{"id":5707,"date":"2024-08-27T15:17:23","date_gmt":"2024-08-27T07:17:23","guid":{"rendered":"http:\/\/dh.oncolab.cn\/index.php\/2024\/08\/27\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac37%e7%ab%a0-%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%9a%84%e6%b2%bb%e7%96%97%e6%8c%91%e6%88%98%e4%b8%8e%e5%ba%94%e5%af%b9%e7%ad%96%e7%95%a5\/"},"modified":"2024-08-27T15:17:23","modified_gmt":"2024-08-27T07:17:23","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac37%e7%ab%a0-%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%9a%84%e6%b2%bb%e7%96%97%e6%8c%91%e6%88%98%e4%b8%8e%e5%ba%94%e5%af%b9%e7%ad%96%e7%95%a5","status":"publish","type":"post","link":"http:\/\/dh.oncolab.cn\/index.php\/2024\/08\/27\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac37%e7%ab%a0-%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%9a%84%e6%b2%bb%e7%96%97%e6%8c%91%e6%88%98%e4%b8%8e%e5%ba%94%e5%af%b9%e7%ad%96%e7%95%a5\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c37\u7ae0 \u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u6311\u6218\u4e0e\u5e94\u5bf9\u7b56\u7565\u2014\u2014\u4ece\u75ab\u82d7\u7814\u53d1\u5230\u5de8\u566c\u7ec6\u80de\u590d\u6781\u5316\uff08\u4e0a\uff09"},"content":{"rendered":"
\n
\n
\n
\n
\n

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c36\u7ae0 \u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u514d\u75ab\u6cbb\u7597\u9762\u4e34\u7684\u6311\u6218\uff08\u4e0b\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6574\u4e2a\u4eba\u4f53\u4f5c\u4e3a\u4e00\u4e2a\u6709\u673a\u4f53\uff0c\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u4e3a\u201c\u81ea\u6211\u201d\uff0c\u8fd9\u662f\u4e00\u4e2a\u5728\u529f\u80fd\u4e0a\u76f8\u4e92\u8054\u7cfb\u7684\u7ec6\u80de\u6574\u4f53\u3002\u201c\u81ea\u6211\u201d\u4e0e\u201c\u975e\u6211\u201d\u4e4b\u95f4\u7684\u5173\u952e\u533a\u522b\u4e3b\u8981\u7531\u514d\u75ab\u7cfb\u7edf\u6765\u8bc6\u522b\u3002\u8fd9\u79cd\u8bc6\u522b\u80fd\u529b\u5728\u4eba\u4f53\u4e0e\u5916\u754c\u7684\u63a5\u89e6\u754c\u9762\uff08\u5982\u76ae\u80a4\u3001\u80ba\u90e8\u548c\u80a0\u9053\uff09\u4e2d\u5c24\u4e3a\u91cd\u8981\uff0c\u51b3\u5b9a\u4e86\u514d\u75ab\u7cfb\u7edf\u5982\u4f55\u5e94\u5bf9\u5176\u4ed6\u7ec6\u80de\u548c\u5916\u6765\u7269\u8d28\u3002\u514d\u75ab\u7cfb\u7edf\u6709\u4e24\u4e2a\u6838\u5fc3\u8c03\u8282\u7cfb\u7edf\uff1a\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u548c\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u4ece\u8fdb\u5316\u89d2\u5ea6\u6765\u770b\uff0c\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u662f\u591a\u7ec6\u80de\u751f\u7269\u6700\u65e9\u7528\u4e8e\u62b5\u5fa1\u5916\u754c\u5a01\u80c1\u7684\u9632\u5fa1\u673a\u5236\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u83b7\u5f97\u6027\uff08\u6216\u9002\u5e94\u6027\uff09\u514d\u75ab\u7cfb\u7edf\u5728\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u8f83\u665a\uff0c\u4f46\u63d0\u4f9b\u4e86\u66f4\u5927\u7684\u7075\u6d3b\u6027\uff0c\u5e76\u5177\u6709\u91cd\u8981\u7684\u514d\u75ab\u8bb0\u5fc6\u529f\u80fd\u3002\u8fd9\u4e24\u4e2a\u76f8\u4e92\u5173\u8054\u7684\u7cfb\u7edf\u5171\u540c\u6784\u6210\u4e86\u529f\u80fd\u5b8c\u6574\u7684\u514d\u75ab\u4f53\u7cfb\u3002\u4ee5\u4e0b\u6bb5\u843d\u5c06\u4ecb\u7ecd\u5f53\u524d\u5bf9\u5c40\u90e8\u514d\u75ab\u5fae\u73af\u5883\u7684\u7406\u89e3\uff0c\u4ee5\u53ca\u5fae\u73af\u5883\u4e0e\u75be\u75c5\u8fdb\u7a0b\u4e4b\u95f4\u7684\u5173\u7cfb\uff08\u8be6\u89c1Fig 37.1<\/span>\uff09\u3002\u968f\u540e\uff0c\u6211\u4eec\u5c06\u8ba8\u8bba\u4e34\u5e8a\u6570\u636e\u4ee5\u53ca\u7ed3\u76f4\u80a0\u764c\u514d\u75ab\u6cbb\u7597\u7684\u524d\u666f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.1 \u7ed3\u80a0\u548c\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u514d\u75ab\u7cfb\u7edf<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u514d\u75ab\u7cfb\u7edf\u9891\u7e41\u53d7\u653b\u51fb\u7684\u90e8\u4f4d\uff0c\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4e0e\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u5fae\u5999\u5e73\u8861\u81f3\u5173\u91cd\u8981\u3002\u7279\u522b\u662f\u5728\u80a0\u9053\u8fd9\u4e00\u98df\u7269\u6444\u53d6\u548c\u5438\u6536\u7684\u4e3b\u8981\u573a\u6240\uff0c\u7ec6\u83cc\u3001\u75c5\u6bd2\u3001\u5f02\u7269\u548c\u6709\u6bd2\u7269\u8d28\u4e0d\u65ad\u8fdb\u5165\u673a\u4f53\uff0c\u5bf9\u514d\u75ab\u7cfb\u7edf\u6784\u6210\u6301\u7eed\u6311\u6218\u3002\u8fd9\u5c31\u9700\u8981\u514d\u75ab\u7cfb\u7edf\u5728\u5404\u4e2a\u5c42\u9762\u4e0a\u8fdb\u884c\u7cbe\u5bc6\u7684\u8c03\u63a7\uff0c\u5c24\u5176\u662f\u5728\u514d\u75ab\u53cd\u5e94\u7684\u8c03\u8282\u4e0a\u3002\u80a0\u9053\u80bf\u7624\u7684\u53d1\u751f\u4f1a\u6253\u7834\u8fd9\u79cd\u5fae\u8c03\u5e73\u8861\uff0c\u4ece\u800c\u5bf9\u673a\u4f53\u4ea7\u751f\u4e25\u91cd\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u548c\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u90fd\u80fd\u591f\u5c06\u80bf\u7624\u7ec6\u80de\u8bc6\u522b\u4e3a\u201c\u975e\u6211\u201d\uff0c\u5e76\u8bd5\u56fe\u6467\u6bc1\u8fd9\u4e9b\u7ec6\u80de\u3002\u9664\u4e86\u9632\u5fa1\u75c5\u539f\u4f53\uff0c\u8fd9\u4e00\u529f\u80fd\u5bf9\u4fdd\u62a4\u673a\u4f53\u7684\u5b8c\u6574\u6027\u4e5f\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u53ca\u65f6\u8bc6\u522b\u548c\u6d88\u9664\u6076\u6027\u6216\u8f6c\u5316\u7ec6\u80de\u662f\u7ef4\u6301\u751f\u7269\u4f53\u5065\u5eb7\u7684\u5173\u952e\u3002\u7136\u800c\uff0c\u5728\u80bf\u7624\u53d1\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u514d\u75ab\u7cfb\u7edf\u7684\u8fd9\u4e00\u529f\u80fd\u53ef\u80fd\u53d7\u5230\u5e72\u6270\uff0c\u5bfc\u81f4\u5176\u65e0\u6cd5\u6709\u6548\u904f\u5236\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u80a0\u9053\u4e2d\uff0c\u533a\u5206\u201c\u975e\u6211\u201d\u548c\u201c\u81ea\u6211\u201d\u5c24\u5176\u590d\u6742\u3002\u80a0\u9053\u5185\u5b58\u5728\u5927\u91cf\u7ec6\u83cc\uff0c\u8fd9\u4e9b\u7ec6\u83cc\u7684\u5b58\u5728\u5bf9\u4e8e\u7ef4\u6301\u4eba\u4f53\u7684\u52a8\u6001\u5e73\u8861\u81f3\u5173\u91cd\u8981\u3002\u80a0\u9053\u514d\u75ab\u7cfb\u7edf\u7684\u529f\u80fd\u5728\u4e8e\u7ef4\u6301\u8fd9\u79cd\u5fae\u89c2\u751f\u6001\u7684\u5e73\u8861\uff0c\u907f\u514d\u65e0\u4f11\u6b62\u7684\u708e\u75c7\u6216\u611f\u67d3\u3002\u708e\u75c7\u662f\u80bf\u7624\u53d1\u751f\u7684\u5e38\u89c1\u8bf1\u56e0\u4e4b\u4e00\u3002\u6162\u6027\u708e\u75c7\u6027\u80a0\u75c5\u4f1a\u5bfc\u81f4\u5c40\u90e8\u5fae\u73af\u5883\u7684\u5e73\u8861\u88ab\u4e25\u91cd\u7834\u574f\uff0c\u8fd9\u901a\u5e38\u4f34\u968f\u7740\u7279\u5b9a\u6709\u76ca\u83cc\u7fa4\u7684\u4e27\u5931\u548c\u6709\u5bb3\u83cc\u7fa4\u7684\u5165\u4fb5\uff0c\u5bfc\u81f4\u5c40\u90e8\u514d\u75ab\u7cfb\u7edf\u7684\u529f\u80fd\u5931\u8c03\u3002\u4ee4\u4eba\u610f\u5916\u7684\u662f\uff0c\u8fd9\u79cd\u708e\u75c7\u5fae\u73af\u5883\u53ef\u4ee5\u901a\u8fc7\u7caa\u4fbf\u79fb\u690d\u5f97\u5230\u6539\u5584\u3002\u5728\u957f\u671f\u708e\u75c7\u7684\u80cc\u666f\u4e0b\uff0c\u80bf\u7624\u53d1\u75c5\u7387\u7684\u5347\u9ad8\u4e5f\u5c31\u4e0d\u8db3\u4e3a\u5947\u4e86\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7ef4\u6301\u8fd9\u79cd\u5fae\u5999\u5e73\u8861\u7684\u5177\u4f53\u673a\u5236\uff0c\u4ee5\u53ca\u4fc3\u8fdb\u80bf\u7624\u53d1\u751f\u7684\u590d\u6742\u8c03\u63a7\u7f51\u7edc\uff0c\u6d89\u53ca\u5230\u514d\u75ab\u7ec6\u80de\u548c\u4fe1\u53f7\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u8fd9\u4e9b\u590d\u6742\u7f51\u7edc\u8fd8\u5305\u62ec\u996e\u98df\u3001\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\u4ee5\u53ca\u7c98\u819c\u5185\u7684\u8c03\u8282\u7ec6\u80de\u56e0\u5b50\u7f51\u7edc\u3002\u5927\u91cf\u7684\u6d41\u884c\u75c5\u5b66\u548c\u79d1\u5b66\u7814\u7a76\u8868\u660e\uff0c\u98df\u7528\u52a0\u5de5\u548c\u672a\u52a0\u5de5\u7684\u8089\u7c7b\u4f1a\u589e\u52a0\u7ed3\u76f4\u80a0\u764c\u7684\u98ce\u9669\uff0c\u800c\u5bcc\u542b\u7ea4\u7ef4\u7684\u996e\u98df\u5219\u6709\u52a9\u4e8e\u964d\u4f4e\u8fd9\u4e00\u98ce\u9669\u3002\u6b64\u5916\uff0c\u98df\u7269\u6210\u5206\u901a\u8fc7\u8c03\u8282\u7ed3\u80a0\u5fae\u751f\u7269\u7684\u4ee3\u8c22\uff0c\u5f71\u54cd\u7ed3\u80a0\u5065\u5eb7\u548c\u764c\u75c7\u98ce\u9669\u3002\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u80fd\u591f\u53d1\u9175\u590d\u6742\u7684\u98df\u7269\u6b8b\u7559\u7269\uff0c\u8fd9\u4e9b\u6b8b\u7559\u7269\u65e0\u6cd5\u88ab\u80a0\u9053\u9176\u6d88\u5316\u3002\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u77ed\u94fe\u8102\u80aa\u9178\uff08\u5982\u4e01\u9178\uff09\u7684\u91ca\u653e\u6709\u52a9\u4e8e\u6ee1\u8db3\u7ed3\u80a0\u53ca\u5168\u8eab\u7684\u65b0\u9648\u4ee3\u8c22\u9700\u6c42\u3002\u5177\u4f53\u800c\u8a00\uff0c\u4e01\u9178\u76d0\u5177\u6709\u663e\u8457\u7684\u4fc3\u7ed3\u80a0\u5065\u5eb7\u548c\u6297\u80bf\u7624\u7279\u6027\uff0c\u80fd\u591f\u901a\u8fc7\u7ef4\u6301\u7c98\u819c\u5b8c\u6574\u6027\u548c\u8c03\u8282\u514d\u75ab\u3001\u57fa\u56e0\u8868\u8fbe\u53ca\u8868\u89c2\u9057\u4f20\u6765\u6291\u5236\u708e\u75c7\u548c\u764c\u75c7\u7684\u53d1\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u901a\u8fc7\u65b0\u7684\u7efc\u5408\u5206\u6790\uff0c\u6211\u4eec\u9010\u6e10\u7406\u89e3\u4e86\u590d\u6742\u7684\u8fde\u9501\u7f51\u7edc\u3002\u4f8b\u5982\uff0c\u6211\u4eec\u5f00\u59cb\u660e\u767d\uff0c\u4e3a\u4ec0\u4e48\u589e\u52a0\u94c1\u7684\u6444\u5165\u4f1a\u5bfc\u81f4\u80bf\u7624\u7684\u53d1\u751f\u3002\u7136\u800c\uff0c\u9664\u4e86\u5bf9\u6076\u6027\u8f6c\u5316\u548c\u80bf\u7624\u542f\u52a8\u7684\u5f71\u54cd\u4e4b\u5916\uff0c\u514d\u75ab\u7cfb\u7edf\u5728\u80bf\u7624\u8fdb\u5c55\u548c\u8f6c\u79fb\u8fc7\u7a0b\u4e2d\u6240\u8d77\u7684\u4f5c\u7528\u8fd8\u6709\u5f85\u6df1\u5165\u63a2\u7d22\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 37.1 \u6982\u89c8<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.2 \u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\uff1a\u5f71\u54cd\u9884\u540e\u548c\u6cbb\u7597\u7684\u5173\u952e\u56e0\u7d20<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4ece\u514d\u75ab\u5b66\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u80bf\u7624\u7ec6\u80de\u5bf9\u5468\u56f4\u7ec4\u7ec7\u3001\u6dcb\u5df4\u7ed3\u548c\u5176\u4ed6\u5668\u5b98\u7684\u4fb5\u88ad\u5c24\u4e3a\u91cd\u8981\u3002\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\u4e0e\u9a7b\u7559\u5728\u76f8\u5e94\u7ec4\u7ec7\u4e2d\u7684\u7279\u5b9a\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u4ecd\u5b58\u5728\u8bb8\u591a\u672a\u89e3\u4e4b\u8c1c\u3002\u786e\u5207\u7684\u76f8\u4e92\u4f5c\u7528\u673a\u5236\u53ca\u5176\u6240\u6d89\u53ca\u7684\u4fe1\u53f7\u4f20\u5bfc\u8def\u5f84\u4ecd\u7136\u77e5\u4e4b\u751a\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5f53\u80bf\u7624\u7ec6\u80de\u7a7f\u8d8a\u4e0d\u540c\u7684\u514d\u75ab\u5fae\u73af\u5883\u65f6\uff0c\u5b83\u4eec\u80fd\u591f\u4fb5\u5165\u786c\u819c\u5916\u8102\u80aa\u3001\u7a7f\u8fc7\u6dcb\u5df4\u7ba1\u3001\u8fdb\u5165\u5916\u5468\u8840\u6db2\uff0c\u5e76\u6700\u7ec8\u6269\u6563\u5230\u809d\u810f\u3001\u80ba\u7b49\u5668\u5b98\u3002\u4e00\u4e2a\u5173\u952e\u7684\u514d\u75ab\u5b66\u95ee\u9898\u662f\uff1a\u81ea\u539f\u53d1\u80bf\u7624\u5f62\u6210\u4e4b\u521d\uff08\u89c1Fig 37.2<\/span>\uff09\uff0c\u54ea\u4e9b\u514d\u75ab\u7ec6\u80de\u4e0e\u7ed3\u76f4\u80a0\u764c\u5bc6\u5207\u76f8\u5173\uff1f\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u6dcb\u5df4\u7ec6\u80de\u662f\u6700\u663e\u8457\u7684\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u4e4b\u4e00\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5173\u4e8e\u7ed3\u76f4\u80a0\u764c\u514d\u75ab\u8fc7\u7a0b\u7684\u65e9\u671f\u7814\u7a76\u4e4b\u4e00\u662f\u75c5\u7406\u5b66\u5bb6\u89c2\u5bdf\u5230\u7ed3\u76f4\u80a0\u764c\u539f\u53d1\u80bf\u7624\u9644\u8fd1\u5b58\u5728\u6dcb\u5df4\u7ed3\u6784\u3002\u8fd9\u4e00\u53d1\u73b0\u662f\u57fa\u4e8e\u5df2\u77e5\u7684\u80a0\u9053\u5185\u5b58\u5728Peyer\u6591\u5757\uff08\u4ee5\u53ca\u5176\u4ed6\u6dcb\u5df4\u6837\u7ed3\u6784\uff09\u800c\u5f97\u51fa\u7684\u3002\u968f\u7740\u7279\u5f02\u6027\u67d3\u8272\u6280\u672f\u7684\u53d1\u5c55\uff0c\u75c5\u7406\u5b66\u5bb6\u548c\u514d\u75ab\u5b66\u5bb6\u5f97\u4ee5\u66f4\u597d\u5730\u8868\u5f81\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\uff0c\u5e76\u7cfb\u7edf\u5730\u7814\u7a76\u7ed3\u76f4\u80a0\u764c\u53ca\u5176\u5468\u56f4\u7684\u514d\u75ab\u7ec6\u80de\u3002\u7814\u7a76\u4e0d\u4ec5\u8bc1\u5b9e\u4e86\u6548\u5e94T\u7ec6\u80de\u7684\u5b58\u5728\uff0c\u8fd8\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u5c40\u90e8\u5fae\u73af\u5883\u7684\u7ec4\u6210\u4e0e\u539f\u53d1\u80bf\u7624\u5404\u4e2a\u9636\u6bb5\u7684\u4e34\u5e8a\u75c5\u7a0b\u4e4b\u95f4\u7684\u5bc6\u5207\u8054\u7cfb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7279\u522b\u662f\u5728III\u671f\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u7814\u7a76\u8868\u660eT\u7ec6\u80de\u5bc6\u5ea6\u4e0e\u63d0\u9ad8\u603b\u4f53\u751f\u5b58\u7387\u5bc6\u5207\u76f8\u5173\u3002\u5bf9\u539f\u53d1\u6027\u7ed3\u76f4\u80a0\u80bf\u7624\u7684\u5206\u6790\u8fdb\u4e00\u6b65\u663e\u793a\u4e86\u6548\u5e94T\u7ec6\u80de\u6570\u91cf\u7684\u9884\u540e\u4f5c\u7528\uff0c\u5c24\u5176\u662fCD3\u548cCD8\u8868\u9762\u6807\u5fd7\u3002\u8fd9\u4e9b\u6807\u5fd7\u7269\u4ee5\u53ca\u9897\u7c92\u9176B\u7684\u9884\u540e\u610f\u4e49\u5df2\u88ab\u72ec\u7acb\u7684\u7814\u7a76\u5c0f\u7ec4\u53cd\u590d\u9a8c\u8bc1\uff0c\u8fd9\u4e00\u73b0\u8c61\u5728\u5176\u4ed6\u764c\u75c7\u7c7b\u578b\u4e2d\u4e5f\u5f97\u5230\u4e86\u76f8\u4f3c\u7684\u8bc1\u5b9e\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 37.2 <\/span>\u5c40\u90e8\u5fae\u73af\u5883\u7684\u514d\u75ab\u5b66\u80cc\u666f\uff08\u4ece\u60a3\u8005\u5230\u5fae\u73af\u5883\uff0c\u518d\u56de\u5230\u60a3\u8005\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.3 \u91cf\u5316\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\uff1a\u7ec4\u7ec7\u4e2d\u514d\u75ab\u7ec6\u80de\u7684\u6d4b\u91cf<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u968f\u7740\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u4ece\u8bc4\u4f30HE\u5207\u7247\u4e2d\u7684\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u5230\u81ea\u52a8\u5b9a\u91cf\u7279\u5b9a\u67d3\u8272\u7684\u6dcb\u5df4\u7ec6\u80de\u4e9a\u7fa4\uff0c\u5982\u4f55\u9009\u62e9\u6700\u4f73\u6807\u8bb0\u7269\u6210\u4e3a\u4e86\u4e00\u4e2a\u5173\u952e\u95ee\u9898\u3002\u672c\u8282\u5c06\u8ba8\u8bba\u514d\u75ab\u7ec6\u80de\u91cf\u5316\u7684\u4e00\u822c\u65b9\u6cd5\uff0c\u5e76\u901a\u8fc7\u4e24\u4e2a\u4f8b\u5b50\u5c55\u793a\u8fd9\u4e00\u9886\u57df\u4e2d\u7684\u590d\u6742\u6027\u548c\u4e0d\u786e\u5b9a\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6548\u5e94T\u7ec6\u80de\u7684\u7ecf\u5178\u8868\u9762\u6807\u5fd7\u5305\u62ecCD3\u3001CD4\u548cCD8\uff0c\u5176\u4e2dCD3\u662f\u6cdbT\u7ec6\u80de\u6807\u5fd7\uff0cCD4\u662f\u8f85\u52a9\u6027T\u7ec6\u80de\u6807\u5fd7\u3002\u7136\u800c\uff0c\u53e6\u4e00\u79cdT\u7ec6\u80de\u6807\u8bb0\u7269FOXP3\u5f15\u53d1\u4e86\u76f8\u4e92\u77db\u76fe\u7684\u7ed3\u679c\u3002FOXP3\u662f\u4e3b\u8981\u5728\u8c03\u8282\u6027T\u7ec6\u80de\u4e2d\u8868\u8fbe\u7684\u6838\u8f6c\u5f55\u56e0\u5b50\uff0c\u800c\u8c03\u8282\u6027T\u7ec6\u80de\u662f\u5177\u6709\u6291\u5236\u529f\u80fd\u7684T\u7ec6\u80de\u4e9a\u7fa4\u3002\u6700\u521d\uff0c\u4eba\u4eec\u8ba4\u4e3a\u8fd9\u4e9b\u7ec6\u80de\u7684\u5b58\u5728\u610f\u5473\u7740\u514d\u75ab\u53cd\u5e94\u53d7\u963b\uff0c\u662f\u4e0d\u5229\u7684\u5fae\u73af\u5883\u3002\u7136\u800c\uff0c\u5bf9\u7ed3\u76f4\u80a0\u764c\u7684\u7cfb\u7edf\u5206\u6790\u663e\u793a\u51fa\u4e0d\u540c\u7684\u7ed3\u8bba\uff1a\u4e0d\u4ec5CD3\u3001CD8\u3001\u9897\u7c92\u9176B\u548cCD45RO\u9633\u6027\u7ec6\u80de\u663e\u793a\u51fa\u826f\u597d\u7684\u9884\u540e\u76f8\u5173\u6027\uff0cFOXP3\u9633\u6027\u6dcb\u5df4\u7ec6\u80de\u4e5f\u6709\u7c7b\u4f3c\u7684\u6548\u679c\u3002\u8fd9\u8868\u660e\uff0cFOXP3\u9633\u6027\u6dcb\u5df4\u7ec6\u80de\u5bc6\u5ea6\u8d8a\u9ad8\uff0c\u9884\u540e\u53ef\u80fd\u8d8a\u597d\u3002\u8fd9\u4e00\u73b0\u8c61\u7684\u89e3\u91ca\u6709\u4e24\u4e2a\u65b9\u9762\uff0c\u4e14\u5747\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u9996\u5148\uff0c\u514d\u75ab\u53cd\u5e94\u9700\u8981\u4e00\u5b9a\u7a0b\u5ea6\u7684\u805a\u96c6\uff0c\u800c\u8fd9\u79cd\u805a\u96c6\u7531\u8c03\u8282\u6027T\u7ec6\u80de\u9a71\u52a8\u3002\u56e0\u6b64\uff0c\u5931\u53bb\u8c03\u8282\u548c\u805a\u96c6\u80fd\u529b\u7684\u514d\u75ab\u7ec6\u80de\u53ef\u80fd\u65e0\u6cd5\u5f62\u6210\u6709\u6548\u7684\u514d\u75ab\u53cd\u5e94\u3002\u5176\u6b21\uff0c\u5bf9FOXP3\u9633\u6027\u6dcb\u5df4\u7ec6\u80de\u7fa4\u4f53\u7684\u8fdb\u4e00\u6b65\u5206\u6790\u63ed\u793a\u4e86\u5b83\u4eec\u7684\u529f\u80fd\u591a\u6837\u6027\u3002\u56e0\u6b64\uff0c\u4ec5\u7528FOXP3\u6765\u8bc6\u522b\u529f\u80fd\u6291\u5236\u6027\u3001\u5bf9\u60a3\u8005\u6709\u5bb3\u7684\u6dcb\u5df4\u7ec6\u80de\u4e9a\u7fa4\u53ef\u80fd\u4e0d\u591f\u7279\u5f02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9664\u4e86\u627e\u5230\u7406\u60f3\u7684\u5b9a\u91cf\u6807\u8bb0\u7269\u5916\uff0c\u514d\u75ab\u7ec6\u80de\u7684\u7a7a\u95f4\u5206\u5e03\u4e5f\u662f\u53e6\u4e00\u4e2a\u91cd\u8981\u53c2\u6570\u3002\u514d\u75ab\u7ec6\u80de\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u5b9a\u4f4d\u5e76\u975e\u968f\u673a\uff0c\u800c\u5927\u591a\u6570\u6dcb\u5df4\u7ec6\u80de\u5b9a\u4f4d\u4e8e\u95f4\u8d28\u95f4\u9694\u5185\uff0c\u4ec5\u6709\u4e00\u5c0f\u90e8\u5206\u76f4\u63a5\u4e0e\u80bf\u7624\u4e0a\u76ae\u63a5\u89e6\u3002\u8fd9\u4e00\u53d1\u73b0\u7684\u4e00\u4e2a\u542b\u4e49\u662f\uff0c\u6297\u80bf\u7624\u4f5c\u7528\u53ef\u80fd\u662f\u7531T\u7ec6\u80de\u91ca\u653e\u7684\u7ec6\u80de\u56e0\u5b50\u6240\u4ecb\u5bfc\u3002\u7136\u800c\uff0c\u6700\u65b0\u6570\u636e\u663e\u793a\uff0c\u901a\u8fc7\u9ad8\u5206\u8fa8\u7387\u5206\u6790T\u7ec6\u80de\u7684\u5b9a\u4f4d\uff0c\u76f4\u63a5\u4e0e\u80bf\u7624\u7ec6\u80de\u63a5\u89e6\u7684T\u7ec6\u80de\u5bf9\u6709\u5229\u9884\u540e\u7684\u8d21\u732e\u6700\u5927\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u7ec4\u7ec7\u5fae\u73af\u5883\u4e2d\uff0c\u53e6\u4e00\u7c7b\u91cd\u8981\u7684\u6dcb\u5df4\u7ec6\u80de\u662f\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u3002\u8fd9\u4e9b\u5177\u6709\u826f\u597d\u80bf\u7624\u6740\u4f24\u80fd\u529b\u7684\u5148\u5929\u514d\u75ab\u7ec6\u80de\u88ab\u8ba4\u4e3a\u5728\u6291\u5236\u80bf\u7624\u8fdb\u5c55\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u4e0eT\u7ec6\u80de\u76f8\u6bd4\uff0cNK\u7ec6\u80de\u6709\u4e00\u4e2a\u663e\u8457\u7684\u4f18\u52bf\uff1a\u5b83\u4eec\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4e0d\u4f9d\u8d56\u4e8e\u6297\u539f\u3002\u5373\u4f7f\u9776\u7ec6\u80de\u8868\u9762\u7f3a\u4e4f\u914d\u4f53\uff0cNK\u7ec6\u80de\u4ecd\u80fd\u88ab\u6fc0\u6d3b\u3002\u5728\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u7684\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cNK\u7ec6\u80de\u5bf9\u7f3a\u5931HLA I\u7c7b\u5206\u5b50\u7684\u80bf\u7624\u7ec6\u80de\u8868\u73b0\u51fa\u5f3a\u5927\u7684\u7834\u574f\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u63a8\u6d4bNK\u7ec6\u80de\u53ef\u80fd\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u826f\u597d\u9884\u540e\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u7136\u800c\uff0c\u7cfb\u7edf\u5206\u6790\u7ed3\u76f4\u80a0\u764c\u6807\u672c\u540e\u53d1\u73b0\uff0c\u5c3d\u7ba1\u8d8b\u5316\u56e0\u5b50\u548c\u7c98\u9644\u5206\u5b50\u652f\u6301NK\u7ec6\u80de\u7684\u5b58\u6d3b\u548c\u6fc0\u6d3b\uff0c\u80bf\u7624\u4e2d\u7684NK\u7ec6\u80de\u6570\u91cf\u5728\u817a\u7624\u7684\u65e9\u671f\u9636\u6bb5\u5df2\u7ecf\u663e\u8457\u51cf\u5c11\u3002\u8fd9\u4e00\u73b0\u8c61\u5728\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\u53ca\u4e73\u817a\u764c\u4e2d\u4e5f\u5f97\u5230\u4e86\u7c7b\u4f3c\u7684\u89c2\u5bdf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u7c7b\u6dcb\u5df4\u7ec6\u80de\uff0cB\u7ec6\u80de\uff0c\u76ee\u524d\u5c1a\u672a\u88ab\u8ba4\u4e3a\u4e0e\u7ed3\u76f4\u80a0\u764c\u7684\u8fdb\u5c55\u6709\u663e\u8457\u5173\u8054\u3002\u7136\u800c\uff0c\u9488\u5bf9\u80bf\u7624\u76f8\u5173\u6297\u539f\u7684\u6297\u4f53\u53cd\u5e94\u5728\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5df2\u6709\u62a5\u9053\u3002B\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\u901a\u5e38\u5b58\u5728\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u7cfb\u7edf\u5206\u6790\u4e5f\u8868\u660e\u5b83\u4eec\u53ef\u80fd\u5177\u6709\u6709\u76ca\u4f5c\u7528\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7ec6\u80de\u662f\u5426\u4ee5\u53ca\u5982\u4f55\u5f71\u54cd\u80bf\u7624\u751f\u957f\u8fd8\u6709\u5f85\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.4 \u514d\u75ab\u7ec6\u80de\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u9884\u540e\u548c\u9884\u6d4b\u4ef7\u503c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u901a\u8fc7\u6bd4\u8f83\u4e0d\u540c\u9636\u6bb5\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u6dcb\u5df4\u7ec6\u80de\uff0c\u53d1\u73b0\u8f6c\u79fb\u671f\u4e0e\u5316\u7597\u53ca\u809d\u8f6c\u79fb\u7076\u7684\u5207\u9664\u5bc6\u5207\u76f8\u5173\u3002\u5bf9\u4e8e\u65e0\u6cd5\u624b\u672f\u5207\u9664\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u6765\u8bf4\uff0c\u9884\u540e\u8f83\u5dee\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a28\u4e2a\u6708\u3002\u540c\u6837\uff0c\u5bf9\u4e8e\u53ef\u5207\u9664\u7684\u8f6c\u79fb\u7624\uff0cT\u7ec6\u80de\u6570\u91cf\u6210\u4e3a\u672f\u540e\u4e34\u5e8a\u75c5\u7a0b\u7684\u91cd\u8981\u9884\u540e\u6307\u6807\u3002\u5bf9\u4e8e\u65e0\u6cd5\u624b\u672f\u7684\u80bf\u7624\u60a3\u8005\uff0c\u5316\u7597\u662f\u552f\u4e00\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\u7684\u5168\u73bb\u7247\u6210\u50cf\u5b9a\u91cf\u5206\u6790\u4e2d\uff0c\u6548\u5e94T\u7ec6\u80de\u5bc6\u5ea6\u4e0e\u5316\u7597\u53cd\u5e94\u4e4b\u95f4\u7684\u5173\u7cfb\u5f97\u5230\u4e86\u9a8c\u8bc1\uff0c\u7279\u522b\u662f\u5728\u6d78\u6da6\u6027\u8fb9\u7f18\u533a\u57df\u3002\u8fd9\u4e00\u53d1\u73b0\u968f\u540e\u4e5f\u88ab\u53e6\u4e00\u7814\u7a76\u5c0f\u7ec4\u72ec\u7acb\u8bc1\u5b9e\u3002\u4e00\u4e2a\u6709\u8da3\u7684\u73b0\u8c61\u662f\uff0c\u8fd9\u79cd\u5173\u7cfb\u4e0d\u4ec5\u9002\u7528\u4e8e\u4f0a\u7acb\u66ff\u5eb7\u6216\u8349\u9178\u94c2\u7c7b\u5316\u7597\uff0c\u4e5f\u4e0d\u53d7\u4f34\u968f\u6297\u4f53\u6cbb\u7597\u7684\u5f71\u54cd\u3002\u5c3d\u7ba1\u6d78\u6da6\u6027\u7ec6\u80de\u5bc6\u5ea6\u80fd\u591f\u9884\u6d4b\u5316\u7597\u53cd\u5e94\uff0c\u4f46\u4ece\u4e34\u5e8a\u89d2\u5ea6\u6765\u770b\uff0c\u7ec4\u7ec7\u5185\u7ec6\u80de\u6e17\u900f\u7684\u7a33\u5065\u6027\u662f\u5173\u952e\u56e0\u7d20\u3002\u901a\u8fc7\u5168\u81ea\u52a8\u514d\u75ab\u7ec6\u80de\u5b9a\u91cf\u5206\u6790\uff0c\u53bb\u9664\u4e86\u574f\u6b7b\u533a\u548c\u4f2a\u5f71\u540e\uff0c\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u6d78\u6da6\u6027\u7ec6\u80de\u5bc6\u5ea6\u7684\u5f02\u8d28\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u539f\u53d1\u80bf\u7624\u8868\u73b0\u51fa\u663e\u8457\u7684\u5f02\u8d28\u6027\uff0c\u8fd9\u79cd\u5f02\u8d28\u6027\u5728\u8f6c\u79fb\u6027\u75c5\u53d8\u4e2d\u4e5f\u5b58\u5728\u3002\u6709\u8da3\u7684\u662f\uff0c\u5c11\u6570\u590d\u53d1\u8f6c\u79fb\u7076\u7684\u7cfb\u7edf\u5206\u6790\u8868\u660e\uff0c\u5373\u4f7f\u5728\u957f\u671f\u7684\u540c\u6b65\u5316\u7597\u8fc7\u7a0b\u4e2d\uff0c\u6d78\u6da6\u6027\u7ec6\u80de\u7684\u5bc6\u5ea6\u4e5f\u53ef\u4ee5\u4fdd\u6301\u7a33\u5b9a\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5728\u5c04\u9891\u6d88\u878d\u53e6\u4e00\u4e2a\u809d\u8f6c\u79fb\u7624\u540e\uff0c\u590d\u53d1\u75c5\u53d8\u663e\u793a\u51fa\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u589e\u5f3a\uff0c\u8fd9\u8868\u660e\u901a\u8fc7\u6cbb\u7597\u53ef\u80fd\u5c06\u6d78\u6da6\u6027\u8f83\u5dee\u7684\u75c5\u53d8\u8f6c\u5316\u4e3a\u6d78\u6da6\u6027\u8f83\u9ad8\u7684\u75c5\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.5 \u539f\u53d1\u80bf\u7624\u4e0e\u8f6c\u79fb\uff1a\u4e24\u4e2a\u4e0d\u540c\u7684\u6982\u5ff5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e00\u4e2a\u91cd\u8981\u7684\u95ee\u9898\u662f\uff0c\u539f\u53d1\u80bf\u7624\u7684\u514d\u75ab\u7279\u5f81\u662f\u5426\u540c\u6837\u9002\u7528\u4e8e\u8f6c\u79fb\u7076\u3002\u5728\u5bf9\u7ed3\u76f4\u80a0\u764c\u8f6c\u79fb\u81f3\u4e0d\u540c\u90e8\u4f4d\uff08\u5982\u80ba\u548c\u809d\uff09\u8fdb\u884c\u7684\u7cfb\u7edf\u5206\u6790\u4e2d\uff0c\u76ee\u524d\u83b7\u5f97\u7684\u6570\u636e\u8f83\u4e3a\u6709\u9650\u3002\u7136\u800c\uff0c\u73b0\u6709\u6570\u636e\u6e05\u695a\u5730\u8868\u660e\uff0c\u5728\u591a\u4e2a\u5c42\u9762\u4e0a\uff0c\u4e0d\u540c\u5668\u5b98\u4e4b\u95f4\u5b58\u5728\u7279\u5f02\u6027\u5dee\u5f02\u3002<\/p>\n

\u7ed3\u76f4\u80a0\u764c\u548c\u80be\u7ec6\u80de\u764c\u7684\u7814\u7a76\u663e\u793a\uff0cCD8\u9633\u6027T\u7ec6\u80de\u548cDC-LAMP\u9633\u6027\u6297\u539f\u63d0\u5448\u7ec6\u80de\uff08\u4e3b\u8981\u6307\u6210\u719f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff09\u7684\u5bc6\u5ea6\u5728\u9884\u540e\u8bc4\u4f30\u4e2d\u5177\u6709\u91cd\u8981\u4ef7\u503c\uff0c\u8fd9\u4e00\u514d\u75ab\u6a21\u5f0f\u5728\u4ece\u80ba\u539f\u53d1\u7076\u5230\u8f6c\u79fb\u6027\u75c5\u53d8\u7684\u8fc7\u7a0b\u4e2d\u5747\u5f97\u5230\u9a8c\u8bc1\u3002\u7136\u800c\uff0c\u7ed3\u76f4\u80a0\u764c\u548c\u80be\u7ec6\u80de\u764c\u5728\u4e34\u5e8a\u5f71\u54cd\u4e0a\u5374\u5448\u73b0\u51fa\u5b8c\u5168\u76f8\u53cd\u7684\u7ed3\u679c\uff0c\u8fd9\u4e5f\u53cd\u6620\u4e86\u8fd9\u4e00\u9886\u57df\u7684\u590d\u6742\u6027\u3002<\/p>\n

\u90a3\u4e48\uff0c\u539f\u53d1\u7076\u548c\u8f6c\u79fb\u7076\u4e4b\u95f4\u7684\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u6a21\u5f0f\u662f\u5426\u4fdd\u6301\u4e00\u81f4\uff1f\u5728\u4e00\u7ec4\u539f\u53d1\u6027\u7ed3\u76f4\u80a0\u764c\u548c\u76f8\u5e94\u7684\u809d\u8f6c\u79fb\u7076\u6837\u672c\u4e2d\uff0c\u7814\u7a76\u53d1\u73b0\u539f\u53d1\u7076\u548c\u8f6c\u79fb\u7076\u4e2d\u9884\u540e\u826f\u597d\u6216\u4e0d\u4f73\u7684\u514d\u75ab\u5b66\u6807\u5fd7\u7684\u7b26\u5408\u7387\u4e3a70%\u3002\u76ee\u524d\uff0c\u9a71\u52a8\u539f\u53d1\u7076\u548c\u8f6c\u79fb\u7076\u514d\u75ab\u6d78\u6da6\u5f02\u8d28\u6027\u7684\u56e0\u7d20\u5c1a\u672a\u5f97\u5230\u5145\u5206\u9610\u660e\uff0c\u76f8\u5173\u7814\u7a76\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n

\u53e6\u4e00\u4e2a\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u662f\uff0c\u5982\u4f55\u89e3\u91ca\u4e00\u4e2a\u51e0\u4e4e\u6ca1\u6709\u514d\u75ab\u6d78\u6da6\u7684\u80bf\u7624\u75c5\u53d8\u5728\u60a3\u8005\u4f53\u5185\u5982\u4f55\u6f14\u53d8\u4e3a\u9ad8\u5ea6\u6d78\u6da6\u6027\u7684\u75c5\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.6 \u514d\u75ab\u7ec6\u80de\u4e0e\u6cbb\u7597\uff1a\u4ece\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u5230\u66f4\u5e7f\u6cdb\u7684\u5f71\u54cd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u66f4\u8fdb\u4e00\u6b65\u7684\u95ee\u9898\u662f\uff1a\u8fd9\u4e9bT\u7ec6\u80de\u5728\u539f\u53d1\u80bf\u7624\u548c\u809d\u8f6c\u79fb\u4e2d\u7684\u5177\u4f53\u4f5c\u7528\u673a\u5236\u662f\u4ec0\u4e48\uff0c\u5b83\u4eec\u5982\u4f55\u6539\u5584\u60a3\u8005\u7684\u4e34\u5e8a\u75c5\u7a0b\uff1f\u7279\u522b\u662f\u5728\u5316\u7597\u7684\u5f71\u54cd\u65b9\u9762\uff0c\u53ef\u4ee5\u6709\u591a\u79cd\u89e3\u91ca\u3002\u5316\u7597\u836f\u7269\u53ef\u80fd\u901a\u8fc7\u589e\u5f3a\u6297\u539f\u63d0\u5448\u548c\u6fc0\u6d3b\u6548\u5e94T\u7ec6\u80de\u6765\u63d0\u9ad8\u514d\u75ab\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u8fd9\u4e0d\u4ec5\u6539\u5584\u4e86\u6297\u80bf\u7624\u53cd\u5e94\uff0c\u8fd8\u53ef\u80fd\u51cf\u5c11\u80bf\u7624\u5185\u7684\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u67d0\u4e9b\u5316\u7597\u836f\u7269\u8fd8\u80fd\u591f\u8bf1\u5bfc\u6240\u8c13\u7684\u201c\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u201d\uff0c\u4f8b\u5982\u5965\u6c99\u5229\u94c2\u3002\u8fd9\u4e9b\u836f\u7269\u901a\u8fc7\u5f15\u53d1\u66f4\u5177\u6297\u539f\u6027\u7684\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\uff0c\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u7684\u53cd\u5e94\u3002\u8fd9\u4e00\u8fc7\u7a0b\u5305\u62ec\u5728\u6811\u7a81\u72b6\u7ec6\u80de\u7b49\u76f8\u5173\u514d\u75ab\u7ec6\u80de\u4e0a\u4ea7\u751f\u7279\u522b\u6709\u6548\u7684\u6297\u539f\u5448\u9012\u8868\u4f4d\uff0c\u4f7f\u5316\u7597\u5728\u6297\u80bf\u7624\u4e2d\u66f4\u4e3a\u6709\u6548\u3002<\/p>\n

\u5316\u7597\u7684\u5176\u4ed6\u4f5c\u7528\u673a\u5236\u76ee\u524d\u6b63\u5728\u8f6c\u5316\u7814\u7a76\u9886\u57df\u5f97\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002\u591a\u4e2a\u7814\u7a76\u5c0f\u7ec4\u5df2\u7ecf\u72ec\u7acb\u9a8c\u8bc1\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u5728\u5316\u7597\u548c\u514d\u75ab\u6cbb\u7597\u6210\u529f\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u663e\u793a\uff0c\u5316\u7597\u53ef\u4ee5\u8bf1\u5bfc\u7ec6\u83cc\u4ece\u80a0\u9053\u7a7f\u8fc7\u7c98\u819c\u8fdb\u5165\u6dcb\u5df4\u7ed3\uff0c\u4ece\u800c\u589e\u5f3a\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u8bc6\u522b\u548c\u523a\u6fc0\u3002\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u83cc\u7684\u79cd\u7c7b\u8d77\u7740\u51b3\u5b9a\u6027\u4f5c\u7528\uff1a\u67d0\u4e9b\u7ec6\u83cc\u7269\u79cd\u80fd\u591f\u663e\u8457\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\uff0c\u800c\u53e6\u4e00\u4e9b\u5219\u53ef\u80fd\u5bfc\u81f4\u514d\u75ab\u6291\u5236\u3002\u56e0\u6b64\uff0c\u80a0\u9053\u4e2d\u6d3b\u8dc3\u7684\u7ec6\u83cc\u79cd\u7fa4\u7684\u7ec4\u6210\u6216\u5b58\u5728\u5bf9\u6cbb\u7597\u6548\u679c\u5177\u6709\u91cd\u8981\u5f71\u54cd\u3002\u76ee\u524d\uff0c\u8fd9\u4e00\u7814\u7a76\u6b63\u9010\u6b65\u8f6c\u5316\u4e3a\u5e72\u9884\u6027\u8bd5\u9a8c\u3002<\/p>\n

\u201c\u80bf\u7624\u5fae\u751f\u7269\u5b66\u201d\u8fd9\u4e00\u6982\u5ff5\u6b63\u5728\u9010\u6b65\u5f62\u6210\uff0c\u6307\u7684\u662f\u901a\u8fc7\u8c03\u8282\u5fae\u751f\u7269\u7ec4\u6765\u589e\u5f3a\u548c\u4f18\u5316\u764c\u75c7\u6cbb\u7597\u7684\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.7 \u5fae\u73af\u5883\u4e2d\u7684\u9ad3\u7cfb\u514d\u75ab\u7ec6\u80de\uff1a\u53ef\u5851\u6027\u4e0e\u514d\u75ab\u6291\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u9ad3\u7cfb\u7ec6\u80de\u662f\u6570\u91cf\u6700\u591a\u7684\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\uff0c\u5c24\u5176\u662f\u5728\u8f6c\u79fb\u7076\u4e2d\u3002\u5de8\u566c\u7ec6\u80de\u4f5c\u4e3a\u4e00\u7c7b\u529f\u80fd\u591a\u6837\u4e14\u9ad8\u5ea6\u590d\u6742\u7684\u5148\u5929\u514d\u75ab\u7ec6\u80de\uff0c\u5c55\u73b0\u51fa\u6781\u5927\u7684\u53ef\u5851\u6027\u3002\u9664\u4e86\u7ec4\u7ec7\u5185\u7684\u9a7b\u7559\u5de8\u566c\u7ec6\u80de\u5916\uff0c\u62db\u52df\u6765\u7684\u5355\u6838\u7ec6\u80de\u4e5f\u4f1a\u5728\u7ec4\u7ec7\u5185\u5206\u5316\u4e3a\u5de8\u566c\u7ec6\u80de\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u4e3b\u8981\u6765\u6e90\u4e8e\u7ec4\u7ec7\u9a7b\u7559\u7684\u5de8\u566c\u7ec6\u80de\u8fd8\u662f\u7531\u62db\u52df\u6765\u7684\u5de8\u566c\u7ec6\u80de\u5206\u5316\u800c\u6210\u3002<\/p>\n

\u529f\u80fd\u4e0a\uff0c\u5de8\u566c\u7ec6\u80de\u8868\u73b0\u51fa\u541e\u566c\u3001\u514d\u75ab\u6291\u5236\uff08\u5982\u901a\u8fc7\u4ea7\u751f\u7cbe\u6c28\u9178\u9176\u548c\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176\uff09\u548c\u6297\u80bf\u7624\uff08\u5982\u6d3b\u6027\u6c27\u5f62\u6210\uff09\u7b49\u591a\u91cd\u80fd\u529b\u3002\u6700\u521d\uff0c\u5de8\u566c\u7ec6\u80de\u88ab\u7b80\u5355\u5730\u5206\u7c7b\u4e3a\u4fc3\u8fdb\u80bf\u7624\u7684M2\u578b\u548c\u6297\u80bf\u7624\u7684M1\u578b\u3002\u7136\u800c\uff0c\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0c\u8fd9\u4e00\u5206\u7c7b\u65b9\u5f0f\u5df2\u88ab\u4fee\u8ba2\u3002\u4eba\u7c7b\u9ad3\u7cfb\u7ec6\u80de\u7684\u8868\u578b\u590d\u6742\u6027\u4e0d\u4ec5\u4e0d\u540c\u4e8e\u52a8\u7269\u6a21\u578b\uff0c\u800c\u4e14\u8868\u73b0\u51fa\u9ad8\u5ea6\u7684\u591a\u6837\u6027\u3002\u9488\u5bf9\u5de8\u566c\u7ec6\u80de\u7684\u6d88\u878d\u6216\u8c03\u8282\u7684\u5e72\u9884\u7b56\u7565\u76ee\u524d\u5df2\u8f6c\u5316\u4e3a\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u53e6\u4e00\u4e2a\u91cd\u8981\u7684\u9ad3\u7cfb\u7ec6\u80de\u7fa4\u4f53\u662f\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u7ec6\u80de\uff08MDSCs\uff09\u3002MDSCs\u901a\u5e38\u88ab\u5b9a\u4e49\u4e3a\u6765\u81ea\u9aa8\u9ad3\u7684\u672a\u6210\u719f\u9ad3\u7cfb\u7ec6\u80de\uff0c\u5b83\u4eec\u5bf9\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u53ca\u5de8\u566c\u7ec6\u80de\u7b49\u5176\u4ed6\u9ad3\u7cfb\u7ec6\u80de\u7684\u8c03\u8282\u5177\u6709\u6291\u5236\u4f5c\u7528\u3002MDSCs\u7684\u53e6\u4e00\u4e2a\u91cd\u8981\u529f\u80fd\u662f\u901a\u8fc7\u8017\u5c3d\u5fae\u73af\u5883\u4e2d\u7684\u7cbe\u6c28\u9178\u6765\u6291\u5236T\u7ec6\u80de\u6d3b\u6027\u3002MDSCs\u901a\u8fc7\u4ea7\u751f\u7cbe\u6c28\u9178\u9176\u5c06\u7cbe\u6c28\u9178\u964d\u89e3\u4e3al-\u9e1f\u6c28\u9178\u548c\u5c3f\u7d20\uff0c\u4ece\u800c\u5bfc\u81f4T\u7ec6\u80de\u5931\u6d3b\u3002<\/p>\n

\u5728\u8fd9\u79cd\u590d\u6742\u529f\u80fd\u7684\u8fde\u7eed\u4f53\u4e2d\uff0c\u4e0d\u540c\u9ad3\u7cfb\u7ec6\u80de\u4e9a\u7c7b\u7684\u7cbe\u786e\u533a\u5206\u4ee5\u53ca\u5176\u77ac\u65f6\u529f\u80fd\u72b6\u6001\u7684\u89c2\u6d4b\u4ecd\u7136\u5177\u6709\u6311\u6218\u6027\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u63ed\u793a\u5176\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

37.8 \u68c0\u67e5\u70b9\u6291\u5236\u548c\u5176\u4ed6\u4fe1\u53f7\u7ea7\u8054<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7279\u5b9a\u4fe1\u53f7\u5206\u5b50\u7684\u5b58\u5728\u6216\u7f3a\u5931\u4e0e\u514d\u75ab\u7ec6\u80de\u7684\u529f\u80fd\u5bc6\u5207\u76f8\u5173\u3002\u4ee5\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u5206\u5b50\u5bb6\u65cf\u4e3a\u4f8b\uff0c\u8fd9\u4e2a\u5bb6\u65cf\u5305\u62ecPD-1\u548cPD-2\u53d7\u4f53\u4ee5\u53ca\u5176\u914d\u4f53PD-L1\uff08B7-H1\uff09\uff0c\u8fd9\u4e9b\u4fe1\u53f7\u5206\u5b50\u6784\u6210\u4e86\u4e00\u4e2a\u4e0d\u65ad\u6269\u5c55\u7684\u5bb6\u65cf\uff0c\u8c03\u63a7\u7740\u5fae\u73af\u5883\u4e2d\u6240\u6709\u7c7b\u578b\u7684\u514d\u75ab\u7ec6\u80de\u7684\u884c\u4e3a\u3002PD-1\u662f\u4e00\u79cd\u5206\u5b50\u91cf\u4e3a55 kDa\u7684\u86cb\u767d\uff0c\u5176\u80de\u5916\u7ed3\u6784\u57df\u4e0e\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f-4\uff08CTLA-4\uff09\u5177\u670923%\u7684\u540c\u6e90\u6027\uff0c\u540e\u8005\u662f\u6d3b\u5316T\u7ec6\u80de\u7684\u53e6\u4e00\u91cd\u8981\u6291\u5236\u53d7\u4f53\u3002PD-1\u5728\u80f8\u817a\u548c\u5916\u5468\u8840\u4e2d\u5bf9T\u7ec6\u80de\u7684\u9009\u62e9\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u590d\u6742\u7684\u4f5c\u7528\u3002\u521d\u59cbT\u7ec6\u80de\u548cB\u7ec6\u80de\u4e0a\u7684PD-1\u8868\u8fbe\u6c34\u5e73\u8f83\u4f4e\uff0c\u53ea\u6709\u5728\u7ec6\u80de\u88ab\u6fc0\u6d3b\u540e\uff0cPD-1\u7684\u8868\u8fbe\u624d\u663e\u8457\u589e\u52a0\u3002\u6765\u81ea\u5c0f\u9f20\u6a21\u578b\u7684\u6570\u636e\u663e\u793a\uff0cPD-1\u5728\u9632\u6b62\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u4e2d\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002PD-1\u4e0e\u5176\u914d\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u4f1a\u964d\u4f4e\u8f85\u52a9\u6027T\u7ec6\u80de\u7684\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u589e\u6b96\u3002\u8fd9\u5728\u75c5\u6bd2\u611f\u67d3\u4e2d\u662f\u4e00\u4e2a\u5173\u952e\u673a\u5236\uff0cPD-1\u7684\u4f5c\u7528\u5728\u6b64\u7c7b\u60c5\u5883\u4e2d\u5c24\u4e3a\u660e\u663e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u764c\u75c7\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e9b\u4fe1\u53f7\u5206\u5b50\u5728\u5c40\u90e8\u5fae\u73af\u5883\u4e2d\u7684\u590d\u6742\u6027\u4ecd\u672a\u5b8c\u5168\u88ab\u9610\u660e\u3002\u6700\u521d\u63cf\u8ff0PD-1\/PD-L1\u8f74\u4f5c\u4e3a\u5e72\u6270\u7d20\u5e94\u7b54\u7684\u8c03\u63a7\u673a\u5236\u540e\uff0cPD-L1\u5728\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u4e0a\u7684\u8868\u8fbe\u53ca\u5176\u8c03\u63a7\u7684\u590d\u6742\u6027\u81f3\u4eca\u4ecd\u672a\u5b8c\u5168\u4e86\u89e3\u3002\u5728\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\u4e2d\uff0c\u51e0\u4e4e\u6240\u6709\u7684\u6dcb\u5df4\u7ec6\u80de\u90fd\u662fPD-1\u9633\u6027\uff0c\u800c\u80bf\u7624\u7ec6\u80dePD-L1\u5448\u9634\u6027\uff0c\u4fb5\u88ad\u8fb9\u7f18\u7684\u7279\u5b9a\u9ad3\u7ec6\u80de\u5219\u8868\u73b0\u51faPD-L1\u9633\u6027\u3002\u5728\u4e34\u5e8a\u4e0a\uff0c\u6291\u5236PD-1\/PD-L1\u8f74\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u6548\u679c\u5e76\u672a\u5982\u9884\u671f\u822c\u663e\u8457\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7136\u800c\uff0c\u5176\u4ed6\u8c03\u8282\u5206\u5b50\u4e5f\u5728\u8c03\u63a7\u514d\u75ab\u53cd\u5e94\u4e2d\u53d1\u6325\u4f5c\u7528\uff08\u6709\u65f6\u7279\u5f02\u6027\u5b58\u5728\u4e8e\u6d78\u6da6\u8fb9\u7f18\uff09\uff0c\u5305\u62ec\u542bv\u57df\u7684\u514d\u75ab\u7403\u86cb\u767d(Ig) T\u7ec6\u80de\u6d3b\u5316\u6291\u5236\u56e0\u5b50(VISTA)\u3001\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f-4 (CTLA-4)\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u8d85\u5bb6\u65cf\u6210\u54584 (TNFRSF4\uff0c\u4e5f\u79f0\u4e3aCD134\u548cOX40)\u3001T\u7ec6\u80de\u514d\u75ab\u7403\u86cb\u767d\u548c\u7c98\u86cb\u767d\u7ed3\u6784\u57df3 (TIM3)\u3001\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316\u57fa\u56e03\u86cb\u767d(LAG3)\u7b49\u3002\u5c3d\u7ba1\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u514d\u75ab\u8c03\u8282\u673a\u5236\u5df2\u88ab\u5e7f\u6cdb\u7814\u7a76\uff0c\u5e76\u9002\u7528\u4e8e\u5927\u591a\u6570\u53d7\u4f53-\u914d\u4f53\u5bf9\uff0c\u4f46\u5728\u5c40\u90e8\u5fae\u73af\u5883\u4e2d\u662f\u5426\u5b58\u5728\u5176\u4ed6\u672a\u53d1\u73b0\u7684\u53d7\u4f53\u6216\u914d\u4f53\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u56e0\u7d20\u5982\u4f55\u534f\u540c\u5f71\u54cd\u514d\u75ab\u53cd\u5e94\uff0c\u7279\u522b\u662f\u5728\u4eba\u4f53\u60a3\u8005\u4e2d\u7684\u8868\u73b0\uff0c\u4ecd\u5b58\u5728\u8bb8\u591a\u672a\u77e5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u76ee\u524d\u6700\u7a81\u51fa\u7684\u7814\u7a76\u95ee\u9898\u662f\u5982\u4f55\u901a\u8fc7\u8054\u5408\u6cbb\u7597\u6765\u6539\u5584\u4e34\u5e8a\u53cd\u5e94\uff0c\u4ee5\u53ca\u54ea\u79cd\u8054\u5408\u7597\u6cd5\u5728\u5b9e\u9645\u4e34\u5e8a\u73af\u5883\u4e2d\u6700\u6709\u53ef\u80fd\u53d6\u5f97\u6210\u529f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u66fe\u4e16\u7eaa<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u59da\u4f69\u8a00 \u675c\u8f7b\u677e<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u53ef\u4ee5\u67e5\u8be22024\u5e74\u6700\u65b0SCI\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\u5566\uff01<\/span><\/a>
\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

\u795e\u7ecf\u79d1\u5b66\u539f\u7406\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

\u5e38\u7528\u5b9e\u9a8c<\/span>\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:OncoLab<\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c36\u7ae0 \u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u514d\u75ab\u6cbb\u7597\u9762\u4e34\u7684\u6311\u6218\uff08\u4e0b\uff09 \u6574\u4e2a\u4eba\u4f53\u4f5c\u4e3a\u4e00\u4e2a\u6709\u673a\u4f53\uff0c\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u4e3a\u201c\u81ea\u6211\u201d\uff0c\u8fd9\u662f\u4e00\u4e2a\u5728\u529f\u80fd\u4e0a\u76f8\u4e92\u8054\u7cfb\u7684\u7ec6\u80de\u6574\u4f53\u3002\u201c\u81ea\u6211\u201d\u4e0e\u201c\u975e\u6211\u201d\u4e4b\u95f4…<\/p>\n","protected":false},"author":1,"featured_media":5704,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[59],"tags":[],"_links":{"self":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5707"}],"collection":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=5707"}],"version-history":[{"count":0,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/5707\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/5704"}],"wp:attachment":[{"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=5707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=5707"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/dh.oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=5707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}