{"id":5697,"date":"2024-08-14T06:02:27","date_gmt":"2024-08-13T22:02:27","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/08\/14\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac35%e7%ab%a0-%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e7%9a%84%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%ef%bc%9a%e4%b8%80%e4%b8%aa%e4%b8%8d%e6%96%ad-2\/"},"modified":"2024-08-14T06:02:27","modified_gmt":"2024-08-13T22:02:27","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac35%e7%ab%a0-%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e7%9a%84%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%ef%bc%9a%e4%b8%80%e4%b8%aa%e4%b8%8d%e6%96%ad-2","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/08\/14\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac35%e7%ab%a0-%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%e7%9a%84%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%ef%bc%9a%e4%b8%80%e4%b8%aa%e4%b8%8d%e6%96%ad-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c35\u7ae0 \u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\uff1a\u4e00\u4e2a\u4e0d\u65ad\u53d1\u5c55\u7684\u9886\u57df\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c35\u7ae0 \u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\uff1a\u4e00\u4e2a\u4e0d\u65ad\u53d1\u5c55\u7684\u9886\u57df\uff08\u4e0a\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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35.3  \u80bf\u7624\u75ab\u82d7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u901a\u8fc7\u964d\u4f4e\u6291\u5236\u6027\u514d\u75ab\u4fe1\u53f7\u6765\u589e\u5f3a\u73b0\u6709\u7684\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u800c\u75ab\u82d7\u7684\u4f5c\u7528\u673a\u5236\u5219\u6709\u6240\u4e0d\u540c\uff0c\u5176\u76ee\u7684\u662f\u6fc0\u53d1\u5e76\u8bf1\u5bfc\u65b0\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u75ab\u82d7\u7684\u4e3b\u8981\u4f5c\u7528\u5728\u4e8e\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08\u5982\u6811\u7a81\u72b6\u7ec6\u80de\uff0cDCs\uff09\u7684\u6c34\u5e73\u3002DCs\u6444\u53d6\u5e76\u5904\u7406\u6297\u539f\uff0c\u7136\u540e\u5c06\u5176\u4e0e\u589e\u5f3aCD8 T\u7ec6\u80de\u5e94\u7b54\u7684\u5171\u523a\u6fc0\u5206\u5b50\u4e00\u8d77\u63d0\u5448\u7ed9\u7ec6\u80de\u6bd2\u6027CD8 T\u7ec6\u80de\u3002\u8fd9\u4e9bT\u7ec6\u80de\u8bc6\u522bMHC\u5206\u5b50\u80cc\u666f\u4e0b\u5448\u9012\u7684\u5c0f\u80bd\u7247\u6bb5\uff0c\u901a\u8fc7\u5176T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u8bc6\u522b\u6297\u539f\uff0c\u4ece\u800c\u6fc0\u6d3bT\u7ec6\u80de\u3002\u6d3b\u5316\u540e\u7684CD8 T\u7ec6\u80de\u4f1a\u589e\u6b96\u3001\u5e7f\u6cdb\u8fc1\u79fb\uff0c\u5e76\u80fd\u591f\u7279\u5f02\u6027\u5730\u653b\u51fb\u8868\u8fbe\u5176\u540c\u6e90\u80bd\/MHC\u914d\u4f53\u7684\u9776\u7ec6\u80de\u3002<\/p>\n

\u6811\u7a81\u72b6\u7ec6\u80de\u662f\u6700\u6709\u6548\u7684\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08APC\uff09\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0d\u4ec5\u80fd\u591f\u542f\u52a8\u521d\u59cbT\u7ec6\u80de\u53cd\u5e94\uff0c\u8fd8\u80fd\u54cd\u5e94\u56fa\u6709\u514d\u75ab\u4fe1\u53f7\uff0c\u534f\u8c03\u6574\u4f53\u514d\u75ab\u53cd\u5e94\u3002\u56e0\u6b64\uff0c\u764c\u75c7\u75ab\u82d7\u901a\u5e38\u5305\u542b\u4e00\u79cd\u4f50\u5242\u548c\u4e00\u79cd\u80bf\u7624\u7279\u5f02\u6027\u80bd\u6216\u86cb\u767d\uff0c\u4f50\u5242\u7684\u4f5c\u7528\u662f\u6fc0\u6d3b\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u4f7f\u5176\u80fd\u591f\u6709\u6548\u5730\u5411T\u7ec6\u80de\u5448\u9012\u6297\u539f\u5e76\u63d0\u4f9b\u5fc5\u8981\u7684\u5171\u523a\u6fc0\u4fe1\u53f7\u3002<\/p>\n

\u524d\u5217\u817a\u764c\u7531\u4e8e\u8868\u8fbe\u591a\u79cd\u7279\u5f02\u6027\u80bf\u7624\u6297\u539f\uff0c\u5982\u524d\u5217\u817a\u9178\u6027\u78f7\u9178\u9176\uff08PAP\uff09\u3001\u524d\u5217\u817a\u7279\u5f02\u6027\u819c\u6297\u539f\uff08PSMA\uff09\u548c\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\uff08PSA\uff09\uff0c\u6210\u4e3a\u75ab\u82d7\u5f00\u53d1\u7684\u7406\u60f3\u5019\u9009\u5bf9\u8c61\u3002\u8fd9\u4e9b\u6297\u539f\u4e3b\u8981\u5728\u524d\u5217\u817a\u4e2d\u9ad8\u8868\u8fbe\uff0c\u56e0\u6b64\u901a\u8fc7\u75ab\u82d7\u5f3a\u6709\u529b\u5730\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u53ef\u4ee5\u5728\u7406\u8bba\u4e0a\u964d\u4f4e\u8bef\u4f24\u5176\u4ed6\u7ec4\u7ec7\u7684\u98ce\u9669\u3002\u6b64\u5916\uff0c\u60a3\u6709\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u7684\u7537\u6027\u901a\u5e38\u5df2\u63a5\u53d7\u4e86\u653e\u7597\u6216\u624b\u672f\u7684\u521d\u6b65\u6cbb\u7597\uff0c\u56e0\u6b64\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0c\u524d\u5217\u817a\u6297\u539f\u7684\u552f\u4e00\u6765\u6e90\u53ef\u80fd\u5c31\u662f\u80bf\u7624\u672c\u8eab\uff0c\u4f7f\u5f97\u75ab\u82d7\u7684\u9776\u5411\u6027\u66f4\u4e3a\u660e\u786e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f8e\u56fdFDA\u6279\u51c6\u7684\u552f\u4e00\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u75ab\u82d7\u662fSipuleucel-T\uff0c\u8fd9\u662f\u4e00\u79cd\u7531\u60a3\u8005\u81ea\u8eab\u7ec6\u80de\u5236\u5907\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u75ab\u82d7\u3002\u5176\u5236\u5907\u8fc7\u7a0b\u5305\u62ec\u5206\u79bb\u60a3\u8005\u7684\u5355\u6838\u7ec6\u80de\uff0c\u5e76\u5c06\u8fd9\u4e9b\u7ec6\u80de\u4e0e\u7531\u524d\u5217\u817a\u9178\u6027\u78f7\u9178\u9176\uff08PAP\uff09\u548c\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\uff09\u7ec4\u6210\u7684\u878d\u5408\u86cb\u767d\u5171\u57f9\u517b\uff0c\u4ece\u800c\u8bf1\u5bfc\u5355\u6838\u7ec6\u80de\u6210\u719f\u4e3a\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u5e76\u6fc0\u6d3b\u8fd9\u4e9b\u7ec6\u80de\uff0c\u5c06PAP\u4f5c\u4e3a\u9776\u6297\u539f\u3002\u5f53\u8fd9\u4e9b\u88ab\u6fc0\u6d3b\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u56de\u8f93\u5230\u60a3\u8005\u4f53\u5185\u540e\uff0c\u6297\u539f\u88ab\u5448\u9012\u5230MHC I\u548cII\u5206\u5b50\u4e0a\uff0c\u4ece\u800c\u6f5c\u5728\u5730\u8bf1\u5bfc\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u53cd\u5e94\uff0c\u5e76\u4fc3\u8fdb\u4f53\u6db2\u514d\u75ab\u6548\u5e94\u7684\u4ea7\u751f\u3002<\/p>\n

\u5728\u524d\u5217\u817a\u817a\u764c\u514d\u75ab\u6cbb\u7597\u7814\u7a76\uff08IMPACT\uff09\u4e2d\uff0c\u6570\u636e\u663e\u793a\u63a5\u53d7Sipuleucel-T\u6cbb\u7597\u7684\u60a3\u8005\u7684\u5e73\u5747\u603b\u4f53\u751f\u5b58\u671f\uff08OS\uff09\u5ef6\u957f\u4e864.1\u4e2a\u6708\uff0cSipuleucel-T\u7ec4\u7684OS\u4e3a25.8\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a21.7\u4e2a\u6708\u3002\u7136\u800c\uff0c\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u4ec5\u67092.6%\u7684\u4ebaPSA\u6c34\u5e73\u4e0b\u964d\u8d85\u8fc750%\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u60a3\u8005\u4e0d\u4ec5\u8840\u6e05\u4e2d\u9488\u5bf9PAP\u7684\u6297\u4f53\u663e\u8457\u589e\u52a0\uff0c\u8fd8\u5bf9\u5176\u4ed6\u6297\u539f\u5982LGALS3\u548cECE1\uff08\u5df2\u77e5\u5728\u539f\u53d1\u80bf\u7624\u4e2d\u8868\u8fbe\u7684\u6297\u539f\uff09\u7684\u6297\u4f53\u4e5f\u663e\u8457\u589e\u52a0\u3002\u8fd9\u79cd\u73b0\u8c61\u88ab\u79f0\u4e3a\u201c\u6297\u539f\u6269\u6563\u201d\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u514d\u75ab\u4ecb\u5bfc\u7684\u764c\u7ec6\u80de\u653b\u51fb\u5bfc\u81f4\u5728\u4fc3\u514d\u75ab\u539f\u6027\u73af\u5883\u4e2d\u91ca\u653e\u989d\u5916\u6297\u539f\u6240\u5f15\u53d1\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3d\u7ba1Sipuleucel-T\u5728III\u671f\u8bd5\u9a8c\u4e2d\u8868\u73b0\u51fa\u7597\u6548\uff0c\u4f46\u53e6\u4e00\u79cd\u7528\u4e8e\u524d\u5217\u817a\u764c\u7684\u75ab\u82d7\u5728III\u671f\u8bd5\u9a8c\u4e2d\u7684\u7ed3\u679c\u5374\u4e0d\u5c3d\u5982\u4eba\u610f\u3002GVAX\u524d\u5217\u817a\u75ab\u82d7\u662f\u4e00\u79cd\u5168\u7ec6\u80de\u75ab\u82d7\uff0c\u7531\u4e24\u4e2a\u80bf\u7624\u7ec6\u80de\u7cfb\uff08PC3\u548cLNCaP\uff09\u7ec4\u6210\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7cfb\u7ecf\u91cd\u7ec4\u75c5\u6bd2\u8f7d\u4f53\u8f6c\u5bfc\u540e\u80fd\u591f\u5206\u6cccGM-CSF\u30022006\u5e74\uff0c\u4e00\u9879\u5728mCRPC\u60a3\u8005\u4e2d\u6bd4\u8f83GVAX\u524d\u5217\u817a\u75ab\u82d7\u4e0e\u5316\u7597\u7684\u968f\u673aIII\u671f\u8bd5\u9a8c\u62db\u52df\u4e86\u7ea6600\u540d\u60a3\u8005\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u4e0eSipuleucel-T\u8bd5\u9a8c\u6216\u6b63\u5728\u8fdb\u884c\u7684Prostvac-VF III\u671f\u8bd5\u9a8c\uff08\u89c1\u4e0b\u6587\uff09\u4e0d\u540c\uff0c\u8fd9\u9879\u8bd5\u9a8c\u4f7f\u7528\u4e86\u591a\u897f\u4ed6\u8d5b\u5316\u7597\u4f5c\u4e3a\u6d3b\u6027\u5bf9\u7167\uff0c\u800c\u591a\u897f\u4ed6\u8d5b\u5316\u7597\u5728mCRPC\u4e2d\u5177\u6709\u660e\u786e\u7684\u4e34\u5e8a\u76ca\u5904\u3002\u7136\u800c\uff0c\u7531\u4e8e\u65e0\u6548\u6027\u5206\u6790\uff08futility analysis\uff09\u663e\u793a\u8fbe\u5230\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u7684\u6982\u7387\u4f4e\u4e8e30%\uff0c\u8be5\u8bd5\u9a8c\u63d0\u524d\u7ec8\u6b62\u3002<\/p>\n

\u5c3d\u7ba1\u5982\u6b64\uff0c\u76ee\u524d\u4ecd\u5728\u8fdb\u884cGVAX\u4e0e\u5176\u4ed6\u6cbb\u7597\u8054\u5408\u5e94\u7528\u7684\u7814\u7a76\uff0c\u5305\u62ec\u5728II\u671f\u8bd5\u9a8c\u4e2d\u5c06\u5176\u4e0e\u65b0\u8f85\u52a9\u6fc0\u7d20\u6cbb\u7597\u76f8\u7ed3\u5408\u7684\u7814\u7a76 (Table 35.2)<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 35.2<\/span> \u5165\u9009\u4e34\u5e8a\u8bd5\u9a8c\u7684\u524d\u5217\u817a\u764c\u75ab\u82d7\u540d\u79f0<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53e6\u4e00\u79cd\u6b63\u5728\u7814\u53d1\u7684\u524d\u5217\u817a\u764c\u75ab\u82d7\u662fProstvac-VF\uff08\u7531Bavarian Nordic\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u5317\u5361\u7f57\u6765\u7eb3\u5ddeMorrisville\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u4e24\u90e8\u5206\u7ec4\u6210\u7684\u75c5\u6bd2\u75ab\u82d7\uff0c\u5305\u62ec\u521d\u6b21\u63a5\u79cd\uff08Prostvac-V\uff09\u548c\u52a0\u5f3a\u63a5\u79cd\uff08Prostvac-F\uff09\uff0c\u5176\u4e3b\u8981\u9776\u5411\u6297\u539f\u662f\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\uff08PSA\uff09(Table 35.2)<\/span>\u3002\u6b64\u5916\uff0cProstvac-VF\u8fd8\u5305\u542bTRICOM\u2122\uff0c\u8fd9\u662f\u4e00\u79cd\u5171\u523a\u6fc0\u5206\u5b50\u7ec4\u5408\uff08B7.1\u3001ICAM-1\u548cLFA-3\uff09\uff0c\u65e8\u5728\u589e\u5f3a\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08APC\uff09\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u3002<\/p>\n

Prostvac-VF\u5728\u2161\u671f\u8bd5\u9a8c\u4e2d\u672a\u80fd\u8fbe\u5230\u9884\u8bbe\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7ec8\u70b9\uff0c\u4f46\u4e8b\u540e\u5206\u6790\u663e\u793a\uff0c\u57283\u5e74\u968f\u8bbf\u65f6\uff0c\u8be5\u75ab\u82d7\u4f3c\u4e4e\u5c06\u603b\u4f53\u751f\u5b58\u671f\u5ef6\u957f\u4e868.5\u4e2a\u6708\uff0c\u4ece16.6\u4e2a\u6708\u5ef6\u957f\u81f325.1\u4e2a\u6708\u3002\u76ee\u524d\uff0cProstvac\u8054\u5408GM-CSF\u6cbb\u7597mCRPC\u60a3\u8005\u7684\u2162\u671f\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d(Table 35.2)<\/span>\u3002\u8fd9\u9879\u751f\u5b58\u671f\u8bd5\u9a8c\u5c061,200\u540d\u672a\u63a5\u53d7\u5316\u7597\u7684mCRPC\u7537\u6027\u60a3\u8005\u968f\u673a\u5206\u4e3a\u4e09\u7ec4\uff0c\u5206\u522b\u63a5\u53d7\u5b89\u6170\u5242\u3001Prostvac-VF\u8054\u5408\u76ae\u5185GM-CSF\u6216Prostvac-VF\u8054\u5408\u5b89\u6170\u5242\uff08NCT01322490\uff09\u3002\u8be5\u8bd5\u9a8c\u6392\u9664\u4e86\u5185\u810f\u8f6c\u79fb\u7684\u60a3\u8005\u3002\u867d\u7136\u60a3\u8005\u7684\u62db\u52df\u5df2\u7ecf\u5b8c\u6210\uff0c\u4f46\u6700\u7ec8\u7ed3\u679c\u5c1a\u672a\u516c\u5e03\u3002\u6b64\u5916\uff0cProstvac\u4e0e\u6297CTLA-4\u4ee5\u53ca\u5176\u4ed6\u836f\u7269\u7684\u8054\u5408\u8bd5\u9a8c\u4e5f\u5728\u8fdb\u884c\u4e2d\uff0c\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff0c30\u540d\u60a3\u8005\u4e2d\u670914\u540d\u7684PSA\u6c34\u5e73\u6709\u6240\u4e0b\u964d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

DNA\u75ab\u82d7\u662f\u53e6\u4e00\u9879\u7528\u4e8e\u524d\u5217\u817a\u764c\u7684\u6280\u672f\uff0c\u6b63\u5728\u8fdb\u884cI\u671f\u548cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u901a\u5e38\uff0c\u8fd9\u4e9b\u75ab\u82d7\u7531\u7f16\u7801\u9776\u5411\u6297\u539f\u7684\u7ec6\u83cc\u8d28\u7c92\u6784\u6210\uff1b\u5f53\u901a\u8fc7\u808c\u8089\u6ce8\u5c04\u7ed9\u60a3\u8005\u540e\uff0c\u7f16\u7801\u7684\u86cb\u767d\u8d28\u901a\u8fc7\u5bbf\u4e3b\u7ec6\u80de\u7684\u8f6c\u5f55\u673a\u5236\u8868\u8fbe\u3002\u8fd9\u4e9b\u6297\u539f\u968f\u540e\u88ab\u6811\u7a81\u72b6\u7ec6\u80de\u5904\u7406\u548c\u5448\u9012\uff0c\u53ef\u80fd\u5bfc\u81f4\u6dcb\u5df4\u7ec6\u80de\u7684\u52a8\u5458\u548c\u6fc0\u6d3b\u3002\u6b64\u5916\uff0c\u7ec6\u83cc\u8d28\u7c92\u4e0a\u7684\u4f4e\u7532\u57fa\u5316CpG\u57fa\u5e8f\u80fd\u591f\u6fc0\u6d3b\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u7684\u75c5\u539f\u4f53\u8bc6\u522b\u53d7\u4f53\uff0c\u5982TLR9\u548ccGAS\uff0c\u5305\u62ec\u6811\u7a81\u72b6\u7ec6\u80de\u3001B\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u3002\u8fd9\u4e9b\u53d7\u4f53\u4e0b\u6e38\u7684\u4fe1\u53f7\u4f20\u5bfc\u7ea7\u8054\u53cd\u5e94\u5f15\u53d1\u4fc3\u708e\u6548\u5e94\uff0c\u5305\u62ecGM-CSF\u7684\u4ea7\u751f\u4ee5\u4fc3\u8fdb\u5355\u6838\u7ec6\u80de\u7684\u6210\u719f\uff0c\u4ee5\u53caI\u578b\u5e72\u6270\u7d20\u7684\u4ea7\u751f\u4ee5\u589e\u5f3aB\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u6d3b\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5982\u524d\u6240\u8ff0\uff0c\u524d\u5217\u817a\u764c\u7ec6\u80de\u8868\u8fbe\u4e00\u7ec4\u5171\u540c\u7684\u80bf\u7624\u6297\u539f\uff0c\u56e0\u6b64\u5b83\u4eec\u662fDNA\u75ab\u82d7\u7684\u7406\u60f3\u5019\u9009\u3002\u9488\u5bf9\u524d\u5217\u817a\u764c\uff0c\u5df2\u6709\u591a\u79cdDNA\u75ab\u82d7\u5f00\u53d1\u5b8c\u6210\u5e76\u5904\u4e8e\u4e0d\u540c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u6700\u5177\u8fdb\u5c55\u7684\u662fMVI-816\uff08\u7531\u9ea6\u8fea\u900a\u75ab\u82d7\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u5a01\u65af\u5eb7\u661f\u5dde\u9ea6\u8fea\u900a\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u7f16\u7801PAP\u7684DNA\u75ab\u82d7\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u2161\u671f\u8bd5\u9a8c\u3002\u5728\u8fd9\u9879\u8bd5\u9a8c\u4e2d\uff0c\u975e\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u88ab\u968f\u673a\u5206\u7ec4\uff0c\u5206\u522b\u63a5\u53d7MVI-816\u8054\u5408GM-CSF\u6cbb\u7597\u6216\u5355\u72ec\u63a5\u53d7GM-CSF\u6cbb\u7597\uff0c\u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u8f6c\u79fb\u751f\u5b58\u671f\uff08NCT01341652\uff09\u3002<\/p>\n

\u7531\u4e8e\u665a\u671f\u764c\u75c7\u60a3\u8005\u7684\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u4e9a\u7fa4\u53ef\u80fd\u8868\u8fbe\u9ad8\u6c34\u5e73\u7684PD-1\uff0c\u56e0\u6b64\u4ec5\u9760DNA\u75ab\u82d7\u53ef\u80fd\u4e0d\u8db3\u4ee5\u6709\u6548\u6fc0\u6d3b\u8fd9\u4e9b\u8017\u7aed\u7684T\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u5728\u4e00\u9879\u9488\u5bf9mCRPC\u60a3\u8005\u7684I\u671f\u8bd5\u9a8c\u4e2d\uff0cMVI-816\u6b63\u5728\u4e0ePD-1\u6291\u5236\u5242\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u4f7f\u7528\uff0c\u4e3b\u8981\u7ec8\u70b9\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3001\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u3001\u5f71\u50cf\u5b66\u8fdb\u5c55\u65f6\u95f4\u548cPSA\u7f13\u89e3\u7387 (Table.35.1)<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 35.1<\/span> <\/span>\u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u8bd5\u9a8c<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u79cd\u5f15\u4eba\u6ce8\u76ee\u7684DNA\u75ab\u82d7\u7b56\u7565\u9776\u5411\u524d\u5217\u817a\u7279\u5f02\u6027\u819c\u6297\u539f\uff08PSMA\uff09\u548c\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\uff08PSA\uff09\u3002\u8fd9\u79cd\u75ab\u82d7\u7684\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\uff0c\u5b83\u5e76\u4e0d\u7f16\u7801\u5929\u7136\u86cb\u767d\u8d28\uff0c\u800c\u662f\u7f16\u7801\u7ecf\u8fc7\u8f7b\u5fae\u4fee\u6539\u7684\u7248\u672c\uff0c\u8fd9\u4e9b\u7248\u672c\u4e0e\u5929\u7136\u6297\u539f\u76f8\u6bd4\u5728\u81ea\u7136\u754c\u4e2d\u66f4\u5177\u5f02\u79cd\u6027\uff0c\u4ece\u800c\u589e\u5f3a\u5bf9\u5929\u7136\u6297\u539f\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u6b3eDNA\u75ab\u82d7\u540d\u4e3aINO-5150\uff08\u7531Inovio\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5ddePlymouth Meeting\uff09\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5355\u72ec\u4f7f\u7528\u6216\u4e0e\u5176\u7ec6\u80de\u56e0\u5b50\u4f50\u5242IL-12\u8d28\u7c92INO-9012\u8054\u5408\u4f7f\u7528\u3002\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u6807\u662f\u8bc4\u4f30\u75ab\u82d7\u7684\u5b89\u5168\u6027\u548c\u6297\u539f\u7279\u5f02\u6027\u5e94\u7b54 (Table 35.2)<\/span>\u3002\u8be5\u8bd5\u9a8c\u7684\u76ee\u6807\u60a3\u8005\u662f\u65e9\u671f\u524d\u5217\u817a\u764c\u60a3\u8005\uff0c\u5373\u5728\u521d\u6b21\u624b\u672f\u6216\u653e\u7597\u540ePSA\u5347\u9ad8\u7684\u60a3\u8005\u3002\u76ee\u524d\uff0c\u60a3\u8005\u62db\u52df\u5de5\u4f5c\u5df2\u7ecf\u5b8c\u6210\uff0c\u514d\u75ab\u76d1\u6d4b\u6570\u636e\u5c1a\u5f85\u516c\u5e03\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u79cd\u66f4\u76f4\u63a5\u7684\u75ab\u82d7\u63a5\u79cd\u65b9\u6cd5\u662f\u901a\u8fc7\u80bf\u7624\u5185\u6ce8\u5c04\u514d\u75ab\u539f\u6027\u7269\u8d28\uff0c\u4ee5\u589e\u5f3a\u539f\u4f4d\u80bf\u7624\u7684\u514d\u75ab\u539f\u6027\u3002\u5176\u4e2d\u4e00\u79cd\u75ab\u82d7ProstAtak\uff08\u7531Advagene\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u5965\u672c\u4ee3\u5c14\uff09\u76ee\u524d\u6b63\u5728\u524d\u5217\u817a\u764c\u7684\u2162\u671f\u5f00\u53d1\u9636\u6bb5 (Table 35.2)<\/span>\u3002\u8fd9\u6b3e\u75ab\u82d7\u7531\u4e00\u79cd\u51cf\u6bd2\u7684\u817a\u75c5\u6bd2\u7ec4\u6210\uff0c\u5c06\u75b1\u75b9\u75c5\u6bd2\u884d\u751f\u7684\u80f8\u82f7\u6fc0\u9176\uff08tk\uff09\u57fa\u56e0\u6ce8\u5c04\u5230\u80bf\u7624\u5185\uff0c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u8868\u8fbe\u8be5\u57fa\u56e0\u3002\u8fd9\u4f7f\u5f97\u8fd9\u4e9b\u7ec6\u80de\u5bf9\u6807\u51c6\u6297\u75c5\u6bd2\u836f\u7269\u4f10\u6614\u6d1b\u97e6\uff08\u7531\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u82f1\u56fd\u7c73\u5fb7\u5c14\u585e\u514b\u65af\uff09\u975e\u5e38\u654f\u611f\u3002\u836f\u7269\u7ed9\u836f\u4f1a\u5bfc\u81f4\u611f\u67d3\u7684\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\uff0c\u540c\u65f6\u91ca\u653e\u80bf\u7624\u6297\u539f\u3002\u867d\u7136FDA\u5df2\u6279\u51c6\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u7624\u5185\u75ab\u82d7\uff0c\u4f46\u5728\u524d\u5217\u817a\u764c\u4e2d\u8fdb\u884c\u53cd\u590d\u7684\u7624\u5185\u6ce8\u5c04\u589e\u52a0\u4e86\u64cd\u4f5c\u590d\u6742\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u79cd\u75ab\u82d7\u7b56\u7565\u662f\u5229\u7528\u9ad8\u9759\u6c34\u538b\u529b\uff08HHP\uff09\u4f7f\u80bf\u7624\u7ec6\u80de\u5931\u6d3b\uff0c\u4ece\u800c\u4fdd\u7559\u5176\u6297\u539f\u6027\u3002\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5f53\u6811\u7a81\u72b6\u7ec6\u80de\u66b4\u9732\u4e8e\u8fd9\u4e9bHHP\u5931\u6d3b\u7684\u80bf\u7624\u7ec6\u80de\u65f6\uff0cIL-12\u7684\u4ea7\u751f\u548c\u6210\u719f\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u6548\u679c\u4f18\u4e8e\u66b4\u9732\u4e8e\u8f90\u5c04\u706d\u6d3b\u80bf\u7624\u7ec6\u80de\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u5f53\u8fd9\u79cd\u75ab\u82d7\u4e0e\u591a\u897f\u4ed6\u8d5b\u8054\u5408\u7528\u4e8e\u514d\u75ab\u539f\u6027\u8f83\u4f4e\u7684\u5c0f\u9f20TRAMP-C2\u80bf\u7624\u65f6\uff0c\u7ed3\u679c\u663e\u793a\u80bf\u7624\u751f\u957f\u51cf\u7f13\u4e14\u751f\u5b58\u7387\u63d0\u9ad8\u3002<\/p>\n

\u57fa\u4e8emRNA\u7684\u75ab\u82d7CV9104\uff08\u7531CureVac\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u5fb7\u56fd\u56fe\u5bbe\u6839\uff09\u5c06\u514d\u75ab\u523a\u6fc0\u6027\u9c7c\u7cbe\u86cb\u767d\u4e0e\u7f16\u7801PSA\u3001PSMA\u3001PSCA\u548cSTEAP\u7684mRNA\u7ed3\u5408 (Table 35.2)<\/span>\u3002mRNA\u75ab\u82d7\u5177\u6709\u51cf\u5c11\u6784\u5efa\u4f53\u6574\u5408\u5165\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u7684\u98ce\u9669\uff0c\u8fd9\u5728\u4f7f\u7528DNA\u75ab\u82d7\u65f6\u53ef\u80fd\u662f\u4e00\u4e2a\u95ee\u9898\u3002\u5c3d\u7ba1\u2160\u671f\u548c\u2161a\u671f\u8bd5\u9a8c\u7684\u521d\u6b65\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u4f46\u5728\u2161b\u671f\u8bd5\u9a8c\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u8be5\u75ab\u82d7\u672a\u80fd\u663e\u8457\u6539\u5584\u603b\u4f53\u751f\u5b58\u671f\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

\u4f7f\u7528\u706d\u6d3b\u7ec6\u83cc\u8fdb\u884c\u75ab\u82d7\u63a5\u79cd\u662f\u6700\u53e4\u8001\u7684\u75ab\u82d7\u63a5\u79cd\u5f62\u5f0f\u4e4b\u4e00\uff0c\u5e76\u4e14\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u4e5f\u6709\u5e94\u7528\u3002\u5176\u4e2d\u4e00\u79cd\u7279\u522b\u5f15\u4eba\u6ce8\u76ee\u7684\u75ab\u82d7\u8f7d\u4f53\u662f\u9633\u6027\u7ec6\u83cc\u5355\u6838\u7ec6\u80de\u589e\u751f\u674e\u65af\u7279\u83cc\uff08Lm\uff09\u3002Lm\u53ef\u4ee5\u76f4\u63a5\u611f\u67d3\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff0c\u4fc3\u4f7f\u5176\u8868\u8fbe\u6297\u539f\u5e76\u901a\u8fc7I\u7c7bMHC\u5206\u5b50\u8fdb\u884c\u5448\u9012\u3002\u56e0\u6b64\uff0c\u57fa\u4e8eLm\u7684\u75ab\u82d7\u80fd\u591f\u8bf1\u5bfc\u5f3a\u70c8\u7684\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u3002\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\uff0cLm\u7684\u91cd\u7ec4\u682a\u53ef\u4ee5\u8868\u8fbe\u5916\u6e90\u6297\u539f\uff0c\u5305\u62ec\u80bf\u7624\u6297\u539f\u3002\u867d\u7136\u672a\u7ecf\u4fee\u9970\u7684Lm\u5177\u6709\u6bd2\u6027\uff0c\u4f46\u4e34\u5e8a\u4f7f\u7528\u7684\u75ab\u82d7\u91c7\u7528\u4e86\u591a\u79cd\u65b9\u6cd5\u6765\u964d\u4f4e\u5176\u81f4\u75c5\u6027\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u57fa\u56e0\u6572\u9664ActA\u548cInlB\u57fa\u56e0\uff0c\u8fd9\u4e24\u79cd\u57fa\u56e0\u5206\u522b\u4e0e\u7ec6\u80de\u95f4\u6269\u6563\u548c\u809d\u810f\u5f52\u5de2\u6709\u5173\u3002\u6572\u9664\u8fd9\u4e9b\u57fa\u56e0\u7684\u83cc\u682a\u81f4\u6b7b\u6027\u964d\u4f4e\u4e86\u7ea6\u56db\u4e2a\u5bf9\u6570\u5355\u4f4d\uff0c\u4ece\u800c\u53ef\u4ee5\u5728\u589e\u52a0\u5242\u91cf\u7684\u540c\u65f6\u589e\u5f3a\u6297\u539f\u6027\u3002<\/p>\n

\u8fd9\u79cd\u65b9\u6cd5\u5df2\u7ecf\u5e94\u7528\u4e8e\u524d\u5217\u817a\u764c\u7684\u2160\u671f\u8bd5\u9a8c\u4e2d\uff0c\u4f7f\u7528\u7684\u662f\u4e00\u79cd\u51cf\u6bd2\u6d3b\u53cc\u5220\u9664\uff08LADD\uff09\u75ab\u82d7\u682aADU-741\uff08\u7531Aduro Biotech\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u4f2f\u514b\u5229\uff09(Table 35.2)<\/span>\u3002\u8be5\u75ab\u82d7\u682a\u7684\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\uff0c\u5b83\u540c\u65f6\u7f16\u7801\u56db\u79cd\u4e0e\u524d\u5217\u817a\u76f8\u5173\u7684\u6297\u539f\uff1aPSMA\u3001PAP\u3001\u764c\u6297\u539fSSX2\u548c\u524d\u5217\u817a\u76f8\u5173\u8f6c\u5f55\u56e0\u5b50NKX3.1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u79cd\u51cf\u6bd2\u65b9\u6cd5\u662f\u901a\u8fc7\u6572\u9664\u674e\u65af\u7279\u83cc\u88c2\u89e3\u7d20O\uff08LLO\uff09\u57fa\u56e0\uff0c\u4ece\u800c\u963b\u6b62\u674e\u65af\u7279\u83cc\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u7684\u7ec6\u80de\u8d28\u3002\u8fd9\u79cd\u65b9\u6cd5\u7531Advaxis\u516c\u53f8\uff08\u4f4d\u4e8e\u65b0\u6cfd\u897f\u5dde\u666e\u6797\u65af\u987f\uff09\u5f00\u53d1\uff0c\u5e76\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u6b63\u5728\u8fdb\u884c\u4e0e\u6297PD-1\u6297\u4f53\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u4f7f\u7528\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u57fa\u4e8eLm\u7684\u75ab\u82d7\u5df2\u88ab\u8bc1\u660e\u80fd\u591f\u51cf\u5c11\u80bf\u7624\u73af\u5883\u4e2d\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u8fd9\u4e9b\u8c03\u8282\u6027T\u7ec6\u80de\u901a\u8fc7\u5206\u6ccc\u514d\u75ab\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u6291\u5236\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08APC\uff09\u7684\u529f\u80fd\uff0c\u524a\u5f31T\u7ec6\u80de\u7684\u514d\u75ab\u5e94\u7b54\u3002\u6b64\u5916\uff0c\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u6027\u7ec6\u80de\uff08MDSCs\uff09\u4e5f\u901a\u8fc7\u4ea7\u751f\u7c7b\u4f3c\u7684\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u4fc3\u6210\u80bf\u7624\u73af\u5883\u4e2d\u7684\u9ad8\u5ea6\u6291\u5236\u6027\u72b6\u6001\u3002\u5728\u57fa\u4e8eLm\u7684\u6297\u80bf\u7624\u75ab\u82d7\u6a21\u578b\u4e2d\uff0cMDSCs\u7684\u6570\u91cf\u548c\u6291\u5236\u80fd\u529b\u4e5f\u663e\u8457\u964d\u4f4e\u3002<\/p>\n

\u674e\u65af\u7279\u83cc\u5929\u7136\u7684\u514d\u75ab\u523a\u6fc0\u7279\u6027\u4ee5\u53ca\u5176\u6613\u4e8e\u57fa\u56e0\u64cd\u4f5c\u7684\u7279\u6027\uff0c\u4f7f\u5176\u6210\u4e3a\u5f00\u53d1\u7528\u4e8e\u665a\u671f\u80bf\u7624\uff08\u5982mCRPC\uff09\u75ab\u82d7\u7684\u6709\u529b\u5de5\u5177\uff0c\u5c24\u5176\u662f\u5728\u9488\u5bf9\u5177\u6709\u7279\u5b9a\u5fae\u73af\u5883\u7684\u80bf\u7624\u65f6\u5c55\u73b0\u51fa\u5f88\u5927\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

35.4  \u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5e7f\u6cdb\u7684\u6297\u80bf\u7624\u6cbb\u7597\u5e76\u4e0d\u603b\u662f\u5bf9\u6bcf\u4f4d\u60a3\u8005\u90fd\u6709\u6548\uff0c\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u6b63\u5728\u52aa\u529b\u5f00\u53d1\u9488\u5bf9\u4e2a\u4f53\u80bf\u7624\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6cd5\u3002\u8fc7\u7ee7\u6027\u7ec6\u80de\u6cbb\u7597\uff08ACT\uff09\u662f\u4e00\u79cd\u4ece\u60a3\u8005\u4f53\u5185\u5206\u79bb\u51fa\u7ec6\u80de\uff08\u901a\u5e38\u662f\u6dcb\u5df4\u7ec6\u80de\uff09\u5e76\u8fdb\u884c\u57fa\u56e0\u64cd\u4f5c\uff0c\u7136\u540e\u518d\u56de\u8f93\u5230\u60a3\u8005\u4f53\u5185\u7684\u6280\u672f\u3002\u8fd9\u79cd\u57fa\u56e0\u64cd\u4f5c\u5305\u62ec\u8f6c\u5bfc\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u53d7\u4f53\u57fa\u56e0\u6216\u5f15\u5165\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u3002CAR T\u7ec6\u80de\u8868\u8fbe\u4e0e\u4e0b\u6e38\u6fc0\u6d3b\u590d\u5408\u7269\uff08\u5982CD3-\u03b6\uff09\u8fde\u63a5\u7684\u6297\u4f53\u91cd\u94fe\u548c\u8f7b\u94fe\uff0c\u4f7f\u5176\u5728\u4e0d\u4f9d\u8d56\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\uff08MHC\uff09\u80cc\u666f\u7684\u60c5\u51b5\u4e0b\u88ab\u6fc0\u6d3b\uff0c\u540c\u65f6\u4fdd\u6301\u6297\u539f\u7279\u5f02\u6027\u3002<\/p>\n

\u76ee\u524d\uff0c\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u7814\u7a76PSMA\u7279\u5f02\u6027CAR T\u7ec6\u80de\u5728mCRPC\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff0c\u4e3b\u8981\u8bc4\u4f30\u5176\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff08NCT01140373\uff09\u3002\u5728\u6700\u8fd1\u7684\u4e00\u9879\u76f8\u5173\u2160\/\u2161\u671f\u8bd5\u9a8c\u4e2d\uff0c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u63a5\u53d7\u4e86NY-ESO-1\u7279\u5f02\u6027TCR\u5de5\u7a0b\u5316T\u7ec6\u80de\u6cbb\u7597\uff0c\u5176\u4e2d70%\u7684\u60a3\u8005\u8fbe\u5230\u4e86\u63a5\u8fd1\u5b8c\u5168\u7f13\u89e3\u6216\u5b8c\u5168\u7f13\u89e3\u7684\u6548\u679c\u3002\u8fd9\u4e00\u53d1\u73b0\u5c24\u4e3a\u91cd\u8981\uff0c\u56e0\u4e3aNY-ESO-1\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u777e\u4e38\u764c\u6297\u539f\uff0c\u5728\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u90fd\u6709\u8868\u8fbe\uff0c\u5305\u62ec\u524d\u5217\u817a\u764c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
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35.5 \u6297\u80bf\u7624\u6297\u4f53<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\u8fc7\u7ee7\u6027\u7ec6\u80de\u7597\u6cd5\u7684\u4e00\u4e2a\u6f5c\u5728\u7f3a\u70b9\u662f\u6240\u63d0\u4f9b\u7684\u7ec6\u80de\u53ef\u80fd\u5177\u6709\u8f83\u957f\u7684\u5bff\u547d\uff0c\u8fd9\u5728\u957f\u671f\u6bd2\u6027\u65b9\u9762\u5e26\u6765\u4e86\u4e00\u5b9a\u7684\u6311\u6218\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u57fa\u4e8e\u6297\u4f53\u7684\u7597\u6cd5\u53ef\u4ee5\u5bf9\u80bf\u7624\u6297\u539f\u5c55\u73b0\u76f8\u540c\u7684\u7279\u5f02\u6027\uff0c\u540c\u65f6\u5177\u6709\u8f83\u77ed\u534a\u8870\u671f\u7684\u4f18\u52bf\u3002\u5728\u524d\u5217\u817a\u764c\u6cbb\u7597\u4e2d\uff0c\u6700\u4e3a\u6210\u719f\u7684\u6297\u80bf\u7624\u6297\u4f53\u662fJ591\uff0c\u8fd9\u662f\u4e00\u79cd\u9776\u5411PSMA\u7684\u6297\u4f53\u3002\u4f5c\u4e3a\u4e00\u79cd\u4eba\u6e90IgG1\u6297\u4f53\uff0cJ591\u88f8\u6297\u4f53\uff08\u672a\u4fee\u9970\u7684\u6297\u4f53\uff09\u6709\u671b\u8bf1\u5bfc\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\uff0c\u5373\u901a\u8fc7\u6297\u4f53\u7684Fc\u90e8\u5206\u4e0e\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684Fc\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\uff0c\u6fc0\u6d3b\u7ec6\u80de\u6bd2\u6027\u7ec6\u80de\uff08\u5982\u5de8\u566c\u7ec6\u80de\u548cNK\u7ec6\u80de\uff09\u3002\u5728\u4eba\u7c7b\u4e2d\uff0c\u8fd9\u901a\u5e38\u662f\u901a\u8fc7IgG1\u4e9a\u578b\u7684\u6297\u4f53\u4e0eNK\u7ec6\u80de\u8868\u9762\u7684Fc\u03b3\u53d7\u4f53\u2162\uff08Fc\u03b3RIII\uff09\u76f8\u4e92\u4f5c\u7528\u5b9e\u73b0\u7684\u3002<\/p>\n

\u5728\u590d\u53d1\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u4e00\u9879\u2161\u671f\u5355\u81c2\u8bd5\u9a8c\u4e2d\uff0cJ591\u4e0eIL-2\u8054\u5408\u4f7f\u7528\uff0c\u663e\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u4e14\u8bd5\u9a8c\u961f\u5217\u7684\u751f\u5b58\u671f\u8d85\u8fc7\u4e86Halabi\u6a21\u578b\u7684\u9884\u671f\uff0c\u63d0\u793a\u53ef\u80fd\u5b58\u5728\u957f\u671f\u751f\u5b58\u83b7\u76ca\u3002\u6b64\u5916\uff0cJ591\u8fd8\u88ab\u7ed3\u5408\u653e\u5c04\u6027\u540c\u4f4d\u7d20\uff0c\u7528\u4e8e\u5c06\u653e\u7597\u9776\u5411\u524d\u5217\u817a\u80bf\u7624\u7ec6\u80de\u3002\u5728\u4e00\u9879\u4f7f\u7528\u653e\u5c04\u6027\u540c\u4f4d\u7d20$^{177}$Lu\u6807\u8bb0\u7684J591\u7684\u2161\u671f\u8bd5\u9a8c\u4e2d\uff0c8\u540d\u60a3\u8005\u7684\u75c5\u60c5\u7a33\u5b9a\uff0c1\u540d\u60a3\u8005\u663e\u793a\u51fa\u5f71\u50cf\u5b66\u90e8\u5206\u7f13\u89e3\u3002\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u8f83\u9ad8\u5242\u91cf\u7684\u6cbb\u7597\u4e0e\u66f4\u957f\u7684\u751f\u5b58\u671f\u76f8\u5173\u3002\u9664\u4e86\u4f5c\u4e3a\u6cbb\u7597\u624b\u6bb5\u5916\uff0cJ591\u7ed3\u5408\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u7684\u80fd\u529b\u8fd8\u4e3a\u80bf\u7624\u6210\u50cf\u63d0\u4f9b\u4e86\u9ad8\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u524d\u5217\u817a\u764c\u7684\u53e6\u4e00\u79cd\u6297\u80bf\u7624\u6297\u4f53\u662f\u9776\u5411B7-H3\u7684\u6297\u4f53\uff0cB7-H3\u5728\u539f\u53d1\u80bf\u7624\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u5e76\u4e14\u4e0e\u8f83\u5dee\u7684\u672f\u540e\u9884\u540e\u663e\u8457\u76f8\u5173\u3002\u4e00\u79cd\u9776\u5411B7-H3\u7684\u88f8\u6297\u4f53\uff08MGA271\uff0c\u7531MacroGenics\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u9a6c\u91cc\u5170\u5ddeGaithersburg\uff09\u76ee\u524d\u6b63\u5904\u4e8e\u2160\u671f\u5f00\u53d1\u9636\u6bb5\uff0c\u53ef\u4ee5\u5355\u72ec\u4f7f\u7528\uff0c\u4e5f\u53ef\u4ee5\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\u6216\u4f0a\u5339\u5355\u6297\u8054\u5408\u4f7f\u7528\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u53cd\u5e94\u7ed3\u679c\uff0c\u6fc0\u53d1\u4e86\u4eba\u4eec\u5bf9\u8fd9\u4e9b\u8bd5\u9a8c\u7684\u5174\u8da3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u79cd\u6709\u8da3\u7684\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u662f\u4f7f\u7528\u7ecf\u8fc7\u5de5\u7a0b\u6539\u9020\u7684\u6297\u4f53\u5c06T\u7ec6\u80de\u5f15\u5bfc\u81f3\u80bf\u7624\u90e8\u4f4d\u3002\u8fd9\u7c7b\u5236\u5242\u901a\u5e38\u5305\u542b\u4e24\u4e2a\u90e8\u5206\uff1a\u4e00\u4e2a\u80bf\u7624\u7279\u5f02\u6027\u6297\u4f53\u90e8\u5206\uff08Fab\uff09\u548c\u4e00\u4e2a\u5bf9T\u7ec6\u80de\u5177\u6709\u7279\u5f02\u6027\u7684\u7b2c\u4e8c\u90e8\u5206\uff08\u901a\u5e38\u662f\u6297CD3\u7684Fab\uff09\u3002\u5176\u673a\u5236\u662f\u5728\u80bf\u7624\u7ed3\u5408\u90e8\u5206\u4e0e\u80bf\u7624\u9776\u70b9\u7ed3\u5408\u7684\u540c\u65f6\uff0c\u6297CD3\u90e8\u5206\u975e\u7279\u5f02\u6027\u5730\u6355\u83b7\u8def\u8fc7\u7684T\u7ec6\u80de\uff0c\u5e76\u5c06\u5176\u5b9a\u5411\u81f3\u80bf\u7624 (Fig.35.4)<\/span>\u3002\u6297\u4f53\u4e0eT\u7ec6\u80de\u8868\u9762\u7684CD3\u5206\u5b50\u7ed3\u5408\u540e\uff0c\u53ef\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u8fdb\u800c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u7684\u6b7b\u4ea1\u3002<\/p>\n

\u9488\u5bf9\u524d\u5217\u817a\u764c\uff0c\u6b63\u5728\u7814\u53d1\u7684\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u6297\u4f53\u662fDART\u2122\u6297\u4f53\uff08MGD009\uff0c\u7531MacroGenics\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u9a6c\u91cc\u5170\u5ddeRockville\uff09\u3002\u8be5\u836f\u7269\u9776\u5411B7-H3\u548cCD3\uff0c\u4f7f\u5176\u80fd\u591f\u5b9a\u4f4d\u81f3\u8868\u8fbeB7-H3\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u5c06T\u7ec6\u80de\u52df\u96c6\u5230\u8be5\u90e8\u4f4d\u5e76\u6fc0\u6d3b\u5b83\u4eec\uff0c\u800c\u4e0d\u8003\u8651\u6297\u539f\u7279\u5f02\u6027 (Fig.35.4)<\/span>\u3002\u7c7b\u4f3c\u7684\u7814\u7a76\u8fd8\u5305\u62ec\u4f7f\u7528\u6297PSMA\u548cCD3\u7684\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u7ed3\u5408\u6297\u4f53\uff08BiTE\u2122\uff0cBAY2010112\uff0c\u7531\u62dc\u8033\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u5fb7\u56fd\u52d2\u6c83\u5e93\u68ee\uff09\uff0c\u76ee\u524d\u6b63\u5904\u4e8e\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff08NCT01723475\uff09\uff0c\u4e3b\u8981\u7814\u7a76\u76ee\u6807\u662f\u786e\u5b9a\u6700\u5927\u8010\u53d7\u5242\u91cf\u548c\u4e0d\u826f\u4e8b\u4ef6\u7684\u6570\u91cf\u3002<\/p>\n

\u6b64\u5916\uff0c\u9488\u5bf9\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u7fa4\u4f53\u7684\u6297\u4f53\u4e5f\u5728\u7814\u53d1\u4e2d\uff0c\u4f8b\u5982AAT-007\uff08\u7531AskAt\u516c\u53f8\u5f00\u53d1\uff0c\u4f4d\u4e8e\u65e5\u672c\u540d\u53e4\u5c4b\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u2161\u671fEP4\u62ee\u6297\u5242\uff08NCT02538432\uff09\u3002\u963b\u65adEP4\u53ef\u4ee5\u6d88\u9664\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u6027\u7ec6\u80de\uff08MDSCs\uff09\u7684\u591a\u79cd\u6291\u5236\u529f\u80fd\uff0c\u8fd9\u4e9b\u529f\u80fd\u901a\u5e38\u4f1a\u524a\u5f31\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 35.4 <\/span>\u901a\u8fc7BiTE\u2122\u6297\u4f53\u6fc0\u6d3bT\u7ec6\u80de\u3002BiTE\u2122\u6216DART\u2122\u6297\u4f53\u901a\u8fc7\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684CD3\u5206\u5b50\uff0c\u4f7fT\u7ec6\u80de\u88ab\u6fc0\u6d3b\u5e76\u5bf9\u8868\u8fbe\u7279\u5b9a\u6297\u539f\uff08\u5982PAP\uff09\u7684\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027\u53cd\u5e94\uff0c\u800c\u65e0\u9700\u8003\u8651T\u7ec6\u80de\u7684TCR\u7279\u5f02\u6027\u3002BiTE\u2122\u6297\u4f53\u7531\u4e00\u4e2a\u591a\u80bd\u94fe\u8fde\u63a5\u4f53\u7ec4\u6210\uff0c\u800cDART\u2122\u6297\u4f53\u5219\u7531\u4e24\u6761\u591a\u80bd\u94fe\u548c\u4e00\u4e2a\u94fe\u95f4\u4e8c\u786b\u952e\u7ec4\u6210\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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35.6 \u603b\u7ed3<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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mCRPC\u662f\u4e00\u79cd\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u8f83\u5c11\u7684\u81f4\u547d\u6027\u75be\u75c5\uff0c\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u5f80\u5f80\u4e0d\u7406\u60f3\u3002\u867d\u7136\u5728\u5176\u4ed6\u5b9e\u4f53\u7624\u4e2d\u6709\u6548\u7684\u7597\u6cd5\uff08\u5982\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6297CTLA-4\u548c\u6297PD-1\uff09\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u65f6\u5bf9\u665a\u671f\u524d\u5217\u817a\u764c\u7684\u7597\u6548\u6709\u9650\uff0c\u4f46\u8fd9\u79cd\u6548\u679c\u7684\u7f3a\u4e4f\u53ef\u80fd\u4e0e\u524d\u5217\u817a\u80bf\u7624\u4e2d\u68c0\u67e5\u70b9\u914d\u4f53\u7684\u4f4e\u8868\u8fbe\u6709\u5173\u3002\u6b64\u5916\uff0c\u80bf\u7624\u7684\u5185\u5728\u7279\u5f81\uff08\u5982\u4f4e\u7a81\u53d8\u8d1f\u8377\uff09\u4e5f\u53ef\u80fd\u662f\u5f71\u54cd\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n

\u5c3d\u7ba1\u5982\u6b64\uff0c\u524d\u5217\u817a\u764c\u5177\u6709\u8868\u8fbe\u9650\u4e8e\u5668\u5b98\u672c\u8eab\u7684\u51e0\u79cd\u5173\u952e\u80bf\u7624\u6297\u539f\uff08\u5982PSMA\u548cPSA\uff09\uff0c\u8fd9\u4f7f\u5f97\u524d\u5217\u817a\u764c\u6210\u4e3a\u75ab\u82d7\u6cbb\u7597\u7684\u7406\u60f3\u9776\u70b9\u3002\u75ab\u82d7\u6709\u53ef\u80fd\u5c06\u201c\u51b7\u201d\u80bf\u7624\u8f6c\u53d8\u4e3a\u201c\u70ed\u201d\u80bf\u7624\uff0c\u4f7f\u5176\u66f4\u5bb9\u6613\u53d7\u5230\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u653b\u51fb\u3002<\/p>\n

mCRPC\u7684\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\u5bf9\u514d\u75ab\u6cbb\u7597\u63d0\u51fa\u4e86\u91cd\u5927\u6311\u6218\u3002\u53ef\u80fd\u9700\u8981\u8054\u5408\u6cbb\u7597\u7b56\u7565\uff0c\u4e0d\u4ec5\u8981\u89e3\u9664\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u6291\u5236\uff0c\u8fd8\u8981\u6539\u5584\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012\u3002\u5c24\u5176\u662f\u901a\u8fc7\u75ab\u82d7\u6765\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u589e\u5f3a\u708e\u75c7\u53cd\u5e94\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u589e\u5f3a\u9002\u5e94\u6027\u514d\u75ab\u7684\u6fc0\u6d3b\u548c\u529f\u80fd\u3002\u6b64\u5916\uff0c\u6297\u4f53\u53ef\u4ee5\u963b\u65ad\u7ef4\u6301\u6297\u708e\u80bf\u7624\u73af\u5883\u6240\u9700\u7684\u5173\u952e\u76f8\u4e92\u4f5c\u7528\uff0c\u4f8b\u5982\u6291\u5236MDSCs\u548cTAMs\u7684\u529f\u80fd\u548c\u751f\u5b58\u3002<\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u8054\u5408\u7597\u6cd5\u6709\u671b\u5e7f\u6cdb\u6fc0\u6d3b\u5e76\u52a8\u5458\u514d\u75ab\u7cfb\u7edf\u4ee5\u5bf9\u6297\u524d\u5217\u817a\u764c\u3002\u603b\u4f53\u800c\u8a00\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u53ef\u80fd\u9700\u8981\u8054\u5408\u6cbb\u7597\u65b9\u6848\u6765\u8bf1\u5bfc\u8db3\u591f\u7684\u514d\u75ab\u6d3b\u6027\uff0c\u4f7f\u5176\u5728\u524d\u5217\u817a\u764c\u7684\u6cbb\u7597\u4e2d\u4ea7\u751f\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u7ae0\u9707<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u6797\u5b50\u7545 \u90d1\u5bb6\u6021<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n

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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
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\u53ef\u4ee5\u67e5\u8be22024\u5e74\u6700\u65b0SCI\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\u5566\uff01<\/a>
\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c35\u7ae0 \u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\uff1a\u4e00\u4e2a\u4e0d\u65ad\u53d1\u5c55\u7684\u9886\u57df\uff08\u4e0a\uff09 35.3  \u80bf\u7624\u75ab\u82d7 \u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u901a\u8fc7\u964d\u4f4e\u6291\u5236\u6027\u514d\u75ab\u4fe1\u53f7\u6765\u589e\u5f3a\u73b0\u6709\u7684\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u800c\u75ab\u82d7\u7684…<\/p>\n","protected":false},"author":1,"featured_media":5693,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5697"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5697"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5697\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5693"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5697"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5697"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}