c\u53ef\u4ee5\u90e8\u5206\u5730\u6062\u590d\u8fd9\u79cd\u9650\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u901a\u8fc7\u7ec6\u83cc\u5de5\u7a0b\u589e\u5f3a\u76845-FU\u6cbb\u7597\u5728\u6cbb\u7597\u809d\u8f6c\u79fb\u65f6\u663e\u793a\u51fa\u589e\u5f3a\u7684\u7597\u6548\uff0c\u5c24\u5176\u662f\u5f53\u4e0e\u514d\u75ab\u6cbb\u7597\uff08I-O\uff09\u6216\u5176\u4ed6\u6297\u764c\u836f\u7269\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u8fd9\u79cd\u7b56\u7565\u663e\u5f97\u5c24\u4e3a\u6709\u6548\u3002\u8fd9\u79cd\u72ec\u7279\u7684\u5728\u65e0\u8840\u7ba1\u80bf\u7624\u4e2d\u8f93\u9001\u5316\u5408\u7269\u7684\u65b9\u6cd5\uff0c\u5bf9\u4e8e\u90a3\u4e9b\u5bf9\u4f20\u7edf\u7597\u6cd5\u4ea7\u751f\u8010\u836f\u6027\u7684\u60a3\u8005\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u8bc4\u4f30\u548c\u9a8c\u8bc1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/p>\n<\/section>\n<\/section>\n

\n
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27.11 \u5177\u6709\u764c\u75c7\u8c03\u8282\u7279\u6027\u7684\u5fae\u751f\u7269\u4ea7\u54c1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5fae\u751f\u7269\u5236\u5242\u80fd\u5408\u6210\u4e00\u7cfb\u5217\u5f71\u54cd\u6297\u80bf\u7624\u514d\u75ab\u76d1\u63a7\u548c\u764c\u7ec6\u80de\u751f\u957f\u6216\u5b58\u6d3b\u7684\u5206\u5b50\u3002\u8fd9\u4e9b\u5206\u5b50\u4e3b\u8981\u5305\u62ec\uff1a(a) \u6bd2\u7d20\uff0c(b) \u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRR\uff09\u914d\u4f53\uff0c\u4ee5\u53ca (c) \u4ee3\u8c22\u4ea7\u7269\uff08\u5982\u77ed\u94fe\u8102\u80aa\u9178\u3001\u591a\u80fa\u3001\u7ef4\u751f\u7d20\u3001\u6b21\u751f\u80c6\u6c41\u4ea7\u7269\u3001\u82b3\u9999\u70c3\u53d7\u4f53\uff08AhR\uff09\u914d\u4f53\uff09\u3002\u6bd2\u7d20\u5177\u6709\u76f4\u63a5\u7684\u7ec6\u80de\u6bd2\u6027\u7279\u6027\uff0c\u800c\u6fc0\u6d3bPRR\u7684\u914d\u4f53\u5219\u80fd\u523a\u6fc0\u514d\u75ab\u53cd\u5e94\uff1b\u4ee3\u8c22\u7269\u5219\u76f4\u63a5\u5f71\u54cd\u5bbf\u4e3b\u7684\u4ee3\u8c22\u8fc7\u7a0b\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u67d0\u4e9b\u4ee3\u8c22\u7269\u540c\u65f6\u4e5f\u80fd\u4f5c\u4e3aPRR\u914d\u4f53\uff0c\u4f8b\u5982\uff0cN-\u4e59\u9170\u8461\u8404\u7cd6\u80fa\uff08\u4e00\u79cd\u7ec6\u83cc\u80bd\u805a\u7cd6\u7684\u7cd6\u57fa\u6210\u5206\uff09\u53ef\u4ee5\u6fc0\u6d3bNLRP3\u708e\u75c7\u4f53\u6216\u4f5c\u7528\u4e8eAhR\u7684\u8272\u6c28\u9178\u884d\u751f\u7269\u3002\u8fd9\u4e9b\u673a\u5236\u5df2\u5728\u5148\u524d\u7684\u62a5\u544a\u4e2d\u8be6\u7ec6\u8ba8\u8bba\uff0c\u672c\u6587\u4ec5\u6982\u8ff0\u53ef\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u76ee\u7684\u7684\u6700\u91cd\u8981\u7684\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7ec6\u83cc\u6bd2\u7d20\u901a\u5e38\u662f\u542b\u6709\u4e24\u4eb2\u6027\u03b1-\u87ba\u65cb\u7ed3\u6784\u7684\u591a\u80bd\uff0c\u5e26\u6709\u9633\u79bb\u5b50\u7535\u8377\uff0c\u8fd9\u4f7f\u5176\u80fd\u591f\u5bfc\u81f4\u65e0\u4fdd\u62a4\u7684\u7ec6\u83cc\u819c\u88c2\u89e3\u3002\u4e3a\u4e86\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u5df2\u5f00\u53d1\u51fa\u591a\u79cd\u6bd2\u7d20\u7ed3\u6784\u7c7b\u4f3c\u7269\u3002
LTX-315\u662f\u4e00\u79cd\u7528\u4e8e\u80bf\u7624\u5185\u6cbb\u7597\u7684\u5408\u6210\u80bd\uff0c\u4e13\u95e8\u9776\u5411\u7ebf\u7c92\u4f53\uff0c\u5b83\u8fd8\u80fd\u5f15\u53d1\u5177\u6709\u514d\u75ab\u539f\u6027\u7684\u574f\u6b7b\u6027\u7ec6\u80de\u6b7b\u4ea1\u3002\u8fd9\u610f\u5473\u7740\u5176\u76f4\u63a5\u7684\u80bf\u7624\u6740\u4f24\u4f5c\u7528\u4f1a\u56e0\u5371\u9669\u4fe1\u53f7\u7684\u91ca\u653e\u800c\u88ab\u653e\u5927\uff0c\u4ece\u800c\u6fc0\u6d3b\u9488\u5bf9\u80bf\u7624\u7684\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u79cd\u7b56\u7565\u4e0d\u4ec5\u76f4\u63a5\u653b\u51fb\u80bf\u7624\u7ec6\u80de\uff0c\u8fd8\u901a\u8fc7\u6fc0\u6d3b\u5bbf\u4e3b\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u589e\u5f3a\u6297\u80bf\u7624\u6548\u679c\uff0c\u5c55\u73b0\u4e86\u5fae\u751f\u7269\u5236\u5242\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6570\u79cd\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRR\uff09\u914d\u4f53\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u548c\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u7684\u6279\u51c6\u3002\u5355\u78f7\u9170\u8102A\uff08MPL\uff09\uff0c\u4e00\u79cd\u6765\u6e90\u4e8e\u660e\u5c3c\u82cf\u8fbe\u6c99\u95e8\u6c0f\u83cc\u8102\u591a\u7cd6\uff08LPS\uff09\u7684\u884d\u751f\u7269\uff0c\u5df2\u88ab\u5e7f\u6cdb\u7528\u4f5c\u80bd\u57fa\u75ab\u82d7\u7684\u4f50\u5242\uff0c\u7279\u522b\u662f\u7528\u4e8e\u9884\u9632\u4e0e\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\uff08HPV\uff09\u76f8\u5173\u7684\u5bab\u9888\u764c\u3002\u54aa\u55b9\u83ab\u7279\u662f\u4e00\u79cd\u5408\u6210\u7684TLR7\u6fc0\u52a8\u5242\uff0c\u4e3b\u8981\u7528\u4e8e\u5916\u7528\u6cbb\u7597\u5149\u5316\u6027\u89d2\u5316\u75c5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u77ed\u94fe\u8102\u80aa\u9178\uff08SCFAs\uff09\uff0c\u5982\u4e59\u9178\u3001\u4e01\u9178\u548c\u4e19\u9178\uff0c\u4e3b\u8981\u7531\u81b3\u98df\u7ea4\u7ef4\u548c\u591a\u7cd6\u901a\u8fc7\u539a\u58c1\u83cc\u95e8\u5185\u7684\u68ad\u72b6\u82bd\u80de\u83cc\u7fa4IV\u548cXIVa\u4ea7\u751f\u3002\u5c3d\u7ba1\u4e59\u9178\u53ef\u80fd\u652f\u6301\u591a\u79cd\u4eba\u7c7b\u764c\u75c7\u7c7b\u578b\u7684\u589e\u957f\uff0c\u4e19\u9178\u548c\u4e01\u9178\u5374\u5c55\u73b0\u51fa\u6f5c\u5728\u7684\u6297\u764c\u6d3b\u6027\u3002\u4e19\u9178\u548c\u4e01\u9178\u53ef\u80fd\u901a\u8fc7\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u5206\u5316\u548c\/\u6216\u589e\u52a0\u5176\u6570\u91cf\uff0c\u4ecb\u5bfc\u6297\u708e\u6d3b\u6027\uff0c\u6216\u901a\u8fc7\u6291\u5236\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDACs\uff09\uff0c\u4ece\u800c\u8868\u73b0\u51fa\u6297\u764c\u7279\u6027\uff0c\u5e76\u6709\u52a9\u4e8e\u4fee\u590d\u80a0\u9053\u529f\u80fd\u969c\u788d\u3002\u4e01\u9178\u8fd8\u80fd\u8bf1\u5bfc\u7ed3\u76f4\u80a0\u764c\u548c\u6dcb\u5df4\u7624\u7ec6\u80de\u7684\u51cb\u4ea1\uff0c\u663e\u793a\u51fa\u5176\u76f4\u63a5\u7684\u80bf\u7624\u6740\u4f24\u6d3b\u6027\u3002\u56e0\u6b64\uff0c\u5f00\u53d1\u4e00\u79cd\u996e\u98df\u65b9\u6848\uff0c\u4ee5\u589e\u52a0\u80a0\u9053\u4e2d\u4e01\u9178\u7684\u4ea7\u91cf\u8d85\u8fc7\u4e59\u9178\uff0c\u53ef\u80fd\u6210\u4e3a\u9884\u9632\u6216\u6cbb\u7597\u67d0\u4e9b\u7c7b\u578b\u764c\u75c7\u7684\u6709\u6548\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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27.12 \u672a\u6765\u5c55\u671b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u7f57\u8377<\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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